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Tim D. Sparwasser

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Ilseyar Akhmetzyanova; Petra Altenhoff; Sven Brandau; Simone Schimmer; Tim D. Sparwasser; Gennadiy Zelinskyy; Ulf Dittmer
Tumor-specific CD4+ T cells develop cytotoxic activity and eliminate virus-induced tumor cells in the absence of regulatory T cells.
Christoph Kleinschnitz; Peter Kraft; Friederike Langhauser; Tim Magnus; Christian T Mayer; Sven G Meuth; Bernhard Nieswandt; Mirko Pham; Michael K Schuhmann; Tobias Schwarz; Tim D. Sparwasser; Guido Stoll; Csanad Varallyay; Martin Bendszus; Stefan Bittner; Marc Brede; Angela Dreykluft; Kerstin Göbel; Ina Hagedorn; Xavier Helluy; Yoichiro Iwakura; Peter Jakob; Alma Zernecke; Heinz Wiendl
Regulatory T cells are strong promoters of acute ischemic stroke in mice by inducing dysfunction of the cerebral microvasculature.
Marc Schuster; Britta Siegmund; Tim D. Sparwasser; Lisa Schreiber; Klaus Schulze-Osthoff; Michaela Annemann; Linda K Clayton; Stefan Floess; Rainer Glauben; Jochen Huehn; Anja A Kühl; Klaus Pfeffer; Carlos Plaza-Sirvent; Ingo Schmitz
IκB(NS) protein mediates regulatory T cell development via induction of the Foxp3 transcription factor.

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All Publications

2013: Ilseyar Akhmetzyanova; Petra Altenhoff; Sven Brandau; Simone Schimmer; Tim D. Sparwasser; Gennadiy Zelinskyy; Ulf Dittmer
Tumor-specific CD4+ T cells develop cytotoxic activity and eliminate virus-induced tumor cells in the absence of regulatory T cells.
Cancer immunology, immunotherapy : CII 2013;62(2):257-71.
2013: Christoph Kleinschnitz; Peter Kraft; Friederike Langhauser; Tim Magnus; Christian T Mayer; Sven G Meuth; Bernhard Nieswandt; Mirko Pham; Michael K Schuhmann; Tobias Schwarz; Tim D. Sparwasser; Guido Stoll; Csanad Varallyay; Martin Bendszus; Stefan Bittner; Marc Brede; Angela Dreykluft; Kerstin Göbel; Ina Hagedorn; Xavier Helluy; Yoichiro Iwakura; Peter Jakob; Alma Zernecke; Heinz Wiendl
Regulatory T cells are strong promoters of acute ischemic stroke in mice by inducing dysfunction of the cerebral microvasculature.
Blood 2013;121(4):679-91.
2012: Marc Schuster; Britta Siegmund; Tim D. Sparwasser; Lisa Schreiber; Klaus Schulze-Osthoff; Michaela Annemann; Linda K Clayton; Stefan Floess; Rainer Glauben; Jochen Huehn; Anja A Kühl; Klaus Pfeffer; Carlos Plaza-Sirvent; Ingo Schmitz
IκB(NS) protein mediates regulatory T cell development via induction of the Foxp3 transcription factor.
Immunity 2012;37(6):998-1008.
2012: Agatha Schwarz; Björn E Clausen; Fatemeh Navid; Tim D. Sparwasser; Thomas Schwarz
1,25-dihydroxyvitamin D exerts similar immunosuppressive effects as UVR but is dispensable for local UVR-induced immunosuppression.
The Journal of investigative dermatology 2012;132(12):2762-9.
2012: Sari Lehtimäki; Terhi Savinko; Tim D. Sparwasser; Henrik Wolff; Harri Alenius; Katharina Lahl; Antti Lauerma; N Fyhrquist
The temporal and spatial dynamics of Foxp3+ Treg cell-mediated suppression during contact hypersensitivity responses in a murine model.
The Journal of investigative dermatology 2012;132(12):2744-51.
2012: Luigia Pace; Tim D. Sparwasser; Andy Tempez; Catharina Arnold-Schrauf; Philippe Bousso; Luc Fetler; Fabrice Lemaitre; Sebastian Amigorena
Regulatory T cells increase the avidity of primary CD8+ T cell responses and promote memory.
Science (New York, N.Y.) 2012;338(6106):532-6.
2012: Wiebke Hansen; Simone Abel; Juliane Albert; Christina Alter; Jan Buer; Marina Hutzler; Stefanie Kliche; Shimon Sakaguchi; Dirk Schadendorf; Tim D. Sparwasser; Christian Stockmann; Astrid M Westendorf; Iris Helfrich
Neuropilin 1 deficiency on CD4+Foxp3+ regulatory T cells impairs mouse melanoma growth.
The Journal of experimental medicine 2012;209(11):2001-16.
