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Rob Willems

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Fernanda L Paganelli; Rob Willems; Xinglin Zhang; Marc J M Bonten; Antoni Hendrickx; Pamela Jansen; Helen L Leavis
Enterococcus faecium Biofilm Formation: Identification of Major Autolysin AtlAEfm, Associated Acm Surface Localization, and AtlAEfm-Independent Extracellular DNA Release.
Xinglin Zhang; Rob Willems; Damien Bierschenk; Marc J M Bonten; Annemarie Kuipers; Fernanda L Paganelli; Willem van Schaik
Genome-wide identification of ampicillin resistance determinants in Enterococcus faecium.
Patricia Ruiz-Garbajosa; H J M Harmsen; F Baquero; Marc J M Bonten; Rafael Cantón; Teresa M Coque; M de Regt; Rob Willems
High-density fecal Enterococcus faecium colonization in hospitalized patients is associated with the presence of the polyclonal subcluster CC17.

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2013: Fernanda L Paganelli; Rob Willems; Xinglin Zhang; Marc J M Bonten; Antoni Hendrickx; Pamela Jansen; Helen L Leavis
Enterococcus faecium Biofilm Formation: Identification of Major Autolysin AtlAEfm, Associated Acm Surface Localization, and AtlAEfm-Independent Extracellular DNA Release.
mBio 2013;4(2):.
2012: Xinglin Zhang; Rob Willems; Damien Bierschenk; Marc J M Bonten; Annemarie Kuipers; Fernanda L Paganelli; Willem van Schaik
Genome-wide identification of ampicillin resistance determinants in Enterococcus faecium.
PLoS genetics 2012;8(6):e1002804.
2012: Patricia Ruiz-Garbajosa; H J M Harmsen; F Baquero; Marc J M Bonten; Rafael Cantón; Teresa M Coque; M de Regt; Rob Willems
High-density fecal Enterococcus faecium colonization in hospitalized patients is associated with the presence of the polyclonal subcluster CC17.
European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology 2012;31(4):519-22.
2012: Alicja Kuch; Patricia Ruiz-Garbajosa; Teresa M Coque; Anette M Hammerum; Waleria Hryniewicz; Ingo Klare; Gunnar S Simonsen; Arnfinn Sundsfjord; Miranda van Luit-Asbroek; Guido Werner; Rob Willems; Ewa Sadowy
Insight into antimicrobial susceptibility and population structure of contemporary human Enterococcus faecalis isolates from Europe.
The Journal of antimicrobial chemotherapy 2012;67(3):551-8.
2012: Marc J M Bonten; Rob Willems
[Vancomycin-resistant enterococcus--chronicle of a foretold problem].
Nederlands tijdschrift voor geneeskunde 2012;156(38):A5233.
2012: François Lebreton; Roland Leclercq; Brunella Posteraro; maurizio Sanguinetti; Riccardo Torelli; Willem van Schaik; Nicolas Verneuil; Rob Willems; Xinglin Zhang; Anne Dhalluin; Jean-Christophe Giard; Florian Le Bras; Vincent Cattoir
AsrR is an oxidative stress sensing regulator modulating Enterococcus faecium opportunistic traits, antimicrobial resistance, and pathogenicity.
PLoS pathogens 2012;8(8):e1002834.
2012: Rob Willems; Marc Bonten; William P Hanage; Helen L Leavis; Jukka Sirén; Janetta Top; Willem van Schaik; Jukka Corander
Restricted gene flow among hospital subpopulations of Enterococcus faecium.
mBio 2012;3(4):e00151-12.
2012: Maja Weisser; Andreas F Widmer; Rob Willems; Marc J M Bonten; Luigia Elzi; Reno Frei; Jörg Halter; Evelien A Oostdijk; Janetta Top
Dynamics of ampicillin-resistant Enterococcus faecium clones colonizing hospitalized patients: data from a prospective observational study.
BMC infectious diseases 2012;12():68.
2012: Marieke J A de Regt; Huberta A T Dekker; Catherina J M Koning; Engeline van Duijkeren; Miranda van Luit-Asbroek; Willem van Schaik; Marc J M Bonten; Rob Willems
Hospital and community ampicillin-resistant Enterococcus faecium are evolutionarily closely linked but have diversified through niche adaptation.
PloS one 2012;7(2):e30319.
2012: Fernanda L Paganelli; Rob Willems; Helen L Leavis
Optimizing future treatment of enterococcal infections: attacking the biofilm?
Trends in microbiology 2012;20(1):40-9.
2011: Esther Heikens; Karen D Jacques-Palaz; Barbara E Murray; Evelien A N Oostdijk; Kavindra V Singh; Miranda van Luit-Asbroek; Marc J M Bonten; Rob Willems
Contribution of the enterococcal surface protein Esp to pathogenesis of Enterococcus faecium endocarditis.
Microbes and infection / Institut Pasteur 2011;13(14-15):1185-90.
2011: N Carpaij; M J M Bonten; Rob Willems; A C Fluit
Comparison of the identification of coagulase-negative staphylococci by matrix-assisted laser desorption ionization time-of-flight mass spectrometry and tuf sequencing.
European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology 2011;30(10):1169-72.
2011: Rob Willems; William P Hanage; Debra E Bessen; Edward J Feil
Population biology of Gram-positive pathogens: high-risk clones for dissemination of antibiotic resistance.
FEMS microbiology reviews 2011;35(5):872-900.
2011: A M M de Vrankrijker; R K Stellato; F T van Berkhout; Cornelis K van der Ent; Rob Willems; M J M Bonten; T F W Wolfs
Aspergillus fumigatus colonization in cystic fibrosis: implications for lung function?
Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases 2011;17(9):1381-6.
2011: María García-Castillo; María-Isabel Morosini; Antonio Oliver; Elena Riera; Rosa van Mansfeld; Rob Willems; Gabriel Cabot; Rosa del Campo; Rafael Cantón
Wide dispersion of ST175 clone despite high genetic diversity of carbapenem-nonsusceptible Pseudomonas aeruginosa clinical strains in 16 Spanish hospitals.
Journal of clinical microbiology 2011;49(8):2905-10.
2011: Babette C van Hees; Rob Willems; Douwe Biesma; Ben de Jong; Matthijs Tersmette; Erik J van Hannen
Molecular analysis of ciprofloxacin resistance and clonal relatedness of clinical Escherichia coli isolates from haematology patients receiving ciprofloxacin prophylaxis.
The Journal of antimicrobial chemotherapy 2011;66(8):1739-44.
2011: A K Van der Bij; R Van Mansfeld; G Peirano; W H F Goessens; J A Severin; J D D Pitout; Rob Willems; M Van Westreenen
First outbreak of VIM-2 metallo-β-lactamase-producing Pseudomonas aeruginosa in The Netherlands: microbiology, epidemiology and clinical outcomes.
International journal of antimicrobial agents 2011;37(6):513-8.
2011: J H T Wagenvoort; E I G B De Brauwer; R J R Penders; Rob Willems; J Top; M J Bonten
Environmental survival of vancomycin-resistant Enterococcus faecium.
The Journal of hospital infection 2011;77(3):282-3.
2011: A M M de Vrankrijker; R W Brimicombe; T F W Wolfs; H G M Heijerman; R van Mansfeld; F T van Berkhout; Rob Willems; M J M Bonten; C K van der Ent
Clinical impact of a highly prevalent Pseudomonas aeruginosa clone in Dutch cystic fibrosis patients.
Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases 2011;17(3):382-5.
2011: Janetta Top; Jan C Sinnige; Eline A M Majoor; Marc J M Bonten; Rob Willems; Willem van Schaik
The recombinase IntA is required for excision of esp-containing ICEEfm1 in Enterococcus faecium.
Journal of bacteriology 2011;193(4):1003-6.
2011: Guido Werner; Ana R Freitas; Teresa M Coque; Johanna E Sollid; Camilla Lester; Anette M Hammerum; Lourdes Garcia-Migura; Lars Bogø Jensen; Maria V Francia; Wolfgang Witte; Rob Willems; Arnfinn Sundsfjord
Host range of enterococcal vanA plasmids among Gram-positive intestinal bacteria.
The Journal of antimicrobial chemotherapy 2011;66(2):273-82.
2011: Xinglin Zhang; Joyce E P Vrijenhoek; Marc J M Bonten; Rob Willems; Willem van Schaik
A genetic element present on megaplasmids allows Enterococcus faecium to use raffinose as carbon source.
Environmental microbiology 2011;13(2):518-28.
2011: Sanne van den Berg; Willem J B Van Wamel; Henri A Verbrugh; Frank A W Verreck; Rob Willems; Hélène A M Boelens; Corné P de Vogel; Peter J Heidt; Xander W Huijsdens; Ivanela Kondova; Boudewijn Ouwerling; Susan Snijders; Alex Van Belkum
Rhesus macaques (Macaca mulatta) are natural hosts of specific Staphylococcus aureus lineages.
PloS one 2011;6(10):e26170.
2011: Jenny A Laverde Gomez; Antoni P A Hendrickx; Rob Willems; Janetta Top; Irina Sava; Johannes Huebner; Wolfgang Witte; Guido Werner
Intra- and interspecies genomic transfer of the Enterococcus faecalis pathogenicity island.
PloS one 2011;6(4):e16720.
2011: Neeltje Carpaij; Rob Willems; Thomas W Rice; Robert A Weinstein; Jason Hinds; Adam A Witney; Jodi Lindsay; Marc J M Bonten; Ad C Fluit
Genetic variation in spatio-temporal confined USA300 community-associated MRSA isolates: a shift from clonal dispersion to genetic evolution?
PloS one 2011;6(2):e16419.
2011: Margrete Solheim; Mari C Brekke; Lars G Snipen; Rob Willems; Ingolf F Nes; Dag A Brede
Comparative genomic analysis reveals significant enrichment of mobile genetic elements and genes encoding surface structure-proteins in hospital-associated clonal complex 2 Enterococcus faecalis.
BMC microbiology 2011;11():3.
2010: Eva Katrin Bjørkeng; Girum Tadesse Tessema; Eirik W Lundblad; Patrick Butaye; Rob Willems; Johanna Ericsson Sollid; Arnfinn Sundsfjord; Kristin Hegstad
ccrABEnt serine recombinase genes are widely distributed in the Enterococcus faecium and Enterococcus casseliflavus species groups and are expressed in E. faecium.
Microbiology (Reading, England) 2010;156(Pt 12):3624-34.
2010: Antoni P A Hendrickx; Claudia M E Schapendonk; Miranda van Luit-Asbroek; Marc J M Bonten; Willem van Schaik; Rob Willems
Differential PilA pilus assembly by a hospital-acquired and a community-derived Enterococcus faecium isolate.
Microbiology (Reading, England) 2010;156(Pt 9):2649-59.
2010: I G Sava; E Heikens; Andrea Kropec; Christian Theilacker; Rob Willems; johannes huebner
Enterococcal surface protein contributes to persistence in the host but is not a target of opsonic and protective antibodies in Enterococcus faecium infection.
Journal of medical microbiology 2010;59(Pt 9):1001-4.
