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Richard H. Ebright

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Chemicals & Drugs

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Escherichia coli

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Physiology

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Protein Binding

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Publications

TOP 3
Yu Zhang; Eddy Arnold; Sujoy Chatterjee; Yu Feng; Mary X Ho; Steve Tuske; Richard H. Ebright
Structural basis of transcription initiation.
Anirban Chakraborty; Saikat Chowdhury; Yon W Ebright; Herbert Irschik; Rolf Jansen; Taiho Kim; Jennifer Knight; You Korlann; Ekaterine Kortkhonjia; B Tracy Nixon; Dongye Wang; Shimon Weiss; Siva Wigneshweraraj; Richard H. Ebright
Opening and closing of the bacterial RNA polymerase clamp.
Ron Fouchier; D A Henderson; Richard H. Ebright; Lynn Klotz; A B Osterhaus; John Steinbruner; Ed Sylvester; Jeffery K Taubenberger; Kwok-Yung Yuen; David L Heymann
Preventing pandemics: The fight over flu.

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All Publications

2012: Yu Zhang; Eddy Arnold; Sujoy Chatterjee; Yu Feng; Mary X Ho; Steve Tuske; Richard H. Ebright
Structural basis of transcription initiation.
Science (New York, N.Y.) 2012;338(6110):1076-80.
2012: Anirban Chakraborty; Saikat Chowdhury; Yon W Ebright; Herbert Irschik; Rolf Jansen; Taiho Kim; Jennifer Knight; You Korlann; Ekaterine Kortkhonjia; B Tracy Nixon; Dongye Wang; Shimon Weiss; Siva Wigneshweraraj; Richard H. Ebright
Opening and closing of the bacterial RNA polymerase clamp.
Science (New York, N.Y.) 2012;337(6094):591-5.
2012: Ron Fouchier; D A Henderson; Richard H. Ebright; Lynn Klotz; A B Osterhaus; John Steinbruner; Ed Sylvester; Jeffery K Taubenberger; Kwok-Yung Yuen; David L Heymann
Preventing pandemics: The fight over flu.
Nature 2012;481(7381):257-9.
2011: Konstantin Kuznedelov; Mohamed A Marahiel; Damir Mukhamedyarov; Ekaterina Semenova; Sujoy Chatterjee; Richard H. Ebright; Thomas A Knappe; Aashish Srivastava; Konstantin Severinov
The antibacterial threaded-lasso peptide capistruin inhibits bacterial RNA polymerase.
Journal of molecular biology 2011;412(5):842-8.
2011: Aashish Srivastava; Meliza Talaue; Cai Xin; Alex Zozula; Anirban Chakraborty; Sujoy Chatterjee; Nancy Connell; David Degen; Stefano Donadio; Sergey Y Druzhinin; Richard Y Ebright; Yon W Ebright; Herbert Irschik; Rolf Jansen; Takushi Kaneko; Shuang Liu; Jayanta Mukhopadhyay; Rui Rong Niedfeldt; Sonali Sengupta; Juan Shen; Elena Sineva; Richard H. Ebright
New target for inhibition of bacterial RNA polymerase: 'switch region'.
Current opinion in microbiology 2011;14(5):532-43.
2011: Yao Xiao; Xueming Wei; Richard H. Ebright; Daniel Wall
Antibiotic production by myxobacteria plays a role in predation.
Journal of bacteriology 2011;193(18):4626-33.
2011: Dina Grohmann; Daniel Klose; Jens Michaelis; Julia Nagy; Anirban Chakraborty; Richard H. Ebright; Daniel Fielden; Finn Werner
The initiation factor TFE and the elongation factor Spt4/5 compete for the RNAP clamp during transcription initiation and elongation.
Molecular cell 2011;43(2):263-74.
2010: Anirban Chakraborty; Dongye Wang; Yon W Ebright; Richard H. Ebright
Azide-specific labeling of biomolecules by Staudinger-Bertozzi ligation phosphine derivatives of fluorescent probes suitable for single-molecule fluorescence spectroscopy.
Methods in enzymology 2010;472():19-30.
2009: Mary X Ho; Brian P Hudson; Kalyan Das; Eddy Arnold; Richard H. Ebright
Structures of RNA polymerase-antibiotic complexes.
Current opinion in structural biology 2009;19(6):715-23.
2009: Brian P Hudson; Joel Quispe; Samuel Lara-González; Younggyu Kim; Helen Berman; Eddy Arnold; Richard H. Ebright; Catherine L Lawson
Three-dimensional EM structure of an intact activator-dependent transcription initiation complex.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(47):19830-5.
2009: Seth R Goldman; Richard H. Ebright; Bryce E Nickels
Direct detection of abortive RNA transcripts in vivo.
Science (New York, N.Y.) 2009;324(5929):927-8.