2012: Matteo Auriemma; Thomas Brzoska; Tobias Goerge; Lars Klenner; Verena Kupas; Thomas A Luger; Tim D. Sparwasser; Maik Voskort; Zuotao Zhao; Karin Loser
α-MSH-stimulated tolerogenic dendritic cells induce functional regulatory T cells and ameliorate ongoing skin inflammation.
The Journal of investigative dermatology 2012;132(7):1814-24.
2012: Renee J Robb; Tim D. Sparwasser; Bianca E Teal; Antiopi Varelias; Yana A Wilson; Kate A Markey; Stuart Olver; Neil C Raffelt; Kylie A Alexander; Andrew D Clouston; Christian R Engwerda; Gunter J Hammerling; Geoffrey R Hill; Motoko Koyama; Rachel D Kuns; Katie E Lineburg; Kelli P A MacDonald
Identification and expansion of highly suppressive CD8(+)FoxP3(+) regulatory T cells after experimental allogeneic bone marrow transplantation.
Blood 2012;119(24):5898-908.
2012: Simone Abel; Jan Buer; Robert Geffers; Nadja Lückheide; Kai Matuschewski; Werner Müller; Axel Roers; Tim D. Sparwasser; Astrid M Westendorf; Wiebke Hansen
Strong impact of CD4+ Foxp3+ regulatory T cells and limited effect of T cell-derived IL-10 on pathogen clearance during Plasmodium yoelii infection.
Journal of immunology (Baltimore, Md. : 1950) 2012;188(11):5467-77.
2012: N Fyhrquist; Katharina Lahl; Anna-Mari Lappeteläinen; Antti Lauerma; Sari Lehtimäki; Terhi Savinko; Tim D. Sparwasser; Henrik Wolff; Harri Alenius
Foxp3+ cells control Th2 responses in a murine model of atopic dermatitis.
The Journal of investigative dermatology 2012;132(6):1672-80.
2012: Mercedes Gomez de Agüero; Fériel Hacini-Rachinel; Dominique Kaiserlian; adrien kissenpfennig; Bernard Malissen; Tim D. Sparwasser; Morgan Taillardet; Marc Vocanson; Bertrand Dubois
Langerhans cells protect from allergic contact dermatitis in mice by tolerizing CD8(+) T cells and activating Foxp3(+) regulatory T cells.
The Journal of clinical investigation 2012;122(5):1700-11.
2012: Luisa Cervantes-Barragán; Sonja Firner; Katharina Lahl; Tim D. Sparwasser; Volker Thiel; Ari Waisman; Ingo Bechmann; Burkhard Ludewig
Regulatory T cells selectively preserve immune privilege of self-antigens during viral central nervous system infection.
Journal of immunology (Baltimore, Md. : 1950) 2012;188(8):3678-85.
2012: J Loebbermann; Fiona J Culley; Lydia Durant; C Johansson; Tim D. Sparwasser; J Sprent; H Thornton; K E Webster; Peter J M Openshaw
Regulatory T cells expressing granzyme B play a critical role in controlling lung inflammation during acute viral infection.
Mucosal immunology 2012;5(2):161-72.
2012: Luciana Berod; Jochen Huehn; Franz Puttur; Tim D. Sparwasser
Tregs in infection and vaccinology: heroes or traitors?
Microbial biotechnology 2012;5(2):260-9.
2012: Christian T Mayer; Anja A Kühl; Christoph Loddenkemper; Tim D. Sparwasser
Lack of Foxp3+ macrophages in both untreated and B16 melanoma-bearing mice.
Blood 2012;119(5):1314-5.
2012: Jens Eberlein; Tom T Nguyen; Tim D. Sparwasser; Francisco Victorino; Bennett Davenport; Dirk Homann
Multiple layers of CD80/86-dependent costimulatory activity regulate primary, memory, and secondary lymphocytic choriomeningitis virus-specific T cell immunity.
Journal of virology 2012;86(4):1955-70.
2012: A A Hellingman; Maarten A Lijkwan; A J N M Bastiaansen; Jaap F Hamming; H H Smits; Tim D. Sparwasser; L E P M van der Vlugt; P H A Quax
A limited role for regulatory T cells in post-ischemic neovascularization.
Journal of cellular and molecular medicine 2012;16(2):328-36.
2012: Fatemeh Navid; Werner Müller; Thomas Schwarz; Ehrhardt Proksch; Tim D. Sparwasser; Catherine Walker; Michele Boniotto; Kerstin Ahrens; Agatha Schwarz
Induction of regulatory T cells by a murine β-defensin.
Journal of immunology (Baltimore, Md. : 1950) 2012;188(2):735-43.
2012: Marc Panzer; Ingo Drexler; Tim D. Sparwasser; Selina Sitte; Stefanie Wirth; David Voehringer
Rapid in vivo conversion of effector T cells into Th2 cells during helminth infection.
Journal of immunology (Baltimore, Md. : 1950) 2012;188(2):615-23.
