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Balbino Alarcon

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A Borroto; Elaine P Dopfer; Manuel Fuentes; Alberto Orfao; Marek Prouza; Wolfgang W A Schamel; Miloslav Suchànek; Irene Arellano; Balbino Alarcon
Nck recruitment to the TCR required for ZAP70 activation during thymic development.
Wolfgang W A Schamel; Balbino Alarcon
Organization of the resting TCR in nanoscale oligomers.
Noa B Martín-Cófreces; Alicia Monjas; Balbino Alarcon; Francesc Baixauli; Diana Gil; María J López; Francisco Sánchez-Madrid
End-binding protein 1 controls signal propagation from the T cell receptor.

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2013: A Borroto; Elaine P Dopfer; Manuel Fuentes; Alberto Orfao; Marek Prouza; Wolfgang W A Schamel; Miloslav Suchànek; Irene Arellano; Balbino Alarcon
Nck recruitment to the TCR required for ZAP70 activation during thymic development.
Journal of immunology (Baltimore, Md. : 1950) 2013;190(3):1103-12.
2013: Wolfgang W A Schamel; Balbino Alarcon
Organization of the resting TCR in nanoscale oligomers.
Immunological reviews 2013;251(1):13-20.
2012: Noa B Martín-Cófreces; Alicia Monjas; Balbino Alarcon; Francesc Baixauli; Diana Gil; María J López; Francisco Sánchez-Madrid
End-binding protein 1 controls signal propagation from the T cell receptor.
The EMBO journal 2012;31(21):4140-52.
2012: Romain M Larive; Eugenio Santos; Antonio Abad; Balbino Alarcon; Marta Cañamero; Clara M Cardaba; Enrique de Álava; Teresa Hernández; Xosé R Bustelo
The Ras-like protein R-Ras2/TC21 is important for proper mammary gland development.
Molecular biology of the cell 2012;23(12):2373-87.
2012: Balbino Alarcon; Nuria Martínez-Martín
RRas2, RhoG and T-cell phagocytosis.
Small GTPases 2012;3(2):97-101.
2012: Raquel Blanco; Balbino Alarcon
TCR Nanoclusters as the Framework for Transmission of Conformational Changes and Cooperativity.
Frontiers in immunology 2012;3():115.
2011: Nuria Martínez-Martín; Andrey Shaw; Martin Turner; Xosé R Bustelo; Saso Cemerski; Pilar Delgado; Elena Fernandez-Arenas; John Heuser; Bonnie Huang; Darrell J Irvine; Balbino Alarcon
T cell receptor internalization from the immunological synapse is mediated by TC21 and RhoG GTPase-dependent phagocytosis.
Immunity 2011;35(2):208-22.
2011: Balbino Alarcon; David Mestre; Nuria Martínez-Martín
The immunological synapse: a cause or consequence of T-cell receptor triggering?
Immunology 2011;133(4):420-5.
2011: Salvador Iborra; Manuel Soto; Luiz Stark-Aroeira; Esther Castellano; Balbino Alarcon; Carlos Alonso; Eugenio Santos; Edgar Fernández-Malavé
H-ras and N-ras are dispensable for T-cell development and activation but critical for protective Th1 immunity.
Blood 2011;117(19):5102-11.
2011: Noa B Martín-Cófreces; Balbino Alarcon; Francisco Sánchez-Madrid
Tubulin and actin interplay at the T cell and antigen-presenting cell interface.
Frontiers in immunology 2011;2():24.
2010: Ignacio Arechaga; Mahima Swamy; David Abia; Wolfgang A Schamel; Balbino Alarcon; José María Valpuesta
Structural characterization of the TCR complex by electron microscopy.
International immunology 2010;22(11):897-903.
2010: Balbino Alarcon; Nuria Martínez-Martin
Cytotoxic T cells. Handing over the baton.
Immunology and cell biology 2010;88(5):505-6.
2010: Balbino Alarcon; Hisse M van Santen
Two receptors, two kinases, and T cell lineage determination.
