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Hannele Yki-Järvinen

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Robert Bergholm; Antti Hakkarainen; Anna Kotronen; J Lundbom; Nina Lundbom; Aila Rissanen; A Santos; Ksenia Sevastianova; Mirja Tiikkainen; M Urjansson; Hannele Yki-Järvinen
CB1 blockade-induced weight loss over 48 weeks decreases liver fat in proportion to weight loss in humans.
S Lallukka; Nina Lundbom; Vesa M Olkkonen; Marju Orho-Melander; J Perttilä; Ksenia Sevastianova; Antti Hakkarainen; Hannele Yki-Järvinen
Adipose tissue is inflamed in NAFLD due to obesity but not in NAFLD due to genetic variation in PNPLA3.
Ingalill Rafter; Ina Schuppe-Koistinen; Lovisa Strömmer; Hannele Yki-Järvinen; Håkan B Andersson; Ian Cotgreave; Ewa Ehrenborg; Björn Ekblom; Truls Gråberg; Ray W Kim; Anna Kotronen; C Mikael Mattson; B Glinghammar
Isoform-specific alanine aminotransferase measurement can distinguish hepatic from extrahepatic injury in humans.

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All Publications

2013: Robert Bergholm; Antti Hakkarainen; Anna Kotronen; J Lundbom; Nina Lundbom; Aila Rissanen; A Santos; Ksenia Sevastianova; Mirja Tiikkainen; M Urjansson; Hannele Yki-Järvinen
CB1 blockade-induced weight loss over 48 weeks decreases liver fat in proportion to weight loss in humans.
International journal of obesity (2005) 2013;37(5):699-703.
2013: S Lallukka; Nina Lundbom; Vesa M Olkkonen; Marju Orho-Melander; J Perttilä; Ksenia Sevastianova; Antti Hakkarainen; Hannele Yki-Järvinen
Adipose tissue is inflamed in NAFLD due to obesity but not in NAFLD due to genetic variation in PNPLA3.
Diabetologia 2013;56(4):886-92.
2012: Ingalill Rafter; Ina Schuppe-Koistinen; Lovisa Strömmer; Hannele Yki-Järvinen; Håkan B Andersson; Ian Cotgreave; Ewa Ehrenborg; Björn Ekblom; Truls Gråberg; Ray W Kim; Anna Kotronen; C Mikael Mattson; B Glinghammar
Isoform-specific alanine aminotransferase measurement can distinguish hepatic from extrahepatic injury in humans.
International journal of molecular medicine 2012;30(5):1241-9.
2012: Ksenia Sevastianova; Kaisa Silander; Barbara A Fielding; Helena Gylling; Antti Hakkarainen; Anna Kotronen; Jesper Lundbom; Nina Lundbom; Janne Makkonen; Vesa M Olkkonen; Markku Peltonen; Aila Rissanen; Stefano Romeo; Alexandre Santos; Hannele Yki-Järvinen
Effect of short-term carbohydrate overfeeding and long-term weight loss on liver fat in overweight humans.
The American journal of clinical nutrition 2012;96(4):727-34.
2012: Tuulia Hyötyläinen; Artturi Koivuniemi; Ismo Mattila; Marja-Riitta Taskinen; Susanne K Wiedmer; Hannele Yki-Järvinen; Matej Oresic
Metabolomic analysis of polar metabolites in lipoprotein fractions identifies lipoprotein-specific metabolic profiles and their association with insulin resistance.
Molecular bioSystems 2012;8(10):2559-65.
2012: Outi Vaarala; Hannele Yki-Järvinen
Diabetes: Should we treat infection or inflammation to prevent T2DM?
Nature reviews. Endocrinology 2012;8(6):323-5.
2012: Julia Perttilä; Bart Staels; Kimmo Tanhuanpää; Hannele Yki-Järvinen; Sandrine Caron; Carolina Huaman-Samanez; Vesa M Olkkonen
PNPLA3 is regulated by glucose in human hepatocytes, and its I148M mutant slows down triglyceride hydrolysis.
American journal of physiology. Endocrinology and metabolism 2012;302(9):E1063-9.
2012: Jenni Hyysalo; Anna Kotronen; Ronald M Krauss; Nina Lundbom; Janne Makkonen; Olle Melander; Marju Orho-Melander; Aila Rissanen; Ksenia Sevastianova; Ivana Stojkovic; Antti Hakkarainen; Hannele Yki-Järvinen
Genetic variation in PNPLA3 but not APOC3 influences liver fat in non-alcoholic fatty liver disease.
Journal of gastroenterology and hepatology 2012;27(5):951-6.
2012: A J Varewijck; L J Hofland; J A M J L Janssen; S W J Lamberts; M Vähätalo; Hannele Yki-Järvinen
Addition of insulin glargine or NPH insulin to metformin monotherapy in poorly controlled type 2 diabetic patients decreases IGF-I bioactivity similarly.
Diabetologia 2012;55(4):1186-94.
2012: You Zhou; Marius R Robciuc; Martin Wabitsch; Hannele Yki-Järvinen; Christian Ehnholm; Anne Juuti; Marja Leivonen; Vesa M Olkkonen
OSBP-related proteins (ORPs) in human adipose depots and cultured adipocytes: evidence for impacts on the adipocyte phenotype.
PloS one 2012;7(9):e45352.
2012: Maria Kolak; Jan Liska; Matej Oresic; Scott A Summers; Jukka Westerbacka; Hannele Yki-Järvinen; Per Eriksson; Anders Franco-Cereceda; Joanna Gertow; Rachel M Fisher
Expression of ceramide-metabolising enzymes in subcutaneous and intra-abdominal human adipose tissue.
Lipids in health and disease 2012;11():115.
2012: Jarkko Soronen; Ida Surakka; Matti Jauhiainen; Pirkka-Pekka Laurila; Jussi Naukkarinen; Vesa M Olkkonen; Samuli Ripatti; Hannele Yki-Järvinen
Adipose tissue gene expression analysis reveals changes in inflammatory, mitochondrial respiratory and lipid metabolic pathways in obese insulin-resistant subjects.
BMC medical genomics 2012;5():9.
2012: Tina Landsvig Berentzen; Ronald Borra; Steven B Heymsfield; Patricia Iozzo; David Allison; Anna Kotronen; Pirjo Nuutila; Kim Overvad; Riitta Parkkola; Robert Ross; Thorkild I A Sørensen; Hannele Yki-Järvinen; Lars Ängquist; Marianne U Jakobsen
Waist circumference adjusted for body mass index and intra-abdominal fat mass.
PloS one 2012;7(2):e32213.
2012: Sanna M Kaye; Lotta Joutsi-Korhonen; Angela Silveira; Kirsi H Pietiläinen; Jaakko Kaprio; Anders Hamsten; Anna Kotronen; Hannele Yki-Järvinen; Riitta Lassila; Aila Rissanen
Obesity-related derangements of coagulation and fibrinolysis: a study of obesity-discordant monozygotic twin pairs.
Obesity (Silver Spring, Md.) 2012;20(1):88-94.
2011: Hannele Yki-Järvinen
Type 2 diabetes: remission in just a week.
Diabetologia 2011;54(10):2477-9.
2011: Mathijs C M Bunck; Anja Cornér; Bjorn Eliasson; Robert J Heine; Rimma M Shaginian; Ulf Smith; Marja-Riitta Taskinen; Hannele Yki-Järvinen; Michaela Diamant
Effects of exenatide on measures of β-cell function after 3 years in metformin-treated patients with type 2 diabetes.
Diabetes care 2011;34(9):2041-7.
2011: Anu Suomalainen; Mar Tulinius; Tiina Tyni; Johanna Uusimaa; Hannele Yki-Järvinen; Katrin Ounap; Johanna Annunen-Rasila; Laurence A Bindoff; Jana Buzkova; Niklas Darin; Jenni M Elo; Anna H Hakonen; Michio Hirano; Pirjo Isohanni; Sari Kiuru-Enari; Leo A J Kluijtmans; Mari Korpela; Sanna K Marjavaara; Anders Paetau; Kirsi H Pietiläinen; Helena Pihko; Aila Rissanen; Ksenia Sevastianova; Jan Smeitink; Henna Tyynismaa
FGF-21 as a biomarker for muscle-manifesting mitochondrial respiratory chain deficiencies: a diagnostic study.
Lancet neurology 2011;10(9):806-18.
2011: Ksenia Sevastianova; Meline Sievers; Jussi Sutinen; Dick Wågsäter; Ulrich A Walker; Petri Auvinen; Sven Enerbäck; Per Eriksson; Dario Greco; Martin E Lidell; Vesa M Olkkonen; Julia Perttilä; Matti Ristola; Kaisa Salmenkivi; Hannele Yki-Järvinen
Comparison of dorsocervical with abdominal subcutaneous adipose tissue in patients with and without antiretroviral therapy-associated lipodystrophy.
Diabetes 2011;60(7):1894-900.
2011: Ksenia Sevastianova; Laura Suojanen; Eleuterio Ferrannini; Amalia Gastaldelli; Antti Hakkarainen; Anna Kotronen; Jesper Lundbom; Nina Lundbom; Vesa M Olkkonen; Marju Orho-Melander; Julia Perttilä; Aila Rissanen; Hannele Yki-Järvinen
Genetic variation in PNPLA3 (adiponutrin) confers sensitivity to weight loss-induced decrease in liver fat in humans.
The American journal of clinical nutrition 2011;94(1):104-11.
2011: Kirsi H Pietiläinen; Aila Rissanen; Sergio Rodriguez-Cuenca; Tomasz Róg; Anna-Liisa Ruskeepää; Tuulikki Seppänen-Laakso; Chong Yew Tan; Jing Tang; Ilpo Vattulainen; Vidya Velagapudi; antonio vidal-puig; Sam Virtue; Laxman Yetukuri; Hannele Yki-Järvinen; Sandra Castillo; Peddinti Gopalacharyulu; Tuulia Hyötyläinen; Jaakko Kaprio; Arkadiusz Maciejewski; Jussi Naukkarinen; Perttu S Niemelä; Heli Nygren; Matej Orešič
Association of lipidome remodeling in the adipocyte membrane with acquired obesity in humans.
PLoS biology 2011;9(6):e1000623.
2011: Mathijs C M Bunck; B Eliasson; Anja Cornér; Robert J Heine; R M Shaginian; Marja-Riitta Taskinen; Hannele Yki-Järvinen; U Smith; Michaela Diamant
Exenatide treatment did not affect bone mineral density despite body weight reduction in patients with type 2 diabetes.
Diabetes, obesity & metabolism 2011;13(4):374-7.
2011: Anna Kotronen; Lotta Joutsi-Korhonen; Ksenia Sevastianova; Robert Bergholm; Antti Hakkarainen; Kirsi H Pietiläinen; Nina Lundbom; Aila Rissanen; Riitta Lassila; Hannele Yki-Järvinen
Increased coagulation factor VIII, IX, XI and XII activities in non-alcoholic fatty liver disease.
Liver international : official journal of the International Association for the Study of the Liver 2011;31(2):176-83.
2011: Piia P Simonen; Anna Kotronen; Merja Hallikainen; Ksenia Sevastianova; Janne Makkonen; Antti Hakkarainen; Nina Lundbom; Tatu A Miettinen; Helena Gylling; Hannele Yki-Järvinen
Cholesterol synthesis is increased and absorption decreased in non-alcoholic fatty liver disease independent of obesity.
Journal of hepatology 2011;54(1):153-9.
2011: Anna Kotronen; Hannele Yki-Järvinen; Ksenia Sevastianova; Robert Bergholm; Antti Hakkarainen; Kirsi H Pietiläinen; Leena Juurinen; Nina Lundbom; Thorkild I A Sørensen
Comparison of the relative contributions of intra-abdominal and liver fat to components of the metabolic syndrome.
Obesity (Silver Spring, Md.) 2011;19(1):23-8.
2010: Jukka Westerbacka; Anna Kotronen; Barbara A Fielding; John Wahren; Leanne Hodson; Julia Perttilä; Tuulikki Seppänen-Laakso; Tapani Suortti; Johanna Arola; Rolf Hultcrantz; Sandra Castillo; Vesa M Olkkonen; Keith N Frayn; Matej Orešič; Hannele Yki-Järvinen
Splanchnic balance of free fatty acids, endocannabinoids, and lipids in subjects with nonalcoholic fatty liver disease.
Gastroenterology 2010;139(6):1961-1971.e1.
2010: Hannele Yki-Järvinen
Nutritional modulation of nonalcoholic fatty liver disease and insulin resistance: human data.
Current opinion in clinical nutrition and metabolic care 2010;13(6):709-14.
2010: Mathijs C M Bunck; Anja Cornér; Bjorn Eliasson; Robert J Heine; Rimma M Shaginian; Yan Wu; Ping Yan; Ulf Smith; Hannele Yki-Järvinen; Michaela Diamant; Marja-Riitta Taskinen
One-year treatment with exenatide vs. insulin glargine: effects on postprandial glycemia, lipid profiles, and oxidative stress.
Atherosclerosis 2010;212(1):223-9.