2012: Abdul Mannan Baru; Georg Behrens; Venkateswaran Ganesh; Silke Glage; Christina Hesse; Jayendra Kumar Krishnaswamy; Christian Thomas Mayer; Franz Puttur; Christopher Untucht; Tim D. Sparwasser
Absence of Foxp3+ regulatory T cells during allergen provocation does not exacerbate murine allergic airway inflammation.
PloS one 2012;7(10):e47102.
2012: Abdul Mannan Baru; Venkateswaran Ganesh; Christina Hesse; Christian T Mayer; Christopher Untucht; Tim D. Sparwasser
Optimal isolation of functional Foxp3+ induced regulatory T cells using DEREG mice.
PloS one 2012;7(9):e44760.
2012: Christian T Mayer; Luciana Berod; Tim D. Sparwasser
Layers of dendritic cell-mediated T cell tolerance, their regulation and the prevention of autoimmunity.
Frontiers in immunology 2012;3():183.
2012: Dajana Reuter; Thomas Hünig; Tim D. Sparwasser; Jürgen Schneider-Schaulies
Foxp3+ regulatory T cells control persistence of viral CNS infection.
PloS one 2012;7(3):e33989.
2012: Luciën E P M van der Vlugt; Maria Yazdanbakhsh; Tim D. Sparwasser; Ayola A Adegnika; Tom A Barr; Louis Boon; Eliane Ngoune Feugap; Anouk K Gloudemans; David Gray; Peter G Kremsner; Lucja A Labuda; Ellen Lievers; Kit-Yeng Liu; Ulysse Ateba Ngoa; Arifa Ozir-Fazalalikhan; Hermelijn H Smits
Schistosomes induce regulatory features in human and mouse CD1d(hi) B cells: inhibition of allergic inflammation by IL-10 and regulatory T cells.
PloS one 2012;7(2):e30883.
2011: Barbara Cassani; Adam Lacy-Hulbert; Paul E Love; Francisco J Quintana; Scott B Snapper; Tim D. Sparwasser; Eduardo J Villablanca; Howard L Weiner; William S Blaner; J Rodrigo Mora
Gut-tropic T cells that express integrin α4β7 and CCR9 are required for induction of oral immune tolerance in mice.
Gastroenterology 2011;141(6):2109-18.
2011: Sandra Lo Re; Yousof Yakoub; Dominique Lison; Francine Uwambayinema; Jean-Baptiste Demoulin; Jean-Christophe Renauld; Sophie Lucas; Marylène Lecocq; Monique Delos; Tim D. Sparwasser; François Huaux
Platelet-derived growth factor-producing CD4+ Foxp3+ regulatory T lymphocytes promote lung fibrosis.
American journal of respiratory and critical care medicine 2011;184(11):1270-81.
2011: Christoph Wilhelm; Mauro Tolaini; Jacques Van Snick; Helena Helmby; Keiji Hirota; Katharina Lahl; Tim D. Sparwasser; Benjamin Stieglitz; Brigitta Stockinger
An IL-9 fate reporter demonstrates the induction of an innate IL-9 response in lung inflammation.
Nature immunology 2011;12(11):1071-7.
2011: Paul J Tacken; Luciana Berod; Luis J Cruz; Carl G Figdor; Wiebke Ginter; Ben Joosten; Tim D. Sparwasser; Alessandra Cambi
Targeting DC-SIGN via its neck region leads to prolonged antigen residence in early endosomes, delayed lysosomal degradation, and cross-presentation.
Blood 2011;118(15):4111-9.
2011: Agatha Schwarz; Björn E Clausen; Fatemeh Navid; Tim D. Sparwasser; Thomas Schwarz
In vivo reprogramming of UV radiation-induced regulatory T-cell migration to inhibit the elicitation of contact hypersensitivity.
The Journal of allergy and clinical immunology 2011;128(4):826-33.
2011: Wolfgang Kastenmuller; Tim D. Sparwasser; Naeha Subramanian; Yasmine Belkaid; Dirk H Busch; Ingo Drexler; Georg Gasteiger; Ronald N Germain
Regulatory T cells selectively control CD8+ T cell effector pool size via IL-2 restriction.
Journal of immunology (Baltimore, Md. : 1950) 2011;187(6):3186-97.
2011: Marc Beyer; Bruce R Blazar; Jeffrey A Bluestone; Jan Böttcher; Sabine Classen; Svenja Debey-Pascher; Elmar Endl; Michael Famulok; Tatiana Golovina; Keli L Hippen; Andrea Hofmann; Percy A Knolle; Waldemar Kolanus; Wolfgang Krebs; Katharina Lahl; Andreas Limmer; Christian T Mayer; Günter Mayer; Roman-Ulrich Müller; Thomas Quast; James L Riley; Timothy Sadlon; Bernhard Schermer; Eva A Schönfeld; Samantha L Bailey-Bucktrout; Robert Balderas; Simon C Barry; Samik Basu; Daniel Sommer; Tim D. Sparwasser; Yasser Thabet; Andreas Waha; Claudia Wickenhauser; Xuyu Zhou; Joachim L Schultze
Repression of the genome organizer SATB1 in regulatory T cells is required for suppressive function and inhibition of effector differentiation.