2010: Danielle A Garsin; Rob Willems
Insights into the biofilm lifestyle of enterococci.
Virulence 2010;1(4):219-21.
2010: Marieke J A de Regt; Rob Willems; Ronald J Hené; Peter D Siersema; Harald J J Verhaar; T E M Hopmans; Marc J M Bonten
Effects of probiotics on acquisition and spread of multiresistant enterococci.
Antimicrobial agents and chemotherapy 2010;54(7):2801-5.
2010: W van Schaik; Rob Willems
Genome-based insights into the evolution of enterococci.
Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases 2010;16(6):527-32.
2010: Arnfinn Sundsfjord; Rob Willems
Enterococcus research: recent developments and clinical challenges.
Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases 2010;16(6):525-6.
2010: Saskia Nijssen; Ad Fluit; David van de Vijver; Janetta Top; Rob Willems; Marc J M Bonten
Effects of reducing beta-lactam antibiotic pressure on intestinal colonization of antibiotic-resistant gram-negative bacteria.
Intensive care medicine 2010;36(3):512-9.
2010: Masja Leendertse; Rob Willems; Roelof Flierman; Alex F de Vos; Marc J M Bonten; Tom van der Poll
The complement system facilitates clearance of Enterococcus faecium during murine peritonitis.
The Journal of infectious diseases 2010;201(4):544-52.
2010: Rosa van Mansfeld; Irene Jongerden; Martin Bootsma; Anton Buiting; Marc Bonten; Rob Willems
The population genetics of Pseudomonas aeruginosa isolates from different patient populations exhibits high-level host specificity.
PloS one 2010;5(10):e13482.
2010: Willem van Schaik; Janetta Top; David R Riley; Jos Boekhorst; Joyce E P Vrijenhoek; Claudia M E Schapendonk; Antoni P A Hendrickx; Isaäc J Nijman; Marc J M Bonten; Hervé Tettelin; Rob Willems
Pyrosequencing-based comparative genome analysis of the nosocomial pathogen Enterococcus faecium and identification of a large transferable pathogenicity island.
BMC genomics 2010;11():239.
2009: Rosa van Mansfeld; Rob Willems; Roland Brimicombe; Harry Heijerman; Ferdinand Teding van Berkhout; Tom Wolfs; Cornelis van der Ent; Marc Bonten
Pseudomonas aeruginosa genotype prevalence in Dutch cystic fibrosis patients and age dependency of colonization by various P. aeruginosa sequence types.
Journal of clinical microbiology 2009;47(12):4096-101.
2009: Rob Willems; Willem van Schaik
Transition of Enterococcus faecium from commensal organism to nosocomial pathogen.
Future microbiology 2009;4(9):1125-35.
2009: Antoni P A Hendrickx; Miranda van Luit-Asbroek; Claudia M E Schapendonk; Willem J B Van Wamel; Johanna C Braat; Lucas M Wijnands; Marc J M Bonten; Rob Willems
SgrA, a nidogen-binding LPXTG surface adhesin implicated in biofilm formation, and EcbA, a collagen binding MSCRAMM, are two novel adhesins of hospital-acquired Enterococcus faecium.
Infection and immunity 2009;77(11):5097-106.
2009: Masja Leendertse; Esther Heikens; Lucas M Wijnands; Miranda van Luit-Asbroek; Gwendoline J D Teske; Joris J T H Roelofs; Marc J M Bonten; Tom van der Poll; Rob Willems
Enterococcal surface protein transiently aggravates Enterococcus faecium-induced urinary tract infection in mice.
The Journal of infectious diseases 2009;200(7):1162-5.
2009: Antoni P A Hendrickx; Rob Willems; Marc J M Bonten; Willem van Schaik
LPxTG surface proteins of enterococci.
Trends in microbiology 2009;17(9):423-30.
2009: Masja Leendertse; Rob Willems; G Anneke Oei; Sandrine Florquin; Marc J M Bonten; Tom van der Poll
Intestinal Enterococcus faecium colonization improves host defense during polymicrobial peritonitis.
The Journal of infectious diseases 2009;200(5):735-44.
2009: Shahreen A Chowdhury; Cesar A Arias; Sreedhar R Nallapareddy; Jinnethe Reyes; Rob Willems; Barbara E Murray
A trilocus sequence typing scheme for hospital epidemiology and subspecies differentiation of an important nosocomial pathogen, Enterococcus faecalis.
Journal of clinical microbiology 2009;47(9):2713-9.
2009: Masja Leendertse; Rob Willems; Ida A J Giebelen; Petra S van den Pangaart; Marc J M Bonten; Tom van der Poll
The acute-phase response impairs host defence against Enterococcus faecium peritonitis.
Immunology 2009;128(1 Suppl):e335-42.
2009: Jinglu Sun; Xiaobo Song; Bjørn-Erik Kristiansen; Anne Kjaereng; Rob Willems; Harald M Eriksen; Arnfinn Sundsfjord; Johanna E Sollid
Occurrence, population structure, and antimicrobial resistance of enterococci in marginal and apical periodontitis.
Journal of clinical microbiology 2009;47(7):2218-25.
2009: X Zhu; B Zheng; Shan Wang; Rob Willems; F Xue; X Cao; Yan Li; S Bo; Jun Liu
Molecular characterisation of outbreak-related strains of vancomycin-resistant Enterococcus faecium from an intensive care unit in Beijing, China.
The Journal of hospital infection 2009;72(2):147-54.
2009: Shonna M McBride; Phillip S Coburn; Arto S Baghdayan; Rob Willems; Maria J Grande; Nathan Shankar; Michael S Gilmore
Genetic variation and evolution of the pathogenicity island of Enterococcus faecalis.
