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Andrea Cesura

Research Profile

Chemicals & Drugs

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Rats

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Amino Acid Sequences

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Eva Milanesi; Paola Costantini; Alberto Gambalunga; Raffaele Colonna; Valeria Petronilli; Anna Cabrelle; Gianpietro Semenzato; Andrea M Cesura; emmanuel pinard; Paolo Bernardi
The mitochondrial effects of small organic ligands of BCL-2: sensitization of BCL-2-overexpressing cells to apoptosis by a pyrimidine-2,4,6-trione derivative.
Daniel Schlatter; Ralf Thoma; Erich Küng; Martine Stihle; Francis Müller; Edilio Borroni; Andrea M Cesura; Michael Hennig
Crystal engineering yields crystals of cyclophilin D diffracting to 1.7 A resolution.
Andrea M Cesura; emmanuel pinard; Robert Schubenel; Valerie Goetschy; Arno Friedlein; Hanno Langen; Peter Polcic; Michael Forte; Paolo Bernardi; John A Kemp
The voltage-dependent anion channel is the target for a new class of inhibitors of the mitochondrial permeability transition pore.

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All Publications

2006: Eva Milanesi; Paola Costantini; Alberto Gambalunga; Raffaele Colonna; Valeria Petronilli; Anna Cabrelle; Gianpietro Semenzato; Andrea M Cesura; emmanuel pinard; Paolo Bernardi
The mitochondrial effects of small organic ligands of BCL-2: sensitization of BCL-2-overexpressing cells to apoptosis by a pyrimidine-2,4,6-trione derivative.
The Journal of biological chemistry 2006;281(15):10066-72.
2005: Daniel Schlatter; Ralf Thoma; Erich Küng; Martine Stihle; Francis Müller; Edilio Borroni; Andrea M Cesura; Michael Hennig
Crystal engineering yields crystals of cyclophilin D diffracting to 1.7 A resolution.
Acta crystallographica. Section D, Biological crystallography 2005;61(Pt 5):513-9.
2003: Andrea M Cesura; emmanuel pinard; Robert Schubenel; Valerie Goetschy; Arno Friedlein; Hanno Langen; Peter Polcic; Michael Forte; Paolo Bernardi; John A Kemp
The voltage-dependent anion channel is the target for a new class of inhibitors of the mitochondrial permeability transition pore.
The Journal of biological chemistry 2003;278(50):49812-8.
2003: Sabine Kolczewski; Geo Adam; Andrea M Cesura; François Jenck; Michael Hennig; Thomas Oberhauser; Sonia Poli; Felix Rössler; Stephan Röver; Jürgen Wichmann; Frank M Dautzenberg
Novel hexahydrospiro[piperidine-4,1'-pyrrolo[3,4-c]pyrroles]: highly selective small-molecule nociceptin/orphanin FQ receptor agonists.
Journal of medicinal chemistry 2003;46(2):255-64.
2001: Edilio Borroni; Andrea M Cesura; S Gatti; R Gasser
A preclinical re-evaluation of the safety profile of tolcapone.
Functional neurology 2001;16(4 Suppl):125-34.
2000: Jürgen Wichmann; Geo Adam; Stephan Röver; Michael Hennig; M Scalone; Andrea M Cesura; Frank M Dautzenberg; François Jenck
Synthesis of (1S,3aS)-8-(2,3,3a,4,5, 6-hexahydro-1H-phenalen-1-yl)-1-phenyl-1,3,8-triaza-spiro[4. 5]decan-4-one, a potent and selective orphanin FQ (OFQ) receptor agonist with anxiolytic-like properties.
European journal of medicinal chemistry 2000;35(9):839-51.
2000: François Jenck; Jürgen Wichmann; Frank M Dautzenberg; Jean-Luc Moreau; Abdel-Mouttalib Ouagazzal; James R Martin; Kenneth Lundstrom; Andrea M Cesura; Sonia Poli; S Roever; Sabine Kolczewski; Geo Adam; GJ Kilpatrick
A synthetic agonist at the orphanin FQ/nociceptin receptor ORL1: anxiolytic profile in the rat.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(9):4938-43.
2000: Stephan Röver; Jürgen Wichmann; François Jenck; Geo Adam; Andrea M Cesura
ORL1 receptor ligands: structure-activity relationships of 8-cycloalkyl-1-phenyl-1,3,8-triaza-spiro[4.5]decan-4-ones.
Bioorganic & medicinal chemistry letters 2000;10(8):831-4.
2000: Stephan Röver; Geo Adam; Andrea M Cesura; G Galley; François Jenck; FJ Monsma; Jürgen Wichmann; Frank M Dautzenberg