2010: Ksenia Sevastianova; Antti Hakkarainen; Anna Kotronen; Anja Cornér; Perttu Arkkila; Johanna Arola; Jukka Westerbacka; Robert Bergholm; Jesper Lundbom; Nina Lundbom; Hannele Yki-Järvinen
Nonalcoholic fatty liver disease: detection of elevated nicotinamide adenine dinucleotide phosphate with in vivo 3.0-T 31P MR spectroscopy with proton decoupling.
Radiology 2010;256(2):466-73.
2010: Mathijs C M Bunck; Michaela Diamant; Bjorn Eliasson; Anja Cornér; Rimma M Shaginian; Robert J Heine; Marja-Riitta Taskinen; Hannele Yki-Järvinen; Ulf Smith
Exenatide affects circulating cardiovascular risk biomarkers independently of changes in body composition.
Diabetes care 2010;33(8):1734-7.
2010: Jussi Sutinen; Marko S Laaksonen; Ulrich A Walker; Bernhard Setzer; Jukka Kemppainen; Pirjo Nuutila; Hannele Yki-Järvinen
Skeletal muscle mitochondrial DNA content and aerobic metabolism in patients with antiretroviral therapy-associated lipoatrophy.
The Journal of antimicrobial chemotherapy 2010;65(7):1497-504.
2010: Jussi Naukkarinen; Ida Surakka; Kirsi H Pietiläinen; Aila Rissanen; Veikko Salomaa; Samuli Ripatti; Hannele Yki-Järvinen; Cornelia M van Duijn; H-Erich Wichmann; Jaakko Kaprio; Marja-Riitta Taskinen; Leena Peltonen
Use of genome-wide expression data to mine the "Gray Zone" of GWA studies leads to novel candidate obesity genes.
PLoS genetics 2010;6(6):e1000976.
2010: Ester Vanni; Elisabetta Bugianesi; Anna Kotronen; Samuele De Minicis; Hannele Yki-Järvinen; Gianluca Svegliati-Baroni
From the metabolic syndrome to NAFLD or vice versa?
Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver 2010;42(5):320-30.
2010: Anna Kotronen; Tuulikki Seppänen-Laakso; Jukka Westerbacka; Tuula Kiviluoto; Johanna Arola; Anna-Liisa Ruskeepää; Hannele Yki-Järvinen; Matej Oresic
Comparison of lipid and fatty acid composition of the liver, subcutaneous and intra-abdominal adipose tissue, and serum.
Obesity (Silver Spring, Md.) 2010;18(5):937-44.
2010: Kirsi H Pietiläinen; Maarit Korkeila; L H Bogl; Klaas R Westerterp; Hannele Yki-Järvinen; Jaakko Kaprio; Aila Rissanen
Inaccuracies in food and physical activity diaries of obese subjects: complementary evidence from doubly labeled water and co-twin assessments.
International journal of obesity (2005) 2010;34(3):437-45.
2010: Tina Vilsbøll; J Rosenstock; Hannele Yki-Järvinen; W T Cefalu; Y Chen; E Luo; B Musser; P J Andryuk; Y Ling; K D Kaufman; J M Amatruda; S S Engel; L Katz
Efficacy and safety of sitagliptin when added to insulin therapy in patients with type 2 diabetes.
Diabetes, obesity & metabolism 2010;12(2):167-77.
2010: Hannele Yki-Järvinen
Liver fat in the pathogenesis of insulin resistance and type 2 diabetes.
Digestive diseases (Basel, Switzerland) 2010;28(1):203-9.
2010: Anna Kotronen; Hannele Yki-Järvinen; Satu Männistö; Liisa Saarikoski; Eeva Korpi-Hyövälti; Heikki Oksa; Juha Saltevo; Timo Saaristo; Jouko Sundvall; Jaakko Tuomilehto; Markku Peltonen
Non-alcoholic and alcoholic fatty liver disease - two diseases of affluence associated with the metabolic syndrome and type 2 diabetes: the FIN-D2D survey.
BMC public health 2010;10():237.
2010: Anna Aminoff; Helena Ledmyr; Petra Thulin; Kerstin Lundell; Leyla Nunez; Elisabeth Strandhagen; Charlotte Murphy; Ulf Lidberg; Jukka Westerbacka; Anders Franco-Cereceda; Jan Liska; Lars Bo Nielsen; Mats Gåfvels; Maria Nastase Mannila; Anders Hamsten; Hannele Yki-Järvinen; Dag Thelle; Per Eriksson; Jan Borén; Ewa Ehrenborg
Allele-specific regulation of MTTP expression influences the risk of ischemic heart disease.
Journal of lipid research 2010;51(1):103-11.
2009: Hannele Yki-Järvinen
Thiazolidinediones and the liver in humans.
Current opinion in lipidology 2009;20(6):477-83.
2009: Anna Kotronen; Anneli Seppälä-Lindroos; Satu Vehkavaara; Robert Bergholm; Keith N Frayn; Barbara A Fielding; Hannele Yki-Järvinen
Liver fat and lipid oxidation in humans.
Liver international : official journal of the International Association for the Study of the Liver 2009;29(9):1439-46.
2009: Anna Kotronen; Markku Peltonen; Antti Hakkarainen; Ksenia Sevastianova; Robert Bergholm; Lina M Johansson; Nina Lundbom; Aila Rissanen; Martin Ridderstråle; Leif Groop; Marju Orho-Melander; Hannele Yki-Järvinen
Prediction of non-alcoholic fatty liver disease and liver fat using metabolic and genetic factors.
Gastroenterology 2009;137(3):865-72.
2009: M Sievers; Ulrich A Walker; K Sevastianova; Bernhard Setzer; Dick Wågsäter; P Eriksson; Hannele Yki-Järvinen; J Sutinen
Gene expression and immunohistochemistry in adipose tissue of HIV type 1-infected patients with nucleoside analogue reverse-transcriptase inhibitor-associated lipoatrophy.
The Journal of infectious diseases 2009;200(2):252-62.
2009: Anna Kotronen; L E Johansson; L M Johansson; C Roos; Jukka Westerbacka; Anders Hamsten; Robert Bergholm; Perttu E T Arkkila; J Arola; Tuula Kiviluoto; Rachel M Fisher; Ewa Ehrenborg; Marju Orho-Melander; M Ridderstråle; Leif Groop; Hannele Yki-Järvinen
A common variant in PNPLA3, which encodes adiponutrin, is associated with liver fat content in humans.
Diabetologia 2009;52(6):1056-60.
2009: Janne Makkonen; Kirsi H Pietiläinen; Aila Rissanen; Jaakko Kaprio; Hannele Yki-Järvinen
Genetic factors contribute to variation in serum alanine aminotransferase activity independent of obesity and alcohol: a study in monozygotic and dizygotic twins.
Journal of hepatology 2009;50(5):1035-42.
2009: Mathijs C M Bunck; Michaela Diamant; Anja Cornér; Bjorn Eliasson; Jaret L Malloy; Rimma M Shaginian; Wei Deng; David M Kendall; Marja-Riitta Taskinen; Ulf Smith; Hannele Yki-Järvinen; Robert J Heine
One-year treatment with exenatide improves beta-cell function, compared with insulin glargine, in metformin-treated type 2 diabetic patients: a randomized, controlled trial.
Diabetes care 2009;32(5):762-8.
2009: L Juurinen; M Tiikkainen; J Saltevo; K Nikkilä; H Lanki; E Leppävuori; T Kock; T Teikari-Myyrä; Ritva Kauppinen-Mäkelin; Anna Kotronen; Hannele Yki-Järvinen
Nateglinide combination therapy with basal insulin and metformin in patients with Type 2 diabetes.
Diabetic medicine : a journal of the British Diabetic Association 2009;26(4):409-15.
2009: Anna Kotronen; V R Velagapudi; L Yetukuri; Jukka Westerbacka; Robert Bergholm; K Ekroos; Janne Makkonen; Marja-Riitta Taskinen; Matej Oresic; Hannele Yki-Järvinen
Serum saturated fatty acids containing triacylglycerols are better markers of insulin resistance than total serum triacylglycerol concentrations.
Diabetologia 2009;52(4):684-90.
2009: Anna Kotronen; Hannele Yki-Järvinen; Anna Aminoff; Robert Bergholm; Kirsi H Pietiläinen; Jukka Westerbacka; Philippa J Talmud; Steve E Humphries; Anders Hamsten; Bo Isomaa; Leif Groop; Marju Orho-Melander; Ewa Ehrenborg; Rachel M Fisher
Genetic variation in the ADIPOR2 gene is associated with liver fat content and its surrogate markers in three independent cohorts.
European journal of endocrinology / European Federation of Endocrine Societies 2009;160(4):593-602.
2009: Saara Tikka; Kati Mykkänen; Marie-Magdeleine Ruchoux; Robert Bergholm; Maija Junna; Minna Pöyhönen; Hannele Yki-Järvinen; Anne Joutel; Matti Viitanen; Marc Baumann; Hannu Kalimo
Congruence between NOTCH3 mutations and GOM in 131 CADASIL patients.
Brain : a journal of neurology 2009;132(Pt 4):933-9.
2009: Anna Kotronen; Tuulikki Seppänen-Laakso; Jukka Westerbacka; Tuula Kiviluoto; Johanna Arola; Anna-Liisa Ruskeepää; Matej Oresic; Hannele Yki-Järvinen
Hepatic stearoyl-CoA desaturase (SCD)-1 activity and diacylglycerol but not ceramide concentrations are increased in the nonalcoholic human fatty liver.
Diabetes 2009;58(1):203-8.
2008: Anne Hiukka; Jukka Westerbacka; Eeva S Leinonen; Hiroshi Watanabe; Olov Wiklund; Lillemor Mattson Hulten; Jukka T Salonen; Tomi-Pekka Tuomainen; Hannele Yki-Järvinen; Anthony C Keech; Marja-Riitta Taskinen
Long-term effects of fenofibrate on carotid intima-media thickness and augmentation index in subjects with type 2 diabetes mellitus.
Journal of the American College of Cardiology 2008;52(25):2190-7.
2008: Anna Kotronen; Moira Lewitt; Kerstin Hall; Kerstin Brismar; Hannele Yki-Järvinen
Insulin-like growth factor binding protein 1 as a novel specific marker of hepatic insulin sensitivity.
The Journal of clinical endocrinology and metabolism 2008;93(12):4867-72.
2008: Anna Kotronen; Leena Juurinen; Mirja Tiikkainen; Satu Vehkavaara; Hannele Yki-Järvinen
Increased liver fat, impaired insulin clearance, and hepatic and adipose tissue insulin resistance in type 2 diabetes.
Gastroenterology 2008;135(1):122-30.
2008: Linda Mustelin; Kirsi H Pietiläinen; Aila Rissanen; Anssi R Sovijärvi; Päivi Piirilä; Jussi Naukkarinen; Leena Peltonen; Jaakko Kaprio; Hannele Yki-Järvinen
Acquired obesity and poor physical fitness impair expression of genes of mitochondrial oxidative phosphorylation in monozygotic twins discordant for obesity.
American journal of physiology. Endocrinology and metabolism 2008;295(1):E148-54.
2008: Ksenia Sevastianova; Jussi Sutinen; Katja Kannisto; Anders Hamsten; Matti Ristola; Hannele Yki-Järvinen
Adipose tissue inflammation and liver fat in patients with highly active antiretroviral therapy-associated lipodystrophy.
American journal of physiology. Endocrinology and metabolism 2008;295(1):E85-91.
2008: Dario Greco; Anna Kotronen; Jukka Westerbacka; Oscar Puig; Perttu Arkkila; Tuula Kiviluoto; Saara Laitinen; Maria Kolak; Rachel M Fisher; Anders Hamsten; Petri Auvinen; Hannele Yki-Järvinen
Gene expression in human NAFLD.
American journal of physiology. Gastrointestinal and liver physiology 2008;294(5):G1281-7.
2008: Jukka Westerbacka; Anja Cornér; Maria Kolak; Janne Makkonen; Ursula Turpeinen; Anders Hamsten; Rachel M Fisher; Hannele Yki-Järvinen
Insulin regulation of MCP-1 in human adipose tissue of obese and lean women.
American journal of physiology. Endocrinology and metabolism 2008;294(5):E841-5.
2008: Kirsi H Pietiläinen; Jussi Naukkarinen; Aila Rissanen; Juha Saharinen; Pekka Ellonen; Heli Keränen; Anu Suomalainen; Alexandra Götz; Tapani Suortti; Hannele Yki-Järvinen; Matej Oresic; Jaakko Kaprio; Leena Peltonen
Global transcript profiles of fat in monozygotic twins discordant for BMI: pathways behind acquired obesity.
PLoS medicine 2008;5(3):e51.
2008: Kirsi H Pietiläinen; Jaakko Kaprio; Patrik Borg; Guy Plasqui; Hannele Yki-Järvinen; Urho M Kujala; Richard J Rose; Klaas R Westerterp; Aila Rissanen
Physical inactivity and obesity: a vicious circle.
Obesity (Silver Spring, Md.) 2008;16(2):409-14.
2008: Anna Kotronen; Anneli Seppälä-Lindroos; Robert Bergholm; Hannele Yki-Järvinen
Tissue specificity of insulin resistance in humans: fat in the liver rather than muscle is associated with features of the metabolic syndrome.
Diabetologia 2008;51(1):130-8.