Journal of bacteriology 2009;191(10):3392-402.
2009: Masja Leendertse; Rob Willems; Ida A J Giebelen; Sandrine Florquin; Petra S van den Pangaart; Marc J M Bonten; Tom van der Poll
Cecal ligation and puncture induced sepsis impairs host defense against Enterococcus faecium peritonitis.
Intensive care medicine 2009;35(5):924-32.
2009: Peter Damborg; Janetta Top; Antoni P A Hendrickx; Susan Dawson; Rob Willems; Luca Guardabassi
Dogs are a reservoir of ampicillin-resistant Enterococcus faecium lineages associated with human infections.
Applied and environmental microbiology 2009;75(8):2360-5.
2009: Masja Leendertse; Rob Willems; Ida A J Giebelen; Joris J T H Roelofs; Nico van Rooijen; Marc J M Bonten; Tom van der Poll
Peritoneal macrophages are important for the early containment of Enterococcus faecium peritonitis in mice.
Innate immunity 2009;15(1):3-12.
2009: Patricia Ruiz-Garbajosa; Rosa del Campo; Teresa M Coque; Angel Asensio; Marc J M Bonten; Rob Willems; Fernando Baquero; Rafael Cantón
Longer intestinal persistence of Enterococcus faecalis compared to Enterococcus faecium clones in intensive-care-unit patients.
Journal of clinical microbiology 2009;47(2):345-51.
2009: Neeltje Carpaij; Ad C Fluit; Jodi Lindsay; Marc Jm Bonten; Rob Willems
New methods to analyse microarray data that partially lack a reference signal.
BMC genomics 2009;10():522.
2009: Masja Leendertse; Rob Willems; Ida A J Giebelen; Joris J T H Roelofs; Janetta Top; Marc J M Bonten; Tom van der Poll
Intestinal colonization with Enterococcus faecium does not influence pulmonary defense against Pseudomonas aeruginosa in mice.
PloS one 2009;4(8):e6775.
2009: Esther Heikens; Masja Leendertse; Lucas M Wijnands; Miranda van Luit-Asbroek; Marc J M Bonten; Tom van der Poll; Rob Willems
Enterococcal surface protein Esp is not essential for cell adhesion and intestinal colonization of Enterococcus faecium in mice.
BMC microbiology 2009;9():19.
2009: Masja Leendertse; Rob Willems; Ida A J Giebelen; Joris J T H Roelofs; Marc J M Bonten; Tom van der Poll
Neutrophils are essential for rapid clearance of Enterococcus faecium in mice.
Infection and immunity 2009;77(1):485-91.
2008: Marieke J A de Regt; Lotte E van der Wagen; Janetta Top; Hetty E M Blok; T E M Hopmans; Adriaan W Dekker; Ronald J Hené; Peter D Siersema; Rob Willems; Marc J M Bonten
High acquisition and environmental contamination rates of CC17 ampicillin-resistant Enterococcus faecium in a Dutch hospital.
The Journal of antimicrobial chemotherapy 2008;62(6):1401-6.
2008: G Werner; T M Coque; A M Hammerum; R Hope; W Hryniewicz; A Johnson; I Klare; K G Kristinsson; R Leclercq; C H Lester; M Lillie; Carla Novais; B Olsson-Liljequist; L V Peixe; E Sadowy; G S Simonsen; J Top; J Vuopio-Varkila; Rob Willems; W Witte; N Woodford
Emergence and spread of vancomycin resistance among enterococci in Europe.
Euro surveillance : bulletin Européen sur les maladies transmissibles = European communicable disease bulletin 2008;13(47):.
2008: Esther Heikens; Willem van Schaik; Helen L Leavis; Marc J M Bonten; Rob Willems
Identification of a novel genomic island specific to hospital-acquired clonal complex 17 Enterococcus faecium isolates.
Applied and environmental microbiology 2008;74(22):7094-7.
2008: Antoni P A Hendrickx; Marc J M Bonten; Miranda van Luit-Asbroek; Claudia M E Schapendonk; Angela H M Kragten; Rob Willems
Expression of two distinct types of pili by a hospital-acquired Enterococcus faecium isolate.
Microbiology (Reading, England) 2008;154(Pt 10):3212-23.
2008: Risma Ikawaty; Rob Willems; Adrienne T A Box; Jan Verhoef; Ad C Fluit
Novel multiple-locus variable-number tandem-repeat analysis method for rapid molecular typing of human Staphylococcus aureus.
Journal of clinical microbiology 2008;46(9):3147-51.
2008: Masja Leendertse; Rob Willems; Ida A J Giebelen; Petra S van den Pangaart; W Joost Wiersinga; Alex F de Vos; Sandrine Florquin; Marc J M Bonten; Tom van der Poll
TLR2-dependent MyD88 signaling contributes to early host defense in murine Enterococcus faecium peritonitis.
Journal of immunology (Baltimore, Md. : 1950) 2008;180(7):4865-74.
2008: Janetta Top; Rob Willems; Marc J M Bonten
Emergence of CC17 Enterococcus faecium: from commensal to hospital-adapted pathogen.
FEMS immunology and medical microbiology 2008;52(3):297-308.
2008: Janetta Top; N M I Banga; R Hayes; Rob Willems; Marc J M Bonten; M K Hayden
Comparison of multiple-locus variable-number tandem repeat analysis and pulsed-field gel electrophoresis in a setting of polyclonal endemicity of vancomycin-resistant Enterococcus faecium.
Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases 2008;14(4):363-9.