Science signaling 2010;3(114):pe11.
2009: Pilar Delgado; Beatriz Cubelos; Enrique Calleja; Nuria Martínez-Martín; Angel Ciprés; Isabel Mérida; Carmen Bellas; Xosé R Bustelo; Balbino Alarcon
Essential function for the GTPase TC21 in homeostatic antigen receptor signaling.
Nature immunology 2009;10(8):880-8.
2009: Irene Zaldívar; M Angeles Muñoz-Fernández; Balbino Alarcon; Esther San Jose
Expression of a modified form of CD4 results in the release of an anti-HIV factor derived from the Env sequence.
Journal of immunology (Baltimore, Md. : 1950) 2009;183(2):1188-96.
2009: Nuria Martínez-Martín; Ruth M Risueño; Antonio Morreale; Irene Zaldívar; Elena Fernandez-Arenas; Fernando Herranz; Angel R Ortiz; Balbino Alarcon
Cooperativity between T cell receptor complexes revealed by conformational mutants of CD3epsilon.
Science signaling 2009;2(83):ra43.
2009: Clara M Santiveri; Aldo J Borroto; Luis Simón; Manuel Rico; Balbino Alarcon; M Angeles Jiménez
Interaction between the N-terminal SH3 domain of Nck-alpha and CD3-epsilon-derived peptides: non-canonical and canonical recognition motifs.
Biochimica et biophysica acta 2009;1794(1):110-7.
2008: Noa B Martín-Cófreces; Javier Robles-Valero; J Román Cabrero; María Mittelbrunn; Mónica Gordón-Alonso; Ching-Hwa Sung; Balbino Alarcon; Jesús Vázquez; Francisco Sánchez-Madrid
MTOC translocation modulates IS formation and controls sustained T cell signaling.
The Journal of cell biology 2008;182(5):951-62.
2008: Zsolt Sebestyén; Erik Schooten; Tamara Sals; Irene Zaldivar; Esther San Jose; Balbino Alarcon; Sara Bobisse; Antonio Rosato; János Szöllosi; Jan W Gratama; Ralph A Willemsen; Reno Debets
Human TCR that incorporate CD3zeta induce highly preferred pairing between TCRalpha and beta chains following gene transfer.
Journal of immunology (Baltimore, Md. : 1950) 2008;180(11):7736-46.
2008: María J Caloca; Pilar Delgado; Balbino Alarcon; Xose Bustelo
Role of chimaerins, a group of Rac-specific GTPase activating proteins, in T-cell receptor signaling.
Cellular signalling 2008;20(4):758-70.
2008: Susana Minguet; Mahima Swamy; Elaine P Dopfer; Eva Dengler; Balbino Alarcon; Wolfgang W A Schamel
The extracellular part of zeta is buried in the T cell antigen receptor complex.
Immunology letters 2008;116(2):203-10.
2008: Isabel M Olazabal; Noa Beatriz Martín-Cofreces; María Mittelbrunn; Gloria Martínez del Hoyo; Balbino Alarcon; Francisco Sánchez-Madrid
Activation outcomes induced in naïve CD8 T-cells by macrophages primed via "phagocytic" and nonphagocytic pathways.
Molecular biology of the cell 2008;19(2):701-10.
2008: Ruth M Risueño; Angel R Ortiz; Balbino Alarcon
Conformational model.
Advances in experimental medicine and biology 2008;640():103-12.
2008: Ruth M Risueño; Wolfgang W A Schamel; Balbino Alarcon
T cell receptor engagement triggers its CD3epsilon and CD3zeta subunits to adopt a compact, locked conformation.
PloS one 2008;3(3):e1747.
2007: Gabrielle Siegers; Mahima Swamy; Edgar Fernández-Malavé; Susana Minguet; Sylvia Rathmann; Alberto C Guardo; Verónica Pérez-Flores; José R Regueiro; Balbino Alarcon; Paul Fisch; Wolfgang W A Schamel
Different composition of the human and the mouse gammadelta T cell receptor explains different phenotypes of CD3gamma and CD3delta immunodeficiencies.
