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John Francis Healey

Research Profile

Chemicals & Drugs

Disorders

Hemophilia A

Living Beings

Swine
Mouse

Anatomy

Co-author Network

Publications

TOP 3
Ryan J Summers; Shannon L Meeks; John Francis Healey; Harrison C Brown; Ernest T Parker; Christine Luise Kempton; Christopher B Doering; Pete Lollar
Factor VIII A3 domain substitution N1922S results in hemophilia A due to domain-specific misfolding and hyposecretion of functional protein.
S L Meeks; John Francis Healey; Ernest T Parker; Rachel T Barrow; Pete Lollar
Non-classical anti-factor VIII C2 domain antibodies are pathogenic in a murine in vivo bleeding model.
Shannon L Meeks; John Francis Healey; Ernest T Parker; Rachel T Barrow; Pete Lollar
Nonclassical anti-C2 domain antibodies are present in patients with factor VIII inhibitors.

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All Publications

2011: Ryan J Summers; Shannon L Meeks; John Francis Healey; Harrison C Brown; Ernest T Parker; Christine Luise Kempton; Christopher B Doering; Pete Lollar
Factor VIII A3 domain substitution N1922S results in hemophilia A due to domain-specific misfolding and hyposecretion of functional protein.
Blood 2011;117(11):3190-8.
2009: S L Meeks; John Francis Healey; Ernest T Parker; Rachel T Barrow; Pete Lollar
Non-classical anti-factor VIII C2 domain antibodies are pathogenic in a murine in vivo bleeding model.
Journal of thrombosis and haemostasis : JTH 2009;7(4):658-64.
2008: Shannon L Meeks; John Francis Healey; Ernest T Parker; Rachel T Barrow; Pete Lollar
Nonclassical anti-C2 domain antibodies are present in patients with factor VIII inhibitors.
Blood 2008;112(4):1151-3.
2007: Shannon L Meeks; John Francis Healey; Ernest T Parker; Rachel T Barrow; Pete Lollar
Antihuman factor VIII C2 domain antibodies in hemophilia A mice recognize a functionally complex continuous spectrum of epitopes dominated by inhibitors of factor VIII activation.
Blood 2007;110(13):4234-42.
2007: John Francis Healey; Ernest T Parker; Rachel T Barrow; T J Langley; W R Church; Pete Lollar
The humoral response to human factor VIII in hemophilia A mice.
Journal of thrombosis and haemostasis : JTH 2007;5(3):512-9.
2004: Ernest T Parker; John Francis Healey; Rachel T Barrow; Heather N Craddock; Pete Lollar
Reduction of the inhibitory antibody response to human factor VIII in hemophilia A mice by mutagenesis of the A2 domain B-cell epitope.
Blood 2004;104(3):704-10.
2004: Christopher B Doering; John Francis Healey; Ernest T Parker; Rachel T Barrow; Pete Lollar
Identification of porcine coagulation factor VIII domains responsible for high level expression via enhanced secretion.
The Journal of biological chemistry 2004;279(8):6546-52.
2002: Christopher B Doering; John Francis Healey; Ernest T Parker; Rachel T Barrow; Pete Lollar
High level expression of recombinant porcine coagulation factor VIII.
The Journal of biological chemistry 2002;277(41):38345-9.
2002: Christopher B Doering; Ernest T Parker; John Francis Healey; Heather N Craddock; Rachel T Barrow; Pete Lollar
Expression and characterization of recombinant murine factor VIII.
Thrombosis and haemostasis 2002;88(3):450-8.
2002: Yi Lin; Liming Chang; Anna Solovey; John Francis Healey; Pete Lollar; Robert P Hebbel
Use of blood outgrowth endothelial cells for gene therapy for hemophilia A.
Blood 2002;99(2):457-62.
2001: Pete Lollar; John Francis Healey; Rachel T Barrow; Ernest T Parker
Factor VIII inhibitors.
Advances in experimental medicine and biology 2001;489():65-73.
2001: Rachel T Barrow; John Francis Healey; Marc Jacquemin; Jean-Marie Saint-Remy; Pete Lollar
Antigenicity of putative phospholipid membrane-binding residues in factor VIII.
Blood 2001;97(1):169-74.
2000: Rachel T Barrow; John Francis Healey; D Gailani; Dorothea Scandella; Pete Lollar
Reduction of the antigenicity of factor VIII toward complex inhibitory antibody plasmas using multiply-substituted hybrid human/porcine factor VIII molecules.
Blood 2000;95(2):564-8.
1999: H Do; John Francis Healey; Edmond WALLER; Pete Lollar
Expression of factor VIII by murine liver sinusoidal endothelial cells.
The Journal of biological chemistry 1999;274(28):19587-92.