Nature immunology 2011;12(9):898-907.
2011: Eva-Maria Weiss; Natalio Garbi; Katharina Lahl; Andreas Ludwig; Christian T Mayer; Nina Oberle; Angelika Schmidt; Tim D. Sparwasser; Elisabeth Suri-Payer; Diana Vobis; Peter H Krammer
Foxp3-mediated suppression of CD95L expression confers resistance to activation-induced cell death in regulatory T cells.
Journal of immunology (Baltimore, Md. : 1950) 2011;187(4):1684-91.
2011: Aurélie Olivier; Alexander Sainz-Perez; Tim D. Sparwasser; Hui Dong; Laleh Majlessi; Claude Leclerc
The adjuvant effect of TLR agonists on CD4(+) effector T cells is under the indirect control of regulatory T cells.
European journal of immunology 2011;41(8):2303-13.
2011: Norman Woller; Lars Zender; Bita Boozari; Engin Gürlevik; Arnold Kloos; Sarah Knocke; Stefan Kubicka; Nisar P Malek; Michael P Manns; Bettina Mundt; Peter Schache; Tim D. Sparwasser; Nina Strüver; Thomas C Wirth; Florian Kühnel
Virus-induced tumor inflammation facilitates effective DC cancer immunotherapy in a Treg-dependent manner in mice.
The Journal of clinical investigation 2011;121(7):2570-82.
2011: Hans-Joachim Paust; Tim D. Sparwasser; Jan-Eric Turner; Joachim Velden; Annette Erhardt; Hans-Willi Mittrücker; Annett Ostmann; Ulf Panzer; Gisa Tiegs
Regulatory T cells control the Th1 immune response in murine crescentic glomerulonephritis.
Kidney international 2011;80(2):154-64.
2011: Edward Seung; Tim D. Sparwasser; Josalyn L Cho; Benjamin D Medoff; Andrew D Luster
Inhibiting CXCR3-dependent CD8+ T cell trafficking enhances tolerance induction in a mouse model of lung rejection.
Journal of immunology (Baltimore, Md. : 1950) 2011;186(12):6830-8.
2011: Alice McNally; Geoffrey R Hill; Tim D. Sparwasser; Ranjeny Thomas; Raymond J Steptoe
CD4+CD25+ regulatory T cells control CD8+ T-cell effector differentiation by modulating IL-2 homeostasis.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(18):7529-34.
2011: Karen Wheeler; Steve Tardif; Claudia Rival; Brian Luu; Elise Bui; Roxana Del Rio; Cory Teuscher; Tim D. Sparwasser; Daniel Hardy; Kenneth S K Tung
Regulatory T cells control tolerogenic versus autoimmune response to sperm in vasectomy.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(18):7511-6.
2011: Daniela Hackl; Jakob Loschko; Tim D. Sparwasser; Wolfgang Reindl; Anne Krug
Activation of dendritic cells via TLR7 reduces Foxp3 expression and suppressive function in induced Tregs.
European journal of immunology 2011;41(5):1334-43.
2011: John Stagg; Upulie Divisekera; Helene Duret; Tim D. Sparwasser; Michele W L Teng; Phillip K Darcy; Mark J Smyth
CD73-deficient mice have increased antitumor immunity and are resistant to experimental metastasis.
Cancer research 2011;71(8):2892-900.
2011: Birte Blankenhaus; Ulrike Klemm; Marie-Luise Eschbach; Tim D. Sparwasser; Jochen Huehn; Anja A Kühl; Christoph Loddenkemper; Thomas Jacobs; Minka Breloer
Strongyloides ratti infection induces expansion of Foxp3+ regulatory T cells that interfere with immune response and parasite clearance in BALB/c mice.
Journal of immunology (Baltimore, Md. : 1950) 2011;186(7):4295-305.
2011: Christian T Mayer; Stefan Floess; Abdul Mannan Baru; Katharina Lahl; Jochen Huehn; Tim D. Sparwasser
CD8+ Foxp3+ T cells share developmental and phenotypic features with classical CD4+ Foxp3+ regulatory T cells but lack potent suppressive activity.
European journal of immunology 2011;41(3):716-25.
2011: Usriansyah Hadis; Benjamin Wahl; Olga Schulz; Matthias Hardtke-Wolenski; Angela Schippers; Norbert Wagner; Werner Muller; Tim D. Sparwasser; Reinhold Förster; Oliver Pabst
Intestinal tolerance requires gut homing and expansion of FoxP3+ regulatory T cells in the lamina propria.
Immunity 2011;34(2):237-46.