2008: Leena Juurinen; Anna Kotronen; Marit Granér; Hannele Yki-Järvinen
Rosiglitazone reduces liver fat and insulin requirements and improves hepatic insulin sensitivity and glycemic control in patients with type 2 diabetes requiring high insulin doses.
The Journal of clinical endocrinology and metabolism 2008;93(1):118-24.
2008: Anna Kotronen; Leena Juurinen; Antti Hakkarainen; Jukka Westerbacka; Anja Cornér; Robert Bergholm; Hannele Yki-Järvinen
Liver fat is increased in type 2 diabetic patients and underestimated by serum alanine aminotransferase compared with equally obese nondiabetic subjects.
Diabetes care 2008;31(1):165-9.
2008: Anna Kotronen; Hannele Yki-Järvinen
Fatty liver: a novel component of the metabolic syndrome.
Arteriosclerosis, thrombosis, and vascular biology 2008;28(1):27-38.
2007: Anna Kotronen; Satu Vehkavaara; Anneli Seppälä-Lindroos; Robert Bergholm; Hannele Yki-Järvinen
Effect of liver fat on insulin clearance.
American journal of physiology. Endocrinology and metabolism 2007;293(6):E1709-15.
2007: Martin Adiels; Jukka Westerbacka; Aino Soro-Paavonen; Anna-Maija Häkkinen; Satu Vehkavaara; Muriel J Caslake; Chris Packard; Sven-Olof Olofsson; Hannele Yki-Järvinen; Marja-Riitta Taskinen; Jan Borén
Acute suppression of VLDL1 secretion rate by insulin is associated with hepatic fat content and insulin resistance.
Diabetologia 2007;50(11):2356-65.
2007: Jukka Westerbacka; Maria Kolak; Tuula Kiviluoto; Perttu Arkkila; Jukka Sirén; Anders Hamsten; Rachel M Fisher; Hannele Yki-Järvinen
Genes involved in fatty acid partitioning and binding, lipolysis, monocyte/macrophage recruitment, and inflammation are overexpressed in the human fatty liver of insulin-resistant subjects.
Diabetes 2007;56(11):2759-65.
2007: Janne Makkonen; Jukka Westerbacka; Maria Kolak; Jussi Sutinen; Anja Cornér; Anders Hamsten; Rachel M Fisher; Hannele Yki-Järvinen
Increased expression of the macrophage markers and of 11beta-HSD-1 in subcutaneous adipose tissue, but not in cultured monocyte-derived macrophages, is associated with liver fat in human obesity.
International journal of obesity (2005) 2007;31(10):1617-25.
2007: Anna Kotronen; Jukka Westerbacka; Robert Bergholm; Kirsi H Pietiläinen; Hannele Yki-Järvinen
Liver fat in the metabolic syndrome.
The Journal of clinical endocrinology and metabolism 2007;92(9):3490-7.
2007: Maria Kolak; Jukka Westerbacka; Vidya R Velagapudi; Dick Wågsäter; Laxman Yetukuri; Janne Makkonen; Aila Rissanen; Anna-Maija Häkkinen; Monica Lindell; Robert Bergholm; Anders Hamsten; Per Eriksson; Rachel M Fisher; Matej Oresic; Hannele Yki-Järvinen
Adipose tissue inflammation and increased ceramide content characterize subjects with high liver fat content independent of obesity.
Diabetes 2007;56(8):1960-8.
2007: Niina Matikainen; Sakari Mänttäri; Jukka Westerbacka; Satu Vehkavaara; Nina Lundbom; Hannele Yki-Järvinen; Marja-Riitta Taskinen
Postprandial lipemia associates with liver fat content.
The Journal of clinical endocrinology and metabolism 2007;92(8):3052-9.
2007: Marko Sysi-Aho; Aki Vehtari; Vidya R Velagapudi; Jukka Westerbacka; Laxman Yetukuri; Robert Bergholm; Marja-Riitta Taskinen; Hannele Yki-Järvinen; Matej Oresic
Exploring the lipoprotein composition using Bayesian regression on serum lipidomic profiles.
Bioinformatics (Oxford, England) 2007;23(13):i519-28.
2007: Hannele Yki-Järvinen; Leena Juurinen; Michael Alvarsson; Tord Bystedt; Ian Caldwell; Melanie Davies; Sanni Lahdenperä; Gil Nijpels; Markku Vähätalo
Initiate Insulin by Aggressive Titration and Education (INITIATE): a randomized study to compare initiation of insulin combination therapy in type 2 diabetic patients individually and in groups.
Diabetes care 2007;30(6):1364-9.
2007: Leena Juurinen; Mirja Tiikkainen; Anna-Maija Häkkinen; Antti Hakkarainen; Hannele Yki-Järvinen
Effects of insulin therapy on liver fat content and hepatic insulin sensitivity in patients with type 2 diabetes.
American journal of physiology. Endocrinology and metabolism 2007;292(3):E829-35.
2007: Jussi Sutinen; Hannele Yki-Järvinen
Increased resting energy expenditure, fat oxidation, and food intake in patients with highly active antiretroviral therapy-associated lipodystrophy.
American journal of physiology. Endocrinology and metabolism 2007;292(3):E687-92.
2007: Maria Kolak; Hannele Yki-Järvinen; Katja Kannisto; Mirja Tiikkainen; Anders Hamsten; Per Eriksson; Rachel M Fisher
Effects of chronic rosiglitazone therapy on gene expression in human adipose tissue in vivo in patients with type 2 diabetes.
The Journal of clinical endocrinology and metabolism 2007;92(2):720-4.
2007: Jussi Sutinen; Ulrich A Walker; Ksenia Sevastianova; Hartwig Klinker; Anna-Maija Häkkinen; Matti Ristola; Hannele Yki-Järvinen
Uridine supplementation for the treatment of antiretroviral therapy-associated lipoatrophy: a randomized, double-blind, placebo-controlled trial.
Antiviral therapy 2007;12(1):97-105.
2007: Kirsi H Pietiläinen; Marko Sysi-Aho; Aila Rissanen; Tuulikki Seppänen-Laakso; Hannele Yki-Järvinen; Jaakko Kaprio; Matej Oresic
Acquired obesity is associated with changes in the serum lipidomic profile independent of genetic effects--a monozygotic twin study.
PloS one 2007;2(2):e218.
2007: Hannele Yki-Järvinen; Jukka Westerbacka
Insulin resistance, arterial stiffness and wave reflection.
Advances in cardiology 2007;44():252-60.
2006: Kirsi H Pietiläinen; Katja Kannisto; Elena Korsheninnikova; Aila Rissanen; Jaakko Kaprio; Ewa Ehrenborg; Anders Hamsten; Hannele Yki-Järvinen
Acquired obesity increases CD68 and tumor necrosis factor-alpha and decreases adiponectin gene expression in adipose tissue: a study in monozygotic twins.
The Journal of clinical endocrinology and metabolism 2006;91(7):2776-81.
2006: Kirsi H Pietiläinen; Robert Bergholm; Aila Rissanen; Jaakko Kaprio; Anna-Maija Häkkinen; Naveed Sattar; Hannele Yki-Järvinen
Effects of acquired obesity on endothelial function in monozygotic twins.
Obesity (Silver Spring, Md.) 2006;14(5):826-37.
2006: Martin Adiels; Marja-Riitta Taskinen; Chris Packard; Muriel J Caslake; Aino Soro-Paavonen; Jukka Westerbacka; Satu Vehkavaara; A Häkkinen; Sven-Olof Olofsson; Hannele Yki-Järvinen; Jan Borén
Overproduction of large VLDL particles is driven by increased liver fat content in man.
Diabetologia 2006;49(4):755-65.
2006: Hannele Yki-Järvinen; R Kauppinen-Mäkelin; Mirja Tiikkainen; M Vähätalo; H Virtamo; K Nikkilä; Timo Tulokas; S Hulme; K Hardy; S McNulty; J Hänninen; H Levänen; Sanni Lahdenperä; Rainer Lehtonen; L Ryysy
Insulin glargine or NPH combined with metformin in type 2 diabetes: the LANMET study.
Diabetologia 2006;49(3):442-51.
2006: Keith N Frayn; Peter Arner; Hannele Yki-Järvinen
Fatty acid metabolism in adipose tissue, muscle and liver in health and disease.
Essays in biochemistry 2006;42():89-103.
2006: Jukka Westerbacka; Anja Cornér; Katja Kannisto; Maria Kolak; Janne Makkonen; Elena Korsheninnikova; Tuulikki Nyman; Anders Hamsten; Rachel M Fisher; Hannele Yki-Järvinen
Acute in vivo effects of insulin on gene expression in adipose tissue in insulin-resistant and insulin-sensitive subjects.
Diabetologia 2006;49(1):132-40.
2005: Hannele Yki-Järvinen
The PROactive study: some answers, many questions.
Lancet 2005;366(9493):1241-2.
2005: Jukka Westerbacka; Eeva Leinonen; Jukka T Salonen; Riitta Salonen; Anne Hiukka; Hannele Yki-Järvinen; Marja-Riitta Taskinen
Increased augmentation of central blood pressure is associated with increases in carotid intima-media thickness in type 2 diabetic patients.
Diabetologia 2005;48(8):1654-62.
2005: Hannele Yki-Järvinen; Jukka Westerbacka
The fatty liver and insulin resistance.
Current molecular medicine 2005;5(3):287-95.
2005: Ruth Andrew; Jukka Westerbacka; John Wahren; Hannele Yki-Järvinen; Brian R Walker
The contribution of visceral adipose tissue to splanchnic cortisol production in healthy humans.
Diabetes 2005;54(5):1364-70.
2005: Markku Seppala; Erik Mandelin; Riitta Koistinen; Robert Bergholm; Mirja Tiikkainen; Hannele Yki-Järvinen
Glycodelin responses to hyperinsulinaemic clamp vary according to basal serum glycodelin concentration.
Clinical endocrinology 2005;62(5):611-5.
2005: Jukka Westerbacka; Katriina Lammi; Anna-Maija Häkkinen; Aila Rissanen; Irma Salminen; Antti Aro; Hannele Yki-Järvinen
Dietary fat content modifies liver fat in overweight nondiabetic subjects.
The Journal of clinical endocrinology and metabolism 2005;90(5):2804-9.
2005: Kirsi H Pietiläinen; Aila Rissanen; Jaakko Kaprio; Sari Mäkimattila; Anna-Maija Häkkinen; Jukka Westerbacka; Jussi Sutinen; Satu Vehkavaara; Hannele Yki-Järvinen
Acquired obesity is associated with increased liver fat, intra-abdominal fat, and insulin resistance in young adult monozygotic twins.
American journal of physiology. Endocrinology and metabolism 2005;288(4):E768-74.
2005: Hans U Janka; Gerd Plewe; Matthew C Riddle; Christine Kliebe-Frisch; Matthias A Schweitzer; Hannele Yki-Järvinen
Comparison of basal insulin added to oral agents versus twice-daily premixed insulin as initial insulin therapy for type 2 diabetes.
Diabetes care 2005;28(2):254-9.
2005: Ksenia Sevastianova; Jussi Sutinen; Jukka Westerbacka; Matti Ristola; Hannele Yki-Järvinen
Arterial stiffness in HIV-infected patients receiving highly active antiretroviral therapy.
Antiviral therapy 2005;10(8):925-35.
2005: Hannele Yki-Järvinen
Fat in the liver and insulin resistance.
Annals of medicine 2005;37(5):347-56.
2004: Sari Mäkimattila; Kirsi Malmberg-Cèder; Anna-Maija Häkkinen; Kim Vuori; Oili Salonen; Paula Summanen; Hannele Yki-Järvinen; Markku Kaste; Sami Heikkinen; Nina Lundbom; Risto O Roine
Brain metabolic alterations in patients with type 1 diabetes-hyperglycemia-induced injury.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2004;24(12):1393-9.
2004: Kirsi H Pietiläinen; Aila Rissanen; Maria Laamanen; Anna-Kaisa Lindholm; Harri Markkula; Hannele Yki-Järvinen; Jaakko Kaprio
Growth patterns in young adult monozygotic twin pairs discordant and concordant for obesity.
Twin research : the official journal of the International Society for Twin Studies 2004;7(5):421-9.
2004: Jussi Sutinen; Katja Kannisto; Elena Korsheninnikova; Tuulikki Nyman; Ewa Ehrenborg; Ruth Andrew; Deborah J Wake; Anders Hamsten; Brian R Walker; Hannele Yki-Järvinen
In the lipodystrophy associated with highly active antiretroviral therapy, pseudo-Cushing's syndrome is associated with increased regeneration of cortisol by 11beta-hydroxysteroid dehydrogenase type 1 in adipose tissue.
Diabetologia 2004;47(10):1668-71.
2004: Hannele Yki-Järvinen
Thiazolidinediones.
The New England journal of medicine 2004;351(11):1106-18.
2004: Katja Kannisto; Kirsi H Pietiläinen; Ewa Ehrenborg; Aila Rissanen; Jaakko Kaprio; Anders Hamsten; Hannele Yki-Järvinen
Overexpression of 11beta-hydroxysteroid dehydrogenase-1 in adipose tissue is associated with acquired obesity and features of insulin resistance: studies in young adult monozygotic twins.
The Journal of clinical endocrinology and metabolism 2004;89(9):4414-21.