2008: Balázs Libisch; Zorica Lepsanovic; Janetta Top; Mónika Muzslay; Marianne Konkoly-Thege; Mária Gacs; Boglárka Balogh; Miklós Füzi; Rob Willems
Molecular characterization of vancomycin-resistant Enterococcus spp. clinical isolates from Hungary and Serbia.
Scandinavian journal of infectious diseases 2008;40(10):778-84.
2008: Janetta Top; Rob Willems; Saskia van der Velden; Miranda Asbroek; Marc J M Bonten
Emergence of clonal complex 17 Enterococcus faecium in The Netherlands.
Journal of clinical microbiology 2008;46(1):214-9.
2007: Antoni P A Hendrickx; Willem J B Van Wamel; George Posthuma; Marc J M Bonten; Rob Willems
Five genes encoding surface-exposed LPXTG proteins are enriched in hospital-adapted Enterococcus faecium clonal complex 17 isolates.
Journal of bacteriology 2007;189(22):8321-32.
2007: Esther Heikens; Marc J M Bonten; Rob Willems
Enterococcal surface protein Esp is important for biofilm formation of Enterococcus faecium E1162.
Journal of bacteriology 2007;189(22):8233-40.
2007: Patricia Ruiz-Garbajosa; Teresa M Coque; Rafael Cantón; Rob Willems; Fernando Baquero; Rosa del Campo
[High-risk clonal complexes CC2 and CC9 are widely distributed among Enterococcus faecalis hospital isolates recovered in Spain].
Enfermedades infecciosas y microbiología clínica 2007;25(8):513-8.
2007: Rob Willems; Marc J M Bonten
Glycopeptide-resistant enterococci: deciphering virulence, resistance and epidemicity.
Current opinion in infectious diseases 2007;20(4):384-90.
2007: Janetta Top; Rob Willems; Hetty E M Blok; M de Regt; KP Jalink; Annet Troelstra; Abraham Goorhuis; Marc J M Bonten
Ecological replacement of Enterococcus faecalis by multiresistant clonal complex 17 Enterococcus faecium.
Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases 2007;13(3):316-9.
2007: Willem J B Van Wamel; Antoni P A Hendrickx; Marc J M Bonten; Janetta Top; George Posthuma; Rob Willems
Growth condition-dependent Esp expression by Enterococcus faecium affects initial adherence and biofilm formation.
Infection and immunity 2007;75(2):924-31.
2007: Helen L Leavis; Rob Willems; Willem J B Van Wamel; Frank H J Schuren; Martien P M Caspers; Marc J M Bonten
Insertion sequence-driven diversification creates a globally dispersed emerging multiresistant subspecies of E. faecium.
PLoS pathogens 2007;3(1):e7.
2007: Magdalena Kawalec; Zbigniew Pietras; Emilia Daniłowicz; Aleksandra Jakubczak; Marek Gniadkowski; Waleria Hryniewicz; Rob Willems
Clonal structure of Enterococcus faecalis isolated from Polish hospitals: characterization of epidemic clones.
Journal of clinical microbiology 2007;45(1):147-53.
2006: Patricia Ruiz-Garbajosa; Rafael Cantón; Vicente Pintado; Teresa M Coque; Rob Willems; Fernando Baquero; Rosa del Campo
Genetic and phenotypic differences among Enterococcus faecalis clones from intestinal colonisation and invasive disease.
Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases 2006;12(12):1193-8.
2006: Nathan Shankar; Arto S Baghdayan; Rob Willems; Anette M Hammerum; Lars Bogø Jensen
Presence of pathogenicity island genes in Enterococcus faecalis isolates from pigs in Denmark.
Journal of clinical microbiology 2006;44(11):4200-3.
2006: Helen L Leavis; Marc J M Bonten; Rob Willems
Identification of high-risk enterococcal clonal complexes: global dispersion and antibiotic resistance.
Current opinion in microbiology 2006;9(5):454-60.
2006: Patricia Ruiz-Garbajosa; Marc J M Bonten; D Ashley Robinson; Janetta Top; Sreedhar Nallapareddy; Carmen Torres; Teresa M Coque; Rafael Cantón; Fernando Baquero; Barbara E Murray; Rosa del Campo; Rob Willems
Multilocus sequence typing scheme for Enterococcus faecalis reveals hospital-adapted genetic complexes in a background of high rates of recombination.
Journal of clinical microbiology 2006;44(6):2220-8.
2006: Ellen M Mascini; Annet Troelstra; M Beitsma; Hetty E M Blok; KP Jalink; T E M Hopmans; Ad C Fluit; R J Hene; Rob Willems; Jan Verhoef; Marc J M Bonten
Genotyping and preemptive isolation to control an outbreak of vancomycin-resistant Enterococcus faecium.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2006;42(6):739-46.
2006: Helen L Leavis; Rob Willems; Janetta Top; Marc J M Bonten
High-level ciprofloxacin resistance from point mutations in gyrA and parC confined to global hospital-adapted clonal lineage CC17 of Enterococcus faecium.
Journal of clinical microbiology 2006;44(3):1059-64.
2006: Ricardo Titze-de-Almeida; Alex Van Belkum; Maria Sueli S Felipe; Rosemeire C Zanella; Janetta Top; Rob Willems
Multilocus sequence typing of hospital-associated Enterococcus faecium from Brazil reveals their unique evolutionary history.
Microbial drug resistance (Larchmont, N.Y.) 2006;12(2):121.
2005: W J B Wannet; Emile Spalburg; M E O C Heck; Gerlinde N Pluister; E Tiemersma; Rob Willems; Xander W Huijsdens; Albert J de Neeling; Jerome Etienne
Emergence of virulent methicillin-resistant Staphylococcus aureus strains carrying Panton-Valentine leucocidin genes in The Netherlands.