2009: Nataliya Popovych; Shiou-Ru Tzeng; Marco Tonelli; Richard H. Ebright; Charalampos G Kalodimos
Structural basis for cAMP-mediated allosteric control of the catabolite activator protein.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(17):6927-32.
2009: Nikolai Naryshkin; Sergei Druzhinin; Andrei Revyakin; Younggyu Kim; Vladimir Mekler; Richard H. Ebright
Static and kinetic site-specific protein-DNA photocrosslinking: analysis of bacterial transcription initiation complexes.
Methods in molecular biology (Clifton, N.J.) 2009;543():403-37.
2008: Younggyu Kim; Yon W Ebright; Adam R Goodman; Danny Reinberg; Richard H. Ebright
Nonradioactive, ultrasensitive site-specific protein-protein photocrosslinking: interactions of alpha-helix 2 of TATA-binding protein with general transcription factor TFIIA and transcriptional repressor NC2.
Nucleic acids research 2008;36(19):6143-54.
2008: Jayanta Mukhopadhyay; Kalyan Das; Sajida Ismail; David Koppstein; Minyoung Jang; Brian Hudson; Stefan G Sarafianos; Steve Tuske; Jay Patel; Rolf Jansen; Herbert Irschik; Eddy Arnold; Richard H. Ebright
The RNA polymerase "switch region" is a target for inhibitors.
Cell 2008;135(2):295-307.
2008: Andrey Feklistov; Vladimir Mekler; Qiaorong Jiang; Lars F Westblade; Herbert Irschik; Rolf Jansen; Arkady Mustaev; Seth A Darst; Richard H. Ebright
Rifamycins do not function by allosteric modulation of binding of Mg2+ to the RNA polymerase active center.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(39):14820-5.
2008: Olga Pavlova; Jayanta Mukhopadhyay; Elena Sineva; Richard H. Ebright; Konstantin Severinov
Systematic structure-activity analysis of microcin J25.
The Journal of biological chemistry 2008;283(37):25589-95.
2007: Sara Cellai; Laura Mangiarotti; Nicola Vannini; Nikolai Naryshkin; Ekaterine Kortkhonjia; Richard H. Ebright; Claudio Rivetti
Upstream promoter sequences and alphaCTD mediate stable DNA wrapping within the RNA polymerase-promoter open complex.
EMBO reports 2007;8(3):271-8.
2006: Achillefs N Kapanidis; Emmanuel Margeat; Sam On Ho; Ekaterine Kortkhonjia; Shimon Weiss; Richard H. Ebright
Initial transcription by RNA polymerase proceeds through a DNA-scrunching mechanism.
Science (New York, N.Y.) 2006;314(5802):1144-7.
2006: Andrey Revyakin; Chenyu Liu; Richard H. Ebright; Terence Strick
Abortive initiation and productive initiation by RNA polymerase involve DNA scrunching.
Science (New York, N.Y.) 2006;314(5802):1139-43.
2006: Nataliya Popovych; Shangjin Sun; Richard H. Ebright; Charalampos G Kalodimos
Dynamically driven protein allostery.
Nature structural & molecular biology 2006;13(9):831-8.
2006: Vasisht R Tadigotla; Dáibhid O Maoiléidigh; Anirvan M Sengupta; Vitaly Epshtein; Richard H. Ebright; Evgeny Nudler; Andrei E Ruckenstein
Thermodynamic and kinetic modeling of transcriptional pausing.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(12):4439-44.
2006: Andrew Napoli; Catherine L Lawson; Richard H. Ebright; Helen M Berman
Indirect readout of DNA sequence at the primary-kink site in the CAP-DNA complex: recognition of pyrimidine-purine and purine-purine steps.
Journal of molecular biology 2006;357(1):173-83.
2006: Emmanuel Margeat; Achillefs N Kapanidis; Philip Tinnefeld; You Wang; Jayanta Mukhopadhyay; Richard H. Ebright; Shimon Weiss
Direct observation of abortive initiation and promoter escape within single immobilized transcription complexes.
Biophysical journal 2006;90(4):1419-31.
2006: Nikolai Naryshkin; Andrey Revyakin; Richard H. Ebright
Site-specific protein-DNA photo-cross-linking: analysis of structural organization of protein-DNA and multiprotein-DNA complexes.
CSH protocols 2006;2006(6):.
2005: Achillefs N Kapanidis; Emmanuel Margeat; Ted A Laurence; Sören Doose; Sam On Ho; Jayanta Mukhopadhyay; Ekaterine Kortkhonjia; Vladimir Mekler; Richard H. Ebright; Shimon Weiss
Retention of transcription initiation factor sigma70 in transcription elongation: single-molecule analysis.
Molecular cell 2005;20(3):347-56.
2005: Catherine E Vrentas; Tamas Gaal; Wilma Ross; Richard H. Ebright; Richard L Gourse
Response of RNA polymerase to ppGpp: requirement for the omega subunit and relief of this requirement by DksA.
