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Thomas Kepler

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Physiology

Anatomy

B-Lymphocytes

Chemicals & Drugs

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HIV-1
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Guang Yang; S Munir Alam; Derek W Cain; Barton F Haynes; T Matt Holl; Thomas B Kepler; Yi Li; Hua-Xin Liao; Yang Liu; Xiaozhi Lu; Nathan I Nicely; Leonard Spicer; John L VandeBerg; Garnett Kelsoe
Identification of autoantigens recognized by the 2F5 and 4E10 broadly neutralizing HIV-1 antibodies.
Aaron G Schmidt; Ethan C Settembre; David E Shaw; Pirada Suphaphiphat; Huafeng Xu; Ruijun Zhang; Andrea Carfi; Philip R Dormitzer; Hana Golding; Barton F Haynes; Thomas B Kepler; Amir R Khan; Surender Khurana; Lisa R King; Hua-Xin Liao; Jody Manischewitz; M Anthony Moody; Timothy O'Donnell; Stephen C Harrison
Preconfiguration of the antigen-binding site during affinity maturation of a broadly neutralizing influenza virus antibody.
Cliburn Chan; Eric Monson; Samuel A Ramirez; Harald Schmidl; Matthew Billard; Thomas B Kepler
A model for migratory B cell oscillations from receptor down-regulation induced by external chemokine fields.

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2013: Guang Yang; S Munir Alam; Derek W Cain; Barton F Haynes; T Matt Holl; Thomas B Kepler; Yi Li; Hua-Xin Liao; Yang Liu; Xiaozhi Lu; Nathan I Nicely; Leonard Spicer; John L VandeBerg; Garnett Kelsoe
Identification of autoantigens recognized by the 2F5 and 4E10 broadly neutralizing HIV-1 antibodies.
The Journal of experimental medicine 2013;210(2):241-56.
2013: Aaron G Schmidt; Ethan C Settembre; David E Shaw; Pirada Suphaphiphat; Huafeng Xu; Ruijun Zhang; Andrea Carfi; Philip R Dormitzer; Hana Golding; Barton F Haynes; Thomas B Kepler; Amir R Khan; Surender Khurana; Lisa R King; Hua-Xin Liao; Jody Manischewitz; M Anthony Moody; Timothy O'Donnell; Stephen C Harrison
Preconfiguration of the antigen-binding site during affinity maturation of a broadly neutralizing influenza virus antibody.
Proceedings of the National Academy of Sciences of the United States of America 2013;110(1):264-9.
2013: Cliburn Chan; Eric Monson; Samuel A Ramirez; Harald Schmidl; Matthew Billard; Thomas B Kepler
A model for migratory B cell oscillations from receptor down-regulation induced by external chemokine fields.
Bulletin of mathematical biology 2013;75(1):185-205.
2012: Barton F Haynes; Garnett Kelsoe; Stephen C Harrison; Thomas B Kepler
B-cell-lineage immunogen design in vaccine development with HIV-1 as a case study.
Nature biotechnology 2012;30(5):423-33.
2012: Mattia Bonsignori; Xi Chen; John A Crump; Kwan-Ki Hwang; Saidi H Kapiga; Thomas B Kepler; Daniel M Kozink; Peter D Kwong; Hua-Xin Liao; John R Mascola; David C Montefiori; Robert J Parks; Noel E Sam; Georgia D Tomaras; Chun-Yen Tsao; Xueling Wu; Barton F Haynes
Two distinct broadly neutralizing antibody specificities of different clonal lineages in a single HIV-1-infected donor: implications for vaccine design.
Journal of virology 2012;86(8):4688-92.
2011: S Munir Alam; Kara Anasti; Bing Chen; S Moses Dennison; Michele Donathan; Andrew Foulger; Frederick Jaeger; Garnett Kelsoe; Thomas B Kepler; Hua-Xin Liao; Judith Lucas; Nathan Nicely; Robert Parks; Georgia D Tomaras; Laurent Verkoczy; Barton F Haynes
Differential reactivity of germ line allelic variants of a broadly neutralizing HIV-1 antibody to a gp41 fusion intermediate conformation.
Journal of virology 2011;85(22):11725-31.