2004: Jukka Westerbacka; Anja Cornér; Mirja Tiikkainen; Marjo Tamminen; Satu Vehkavaara; Anna-Maija Häkkinen; J Fredriksson; Hannele Yki-Järvinen
Women and men have similar amounts of liver and intra-abdominal fat, despite more subcutaneous fat in women: implications for sex differences in markers of cardiovascular risk.
Diabetologia 2004;47(8):1360-9.
2004: Mirja Tiikkainen; Anna-Maija Häkkinen; Elena Korsheninnikova; Tuulikki Nyman; Sari Mäkimattila; Hannele Yki-Järvinen
Effects of rosiglitazone and metformin on liver fat content, hepatic insulin resistance, insulin clearance, and gene expression in adipose tissue in patients with type 2 diabetes.
Diabetes 2004;53(8):2169-76.
2004: Hannele Yki-Järvinen
Insulin therapy in type 2 diabetes: role of the long-acting insulin glargine analogue.
European journal of clinical investigation 2004;34(6):410-6.
2004: Karl Gertow; K H Pietiläinen; Hannele Yki-Järvinen; Jaakko Kaprio; Aila Rissanen; Per Eriksson; Anders Hamsten; Rachel M Fisher
Expression of fatty-acid-handling proteins in human adipose tissue in relation to obesity and insulin resistance.
Diabetologia 2004;47(6):1118-25.
2004: Jussi Sutinen; Katja Kannisto; Elena Korsheninnikova; Rachel M Fisher; Ewa Ehrenborg; Tuulikki Nyman; Antti Virkamäki; Tohru Funahashi; Yuji Matsuzawa; Hubert Vidal; Anders Hamsten; Hannele Yki-Järvinen
Effects of rosiglitazone on gene expression in subcutaneous adipose tissue in highly active antiretroviral therapy-associated lipodystrophy.
American journal of physiology. Endocrinology and metabolism 2004;286(6):E941-9.
2004: Satu Vehkavaara; Hannele Yki-Järvinen
3.5 years of insulin therapy with insulin glargine improves in vivo endothelial function in type 2 diabetes.
Arteriosclerosis, thrombosis, and vascular biology 2004;24(2):325-30.
2004: Jukka Westerbacka; Robert Bergholm; Mirja Tiikkainen; Hannele Yki-Järvinen
Glargine and regular human insulin similarly acutely enhance endothelium-dependent vasodilatation in normal subjects.
Arteriosclerosis, thrombosis, and vascular biology 2004;24(2):320-4.
2004: Jukka Westerbacka; Marjo Tamminen; J Cockcroft; Hannele Yki-Järvinen
Comparison of in vivo effects of nitroglycerin and insulin on the aortic pressure waveform.
European journal of clinical investigation 2004;34(1):1-8.
2004: Mirja Tiikkainen; Robert Bergholm; Aila Rissanen; Antti Aro; Irma Salminen; Marjo Tamminen; Kari Teramo; Hannele Yki-Järvinen
Effects of equal weight loss with orlistat and placebo on body fat and serum fatty acid composition and insulin resistance in obese women.
The American journal of clinical nutrition 2004;79(1):22-30.
2003: Jukka Westerbacka; Hannele Yki-Järvinen; Satu Vehkavaara; Anna-Maija Häkkinen; Ruth Andrew; Deborah J Wake; Jonathan R Seckl; Brian R Walker
Body fat distribution and cortisol metabolism in healthy men: enhanced 5beta-reductase and lower cortisol/cortisone metabolite ratios in men with fatty liver.
The Journal of clinical endocrinology and metabolism 2003;88(10):4924-31.
2003: Marjo Tamminen; Jukka Westerbacka; Satu Vehkavaara; Hannele Yki-Järvinen
Insulin therapy improves insulin actions on glucose metabolism and aortic wave reflection in type 2 diabetic patients.
European journal of clinical investigation 2003;33(10):855-60.
2003: Hannele Yki-Järvinen
Insulin resistance and endothelial dysfunction.
Best practice & research. Clinical endocrinology & metabolism 2003;17(3):411-30.
2003: Katja Kannisto; Jussi Sutinen; Elena Korsheninnikova; Rachel M Fisher; Ewa Ehrenborg; Karl Gertow; Antti Virkamäki; Tuulikki Nyman; Hubert Vidal; Anders Hamsten; Hannele Yki-Järvinen
Expression of adipogenic transcription factors, peroxisome proliferator-activated receptor gamma co-activator 1, IL-6 and CD45 in subcutaneous adipose tissue in lipodystrophy associated with highly active antiretroviral therapy.
AIDS (London, England) 2003;17(12):1753-62.
2003: Marjo Tamminen; Riitta Lassila; Jukka Westerbacka; Satu Vehkavaara; Hannele Yki-Järvinen
Obesity is associated with impaired platelet-inhibitory effect of acetylsalicylic acid in nondiabetic subjects.
International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity 2003;27(8):907-11.
2003: Hannele Yki-Järvinen; Robert Bergholm; Marjatta Leirisalo-Repo
Increased inflammatory activity parallels increased basal nitric oxide production and blunted response to nitric oxide in vivo in rheumatoid arthritis.
Annals of the rheumatic diseases 2003;62(7):630-4.
2003: Jussi Sutinen; Anna-Maija Häkkinen; Jukka Westerbacka; Anneli Seppälä-Lindroos; Satu Vehkavaara; Juha Halavaara; Asko Ilari Järvinen; Matti Ristola; Hannele Yki-Järvinen
Rosiglitazone in the treatment of HAART-associated lipodystrophy--a randomized double-blind placebo-controlled study.
Antiviral therapy 2003;8(3):199-207.
2003: Corradina Alagona; Aino Soro; Jukka Westerbacka; Kati Ylitalo; Jukka T Salonen; Riitta Salonen; Hannele Yki-Järvinen; Marja-Riitta Taskinen
Low HDL cholesterol concentration is associated with increased intima-media thickness independent of arterial stiffness in healthy subjects from families with low HDL cholesterol.
European journal of clinical investigation 2003;33(6):457-63.
2003: Robert Bergholm; Mirja Tiikkainen; Satu Vehkavaara; Marjo Tamminen; Kari Teramo; Aila Rissanen; Hannele Yki-Järvinen
Lowering of LDL cholesterol rather than moderate weight loss improves endothelium-dependent vasodilatation in obese women with previous gestational diabetes.
Diabetes care 2003;26(6):1667-72.
2003: Jussi Sutinen; Elena Korsheninnikova; Tohru Funahashi; Yuji Matsuzawa; Tuulikki Nyman; Hannele Yki-Järvinen
Circulating concentration of adiponectin and its expression in subcutaneous adipose tissue in patients with highly active antiretroviral therapy-associated lipodystrophy.
The Journal of clinical endocrinology and metabolism 2003;88(4):1907-10.
2003: Hannele Yki-Järvinen; Jussi Sutinen; Angela Silveira; Elena Korsheninnikova; Rachel M Fisher; Katja Kannisto; Ewa Ehrenborg; Per Eriksson; Anders Hamsten
Regulation of plasma PAI-1 concentrations in HAART-associated lipodystrophy during rosiglitazone therapy.
Arteriosclerosis, thrombosis, and vascular biology 2003;23(4):688-94.
2003: Mirja Tiikkainen; Robert Bergholm; Satu Vehkavaara; Aila Rissanen; Anna-Maija Häkkinen; Marjo Tamminen; Kari Teramo; Hannele Yki-Järvinen
Effects of identical weight loss on body composition and features of insulin resistance in obese women with high and low liver fat content.
Diabetes 2003;52(3):701-7.
2003: Kirsti Hällsten; Hannele Yki-Järvinen; Pauliina Peltoniemi; Vesa Oikonen; Teemu Takala; Jukka Kemppainen; Hanna Laine; Jörgen Bergman; Geremia B Bolli; Juhani Knuuti; Pirjo Nuutila
Insulin- and exercise-stimulated skeletal muscle blood flow and glucose uptake in obese men.
Obesity research 2003;11(2):257-65.
2003: Veera Vihma; Satu Vehkavaara; Hannele Yki-Järvinen; Hannele Hohtari; Matti J Tikkanen
Differential effects of oral and transdermal estradiol treatment on circulating estradiol fatty acid ester concentrations in postmenopausal women.
The Journal of clinical endocrinology and metabolism 2003;88(2):588-93.
2003: Hannele Yki-Järvinen
Nonglycemic effects of insulin.
Clinical cornerstone 2003;Suppl 4():S6-12.
2003: Hannele Yki-Järvinen
Insulin therapy and cardiovascular risk. Introduction.
Clinical cornerstone 2003;Suppl 4():S5.
2002: Hannele Yki-Järvinen
Strategies to prevent hypoglycaemia during insulin therapy in Type 2 diabetes.
Diabetes, nutrition & metabolism 2002;15(6):411-6.
2002: Marjo Tamminen; Jukka Westerbacka; Satu Vehkavaara; Hannele Yki-Järvinen
Insulin-induced decreases in aortic wave reflection and central systolic pressure are impaired in type 2 diabetes.
Diabetes care 2002;25(12):2314-9.
2002: Jussi Sutinen; Anna-Maija Häkkinen; Jukka Westerbacka; Anneli Seppälä-Lindroos; Satu Vehkavaara; Juha Halavaara; Asko Ilari Järvinen; Matti Ristola; Hannele Yki-Järvinen
Increased fat accumulation in the liver in HIV-infected patients with antiretroviral therapy-associated lipodystrophy.
AIDS (London, England) 2002;16(16):2183-93.
2002: Robert Bergholm; Marjatta Leirisalo-Repo; Satu Vehkavaara; Sari Mäkimattila; Marja-Riitta Taskinen; Hannele Yki-Järvinen
Impaired responsiveness to NO in newly diagnosed patients with rheumatoid arthritis.
Arteriosclerosis, thrombosis, and vascular biology 2002;22(10):1637-41.
2002: Hannele Yki-Järvinen
Combination therapy with insulin and oral agents: optimizing glycemic control in patients with type 2 diabetes mellitus.
Diabetes/metabolism research and reviews 2002;18 Suppl 3():S77-81.
2002: Mirja Tiikkainen; Marjo Tamminen; Anna-Maija Häkkinen; Robert Bergholm; Satu Vehkavaara; Juha Halavaara; Kari Teramo; Aila Rissanen; Hannele Yki-Järvinen
Liver-fat accumulation and insulin resistance in obese women with previous gestational diabetes.
Obesity research 2002;10(9):859-67.
2002: Anneli Seppälä-Lindroos; Satu Vehkavaara; Anna-Maija Häkkinen; Takashi Goto; Jukka Westerbacka; Anssi Sovijärvi; Juha Halavaara; Hannele Yki-Järvinen
Fat accumulation in the liver is associated with defects in insulin suppression of glucose production and serum free fatty acids independent of obesity in normal men.
The Journal of clinical endocrinology and metabolism 2002;87(7):3023-8.
2002: Jukka Westerbacka; Hannele Yki-Järvinen
Arterial stiffness and insulin resistance.
Seminars in vascular medicine 2002;2(2):157-64.
2002: Sari Mäkimattila; Kati Ylitalo; A Schlenzka; Marja-Riitta Taskinen; Paula Summanen; Mikko Syvänne; Hannele Yki-Järvinen
Family histories of Type II diabetes and hypertension predict intima-media thickness in patients with Type I diabetes.
Diabetologia 2002;45(5):711-8.
2002: Sari Mäkimattila; Hannele Yki-Järvinen
Endothelial dysfunction in human diabetes.
Current diabetes reports 2002;2(1):26-36.
2002: Hannele Yki-Järvinen
Ectopic fat accumulation: an important cause of insulin resistance in humans.
Journal of the Royal Society of Medicine 2002;95 Suppl 42():39-45.
2002: Jukka Westerbacka; Hannele Yki-Järvinen; Anu M Turpeinen; Aila Rissanen; Satu Vehkavaara; Martti Syrjälä; Riitta Lassila
Inhibition of platelet-collagen interaction: an in vivo action of insulin abolished by insulin resistance in obesity.
Arteriosclerosis, thrombosis, and vascular biology 2002;22(1):167-72.
2001: Pauliina Peltoniemi; Hannele Yki-Järvinen; Hanna Laine; Vesa Oikonen; Tapani Rönnemaa; Kari K Kalliokoski; Olli T Raitakari; Juhani Knuuti; Pirjo Nuutila
Evidence for spatial heterogeneity in insulin- and exercise-induced increases in glucose uptake: studies in normal subjects and patients with type 1 diabetes.
The Journal of clinical endocrinology and metabolism 2001;86(11):5525-33.
2001: Jukka Westerbacka; Anneli Seppälä-Lindroos; Hannele Yki-Järvinen
Resistance to acute insulin induced decreases in large artery stiffness accompanies the insulin resistance syndrome.
The Journal of clinical endocrinology and metabolism 2001;86(11):5262-8.
2001: Antti Virkamäki; Elena Korsheninnikova; Anneli Seppälä-Lindroos; Satu Vehkavaara; Takashi Goto; Juha Halavaara; Anna-Maija Häkkinen; Hannele Yki-Järvinen
Intramyocellular lipid is associated with resistance to in vivo insulin actions on glucose uptake, antilipolysis, and early insulin signaling pathways in human skeletal muscle.
Diabetes 2001;50(10):2337-43.