Genes & development 2005;19(19):2378-87.
2005: Steve Tuske; Stefan G Sarafianos; Xinyue Wang; Brian Hudson; Elena Sineva; Jayanta Mukhopadhyay; Jens J Birktoft; Olivier Leroy; Sajida Ismail; Arthur D Clark; Chhaya Dharia; Andrew Napoli; Oleg Laptenko; Jookyung Lee; Sergei Borukhov; Richard H. Ebright; Eddy Arnold
Inhibition of bacterial RNA polymerase by streptolydigin: stabilization of a straight-bridge-helix active-center conformation.
Cell 2005;122(4):541-52.
2005: Nam Ki Lee; Achillefs N Kapanidis; You Wang; Xavier Michalet; Jayanta Mukhopadhyay; Richard H. Ebright; Shimon Weiss
Accurate FRET measurements within single diffusing biomolecules using alternating-laser excitation.
Biophysical journal 2005;88(4):2939-53.
2005: Bryce E Nickels; Sean J Garrity; Vladimir Mekler; Leonid Minakhin; Konstantin Severinov; Richard H. Ebright; Ann Hochschild
The interaction between sigma70 and the beta-flap of Escherichia coli RNA polymerase inhibits extension of nascent RNA during early elongation.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(12):4488-93.
2005: Sidney Altman; Bonnie L Bassler; Jon Beckwith; Marlene Belfort; Howard C Berg; Barry Bloom; Jean E Brenchley; Allan Campbell; R. John Collier; Nancy Connell; Nicholas R Cozzarelli; Nancy Craig; Seth Darst; Richard H. Ebright; Stephen J Elledge; Stanley Falkow; Jorge E Galan; Max Gottesman; Richard Gourse; Nigel D F Grindley; Carol A Gross; Alan Grossman; Ann Hochschild; Martha Howe; Jerard Hurwitz; Ralph R Isberg; Samuel Kaplan; Arthur Kornberg; Sydney G Kustu; Robert C Landick; Arthur Landy; Stuart B Levy; Richard Losick; Sharon R Long; Stanley R Maloy; John J Mekalanos; Frederick C Neidhardt; Norman R Pace; Mark Ptashne; Jeffrey W Roberts; John R Roth; Lucia B Rothman-Denes; Abigail A Salyers; Moselio Schaechter; Lucy Shapiro; Thomas J Silhavy; Melvin I Simon; Graham C Walker; Charles Yanofsky; Norton Zinder
An open letter to Elias Zerhouni.
Science (New York, N.Y.) 2005;307(5714):1409-10.
2005: Andrey Revyakin; Richard H. Ebright; Terence Strick
Single-molecule DNA nanomanipulation: improved resolution through use of shorter DNA fragments.
Nature methods 2005;2(2):127-38.
2005: Jennifer L Knight; Vladimir Mekler; Jayanta Mukhopadhyay; Richard H. Ebright; Ronald M Levy
Distance-restrained docking of rifampicin and rifamycin SV to RNA polymerase using systematic FRET measurements: developing benchmarks of model quality and reliability.
Biophysical journal 2005;88(2):925-38.
2004: Jayanta Mukhopadhyay; Elena Sineva; Jennifer Knight; Ronald M Levy; Richard H. Ebright
Antibacterial peptide microcin J25 inhibits transcription by binding within and obstructing the RNA polymerase secondary channel.
Molecular cell 2004;14(6):739-51.
2004: Bryce E Nickels; Jayanta Mukhopadhyay; Sean J Garrity; Richard H. Ebright; Ann Hochschild
The sigma 70 subunit of RNA polymerase mediates a promoter-proximal pause at the lac promoter.
Nature structural & molecular biology 2004;11(6):544-50.
2004: Andrey Revyakin; Richard H. Ebright; Terence Strick
Promoter unwinding and promoter clearance by RNA polymerase: detection by single-molecule DNA nanomanipulation.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(14):4776-80.
2004: Catherine L Lawson; David Swigon; Katsuhiko S Murakami; Seth A Darst; Helen M Berman; Richard H. Ebright
Catabolite activator protein: DNA binding and transcription activation.
Current opinion in structural biology 2004;14(1):10-20.
2004: Matthew B Renfrow; Nikolai Naryshkin; L Michelle Lewis; Hung-Ta Chen; Richard H. Ebright; Robert A Scott
Transcription factor B contacts promoter DNA near the transcription start site of the archaeal transcription initiation complex.
The Journal of biological chemistry 2004;279(4):2825-31.
2003: Marvin J Bayro; Jayanta Mukhopadhyay; G V T Swapna; Janet Y Huang; Li-Chung Ma; Elena Sineva; Philip E Dawson; Gaetano T Montelione; Richard H. Ebright
Structure of antibacterial peptide microcin J25: a 21-residue lariat protoknot.
Journal of the American Chemical Society 2003;125(41):12382-3.
