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Ralf Baumeister

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Eva D Runkel; Ralf Baumeister; Shu Liu; Ekkehard Schulze
Surveillance-activated defenses block the ROS-induced mitochondrial unfolded protein response.
Piero Dalle Pezze; Sven Fischer; Markus Gödel; Tobias B Huber; Elke Neumann-Haefelin; Mirja T Prentzell; Daryl P Shanley; Annika G Sonntag; Ralf Baumeister; Antje Thien; Kathrin Thedieck
A dynamic network model of mTOR signaling reveals TSC-independent mTORC2 regulation.
Shu Liu; Ekkehard Schulze; Ralf Baumeister
Temperature- and touch-sensitive neurons couple CNG and TRPV channel activities to control heat avoidance in Caenorhabditis elegans.

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2013: Eva D Runkel; Ralf Baumeister; Shu Liu; Ekkehard Schulze
Surveillance-activated defenses block the ROS-induced mitochondrial unfolded protein response.
PLoS genetics 2013;9(3):e1003346.
2012: Piero Dalle Pezze; Sven Fischer; Markus Gödel; Tobias B Huber; Elke Neumann-Haefelin; Mirja T Prentzell; Daryl P Shanley; Annika G Sonntag; Ralf Baumeister; Antje Thien; Kathrin Thedieck
A dynamic network model of mTOR signaling reveals TSC-independent mTORC2 regulation.
Science signaling 2012;5(217):ra25.
2012: Shu Liu; Ekkehard Schulze; Ralf Baumeister
Temperature- and touch-sensitive neurons couple CNG and TRPV channel activities to control heat avoidance in Caenorhabditis elegans.
PloS one 2012;7(3):e32360.
2011: Luca Rizzini; Jean-Jacques Favory; Catherine Cloix; Davide Faggionato; Andrew O'Hara; Eirini Kaiserli; Ralf Baumeister; Eberhard Schäfer; Ferenc Nagy; Gareth I Jenkins; Roman Ulm
Perception of UV-B by the Arabidopsis UVR8 protein.
Science (New York, N.Y.) 2011;332(6025):103-6.
2011: Tim O Lankisch; Jochen Metzger; Ahmed A Negm; Katja Vosskuhl; Eric Schiffer; Justyna Siwy; Tobias J Weismüller; Andrea S Schneider; Kathrin Thedieck; Ralf Baumeister; Petra Zürbig; Eva M Weissinger; Michael P Manns; Harald Mischak; Jochen Wedemeyer
Bile proteomic profiles differentiate cholangiocarcinoma from primary sclerosing cholangitis and choledocholithiasis.
Hepatology (Baltimore, Md.) 2011;53(3):875-84.
2011: Nicola Wanner; Ralf Baumeister; Tobias B Huber; Foteini Noutsou; Gerd Walz; Elke Neumann-Haefelin
Functional and spatial analysis of C. elegans SYG-1 and SYG-2, orthologs of the Neph/nephrin cell adhesion module directing selective synaptogenesis.
PloS one 2011;6(8):e23598.
2010: Daniela Fusco; Manuela Vargiolu; Michele Vidone; Elisa Mariani; Lucia Fiammetta Pennisi; Elena Bonora; Sabina Capellari; Dietmar Dirnberger; Ralf Baumeister; Paolo Martinelli; Giovanni Romeo
The RET51/FKBP52 complex and its involvement in Parkinson disease.
Human molecular genetics 2010;19(14):2804-16.
2010: Elke Neumann-Haefelin; Albrecht Kramer-Zucker; Krasimir Slanchev; Björn Hartleben; Foteini Noutsou; Katrin Martin; Nicola Wanner; Alexander Ritter; Markus Gödel; Philip Pagel; Xiao Fu; Alexandra Müller; Ralf Baumeister; Gerd Walz; Tobias B Huber
A model organism approach: defining the role of Neph proteins as regulators of neuron and kidney morphogenesis.
Human molecular genetics 2010;19(12):2347-59.
2010: Ursula Schäffer; Andreas Schlosser; Kristian M Müller; Angelika Schäfer; Nenad Katava; Ralf Baumeister; Ekkehard Schulze
SnAvi--a new tandem tag for high-affinity protein-complex purification.
Nucleic acids research 2010;38(6):e91.