2011: Hua-Xin Liao; Xiaozhi Lu; David M Margolis; Martin Markowitz; Eleanor Marshal; Dawn J Marshall; David C Montefiori; M Anthony Moody; Supriya Munshaw; George C Shaw; Birgitte B Simen; Georgia D Tomaras; Nathan Vandergrift; Gerald Voss; John F Whitesides; Jae-Sung Yu; Ruijun Zhang; S Munir Alam; Katharine J Bar; Scott D Boyd; Xi Chen; Thomas N Denny; Michael Egholm; Andrew Z Fire; Feng Gao; Paul A Goepfert; Bozena Hanczaruk; Sonya L Heath; Kwan-Ki Hwang; Garnett Kelsoe; Thomas B Kepler; Barton F Haynes
Initial antibodies binding to HIV-1 gp41 in acutely infected subjects are polyreactive and highly mutated.
The Journal of experimental medicine 2011;208(11):2237-49.
2011: Mattia Bonsignori; Xi Chen; John A Crump; Elin Gray; S Munir Alam; Kwan-Ki Hwang; Saidi H Kapiga; Garnett Kelsoe; Thomas B Kepler; Peter D Kwong; Hua-Xin Liao; Dawn J Marshall; John R Mascola; David C Montefiori; M Anthony Moody; Lynn Morris; Gary Nabel; Sijy O'Dell; Marie Pancera; Sanjay Phogat; Noel E Sam; Michael S Seaman; George M Shaw; Faruk Sinangil; Joseph Sodroski; Georgia D Tomaras; Chun-Yen Tsao; John F Whitesides; Lan Wu; Xinzhen Yang; Yang Yongping; Baoshan Zhang; Jiang Zhu; Barton F Haynes
Analysis of a clonal lineage of HIV-1 envelope V2/V3 conformational epitope-specific broadly neutralizing antibodies and their inferred unmutated common ancestors.
Journal of virology 2011;85(19):9998-10009.
2011: Ben-Jiang Ma; Sampa Santra; Richard M Scearce; Laura L Sutherland; Georgia D Tomaras; S Munir Alam; Cindy Bowman; Heather Desaire; Eden P Go; Thomas B Kepler; Norman L Letvin; Hua-Xin Liao; Xiaozhi Lu; Barton F Haynes
Envelope deglycosylation enhances antigenicity of HIV-1 gp41 epitopes for both broad neutralizing antibodies and their unmutated ancestor antibodies.
PLoS pathogens 2011;7(9):e1002200.
2011: James R R Whittle; Ruijun Zhang; Philip R Dormitzer; Hana Golding; Barton F Haynes; Thomas B Kepler; Surender Khurana; Lisa R King; Hua-Xin Liao; Jody Manischewitz; M Anthony Moody; Emmanuel B Walter; Stephen C Harrison
Broadly neutralizing human antibody that recognizes the receptor-binding pocket of influenza virus hemagglutinin.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(34):14216-21.
2011: Stanca M Ciupe; Patrick De Leenheer; Thomas B Kepler
Paradoxical suppression of poly-specific broadly neutralizing antibodies in the presence of strain-specific neutralizing antibodies following HIV infection.
Journal of theoretical biology 2011;277(1):55-66.
2011: Feng Feng; Ana Paula Sales; Thomas B Kepler
A Bayesian approach for estimating calibration curves and unknown concentrations in immunoassays.
Bioinformatics (Oxford, England) 2011;27(5):707-12.
2011: M Anthony Moody; Supriya Munshaw; Robert Parks; Elizabeth A Ramsburg; Georgia D Tomaras; Nathan A Vandergrift; Emmanuel B Walter; John F Whitesides; Christopher W Woods; Jae-Sung Yu; Ruijun Zhang; S Munir Alam; Joshua D Amos; Brice E Barefoot; Xi Chen; Thomas N Denny; Katherine R DeRosa; Mark S Drinker; Joshua A Eudailey; Andrew Foulger; Geoffrey S Ginsburg; Hana Golding; Thaddeus C Gurley; Garnett Kelsoe; Thomas B Kepler; Surender Khurana; Daniel M Kozink; Hua-Xin Liao; Dawn J Marshall; Micah T McClain; R Ryan Meyerhoff; Barton F Haynes
H3N2 influenza infection elicits more cross-reactive and less clonally expanded anti-hemagglutinin antibodies than influenza vaccination.
