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Valeria Bruno

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Luisa Di Menna; Luigi Di Nuzzo; Gemma Molinaro; Ferdinando Nicoletti; Carlo Pozzilli; Barbara Riozzi; Renato Turrini; Cristina Zappulla; Giuseppe Battaglia; Filippo Caraci; Agata Copani; Valeria Bruno
Fingolimod protects cultured cortical neurons against excitotoxic death.
Simona Federica Spampinato; Giuseppe Battaglia; Valeria Bruno; Sara Merlo; Gemma Molinaro; Ferdinando Nicoletti; Maria Angela Sortino
Dual effect of 17β-estradiol on NMDA-induced neuronal death: involvement of metabotropic glutamate receptor 1.
Filippo Caraci; Agata Copani; Gemma Molinaro; Ferdinando Nicoletti; Maria Angela Sortino; Simona Spampinato; Giuseppe Battaglia; Valeria Bruno
Metabotropic glutamate receptors in neurodegeneration/neuroprotection: still a hot topic?

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All Publications

2013: Luisa Di Menna; Luigi Di Nuzzo; Gemma Molinaro; Ferdinando Nicoletti; Carlo Pozzilli; Barbara Riozzi; Renato Turrini; Cristina Zappulla; Giuseppe Battaglia; Filippo Caraci; Agata Copani; Valeria Bruno
Fingolimod protects cultured cortical neurons against excitotoxic death.
Pharmacological research : the official journal of the Italian Pharmacological Society 2013;67(1):1-9.
2012: Simona Federica Spampinato; Giuseppe Battaglia; Valeria Bruno; Sara Merlo; Gemma Molinaro; Ferdinando Nicoletti; Maria Angela Sortino
Dual effect of 17β-estradiol on NMDA-induced neuronal death: involvement of metabotropic glutamate receptor 1.
Endocrinology 2012;153(12):5940-8.
2012: Filippo Caraci; Agata Copani; Gemma Molinaro; Ferdinando Nicoletti; Maria Angela Sortino; Simona Spampinato; Giuseppe Battaglia; Valeria Bruno
Metabotropic glutamate receptors in neurodegeneration/neuroprotection: still a hot topic?
Neurochemistry international 2012;61(4):559-65.
2012: F Fazio; Francine Acher; Giuseppe Battaglia; Hugues-Olivier BERTRAND; Valeria Bruno; M Curini; R Di Marco; L Lionetto; Gemma Molinaro; Richard Teke Ngomba; F Nicoletti; S Notartomaso; Jean-Philippe Pin; O Rosati; P Scarselli; M Simmaco; Cyril Goudet
Cinnabarinic acid, an endogenous metabolite of the kynurenine pathway, activates type 4 metabotropic glutamate receptors.
Molecular pharmacology 2012;81(5):643-56.
2012: Simona Federica Spampinato; Luisa Iacovelli; Sara Merlo; Giuseppe Battaglia; Ferdinando Nicoletti; Gemma Molinaro; Valeria Bruno; Filippo Caraci; Maria Angela Sortino
Estrogen receptors and type 1 metabotropic glutamate receptors are interdependent in protecting cortical neurons against β-amyloid toxicity.
Molecular pharmacology 2012;81(1):12-20.
2012: Filippo Caraci; Paolo Bosco; Filippo Drago; Giuseppe Battaglia; Ferdinando Nicoletti; Valeria Bruno; Simona Spampinato; Maria Angela Sortino; Agata Copani
Dysfunction of TGF-β1 signaling in Alzheimer's disease: perspectives for neuroprotection.
Cell and tissue research 2012;347(1):291-301.
2011: Filippo Caraci; Viviana Carbonaro; Giuseppe Battaglia; Paolo Bosco; Valeria Bruno; Filippo Drago; Maria Laura Giuffrida; Ferdinando Nicoletti; Maria Angela Sortino; Agata Copani
TGF-β1 pathway as a new target for neuroprotection in Alzheimer's disease.
CNS neuroscience & therapeutics 2011;17(4):237-49.
2011: Richard Teke Ngomba; I Santolini; F Biagioni; G Molinaro; Agnes Simonyi; Clementina van Rijn; V D'Amore; F Mastroiacovo; G Olivieri; R Gradini; F Ferraguti; Giuseppe Battaglia; Valeria Bruno; A Puliti; Gilles van Luijtelaar; F Nicoletti
Protective role for type-1 metabotropic glutamate receptors against spike and wave discharges in the WAG/Rij rat model of absence epilepsy.
Neuropharmacology 2011;60(7-8):1281-91.
2011: Slavianka G Moyanova; Federica Mastroiacovo; Lidia V Kortenska; Rumiana G Mitreva; Erminia Fardone; Ines Santolini; Mónica Sobrado; Giuseppe Battaglia; Valeria Bruno; Ferdinando Nicoletti; Richard Teke Ngomba
Protective role for type 4 metabotropic glutamate receptors against ischemic brain damage.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2011;31(4):1107-18.
2011: Filippo Caraci; Gemma Molinaro; Giuseppe Battaglia; Maria Laura Giuffrida; Barbara Riozzi; Anna Traficante; Valeria Bruno; Milena Cannella; Sara Merlo; Xushan Wang; Beverly A Heinz; Eric S Nisenbaum; Thomas C Britton; Filippo Drago; Maria Angela Sortino; Agata Copani; Ferdinando Nicoletti
Targeting group II metabotropic glutamate (mGlu) receptors for the treatment of psychosis associated with Alzheimer's disease: selective activation of mGlu2 receptors amplifies beta-amyloid toxicity in cultured neurons, whereas dual activation of mGlu2 and mGlu3 receptors is neuroprotective.