2009: Manuela Vargiolu; Daniela Fusco; Ivana Kurelac; Dietmar Dirnberger; Ralf Baumeister; Isabella Morra; Antonio Melcarne; Roberto Rimondini; Giovanni Romeo; Elena Bonora
The tyrosine kinase receptor RET interacts in vivo with aryl hydrocarbon receptor-interacting protein to alter survivin availability.
The Journal of clinical endocrinology and metabolism 2009;94(7):2571-8.
2009: Julia Sämann; Jan Hegermann; Erika von Gromoff; Stefan Eimer; Ralf Baumeister; Enrico Schmidt
Caenorhabditits elegans LRK-1 and PINK-1 act antagonistically in stress response and neurite outgrowth.
The Journal of biological chemistry 2009;284(24):16482-91.
2008: Elke Neumann-Haefelin; Wenjing Qi; Elisabeth Finkbeiner; Gerd Walz; Ralf Baumeister; Maren Hertweck
SHC-1/p52Shc targets the insulin/IGF-1 and JNK signaling pathways to modulate life span and stress response in C. elegans.
Genes & development 2008;22(19):2721-35.
2008: Susanne Schöbel; Stephanie Neumann; Maren Hertweck; Bastian Dislich; Peer-Hendrik Kuhn; Elisabeth Kremmer; Brian Seed; Ralf Baumeister; Christian Haass; Stefan F Lichtenthaler
A novel sorting nexin modulates endocytic trafficking and alpha-secretase cleavage of the amyloid precursor protein.
The Journal of biological chemistry 2008;283(21):14257-68.
2008: Dietmar Dirnberger; Monika Messerschmid; Ralf Baumeister
An optimized split-ubiquitin cDNA-library screening system to identify novel interactors of the human Frizzled 1 receptor.
Nucleic acids research 2008;36(6):e37.
2008: Jennifer M A Tullet; Maren Hertweck; Jae Hyung An; Joseph Baker; Ji Yun Hwang; Shu Liu; Riva P Oliveira; Ralf Baumeister; T Keith Blackwell
Direct inhibition of the longevity-promoting factor SKN-1 by insulin-like signaling in C. elegans.
Cell 2008;132(6):1025-38.
2007: Oyunbileg Nyamsuren; Davide Faggionato; Wiebke Loch; Ekkehard Schulze; Ralf Baumeister
A mutation in CHN-1/CHIP suppresses muscle degeneration in Caenorhabditis elegans.
Developmental biology 2007;312(1):193-202.
2007: Enrico Schmidt; Mark Seifert; Ralf Baumeister
Caenorhabditis elegans as a model system for Parkinson's disease.
Neuro-degenerative diseases 2007;4(2-3):199-217.
2006: Mark Seifert; Enrico Schmidt; Ralf Baumeister
The genetics of synapse formation and function in Caenorhabditis elegans.
Cell and tissue research 2006;326(2):273-85.
2006: Ralf Baumeister; Elke Schaffitzel; Maren Hertweck
Endocrine signaling in Caenorhabditis elegans controls stress response and longevity.
The Journal of endocrinology 2006;190(2):191-202.
2006: Aya Yamasaki; Stefan Eimer; Masayasu Okochi; Agata Smialowska; Christoph Kaether; Ralf Baumeister; Christian Haass; Harald Steiner
The GxGD motif of presenilin contributes to catalytic function and substrate identification of gamma-secretase.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2006;26(14):3821-8.
2006: Agata Smialowska; Ralf Baumeister
Presenilin function in Caenorhabditis elegans.
Neuro-degenerative diseases 2006;3(4-5):227-32.
2005: Wolfdieter Springer; Thorsten Hoppe; Enrico Schmidt; Ralf Baumeister
A Caenorhabditis elegans Parkin mutant with altered solubility couples alpha-synuclein aggregation to proteotoxic stress.
Human molecular genetics 2005;14(22):3407-23.
2005: Britta Spanier; Stephen R Stürzenbaum; Lindy M Holden-Dye; Ralf Baumeister
Caenorhabditis elegans neprilysin NEP-1: an effector of locomotion and pharyngeal pumping.
Journal of molecular biology 2005;352(2):429-37.
2005: giuseppe cassata; Gidi Shemer; Paolo Morandi; Roland Donhauser; Benjamin Podbilewicz; Ralf Baumeister
ceh-16/engrailed patterns the embryonic epidermis of Caenorhabditis elegans.