2011: Marc Pellegrini; Thomas Calzascia; Jesse G Toe; Simon P Preston; Amy E Lin; Alisha R Elford; Arda Shahinian; Philipp A Lang; Karl S Lang; Michel MORRE; Brigitte Assouline; Katharina Lahl; Tim D. Sparwasser; Thomas F Tedder; Ji-Hye Paik; Ronald A DePinho; Sameh Basta; Pamela S Ohashi; Tak W Mak
IL-7 engages multiple mechanisms to overcome chronic viral infection and limit organ pathology.
Cell 2011;144(4):601-13.
2011: Kirsten K Dietze; Gennadiy Zelinskyy; Kathrin Gibbert; Simone Schimmer; Sandra Francois; Lara Myers; Tim D. Sparwasser; Kim J Hasenkrug; Ulf Dittmer
Transient depletion of regulatory T cells in transgenic mice reactivates virus-specific CD8+ T cells and reduces chronic retroviral set points.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(6):2420-5.
2011: Martin Vaeth; Tea Gogishvili; Tobias Bopp; Matthias Klein; Friederike Berberich-Siebelt; Stefan Gattenloehner; Andris Avots; Tim D. Sparwasser; Nadine Grebe; Edgar Schmitt; Thomas Hünig; Edgar Serfling; Josef Bodor
Regulatory T cells facilitate the nuclear accumulation of inducible cAMP early repressor (ICER) and suppress nuclear factor of activated T cell c1 (NFATc1).
Proceedings of the National Academy of Sciences of the United States of America 2011;108(6):2480-5.
2011: Lucas Onder; Thomas Rülicke; Elke Scandella; Tim D. Sparwasser; Volker Thiel; Qian Chai; Sonja Firner; Christian T Mayer; Burkhard Ludewig
A novel bacterial artificial chromosome-transgenic podoplanin-cre mouse targets lymphoid organ stromal cells in vivo.
Frontiers in immunology 2011;2():50.
2011: Katharina Lahl; Tim D. Sparwasser
In vivo depletion of FoxP3+ Tregs using the DEREG mouse model.
Methods in molecular biology (Clifton, N.J.) 2011;707():157-72.
2011: S Navarro; G Cossalter; C Chiavaroli; A Kanda; S Fleury; A Lazzari; Julie Cazareth; Tim D. Sparwasser; D Dombrowicz; Nicolas Glaichenhaus; Valerie Julia
The oral administration of bacterial extracts prevents asthma via the recruitment of regulatory T cells to the airways.
Mucosal immunology 2011;4(1):53-65.
2011: Isabelle C Arnold; Josephine Y Lee; Manuel R Amieva; Axel Roers; Richard A Flavell; Tim D. Sparwasser; Anne Müller
Tolerance rather than immunity protects from Helicobacter pylori-induced gastric preneoplasia.
Gastroenterology 2011;140(1):199-209.
2010: Daniel R Engel; Arne Koscielny; Sven Wehner; Juliane Maurer; Marzena Schiwon; Lars Franken; Beatrix Schumak; Andreas Limmer; Tim D. Sparwasser; Andreas Hirner; Percy A Knolle; Jörg C Kalff; Christian Kurts
T helper type 1 memory cells disseminate postoperative ileus over the entire intestinal tract.
Nature medicine 2010;16(12):1407-13.
2010: Sandra Hubert; Björn Rissiek; Katjana Klages; Jochen Huehn; Tim D. Sparwasser; Friedrich Haag; Friedrich Koch-Nolte; Olivier Boyer; Michel Seman; Sahil Adriouch
Extracellular NAD+ shapes the Foxp3+ regulatory T cell compartment through the ART2-P2X7 pathway.
The Journal of experimental medicine 2010;207(12):2561-8.
2010: Michele W L Teng; Shin Foong Ngiow; Bianca von Scheidt; Nicole McLaughlin; Tim D. Sparwasser; Mark J Smyth
Conditional regulatory T-cell depletion releases adaptive immunity preventing carcinogenesis and suppressing established tumor growth.
Cancer research 2010;70(20):7800-9.
2010: Katjana Klages; Christian T Mayer; Katharina Lahl; Christoph Loddenkemper; Michele W L Teng; Shin Foong Ngiow; Mark J Smyth; Alf Hamann; Jochen Huehn; Tim D. Sparwasser
Selective depletion of Foxp3+ regulatory T cells improves effective therapeutic vaccination against established melanoma.
Cancer research 2010;70(20):7788-99.
2010: Abdul Mannan Baru; Andrea Hartl; Katharina Lahl; Jayendra Kumar Krishnaswamy; Heinz Fehrenbach; Ali O Yildirim; Holger Garn; Harald Renz; Georg M N Behrens; Tim D. Sparwasser
Selective depletion of Foxp3+ Treg during sensitization phase aggravates experimental allergic airway inflammation.
European journal of immunology 2010;40(8):2259-66.
2010: Svetlana Hamm; Eicke Latz; Doris Hangel; Thomas Müller; Philipp Yu; Douglas Golenbock; Tim D. Sparwasser; Hermann Wagner; Stefan Bauer
Alternating 2'-O-ribose methylation is a universal approach for generating non-stimulatory siRNA by acting as TLR7 antagonist.