2001: Sari Mäkimattila; Kalevi Hietaniemi; Tuula Kiviluoto; Tuomo Timonen; Hannele Yki-Järvinen
In vivo glucose-stimulated amylin secretion is increased in nondiabetic patients with pancreatic cancer.
Metabolism: clinical and experimental 2001;50(9):1036-42.
2001: Pauliina Peltoniemi; Hannele Yki-Järvinen; Vesa Oikonen; Airi Oksanen; Teemu Takala; Tapani Rönnemaa; M Erkinjuntti; Juhani Knuuti; Pirjo Nuutila
Resistance to exercise-induced increase in glucose uptake during hyperinsulinemia in insulin-resistant skeletal muscle of patients with type 1 diabetes.
Diabetes 2001;50(6):1371-7.
2001: Satu Vehkavaara; A Silveira; T Hakala-Ala-Pietilä; Antti Virkamäki; Outi Hovatta; Anders Hamsten; Marja-Riitta Taskinen; Hannele Yki-Järvinen
Effects of oral and transdermal estrogen replacement therapy on markers of coagulation, fibrinolysis, inflammation and serum lipids and lipoproteins in postmenopausal women.
Thrombosis and haemostasis 2001;85(4):619-25.
2001: Hannele Yki-Järvinen
Combination therapies with insulin in type 2 diabetes.
Diabetes care 2001;24(4):758-67.
2001: L Ryysy; Hannele Yki-Järvinen
Improvement of glycemic control by 1 year of insulin therapy leads to a sustained decrease in sE-selectin concentrations in type 2 diabetes.
Diabetes care 2001;24(3):549-54.
2001: Robert Bergholm; Jukka Westerbacka; Satu Vehkavaara; Anneli Seppälä-Lindroos; Takashi Goto; Hannele Yki-Järvinen
Insulin sensitivity regulates autonomic control of heart rate variation independent of body weight in normal subjects.
The Journal of clinical endocrinology and metabolism 2001;86(3):1403-9.
2001: J R Cockcroft; I B Wilkinson; Hannele Yki-Järvinen
Multiple risk factor intervention in type 2 diabetes: an opportunity not to be missed.
Diabetes, obesity & metabolism 2001;3(1):1-8.
2000: Satu Vehkavaara; Jukka Westerbacka; T Hakala-Ala-Pietilä; Antti Virkamäki; Outi Hovatta; Hannele Yki-Järvinen
Effect of estrogen replacement therapy on insulin sensitivity of glucose metabolism and preresistance and resistance vessel function in healthy postmenopausal women.
The Journal of clinical endocrinology and metabolism 2000;85(12):4663-70.
2000: Satu Vehkavaara; T Hakala-Ala-Pietilä; Antti Virkamäki; Robert Bergholm; Christian Ehnholm; Outi Hovatta; Marja-Riitta Taskinen; Hannele Yki-Järvinen
Differential effects of oral and transdermal estrogen replacement therapy on endothelial function in postmenopausal women.
Circulation 2000;102(22):2687-93.
2000: Hannele Yki-Järvinen
Management of type 2 diabetes mellitus and cardiovascular risk: lessons from intervention trials.
Drugs 2000;60(5):975-83.
2000: Sari Mäkimattila; A Schlenzka; M Mäntysaari; Robert Bergholm; Paula Summanen; P Saar; H Erkkilä; Hannele Yki-Järvinen
Predictors of abnormal cardiovascular autonomic function measured by frequence domain analysis of heart rate variability and conventional tests in patients with type 1 diabetes.
Diabetes care 2000;23(11):1686-93.
2000: Michael Stumvoll; Asimina Mitrakou; Walkyria P Pimenta; T Jenssen; Hannele Yki-Järvinen; Timon W van Haeften; H Häring; A Fritsche; John E Gerich
Assessment of insulin secretion from the oral glucose tolerance test in white patients with type 2 diabetes.
Diabetes care 2000;23(9):1440-1.
2000: Juha Vakkilainen; Sari Mäkimattila; Anneli Seppälä-Lindroos; Satu Vehkavaara; Sanni Lahdenperä; Per-Henrik Groop; Marja-Riitta Taskinen; Hannele Yki-Järvinen
Endothelial dysfunction in men with small LDL particles.
Circulation 2000;102(7):716-21.
2000: Sari Mäkimattila; M S Fineman; Hannele Yki-Järvinen
Deficiency of total and nonglycosylated amylin in plasma characterizes subjects with impaired glucose tolerance and type 2 diabetes.
The Journal of clinical endocrinology and metabolism 2000;85(8):2822-7.
2000: Hannele Yki-Järvinen; A Dressler; M Ziemen
Less nocturnal hypoglycemia and better post-dinner glucose control with bedtime insulin glargine compared with bedtime NPH insulin during insulin combination therapy in type 2 diabetes. HOE 901/3002 Study Group.
Diabetes care 2000;23(8):1130-6.
2000: Hannele Yki-Järvinen
A simple therapeutic combination for type 2 diabetes.
Hospital practice (1995) 2000;35(7):63-6, 72-4.
2000: Pirjo Nuutila; Pauliina Peltoniemi; Vesa Oikonen; K Larmola; Jukka Kemppainen; Teemu Takala; Hannu Sipilä; Airi Oksanen; Ulla Ruotsalainen; Geremia B Bolli; Hannele Yki-Järvinen
Enhanced stimulation of glucose uptake by insulin increases exercise-stimulated glucose uptake in skeletal muscle in humans: studies using [15O]O2, [15O]H2O, [18F]fluoro-deoxy-glucose, and positron emission tomography.
Diabetes 2000;49(7):1084-91.
2000: Tapio Utriainen; S Lovisatti; Sari Mäkimattila; A Bertoldo; S Weintraub; Ralph DeFronzo; Claudio Cobelli; Hannele Yki-Järvinen
Direct measurement of the lumped constant for 2-deoxy-[1-(14)C]glucose in vivo in human skeletal muscle.
American journal of physiology. Endocrinology and metabolism 2000;279(1):E228-33.
2000: Hannele Yki-Järvinen; Jukka Westerbacka
Vascular actions of insulin in obesity.
International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity 2000;24 Suppl 2():S25-8.
2000: C Vogt; Hossein Ardehali; Patricia Iozzo; Hannele Yki-Järvinen; JA Koval; K Maezono; Merri L Pendergrass; Richard L Printz; Daryl K Granner; Ralph DeFronzo; Lawrence J. Manderino
Regulation of hexokinase II expression in human skeletal muscle in vivo.
Metabolism: clinical and experimental 2000;49(6):814-8.
2000: L Ryysy; Anna-Maija Häkkinen; Takashi Goto; Satu Vehkavaara; Jukka Westerbacka; Juha Halavaara; Hannele Yki-Järvinen
Hepatic fat content and insulin action on free fatty acids and glucose metabolism rather than insulin absorption are associated with insulin requirements during insulin therapy in type 2 diabetic patients.
Diabetes 2000;49(5):749-58.
2000: Jukka Westerbacka; A Uosukainen; Sari Mäkimattila; A Schlenzka; Hannele Yki-Järvinen
Insulin-induced decrease in large artery stiffness is impaired in uncomplicated type 1 diabetes mellitus.
Hypertension 2000;35(5):1043-8.
2000: Michael Stumvoll; Asimina Mitrakou; Walkyria P Pimenta; T Jenssen; Hannele Yki-Järvinen; Timon W van Haeften; Walter Renn; John E Gerich
Use of the oral glucose tolerance test to assess insulin release and insulin sensitivity.
Diabetes care 2000;23(3):295-301.
2000: Satu Vehkavaara; Sari Mäkimattila; A Schlenzka; Juha Vakkilainen; Jukka Westerbacka; Hannele Yki-Järvinen
Insulin therapy improves endothelial function in type 2 diabetes.
Arteriosclerosis, thrombosis, and vascular biology 2000;20(2):545-50.
1999: Hanna Laine; C Katoh; Matti Luotolahti; Hannele Yki-Järvinen; Ilkka Kantola; Antti Jula; Teemu Takala; Ulla Ruotsalainen; H Iida; Merja Haaparanta; Pirjo Nuutila; Juhani Knuuti
Myocardial oxygen consumption is unchanged but efficiency is reduced in patients with essential hypertension and left ventricular hypertrophy.
Circulation 1999;100(24):2425-30.
1999: Satu Vehkavaara; Anneli Seppälä-Lindroos; Jukka Westerbacka; Per-Henrik Groop; Hannele Yki-Järvinen
In vivo endothelial dysfunction characterizes patients with impaired fasting glucose.
Diabetes care 1999;22(12):2055-60.
1999: Sari Mäkimattila; J S Luoma; Seppo Ylä-Herttuala; Robert Bergholm; Tapio Utriainen; Antti Virkamäki; M Mäntysaari; Paula Summanen; Hannele Yki-Järvinen
Autoantibodies against oxidized LDL and endothelium-dependent vasodilation in insulin-dependent diabetes mellitus.
Atherosclerosis 1999;147(1):115-22.
1999: Niina Mero; L Suurinkeroinen; Mikko Syvänne; P Knudsen; Hannele Yki-Järvinen; Marja-Riitta Taskinen
Delayed clearance of postprandial large TG-rich particles in normolipidemic carriers of LPL Asn291Ser gene variant.
Journal of lipid research 1999;40(9):1663-70.
1999: Robert Bergholm; Sari Mäkimattila; Miia Valkonen; Ming-Lin Liu; Sanni Lahdenperä; Marja-Riitta Taskinen; Anssi Sovijärvi; P Malmberg; Hannele Yki-Järvinen
Intense physical training decreases circulating antioxidants and endothelium-dependent vasodilatation in vivo.
Atherosclerosis 1999;145(2):341-9.
1999: Mary-Elizabeth Patti; A Virkamäki; Edwin J Landaker; C Ronald Kahn; Hannele Yki-Järvinen
Activation of the hexosamine pathway by glucosamine in vivo induces insulin resistance of early postreceptor insulin signaling events in skeletal muscle.
Diabetes 1999;48(8):1562-71.
1999: Hannele Yki-Järvinen
Diabetes mellitus and heart disease.
IDrugs : the investigational drugs journal 1999;2(6):576-8.
1999: Sari Mäkimattila; Ming-Lin Liu; Juha Vakkilainen; A Schlenzka; Sanni Lahdenperä; Mikko Syvänne; M Mäntysaari; Paula Summanen; Robert Bergholm; Marja-Riitta Taskinen; Hannele Yki-Järvinen
Impaired endothelium-dependent vasodilation in type 2 diabetes. Relation to LDL size, oxidized LDL, and antioxidants.
Diabetes care 1999;22(6):973-81.
1999: Ming-Lin Liu; Robert Bergholm; Sari Mäkimattila; Sanni Lahdenperä; Miia Valkonen; H Hilden; Hannele Yki-Järvinen; Marja-Riitta Taskinen
A marathon run increases the susceptibility of LDL to oxidation in vitro and modifies plasma antioxidants.
The American journal of physiology 1999;276(6 Pt 1):E1083-91.
1999: Jukka Westerbacka; I Wilkinson; J Cockcroft; T Utriainen; Satu Vehkavaara; Hannele Yki-Järvinen
Diminished wave reflection in the aorta. A novel physiological action of insulin on large blood vessels.
Hypertension 1999;33(5):1118-22.
1999: A Virkamäki; Hannele Yki-Järvinen
Allosteric regulation of glycogen synthase and hexokinase by glucosamine-6-phosphate during glucosamine-induced insulin resistance in skeletal muscle and heart.
Diabetes 1999;48(5):1101-7.
1999: Sari Mäkimattila; K Nikkilä; Hannele Yki-Järvinen
Causes of weight gain during insulin therapy with and without metformin in patients with Type II diabetes mellitus.
Diabetologia 1999;42(4):406-12.
1999: Teemu Takala; Pirjo Nuutila; Juhani Knuuti; Matti Luotolahti; Hannele Yki-Järvinen
Insulin action on heart and skeletal muscle glucose uptake in weight lifters and endurance athletes.
The American journal of physiology 1999;276(4 Pt 1):E706-11.
1999: Jukka Westerbacka; Satu Vehkavaara; Robert Bergholm; I Wilkinson; J Cockcroft; Hannele Yki-Järvinen
Marked resistance of the ability of insulin to decrease arterial stiffness characterizes human obesity.
Diabetes 1999;48(4):821-7.
1999: Hannele Yki-Järvinen; L Ryysy; K Nikkilä; Timo Tulokas; R Vanamo; Matti Heikkilä
Comparison of bedtime insulin regimens in patients with type 2 diabetes mellitus. A randomized, controlled trial.
Annals of internal medicine 1999;130(5):389-96.
1999: P Iozzo; H Beck-Nielsen; M Laakso; U Smith; Hannele Yki-Järvinen; Ele Ferrannini
Independent influence of age on basal insulin secretion in nondiabetic humans. European Group for the Study of Insulin Resistance.
The Journal of clinical endocrinology and metabolism 1999;84(3):863-8.
1999: Hannele Yki-Järvinen
[Treatment of hyperglycemia in adult-onset diabetes mellitus].
Duodecim; lääketieteellinen aikakauskirja 1999;115(10):1155-64.
