Jonathan Chaires

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Garbett Nichola C; Mekmaysy Chongkham S; Helm C William; Jenson A Bennett; Chaires Jonathan B
Differential scanning calorimetry of blood plasma for clinical diagnosis and monitoring.
Gray Robert D; Li Jing; Chaires Jonathan B
Energetics and kinetics of a conformational switch in G-quadruplex DNA.
Benight Albert S; Chaires Jonathan B
Tribute for j. Michael schurr.

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2009: Garbett Nichola C; Mekmaysy Chongkham S; Helm C William; Jenson A Bennett; Chaires Jonathan B
Differential scanning calorimetry of blood plasma for clinical diagnosis and monitoring.
Experimental and molecular pathology 2009;86(3):186-91.
2009: Gray Robert D; Li Jing; Chaires Jonathan B
Energetics and kinetics of a conformational switch in G-quadruplex DNA.
The journal of physical chemistry. B 2009;113(9):2676-83.
2009: Benight Albert S; Chaires Jonathan B
Tribute for j. Michael schurr.
The journal of physical chemistry. B 2009;113(9):2543-4.
2009: Holt Patrick A; Ragazzon Patricia; Strekowski Lucjan; Chaires Jonathan B; Trent John O
Discovery of novel triple helical DNA intercalators by an integrated virtual and actual screening platform.
Nucleic acids research 2009;37(4):1280-7.
2008: Petraccone Luigi; Trent John O; Chaires Jonathan B
The tail of the telomere.
Journal of the American Chemical Society 2008;130(49):16530-2.
2008: Yu Haijia; Ren Jinsong; Chaires Jonathan B; Qu Xiaogang
Hydration of drug-DNA complexes: greater water uptake for adriamycin compared to daunomycin.
Journal of medicinal chemistry 2008;51(19):5909-11.
2008: Lane Andrew N; Chaires J Brad; Gray Robert D; Trent John O
Stability and kinetics of G-quadruplex structures.
Nucleic acids research 2008;36(17):5482-515.
2008: Holt Patrick A; Chaires Jonathan B; Trent John O
Molecular docking of intercalators and groove-binders to nucleic acids using Autodock and Surflex.
Journal of chemical information and modeling 2008;48(8):1602-15.
2008: Gray Robert D; Chaires Jonathan B
Kinetics and mechanism of K+- and Na+-induced folding of models of human telomeric DNA into G-quadruplex structures.
Nucleic acids research 2008;36(12):4191-203.
2008: Chaires Jonathan B; Mergny Jean-Louis
Targeting DNA.
Biochimie 2008;90(7):973-5.
2008: Mekmaysy Chongkham S; Petraccone Luigi; Garbett Nichola C; Ragazzon Patricia A; Gray Robert; Trent John O; Chaires Jonathan B
Effect of O6-methylguanine on the stability of G-quadruplex DNA.
Journal of the American Chemical Society 2008;130(21):6710-1.
2008: Chaires Jonathan B
Allostery: DNA does it, too.
ACS chemical biology 2008;3(4):207-9.
2008: Garbett Nichola C; Miller James J; Jenson Alfred B; Chaires Jonathan B
Calorimetry outside the box: a new window into the plasma proteome.
Biophysical journal 2008;94(4):1377-83.
2008: Chaires Jonathan B
Calorimetry and thermodynamics in drug design.
Annual review of biophysics 2008;37():135-51.
2008: Garbett Nichola C; Chaires Jonathan B
Binding: a polemic and rough guide.
Methods in cell biology 2008;84():3-23.
2007: Ragazzon Patricia; Chaires Jonathan B
Use of competition dialysis in the discovery of G-quadruplex selective ligands.
Methods (San Diego, Calif.) 2007;43(4):313-23.
2007: Garbett Nichola C; Miller James J; Jenson A Bennett; Chaires Jonathan B
Calorimetric analysis of the plasma proteome.
Seminars in nephrology 2007;27(6):621-6.
2007: Garbett Nichola C; Miller James J; Jenson A Bennett; Miller Donald M; Chaires Jonathan B
Interrogation of the plasma proteome with differential scanning calorimetry.
Clinical chemistry 2007;53(11):2012-4.
2007: Dignam John David; Qu Xiaogang; Ren Jinsong; Chaires Jonathan B
Daunomycin binding to detergent micelles: a model system for evaluating the hydrophobic contribution to drug-DNA interactions.
The journal of physical chemistry. B 2007;111(39):11576-84.
2007: Ragazzon Patricia A; Garbett Nichola C; Chaires Jonathan B
Competition dialysis: a method for the study of structural selective nucleic acid binding.
Methods (San Diego, Calif.) 2007;42(2):173-82.
2007: Antonacci Cosimo; Chaires Jonathan B; Sheardy Richard D
Biophysical characterization of the human telomeric (TTAGGG)4 repeat in a potassium solution.
Biochemistry 2007;46(15):4654-60.
2007: Spink Charles H; Garbett Nichola; Chaires Jonathan B
Enthalpies of DNA melting in the presence of osmolytes.