Immunobiology 2010;215(7):559-69.
2010: Kathrin Suttner; Martin Depner; Martin Wetzke; Norman Klopp; Erika von Mutius; Thomas Illig; Tim D. Sparwasser; Michael Kabesch
Genetic variants harbored in the forkhead box protein 3 locus increase hay fever risk.
The Journal of allergy and clinical immunology 2010;125(6):1395-9.
2010: Konstanze Pechloff; Julian Holch; Uta Ferch; Marc Schweneker; Kristina Brunner; Markus Kremer; Tim D. Sparwasser; Leticia Quintanilla-Martinez; Ursula Zimber-Strobl; Berthold Streubel; Andreas Gewies; Christian Peschel; Jürgen Ruland
The fusion kinase ITK-SYK mimics a T cell receptor signal and drives oncogenesis in conditional mouse models of peripheral T cell lymphoma.
The Journal of experimental medicine 2010;207(5):1031-44.
2010: Alexandre Boissonnas; Alix Scholer-Dahirel; Virginie Simon-Blancal; Luigia Pace; Fabien Valet; adrien kissenpfennig; Tim D. Sparwasser; Bernard Malissen; Luc Fetler; Sebastian Amigorena
Foxp3+ T cells induce perforin-dependent dendritic cell death in tumor-draining lymph nodes.
Immunity 2010;32(2):266-78.
2010: David Anz; Viktor H Koelzer; Stefan Moder; Raffael Thaler; Tobias Schwerd; Katharina Lahl; Tim D. Sparwasser; Robert Besch; Hendrik Poeck; Veit Hornung; Gunther Hartmann; Simon Rothenfusser; Carole Bourquin; Stefan Endres
Immunostimulatory RNA blocks suppression by regulatory T cells.
Journal of immunology (Baltimore, Md. : 1950) 2010;184(2):939-46.
2010: Anita Schildknecht; Sabine Brauer; Corinne Brenner; Katharina Lahl; Hansjörg Schild; Tim D. Sparwasser; Hans Christian Probst; Maries van den Broek
FoxP3+ regulatory T cells essentially contribute to peripheral CD8+ T-cell tolerance induced by steady-state dendritic cells.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(1):199-203.
2010: Ashraful Haque; Shannon E Best; Fiona H Amante; Seri Mustafah; Laure Desbarrieres; Fabian de Labastida; Tim D. Sparwasser; Geoffrey R Hill; Christian R Engwerda
CD4+ natural regulatory T cells prevent experimental cerebral malaria via CTLA-4 when expanded in vivo.
PLoS pathogens 2010;6(12):e1001221.
2009: Jeong Kim; Katharina Lahl; Shohei Hori; Christoph Loddenkemper; Ashutosh Chaudhry; Paul deRoos; Alexander Y Rudensky; Tim D. Sparwasser
Cutting edge: depletion of Foxp3+ cells leads to induction of autoimmunity by specific ablation of regulatory T cells in genetically targeted mice.
Journal of immunology (Baltimore, Md. : 1950) 2009;183(12):7631-4.
2009: Christiane Steeg; Guido Adler; Tim D. Sparwasser; Bernhard Fleischer; Thomas Jacobs
Limited role of CD4+Foxp3+ regulatory T cells in the control of experimental cerebral malaria.
Journal of immunology (Baltimore, Md. : 1950) 2009;183(11):7014-22.
2009: Satwinder Kaur Singh; Johannes Stephani; Martin Schaefer; Hakan Kalay; Juan Jesus Garcia Vallejo; Joke M M den Haan; Eirikur Saeland; Tim D. Sparwasser; Yvette van Kooyk
Targeting glycan modified OVA to murine DC-SIGN transgenic dendritic cells enhances MHC class I and II presentation.
Molecular immunology 2009;47(2-3):164-74.
2009: Katharina Lahl; Christian T Mayer; Tobias Bopp; Jochen Huehn; Christoph Loddenkemper; Gérard Eberl; Gerald Wirnsberger; Klaus Dornmair; Robert Geffers; Edgar Schmitt; Jan Buer; Tim D. Sparwasser
Nonfunctional regulatory T cells and defective control of Th2 cytokine production in natural scurfy mutant mice.
Journal of immunology (Baltimore, Md. : 1950) 2009;183(9):5662-72.
2009: Sebastian Rausch; Jochen Huehn; Christoph Loddenkemper; Matthew R Hepworth; Christian Klotz; Tim D. Sparwasser; Alf Hamann; Richard Lucius; Susanne Hartmann
Establishment of nematode infection despite increased Th2 responses and immunopathology after selective depletion of Foxp3+ cells.
European journal of immunology 2009;39(11):3066-77.