1999: Hannele Yki-Järvinen
[What should be the target of therapy in the adult-onset diabetes mellitus?].
Duodecim; lääketieteellinen aikakauskirja 1999;115(10):1119-20.
1999: Hannele Yki-Järvinen; K Nikkilä; Sari Mäkimattila
Metformin prevents weight gain by reducing dietary intake during insulin therapy in patients with type 2 diabetes mellitus.
Drugs 1999;58 Suppl 1():53-4; discussion 75-82.
1999: Hannele Yki-Järvinen; Tuulikki Nyman; E Rissanen; Marketta Leino; Sammy Hämäläinen; Antti Virkamäki; S Hauguel-de Mouzon
Glutamine: fructose-6-phosphate amidotransferase activity and gene expression are regulated in a tissue-specific fashion in pregnant rats.
Life sciences 1999;65(2):215-23.
1998: Hannele Yki-Järvinen
Toxicity of hyperglycaemia in type 2 diabetes.
Diabetes/metabolism reviews 1998;14 Suppl 1():S45-50.
1998: Sari Mäkimattila; Paula Summanen; IH Matinlauri; M Mäntysaari; A Schlenzka; M Aalto; Kerttu Irjala; Hannele Yki-Järvinen
Serum total renin, an independent marker of the activity and severity of retinopathy in patients with IDDM.
The British journal of ophthalmology 1998;82(8):939-44.
1998: Hanna Laine; Juhani Knuuti; Ulla Ruotsalainen; Tapio Utriainen; Vesa Oikonen; Maria Raitakari; Matti Luotolahti; Olli A Kirvelä; Paolo Vicini; C Cobelli; Pirjo Nuutila; Hannele Yki-Järvinen
Preserved relative dispersion but blunted stimulation of mean flow, absolute dispersion, and blood volume by insulin in skeletal muscle of patients with essential hypertension.
Circulation 1998;97(21):2146-53.
1998: Tapio Utriainen; Teemu Takala; Matti Luotolahti; Tapani Rönnemaa; Hanna Laine; Ulla Ruotsalainen; Merja Haaparanta; Pirjo Nuutila; Hannele Yki-Järvinen
Insulin resistance characterizes glucose uptake in skeletal muscle but not in the heart in NIDDM.
Diabetologia 1998;41(5):555-9.
1998: R Malmström; CJ Packard; Muriel J Caslake; Dorothy Bedford; P Stewart; Hannele Yki-Järvinen; J Shepherd; Marja-Riitta Taskinen
Effects of insulin and acipimox on VLDL1 and VLDL2 apolipoprotein B production in normal subjects.
Diabetes 1998;47(5):779-87.
1998: Hannele Yki-Järvinen; Tapio Utriainen
Insulin-induced vasodilatation: physiology or pharmacology?
Diabetologia 1998;41(4):369-79.
1998: Hannele Yki-Järvinen; Antti Virkamäki; MC Daniels; Donald A McClain; W K Gottschalk
Insulin and glucosamine infusions increase O-linked N-acetyl-glucosamine in skeletal muscle proteins in vivo.
Metabolism: clinical and experimental 1998;47(4):449-55.
1998: Hanna Laine; Juhani Knuuti; Ulla Ruotsalainen; Maria Raitakari; H Iida; Jukka Kapanen; Olli A Kirvelä; Merja Haaparanta; Hannele Yki-Järvinen; Pirjo Nuutila
Insulin resistance in essential hypertension is characterized by impaired insulin stimulation of blood flow in skeletal muscle.
Journal of hypertension 1998;16(2):211-9.
1998: Sari Mäkimattila; M Mäntysaari; A Schlenzka; Paula Summanen; Hannele Yki-Järvinen
Mechanisms of altered hemodynamic and metabolic responses to insulin in patients with insulin-dependent diabetes mellitus and autonomic dysfunction.
The Journal of clinical endocrinology and metabolism 1998;83(2):468-75.
1998: Jyri Lommi; Markku Kupari; Hannele Yki-Järvinen
Free fatty acid kinetics and oxidation in congestive heart failure.
The American journal of cardiology 1998;81(1):45-50.
1997: Hannele Yki-Järvinen; L Ryysy; M Kauppila; Erkki Kujansuu; Jari Lahti; T Marjanen; Leo Niskanen; S Rajala; Sirpa Salo; P Seppälä; Timo Tulokas; J Viikari; Marja-Riitta Taskinen
Effect of obesity on the response to insulin therapy in noninsulin-dependent diabetes mellitus.
The Journal of clinical endocrinology and metabolism 1997;82(12):4037-43.
1997: Maria Raitakari; Pirjo Nuutila; Juhani Knuuti; Olli T Raitakari; Hanna Laine; Ulla Ruotsalainen; Olli A Kirvelä; Teemu Takala; H Iida; Hannele Yki-Järvinen
Effects of insulin on blood flow and volume in skeletal muscle of patients with IDDM: studies using [15O]H2O, [15O]CO, and positron emission tomography.
Diabetes 1997;46(12):2017-21.
1997: Ele Ferrannini; Andrea Natali; Brunella Capaldo; Mikko Lehtovirta; S Jacob; Hannele Yki-Järvinen
Insulin resistance, hyperinsulinemia, and blood pressure: role of age and obesity. European Group for the Study of Insulin Resistance (EGIR).
Hypertension 1997;30(5):1144-9.
1997: Paolo Vicini; R C Bonadonna; Tapio Utriainen; Pirjo Nuutila; Maria Raitakari; Hannele Yki-Järvinen; Claudio Cobelli
Estimation of blood flow heterogeneity distribution in human skeletal muscle from positron emission tomography data.
Annals of biomedical engineering 1997;25(5):906-10.
1997: Tapio Utriainen; Pirjo Nuutila; Teemu Takala; Paolo Vicini; Ulla Ruotsalainen; Tapani Rönnemaa; Tuula Tolvanen; Maria Raitakari; Merja Haaparanta; Olli A Kirvelä; C Cobelli; Hannele Yki-Järvinen
Intact insulin stimulation of skeletal muscle blood flow, its heterogeneity and redistribution, but not of glucose uptake in non-insulin-dependent diabetes mellitus.
The Journal of clinical investigation 1997;100(4):777-85.
1997: Hannele Yki-Järvinen
Acute and chronic effects of hyperglycaemia on glucose metabolism: implications for the development of new therapies.
Diabetic medicine : a journal of the British Diabetic Association 1997;14 Suppl 3():S32-7.
1997: R Malmström; CJ Packard; T D Watson; Sakari Rannikko; Muriel J Caslake; Dorothy Bedford; P Stewart; Hannele Yki-Järvinen; J Shepherd; Marja-Riitta Taskinen
Metabolic basis of hypotriglyceridemic effects of insulin in normal men.
Arteriosclerosis, thrombosis, and vascular biology 1997;17(7):1454-64.
1997: Hannele Yki-Järvinen; Sari Mäkimattila
Insulin resistance due to hyperglycaemia: an adaptation protecting insulin-sensitive tissues.
Diabetologia 1997;40 Suppl 2():S141-4.
1997: Antti Virkamäki; E Rissanen; Sammy Hämäläinen; Tapio Utriainen; Hannele Yki-Järvinen
Incorporation of [3-3H]glucose and 2-[1-14C]deoxyglucose into glycogen in heart and skeletal muscle in vivo: implications for the quantitation of tissue glucose uptake.
Diabetes 1997;46(7):1106-10.
1997: Antti Virkamäki; MC Daniels; Sammy Hämäläinen; Tapio Utriainen; Donald A McClain; Hannele Yki-Järvinen
Activation of the hexosamine pathway by glucosamine in vivo induces insulin resistance in multiple insulin sensitive tissues.
Endocrinology 1997;138(6):2501-7.
1997: R Malmström; CJ Packard; Muriel J Caslake; Dorothy Bedford; P Stewart; Hannele Yki-Järvinen; J Shepherd; Marja-Riitta Taskinen
Defective regulation of triglyceride metabolism by insulin in the liver in NIDDM.
Diabetologia 1997;40(4):454-62.
1997: Hannele Yki-Järvinen
MODY genes and mutations in hepatocyte nuclear factors.
Lancet 1997;349(9051):516-7.
1997: Sari Mäkimattila; M Mäntysaari; Per-Henrik Groop; Paula Summanen; Antti Virkamäki; A Schlenzka; Johan Fagerudd; Hannele Yki-Järvinen
Hyperreactivity to nitrovasodilators in forearm vasculature is related to autonomic dysfunction in insulin-dependent diabetes mellitus.
Circulation 1997;95(3):618-25.
1997: J Westerbacka; Hannele Yki-Järvinen
[Troglitazone, an insulin action enhancer--a drug of precision to treat adult-onset diabetes].
Duodecim; lääketieteellinen aikakauskirja 1997;113(19):1847-8.
1997: Hannele Yki-Järvinen; C Vogt; Patricia Iozzo; R Pipek; MC Daniels; Antti Virkamäki; Sari Mäkimattila; Lawrence J. Manderino; Ralph DeFronzo; Donald A McClain; W K Gottschalk
UDP-N-acetylglucosamine transferase and glutamine: fructose 6-phosphate amidotransferase activities in insulin-sensitive tissues.
Diabetologia 1997;40(1):76-81.
1996: Tapio Utriainen; Sari Mäkimattila; Antti Virkamäki; Robert Bergholm; Hannele Yki-Järvinen
Dissociation between insulin sensitivity of glucose uptake and endothelial function in normal subjects.
Diabetologia 1996;39(12):1477-82.
1996: Tapio Utriainen; Sari Mäkimattila; Antti Virkamäki; H Lindholm; Anssi Sovijärvi; Hannele Yki-Järvinen
Physical fitness and endothelial function (nitric oxide synthesis) are independent determinants of insulin-stimulated blood flow in normal subjects.
The Journal of clinical endocrinology and metabolism 1996;81(12):4258-63.
1996: Maria Raitakari; Pirjo Nuutila; Ulla Ruotsalainen; Hanna Laine; Mika Teräs; H Iida; Sari Mäkimattila; Tapio Utriainen; Vesa Oikonen; Hannu Sipilä; Merja Haaparanta; Olof Solin; U Wegelius; Juhani Knuuti; Hannele Yki-Järvinen
Evidence for dissociation of insulin stimulation of blood flow and glucose uptake in human skeletal muscle: studies using [15O]H2O, [18F]fluoro-2-deoxy-D-glucose, and positron emission tomography.
Diabetes 1996;45(11):1471-7.
1996: Maria Raitakari; Pirjo Nuutila; Ulla Ruotsalainen; Mika Teräs; E Eronen; Hanna Laine; Olli T Raitakari; H Iida; Juhani Knuuti; Hannele Yki-Järvinen
Relationship between limb and muscle blood flow in man.
The Journal of physiology 1996;496 ( Pt 2)():543-9.
1996: Tapio Utriainen; R Malmström; Sari Mäkimattila; Hannele Yki-Järvinen
Supraphysiological hyperinsulinemia increases plasma leptin concentrations after 4 h in normal subjects.
Diabetes 1996;45(10):1364-6.
1996: Sari Mäkimattila; Antti Virkamäki; Per-Henrik Groop; J Cockcroft; Tapio Utriainen; Johan Fagerudd; Hannele Yki-Järvinen
Chronic hyperglycemia impairs endothelial function and insulin sensitivity via different mechanisms in insulin-dependent diabetes mellitus.
Circulation 1996;94(6):1276-82.
1996: W Pimenta; Asimina Mitrakou; T Jensen; Hannele Yki-Järvinen; G Daily; John E Gerich
Insulin secretion and insulin sensitivity in people with impaired glucose tolerance.
Diabetic medicine : a journal of the British Diabetic Association 1996;13(9 Suppl 6):S33-6.
1996: R Malmström; Marja-Riitta Taskinen; Sirkka-Liisa Karonen; Hannele Yki-Järvinen
Insulin increases plasma leptin concentrations in normal subjects and patients with NIDDM.
Diabetologia 1996;39(8):993-6.
1996: Tapio Utriainen; A Holmäng; P Björntorp; Sari Mäkimattila; Anssi Sovijärvi; H Lindholm; Hannele Yki-Järvinen
Physical fitness, muscle morphology, and insulin-stimulated limb blood flow in normal subjects.
The American journal of physiology 1996;270(5 Pt 1):E905-11.
1996: Pirjo Nuutila; Maria Raitakari; Hanna Laine; Olli A Kirvelä; Teemu Takala; Tapio Utriainen; Sari Mäkimattila; Otto Pitkänen; Ulla Ruotsalainen; H Iida; Juhani Knuuti; Hannele Yki-Järvinen
Role of blood flow in regulating insulin-stimulated glucose uptake in humans. Studies using bradykinin, [15O]water, and [18F]fluoro-deoxy-glucose and positron emission tomography.
The Journal of clinical investigation 1996;97(7):1741-7.
1996: Hannele Yki-Järvinen
[Glucose toxicity--pros and cons. Useful adaptation and common cause of insulin resistance in diabetic patients].
Nordisk medicin 1996;111(3):80-3.
1996: Hannele Yki-Järvinen; MC Daniels; Antti Virkamäki; Sari Mäkimattila; Ralph DeFronzo; Donald A McClain
Increased glutamine:fructose-6-phosphate amidotransferase activity in skeletal muscle of patients with NIDDM.