Development (Cambridge, England) 2005;132(4):739-49.
2005: Maren Hertweck; Ralf Baumeister
Automated assays to study longevity in C. elegans.
Mechanisms of ageing and development 2005;126(1):139-45.
2004: Assunta Croce; giuseppe cassata; Andrea Disanza; Maria Cristina Gagliani; Carlo Tacchetti; Maria Grazia Malabarba; Marie-France Carlier; Giorgio Scita; Ralf Baumeister; Pier Paolo Di Fiore
A novel actin barbed-end-capping activity in EPS-8 regulates apical morphogenesis in intestinal cells of Caenorhabditis elegans.
Nature cell biology 2004;6(12):1173-9.
2004: Ralf Baumeister; Maren Hertweck
Genes, longevity, and technology: meeting report from the 2nd conference on functional genomics of aging in Crete.
Science of aging knowledge environment : SAGE KE 2004;2004(40):pe37.
2004: Barbara Meissner; Michael Boll; Hannelore Daniel; Ralf Baumeister
Deletion of the intestinal peptide transporter affects insulin and TOR signaling in Caenorhabditis elegans.
The Journal of biological chemistry 2004;279(35):36739-45.
2004: S C Swain; K Keusekotten; Ralf Baumeister; Stephen R Stürzenbaum
C. elegans metallothioneins: new insights into the phenotypic effects of cadmium toxicosis.
Journal of molecular biology 2004;341(4):951-59.
2004: Thorsten Hoppe; giuseppe cassata; José M Barral; Wolfdieter Springer; Alex H Hutagalung; Henry F Epstein; Ralf Baumeister
Regulation of the myosin-directed chaperone UNC-45 by a novel E3/E4-multiubiquitylation complex in C. elegans.
Cell 2004;118(3):337-49.
2004: Jörg Höflich; Patricia M Berninsone; Christine Göbel; Maria Joao Gravato-Nobre; Brian J Libby; Creg Darby; Samuel M Politz; Jonathan Hodgkin; Carlos B Hirschberg; Ralf Baumeister
Loss of srf-3-encoded nucleotide sugar transporter activity in Caenorhabditis elegans alters surface antigenicity and prevents bacterial adherence.
The Journal of biological chemistry 2004;279(29):30440-8.
2004: Maren Hertweck; Christine Göbel; Ralf Baumeister
C. elegans SGK-1 is the critical component in the Akt/PKB kinase complex to control stress response and life span.
Developmental cell 2004;6(4):577-88.
2004: Evelyn Braungart; Manfred Gerlach; Peter Riederer; Ralf Baumeister; Marius C Hoener
Caenorhabditis elegans MPP+ model of Parkinson's disease for high-throughput drug screenings.
Neuro-degenerative diseases 2004;1(4-5):175-83.
2003: Bernard Lakowski; Stefan Eimer; Christine Göbel; Andreas Böttcher; Babett Wagler; Ralf Baumeister
Two suppressors of sel-12 encode C2H2 zinc-finger proteins that regulate presenilin transcription in Caenorhabditis elegans.
Development (Cambridge, England) 2003;130(10):2117-28.
2003: Maren Hertweck; Thorsten Hoppe; Ralf Baumeister
C. elegans, a model for aging with high-throughput capacity.
Experimental gerontology 2003;38(3):345-6.
2002: Susanne Klumpp; Jan Hermesmeier; Dagmar Selke; Ralf Baumeister; Roland Kellner; Josef Krieglstein
Protein histidine phosphatase: a novel enzyme with potency for neuronal signaling.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2002;22(12):1420-4.
2002: Stefan Eimer; Roland Donhauser; Ralf Baumeister
The Caenorhabditis elegans presenilin sel-12 is required for mesodermal patterning and muscle function.
Developmental biology 2002;251(1):178-92.
2002: Stefan Eimer; Bernard Lakowski; Roland Donhauser; Ralf Baumeister
Loss of spr-5 bypasses the requirement for the C.elegans presenilin sel-12 by derepressing hop-1.
The EMBO journal 2002;21(21):5787-96.
2002: Ralf Baumeister; Liming Ge
The worm in us - Caenorhabditis elegans as a model of human disease.
Trends in biotechnology 2002;20(4):147-8.
2002: Ralf Baumeister
Cross-species studies for target validation.