2003: Hao Chen; Hong Tang; Richard H. Ebright
Functional interaction between RNA polymerase alpha subunit C-terminal domain and sigma70 in UP-element- and activator-dependent transcription.
Molecular cell 2003;11(6):1621-33.
2003: Jayanta Mukhopadhyay; Vladimir Mekler; Ekaterine Kortkhonjia; Achillefs N Kapanidis; Yon W Ebright; Richard H. Ebright
Fluorescence resonance energy transfer (FRET) in analysis of transcription-complex structure and function.
Methods in enzymology 2003;371():144-59.
2003: Andrey Revyakin; Jean-François Allemand; Vincent Croquette; Richard H. Ebright; Terence Strick
Single-molecule DNA nanomanipulation: detection of promoter-unwinding events by RNA polymerase.
Methods in enzymology 2003;370():577-98.
2002: Georgina S Lloyd; Wei Niu; John Tebbutt; Richard H. Ebright; Stephen J W Busby
Requirement for two copies of RNA polymerase alpha subunit C-terminal domain for synergistic transcription activation at complex bacterial promoters.
Genes & development 2002;16(19):2557-65.
2002: Brian Benoff; Huanwang Yang; Catherine L Lawson; Gary Parkinson; Jinsong Liu; Erich Blatter; Yon W Ebright; Helen M Berman; Richard H. Ebright
Structural basis of transcription activation: the CAP-alpha CTD-DNA complex.
Science (New York, N.Y.) 2002;297(5586):1562-6.
2002: Nigel J Savery; Georgina S Lloyd; Stephen J W Busby; Mark S Thomas; Richard H. Ebright; Richard L Gourse
Determinants of the C-terminal domain of the Escherichia coli RNA polymerase alpha subunit important for transcription at class I cyclic AMP receptor protein-dependent promoters.
Journal of bacteriology 2002;184(8):2273-80.
2002: Vladimir Mekler; Ekaterine Kortkhonjia; Jayanta Mukhopadhyay; Jennifer Knight; Andrey Revyakin; Achillefs N Kapanidis; Wei Niu; Yon W Ebright; Ronald Levy; Richard H. Ebright
Structural organization of bacterial RNA polymerase holoenzyme and the RNA polymerase-promoter open complex.
Cell 2002;108(5):599-614.
2002: Richard H. Ebright; Nancy Connell
Bioweapon agents: more access means more risk.
Nature 2002;415(6870):364.
2001: Achillefs N Kapanidis; Yon W Ebright; Richard H. Ebright
Site-specific incorporation of fluorescent probes into protein: hexahistidine-tag-mediated fluorescent labeling with (Ni(2+):nitrilotriacetic Acid (n)-fluorochrome conjugates.
Journal of the American Chemical Society 2001;123(48):12123-5.
2001: S Chen; A Gunasekera; X Zhang; T A Kunkel; Richard H. Ebright; Helen M Berman
Indirect readout of DNA sequence at the primary-kink site in the CAP-DNA complex: alteration of DNA binding specificity through alteration of DNA kinking.
Journal of molecular biology 2001;314(1):75-82.
2001: S Chen; J Vojtechovsky; G N Parkinson; Richard H. Ebright; Helen M Berman
Indirect readout of DNA sequence at the primary-kink site in the CAP-DNA complex: DNA binding specificity based on energetics of DNA kinking.
Journal of molecular biology 2001;314(1):63-74.
2001: Achillefs N Kapanidis; Yon W Ebright; R D Ludescher; S Chan; Richard H. Ebright
Mean DNA bend angle and distribution of DNA bend angles in the CAP-DNA complex in solution.
Journal of molecular biology 2001;312(3):453-68.
2001: Jayanta Mukhopadhyay; Achillefs N Kapanidis; Vladimir Mekler; Ekaterine Kortkhonjia; Yon W Ebright; Richard H. Ebright
Translocation of sigma(70) with RNA polymerase during transcription: fluorescence resonance energy transfer assay for movement relative to DNA.
Cell 2001;106(4):453-63.
2001: Leonid Minakhin; S Bhagat; A Brunning; Elizabeth A Campbell; Seth A Darst; Richard H. Ebright; Konstantin Severinov
Bacterial RNA polymerase subunit omega and eukaryotic RNA polymerase subunit RPB6 are sequence, structural, and functional homologs and promote RNA polymerase assembly.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(3):892-7.
2001: Nikolai Naryshkin; Y Kim; Q Dong; Richard H. Ebright
Site-specific protein-DNA photocrosslinking. Analysis of bacterial transcription initiation complexes.
Methods in molecular biology (Clifton, N.J.) 2001;148():337-61.
2000: Richard H. Ebright
RNA polymerase: structural similarities between bacterial RNA polymerase and eukaryotic RNA polymerase II.
Journal of molecular biology 2000;304(5):687-98.