Molecular pharmacology 2011;79(3):618-26.
2011: Giuseppe Battaglia; Milena Cannella; Barbara Riozzi; Sara Orobello; Marion L Maat-Schieman; Eleonora Aronica; Carla Letizia Busceti; Andrea Ciarmiello; Silvia Alberti; Enrico Amico; Jenny Sassone; Simonetta Sipione; Valeria Bruno; Luigi Frati; Ferdinando Nicoletti; Ferdinando Squitieri
Early defect of transforming growth factor β1 formation in Huntington's disease.
Journal of cellular and molecular medicine 2011;15(3):555-71.
2011: Francesco Matrisciano; Carla L Busceti; Domenico Bucci; Rosamaria Orlando; Alessandra Caruso; Gemma Molinaro; Irene Cappuccio; Barbara Riozzi; Roberto Gradini; Marta Motolese; Filippo Caraci; Agata Copani; Sergio Scaccianoce; Daniela Melchiorri; Valeria Bruno; Giuseppe Battaglia; Ferdinando Nicoletti
Induction of the Wnt antagonist Dickkopf-1 is involved in stress-induced hippocampal damage.
PloS one 2011;6(1):e16447.
2011: Valeria Bruno; Giuseppe Battaglia; Ferdinando Nicoletti
The advent of monoclonal antibodies in the treatment of chronic autoimmune diseases.
Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology 2011;31 Suppl 3():283-8.
2010: Francesca Fallarino; Claudia Volpi; Francesco Fazio; Serena Notartomaso; Carmine Vacca; Carla Busceti; Silvio Bicciato; Giuseppe Battaglia; Valeria Bruno; Paolo Puccetti; Maria C Fioretti; Ferdinando Nicoletti; Ursula Grohmann; Roberto Di Marco
Metabotropic glutamate receptor-4 modulates adaptive immunity and restrains neuroinflammation.
Nature medicine 2010;16(8):897-902.
2010: Gemma Molinaro; Sara Pietracupa; Luisa Di Menna; Lorenzo Pescatori; Alessandro Usiello; Giuseppe Battaglia; Ferdinando Nicoletti; Valeria Bruno
D-aspartate activates mGlu receptors coupled to polyphosphoinositide hydrolysis in neonate rat brain slices.
Neuroscience letters 2010;478(3):128-30.
2009: Maria Laura Giuffrida; Filippo Caraci; Bruno Pignataro; Sebastiano Cataldo; Paolo De Bona; Valeria Bruno; Gemma Molinaro; Giuseppe Pappalardo; Angela Messina; Angelo Palmigiano; Domenico Garozzo; Ferdinando Nicoletti; Enrico Rizzarelli; Agata Copani
Beta-amyloid monomers are neuroprotective.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2009;29(34):10582-7.
2009: Gemma Molinaro; A Traficante; Barbara Riozzi; L Di Menna; M Curto; S Pallottino; Ferdinando Nicoletti; Valeria Bruno; Giuseppe Battaglia
Activation of mGlu2/3 metabotropic glutamate receptors negatively regulates the stimulation of inositol phospholipid hydrolysis mediated by 5-hydroxytryptamine2A serotonin receptors in the frontal cortex of living mice.
Molecular pharmacology 2009;76(2):379-87.
2009: Gemma Molinaro; Giuseppe Battaglia; Barbara Riozzi; Luisa Di Menna; Liborio Rampello; Valeria Bruno; Ferdinando Nicoletti
Memantine treatment reduces the expression of the K(+)/Cl(-) cotransporter KCC2 in the hippocampus and cerebral cortex, and attenuates behavioural responses mediated by GABA(A) receptor activation in mice.
Brain research 2009;1265():75-9.
2009: L Iacovelli; G Molinaro; Giuseppe Battaglia; M Motolese; L Di Menna; M Alfiero; J Blahos; Francesco Matrisciano; M Corsi; C Corti; Valeria Bruno; A De Blasi; F Nicoletti
Regulation of group II metabotropic glutamate receptors by G protein-coupled receptor kinases: mGlu2 receptors are resistant to homologous desensitization.
Molecular pharmacology 2009;75(4):991-1003.
2009: Philip Seeman; Giuseppe Battaglia; Corrado Corti; Mauro Corsi; Valeria Bruno
Glutamate receptor mGlu2 and mGlu3 knockout striata are dopamine supersensitive, with elevated D2(High) receptors and marked supersensitivity to the dopamine agonist (+)PHNO.
Synapse (New York, N.Y.) 2009;63(3):247-51.
2009: Federica Mastroiacovo; Carla L Busceti; Francesca Biagioni; Slavianka G Moyanova; Miriam H Meisler; Giuseppe Battaglia; Andrea Caricasole; Valeria Bruno; Ferdinando Nicoletti
Induction of the Wnt antagonist, Dickkopf-1, contributes to the development of neuronal death in models of brain focal ischemia.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2009;29(2):264-76.
2009: Giuseppe Battaglia; Gemma Molinaro; Barbara Riozzi; marianna storto; Carla L Busceti; Paola Spinsanti; Domenico Bucci; Valentina Di Liberto; Giuseppa Mudò; Corrado Corti; Mauro Corsi; Ferdinando Nicoletti; Natale Belluardo; Valeria Bruno
Activation of mGlu3 receptors stimulates the production of GDNF in striatal neurons.