The Journal of experimental medicine 2007;204(11):2537-44.
2007: Mahima Swamy; Susana Minguet; Gabrielle Siegers; Balbino Alarcon; Wolfgang W A Schamel
A native antibody-based mobility-shift technique (NAMOS-assay) to determine the stoichiometry of multiprotein complexes.
Journal of immunological methods 2007;324(1-2):74-83.
2007: Susana Minguet; Mahima Swamy; Balbino Alarcon; Immanuel F Luescher; Wolfgang W A Schamel
Full activation of the T cell receptor requires both clustering and conformational changes at CD3.
Immunity 2007;26(1):43-54.
2006: Edgar Fernández-Malavé; Ninghai Wang; Manuel Pulgar; Wolfgang W A Schamel; Balbino Alarcon; Cox Terhorst
Overlapping functions of human CD3delta and mouse CD3gamma in alphabeta T-cell development revealed in a humanized CD3gamma-mouse.
Blood 2006;108(10):3420-7.
2006: Ruth M Risueño; Hisse M van Santen; Balbino Alarcon
A conformational change senses the strength of T cell receptor-ligand interaction during thymic selection.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(25):9625-30.
2006: Balbino Alarcon; Mahima Swamy; Hisse M van Santen; Wolfgang W A Schamel
T-cell antigen-receptor stoichiometry: pre-clustering for sensitivity.
EMBO reports 2006;7(5):490-5.
2006: Noa B Martín-Cófreces; David Sancho; Edgar Fernández; Miguel Vicente-Manzanares; Mónica Gordón-Alonso; María C Montoya; Frédérique Michel; Oreste Acuto; Balbino Alarcon; Francisco Sánchez-Madrid
Role of Fyn in the rearrangement of tubulin cytoskeleton induced through TCR.
Journal of immunology (Baltimore, Md. : 1950) 2006;176(7):4201-7.
2006: Wolfgang W A Schamel; Ruth M Risueño; Susana Minguet; Angel R Ortíz; Balbino Alarcon
A conformation- and avidity-based proofreading mechanism for the TCR-CD3 complex.
Trends in immunology 2006;27(4):176-82.
2005: Wolfgang W A Schamel; Ignacio Arechaga; Ruth M Risueño; Hisse M van Santen; Pilar Cabezas; Cristina Risco; José M Valpuesta; Balbino Alarcon
Coexistence of multivalent and monovalent TCRs explains high sensitivity and wide range of response.
The Journal of experimental medicine 2005;202(4):493-503.
2005: Ruth M Risueño; Diana Gil; Edgar Fernández; Francisco Sánchez-Madrid; Balbino Alarcon
Ligand-induced conformational change in the T-cell receptor associated with productive immune synapses.
Blood 2005;106(2):601-8.
2005: Pilar Delgado; Balbino Alarcon
An orderly inactivation of intracellular retention signals controls surface expression of the T cell antigen receptor.
The Journal of experimental medicine 2005;201(4):555-66.
2005: Diana Gil; Adam Schrum; Balbino Alarcon; Ed Palmer
T cell receptor engagement by peptide-MHC ligands induces a conformational change in the CD3 complex of thymocytes.
The Journal of experimental medicine 2005;201(4):517-22.
2004: Alicia Monjas; Andrés Alcover; Balbino Alarcon
Engaged and bystander T cell receptors are down-modulated by different endocytotic pathways.
The Journal of biological chemistry 2004;279(53):55376-84.
2004: David A Zapata; Wolfgang W A Schamel; Pilar S Torres; Balbino Alarcon; Nineth E Rossi; María N Navarro; María L Toribio; José R Regueiro
Biochemical differences in the alphabeta T cell receptor.CD3 surface complex between CD8+ and CD4+ human mature T lymphocytes.
The Journal of biological chemistry 2004;279(23):24485-92.