2000: Nikolai Naryshkin; Andrey Revyakin; Y Kim; Vladimir Mekler; Richard H. Ebright
Structural organization of the RNA polymerase-promoter open complex.
Cell 2000;101(6):601-11.
2000: Tae-kyung Kim; Richard H. Ebright; Danny Reinberg
Mechanism of ATP-dependent promoter melting by transcription factor IIH.
Science (New York, N.Y.) 2000;288(5470):1418-22.
2000: K L Meibom; Birgitte H Kallipolitis; Richard H. Ebright; Poul Valentin-Hansen
Identification of the subunit of cAMP receptor protein (CRP) that functionally interacts with CytR in CRP-CytR-mediated transcriptional repression.
The Journal of biological chemistry 2000;275(16):11951-6.
2000: L A Boyer; X Shao; Richard H. Ebright; Craig L Peterson
Roles of the histone H2A-H2B dimers and the (H3-H4)(2) tetramer in nucleosome remodeling by the SWI-SNF complex.
The Journal of biological chemistry 2000;275(16):11545-52.
2000: Qian Tan; K L Linask; Richard H. Ebright; Nancy A Woychik
Activation mutants in yeast RNA polymerase II subunit RPB3 provide evidence for a structurally conserved surface required for activation in eukaryotes and bacteria.
Genes & development 2000;14(3):339-48.
1999: Stephen Busby; Richard H. Ebright
Transcription activation by catabolite activator protein (CAP).
Journal of molecular biology 1999;293(2):199-213.
1999: ST Estrem; Wilma Ross; Tamas Gaal; Z W Chen; W Niu; Richard H. Ebright; Richard L Gourse
Bacterial promoter architecture: subsite structure of UP elements and interactions with the carboxy-terminal domain of the RNA polymerase alpha subunit.
Genes & development 1999;13(16):2134-47.
1999: P Harrison-McMonagle; Natalia G Denissova; E Martínez-Hackert; Richard H. Ebright; Ann M Stock
Orientation of OmpR monomers within an OmpR:DNA complex determined by DNA affinity cleaving.
Journal of molecular biology 1999;285(2):555-66.
1998: SM Sullivan; PJ Horn; V A Olson; A H Koop; W Niu; Richard H. Ebright; Steven J Triezenberg
Mutational analysis of a transcriptional activation region of the VP16 protein of herpes simplex virus.
Nucleic acids research 1998;26(19):4487-96.
1998: Nigel J Savery; Georgina S Lloyd; M Kainz; Tamas Gaal; Wilma Ross; Richard H. Ebright; Richard L Gourse; Stephen J W Busby
Transcription activation at Class II CRP-dependent promoters: identification of determinants in the C-terminal domain of the RNA polymerase alpha subunit.
The EMBO journal 1998;17(12):3439-47.
1998: Arnold J Berk; Thomas Boyer; Achillefs N Kapanidis; Richard H. Ebright; N N Kobayashi; PJ Horn; SM Sullivan; R Koop; M A Surby; Steven J Triezenberg
Mechanisms of viral activators.
Cold Spring Harbor symposia on quantitative biology 1998;63():243-52.
1998: Danny Reinberg; George Orphanides; Richard H. Ebright; S Akoulitchev; J Carcamo; Helen Cho; Patricia Cortes; Ronny Drapkin; O Flores; I Ha; J A Inostroza; Sungjoon Kim; Tae-kyung Kim; P Kumar; T Lagrange; Gary LeRoy; H Lu; D M Ma; E Maldonado; A Merino; F Mermelstein; I Olave; M Sheldon; Ramin Shiekhattar; L Zawel
The RNA polymerase II general transcription factors: past, present, and future.
Cold Spring Harbor symposia on quantitative biology 1998;63():83-103.
1998: Richard H. Ebright
RNA polymerase-DNA interaction: structures of intermediate, open, and elongation complexes.
Cold Spring Harbor symposia on quantitative biology 1998;63():11-20.
1998: T Lagrange; Achillefs N Kapanidis; H Tang; Danny Reinberg; Richard H. Ebright
New core promoter element in RNA polymerase II-dependent transcription: sequence-specific DNA binding by transcription factor IIB.
Genes & development 1998;12(1):34-44.
1997: Tae-kyung Kim; T Lagrange; Yuh-Hwa Wang; Jack D Griffith; Danny Reinberg; Richard H. Ebright
Trajectory of DNA in the RNA polymerase II transcription preinitiation complex.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(23):12268-73.
1997: A Miller; D Wood; Richard H. Ebright; Lucia B Rothman-Denes
RNA polymerase beta' subunit: a target of DNA binding-independent activation.
Science (New York, N.Y.) 1997;275(5306):1655-7.
1997: Stephen Busby; Richard H. Ebright
Transcription activation at class II CAP-dependent promoters.
Molecular microbiology 1997;23(5):853-9.