PloS one 2009;4(8):e6591.
2008: Simona D'Antoni; Antonio Berretta; Carmela Maria Bonaccorso; Valeria Bruno; Eleonora Aronica; Ferdinando Nicoletti; Maria Vincenza Catania
Metabotropic glutamate receptors in glial cells.
Neurochemical research 2008;33(12):2436-43.
2008: Filippo Caraci; Carla Busceti; Francesca Biagioni; Eleonora Aronica; Federica Mastroiacovo; Irene Cappuccio; Giuseppe Battaglia; Valeria Bruno; Andrea Caricasole; Agata Copani; Ferdinando Nicoletti
The Wnt antagonist, Dickkopf-1, as a target for the treatment of neurodegenerative disorders.
Neurochemical research 2008;33(12):2401-6.
2008: F Fazio; S Notartomaso; E Aronica; marianna storto; Giuseppe Battaglia; E Vieira; S Gatti; Valeria Bruno; F Biagioni; R Gradini; F Nicoletti; Roberto Di Marco
Switch in the expression of mGlu1 and mGlu5 metabotropic glutamate receptors in the cerebellum of mice developing experimental autoimmune encephalomyelitis and in autoptic cerebellar samples from patients with multiple sclerosis.
Neuropharmacology 2008;55(4):491-9.
2008: Francesco Matrisciano; A Caruso; R Orlando; M Marchiafava; Valeria Bruno; Giuseppe Battaglia; S H M Gruber; D Melchiorri; R Tatarelli; P Girardi; A A Mathè; F Nicoletti
Defective group-II metaboropic glutamate receptors in the hippocampus of spontaneously depressed rats.
Neuropharmacology 2008;55(4):525-31.
2008: samantha messina; Gemma Molinaro; Valeria Bruno; Giuseppe Battaglia; Paola Spinsanti; Alba Di Pardo; Ferdinando Nicoletti; Luigi Frati; Antonio Porcellini
Enhanced expression of Harvey ras induced by serum deprivation in cultured astrocytes.
Journal of neurochemistry 2008;106(2):551-9.
2008: Carla L Busceti; Francesca Biagioni; Barbara Riozzi; Giuseppe Battaglia; marianna storto; Carlo Cinque; Gemma Molinaro; Roberto Gradini; Andrea Caricasole; Anna Maria Canudas; Valeria Bruno; Ferdinando Nicoletti; Francesco Fornai
Enhanced tau phosphorylation in the hippocampus of mice treated with 3,4-methylenedioxymethamphetamine ("Ecstasy").
The Journal of neuroscience : the official journal of the Society for Neuroscience 2008;28(12):3234-45.
2008: Gemma Molinaro; Giuseppe Battaglia; Barbara Riozzi; marianna storto; Sergio Fucile; Fabrizio Eusebi; Ferdinando Nicoletti; Valeria Bruno
GABAergic drugs become neurotoxic in cortical neurons pre-exposed to brain-derived neurotrophic factor.
Molecular and cellular neurosciences 2008;37(2):312-22.
2008: Richard Teke Ngomba; F Ferraguti; A Badura; R Citraro; I Santolini; Giuseppe Battaglia; Valeria Bruno; G De Sarro; Agnes Simonyi; Gilles van Luijtelaar; Ferdinando Nicoletti
Positive allosteric modulation of metabotropic glutamate 4 (mGlu4) receptors enhances spontaneous and evoked absence seizures.
Neuropharmacology 2008;54(2):344-54.
2007: Rosamaria Orlando; Alessandra Caruso; Gemma Molinaro; Marta Motolese; Francesco Matrisciano; Giuseppina Togna; Daniela Melchiorri; Ferdinando Nicoletti; Valeria Bruno
Nanomolar concentrations of anabolic-androgenic steroids amplify excitotoxic neuronal death in mixed mouse cortical cultures.
Brain research 2007;1165():21-9.
2007: Corrado Corti; Giuseppe Battaglia; Gemma Molinaro; Barbara Riozzi; Anna Pittaluga; Mauro Corsi; Manolo Mugnaini; Ferdinando Nicoletti; Valeria Bruno
The use of knock-out mice unravels distinct roles for mGlu2 and mGlu3 metabotropic glutamate receptors in mechanisms of neurodegeneration/neuroprotection.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2007;27(31):8297-308.
2007: Ferdinando Nicoletti; Giuseppe Battaglia; marianna storto; Richard Teke Ngomba; Luisa Iacovelli; Antonietta Arcella; Roberto Gradini; sale Patrizio; Liborio Rampello; Teresa De Vita; Roberto Di Marco; Daniela Melchiorri; Valeria Bruno
Metabotropic glutamate receptors: beyond the regulation of synaptic transmission.
Psychoneuroendocrinology 2007;32 Suppl 1():S40-5.
2007: Gloria Lazzeri; Paola Lenzi; Carla L Busceti; Michela Ferrucci; Alessandra Falleni; Valeria Bruno; Antonio Paparelli; Francesco Fornai
Mechanisms involved in the formation of dopamine-induced intracellular bodies within striatal neurons.
Journal of neurochemistry 2007;101(5):1414-27.