2003: Balbino Alarcon; Diana Gil; Pilar Delgado; Wolfgang W A Schamel
Initiation of TCR signaling: regulation within CD3 dimers.
Immunological reviews 2003;191():38-46.
2002: David Sancho; María C Montoya; Alicia Monjas; Mónica Gordón-Alonso; Takuya Katagiri; Diana Gil; Reyes Tejedor; Balbino Alarcon; Francisco Sánchez-Madrid
TCR engagement induces proline-rich tyrosine kinase-2 (Pyk2) translocation to the T cell-APC interface independently of Pyk2 activity and in an immunoreceptor tyrosine-based activation motif-mediated fashion.
Journal of immunology (Baltimore, Md. : 1950) 2002;169(1):292-300.
2002: Diana Gil; Wolfgang W A Schamel; María Montoya; Francisco Sánchez-Madrid; Balbino Alarcon
Recruitment of Nck by CD3 epsilon reveals a ligand-induced conformational change essential for T cell receptor signaling and synapse formation.
Cell 2002;109(7):901-12.
2001: D Gil; D Gutiérrez; Balbino Alarcon
Intracellular redistribution of nucleolin upon interaction with the CD3epsilon chain of the T cell receptor complex.
The Journal of biological chemistry 2001;276(14):11174-9.
2000: A Borroto; Diana Gil; Pilar Delgado; Miguel Vicente-Manzanares; Andrés Alcover; Francisco Sánchez-Madrid; Balbino Alarcon
Rho regulates T cell receptor ITAM-induced lymphocyte spreading in an integrin-independent manner.
European journal of immunology 2000;30(12):3403-10.
2000: Pilar Delgado; E Fernández; V Dave; Dietmar J Kappes; Balbino Alarcon
CD3delta couples T-cell receptor signalling to ERK activation and thymocyte positive selection.
Nature 2000;406(6794):426-30.
2000: Esther San Jose; A Borroto; Florence Niedergang; Andrés Alcover; Balbino Alarcon
Triggering the TCR complex causes the downregulation of nonengaged receptors by a signal transduction-dependent mechanism.
Immunity 2000;12(2):161-70.
2000: Andrés Alcover; Balbino Alarcon
Internalization and intracellular fate of TCR-CD3 complexes.
Critical reviews in immunology 2000;20(4):325-46.
1999: David A Zapata; Alberto Pacheco-Castro; Pilar S Torres; Almudena Ramiro; Esther San Jose; Balbino Alarcon; L Alibaud; Bent Rubin; María L Toribio; José R Regueiro
Conformational and biochemical differences in the TCR.CD3 complex of CD8(+) versus CD4(+) mature lymphocytes revealed in the absence of CD3gamma.
The Journal of biological chemistry 1999;274(49):35119-28.
1999: Esther San Jose; Balbino Alarcon
Receptor engagement transiently diverts the T cell receptor heterodimer from a constitutive degradation pathway.
The Journal of biological chemistry 1999;274(47):33740-6.
1999: A Borroto; J Lama; Florence Niedergang; Alice Dautry-Varsat; Balbino Alarcon; Andrés Alcover
The CD3 epsilon subunit of the TCR contains endocytosis signals.
Journal of immunology (Baltimore, Md. : 1950) 1999;163(1):25-31.
1999: Emma Teixeiro; A García-Sahuquillo; Balbino Alarcon; Rafael Bragado
Apoptosis-resistant T cells have a deficiency in NF-kappaB-mediated induction of Fas ligand transcription.
European journal of immunology 1999;29(3):745-54.
1998: Pedro Bonay; I Durán-Chica; Manuel Fresno; Balbino Alarcon; Antonio Alcina
Antiparasitic effects of the intra-Golgi transport inhibitor megalomicin.
Antimicrobial agents and chemotherapy 1998;42(10):2668-73.
1998: Esther San Jose; M Angeles Muñoz-Fernández; Balbino Alarcon
Retroviral vector-mediated expression in primary human T cells of an endoplasmic reticulum-retained CD4 chimera inhibits human immunodeficiency virus type-1 replication.