Biophysical chemistry 2007;126(1-3):176-85.
2007: Bishop G Reid; Ren Jinsong; Polander Brandon C; Jeanfreau Benjamin D; Trent John O; Chaires Jonathan B
Energetic basis of molecular recognition in a DNA aptamer.
Biophysical chemistry 2007;126(1-3):165-75.
2007: Garbett Nichola C; Ragazzon Patricia A; Chaires Jonathan B
Circular dichroism to determine binding mode and affinity of ligand-DNA interactions.
Nature protocols 2007;2(12):3166-72.
2006: Grant LaKechia; Sun Jun; Xu Hongzhi; Subramony S H; Chaires Jonathan B; Hebert Michael D
Rational selection of small molecules that increase transcription through the GAA repeats found in Friedreich's ataxia.
FEBS letters 2006;580(22):5399-405.
2006: Chaires Jonathan B
A thermodynamic signature for drug-DNA binding mode.
Archives of biochemistry and biophysics 2006;453(1):26-31.
2006: Wheelhouse Richard T; Jennings Sharon A; Phillips Victoria A; Pletsas Dimitrios; Murphy Peter M; Garbett Nichola C; Chaires Jonathan B; Jenkins Terence C
Design, synthesis, and evaluation of novel biarylpyrimidines: a new class of ligand for unusual nucleic acid structures.
Journal of medicinal chemistry 2006;49(17):5187-98.
2006: Nagarajan Muthukaman; Morrell Andrew; Antony Smitha; Kohlhagen Glenda; Agama Keli; Pommier Yves; Ragazzon Patricia A; Garbett Nichola C; Chaires Jonathan B; Hollingshead Melinda; Cushman Mark
Synthesis and biological evaluation of bisindenoisoquinolines as topoisomerase I inhibitors.
Journal of medicinal chemistry 2006;49(17):5129-40.
2006: Shi Xiaochun; Chaires Jonathan B
Sequence- and structural-selective nucleic acid binding revealed by the melting of mixtures.
Nucleic acids research 2006;34(2):e14.
2005: Portugal José; Cashman Derek J; Trent John O; Ferrer-Miralles Neus; Przewloka Teresa; Fokt Izabela; Priebe Waldemar; Chaires Jonathan B
A new bisintercalating anthracycline with picomolar DNA binding affinity.
Journal of medicinal chemistry 2005;48(26):8209-19.
2005: Xing Feifei; Song Guangtao; Ren Jinsong; Chaires Jonathan B; Qu Xiaogang
Molecular recognition of nucleic acids: coralyne binds strongly to poly(A).
FEBS letters 2005;579(22):5035-9.
2005: Chaires Jonathan B
Competition dialysis: an assay to measure the structural selectivity of drug-nucleic acid interactions.
Current medicinal chemistry. Anti-cancer agents 2005;5(4):339-52.
2005: Song Guangtao; Xing Feifei; Qu Xiaogang; Chaires Jonathan B; Ren Jinsong
Oxazine 170 induces DNA:RNA:DNA triplex formation.
Journal of medicinal chemistry 2005;48(10):3471-3.
2005: Mergny Jean-Louis; Li Jing; Lacroix Laurent; Amrane Samir; Chaires Jonathan B
Thermal difference spectra: a specific signature for nucleic acid structures.
Nucleic acids research 2005;33(16):e138.
2005: Li Jing; Correia John J; Wang Lei; Trent John O; Chaires Jonathan B
Not so crystal clear: the structure of the human telomere G-quadruplex in solution differs from that present in a crystal.
Nucleic acids research 2005;33(14):4649-59.
2004: Chaires Jonathan B; Ren Jinsong; Hamelberg Donald; Kumar Arvind; Pandya Vandna; Boykin David W; Wilson W David
Structural selectivity of aromatic diamidines.
Journal of medicinal chemistry 2004;47(23):5729-42.
2003: Leng Fenfei; Chaires Jonathan B; Waring Michael J
Energetics of echinomycin binding to DNA.
Nucleic acids research 2003;31(21):6191-7.
2003: Qu Xiaogang; Ren Jinsong; Riccelli Peter V; Benight Albert S; Chaires Jonathan B
Enthalpy/entropy compensation: influence of DNA flanking sequence on the binding of 7-amino actinomycin D to its primary binding site in short DNA duplexes.
Biochemistry 2003;42(41):11960-7.
2003: Chaires Jonathan B; Ren Jinsong; Henary Maged; Zegrocka Oliwia; Bishop G Reid; Strekowski Lucjan
Triplex selective 2-(2-naphthyl)quinoline compounds: origins of affinity and new design principles.
Journal of the American Chemical Society 2003;125(24):7272-83.
2003: Murphy Peter M; Phillips Victoria A; Jennings Sharon A; Garbett Nichola C; Chaires Jonathan B; Jenkins Terence C; Wheelhouse Richard T
Biarylpyrimidines: a new class of ligand for high-order DNA recognition.