Journal of clinical microbiology 2005;43(7):3341-5.
2005: Teresa M Coque; Rob Willems; Jesús Fortún; Janetta Top; Sergio Diz; Elena Loza; Rafael Cantón; Fernando Baquero
Population structure of Enterococcus faecium causing bacteremia in a Spanish university hospital: setting the scene for a future increase in vancomycin resistance?
Antimicrobial agents and chemotherapy 2005;49(7):2693-700.
2005: Saskia Nijssen; Alice Florijn; Janetta Top; Rob Willems; Ad C Fluit; Marc J M Bonten
Unnoticed spread of integron-carrying Enterobacteriaceae in intensive care units.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2005;41(1):1-9.
2005: Rob Willems; Janetta Top; Marga van Santen; D Ashley Robinson; Teresa M Coque; Fernando Baquero; Hajo Grundmann; Marc J M Bonten
Global spread of vancomycin-resistant Enterococcus faecium from distinct nosocomial genetic complex.
Emerging infectious diseases 2005;11(6):821-8.
2005: E De Leener; A Martel; Evelyne De Graef; Janetta Top; P Butaye; Freddy Haesebrouck; Rob Willems; Annemie Decostere
Molecular analysis of human, porcine, and poultry Enterococcus faecium isolates and their erm(B) genes.
Applied and environmental microbiology 2005;71(5):2766-70.
2005: J Gooskens; A J De Neeling; Rob Willems; J W Van 't Wout; E J Kuijper
Streptococcal toxic shock syndrome by an iMLS resistant M type 77 Streptococcus pyogenes in the Netherlands.
Scandinavian journal of infectious diseases 2005;37(2):85-9.
2004: Ricardo Titze-de-Almeida; Rob Willems; Janetta Top; Isabela Pereira Rodrigues; Renato Fonseca Ferreira; Hélène Boelens; Maria Cristina C Brandileone; Rosemeire C Zanella; Maria Sueli S Felipe; Alex Van Belkum
Multilocus variable-number tandem-repeat polymorphism among Brazilian Enterococcus faecalis strains.
Journal of clinical microbiology 2004;42(10):4879-81.
2004: Janetta Top; Leo M Schouls; Marc J M Bonten; Rob Willems
Multiple-locus variable-number tandem repeat analysis, a novel typing scheme to study the genetic relatedness and epidemiology of Enterococcus faecium isolates.
Journal of clinical microbiology 2004;42(10):4503-11.
2004: W J B Wannet; Emile Spalburg; M E O C Heck; Gerlinde N Pluister; Rob Willems; Albert J de Neeling
Widespread dissemination in The Netherlands of the epidemic berlin methicillin-resistant Staphylococcus aureus clone with low-level resistance to oxacillin.
Journal of clinical microbiology 2004;42(7):3077-82.
2004: Helen L Leavis; Rob Willems; Ellen M Mascini; Christina M.J.E, Vandenbroucke-Grauls; Marc J M Bonten
[Vancomycin resistant enterococci in the Netherlands].
Nederlands tijdschrift voor geneeskunde 2004;148(18):878-82.
2004: Stein Christian Mohn; Arve Ulvik; Roland Jureen; Rob Willems; Janetta Top; Helen L Leavis; Stig Harthug; Nina Langeland
Duplex real-time PCR assay for rapid detection of ampicillin-resistant Enterococcus faecium.
Antimicrobial agents and chemotherapy 2004;48(2):556-60.
2004: Helen L Leavis; Janetta Top; Nathan Shankar; Katrine Borgen; Marc J M Bonten; Jan D A Van Embden; Rob Willems
A novel putative enterococcal pathogenicity island linked to the esp virulence gene of Enterococcus faecium and associated with epidemicity.
Journal of bacteriology 2004;186(3):672-82.
2004: Roland Jureen; Stig Harthug; Steinar Sørnes; Asbjørn Digranes; Rob Willems; Nina Langeland
Comparative analysis of amplified fragment length polymorphism and pulsed field gel electrophoresis in a hospital outbreak and subsequent endemicity of ampicillin-resistant Enterococcus faecium.
FEMS immunology and medical microbiology 2004;40(1):33-9.
2003: Christina Routsi; Evangelia Platsouka; Rob Willems; Marc J M Bonten; Olga Paniara; George Saroglou; Charis Roussos
Detection of enterococcal surface protein gene (esp) and amplified fragment length polymorphism typing of glycopeptide-resistant Enterococcus faecium during its emergence in a Greek intensive care unit.
Journal of clinical microbiology 2003;41(12):5742-6.
2003: Rob Willems; Janetta Top; Derek J Smith; David I Roper; Sarah E North; Neil Woodford
Mutations in the DNA mismatch repair proteins MutS and MutL of oxazolidinone-resistant or -susceptible Enterococcus faecium.
Antimicrobial agents and chemotherapy 2003;47(10):3061-6.
2003: Helen L Leavis; Rob Willems; Janetta Top; Emile Spalburg; Ellen M Mascini; Ad C Fluit; Andy I M Hoepelman; Albert J de Neeling; Marc J M Bonten
Epidemic and nonepidemic multidrug-resistant Enterococcus faecium.
Emerging infectious diseases 2003;9(9):1108-15.
2003: Karola Waar; Rob Willems; Maarten J H Slooff; Hermie J M Harmsen; John E Degener
Molecular epidemiology of Enterococcus faecalis in liver transplant patients at University Hospital Groningen.
The Journal of hospital infection 2003;55(1):53-60.