High-affinity, non-peptide agonists for the ORL1 (orphanin FQ/nociceptin) receptor.
Journal of medicinal chemistry 2000;43(7):1329-38.
1999: Jürgen Wichmann; Geo Adam; Stephan Röver; Andrea M Cesura; Frank M Dautzenberg; François Jenck
8-acenaphthen-1-yl-1-phenyl-1,3,8-triaza-spiro[4.5]decan-4-one derivatives as orphanin FQ receptor agonists.
Bioorganic & medicinal chemistry letters 1999;9(16):2343-8.
1999: Andrea M Cesura; Edilio Borroni; J Gottowik; C Kuhn; Pari Malherbe; J Martin; J Grayson Richards
Lazabemide for the treatment of Alzheimer's disease: rationale and therapeutic perspectives.
Advances in neurology 1999;80():521-8.
1998: D Alberati-Giani; Andrea M Cesura
Expression of the kynurenine enzymes in macrophages and microglial cells: regulation by immune modulators.
Amino acids 1998;14(1-3):251-5.
1998: Andrea M Cesura; J Gottowik; G Lang; Pari Malherbe; M Da Prada
Structure-function relationships of mitochondrial monoamine oxidase A and B: chimaeric enzymes and site-directed mutagenesis studies.
Journal of neural transmission. Supplementum 1998;52():189-200.
1998: J Grayson Richards; J Saura; J M Luque; Andrea M Cesura; J Gottowik; Pari Malherbe; Edilio Borroni; J Gray
Monoamine oxidases: from brain maps to physiology and transgenics to pathophysiology.
Journal of neural transmission. Supplementum 1998;52():173-87.
1997: Stephan Röver; Andrea M Cesura; P Huguenin; R Kettler; A Szente
Synthesis and biochemical evaluation of N-(4-phenylthiazol-2-yl)benzenesulfonamides as high-affinity inhibitors of kynurenine 3-hydroxylase.
Journal of medicinal chemistry 1997;40(26):4378-85.
1997: D Alberati-Giani; Pari Malherbe; Paola Ricciardi-Castagnoli; C Köhler; Suzanne Denis-Donini; Andrea M Cesura
Differential regulation of indoleamine 2,3-dioxygenase expression by nitric oxide and inflammatory mediators in IFN-gamma-activated murine macrophages and microglial cells.
Journal of immunology (Baltimore, Md. : 1950) 1997;159(1):419-26.
1997: D Alberati-Giani; Andrea M Cesura; Clemens Broger; W D Warren; Stephan Röver; Pari Malherbe
Cloning and functional expression of human kynurenine 3-monooxygenase.
FEBS letters 1997;410(2-3):407-12.
1996: D Alberati-Giani; R Buchli; Pari Malherbe; C Broger; G Lang; C Köhler; H W Lahm; Andrea M Cesura
Isolation and expression of a cDNA clone encoding human kynureninase.
European journal of biochemistry / FEBS 1996;239(2):460-8.
1996: Andrea M Cesura; J Gottowik; H W Lahm; G Lang; R Imhof; Pari Malherbe; U Röthlisberger; M Da Prada
Investigation on the structure of the active site of monoamine oxidase-B by affinity labeling with the selective inhibitor lazabemide and by site-directed mutagenesis.
European journal of biochemistry / FEBS 1996;236(3):996-1002.
1996: D Alberati-Giani; Paola Ricciardi-Castagnoli; C Köhler; Andrea M Cesura
Regulation of the kynurenine metabolic pathway by interferon-gamma in murine cloned macrophages and microglial cells.
Journal of neurochemistry 1996;66(3):996-1004.
1996: Andrea M Cesura; D Alberati-Giani; R Buchli; C Broger; C Köhler; FRancis VILBOIS; H W Lahm; Marie-Paule Heitz; Pari Malherbe
Molecular characterisation of kynurenine pathway enzymes. 3-Hydroxyanthranilic-acid dioxygenase and kynurenine aminotransferase.
Advances in experimental medicine and biology 1996;398():477-83.
1996: D Alberati-Giani; Paola Ricciardi-Castagnoli; C Köhler; Andrea M Cesura
Regulation of the kynurenine pathway by IFN-gamma in murine cloned macrophages and microglial cells.
Advances in experimental medicine and biology 1996;398():171-5.
1995: R Buchli; D Alberati-Giani; Pari Malherbe; C Köhler; C Broger; Andrea M Cesura
Cloning and functional expression of a soluble form of kynurenine/alpha-aminoadipate aminotransferase from rat kidney.
The Journal of biological chemistry 1995;270(49):29330-5.
1995: Pari Malherbe; D Alberati-Giani; C Köhler; Andrea M Cesura
Identification of a mitochondrial form of kynurenine aminotransferase/glutamine transaminase K from rat brain.
