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Donald Burns

Research Profile

Chemicals & Drugs

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Publications

TOP 3
John R Atack; D J Hallett; S Tye; Keith A Wafford; C Ryan; S M Sanabria-Bohórquez; Wai-Si Eng; R E Gibson; H Donald Burns; Gerard R Dawson; R W Carling; Leslie J Street; Andrew Pike; I De Lepeleire; K Van Laere; G Bormans; J N de Hoon; A Van Hecken; Ruth M McKernan; M G Murphy; Richard Hargreaves
Preclinical and clinical pharmacology of TPA023B, a GABAA receptor α2/α3 subtype-selective partial agonist.
W Eng; J R Atack; M Bergstrom; S Sanabria; L Appel; G R Dawson; D Sciberras; R J Hargreaves; B Langstrom; H Donald Burns
Occupancy of human brain GABA(A) receptors by the novel α5 subtype-selective benzodiazepine site inverse agonist α5IA as measured using [¹¹C]flumazenil PET imaging.
John R Atack; Karen A Maubach; Keith A Wafford; Desmond O'Connor; A David Rodrigues; David C Evans; F David Tattersall; Mark S Chambers; Angus M MacLeod; Wai-Si Eng; Christine Ryan; Eric Hostetler; Sandra M Sanabria; Raymond E Gibson; Stephen Krause; H Donald Burns; Richard J Hargreaves; Nancy G B Agrawal; Ruth M McKernan; M Gail Murphy; Kevin Gingrich; Gerard Dawson; Donald G Musson; Petty Kevin
In vitro and in vivo properties of 3-tert-butyl-7-(5-methylisoxazol-3-yl)-2-(1-methyl-1H-1,2,4-triazol-5-ylmethoxy)-pyrazolo[1,5-d]-[1,2,4]triazine (MRK-016), a GABAA receptor alpha5 subtype-selective inverse agonist.

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All Publications

2011: John R Atack; D J Hallett; S Tye; Keith A Wafford; C Ryan; S M Sanabria-Bohórquez; Wai-Si Eng; R E Gibson; H Donald Burns; Gerard R Dawson; R W Carling; Leslie J Street; Andrew Pike; I De Lepeleire; K Van Laere; G Bormans; J N de Hoon; A Van Hecken; Ruth M McKernan; M G Murphy; Richard Hargreaves
Preclinical and clinical pharmacology of TPA023B, a GABAA receptor α2/α3 subtype-selective partial agonist.
Journal of psychopharmacology (Oxford, England) 2011;25(3):329-44.
2010: W Eng; J R Atack; M Bergstrom; S Sanabria; L Appel; G R Dawson; D Sciberras; R J Hargreaves; B Langstrom; H Donald Burns
Occupancy of human brain GABA(A) receptors by the novel α5 subtype-selective benzodiazepine site inverse agonist α5IA as measured using [¹¹C]flumazenil PET imaging.
Neuropharmacology 2010;59(7-8):635-9.
2009: John R Atack; Karen A Maubach; Keith A Wafford; Desmond O'Connor; A David Rodrigues; David C Evans; F David Tattersall; Mark S Chambers; Angus M MacLeod; Wai-Si Eng; Christine Ryan; Eric Hostetler; Sandra M Sanabria; Raymond E Gibson; Stephen Krause; H Donald Burns; Richard J Hargreaves; Nancy G B Agrawal; Ruth M McKernan; M Gail Murphy; Kevin Gingrich; Gerard Dawson; Donald G Musson; Petty Kevin
In vitro and in vivo properties of 3-tert-butyl-7-(5-methylisoxazol-3-yl)-2-(1-methyl-1H-1,2,4-triazol-5-ylmethoxy)-pyrazolo[1,5-d]-[1,2,4]triazine (MRK-016), a GABAA receptor alpha5 subtype-selective inverse agonist.
The Journal of pharmacology and experimental therapeutics 2009;331(2):470-84.
2009: John R Atack; Wai-Si Eng; Ray E Gibson; Christine Ryan; Barbara Francis; Bindi Sohal; Gerard R Dawson; Richard Hargreaves; H Donald Burns
The plasma-occupancy relationship of the novel GABAA receptor benzodiazepine site ligand, alpha5IA, is similar in rats and primates.
British journal of pharmacology 2009;157(5):796-803.
2009: Yota Fujimura; Fumihiko Yasuno; Amanda Farris; Jeih-San Liow; Marilla Geraci; Wayne Drevets; Daniel S Pine; Subroto Ghose; Alicja Lerner; Richard Hargreaves; H Donald Burns; Cheryl Morse; Victor W Pike; Robert B Innis
Decreased neurokinin-1 (substance P) receptor binding in patients with panic disorder: positron emission tomographic study with [18F]SPA-RQ.
Biological psychiatry 2009;66(1):94-7.
2008: Koen Van Laere; Guy Bormans; Sandra Sanabria; Tjibbe de Groot; Patrick Dupont; Inge De Lepeleire; Jan de Hoon; Luc Mortelmans; Richard Hargreaves; John R Atack; H Donald Burns
In vivo characterization and dynamic receptor occupancy imaging of TPA023B, an alpha 2/alpha 3/alpha 5 subtype selective gamma-aminobutyric acid-a partial agonist.
Biological psychiatry 2008;64(2):153-61.
2008: Koen Van Laere; Michel Koole; Sandra M Sanabria Bohorquez; Karolien Goffin; Ilonka Guenther; Marie J Belanger; Josee Cote; Paul Rothenberg; Inge De Lepeleire; Igor D Grachev; Richard J Hargreaves; Guy Bormans; H Donald Burns
Whole-body biodistribution and radiation dosimetry of the human cannabinoid type-1 receptor ligand 18F-MK-9470 in healthy subjects.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2008;49(3):439-45.
2008: Carol Addy; Hamish Wright; Koen Van Laere; Ira Gantz; Ngozi Erondu; Bret J Musser; Kaifeng Lu; Jinyu Yuan; Sandra Sanabria; Aubrey Stoch; Cathy Stevens; Tung M Fong; Inge De Lepeleire; Caroline Cilissen; Josee Cote; Kim Rosko; Isaias N Gendrano; allison nguyen; Barry Gumbiner; Paul Rothenberg; Jan de Hoon; Guy Bormans; Marleen Depré; Wai-si Eng; Eric Ravussin; Samuel Klein; John Blundell; Gary A Herman; H Donald Burns; Richard J Hargreaves; John Wagner; Keith Gottesdiener; John M Amatruda; Steven B Heymsfield
The acyclic CB1R inverse agonist taranabant mediates weight loss by increasing energy expenditure and decreasing caloric intake.
Cell metabolism 2008;7(1):68-78.
1993: D Scott Wilbur; Donald K Hamlin; R R Srivastava; H Donald Burns
Synthesis and radioiodination of N-Boc-p-(tri-n-butylstannyl)-L-phenylalanine tetrafluorophenyl ester: preparation of a radiolabeled phenylalanine derivative for peptide synthesis.
Bioconjugate chemistry 1993;4(6):574-80.
1983: Tomás R Guilarte; H Donald Burns; Robert F Dannals; Henry N Wagner
A simple radiometric in vitro assay for acetylcholinesterase inhibitors.
Journal of pharmaceutical sciences 1983;72(1):90-2.
1982: R Vaum; N D Heindel; H Donald Burns; J Emrich; N Foster
Synthesis and evaluation of an 111In-labeled porphyrin for lymph node imaging.
Journal of pharmaceutical sciences 1982;71(11):1223-6.