2007: Renata Ciccarelli; Iolanda D'Alimonte; Patrizia Ballerini; Mariagrazia D'Auro; Eleonora Nargi; Silvana Buccella; Patrizia Di Iorio; Valeria Bruno; Ferdinando Nicoletti; Francesco Caciagli
Molecular signalling mediating the protective effect of A1 adenosine and mGlu3 metabotropic glutamate receptor activation against apoptosis by oxygen/glucose deprivation in cultured astrocytes.
Molecular pharmacology 2007;71(5):1369-80.
2007: Carla L Busceti; Francesca Biagioni; Eleonora Aronica; Barbara Riozzi; marianna storto; Giuseppe Battaglia; Filippo S Giorgi; Roberto Gradini; Francesco Fornai; Andrea Caricasole; Ferdinando Nicoletti; Valeria Bruno
Induction of the Wnt inhibitor, Dickkopf-1, is associated with neurodegeneration related to temporal lobe epilepsy.
Epilepsia 2007;48(4):694-705.
2007: Alina Beraudi; Valeria Bruno; Giuseppe Battaglia; Francesca Biagioni; Liborio Rampello; Ferdinando Nicoletti; Alessandro Poli
Pharmacological activation of mGlu2/3 metabotropic glutamate receptors protects retinal neurons against anoxic damage in the goldfish Carassius auratus.
Experimental eye research 2007;84(3):544-52.
2006: Gloria Lazzeri; Paola Lenzi; Marco Gesi; Michela Ferrucci; Federica Fulceri; Stefano Ruggieri; Valeria Bruno; Francesco Fornai
In PC12 cells neurotoxicity induced by methamphetamine is related to proteasome inhibition.
Annals of the New York Academy of Sciences 2006;1074():174-7.
2006: Giuseppe Battaglia; Carla L Busceti; Gemma Molinaro; Francesca Biagioni; Anna Traficante; Ferdinando Nicoletti; Valeria Bruno
Pharmacological activation of mGlu4 metabotropic glutamate receptors reduces nigrostriatal degeneration in mice treated with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2006;26(27):7222-9.
2006: Laura Calò; Carlo Cinque; Monica Patanè; Danilo Schillaci; Giuseppe Battaglia; Daniela Melchiorri; Ferdinando Nicoletti; Valeria Bruno
Interaction between ephrins/Eph receptors and excitatory amino acid receptors: possible relevance in the regulation of synaptic plasticity and in the pathophysiology of neuronal degeneration.
Journal of neurochemistry 2006;98(1):1-10.
2006: marianna storto; Loredana Capobianco; Giuseppe Battaglia; Gemma Molinaro; Roberto Gradini; Barbara Riozzi; Alessandra Di Mambro; Kathryn J Mitchell; Valeria Bruno; Mariapia Vairetti; Guy Rutter; Ferdinando Nicoletti
Insulin secretion is controlled by mGlu5 metabotropic glutamate receptors.
Molecular pharmacology 2006;69(4):1234-41.
2006: Liborio Rampello; Alessandro Alvano; Giuseppe Battaglia; Valeria Bruno; Rocco Raffaele; Ferdinando Nicoletti
Tic disorders: from pathophysiology to treatment.
Journal of neurology 2006;253(1):1-15.
2005: Concetta Marganella; Valeria Bruno; Francesco Matrisciano; Carlo Reale; Ferdinando Nicoletti; Daniela Melchiorri
Comparative effects of levobupivacaine and racemic bupivacaine on excitotoxic neuronal death in culture and N-methyl-D-aspartate-induced seizures in mice.
European journal of pharmacology 2005;518(2-3):111-5.
2005: Antonietta Arcella; Giulia Carpinelli; Giuseppe Battaglia; Mara D'Onofrio; Filippo Santoro; Richard Teke Ngomba; Valeria Bruno; Paola Casolini; Felice Giangaspero; Ferdinando Nicoletti
Pharmacological blockade of group II metabotropic glutamate receptors reduces the growth of glioma cells in vivo.
Neuro-oncology 2005;7(3):236-45.
2005: Irene Cappuccio; Agata Calderone; Carla L Busceti; Francesca Biagioni; Fabrizio Pontarelli; Valeria Bruno; marianna storto; Georg T Terstappen; Giovanni Gaviraghi; Francesco Fornai; Giuseppe Battaglia; Daniela Melchiorri; R Suzanne Zukin; Suzanne Zukin; Ferdinando Nicoletti; Andrea Caricasole
Induction of Dickkopf-1, a negative modulator of the Wnt pathway, is required for the development of ischemic neuronal death.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2005;25(10):2647-57.
2005: L Calò; Valeria Bruno; Paola Spinsanti; G Molinari; Vladimir M Korkhov; Z Esposito; M Patanè; Daniela Melchiorri; Michael Freissmuth; Ferdinando Nicoletti
Interactions between ephrin-B and metabotropic glutamate 1 receptors in brain tissue and cultured neurons.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2005;25(9):2245-54.
2005: Richard Teke Ngomba; Francesca Biagioni; S Casciato; E Willems-van Bree; Giuseppe Battaglia; Valeria Bruno; Ferdinando Nicoletti; Gilles van Luijtelaar
The preferential mGlu2/3 receptor antagonist, LY341495, reduces the frequency of spike-wave discharges in the WAG/Rij rat model of absence epilepsy.
Neuropharmacology 2005;49 Suppl 1():89-103.
2004: marianna storto; Giuseppe Battaglia; Roberto Gradini; Valeria Bruno; Ferdinando Nicoletti; Mariapia Vairetti
Mouse hepatocytes lacking mGlu5 metabotropic glutamate receptors are less sensitive to hypoxic damage.