2003: Lars Bogø Jensen; Rob Willems; Anthony E van den Bogaard
Genetic characterization of glycopeptide-resistant enterococci of human and animal origin from mixed pig and poultry farms.
APMIS : acta pathologica, microbiologica, et immunologica Scandinavica 2003;111(6):669-72.
2003: Roland Jureen; Janetta Top; Stein Christian Mohn; Stig Harthug; Nina Langeland; Rob Willems
Molecular characterization of ampicillin-resistant Enterococcus faecium isolates from hospitalized patients in Norway.
Journal of clinical microbiology 2003;41(6):2330-6.
2003: Guido Werner; Rob Willems; Bianca Hildebrandt; Ingo Klare; Wolfgang Witte
Influence of transferable genetic determinants on the outcome of typing methods commonly used for Enterococcus faecium.
Journal of clinical microbiology 2003;41(4):1499-506.
2003: Leo M Schouls; Sanne Reulen; Birgitta Duim; Jaap A Wagenaar; Rob Willems; Kate E Dingle; Frances M Colles; Jan D A Van Embden
Comparative genotyping of Campylobacter jejuni by amplified fragment length polymorphism, multilocus sequence typing, and short repeat sequencing: strain diversity, host range, and recombination.
Journal of clinical microbiology 2003;41(1):15-26.
2002: Teresa M Coque; Rob Willems; Rafael Cantón; Rosa del Campo; Fernando Baquero
High occurrence of esp among ampicillin-resistant and vancomycin-susceptible Enterococcus faecium clones from hospitalized patients.
The Journal of antimicrobial chemotherapy 2002;50(6):1035-8.
2002: Nienke Bruinsma; Rob Willems; Anthony E van den Bogaard; Marga G van Santen-Verheuvel; Nancy London; Christel Driessen; Ellen E Stobberingh
Different levels of genetic homogeneity in vancomycin-resistant and -susceptible Enterococcus faecium isolates from different human and animal sources analyzed by amplified-fragment length polymorphism.
Antimicrobial agents and chemotherapy 2002;46(9):2779-83.
2002: Katrine Borgen; Yngvild Wasteson; Hilde Kruse; Rob Willems
Vancomycin-resistant Enterococcus faecium (VREF) from Norwegian poultry cluster with VREF from poultry from the United Kingdom and The Netherlands in an amplified fragment length polymorphism genogroup.
Applied and environmental microbiology 2002;68(6):3133-7.
2002: Sylvain Brisse; Vivian Fussing; Ben Ridwan; Jan Verhoef; Rob Willems
Automated ribotyping of vancomycin-resistant Enterococcus faecium isolates.
Journal of clinical microbiology 2002;40(6):1977-84.
2002: Wieger L Homan; David Tribe; Simone Poznanski; Mei Li; Geoff Hogg; Emile Spalburg; Jan D A Van Embden; Rob Willems
Multilocus sequence typing scheme for Enterococcus faecium.
Journal of clinical microbiology 2002;40(6):1963-71.
2002: Karola Waar; Albrecht B Muscholl-Silberhorn; Rob Willems; Maarten J H Slooff; Hermie J M Harmsen; John E Degener
Genogrouping and incidence of virulence factors of Enterococcus faecalis in liver transplant patients differ from blood culture and fecal isolates.
The Journal of infectious diseases 2002;185(8):1121-7.
2002: Anthony E van den Bogaard; Rob Willems; Nancy London; Janetta Top; Ellen E Stobberingh
Antibiotic resistance of faecal enterococci in poultry, poultry farmers and poultry slaughterers.
The Journal of antimicrobial chemotherapy 2002;49(3):497-505.
2001: Marc J M Bonten; Rob Willems; Robert A Weinstein
Vancomycin-resistant enterococci: why are they here, and where do they come from?
The Lancet infectious diseases 2001;1(5):314-25.
2001: Rob Willems; Wieger L Homan; Janetta Top; Marga G van Santen-Verheuvel; David Tribe; X Manzioros; C Gaillard; Christina M.J.E, Vandenbroucke-Grauls; Ellen M Mascini; E van Kregten; Jan D A Van Embden; Marc J M Bonten
Variant esp gene as a marker of a distinct genetic lineage of vancomycin-resistant Enterococcus faecium spreading in hospitals.
Lancet 2001;357(9259):853-5.
2001: MA Schouten; Rob Willems; W A Kraak; Janetta Top; J A A Hoogkamp-Korstanje; Andreas Voss
Molecular analysis of Tn1546-like elements in vancomycin-resistant enterococci isolated from patients in Europe shows geographic transposon type clustering.
Antimicrobial agents and chemotherapy 2001;45(3):986-9.
2001: Kate E Dingle; Frances M Colles; D R A Wareing; Roisin Ure; Andrew J Fox; F E Bolton; H J Bootsma; Rob Willems; Rachel Urwin; Martin C J Maiden
Multilocus sequence typing system for Campylobacter jejuni.
Journal of clinical microbiology 2001;39(1):14-23.
2000: L F van der Steen; Marc J M Bonten; E van Kregten; J J Harssema-Poot; Rob Willems; C A Gaillard
[Vancomycin-resistant Enterococcus faecium outbreak in a nephrology ward].
Nederlands tijdschrift voor geneeskunde 2000;144(53):2568-72.
2000: Marc J M Bonten; Ellen M Mascini; Rob Willems; G J Timmer; C A Gaillard; Christina M.J.E, Vandenbroucke-Grauls
[What is to be done with vancomycin-resistant enterococcal infections?].
Nederlands tijdschrift voor geneeskunde 2000;144(53):2545-9.