PloS one 2011;6(10):e25797.
2011: Lynn Morris; Robert Parks; Georgia D Tomaras; John Whitesides; Ruijun Zhang; Frederick Jaeger; Thomas B Kepler; Hua-Xin Liao; Dawn J Marshall; David Montefiori; M Anthony Moody; Salim S Abdool-Karim; Munir Alam; Mira Bilska; Bing Chen; Xi Chen; Michele Donathan; Andrew Foulger; Elin S Gray; Barton F Haynes
Isolation of a human anti-HIV gp41 membrane proximal region neutralizing antibody by antigen-specific single B cell sorting.
PloS one 2011;6(9):e23532.
2011: Kevin O Saunders; Cavin Ward-Caviness; Robert J Schutte; Stephanie A Freel; R Glenn Overman; Nathan M Thielman; Coleen K Cunningham; Thomas B Kepler; Georgia D Tomaras
Secretion of MIP-1β and MIP-1α by CD8(+) T-lymphocytes correlates with HIV-1 inhibition independent of coreceptor usage.
Cellular immunology 2011;266(2):154-64.
2010: Katia Koelle; Priya Khatri; Meredith Kamradt; Thomas B Kepler
A two-tiered model for simulating the ecological and evolutionary dynamics of rapidly evolving viruses, with an application to influenza.
Journal of the Royal Society, Interface / the Royal Society 2010;7(50):1257-74.
2010: Kyla M Bennett; John E Scarborough; Theodore N Pappas; Thomas B Kepler
Patient socioeconomic status is an independent predictor of operative mortality.
Annals of surgery 2010;252(3):552-7; discussion 557-8.
2010: Hua Tang; Weiping Cao; Sudhir Pai Kasturi; Rajesh Ravindran; Helder I Nakaya; Kousik Kundu; Niren Murthy; Thomas B Kepler; Bernard Malissen; Bali Pulendran
The T helper type 2 response to cysteine proteases requires dendritic cell-basophil cooperation via ROS-mediated signaling.
Nature immunology 2010;11(7):608-17.
2010: Debasish Sen; Luette Forrest; Thomas B Kepler; Ian Parker; Michael D Cahalan
Selective and site-specific mobilization of dermal dendritic cells and Langerhans cells by Th1- and Th2-polarizing adjuvants.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(18):8334-9.
2010: Thomas B Kepler; Colin Crossman; Robert Cook-Deegan
Metastasizing patent claims on BRCA1.
Genomics 2010;95(5):312-4.
2010: Benjamin G Vincent; Ellen F Young; Adam S Buntzman; Rosemary Stevens; Thomas B Kepler; Roland Tisch; Jeffrey Frelinger; Paul R Hess
Toxin-coupled MHC class I tetramers can specifically ablate autoreactive CD8+ T cells and delay diabetes in nonobese diabetic mice.
Journal of immunology (Baltimore, Md. : 1950) 2010;184(8):4196-204.
2010: Supriya Munshaw; Thomas B Kepler
SoDA2: a Hidden Markov Model approach for identification of immunoglobulin rearrangements.
Bioinformatics (Oxford, England) 2010;26(7):867-72.
2010: Thomas B Kepler; Christopher Sample; Kathryn Hudak; Jeffrey Roach; Albert Haines; Allyson Walsh; Elizabeth A Ramsburg
Chiropteran types I and II interferon genes inferred from genome sequencing traces by a statistical gene-family assembler.
BMC genomics 2010;11():444.
2010: Virginia B Kraus; Thomas B Kepler; Thomas Stabler; Jordan B Renner; Joanne M Jordan
First qualification study of serum biomarkers as indicators of total body burden of osteoarthritis.
PloS one 2010;5(3):e9739.
2009: Li Li; Qiuming He; Alaina Garland; Zuoan Yi; Lydia T Aybar; Thomas B Kepler; Jeffrey Frelinger; Bo Wang; Roland Tisch
beta cell-specific CD4+ T cell clonotypes in peripheral blood and the pancreatic islets are distinct.
Journal of immunology (Baltimore, Md. : 1950) 2009;183(11):7585-91.