European journal of pharmacology 2004;497(1):25-7.
2004: Alessandra Caruso; Valeria Di Giorgi Gerevini; Marzia Castiglione; Fabiana Marinelli; Valentina Tomassini; Carlo Pozzilli; Andrea Caricasole; Valeria Bruno; Francesco Caciagli; A Moretti; Ferdinando Nicoletti; Daniela Melchiorri
Testosterone amplifies excitotoxic damage of cultured oligodendrocytes.
Journal of neurochemistry 2004;88(5):1179-85.
2004: Giuseppe Battaglia; Carla L Busceti; Gemma Molinaro; Francesca Biagioni; marianna storto; Francesco Fornai; Ferdinando Nicoletti; Valeria Bruno
Endogenous activation of mGlu5 metabotropic glutamate receptors contributes to the development of nigro-striatal damage induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine in mice.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2004;24(4):828-35.
2003: M Maj; Valeria Bruno; Z Dragic; R Yamamoto; Giuseppe Battaglia; Werner Inderbitzin; Natacha Stoehr; T Stein; Fabrizio Gasparini; Ivo Vranesic; Rainer Kuhn; Ferdinando Nicoletti; Peter J Flor
(-)-PHCCC, a positive allosteric modulator of mGluR4: characterization, mechanism of action, and neuroprotection.
Neuropharmacology 2003;45(7):895-906.
2003: Giuseppe Battaglia; Carla L Busceti; Fabrizio Pontarelli; Francesca Biagioni; Francesco Fornai; Antonio Paparelli; Valeria Bruno; Stefano Ruggieri; Ferdinando Nicoletti
Protective role of group-II metabotropic glutamate receptors against nigro-striatal degeneration induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine in mice.
Neuropharmacology 2003;45(2):155-66.
2003: Mara D'Onofrio; Antonietta Arcella; Valeria Bruno; Richard Teke Ngomba; Giuseppe Battaglia; Vincenza Lombari; Giuseppe Ragona; Antonella Calogero; Ferdinando Nicoletti
Pharmacological blockade of mGlu2/3 metabotropic glutamate receptors reduces cell proliferation in cultured human glioma cells.
Journal of neurochemistry 2003;84(6):1288-95.
2002: Andrea Caricasole; Valeria Bruno; Irene Cappuccio; Daniela Melchiorri; Agata Copani; Ferdinando Nicoletti
A novel rat gene encoding a Humanin-like peptide endowed with broad neuroprotective activity.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2002;16(10):1331-3.
2002: Luisa Iacovelli; Valeria Bruno; Lorena Salvatore; Daniela Melchiorri; Roberto Gradini; Andrea Caricasole; Eliana Barletta; Antonio De Blasi; Ferdinando Nicoletti
Native group-III metabotropic glutamate receptors are coupled to the mitogen-activated protein kinase/phosphatidylinositol-3-kinase pathways.
Journal of neurochemistry 2002;82(2):216-23.
2002: Gilbert Besong; Giuseppe Battaglia; Mara D'Onofrio; Roberto Di Marco; Richard Teke Ngomba; marianna storto; Marzia Castiglione; Katia Mangano; Carla L Busceti; Ferdinando R Nicoletti; Kevin Bacon; Michael Tusche; Ornella Valenti; P Jeffrey Conn; Valeria Bruno; Ferdinando Nicoletti
Activation of group III metabotropic glutamate receptors inhibits the production of RANTES in glial cell cultures.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2002;22(13):5403-11.
2002: Peter J Flor; Giuseppe Battaglia; Ferdinando Nicoletti; Fabrizio Gasparini; Valeria Bruno
Neuroprotective activity of metabotropic glutamate receptor ligands.
Advances in experimental medicine and biology 2002;513():197-223.
2001: Valeria Bruno; Giuseppe Battaglia; Agata Copani; Mara D'Onofrio; Patrizia Di Iorio; Antonio De Blasi; Daniela Melchiorri; Peter J Flor; Ferdinando Nicoletti
Metabotropic glutamate receptor subtypes as targets for neuroprotective drugs.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2001;21(9):1013-33.
2001: Mara D'Onofrio; Laura Cuomo; Giuseppe Battaglia; Richard Teke Ngomba; marianna storto; Ann E Kingston; Francesco Orzi; Antonio De Blasi; Patrizia Di Iorio; Ferdinando Nicoletti; Valeria Bruno
Neuroprotection mediated by glial group-II metabotropic glutamate receptors requires the activation of the MAP kinase and the phosphatidylinositol-3-kinase pathways.
Journal of neurochemistry 2001;78(3):435-45.
2001: Giuseppe Battaglia; Valeria Bruno; Antonio Pisani; Diego Centonze; Maria Vincenza Catania; Paolo Calabresi; Ferdinando Nicoletti
Selective blockade of type-1 metabotropic glutamate receptors induces neuroprotection by enhancing gabaergic transmission.
Molecular and cellular neurosciences 2001;17(6):1071-83.
2001: Daniela Melchiorri; Valeria Bruno; Gilbert Besong; Richard Teke Ngomba; Laura Cuomo; Antonio De Blasi; Agata Copani; CM Moschella; marianna storto; Ferdinando Nicoletti; G Lepperdinger; Francesca Passarelli
The mammalian homologue of the novel peptide Bv8 is expressed in the central nervous system and supports neuronal survival by activating the MAP kinase/PI-3-kinase pathways.
The European journal of neuroscience 2001;13(9):1694-702.