1996: W Niu; Y Kim; G Tau; Tomasz Heyduk; Richard H. Ebright
Transcription activation at class II CAP-dependent promoters: two interactions between CAP and RNA polymerase.
Cell 1996;87(6):1123-34.
1996: T Lagrange; Tae-kyung Kim; George Orphanides; Y W Ebright; Richard H. Ebright; Danny Reinberg
High-resolution mapping of nucleoprotein complexes by site-specific protein-DNA photocrosslinking: organization of the human TBP-TFIIA-TFIIB-DNA quaternary complex.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(20):10620-5.
1996: G Parkinson; A Gunasekera; J Vojtechovsky; X Zhang; T A Kunkel; H Berman; Richard H. Ebright
Aromatic hydrogen bond in sequence-specific protein DNA recognition.
Nature structural biology 1996;3(10):837-41.
1996: Tomasz Heyduk; Ewa Heyduk; Konstantin Severinov; H Tang; Richard H. Ebright
Determinants of RNA polymerase alpha subunit for interaction with beta, beta', and sigma subunits: hydroxyl-radical protein footprinting.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(19):10162-6.
1996: G Parkinson; C Wilson; A Gunasekera; Y W Ebright; R E Ebright; Richard H. Ebright; Helen M Berman
Structure of the CAP-DNA complex at 2.5 angstroms resolution: a complete picture of the protein-DNA interface.
Journal of molecular biology 1996;260(3):395-408.
1996: Y W Ebright; Y Chen; Y Kim; Richard H. Ebright
S-[2-(4-azidosalicylamido)ethylthio]-2-thiopyridine: radioiodinatable, cleavable, photoactivatible cross-linking agent.
Bioconjugate chemistry 1996;7(3):380-4.
1996: B Sheehan; A Klarsfeld; Richard H. Ebright; Pascale Cossart
A single substitution in the putative helix-turn-helix motif of the pleiotropic activator PrfA attenuates Listeria monocytogenes virulence.
Molecular microbiology 1996;20(4):785-97.
1996: P Dumoulin; Richard H. Ebright; R Knegtel; Robert Kaptein; M Granger-Schnarr; M Schnarr
Structure of the LexA repressor-DNA complex probed by affinity cleavage and affinity photo-cross-linking.
Biochemistry 1996;35(14):4279-86.
1996: H Tang; X Sun; D Reinberg; Richard H. Ebright
Protein-protein interactions in eukaryotic transcription initiation: structure of the preinitiation complex.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(3):1119-24.
1996: Tomasz Heyduk; Y Ma; H Tang; Richard H. Ebright
Fluorescence anisotropy: rapid, quantitative assay for protein-DNA and protein-protein interaction.
Methods in enzymology 1996;274():492-503.
1996: H Tang; Y Kim; Konstantin Severinov; A Goldfarb; Richard H. Ebright
Escherichia coli RNA polymerase holoenzyme: rapid reconstitution from recombinant alpha, beta, beta', and sigma subunits.
Methods in enzymology 1996;273():130-4.
1996: Tamas Gaal; Wilma Ross; E E Blatter; H Tang; X Jia; Viswanathan V Krishnan; Nuria Assa-Munt; Richard H. Ebright; Richard L Gourse
DNA-binding determinants of the alpha subunit of RNA polymerase: novel DNA-binding domain architecture.
Genes & development 1996;10(1):16-26.
1995: H Tang; Konstantin Severinov; A Goldfarb; Richard H. Ebright
Rapid RNA polymerase genetics: one-day, no-column preparation of reconstituted recombinant Escherichia coli RNA polymerase.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(11):4902-6.
1995: T J Merkel; J L Dahl; Richard H. Ebright; Robert J Kadner
Transcription activation at the Escherichia coli uhpT promoter by the catabolite gene activator protein.
Journal of bacteriology 1995;177(7):1712-8.
1995: Richard H. Ebright; S Busby
The Escherichia coli RNA polymerase alpha subunit: structure and function.
Current opinion in genetics & development 1995;5(2):197-203.
1994: H Tang; Konstantin Severinov; A Goldfarb; D Fenyo; Brian T Chait; Richard H. Ebright
Location, structure, and function of the target of a transcriptional activator protein.
Genes & development 1994;8(24):3058-67.
1994: Stephen Busby; Richard H. Ebright
Promoter structure, promoter recognition, and transcription activation in prokaryotes.
Cell 1994;79(5):743-6.
1994: Y Zhou; T J Merkel; Richard H. Ebright
Characterization of the activating region of Escherichia coli catabolite gene activator protein (CAP). II. Role at Class I and class II CAP-dependent promoters.
Journal of molecular biology 1994;243(4):603-10.
1994: W Niu; Y Zhou; Q Dong; Y W Ebright; Richard H. Ebright
Characterization of the activating region of Escherichia coli catabolite gene activator protein (CAP). I. Saturation and alanine-scanning mutagenesis.
Journal of molecular biology 1994;243(4):595-602.