Diabetes 1996;45(3):302-7.
1996: L Mäkelä; P Nikkanen; P Salmi; Hannele Yki-Järvinen
[Insulin dependent diabetes mellitus patients benefit from teaching programs].
Duodecim; lääketieteellinen aikakauskirja 1996;112(24):2389-94.
1996: Hannele Yki-Järvinen
[Insulin treatment in NIDDM].
Duodecim; lääketieteellinen aikakauskirja 1996;112(13):1195-202.
1995: Hannele Yki-Järvinen
Role of insulin resistance in the pathogenesis of NIDDM.
Diabetologia 1995;38(12):1378-88.
1995: Hannele Yki-Järvinen; Sari Mäkimattila; Tapio Utriainen; E M Rutanen
Portal insulin concentrations rather than insulin sensitivity regulate serum sex hormone-binding globulin and insulin-like growth factor binding protein 1 in vivo.
The Journal of clinical endocrinology and metabolism 1995;80(11):3227-32.
1995: M Löfman; Hannele Yki-Järvinen; M Parkkonen; J Lindström; L Koranyi; C Schalin-Jäntti; Leif Groop
Increased concentrations of glycogen synthase protein in skeletal muscle of patients with NIDDM.
The American journal of physiology 1995;269(1 Pt 1):E27-32.
1995: Juhani Knuuti; Maija Mäki; Hannele Yki-Järvinen; Liisa-Maria Voipio-Pulkki; R Härkönen; Merja Haaparanta; Pirjo Nuutila
The effect of insulin and FFA on myocardial glucose uptake.
Journal of molecular and cellular cardiology 1995;27(7):1359-67.
1995: Timo Sane; Petteri Knudsen; H Vuorinen-Markkola; Hannele Yki-Järvinen; Marja-Riitta Taskinen
Decreasing triglyceride by gemfibrozil therapy does not affect the glucoregulatory or antilipolytic effect of insulin in nondiabetic subjects with mild hypertriglyceridemia.
Metabolism: clinical and experimental 1995;44(5):589-96.
1995: Tapio Utriainen; R Malmström; Sari Mäkimattila; Hannele Yki-Järvinen
Methodological aspects, dose-response characteristics and causes of interindividual variation in insulin stimulation of limb blood flow in normal subjects.
Diabetologia 1995;38(5):555-64.
1995: Antti Virkamäki; Hannele Yki-Järvinen
Role of prostaglandins in mediating alterations in glucose metabolism during acute endotoxemia in the rat.
Endocrinology 1995;136(4):1701-6.
1995: Tuomo Kuusi; Hannele Yki-Järvinen; R Kauppinen-Mäkelin; Matti Jauhiainen; Christian Ehnholm; M Kauppila; P Seppälä; J Viikari; Erkki Kujansuu; S Rajala
Effect of insulin treatment on serum lipoprotein(a) in non-insulin-dependent diabetes.
European journal of clinical investigation 1995;25(3):194-200.
1995: H Vuorinen-Markkola; Hannele Yki-Järvinen
Antihypertensive therapy with enalapril improves glucose storage and insulin sensitivity in hypertensive patients with non-insulin-dependent diabetes mellitus.
Metabolism: clinical and experimental 1995;44(1):85-9.
1995: I Puhakainen; I Ahola; Hannele Yki-Järvinen
Dietary supplementation with n-3 fatty acids increases gluconeogenesis from glycerol but not hepatic glucose production in patients with non-insulin-dependent diabetes mellitus.
The American journal of clinical nutrition 1995;61(1):121-6.
1995: Pirjo Nuutila; Juhani Knuuti; Maija Mäki; Hanna Laine; Ulla Ruotsalainen; Mika Teräs; Merja Haaparanta; Olof Solin; Hannele Yki-Järvinen
Gender and insulin sensitivity in the heart and in skeletal muscles. Studies using positron emission tomography.
Diabetes 1995;44(1):31-6.
1994: Pirjo Nuutila; Juhani Knuuti; Maria Raitakari; Ulla Ruotsalainen; Mika Teräs; Liisa-Maria Voipio-Pulkki; Merja Haaparanta; Olof Solin; U Wegelius; Hannele Yki-Järvinen
Effect of antilipolysis on heart and skeletal muscle glucose uptake in overnight fasted humans.
The American journal of physiology 1994;267(6 Pt 1):E941-6.
1994: I Puhakainen; Marja-Riitta Taskinen; Hannele Yki-Järvinen
Comparison of acute daytime and nocturnal insulinization on diurnal glucose homeostasis in NIDDM.
Diabetes care 1994;17(8):805-9.
1994: Kaj Metsärinne; Outi Saijonmaa; Hannele Yki-Järvinen; Frej Fyhrquist
Insulin increases the release of endothelin in endothelial cell cultures in vitro but not in vivo.
Metabolism: clinical and experimental 1994;43(7):878-82.
1994: Juhani Knuuti; Hannele Yki-Järvinen; Liisa-Maria Voipio-Pulkki; Maija Mäki; Ulla Ruotsalainen; R Härkönen; Mika Teräs; Merja Haaparanta; Jörgen Bergman; Jaakko Hartiala
Enhancement of myocardial [fluorine-18]fluorodeoxyglucose uptake by a nicotinic acid derivative.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 1994;35(6):989-98.
1994: Pirjo Nuutila; Juhani Knuuti; Olli Heinonen; Ulla Ruotsalainen; Mika Teräs; Jörgen Bergman; Olof Solin; Hannele Yki-Järvinen; Liisa-Maria Voipio-Pulkki; U Wegelius
Different alterations in the insulin-stimulated glucose uptake in the athlete's heart and skeletal muscle.
The Journal of clinical investigation 1994;93(5):2267-74.
1994: Antti Virkamäki; Hannele Yki-Järvinen
Mechanisms of insulin resistance during acute endotoxemia.
Endocrinology 1994;134(5):2072-8.
1994: C Schalin-Jäntti; Hannele Yki-Järvinen; L Koranyi; R Bourey; J Lindström; P Nikula-Ijäs; A Franssila-Kallunki; Leif C Groop
Effect of insulin on GLUT-4 mRNA and protein concentrations in skeletal muscle of patients with NIDDM and their first-degree relatives.
Diabetologia 1994;37(4):401-7.
1994: Hannele Yki-Järvinen
Pathogenesis of non-insulin-dependent diabetes mellitus.
Lancet 1994;343(8889):91-5.
1994: H Vuorinen-Markkola; Hannele Yki-Järvinen
Hyperuricemia and insulin resistance.
The Journal of clinical endocrinology and metabolism 1994;78(1):25-9.
1993: I Puhakainen; Hannele Yki-Järvinen
Inhibition of lipolysis decreases lipid oxidation and gluconeogenesis from lactate but not fasting hyperglycemia or total hepatic glucose production in NIDDM.
Diabetes 1993;42(12):1694-9.
1993: Eeva-Marja Rutanen; T Kärkkäinen; Ulf-Hakan Stenman; Hannele Yki-Järvinen
Aging is associated with decreased suppression of insulin-like growth factor binding protein-1 by insulin.
The Journal of clinical endocrinology and metabolism 1993;77(5):1152-5.
1993: Hannele Yki-Järvinen
Action of insulin on glucose metabolism in vivo.
Baillière's clinical endocrinology and metabolism 1993;7(4):903-27.
1993: H Vuorinen-Markkola; Hannele Yki-Järvinen; Marja-Riitta Taskinen
Lowering of triglycerides by gemfibrozil affects neither the glucoregulatory nor antilipolytic effect of insulin in type 2 (non-insulin-dependent) diabetic patients.
Diabetologia 1993;36(2):161-9.
1993: Veikko Koivisto; Hannele Yki-Järvinen
Fructose and insulin sensitivity in patients with type 2 diabetes.
Journal of internal medicine 1993;233(2):145-53.
1992: Hannele Yki-Järvinen; M Kauppila; Erkki Kujansuu; J Lahti; T Marjanen; L Niskanen; S Rajala; L Ryysy; S Salo; P Seppälä
Comparison of insulin regimens in patients with non-insulin-dependent diabetes mellitus.
The New England journal of medicine 1992;327(20):1426-33.
1992: M Kubota; A Virkamäki; Hannele Yki-Järvinen
Ethanol stimulates glycogenolysis in livers from fed rats.
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.) 1992;201(1):114-8.
1992: Hannele Yki-Järvinen; H Vuorinen-Markkola; L Koranyi; R Bourey; K Tordjman; Mike Mueckler; A M Permutt; Veikko Koivisto
Defect in insulin action on expression of the muscle/adipose tissue glucose transporter gene in skeletal muscle of type 1 diabetic patients.
The Journal of clinical endocrinology and metabolism 1992;75(3):795-9.
1992: I Puhakainen; Veikko Koivisto; Hannele Yki-Järvinen
Lipolysis and gluconeogenesis from glycerol are increased in patients with noninsulin-dependent diabetes mellitus.
The Journal of clinical endocrinology and metabolism 1992;75(3):789-94.
1992: Hannele Yki-Järvinen
Glucose toxicity.
Endocrine reviews 1992;13(3):415-31.
1992: A Virkamäki; I Puhakainen; Veikko Koivisto; H Vuorinen-Markkola; Hannele Yki-Järvinen
Mechanisms of hepatic and peripheral insulin resistance during acute infections in humans.
The Journal of clinical endocrinology and metabolism 1992;74(3):673-9.
1992: Timo Sane; E Helve; Hannele Yki-Järvinen; Marja-Riitta Taskinen
One-year response to evening insulin therapy in non-insulin-dependent diabetes.
Journal of internal medicine 1992;231(3):253-60.
1992: H Vuorinen-Markkola; I Puhakainen; Hannele Yki-Järvinen
No evidence for short-term regulation of plasminogen activator inhibitor activity by insulin in man.
Thrombosis and haemostasis 1992;67(1):117-20.
1991: L I Koranyi; R E Bourey; H Vuorinen-Markkola; Veikko Koivisto; Mike Mueckler; M Alan Permutt; Hannele Yki-Järvinen
Level of skeletal muscle glucose transporter protein correlates with insulin-stimulated whole body glucose disposal in man.
Diabetologia 1991;34(10):763-5.
1991: I Puhakainen; Veikko Koivisto; Hannele Yki-Järvinen
No reduction in total hepatic glucose output by inhibition of gluconeogenesis with ethanol in NIDDM patients.
Diabetes 1991;40(10):1319-27.
1991: Hannele Yki-Järvinen; I Puhakainen; Veikko Koivisto
Effect of free fatty acids on glucose uptake and nonoxidative glycolysis across human forearm tissues in the basal state and during insulin stimulation.
The Journal of clinical endocrinology and metabolism 1991;72(6):1268-77.
1991: Hannele Yki-Järvinen; I Puhakainen; C Saloranta; Leif Groop; Marja-Riitta Taskinen
Demonstration of a novel feedback mechanism between FFA oxidation from intracellular and intravascular sources.
The American journal of physiology 1991;260(5 Pt 1):E680-9.
1990: Hannele Yki-Järvinen
Acute and chronic effects of hyperglycaemia on glucose metabolism.
Diabetologia 1990;33(10):579-85.
1990: A Virkamäki; I Puhakainen; N Nurjhan; J E Gerich; Hannele Yki-Järvinen
Measurement of lactate formation from glucose using [6-3H]- and [6-14C]glucose in humans.
The American journal of physiology 1990;259(3 Pt 1):E397-404.
1990: Hannele Yki-Järvinen; Clifton Bogardus; J E Foley
Regulation of plasma lactate concentration in resting human subjects.
Metabolism: clinical and experimental 1990;39(8):859-64.
1990: V A Koivisto; Hannele Yki-Järvinen
Changes in muscle glucose metabolism in type 1 diabetes.
Annals of medicine 1990;22(3):201-5.
1990: Hannele Yki-Järvinen
Evidence for a primary role of insulin resistance in the pathogenesis of type 2 diabetes.
Annals of medicine 1990;22(3):197-200.
1990: Veikko Koivisto; Hannele Yki-Järvinen; I Puhakainen; A Virkamäki; J Kolaczynski; Ralph DeFronzo
No evidence for isotope discrimination of tritiated glucose tracers in measurements of glucose turnover rates in man.
Diabetologia 1990;33(3):168-73.
1990: Hannele Yki-Järvinen; K Sahlin; J M Ren; Veikko Koivisto
Localization of rate-limiting defect for glucose disposal in skeletal muscle of insulin-resistant type I diabetic patients.
Diabetes 1990;39(2):157-67.
1990: Hannele Yki-Järvinen; V Koivisto
[Why is there an impaired insulin action in a patient with diabetes?].
Duodecim; lääketieteellinen aikakauskirja 1990;106(9):684-93.
1990: Hannele Yki-Järvinen
[How does adult-type diabetes develop?].
Duodecim; lääketieteellinen aikakauskirja 1990;106(9):646-50.
1989: Hannele Yki-Järvinen; K Sammalkorpi; Veikko Koivisto; E A Nikkilä
Severity, duration, and mechanisms of insulin resistance during acute infections.
The Journal of clinical endocrinology and metabolism 1989;69(2):317-23.
1989: Hannele Yki-Järvinen; E Helve; Timo Sane; N Nurjhan; Marja-Riitta Taskinen
Insulin inhibition of overnight glucose production and gluconeogenesis from lactate in NIDDM.