1998: John Francis Healey; Rachel T Barrow; H M Tamim; I M Lubin; M Shima; Dorothea Scandella; Pete Lollar
Residues Glu2181-Val2243 contain a major determinant of the inhibitory epitope in the C2 domain of human factor VIII.
Blood 1998;92(10):3701-9.
1997: I M Lubin; John Francis Healey; Rachel T Barrow; Dorothea Scandella; Pete Lollar
Analysis of the human factor VIII A2 inhibitor epitope by alanine scanning mutagenesis.
The Journal of biological chemistry 1997;272(48):30191-5.
1997: Arthur R Thompson; ME Murphy; M Liu; Evgueni L Saenko; John Francis Healey; Pete Lollar; Dorothea Scandella
Loss of tolerance to exogenous and endogenous factor VIII in a mild hemophilia A patient with an Arg593 to Cys mutation.
Blood 1997;90(5):1902-10.
1996: John Francis Healey; I M Lubin; Pete Lollar
The cDNA and derived amino acid sequence of porcine factor VIII.
Blood 1996;88(11):4209-14.
1995: John Francis Healey; I M Lubin; H Nakai; Evgueni L Saenko; L W Hoyer; Dorothea Scandella; Pete Lollar
Residues 484-508 contain a major determinant of the inhibitory epitope in the A2 domain of human factor VIII.
The Journal of biological chemistry 1995;270(24):14505-9.
1994: I M Lubin; John Francis Healey; Dorothea Scandella; Marschall S Runge; Pete Lollar
Elimination of a major inhibitor epitope in factor VIII.
The Journal of biological chemistry 1994;269(12):8639-41.
1994: Rachel T Barrow; John Francis Healey; Pete Lollar
Inhibition by heparin of thrombin-catalyzed activation of the factor VIII-von Willebrand factor complex.
The Journal of biological chemistry 1994;269(1):593-8.
1991: Edward Cable; John Francis Healey; Y Greene; Chheng-Orn Evans; Herbert L Bonkovsky
Synergistic induction of delta-aminolevulinate synthase by glutethimide and iron: relationship to the synergistic induction of heme oxygenase.
Biochimica et biophysica acta 1991;1080(3):245-51.
1991: Herbert L Bonkovsky; John Francis Healey; A N Lourie; G G Gerron
Intravenous heme-albumin in acute intermittent porphyria: evidence for repletion of hepatic hemoproteins and regulatory heme pools.
The American journal of gastroenterology 1991;86(8):1050-6.
1991: Chheng-Orn Evans; John Francis Healey; Y Greene; Herbert L Bonkovsky
Cloning, sequencing and expression of cDNA for chick liver haem oxygenase. Comparison of avian and mammalian cDNAs and deduced proteins.
The Biochemical journal 1991;273 ( Pt 3)():659-66.
1990: Herbert L Bonkovsky; John Francis Healey; J Pohl
Purification and characterization of heme oxygenase from chick liver. Comparison of the avian and mammalian enzymes.
European journal of biochemistry / FEBS 1990;189(1):155-66.
1990: E Cable; Y Greene; John Francis Healey; Chheng-Orn Evans; Herbert L Bonkovsky
Mechanism of synergistic induction of hepatic heme oxygenase by glutethimide and iron: studies in cultured chick embryo liver cells.
Biochemical and biophysical research communications 1990;168(1):176-81.
1989: P Sinclair; J Frezza; J Sinclair; W Bement; S Haugen; John Francis Healey; Herbert L Bonkovsky
Immunochemical detection of different isoenzymes of cytochrome P-450 induced in chick hepatocyte cultures.
The Biochemical journal 1989;258(1):237-45.
1988: B C Lincoln; John Francis Healey; Herbert L Bonkovsky
Regulation of hepatic haem metabolism. Disparate mechanisms of induction of haem oxygenase by drugs and metals.
The Biochemical journal 1988;250(1):189-96.
1987: Herbert L Bonkovsky; John Francis Healey; B Lincoln; B R Bacon; D F Bishop; G H Elder
Hepatic heme synthesis in a new model of experimental hemochromatosis: studies in rats fed finely divided elemental iron.
Hepatology (Baltimore, Md.) 1987;7(6):1195-203.
1986: Herbert L Bonkovsky; B Lincoln; John Francis Healey; L C Ou; P R Sinclair; U Muller-Eberhard
Hepatic heme and drug metabolism in rats with chronic mountain sickness.
The American journal of physiology 1986;251(4 Pt 1):G467-74.
1986: Herbert L Bonkovsky; S G Wood; S K Howell; P R Sinclair; B Lincoln; John Francis Healey; J F Sinclair
High-performance liquid chromatographic separation and quantitation of tetrapyrroles from biological materials.
Analytical biochemistry 1986;155(1):56-64.
1980: L C Ou; John Francis Healey; H L Bonkowsky; P Sinclair
Hepatic cytochrome P-450 in chronically hypoxemic rats.
Biochemical and biophysical research communications 1980;96(3):1128-34.