1994: Y Zhou; P S Pendergrast; A Bell; R Williams; S Busby; Richard H. Ebright
The functional subunit of a dimeric transcription activator protein depends on promoter architecture.
The EMBO journal 1994;13(19):4549-57.
1994: E E Blatter; W Ross; H Tang; R L Gourse; Richard H. Ebright
Domain organization of RNA polymerase alpha subunit: C-terminal 85 amino acids constitute a domain capable of dimerization and DNA binding.
Cell 1994;78(5):889-96.
1994: P S Pendergrast; Y W Ebright; Richard H. Ebright
High-specificity DNA cleavage agent: design and application to kilobase and megabase DNA substrates.
Science (New York, N.Y.) 1994;265(5174):959-62.
1994: Y Chen; Y W Ebright; Richard H. Ebright
Identification of the target of a transcription activator protein by protein-protein photocrosslinking.
Science (New York, N.Y.) 1994;265(5168):90-2.
1994: Z Shang; Y W Ebright; Nancy Iler; P S Pendergrast; Yann Echelard; Andrew P McMahon; Richard H. Ebright; C Abate
DNA affinity cleaving analysis of homeodomain-DNA interaction: identification of homeodomain consensus sites in genomic DNA.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(1):118-22.
1994: Q Dong; E E Blatter; Y W Ebright; K Bister; Richard H. Ebright
Identification of amino acid-base contacts in the Myc-DNA complex by site-specific bromouracil mediated photocrosslinking.
The EMBO journal 1994;13(1):200-4.
1993: Tomasz Heyduk; J Ching Lee; Y W Ebright; E E Blatter; Y Zhou; Richard H. Ebright
CAP interacts with RNA polymerase in solution in the absence of promoter DNA.
Nature 1993;364(6437):548-9.
1993: Y Zhou; X Zhang; Richard H. Ebright
Identification of the activating region of catabolite gene activator protein (CAP): isolation and characterization of mutants of CAP specifically defective in transcription activation.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(13):6081-5.
1993: Richard H. Ebright
Transcription activation at Class I CAP-dependent promoters.
Molecular microbiology 1993;8(5):797-802.
1993: Y W Ebright; Y Chen; Richard D Ludescher; Richard H. Ebright
N-(iodoacetyl)-p-phenylenediamine-EDTA: a reagent for high-efficiency incorporation of an EDTA-metal complex at a rationally selected site within a protein.
Bioconjugate chemistry 1993;4(3):219-25.
1993: Y Zhou; S Busby; Richard H. Ebright
Identification of the functional subunit of a dimeric transcription activator protein by use of oriented heterodimers.
Cell 1993;73(2):375-9.
1993: Y Chen; Richard H. Ebright
Phenyl-azide-mediated photocrosslinking analysis of Cro-DNA interaction.
Journal of molecular biology 1993;230(2):453-60.
1992: Y W Ebright; Y Chen; P S Pendergrast; Richard H. Ebright
Incorporation of an EDTA-metal complex at a rationally selected site within a protein: application to EDTA-iron DNA affinity cleaving with catabolite gene activator protein (CAP) and Cro.
Biochemistry 1992;31(44):10664-70.
1992: P S Pendergrast; Y Chen; Y W Ebright; Richard H. Ebright
Determination of the orientation of a DNA binding motif in a protein-DNA complex by photocrosslinking.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(21):10287-91.
1992: E E Blatter; Y W Ebright; Richard H. Ebright
Identification of an amino acid-base contact in the GCN4-DNA complex by bromouracil-mediated photocrosslinking.
Nature 1992;359(6396):650-2.
1992: Q Dong; Richard H. Ebright
DNA binding specificity and sequence of Xanthomonas campestris catabolite gene activator protein-like protein.
Journal of bacteriology 1992;174(16):5457-61.
1992: A Gunasekera; Y W Ebright; Richard H. Ebright
DNA sequence determinants for binding of the Escherichia coli catabolite gene activator protein.
The Journal of biological chemistry 1992;267(21):14713-20.
1992: Richard H. Ebright; Q Dong; Joachim Messing
Corrected nucleotide sequence of M13mp18 gene III.
Gene 1992;114(1):81-3.
1992: X Zhang; Y Zhou; Y W Ebright; Richard H. Ebright
Catabolite gene activator protein (CAP) is not an "acidic activating region" transcription activator protein. Negatively charged amino acids of CAP that are solvent-accessible in the CAP-DNA complex play no role in transcription activation at the lac promoter.
The Journal of biological chemistry 1992;267(12):8136-9.
1991: X P Zhang; A Gunasekera; Y W Ebright; Richard H. Ebright
Derivatives of CAP having no solvent-accessible cysteine residues, or having a unique solvent-accessible cysteine residue at amino acid 2 of the helix-turn-helix motif.
Journal of biomolecular structure & dynamics 1991;9(3):463-73.