2000: Albert J de Neeling; Marga G van Santen-Verheuvel; J Spaargaren; Rob Willems
Antimicrobial resistance of Neisseria gonorrhoeae and emerging ciprofloxacin resistance in the Netherlands, 1991 to 1998.
Antimicrobial agents and chemotherapy 2000;44(11):3184-5.
2000: Rob Willems; Janetta Top; Nicole van den Braak; Alex Van Belkum; Hubert P Endtz; DJ Mevius; Ellen E Stobberingh; Anthony E van den Bogaard; Jan D A Van Embden
Host specificity of vancomycin-resistant Enterococcus faecium.
The Journal of infectious diseases 2000;182(3):816-23.
1999: Ellen E Stobberingh; Anthony E van den Bogaard; Nancy London; Christel Driessen; Janetta Top; Rob Willems
Enterococci with glycopeptide resistance in turkeys, turkey farmers, turkey slaughterers, and (sub)urban residents in the south of The Netherlands: evidence for transmission of vancomycin resistance from animals to humans?
Antimicrobial agents and chemotherapy 1999;43(9):2215-21.
1999: Rob Willems; Janetta Top; Nicole van den Braak; Alex Van Belkum; DJ Mevius; Giel Hendriks; Marga G van Santen-Verheuvel; Jan D A Van Embden
Molecular diversity and evolutionary relationships of Tn1546-like elements in enterococci from humans and animals.
Antimicrobial agents and chemotherapy 1999;43(3):483-91.
1999: BM van den Berg; Henry Beekhuizen; Rob Willems; Frits R Mooi; Ralph van Furth
Role of Bordetella pertussis virulence factors in adherence to epithelial cell lines derived from the human respiratory tract.
Infection and immunity 1999;67(3):1056-62.
1998: CA Geuijen; Rob Willems; Peter Hoogerhout; Wouter C Puijk; Rob H Meloen; Frits R Mooi
Identification and characterization of heparin binding regions of the Fim2 subunit of Bordetella pertussis.
Infection and immunity 1998;66(5):2256-63.
1998: Rob Willems; J Kamerbeek; CA Geuijen; Janetta Top; H Gielen; W Gaastra; Frits R Mooi
The efficacy of a whole cell pertussis vaccine and fimbriae against Bordetella pertussis and Bordetella parapertussis infections in a respiratory mouse model.
Vaccine 1998;16(4):410-6.
1998: Frits R Mooi; HF van Oirschot; Kees J Heuvelman; Han G J van der Heide; W Gaastra; Rob Willems
Polymorphism in the Bordetella pertussis virulence factors P.69/pertactin and pertussis toxin in The Netherlands: temporal trends and evidence for vaccine-driven evolution.
Infection and immunity 1998;66(2):670-5.
1997: CA Geuijen; Rob Willems; M Bongaerts; Janetta Top; H Gielen; Frits R Mooi
Role of the Bordetella pertussis minor fimbrial subunit, FimD, in colonization of the mouse respiratory tract.
Infection and immunity 1997;65(10):4222-8.
1996: P H Savelkoul; D P de Kerf; Rob Willems; Frits R Mooi; Bernard A.M. Van der Zeijst; Wim Gaastra
Characterization of the fim2 and fim3 fimbrial subunit genes of Bordetella bronchiseptica: roles of Fim2 and Fim3 fimbriae and flagella in adhesion.
Infection and immunity 1996;64(12):5098-105.
1996: C A Geuijen; Rob Willems; Frits R Mooi
The major fimbrial subunit of Bordetella pertussis binds to sulfated sugars.
Infection and immunity 1996;64(7):2657-65.
1996: E M Bik; Annelies Bunschoten; Rob Willems; A C Chang; Frits R Mooi
Genetic organization and functional analysis of the otn DNA essential for cell-wall polysaccharide synthesis in Vibrio cholerae O139.
Molecular microbiology 1996;20(4):799-811.
1994: Rob Willems; C Geuijen; Han G J van der Heide; G Renauld; P Bertin; Willem van den Akker; Camille Locht; Frits R Mooi
Mutational analysis of the Bordetella pertussis fim/fha gene cluster: identification of a gene with sequence similarities to haemolysin accessory genes involved in export of FHA.
Molecular microbiology 1994;11(2):337-47.
1993: Rob Willems; C Geuijen; Han G J van der Heide; M Matheson; A Robinson; L F Versluis; R Ebberink; J Theelen; Frits R Mooi
Isolation of a putative fimbrial adhesin from Bordetella pertussis and the identification of its gene.
Molecular microbiology 1993;9(3):623-34.
1992: Douwe Bakker; P T Willemsen; Rob Willems; T T Huisman; F R Mooi; Bauke Oudega; F Stegehuis; F K de Graaf
Identification of minor fimbrial subunits involved in biosynthesis of K88 fimbriae.
Journal of bacteriology 1992;174(20):6350-8.
1992: Rob Willems; Han G J van der Heide; Frits R Mooi
Characterization of a Bordetella pertussis fimbrial gene cluster which is located directly downstream of the filamentous haemagglutinin gene.
Molecular microbiology 1992;6(18):2661-71.
1990: Rob Willems; A Paul; Han G J van der Heide; A R ter Avest; Frits R Mooi
Fimbrial phase variation in Bordetella pertussis: a novel mechanism for transcriptional regulation.
The EMBO journal 1990;9(9):2803-9.
1990: Ed Schuuring; B J van der Leede; Rob Willems; H Daams; Martin van der Valk; Marc J van de Vijver; F van Leeuwen; Arnoud Sonnenberg; Roel Nusse
Differentiation-dependent expression of provirus-activated int-1 oncogene in clonal cell lines derived from a mouse mammary tumor.
Oncogene 1990;5(4):459-65.