Human gene therapy 1998;9(9):1345-57.
1998: A Borroto; A Mallabiabarrena; Juan Pablo Albar; Carlos Martínez-A; Balbino Alarcon
Characterization of the region involved in CD3 pairwise interactions within the T cell receptor complex.
The Journal of biological chemistry 1998;273(21):12807-16.
1998: A G Sahuquillo; Anne Roumier; Emma Teixeiro; Rafael Bragado; Balbino Alarcon
T cell receptor (TCR) engagement in apoptosis-defective, but interleukin 2 (IL-2)-producing, T cells results in impaired ZAP70/CD3-zeta association.
The Journal of experimental medicine 1998;187(8):1179-92.
1998: Esther San Jose; A G Sahuquillo; Rafael Bragado; Balbino Alarcon
Assembly of the TCR/CD3 complex: CD3 epsilon/delta and CD3 epsilon/gamma dimers associate indistinctly with both TCR alpha and TCR beta chains. Evidence for a double TCR heterodimer model.
European journal of immunology 1998;28(1):12-21.
1997: Esther San Jose; M Angeles Muñoz-Fernández; Balbino Alarcon
Megalomicin inhibits HIV-1 replication and interferes with gp160 processing.
Virology 1997;239(2):303-14.
1997: Miguel A Alonso; L Fan; Balbino Alarcon
Multiple sorting signals determine apical localization of a nonglycosylated integral membrane protein.
The Journal of biological chemistry 1997;272(49):30748-52.
1997: Pedro Bonay; Manuel Fresno; Balbino Alarcon
Megalomicin disrupts lysosomal functions.
Journal of cell science 1997;110 ( Pt 16)():1839-49.
1997: Florence Niedergang; Esther San Jose; Bent Rubin; Balbino Alarcon; Alice Dautry-Varsat; Andrés Alcover
Differential cytosolic tail dependence and intracellular fate of T-cell receptors internalized upon activation with superantigen or phorbol ester.
Research in immunology 1997;148(4):231-45.
1997: A Borroto; M A Jiménez; Balbino Alarcon; M Rico
1H-NMR analysis of CD3-epsilon reveals the presence of turn-helix structures around the ITAM motif in an otherwise random coil cytoplasmic tail.
Biopolymers 1997;42(1):75-88.
1996: G Rodríguez-Tarduchy; A G Sahuquillo; Balbino Alarcon; Rafael Bragado
Apoptosis but not other activation events is inhibited by a mutation in the transmembrane domain of T cell receptor beta that impairs CD3zeta association.
The Journal of biological chemistry 1996;271(48):30417-25.
1996: Pedro Bonay; S Munro; Manuel Fresno; Balbino Alarcon
Intra-Golgi transport inhibition by megalomicin.
The Journal of biological chemistry 1996;271(7):3719-26.
1995: Dietmar J Kappes; Balbino Alarcon; José R Regueiro
T lymphocyte receptor deficiencies.
Current opinion in immunology 1995;7(4):441-7.
1995: A Mallabiabarrena; M A Jiménez; M Rico; Balbino Alarcon
A tyrosine-containing motif mediates ER retention of CD3-epsilon and adopts a helix-turn structure.
The EMBO journal 1995;14(10):2257-68.
1995: A Salmerón; A Borroto; Manuel Fresno; M J Crumpton; Steven C Ley; Balbino Alarcon
Transferrin receptor induces tyrosine phosphorylation in T cells and is physically associated with the TCR zeta-chain.
Journal of immunology (Baltimore, Md. : 1950) 1995;154(4):1675-83.
1992: A Mallabiabarrena; Manuel Fresno; Balbino Alarcon
An endoplasmic reticulum retention signal in the CD3 epsilon chain of the T-cell receptor.
Nature 1992;357(6379):593-6.