The American journal of physiology 1989;256(6 Pt 1):E732-9.
1989: Hannele Yki-Järvinen; agostino consoli; N Nurjhan; Andrew A Young; J E Gerich
Mechanism for underestimation of isotopically determined glucose disposal.
Diabetes 1989;38(6):744-51.
1989: Marja-Riitta Taskinen; Timo Sane; E Helve; S L Karonen; E A Nikkilä; Hannele Yki-Järvinen
Bedtime insulin for suppression of overnight free-fatty acid, blood glucose, and glucose production in NIDDM.
Diabetes 1989;38(5):580-8.
1989: Tuomo Kuusi; M S Nieminen; Christian Ehnholm; Hannele Yki-Järvinen; M Valle; E A Nikkilä; Marja-Riitta Taskinen
Apoprotein E polymorphism and coronary artery disease. Increased prevalence of apolipoprotein E-4 in angiographically verified coronary patients.
Arteriosclerosis (Dallas, Tex.) 1989;9(2):237-41.
1989: A M Suikkari; Timo Sane; Markku Seppala; Hannele Yki-Järvinen; Sirkka-Liisa Karonen; Veikko Koivisto
Prolonged exercise increases serum insulin-like growth factor-binding protein concentrations.
The Journal of clinical endocrinology and metabolism 1989;68(1):141-4.
1989: A M Suikkari; Veikko Koivisto; Riitta Koistinen; Markku Seppala; Hannele Yki-Järvinen
Dose-response characteristics for suppression of low molecular weight plasma insulin-like growth factor-binding protein by insulin.
The Journal of clinical endocrinology and metabolism 1989;68(1):135-40.
1988: Hannele Yki-Järvinen; Marja-Riitta Taskinen
Interrelationships among insulin's antilipolytic and glucoregulatory effects and plasma triglycerides in nondiabetic and diabetic patients with endogenous hypertriglyceridemia.
Diabetes 1988;37(9):1271-8.
1988: Marja-Riitta Taskinen; Tuomo Kuusi; Hannele Yki-Järvinen; E A Nikkilä
Short-term effects of prednisone on serum lipids and high density lipoprotein subfractions in normolipidemic healthy men.
The Journal of clinical endocrinology and metabolism 1988;67(2):291-9.
1988: P Ebeling; Hannele Yki-Järvinen; A Aro; E Helve; M Sinisalo; Veikko Koivisto
Glucose and lipid metabolism and insulin sensitivity in type 1 diabetes: the effect of guar gum.
The American journal of clinical nutrition 1988;48(1):98-103.
1988: S Lillioja; DM Mott; B V Howard; Peter H Bennett; Hannele Yki-Järvinen; D Freymond; B L Nyomba; francesco zurlo; B Swinburn; Clifton Bogardus
Impaired glucose tolerance as a disorder of insulin action. Longitudinal and cross-sectional studies in Pima Indians.
The New England journal of medicine 1988;318(19):1217-25.
1988: Marja-Riitta Taskinen; Tuomo Kuusi; E Helve; E A Nikkilä; Hannele Yki-Järvinen
Insulin therapy induces antiatherogenic changes of serum lipoproteins in noninsulin-dependent diabetes.
Arteriosclerosis (Dallas, Tex.) 1988;8(2):168-77.
1988: Hannele Yki-Järvinen; Veikko Koivisto; R Ylikahri; Marja-Riitta Taskinen
Acute effects of ethanol and acetate on glucose kinetics in normal subjects.
The American journal of physiology 1988;254(2 Pt 1):E175-80.
1988: Hannele Yki-Järvinen; N Esko; H Eero; T Marja-Riitta
Clinical benefits and mechanisms of a sustained response to intermittent insulin therapy in type 2 diabetic patients with secondary drug failure.
The American journal of medicine 1988;84(2):185-92.
1988: A M Suikkari; Veikko Koivisto; E M Rutanen; Hannele Yki-Järvinen; Sirkka-Liisa Karonen; Markku Seppala
Insulin regulates the serum levels of low molecular weight insulin-like growth factor-binding protein.
The Journal of clinical endocrinology and metabolism 1988;66(2):266-72.
1987: V A Koivisto; Hannele Yki-Järvinen
Effect of exercise on insulin binding and glucose transport in adipocytes of normal humans.
Journal of applied physiology (Bethesda, Md. : 1985) 1987;63(4):1319-23.
1987: Hannele Yki-Järvinen; Clifton Bogardus; B V Howard
Hyperglycemia stimulates carbohydrate oxidation in humans.
The American journal of physiology 1987;253(4 Pt 1):E376-82.
1987: Hannele Yki-Järvinen; K Kubo; J Zawadzki; S Lillioja; A Young; W Abbott; J E Foley
Dissociation of in vitro sensitivities of glucose transport and antilipolysis to insulin in NIDDM.
The American journal of physiology 1987;253(3 Pt 1):E300-4.
1987: S Lillioja; A A Young; C L Culter; J L Ivy; W G Abbott; J K Zawadzki; Hannele Yki-Järvinen; L Christin; Timothy Secomb; Clifton Bogardus
Skeletal muscle capillary density and fiber type are possible determinants of in vivo insulin resistance in man.
The Journal of clinical investigation 1987;80(2):415-24.
1987: W G Abbott; S Lillioja; Andrew A Young; J K Zawadzki; Hannele Yki-Järvinen; L Christin; B V Howard
Relationships between plasma lipoprotein concentrations and insulin action in an obese hyperinsulinemic population.
Diabetes 1987;36(8):897-904.
1987: Hannele Yki-Järvinen; E Helve; V A Koivisto
Hyperglycemia decreases glucose uptake in type I diabetes.
Diabetes 1987;36(8):892-6.
1987: Hannele Yki-Järvinen; D Mott; A A Young; K Stone; Clifton Bogardus
Regulation of glycogen synthase and phosphorylase activities by glucose and insulin in human skeletal muscle.
The Journal of clinical investigation 1987;80(1):95-100.
1987: Hannele Yki-Järvinen; A A Young; C Lamkin; J E Foley
Kinetics of glucose disposal in whole body and across the forearm in man.
The Journal of clinical investigation 1987;79(6):1713-9.
1986: V A Koivisto; Hannele Yki-Järvinen; S G Hartling; R Pelkonen
The effect of exogenous hyperinsulinemia on proinsulin secretion in normal man, obese subjects, and patients with insulinoma.
The Journal of clinical endocrinology and metabolism 1986;63(5):1117-20.
1986: E Helve; Hannele Yki-Järvinen; V A Koivisto
Smoking and insulin sensitivity in type I diabetic patients.
Metabolism: clinical and experimental 1986;35(9):874-7.
1986: Hannele Yki-Järvinen; T Kiviluoto; M R Taskinen
Insulin resistance is a prominent feature of patients with pancreatogenic diabetes.
Metabolism: clinical and experimental 1986;35(8):718-27.
1986: Hannele Yki-Järvinen; V A Koivisto
Natural course of insulin resistance in type I diabetes.
The New England journal of medicine 1986;315(4):224-30.
1986: Hannele Yki-Järvinen; E Helve; V A Koivisto
Relationship between oral glucose tolerance and insulin sensitivity in healthy man and type 1 diabetic patients.
Acta endocrinologica 1986;112(3):355-60.
1986: Hannele Yki-Järvinen; E A Nikkilä; K Kubo; J E Foley
Assay of glucose transport in human fat cells obtained by needle biopsy.
Diabetologia 1986;29(5):287-90.
1986: Hannele Yki-Järvinen; E Helve; L Laatikainen; S L Karonen; V A Koivisto
No association between retinopathy and insulin resistance in type 1 diabetes.
Acta endocrinologica 1986;111(4):522-7.
1986: V A Koivisto; Hannele Yki-Järvinen; Ralph DeFronzo
Physical training and insulin sensitivity.
Diabetes/metabolism reviews 1986;1(4):445-81.
1986: Veikko Koivisto; Hannele Yki-Järvinen; E Helve; S L Karonen; R Pelkonen
Pathogenesis and prevention of the dawn phenomenon in diabetic patients treated with CSII.
Diabetes 1986;35(1):78-82.
1986: V A Koivisto; Hannele Yki-Järvinen; E Helve
[Insulin resistance in type I diabetes].
Journées annuelles de diabétologie de l'Hôtel-Dieu 1986;():155-63.
1985: Hannele Yki-Järvinen; E A Nikkilä
Ethanol decreases glucose utilization in healthy man.
The Journal of clinical endocrinology and metabolism 1985;61(5):941-5.
1985: Hannele Yki-Järvinen; R Pelkonen; V A Koivisto
Failure to suppress C-peptide secretion by euglycaemic hyperinsulinaemia: a new diagnostic test for insulinoma?
Clinical endocrinology 1985;23(4):461-6.
1985: Hannele Yki-Järvinen; V A Koivisto; S L Karonen
Influence of body composition on insulin clearance.
Clinical physiology (Oxford, England) 1985;5(1):45-52.
1985: Hannele Yki-Järvinen; T Wahlström; Markku Seppala
Human endometrium contains relaxin that is progesterone-dependent.
Acta obstetricia et gynecologica Scandinavica 1985;64(8):663-5.
1985: T Wahlström; A I Koskimies; A Tenhunen; E M Rutanen; Hannele Yki-Järvinen; M Julkunen; Jari Sjöberg; Markku Seppala
Pregnancy proteins in the endometrium after follicle aspiration for in vitro fertilization.
Annals of the New York Academy of Sciences 1985;442():402-7.
1984: Hannele Yki-Järvinen; Marja-Riitta Taskinen; T Kiviluoto; H Hilden; E Helve; Veikko Koivisto; E A Nikkilä
Site of insulin resistance in type 1 diabetes: insulin-mediated glucose disposal in vivo in relation to insulin binding and action in adipocytes in vitro.
The Journal of clinical endocrinology and metabolism 1984;59(6):1183-92.
1984: Hannele Yki-Järvinen; Ralph DeFronzo; V A Koivisto
Normalization of insulin sensitivity in type I diabetic subjects by physical training during insulin pump therapy.
Diabetes care 1984;7(6):520-7.
1984: Hannele Yki-Järvinen
Sex and insulin sensitivity.
Metabolism: clinical and experimental 1984;33(11):1011-5.
1984: Hannele Yki-Järvinen; T Wahlström; A Tenhunen; A I Koskimies; Markku Seppala
The occurrence of relaxin in hyperstimulated human preovulatory follicles collected in an in vitro fertilization program.
Journal of in vitro fertilization and embryo transfer : IVF 1984;1(3):180-2.
1984: Hannele Yki-Järvinen; V A Koivisto
Insulin sensitivity in newly diagnosed type 1 diabetics after ketoacidosis and after three months of insulin therapy.
The Journal of clinical endocrinology and metabolism 1984;59(3):371-8.
1984: Hannele Yki-Järvinen; M R Taskinen; V A Koivisto; E A Nikkilä
Response of adipose tissue lipoprotein lipase activity and serum lipoproteins to acute hyperinsulinaemia in man.
Diabetologia 1984;27(3):364-9.
1984: Hannele Yki-Järvinen; T Wahlström
Immunohistochemical demonstration of relaxin in the placenta after removal of the corpus luteum.
Acta endocrinologica 1984;106(4):544-7.
1984: Hannele Yki-Järvinen
Insulin sensitivity during the menstrual cycle.
The Journal of clinical endocrinology and metabolism 1984;59(2):350-3.
1984: Hannele Yki-Järvinen; V A Koivisto
Continuous subcutaneous insulin infusion therapy decreases insulin resistance in type 1 diabetes.
The Journal of clinical endocrinology and metabolism 1984;58(4):659-66.
1984: Hannele Yki-Järvinen; V A Koivisto; M R Taskinen; E Nikkilä
Glucose tolerance, plasma lipoproteins and tissue lipoprotein lipase activities in body builders.
European journal of applied physiology and occupational physiology 1984;53(3):253-9.
1984: Hannele Yki-Järvinen; V A Koivisto
Insulin resistance in type I diabetes: prevalence, pathogenesis and therapeutic approaches.
Annals of clinical research 1984;16(2):74-83.
1983: Hannele Yki-Järvinen; T Wahlström; Markku Seppala
Immunohistochemical demonstration of relaxin in gynecologic tumors.
Cancer 1983;52(11):2077-80.
1983: Hannele Yki-Järvinen; T Wahlström; Markku Seppala
Immunohistochemical demonstration of relaxin in the genital tract of men.
Journal of reproduction and fertility 1983;69(2):693-5.
1983: Hannele Yki-Järvinen; V A Koivisto
Effects of body composition on insulin sensitivity.
Diabetes 1983;32(10):965-9.
1983: Hannele Yki-Järvinen; T Wahlström; Markku Seppala
Immunohistochemical demonstration of relaxin in the genital tract of pregnant and nonpregnant women.
The Journal of clinical endocrinology and metabolism 1983;57(3):451-4.
1979: Hannele Yki-Järvinen; I Kouvonen; Ralph Gustaf Grasbeck
Solubilization and preliminary characterization of the human ileal vitamin B12-intrinsic factor receptor.
Scandinavian journal of clinical and laboratory investigation 1979;39(5):461-7.