Briefings in functional genomics & proteomics 2002;1(1):53-65.
2001: Harald Steiner; Tamas Revesz; M Neumann; H Romig; MG Grim; B Pesold; Hans A Kretzschmar; John Hardy; Janice L Holton; Ralf Baumeister; Henry Houlden; Christian Haass
A pathogenic presenilin-1 deletion causes abberrant Abeta 42 production in the absence of congophilic amyloid plaques.
The Journal of biological chemistry 2001;276(10):7233-9.
2000: Masayasu Okochi; Stefan Eimer; A Bottcher; Ralf Baumeister; H Romig; Jochen Walter; Anja Capell; Harald Steiner; Christian Haass
A loss of function mutant of the presenilin homologue SEL-12 undergoes aberrant endoproteolysis in Caenorhabditis elegans and increases abeta 42 generation in human cells.
The Journal of biological chemistry 2000;275(52):40925-32.
2000: Harald Steiner; Marcus Kostka; H Romig; G Basset; B Pesold; John Hardy; Anja Capell; Liane Meyn; M L Grim; Ralf Baumeister; K Fechteler; Christian Haass
Glycine 384 is required for presenilin-1 function and is conserved in bacterial polytopic aspartyl proteases.
Nature cell biology 2000;2(11):848-51.
2000: giuseppe cassata; S Röhrig; F Kuhn; Hans-Peter Hauri; Ralf Baumeister; Thomas R Bürglin
The Caenorhabditis elegans Ldb/NLI/Clim orthologue ldb-1 is required for neuronal function.
Developmental biology 2000;226(1):45-56.
2000: N Wittenburg; Stefan Eimer; Bernard Lakowski; S Röhrig; C Rudolph; Ralf Baumeister
Presenilin is required for proper morphology and function of neurons in C. elegans.
Nature 2000;406(6793):306-9.
2000: S Röhrig; I Röckelein; Roland Donhauser; Ralf Baumeister
Protein interaction surface of the POU transcription factor UNC-86 selectively used in touch neurons.
The EMBO journal 2000;19(14):3694-703.
2000: I Röckelein; S Röhrig; Roland Donhauser; Stefan Eimer; Ralf Baumeister
Identification of amino acid residues in the Caenorhabditis elegans POU protein UNC-86 that mediate UNC-86-MEC-3-DNA ternary complex formation.
Molecular and cellular biology 2000;20(13):4806-13.
2000: L Kulic; Jochen Walter; Gerd Multhaup; David B Teplow; Ralf Baumeister; H Romig; Anja Capell; Harald Steiner; Christian Haass
Separation of presenilin function in amyloid beta-peptide generation and endoproteolysis of Notch.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(11):5913-8.
2000: Anja Capell; Harald Steiner; H Romig; S Keck; Miriam Baader; MG Grim; Ralf Baumeister; Christian Haass
Presenilin-1 differentially facilitates endoproteolysis of the beta-amyloid precursor protein and Notch.
Nature cell biology 2000;2(4):205-11.
1999: Helmut Jacobsen; D Reinhardt; Manfred Brockhaus; Daniel Bur; C Kocyba; H Kurt; MG Grim; Ralf Baumeister; Hansruedi Loetscher
The influence of endoproteolytic processing of familial Alzheimer's disease presenilin 2 on abeta42 amyloid peptide formation.
The Journal of biological chemistry 1999;274(49):35233-9.
1999: Harald Steiner; karen duff; Anja Capell; H Romig; MG Grim; Sarah J Lincoln; John Hardy; X Yu; M Picciano; K Fechteler; Martin Citron; R Kopan; B Pesold; S Keck; Miriam Baader; Taisuke Tomita; Takeshi Iwatsubo; Ralf Baumeister; Christian Haass
A loss of function mutation of presenilin-2 interferes with amyloid beta-peptide production and notch signaling.
The Journal of biological chemistry 1999;274(40):28669-73.
1999: N Wittenburg; Ralf Baumeister
Thermal avoidance in Caenorhabditis elegans: an approach to the study of nociception.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(18):10477-82.
1999: Harald Steiner; H Romig; MG Grim; U Philipp; B Pesold; Martin Citron; Ralf Baumeister; Christian Haass
The biological and pathological function of the presenilin-1 Deltaexon 9 mutation is independent of its defect to undergo proteolytic processing.
The Journal of biological chemistry 1999;274(12):7615-8.