2009: Stanca M Ciupe; Blythe H Devlin; M Louise Markert; Thomas B Kepler
The dynamics of T-cell receptor repertoire diversity following thymus transplantation for DiGeorge anomaly.
PLoS computational biology 2009;5(6):e1000396.
2009: Hua-Xin Liao; Marc C Levesque; Ashleigh Nagel; Ashlyn Dixon; Ruijun Zhang; Emmanuel Walter; Robert Parks; John Whitesides; Dawn J Marshall; Kwan-Ki Hwang; Yi Yang; Xi Chen; Feng Gao; Supriya Munshaw; Thomas B Kepler; Thomas Denny; M Anthony Moody; Barton F Haynes
High-throughput isolation of immunoglobulin genes from single human B cells and expression as monoclonal antibodies.
Journal of virological methods 2009;158(1-2):171-9.
2009: Joseph M Volpe; Thomas B Kepler
Genetic correlates of autoreactivity and autoreactive potential in human Ig heavy chains.
Immunome research 2009;5():1.
2008: Brice Barefoot; Natalie J Thornburg; Daniel H Barouch; Jae-Sung Yu; Christopher Sample; Robert E Johnston; Hua-Xin Liao; Thomas B Kepler; Barton F Haynes; Elizabeth Ramsburg
Comparison of multiple vaccine vectors in a single heterologous prime-boost trial.
Vaccine 2008;26(48):6108-18.
2008: Cliburn Chan; Feng Feng; Janet Ottinger; David Foster; Mike West; Thomas B Kepler
Statistical mixture modeling for cell subtype identification in flow cytometry.
Cytometry. Part A : the journal of the International Society for Analytical Cytology 2008;73(8):693-701.
2008: Katherine Buckley; S Munshaw; Thomas B Kepler; L Courtney Smith
The 185/333 gene family is a rapidly diversifying host-defense gene cluster in the purple sea urchin Strongylocentrotus purpuratus.
Journal of molecular biology 2008;379(4):912-28.
2008: David S Riddle; Peter J Miller; Benjamin G Vincent; Thomas B Kepler; Robert Maile; Jeffrey Frelinger; Edward J Collins
Rescue of cytotoxic function in the CD8alpha knockout mouse by removal of MHC class II.
European journal of immunology 2008;38(6):1511-21.
2008: Supriya Munshaw; Thomas B Kepler
An information-theoretic method for the treatment of plural ancestry in phylogenetics.
Molecular biology and evolution 2008;25(6):1199-208.
2008: Ana Paula Sales; Georgia D Tomaras; Thomas B Kepler
Improving peptide-MHC class I binding prediction for unbalanced datasets.
BMC bioinformatics 2008;9():385.
2008: Jacob Frelinger; Thomas B Kepler; Cliburn Chan
Flow: Statistics, visualization and informatics for flow cytometry.
Source code for biology and medicine 2008;3():10.
2008: Faheem Mitha; Timothy A Lucas; Feng Feng; Thomas B Kepler; Cliburn Chan
The Multiscale Systems Immunology project: software for cell-based immunological simulation.
Source code for biology and medicine 2008;3():6.
2008: Joseph M Volpe; Thomas B Kepler
Large-scale analysis of human heavy chain V(D)J recombination patterns.
Immunome research 2008;4():3.
2007: M Louise Markert; Blythe H Devlin; Marilyn J Alexieff; Jie Li; Elizabeth A McCarthy; Stephanie E Gupton; Ivan K Chinn; Laura P Hale; Thomas B Kepler; Min He; Marcella Sarzotti; Michael A Skinner; Henry E Rice; Jeffrey C Hoehner
Review of 54 patients with complete DiGeorge anomaly enrolled in protocols for thymus transplantation: outcome of 44 consecutive transplants.
Blood 2007;109(10):4539-47.
2007: Thomas B Kepler; Cliburn Chan
Spatiotemporal programming of a simple inflammatory process.
Immunological reviews 2007;216():153-63.
2007: Cliburn Chan; Thomas B Kepler
Computational immunology--from bench to virtual reality.
Annals of the Academy of Medicine, Singapore 2007;36(2):123-7.