FEBS letters 1995;367(2):141-4.
1995: J Gottowik; Pari Malherbe; G Lang; M Da Prada; Andrea M Cesura
Structure/function relationships of mitochondrial monoamine oxidase A and B chimeric forms.
European journal of biochemistry / FEBS 1995;230(3):934-42.
1995: D Alberati-Giani; Pari Malherbe; C Köhler; G Lang; V Kiefer; H W Lahm; Andrea M Cesura
Cloning and characterization of a soluble kynurenine aminotransferase from rat brain: identity with kidney cysteine conjugate beta-lyase.
Journal of neurochemistry 1995;64(4):1448-55.
1995: A Napolitano; Andrea M Cesura; M Da Prada
The role of monoamine oxidase and catechol O-methyltransferase in dopaminergic neurotransmission.
Journal of neural transmission. Supplementum 1995;45():35-45.
1994: J Saura; J M Luque; Andrea M Cesura; M Da Prada; V Chan-Palay; G Huber; J Löffler; J Grayson Richards
Increased monoamine oxidase B activity in plaque-associated astrocytes of Alzheimer brains revealed by quantitative enzyme radioautography.
Neuroscience 1994;62(1):15-30.
1994: FRancis VILBOIS; P Caspers; M da Prada; G Lang; C Karrer; H W Lahm; Andrea M Cesura
Mass spectrometric analysis of human soluble catechol O-methyltransferase expressed in Escherichia coli. Identification of a product of ribosomal frameshifting and of reactive cysteines involved in S-adenosyl-L-methionine binding.
European journal of biochemistry / FEBS 1994;222(2):377-86.
1994: J M Luque; R Erat; R Kettler; Andrea M Cesura; M Da Prada; J Grayson Richards
Radioautographic evidence that the GABAA receptor antagonist SR 95531 is a substrate inhibitor of MAO-A in the rat and human locus coeruleus.
The European journal of neuroscience 1994;6(6):1038-49.
1994: Pari Malherbe; C Köhler; M Da Prada; G Lang; V Kiefer; Robert Schwarcz; H W Lahm; Andrea M Cesura
Molecular cloning and functional expression of human 3-hydroxyanthranilic-acid dioxygenase.
The Journal of biological chemistry 1994;269(19):13792-7.
1993: A Colzi; F D'Agostini; Andrea M Cesura; Edilio Borroni; M Da Prada
Monoamine oxidase-A inhibitors and dopamine metabolism in rat caudatus: evidence that an increased cytosolic level of dopamine displaces reversible monoamine oxidase-A inhibitors in vivo.
The Journal of pharmacology and experimental therapeutics 1993;265(1):103-11.
1993: J Gottowik; Andrea M Cesura; Pari Malherbe; G Lang; M Da Prada
Characterisation of wild-type and mutant forms of human monoamine oxidase A and B expressed in a mammalian cell line.
FEBS letters 1993;317(1-2):152-6.
1993: W Haefely; W P Burkard; Andrea M Cesura; A Colzi; R Kettler; H P Lorez; James R Martin; Jean-Luc Moreau; J Grayson Richards; R Schaffner
Pharmacology of moclobemide.
Clinical neuropharmacology 1993;16 Suppl 2():S8-18.
1992: Andrea M Cesura; A Pletscher
The new generation of monoamine oxidase inhibitors.
Progress in drug research. Fortschritte der Arzneimittelforschung. Progrès des recherches pharmaceutiques 1992;38():171-297.
1992: W Haefely; W P Burkard; Andrea M Cesura; R Kettler; H P Lorez; James R Martin; J Grayson Richards; R Scherschlicht; M Da Prada
Biochemistry and pharmacology of moclobemide, a prototype RIMA.
Psychopharmacology 1992;106 Suppl():S6-14.
1992: A Colzi; F d'Agostini; Andrea M Cesura; M Da Prada
Brain microdialysis in rats: a technique to reveal competition in vivo between endogenous dopamine and moclobemide, a RIMA antidepressant.
Psychopharmacology 1992;106 Suppl():S17-20.
1992: Andrea M Cesura; R Kettler; R Imhof; M Da Prada
Mode of action and characteristics of monoamine oxidase-A inhibition by moclobemide.
Psychopharmacology 1992;106 Suppl():S15-6.
1990: Andrea M Cesura; B Bertocci; M Da Prada
Binding of [3H]dihydrotetrabenazine and [125I]azidoiodoketanserin photoaffinity labeling of the monoamine transporter of platelet 5-HT organelles.
European journal of pharmacology 1990;186(1):95-104.
1990: Andrea M Cesura; M Bös; M D Galva; R Imhof; M Da Prada