1991: A Salmerón; Francisco Sánchez-Madrid; M A Ursa; Manuel Fresno; Balbino Alarcon
A conformational epitope expressed upon association of CD3-epsilon with either CD3-delta or CD3-gamma is the main target for recognition by anti-CD3 monoclonal antibodies.
Journal of immunology (Baltimore, Md. : 1950) 1991;147(9):3047-52.
1991: P Pérez-Aciego; Balbino Alarcon; Antonio Arnaiz-Villena; C Terhorst; M Timón; Oscar Segurado; José R Regueiro
Expression and function of a variant T cell receptor complex lacking CD3-gamma.
The Journal of experimental medicine 1991;174(2):319-26.
1991: Balbino Alarcon; Steven C Ley; F Sánchez-Madrid; Richard S Blumberg; S T Ju; Manuel Fresno; Cox Terhorst
The CD3-gamma and CD3-delta subunits of the T cell antigen receptor can be expressed within distinct functional TCR/CD3 complexes.
The EMBO journal 1991;10(4):903-12.
1989: J A Lopez Guerrero; Juan Miguel Redondo; Balbino Alarcon; Francisco Sánchez-Madrid; M Rodríguez Moya; M Ortíz de Landazuri; Carmelo Bernabeu; Manuel Fresno
Different functional domains on the transferrin receptor molecule defined by monoclonal antibodies.
Immunology 1989;66(2):252-7.
1988: J A López-Guerrero; Balbino Alarcon; Manuel Fresno
Mechanism of recognition of herpes simplex virus type 1-infected cells by natural killer cells.
The Journal of general virology 1988;69 ( Pt 11)():2859-68.
1988: Antonio Alcina; Manuel Fresno; Balbino Alarcon
Activity of P536, a UDP-glucose analog, against Trypanosoma cruzi.
Antimicrobial agents and chemotherapy 1988;32(9):1412-5.
1988: Balbino Alarcon; Maria Eugenia González; Luis Carrasco; P P Méndez-Castrillón; M Teresa García-López; F G de las Heras
Mode of action of a new type of UDP-glucose analog against herpesvirus replication.
Antimicrobial agents and chemotherapy 1988;32(8):1257-61.
1988: Balbino Alarcon; Maria Eugenia González; Luis Carrasco
Megalomycin C, a macrolide antibiotic that blocks protein glycosylation and shows antiviral activity.
FEBS letters 1988;231(1):207-11.
1988: Balbino Alarcon; Juan Miguel Redondo; H Bugany; L Carrasco; Manuel Fresno
Inhibition of natural killer cytotoxicity by extracellular ppp(A2'p5')nA oligonucleotides.
International journal of immunopharmacology 1988;10(1):73-80.
1987: Maria Eugenia González; Balbino Alarcon; Luis Carrasco
Polysaccharides as antiviral agents: antiviral activity of carrageenan.
Antimicrobial agents and chemotherapy 1987;31(9):1388-93.
1986: A Sola; S Rodríguez; C Gil-Fernández; Balbino Alarcon; Maria Eugenia González; Luis Carrasco
New agents active against African swine fever virus.
Antimicrobial agents and chemotherapy 1986;29(2):284-8.
1985: R Alonso; J I Andrés; M Teresa García-López; F G de las Heras; Rosario Herranz; Balbino Alarcon; Luis Carrasco
Synthesis and antiviral evaluation of nucleosides of 5-methylimidazole-4-carboxamide.
Journal of medicinal chemistry 1985;28(6):834-8.
1985: M J Camarasa; P Fernández-Resa; M T Garcia-López; F G De las Heras; P P Méndez-Castrillón; Balbino Alarcon; Luis Carrasco
Uridine 5'-diphosphate glucose analogues. Inhibitors of protein glycosylation that show antiviral activity.
Journal of medicinal chemistry 1985;28(1):40-6.
1984: Balbino Alarcon; Maria Eugenia González; Luis Carrasco
Antiherpesvirus action of atropine.
Antimicrobial agents and chemotherapy 1984;26(5):702-6.