2001: Valeria Bruno; Giuseppe Battaglia; Agata Copani; V M Cespédes; Joaquin Jordan; Valentín Ceña; J Sánchez-Prieto; Fabrizio Gasparini; R Kuhn; Peter J Flor; Ferdinando Nicoletti
An activity-dependent switch from facilitation to inhibition in the control of excitotoxicity by group I metabotropic glutamate receptors.
The European journal of neuroscience 2001;13(8):1469-78.
2001: Agata Copani; Daniela Uberti; Maria Angela Sortino; Valeria Bruno; F Nicoletti; Maurizio Memo
Activation of cell-cycle-associated proteins in neuronal death: a mandatory or dispensable path?
Trends in neurosciences 2001;24(1):25-31.
2000: Valeria Bruno; I Ksiazek; Giuseppe Battaglia; Snezana Lukic; T Leonhardt; D Sauer; Fabrizio Gasparini; Rainer Kuhn; Ferdinando Nicoletti; Peter J Flor
Selective blockade of metabotropic glutamate receptor subtype 5 is neuroprotective.
Neuropharmacology 2000;39(12):2223-30.
2000: Valeria Bruno; Giuseppe Battaglia; I Ksiazek; Herman van der Putten; Maria Vincenza Catania; Raffaella Giuffrida; Snezana Lukic; T Leonhardt; Werner Inderbitzin; Fabrizio Gasparini; Rainer Kuhn; DR Hampson; Ferdinando Nicoletti; Peter J Flor
Selective activation of mGlu4 metabotropic glutamate receptors is protective against excitotoxic neuronal death.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2000;20(17):6413-20.
2000: Francesco Bonina; L Arenare; R Ippolito; Gianpiero Boatto; Giuseppe Battaglia; Valeria Bruno; Paolo De Caprariis
Synthesis, pharmacokinetics and anticonvulsant activity of 7-chlorokynurenic acid prodrugs.
International journal of pharmaceutics 2000;202(1-2):79-88.
2000: Valeria Bruno; Agata Copani; Gilbert Besong; G Scoto; Ferdinando Nicoletti
Neuroprotective activity of chemokines against N-methyl-D-aspartate or beta-amyloid-induced toxicity in culture.
European journal of pharmacology 2000;399(2-3):117-21.
2000: Giuseppe Battaglia; M La Russa; Valeria Bruno; L Arenare; R Ippolito; Agata Copani; Francesco Bonina; F Nicoletti
Systemically administered D-glucose conjugates of 7-chlorokynurenic acid are centrally available and exert anticonvulsant activity in rodents.
Brain research 2000;860(1-2):149-56.
1999: Ferdinando Nicoletti; Valeria Bruno; Maria Vincenza Catania; Giuseppe Battaglia; Agata Copani; Giuseppe M V Barbagallo; Valentín Ceña; J Sanchez-Prieto; PierFranco Spano; Marina Pizzi
Group-I metabotropic glutamate receptors: hypotheses to explain their dual role in neurotoxicity and neuroprotection.
Neuropharmacology 1999;38(10):1477-84.
1999: Renata Ciccarelli; Patrizia Di Iorio; Valeria Bruno; Giuseppe Battaglia; Iolanda D'Alimonte; Mara D'Onofrio; Ferdinando Nicoletti; Francesco Caciagli
Activation of A(1) adenosine or mGlu3 metabotropic glutamate receptors enhances the release of nerve growth factor and S-100beta protein from cultured astrocytes.
Glia 1999;27(3):275-81.
1999: Fabrizio Gasparini; Valeria Bruno; Giuseppe Battaglia; Snezana Lukic; T Leonhardt; Werner Inderbitzin; D Laurie; B Sommer; Mark A Varney; Stephen D Hess; Edwin Johnson; Rainer Kuhn; Stephan Urwyler; D Sauer; C Portet; Markus Schmutz; Ferdinando Nicoletti; Peter J Flor
(R,S)-4-phosphonophenylglycine, a potent and selective group III metabotropic glutamate receptor agonist, is anticonvulsive and neuroprotective in vivo.
The Journal of pharmacology and experimental therapeutics 1999;289(3):1678-87.
1999: Valeria Bruno; Giuseppe Battaglia; Ann E Kingston; M J O'Neill; Maria Vincenza Catania; R Di Grezia; Ferdinando Nicoletti
Neuroprotective activity of the potent and selective mGlu1a metabotropic glutamate receptor antagonist, (+)-2-methyl-4 carboxyphenylglycine (LY367385): comparison with LY357366, a broader spectrum antagonist with equal affinity for mGlu1a and mGlu5 receptors.
Neuropharmacology 1999;38(2):199-207.
1999: Ann E Kingston; Michael J O'Neill; A Bond; Valeria Bruno; Giuseppe Battaglia; F Nicoletti; J R Harris; Barry P Clark; James A Monn; David Lodge; Darryle D Schoepp
Neuroprotective actions of novel and potent ligands of group I and group II metabotropic glutamate receptors.
Annals of the New York Academy of Sciences 1999;890():438-49.
1998: Valeria Bruno; Giuseppe Battaglia; G Casabona; Agata Copani; Francesco Caciagli; Ferdinando Nicoletti
Neuroprotection by glial metabotropic glutamate receptors is mediated by transforming growth factor-beta.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1998;18(23):9594-600.