2009: Gennadiy Zelinskyy; Kirsten K Dietze; Yvonne P Hüsecken; Simone Schimmer; Savita Nair; Tanja Werner; Kathrin Gibbert; Olivia Kershaw; Achim D Gruber; Tim D. Sparwasser; Ulf Dittmer
The regulatory T-cell response during acute retroviral infection is locally defined and controls the magnitude and duration of the virus-specific cytotoxic T-cell response.
Blood 2009;114(15):3199-207.
2009: Sabine Siegemund; Andrea Hartl; Heiner von Buttlar; Franziska Dautel; Rüdiger Raue; Marina A Freudenberg; György Fejer; Mathias Büttner; Gabriele Köhler; Carsten J Kirschning; Tim D. Sparwasser; Gottfried Alber
Conventional bone marrow-derived dendritic cells contribute to toll-like receptor-independent production of alpha/beta interferon in response to inactivated parapoxvirus ovis.
Journal of virology 2009;83(18):9411-22.
2009: Gennadiy Zelinskyy; Kirsten Dietze; Tim D. Sparwasser; Ulf Dittmer
Regulatory T cells suppress antiviral immune responses and increase viral loads during acute infection with a lymphotropic retrovirus.
PLoS pathogens 2009;5(8):e1000406.
2009: Caroline E von Allmen; Nicole Schmitz; Monika Bauer; Heather J Hinton; Michael O Kurrer; Regula B Buser; Myriam Gwerder; Simone Muntwiler; Tim D. Sparwasser; Roger R Beerli; Martin F Bachmann
Secretory phospholipase A2-IID is an effector molecule of CD4+CD25+ regulatory T cells.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(28):11673-8.
2009: Marc Pellegrini; Thomas Calzascia; Alisha R Elford; Arda Shahinian; Amy E Lin; Dilan Dissanayake; Salim Dhanji; Linh T Nguyen; Matthew A Gronski; Michel MORRE; Brigitte Assouline; Katharina Lahl; Tim D. Sparwasser; Pamela S Ohashi; Tak W Mak
Adjuvant IL-7 antagonizes multiple cellular and molecular inhibitory networks to enhance immunotherapies.
Nature medicine 2009;15(5):528-36.
2008: Fabiola Osorio; Salomé LeibundGut-Landmann; Matthias Lochner; Katharina Lahl; Tim D. Sparwasser; Gérard Eberl; Caetano Reis e Sousa
DC activated via dectin-1 convert Treg into IL-17 producers.
European journal of immunology 2008;38(12):3274-81.
2008: Antje Heit; Friedemann Gebhardt; Katharina Lahl; Michael Neuenhahn; Frank Schmitz; Florian Anderl; Hermann Wagner; Tim D. Sparwasser; Dirk H Busch; Kathrin Kastenmüller
Circumvention of regulatory CD4(+) T cell activity during cross-priming strongly enhances T cell-mediated immunity.
European journal of immunology 2008;38(6):1585-97.
2008: Martin Schaefer; Norbert Reiling; Cornelia Fessler; Johannes Stephani; Ichiro Taniuchi; Farahnaz Hatam; Ali Oender Yildirim; Heinz Fehrenbach; Kerstin Walter; Jürgen Ruland; Hermann Wagner; Stefan Ehlers; Tim D. Sparwasser
Decreased pathology and prolonged survival of human DC-SIGN transgenic mice during mycobacterial infection.
Journal of immunology (Baltimore, Md. : 1950) 2008;180(10):6836-45.
2007: Tim D. Sparwasser; Gérard Eberl
BAC to immunology--bacterial artificial chromosome-mediated transgenesis for targeting of immune cells.
Immunology 2007;121(3):308-13.
2007: Katharina Lahl; Christoph Loddenkemper; Cathy Drouin; Jennifer Freyer; Jon Arnason; Gérard Eberl; Alf Hamann; Hermann Wagner; Jochen Huehn; Tim D. Sparwasser
Selective depletion of Foxp3+ regulatory T cells induces a scurfy-like disease.
The Journal of experimental medicine 2007;204(1):57-63.
2006: Olaf Gross; Andreas Gewies; Katrin Finger; Martin Schäfer; Tim D. Sparwasser; Christian Peschel; Irmgard Förster; Jürgen Ruland
Card9 controls a non-TLR signalling pathway for innate anti-fungal immunity.
Nature 2006;442(7103):651-6.
2006: Stefanie Klemm; Jan Gutermuth; Lothar Hültner; Tim D. Sparwasser; Heidrun Behrendt; Christian Peschel; Tak W Mak; Thilo Jakob; Jürgen Ruland
The Bcl10-Malt1 complex segregates Fc epsilon RI-mediated nuclear factor kappa B activation and cytokine production from mast cell degranulation.
The Journal of experimental medicine 2006;203(2):337-47.
2006: Ferdinand von Meyenn; Martin Schaefer; Heike Weighardt; Stefan Bauer; Carsten J Kirschning; Hermann Wagner; Tim D. Sparwasser
Toll-like receptor 9 contributes to recognition of Mycobacterium bovis Bacillus Calmette-Guérin by Flt3-ligand generated dendritic cells.