1999: Christian Haass; Ralf Baumeister
The biological and pathological function of presenilin proteins--simple cell systems and a worm in Alzheimer's disease research.
European archives of psychiatry and clinical neuroscience 1999;249 Suppl 3():23-7.
1999: Ralf Baumeister
The physiological role of presenilins in cellular differentiation: lessons from model organisms.
European archives of psychiatry and clinical neuroscience 1999;249(6):280-7.
1998: Manfred Brockhaus; J Grünberg; S Röhrig; Hansruedi Loetscher; N Wittenburg; Ralf Baumeister; Helmut Jacobsen; Christian Haass
Caspase-mediated cleavage is not required for the activity of presenilins in amyloidogenesis and NOTCH signaling.
Neuroreport 1998;9(7):1481-6.
1998: M Loscar; Gustav Schelling; M Haller; J Polasek; Christian Stoll; Uwe Kreimeier; Udilo Finsterer; Heinrich O Steitz; Ralf Baumeister; R Kimmig; Béatrice Grabein; Josef Briegel
Group A streptococcal toxic shock syndrome with severe necrotizing fasciitis following hysterectomy--a case report.
Intensive care medicine 1998;24(2):190-3.
1998: Christian Haass; Ralf Baumeister
What do we learn from a few familial Alzheimer's disease cases?
Journal of neural transmission. Supplementum 1998;54():137-45.
1998: Christian Haass; J Grünberg; Anja Capell; Christine Wild-Bode; U Leimer; Jochen Walter; T Yamazaki; I Ihara; I Zweckbronner; C Jakubek; Ralf Baumeister
Proteolytic processing of Alzheimer's disease associated proteins.
Journal of neural transmission. Supplementum 1998;53():159-67.
1997: Ralf Baumeister; U Leimer; I Zweckbronner; C Jakubek; J Grünberg; Christian Haass
Human presenilin-1, but not familial Alzheimer's disease (FAD) mutants, facilitate Caenorhabditis elegans Notch signalling independently of proteolytic processing.
Genes and function 1997;1(2):149-59.
1996: Ralf Baumeister; Y Liu; Gary Ruvkun
Lineage-specific regulators couple cell lineage asymmetry to the transcription of the Caenorhabditis elegans POU gene unc-86 during neurogenesis.
Genes & development 1996;10(11):1395-410.
1992: Ralf Baumeister; G Müller; B Hecht; Wolfgang Hillen
Functional roles of amino acid residues involved in forming the alpha-helix-turn-alpha-helix operator DNA binding motif of Tet repressor from Tn10.
Proteins 1992;14(2):168-77.
1992: Ralf Baumeister; V Helbl; Wolfgang Hillen
Contacts between Tet repressor and tet operator revealed by new recognition specificities of single amino acid replacement mutants.
Journal of molecular biology 1992;226(4):1257-70.
1992: P Flache; Ralf Baumeister; Wolfgang Hillen
The Tn10-encoded tetracycline resistance mRNA contains a translational silencer in the 5' nontranslated region.
Journal of bacteriology 1992;174(8):2478-84.
1991: A Wissmann; Ralf Baumeister; G Müller; B Hecht; V Helbl; Klaus Pfleiderer; Wolfgang Hillen
Amino acids determining operator binding specificity in the helix-turn-helix motif of Tn10 Tet repressor.
The EMBO journal 1991;10(13):4145-52.
1991: Ralf Baumeister; P Flache; ojar melefors; Alexander von Gabain; Wolfgang Hillen
Lack of a 5' non-coding region in Tn1721 encoded tetR mRNA is associated with a low efficiency of translation and a short half-life in Escherichia coli.
Nucleic acids research 1991;19(17):4595-600.
1991: A Wissmann; L V Wray; U Somaggio; Ralf Baumeister; M Geissendörfer; Wolfgang Hillen
Selection for Tn10 tet repressor binding to tet operator in Escherichia coli: isolation of temperature-sensitive mutants and combinatorial mutagenesis in the DNA binding motif.
Genetics 1991;128(2):225-32.
1988: L Altschmied; Ralf Baumeister; Klaus Pfleiderer; Wolfgang Hillen
A threonine to alanine exchange at position 40 of Tet repressor alters the recognition of the sixth base pair of tet operator from GC to AT.
The EMBO journal 1988;7(12):4011-7.