Characterization of the binding of [3H]Ro 41-1049 to the active site of human monoamine oxidase-A.
Molecular pharmacology 1990;37(3):358-66.
1990: Andrea M Cesura; R Imhof; D Muggli-Maniglio; G B Picotti; M Da Prada
Characterization of [3H]Ro 16-6491 binding to digitonin solubilized monoamine oxidase-B and purification of the enzyme from human platelets by affinity chromatography.
Biochemical pharmacology 1990;39(1):216-20.
1990: M Da Prada; R Kettler; H H Keller; Andrea M Cesura; J Grayson Richards; J Saura Marti; D Muggli-Maniglio; P C Wyss; E Kyburz; R Imhof
From moclobemide to Ro 19-6327 and Ro 41-1049: the development of a new class of reversible, selective MAO-A and MAO-B inhibitors.
Journal of neural transmission. Supplementum 1990;29():279-92.
1990: R Kettler; Andrea M Cesura; J Dingemanse; M Da Prada
MAO-B inhibition in rabbit tissues and in human platelets by Ro 19-6327 shows similar time-course.
Journal of neural transmission. Supplementum 1990;32():211-4.
1990: Andrea M Cesura; D Muggli-Maniglio; G Lang; R Imhof; M Da Prada
Monoamine oxidase inhibition by moclobemide and 2-amino-ethyl carboxamide derivatives: mode of action and kinetic characteristics.
Journal of neural transmission. Supplementum 1990;32():165-70.
1989: Andrea M Cesura; M D Galva; R Imhof; E Kyburz; G B Picotti; M Da Prada
[3H]Ro 19-6327: a reversible ligand and affinity labelling probe for monoamine oxidase-B.
European journal of pharmacology 1989;162(3):457-65.
1988: Andrea M Cesura; R Imhof; M D Galva; R Kettler; M Da Prada
Interactions of the novel inhibitors of MAO-B Ro 19-6327 and Ro 16-6491 with the active site of the enzyme.
Pharmacological research communications 1988;20 Suppl 4():51-61.
1988: M Da Prada; R Kettler; Andrea M Cesura; J G Richards
Reversible, enzyme-activated monoamine oxidase inhibitors: new advances.
Pharmacological research communications 1988;20 Suppl 4():21-33.
1988: Andrea M Cesura; R Imhof; B Takacs; M D Galva; G B Picotti; M Da Prada
[3H]Ro 16-6491, a selective probe for affinity labelling of monoamine oxidase type B in human brain and platelet membranes.
Journal of neurochemistry 1988;50(4):1037-43.
1988: M Da Prada; Andrea M Cesura; J M Launay; J Grayson Richards
Platelets as a model for neurones?
Experientia 1988;44(2):115-26.
1988: Marcello Giovannini; R Valsasina; R Longhi; Andrea M Cesura; M D Galva; Enrica Riva; G P Bondiolotti; G B Picotti
Serotonin and noradrenaline concentrations and serotonin uptake in platelets from hyperphenylalaninaemic patients.
Journal of inherited metabolic disease 1988;11(3):285-90.
1987: Andrea M Cesura; A Ritter; G B Picotti; M Da Prada
Uptake, release, and subcellular localization of 1-methyl-4-phenylpyridinium in blood platelets.
Journal of neurochemistry 1987;49(1):138-45.
1987: Andrea M Cesura; M D Galva; R Imhof; M Da Prada
Binding of [3H]Ro 16-6491, a reversible inhibitor of monoamine oxidase type B, to human brain mitochondria and platelet membranes.
Journal of neurochemistry 1987;48(1):170-6.
1985: M Da Prada; Andrea M Cesura; R Kettler; G Zürcher; W E Haefely
Conversion of the neurotoxic precursor 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine into its pyridinium metabolite by human platelet monoamine oxidase type B.
Neuroscience letters 1985;57(3):257-62.
1984: G B Picotti; G P Bondiolotti; Andrea M Cesura; C Ravazzani; M D Galva; P Mantegazza
Free (unconjugated) catecholamine concentrations in platelets: biological significance and clinical implications.
Advances in experimental medicine and biology 1984;164():257-68.
1983: Andrea M Cesura; K Müller; M Peyer; A Pletscher
Solubilization of imipramine-binding protein from human blood platelets.
European journal of pharmacology 1983;96(3-4):235-42.
1981: G B Picotti; M O Carruba; C Ravazzani; Andrea M Cesura; M D Galva; M Da Prada
Plasma catecholamines in rats exposed to cold: effects of ganglionic and adrenoreceptor blockade.
European journal of pharmacology 1981;69(3):321-9.