Immunobiology 2006;211(6-8):557-65.
2004: Tim D. Sparwasser; Shiaoching Gong; James Y H Li; Gérard Eberl
General method for the modification of different BAC types and the rapid generation of BAC transgenic mice.
Genesis (New York, N.Y. : 2000) 2004;38(1):39-50.
2002: Steffen Jung; Derya Unutmaz; Phillip Wong; Gen-Ichiro Sano; Kenia De los Santos; Tim D. Sparwasser; Shengji Wu; Srilatha Vuthoori; Kyung Ko; Fidel Zavala; Eric G Pamer; Dan R Littman; Richard Lang
In vivo depletion of CD11c+ dendritic cells abrogates priming of CD8+ T cells by exogenous cell-associated antigens.
Immunity 2002;17(2):211-20.
2001: Frédéric Baribaud; Stefan Pöhlmann; Tim D. Sparwasser; M T Kimata; Y K Choi; Beth Haggarty; Navid Ahmad; Todd Macfarlan; Terri G Edwards; George J Leslie; J Arnason; T A Reinhart; J T Kimata; Dan R Littman; James A Hoxie; Robert W Doms
Functional and antigenic characterization of human, rhesus macaque, pigtailed macaque, and murine DC-SIGN.
Journal of virology 2001;75(21):10281-9.
2000: Tim D. Sparwasser; Ramunas M Vabulas; Brigitte Villmow; Grayson Lipford; Hermann Wagner
Bacterial CpG-DNA activates dendritic cells in vivo: T helper cell-independent cytotoxic T cell responses to soluble proteins.
European journal of immunology 2000;30(12):3591-7.
2000: Grayson Lipford; Tim D. Sparwasser; S Zimmermann; Klaus Heeg; Hermann Wagner
CpG-DNA-mediated transient lymphadenopathy is associated with a state of Th1 predisposition to antigen-driven responses.
Journal of immunology (Baltimore, Md. : 1950) 2000;165(3):1228-35.
2000: Thomas Decker; Folker Schneller; Tim D. Sparwasser; T Tretter; Grayson Lipford; H Wagner; Christian Peschel
Immunostimulatory CpG-oligonucleotides cause proliferation, cytokine production, and an immunogenic phenotype in chronic lymphocytic leukemia B cells.
Blood 2000;95(3):999-1006.
2000: Grayson Lipford; Tim D. Sparwasser
Hematopoietic remodeling triggered by CpG DNA.
Current topics in microbiology and immunology 2000;247():119-29.
2000: Tim D. Sparwasser; Grayson Lipford
Consequences of bacterial CpG DNA-driven activation of antigen-presenting cells.
Current topics in microbiology and immunology 2000;247():59-75.
1999: Tim D. Sparwasser; Lothar Hültner; ES Koch; A Luz; Grayson Lipford; Hermann Wagner
Immunostimulatory CpG-oligodeoxynucleotides cause extramedullary murine hemopoiesis.
Journal of immunology (Baltimore, Md. : 1950) 1999;162(4):2368-74.
1998: Hans Häcker; H Mischak; Thomas Miethke; S Liptay; R Schmid; Tim D. Sparwasser; Klaus Heeg; Grayson Lipford; Hermann Wagner
CpG-DNA-specific activation of antigen-presenting cells requires stress kinase activity and is preceded by non-specific endocytosis and endosomal maturation.
The EMBO journal 1998;17(21):6230-40.
1998: Klaus Heeg; Tim D. Sparwasser; Grayson Lipford; Hans Häcker; S Zimmermann; H Wagner
Bacterial DNA as an evolutionary conserved ligand signalling danger of infection to immune cells.
European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology 1998;17(7):464-9.
1998: Tim D. Sparwasser; ES Koch; Ramunas M Vabulas; Klaus Heeg; Grayson Lipford; J W Ellwart; Hermann Wagner
Bacterial DNA and immunostimulatory CpG oligonucleotides trigger maturation and activation of murine dendritic cells.
European journal of immunology 1998;28(6):2045-54.
1997: Grayson Lipford; Tim D. Sparwasser; M Bauer; S Zimmermann; ES Koch; Klaus Heeg; Hermann Wagner
Immunostimulatory DNA: sequence-dependent production of potentially harmful or useful cytokines.
European journal of immunology 1997;27(12):3420-6.
1997: Tim D. Sparwasser; Thomas Miethke; Grayson Lipford; A Erdmann; Hans Häcker; Klaus Heeg; Hermann Wagner
Macrophages sense pathogens via DNA motifs: induction of tumor necrosis factor-alpha-mediated shock.
European journal of immunology 1997;27(7):1671-9.
1997: Tim D. Sparwasser; Thomas Miethke; Grayson Lipford; K Borschert; Hans Häcker; Klaus Heeg; H Wagner
Bacterial DNA causes septic shock.
Nature 1997;386(6623):336-7.