2007: Surajit Ray; Thomas B Kepler
Amino acid biophysical properties in the statistical prediction of peptide-MHC class I binding.
Immunome research 2007;3():9.
2007: Donna A Culton; Matilda W Nicholas; Donna Bunch; Quan Li Zhen; Thomas B Kepler; Mary Anne Dooley; Chandra Mohan; Patrick H Nachman; Stephen H Clarke
Similar CD19 dysregulation in two autoantibody-associated autoimmune diseases suggests a shared mechanism of B-cell tolerance loss.
Journal of clinical immunology 2007;27(1):53-68.
2006: Douglas Charles Bauer; D J Hunter; Steven B Abramson; Mukundan Attur; M Corr; David T Felson; D Heinegård; Joanne M Jordan; Thomas B Kepler; Nancy E Lane; Dick Heinegård; B Tyree; Virginia B Kraus
Classification of osteoarthritis biomarkers: a proposed approach.
Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society 2006;14(8):723-7.
2006: Congxiao Liu; Min He; Barbara Alexander Rooney; Thomas B Kepler; Nelson J Chao
Longitudinal analysis of T-cell receptor variable beta chain repertoire in patients with acute graft-versus-host disease after allogeneic stem cell transplantation.
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 2006;12(3):335-45.
2006: Joseph M Volpe; Lindsay G Cowell; Thomas B Kepler
SoDA: implementation of a 3D alignment algorithm for inference of antigen receptor recombinations.
Bioinformatics (Oxford, England) 2006;22(4):438-44.
2006: Shaza A Fadel; Lindsay G Cowell; Shui Cao; Daniel A Ozaki; Thomas B Kepler; Douglas A Steeber; Marcella Sarzotti
Neonate-primed CD8+ memory cells rival adult-primed memory cells in antigen-driven expansion and anti-viral protection.
International immunology 2006;18(2):249-57.
2005: Min He; John K Tomfohr; Blythe H Devlin; Marcella Sarzotti; M Louise Markert; Thomas B Kepler
SpA: web-accessible spectratype analysis: data management, statistical analysis and visualization.
Bioinformatics (Oxford, England) 2005;21(18):3697-9.
2005: Thomas B Kepler; Min He; John K Tomfohr; Blythe H Devlin; Marcella Sarzotti; M Louise Markert
Statistical analysis of antigen receptor spectratype data.
Bioinformatics (Oxford, England) 2005;21(16):3394-400.
2005: John K Tomfohr; Jun Lu; Thomas B Kepler
Pathway level analysis of gene expression using singular value decomposition.
BMC bioinformatics 2005;6():225.
2005: Jun Lu; John K Tomfohr; Thomas B Kepler
Identifying differential expression in multiple SAGE libraries: an overdispersed log-linear model approach.
BMC bioinformatics 2005;6():165.
2004: Jason Smith; John K Tomfohr; Matthew C Wells; Thomas P Beebe; Thomas B Kepler; William M Reichert
Measurement of cell migration on surface-bound fibronectin gradients.
Langmuir : the ACS journal of surfaces and colloids 2004;20(19):8279-86.
2004: Si-Ming Zhang; Coen Adema; Thomas B Kepler; Eric S Loker
Diversification of Ig superfamily genes in an invertebrate.
Science (New York, N.Y.) 2004;305(5681):251-4.
2004: Eric S Loker; Coen Adema; Si-Ming Zhang; Thomas B Kepler
Invertebrate immune systems--not homogeneous, not simple, not well understood.
Immunological reviews 2004;198():10-24.
2004: Feng Gao; Yalu Chen; David N Levy; Joan A Conway; Thomas B Kepler; Huxiong Hui
Unselected mutations in the human immunodeficiency virus type 1 genome are mostly nonsynonymous and often deleterious.
Journal of virology 2004;78(5):2426-33.
2003: Simona Bartl; Ann L Miracle; Lynn L Rumfelt; Thomas B Kepler; Evonne Mochon; Gary W Litman; Martin F Flajnik
Terminal deoxynucleotidyl transferases from elasmobranchs reveal structural conservation within vertebrates.
Immunogenetics 2003;55(9):594-604.