1991: Y H Zhou; X P Zhang; Richard H. Ebright
Random mutagenesis of gene-sized DNA molecules by use of PCR with Taq DNA polymerase.
Nucleic acids research 1991;19(21):6052.
1991: J A Shin; Richard H. Ebright; Peter B Dervan
Orientation of the Lac repressor DNA binding domain in complex with the left lac operator half site characterized by affinity cleaving.
Nucleic acids research 1991;19(19):5233-6.
1991: Richard H. Ebright
Identification of amino acid-base pair contacts by genetic methods.
Methods in enzymology 1991;208():620-40.
1990: A Gunasekera; Y W Ebright; Richard H. Ebright
DNA-sequence recognition by CAP: role of the adenine N6 atom of base pair 6 of the DNA site.
Nucleic acids research 1990;18(23):6853-6.
1990: X P Zhang; Richard H. Ebright
Substitution of 2 base pairs (1 base pair per DNA half-site) within the Escherichia coli lac promoter DNA site for catabolite gene activator protein places the lac promoter in the FNR regulon.
The Journal of biological chemistry 1990;265(21):12400-3.
1990: X P Zhang; Richard H. Ebright
Identification of a contact between arginine-180 of the catabolite gene activator protein (CAP) and base pair 5 of the DNA site in the CAP-DNA complex.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(12):4717-21.
1990: Richard H. Ebright; Y W Ebright; P S Pendergrast; A Gunasekera
Conversion of a helix-turn-helix motif sequence-specific DNA binding protein into a site-specific DNA cleavage agent.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(8):2882-6.
1990: Richard H. Ebright; A Gunasekera; X P Zhang; T A Kunkel; J S Krakow
Lysine 188 of the catabolite gene activator protein (CAP) plays no role in specificity at base pair 7 of the DNA half site.
Nucleic acids research 1990;18(6):1457-64.
1989: Richard H. Ebright; Y W Ebright; A Gunasekera
Consensus DNA site for the Escherichia coli catabolite gene activator protein (CAP): CAP exhibits a 450-fold higher affinity for the consensus DNA site than for the E. coli lac DNA site.
Nucleic acids research 1989;17(24):10295-305.
1987: Richard H. Ebright; A Kolb; H Buc; T A Kunkel; J S Krakow; Jonathan R. Beckwith
Role of glutamic acid-181 in DNA-sequence recognition by the catabolite gene activator protein (CAP) of Escherichia coli: altered DNA-sequence-recognition properties of [Val181]CAP and [Leu181]CAP.
Proceedings of the National Academy of Sciences of the United States of America 1987;84(17):6083-7.
1986: Richard H. Ebright; J R Wong; Lan Bo Chen
Binding of 2-hydroxybenzo(a)pyrene to estrogen receptors in rat cytosol.
Cancer research 1986;46(5):2349-51.
1986: Richard H. Ebright
Evidence for a contact between glutamine-18 of lac repressor and base pair 7 of lac operator.
Proceedings of the National Academy of Sciences of the United States of America 1986;83(2):303-7.
1985: Richard H. Ebright
Use of "loss-of-contact" substitutions to identify residues involved in an amino acid-base pair contact: effect of substitution of Gln18 of lac repressor by Gly, Ser, and Leu.
Journal of biomolecular structure & dynamics 1985;3(2):281-97.
1985: Richard H. Ebright; S F Le Grice; J P Miller; J S Krakow
Analogs of cyclic AMP that elicit the biochemically defined conformational change in catabolite gene activator protein (CAP) but do not stimulate binding to DNA.
Journal of molecular biology 1985;182(1):91-107.
1985: W L Duax; J F Griffin; Richard H. Ebright
Structural basis for chemotherapeutic action of antiestrogens.
Progress in clinical and biological research 1985;172B():263-73.
1985: Richard H. Ebright; Jonathan R. Beckwith
The catabolite gene activator protein (CAP) is not required for indole-3-acetic acid to activate transcription of the araBAD operon of Escherichia coli K-12.
Molecular & general genetics : MGG 1985;201(1):51-5.
1984: Richard H. Ebright; Pascale Cossart; B Gicquel-Sanzey; Jonathan R. Beckwith
Molecular basis of DNA sequence recognition by the catabolite gene activator protein: detailed inferences from three mutations that alter DNA sequence specificity.
Proceedings of the National Academy of Sciences of the United States of America 1984;81(23):7274-8.
1984: Richard H. Ebright; Pascale Cossart; B Gicquel-Sanzey; Jonathan R. Beckwith
Mutations that alter the DNA sequence specificity of the catabolite gene activator protein of E. coli.
Nature 1984;311(5983):232-5.
1981: Richard H. Ebright; J R Wong
Mechanism for transcriptional action of cyclic AMP in Escherichia coli: entry into DNA to disrupt DNA secondary structure.
Proceedings of the National Academy of Sciences of the United States of America 1981;78(7):4011-5.