1998: Giuseppe Battaglia; Valeria Bruno; Richard Teke Ngomba; R Di Grezia; Agata Copani; Ferdinando Nicoletti
Selective activation of group-II metabotropic glutamate receptors is protective against excitotoxic neuronal death.
European journal of pharmacology 1998;356(2-3):271-4.
1998: Valeria Bruno; Barbara Wroblewska; Jarda T Wroblewski; L Fiore; Ferdinando Nicoletti
Neuroprotective activity of N-acetylaspartylglutamate in cultured cortical cells.
Neuroscience 1998;85(3):751-7.
1998: Agata Copani; G Casabona; Valeria Bruno; Alessandra Caruso; Daniele F Condorelli; Angela Messina; Valeria Di Giorgi Gerevini; J P Pin; R Kuhn; T Knöpfel; Ferdinando Nicoletti
The metabotropic glutamate receptor mGlu5 controls the onset of developmental apoptosis in cultured cerebellar neurons.
The European journal of neuroscience 1998;10(6):2173-84.
1998: Valeria Bruno; Giuseppe Battaglia; Agata Copani; G Casabona; marianna storto; Valeria Di Giorgi Gerevini; Richard Teke Ngomba; Ferdinando Nicoletti
Metabotropic glutamate receptors and neurodegeneration.
Progress in brain research 1998;116():209-21.
1997: FX Sureda; Agata Copani; Valeria Bruno; T Knöpfel; G Meltzger; Ferdinando Nicoletti
Metabotropic glutamate receptor agonists stimulate polyphosphoinositide hydrolysis in primary cultures of rat hepatocytes.
European journal of pharmacology 1997;338(2):R1-2.
1997: Valeria Bruno; FX Sureda; marianna storto; G Casabona; Alessandra Caruso; T Knopfel; R Kuhn; Ferdinando Nicoletti
The neuroprotective activity of group-II metabotropic glutamate receptors requires new protein synthesis and involves a glial-neuronal signaling.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1997;17(6):1891-7.
1996: Valeria Bruno; Agata Copani; L Bonanno; T Knoepfel; R Kuhn; P J Roberts; F Nicoletti
Activation of group III metabotropic glutamate receptors is neuroprotective in cortical cultures.
European journal of pharmacology 1996;310(1):61-6.
1996: L Bertino; M C Ruffini; Agata Copani; Valeria Bruno; G Raciti; A Cambria; Ferdinando Nicoletti
Growth conditions influence DNA methylation in cultured cerebellar granule cells.
Brain research. Developmental brain research 1996;95(1):38-43.
1996: Ferdinando Nicoletti; Valeria Bruno; Agata Copani; G Casabona; T Knöpfel
Metabotropic glutamate receptors: a new target for the therapy of neurodegenerative disorders?
Trends in neurosciences 1996;19(7):267-71.
1996: C Thomsen; Valeria Bruno; F Nicoletti; Maura Marinozzi; Roberto Pellicciari
(2S,1'S,2'S,3'R)-2-(2'-carboxy-3'-phenylcyclopropyl)glycine, a potent and selective antagonist of type 2 metabotropic glutamate receptors.
Molecular pharmacology 1996;50(1):6-9.
1996: Maura Marinozzi; Benedetto Natalini; Gabriele Costantino; Roberto Pellicciari; Valeria Bruno; F Nicoletti
Synthesis of 6,6-dicarboxy-3,4-methano-L-proline, a new constrained glutamate analog endowed with neuroprotective properties.
Farmaco (Società chimica italiana : 1989) 1996;51(2):121-4.
1996: Valeria Bruno; Agata Copani; Giuseppe Battaglia; Paola Dell'Albani; Daniele F Condorelli; Ferdinando Nicoletti
Metabotropic glutamate receptors and neuronal degeneration in culture.
Advances in neurology 1996;71():47-51, discussion 51-2.
1995: Valeria Bruno; Giuseppe Battaglia; Agata Copani; R G Giffard; G Raciti; Rocco Raffaele; H Shinozaki; Ferdinando Nicoletti
Activation of class II or III metabotropic glutamate receptors protects cultured cortical neurons against excitotoxic degeneration.
The European journal of neuroscience 1995;7(9):1906-13.
1995: Valeria Bruno; Agata Copani; T Knöpfel; Rainer Kuhn; G Casabona; Paola Dell'Albani; Daniele F Condorelli; Ferdinando Nicoletti
Activation of metabotropic glutamate receptors coupled to inositol phospholipid hydrolysis amplifies NMDA-induced neuronal degeneration in cultured cortical cells.
Neuropharmacology 1995;34(8):1089-98.
1995: Laura L Dugan; Valeria Bruno; S M Amagasu; Rona G Giffard
Glia modulate the response of murine cortical neurons to excitotoxicity: glia exacerbate AMPA neurotoxicity.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1995;15(6):4545-55.
1995: Valeria Bruno; Maria Angela Sortino; U Scapagnini; Ferdinando Nicoletti; Pier Luigi Canonico
Antidegenerative effects of Mg(2+)-valproate in cultured cerebellar neurons.
Functional neurology 1995;10(3):121-30.
1995: Agata Copani; Valeria Bruno; Giuseppe Battaglia; Giampiero Leanza; R Pellitteri; A Russo; Stefania Stanzani; Ferdinando Nicoletti
Activation of metabotropic glutamate receptors protects cultured neurons against apoptosis induced by beta-amyloid peptide.
Molecular pharmacology 1995;47(5):890-7.