2003: Elizabeth Trachtenberg; Bette Korber; Cristina Sollars; Thomas B Kepler; Peter T Hraber; Elizabeth Hayes; Robert Funkhouser; Michael Fugate; James Theiler; Yen S Hsu; Kevin Kunstman; Samuel Wu; John Phair; Henry A Erlich; Steven Wolinsky
Advantage of rare HLA supertype in HIV disease progression.
Nature medicine 2003;9(7):928-35.
2003: Lindsay G Cowell; Marco Davila; Kaiyong Yang; Thomas B Kepler; Garnett Kelsoe
Prospective estimation of recombination signal efficiency and identification of functional cryptic signals in the genome by statistical modeling.
The Journal of experimental medicine 2003;197(2):207-20.
2002: Kevin T Morgan; Hong Ni; H Roger Brown; Lawrence Yoon; Charles W Qualls; Lynn M Crosby; Randall Reynolds; Betty Gaskill; Anderson Steven; Thomas B Kepler; Tracy Brainard; Nik Liv; Marilyn Easton; Christine L Merrill; Donald R Creech; Dirk Sprenger; Gary Conner; Paul R Johnson; Tony Fox; Maureen Sartor; Erika Richard; Sabu Kuruvilla; Warren Casey; Gina B Benavides
Application of cDNA microarray technology to in vitro toxicology and the selection of genes for a real-time RT-PCR-based screen for oxidative stress in Hep-G2 cells.
Toxicologic pathology 2002;30(4):435-51.
2002: Thomas B Kepler; Lynn Crosby; Kevin T Morgan
Normalization and analysis of DNA microarray data by self-consistency and local regression.
Genome biology 2002;3(7):RESEARCH0037.
2002: Lindsay G Cowell; Marco Davila; Thomas B Kepler; Garnett Kelsoe
Identification and utilization of arbitrary correlations in models of recombination signal sequences.
Genome biology 2002;3(12):RESEARCH0072.
2001: Thomas B Kepler; Timothy C Elston
Stochasticity in transcriptional regulation: origins, consequences, and mathematical representations.
Biophysical journal 2001;81(6):3116-36.
2001: Mihaela Zavolan; Thomas B Kepler
Statistical inference of sequence-dependent mutation rates.
Current opinion in genetics & development 2001;11(6):612-5.
2001: Timothy G Buchman; J P Cobb; A S Lapedes; Thomas B Kepler
Complex systems analysis: a tool for shock research.
Shock (Augusta, Ga.) 2001;16(4):248-51.
2001: M D Radmacher; Thomas B Kepler
Waiting times to appearance and dominance of advantageous mutants: estimation based on the likelihood.
Mathematical biosciences 2001;170(1):59-77.
2001: M Oprea; Thomas B Kepler
Improved inference of mutation rates: II. Generalization of the Luria-Delbrück distribution for realistic cell-cycle time distributions.
Theoretical population biology 2001;59(1):49-59.
2001: Thomas B Kepler; M Oprea
Improved inference of mutation rates: I. An integral representation for the Luria-Delbrück distribution.
Theoretical population biology 2001;59(1):41-8.
2001: M Oprea; Lindsay G Cowell; Thomas B Kepler
The targeting of somatic hypermutation closely resembles that of meiotic mutation.
Journal of immunology (Baltimore, Md. : 1950) 2001;166(2):892-9.
2000: Lynn M Crosby; K S Hyder; Anthony B DeAngelo; Thomas B Kepler; Betty Gaskill; Gina R Benavides; Lawrence Yoon; Kevin T Morgan
Morphologic analysis correlates with gene expression changes in cultured F344 rat mesothelial cells.
Toxicology and applied pharmacology 2000;169(3):205-21.
2000: Lindsay G Cowell; Thomas B Kepler
The nucleotide-replacement spectrum under somatic hypermutation exhibits microsequence dependence that is strand-symmetric and distinct from that under germline mutation.
Journal of immunology (Baltimore, Md. : 1950) 2000;164(4):1971-6.
2000: D A Keys; D G Wallace; Thomas B Kepler; R B Conolly
Quantitative evaluation of alternative mechanisms of blood disposition of di(n-butyl) phthalate and mono(n-butyl) phthalate in rats.
Toxicological sciences : an official journal of the Society of Toxicology 2000;53(2):173-84.
