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Irina Gaisina

Research Profile

Chemicals & Drugs

Concepts & Ideas

Anatomy

Tumor Cell Line

Disorders

Bipolar Disorder

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Drug Design

Procedures

Drug Screening Assays, Antitumor

Physiology

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Publications

TOP 3
N A Smirnova; R E Speer; Irina N Gaisina; Dmitri M Hushpulian; Rajiv R Ratan; Irina Gazaryan
Catalytic mechanism and substrate specificity of HIF prolyl hydroxylases.
Tyvette S Hilliard; Amanda G Muehlbauer; Arsen M Gaisin; Irina N Gaisina; Franck Gallier; Joanna E Burdette
Glycogen synthase kinase 3β inhibitors induce apoptosis in ovarian cancer cells and inhibit in-vivo tumor growth.
Wenwen Chen; Irina N Gaisina; Hendra Gunosewoyo; Taleen Hanania; Sam A Malekiani; Alan P Kozikowski
Structure-guided design of a highly selective glycogen synthase kinase-3β inhibitor: a superior neuroprotective pyrazolone showing antimania effects.

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All Publications

2012: N A Smirnova; R E Speer; Irina N Gaisina; Dmitri M Hushpulian; Rajiv R Ratan; Irina Gazaryan
Catalytic mechanism and substrate specificity of HIF prolyl hydroxylases.
Biochemistry. Biokhimii͡a 2012;77(10):1108-19.
2011: Tyvette S Hilliard; Amanda G Muehlbauer; Arsen M Gaisin; Irina N Gaisina; Franck Gallier; Joanna E Burdette
Glycogen synthase kinase 3β inhibitors induce apoptosis in ovarian cancer cells and inhibit in-vivo tumor growth.
Anti-cancer drugs 2011;22(10):978-85.
2011: Wenwen Chen; Irina N Gaisina; Hendra Gunosewoyo; Taleen Hanania; Sam A Malekiani; Alan P Kozikowski
Structure-guided design of a highly selective glycogen synthase kinase-3β inhibitor: a superior neuroprotective pyrazolone showing antimania effects.
ChemMedChem 2011;6(9):1587-92.
2011: Alan P Kozikowski; Colleen A McClung; Andrew D Mesecar; Richard L Walter; Irina N Gaisina; Hendra Gunosewoyo; Songpo Guo; Ariel Ketcherside; Barbara Caldarone
Identification of a glycogen synthase kinase-3β inhibitor that attenuates hyperactivity in CLOCK mutant mice.
ChemMedChem 2011;6(9):1593-602.
2011: L Chen; W Zhou; P C Chen; Irina N Gaisina; S Yang; X Li
Glycogen synthase kinase-3β is a functional modulator of serotonin-1B receptors.
Molecular pharmacology 2011;79(6):974-86.
2010: Natalya A Smirnova; Ilay Rakhman; Natalia Moroz; Manuela Basso; Jimmy Payappilly; Sergey Kazakov; Francisco Hernandez-Guzman; Irina N Gaisina; Alan P Kozikowski; Rajiv R Ratan; Irina Gazaryan
Utilization of an in vivo reporter for high throughput identification of branched small molecule regulators of hypoxic adaptation.
Chemistry & biology 2010;17(4):380-91.
2009: Ki Hwan Kim; Irina N Gaisina; Franck Gallier; Denise Holzle; Sylvie Blond; Andrew D Mesecar; Alan P Kozikowski
Use of molecular modeling, docking, and 3D-QSAR studies for the determination of the binding mode of benzofuran-3-yl-(indol-3-yl)maleimides as GSK-3beta inhibitors.
Journal of molecular modeling 2009;15(12):1463-79.
2009: Irina N Gaisina; Franck Gallier; Andrei V Ougolkov; Ki H Kim; Toru Kurome; Songpo Guo; Denise Holzle; Doris N Luchini; Sylvie Blond; Daniel D Billadeau; Alan P Kozikowski
From a natural product lead to the identification of potent and selective benzofuran-3-yl-(indol-3-yl)maleimides as glycogen synthase kinase 3beta inhibitors that suppress proliferation and survival of pancreatic cancer cells.
Journal of medicinal chemistry 2009;52(7):1853-63.
2009: Nichole E LaPointe; Gerardo Morfini; Gustavo Pigino; Irina N Gaisina; Alan P Kozikowski; Lester I Binder; Scott T Brady
The amino terminus of tau inhibits kinesin-dependent axonal transport: implications for filament toxicity.
Journal of neuroscience research 2009;87(2):440-51.
2007: Alan P Kozikowski; Irina N Gaisina; Hongbin Yuan; Pavel A Petukhov; Sylvie Blond; Allison Fedolak; Barbara Caldarone; Paul McGonigle
Structure-based design leads to the identification of lithium mimetics that block mania-like effects in rodents. possible new GSK-3beta therapies for bipolar disorders.
Journal of the American Chemical Society 2007;129(26):8328-32.
2006: Alan P Kozikowski; Irina N Gaisina; Pavel A Petukhov; Jayalakshmi Sridhar; LaShaunda T King; Sylvie Blond; Tetyana Duka; Milan Rusnak; Anita Sidhu
Highly potent and specific GSK-3beta inhibitors that block tau phosphorylation and decrease alpha-synuclein protein expression in a cellular model of Parkinson's disease.
ChemMedChem 2006;1(2):256-66.