1995: Agata Copani; Valeria Bruno; Paola Dell'Albani; Giuseppe Battaglia; Vincenza Barresi; Alessandra Caruso; Ferdinando Nicoletti; Daniele F Condorelli
Growth conditions differentially affect the constitutive expression of primary response genes in cultured cerebellar granule cells.
Neurochemical research 1995;20(5):611-6.
1995: Agata Copani; Valeria Bruno; Vincenza Barresi; Giuseppe Battaglia; Daniele F Condorelli; Ferdinando Nicoletti
Activation of metabotropic glutamate receptors prevents neuronal apoptosis in culture.
Journal of neurochemistry 1995;64(1):101-8.
1994: Valeria Bruno; Mark P Goldberg; Laura L Dugan; Rona G Giffard; Dennis Choi
Neuroprotective effect of hypothermia in cortical cultures exposed to oxygen-glucose deprivation or excitatory amino acids.
Journal of neurochemistry 1994;63(4):1398-406.
1994: Valeria Bruno; Giuseppe Battaglia; Agata Copani; Maria Angela Sortino; Pier Luigi Canonico; Ferdinando Nicoletti
Protective action of idebenone against excitotoxic degeneration in cultured cortical neurons.
Neuroscience letters 1994;178(2):193-6.
1994: Valeria Bruno; Agata Copani; Giuseppe Battaglia; Rocco Raffaele; H Shinozaki; Ferdinando Nicoletti
Protective effect of the metabotropic glutamate receptor agonist, DCG-IV, against excitotoxic neuronal death.
European journal of pharmacology 1994;256(1):109-12.
1993: Valeria Bruno; U Scapagnini; Pier Luigi Canonico
Excitatory amino acids and neurotoxicity.
Functional neurology 1993;8(4):279-92.
1992: G Casabona; Valeria Bruno; Maria Vincenza Catania; Maria Angela Sortino; Ferdinando Nicoletti; U Scapagnini; Pier Luigi Canonico
Thyrotropin releasing hormone (TRH) and its analog, RGH-2202, accelerate maturation of cerebellar neurons in vitro.
Brain research. Developmental brain research 1992;69(2):179-83.
1992: G Aleppo; A Pisani; Agata Copani; Valeria Bruno; E Aronica; Velia D'Agata; Pier Luigi Canonico; Ferdinando Nicoletti
Metabotropic glutamate receptors and neuronal toxicity.
Advances in experimental medicine and biology 1992;318():137-45.
1991: Agata Copani; G Raciti; Valeria Bruno; Maria Angela Sortino; Ferdinando Nicoletti; P L Canonico; A Cambria
Inositol hexakisphosphate stimulates 45Ca2+ influx in purified mitochondria from rat liver.
The Italian journal of biochemistry 1991;40(5):289-94.
1991: Agata Copani; Pier Luigi Canonico; Maria Vincenza Catania; E Aronica; Valeria Bruno; Emiliangelo Ratti; FT van Amsterdam; Giovanni Gaviraghi; Ferdinando Nicoletti
Interaction between beta-N-methylamino-L-alanine and excitatory amino acid receptors in brain slices and neuronal cultures.
Brain research 1991;558(1):79-86.
1990: Agata Copani; Valeria Bruno; Sebastiano Cavallaro; L Fiore; Maria Angela Sortino; Pier Luigi Canonico; Ferdinando Nicoletti
Receptors for inositolhexakisphosphate in neurons and anterior pituitary cells.
Pharmacological research : the official journal of the Italian Pharmacological Society 1990;22 Suppl 1():83-4.
1990: Ferdinando Nicoletti; Valeria Bruno; Sebastiano Cavallaro; Agata Copani; Maria Angela Sortino; Pier Luigi Canonico
Specific binding sites for inositolhexakisphosphate in brain and anterior pituitary.
Molecular pharmacology 1990;37(5):689-93.
1990: Pier Luigi Canonico; E Aronica; Valeria Bruno; Maria Vincenza Catania; G Aleppo; F Galavotti; Ferdinando Nicoletti
Pyrrolidone-carboxylic acid magnesium salt (PCA-Mg2+) protects against seizures induced by excitatory amino acids.
Functional neurology 1990;5(2):121-6.
1990: Ferdinando Nicoletti; G Magrì; F Ingrao; Valeria Bruno; Maria Vincenza Catania; Paola Dell'Albani; Daniele F Condorelli; R Avola
Excitatory amino acids stimulate inositol phospholipid hydrolysis and reduce proliferation in cultured astrocytes.
Journal of neurochemistry 1990;54(3):771-7.
1989: Ferdinando Nicoletti; Sebastiano Cavallaro; Valeria Bruno; Marco Virgili; Maria Vincenza Catania; Antonio Contestabile; Pier Luigi Canonico
Gangliosides attenuate NMDA receptor-mediated excitatory amino acid release in cultured cerebellar neurons.
Neuropharmacology 1989;28(11):1283-6.
1989: Ferdinando Nicoletti; Valeria Bruno; L Fiore; Sebastiano Cavallaro; Pier Luigi Canonico
Inositol hexakisphosphate (phytic acid) enhances Ca2+ influx and D-[3H]aspartate release in cultured cerebellar neurons.
Journal of neurochemistry 1989;53(4):1026-30.
1989: Daniele F Condorelli; F Ingrao; G Magri; Valeria Bruno; Ferdinando Nicoletti; R Avola
Activation of excitatory amino acid receptors reduces thymidine incorporation and cell proliferation rate in primary cultures of astrocytes.
Glia 1989;2(1):67-9.