1999: M Oprea; Thomas B Kepler
Genetic plasticity of V genes under somatic hypermutation: statistical analyses using a new resampling-based methodology.
Genome research 1999;9(12):1294-304.
1999: MR Betts; JF Krowka; Thomas B Kepler; M Davidian; C Christopherson; S Kwok; L Louie; Joseph J Eron; Haynes W Sheppard; Jeffrey Frelinger
Human immunodeficiency virus type 1-specific cytotoxic T lymphocyte activity is inversely correlated with HIV type 1 viral load in HIV type 1-infected long-term survivors.
AIDS research and human retroviruses 1999;15(13):1219-28.
1999: Lindsay G Cowell; H J Kim; T Humaljoki; C Berek; Thomas B Kepler
Enhanced evolvability in immunoglobulin V genes under somatic hypermutation.
Journal of molecular evolution 1999;49(1):23-6.
1999: D A Keys; D G Wallace; Thomas B Kepler; R B Conolly
Quantitative evaluation of alternative mechanisms of blood and testes disposition of di(2-ethylhexyl) phthalate and mono(2-ethylhexyl) phthalate in rats.
Toxicological sciences : an official journal of the Society of Toxicology 1999;49(2):172-85.
1999: L Gangi-Peterson; D H Sorscher; J W Reynolds; Thomas B Kepler; Beverly S Mitchell
Nucleotide pool imbalance and adenosine deaminase deficiency induce alterations of N-region insertions during V(D)J recombination.
The Journal of clinical investigation 1999;103(6):833-41.
1998: Thomas B Kepler; A S Perelson
Drug concentration heterogeneity facilitates the evolution of drug resistance.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(20):11514-9.
1998: M D Radmacher; Garnett Kelsoe; Thomas B Kepler
Predicted and inferred waiting times for key mutations in the germinal centre reaction: evidence for stochasticity in selection.
Immunology and cell biology 1998;76(4):373-81.
1998: Lindsay G Cowell; Thomas B Kepler; M Janitz; Roland Lauster; NA Mitchison
The distribution of variation in regulatory gene segments, as present in MHC class II promoters.
Genome research 1998;8(2):124-34.
1998: Thomas B Kepler; Simona Bartl
Plasticity under somatic mutation in antigen receptors.
Current topics in microbiology and immunology 1998;229():149-62.
1997: Thomas B Kepler
Codon bias and plasticity in immunoglobulins.
Molecular biology and evolution 1997;14(6):637-43.
1996: Thomas B Kepler; M Borrero; B Rugerio; S K McCray; Stephen H Clarke
Interdependence of N nucleotide addition and recombination site choice in V(D)J rearrangement.
Journal of immunology (Baltimore, Md. : 1950) 1996;157(10):4451-7.
1995: Thomas B Kepler; A S Perelson
Modeling and optimization of populations subject to time-dependent mutation.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(18):8219-23.
1995: S Han; Karen S Hathcock; B Zheng; Thomas B Kepler; Richard J Hodes; Garnett Kelsoe
Cellular interaction in germinal centers. Roles of CD40 ligand and B7-2 in established germinal centers.
Journal of immunology (Baltimore, Md. : 1950) 1995;155(2):556-67.
1993: Thomas B Kepler; A S Perelson
Somatic hypermutation in B cells: an optimal control treatment.
Journal of theoretical biology 1993;164(1):37-64.
1993: Thomas B Kepler; A S Perelson
Cyclic re-entry of germinal center B cells and the efficiency of affinity maturation.
Immunology today 1993;14(8):412-5.
1993: Thomas B Kepler; Eve Marder
Spike initiation and propagation on axons with slow inward currents.
Biological cybernetics 1993;68(3):209-14.
1992: Thomas B Kepler; LF Abbott; Eve Marder
Reduction of conductance-based neuron models.
Biological cybernetics 1992;66(5):381-7.
1991: M L Kagan; Thomas B Kepler; I R Epstein
Geometric phase shifts in chemical oscillators.
Nature 1991;349(6309):506-8.
1990: Thomas B Kepler; Eve Marder; LF Abbott
The effect of electrical coupling on the frequency of model neuronal oscillators.
Science (New York, N.Y.) 1990;248(4951):83-5.