Chemical communications (Cambridge, England) 2003;(10):1160-1.
2003: Dignam John David; Nada Shadia; Chaires Jonathan B
Thermodynamic characterization of the binding of nucleotides to glycyl-tRNA synthetase.
Biochemistry 2003;42(18):5333-40.
2003: Chaires Jonathan B
A competition dialysis assay for the study of structure-selective ligand binding to nucleic acids.
Current protocols in nucleic acid chemistry / edited by Serge L. Beaucage ... [et al.] 2003;Chapter 8():Unit 8.3.
2003: Bishop G Reid; Chaires Jonathan B
Characterization of DNA structures by circular dichroism.
Current protocols in nucleic acid chemistry / edited by Serge L. Beaucage ... [et al.] 2003;Chapter 7():Unit 7.11.
2003: Reynisson Jóhannes; Schuster Gary B; Howerton Sheldon B; Williams Loren Dean; Barnett Robert N; Cleveland Charles L; Landman Uzi; Harrit Niels; Chaires Jonathan B
Intercalation of trioxatriangulenium ion in DNA: binding, electron transfer, x-ray crystallography, and electronic structure.
Journal of the American Chemical Society 2003;125(8):2072-83.
2002: Carrasco Carolina; Rosu Frédéric; Gabelica Valérie; Houssier Claude; De Pauw Edwin; Garbay-Jaureguiberry Christiane; Roques Bernard; Wilson W David; Chaires Jonathan B; Waring Michael J; Bailly Christian
Tight binding of the antitumor drug ditercalinium to quadruplex DNA.
Chembiochem : a European journal of chemical biology 2002;3(12):1235-41.
2002: Suh Dongchul; Oh Yu-Kyoung; Hur Man-Wook; Ahn Byungchan; Chaires Jonathan B
Daunomycin binding to deoxypolynucleotides with alternating sequences: complete thermodynamic profiles of heterogeneous binding sites.
Nucleosides, nucleotides & nucleic acids 2002;21(10):637-49.
2002: Ren Jinsong; Qu Xiaogang; Trent John O; Chaires Jonathan B
Tiny telomere DNA.
Nucleic acids research 2002;30(11):2307-15.
2001: Alberti P; Ren J; Teulade-Fichou M P; Guittat L; Riou J F; Chaires J; Hélène C; Vigneron J P; Lehn J M; Mergny J L
Interaction of an acridine dimer with DNA quadruplex structures.
Journal of biomolecular structure & dynamics 2001;19(3):505-13.
2001: Carrasco C; Vezin H; Wilson W D; Ren J; Chaires J B; Bailly C
DNA binding properties of the indolocarbazole antitumor drug NB-506.
Anti-cancer drug design 2001;16(2-3):99-107.
2001: Dignam J D; Qu X; Chaires J B
Equilibrium unfolding of Bombyx mori glycyl-tRNA synthetase.
The Journal of biological chemistry 2001;276(6):4028-37.
2001: Qu X; Chaires J B
Hydration changes for DNA intercalation reactions.
Journal of the American Chemical Society 2001;123(1):1-7.
2001: Ren J; Chaires J B
Rapid screening of structurally selective ligand binding to nucleic acids.
Methods in enzymology 2001;340():99-108.
2001: Priebe W; Fokt I; Przewloka T; Chaires J B; Portugal J; Trent J O
Exploiting anthracycline scaffold for designing DNA-targeting agents.
Methods in enzymology 2001;340():529-55.
2001: Chaires J B
Analysis and interpretation of ligand-DNA binding isotherms.
Methods in enzymology 2001;340():3-22.
2000: Bailly C; Goossens J F; Laine W; Anizon F; Prudhomme M; Ren J; Chaires J B
Formaldehyde-induced alkylation of a 2'-aminoglucose rebeccamycin derivative to both A.T and G.C base pairs in DNA.
Journal of medicinal chemistry 2000;43(24):4711-20.
2000: Qu X; Trent J O; Fokt I; Priebe W; Chaires J B
Allosteric, chiral-selective drug binding to DNA.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(22):12032-7.
2000: Ren J; Jenkins T C; Chaires J B
Energetics of DNA intercalation reactions.
Biochemistry 2000;39(29):8439-47.
2000: Ren J; Bailly C; Chaires J B
NB-506, an indolocarbazole topoisomerase I inhibitor, binds preferentially to triplex DNA.
FEBS letters 2000;470(3):355-9.
2000: Qu X; Chaires J B
Analysis of drug-DNA binding data.
Methods in enzymology 2000;321():353-69.
1999: Ren J; Chaires J B
Sequence and structural selectivity of nucleic acid binding ligands.
Biochemistry 1999;38(49):16067-75.
1999: Qu X; Chaires J B; Ohkubo M; Yoshinari T; Nishimura S; Bailly C
A DNA binding indolocarbazole disaccharide derivative remains highly cytotoxic without inhibiting topoisomerase I.
Anti-cancer drug design 1999;14(5):433-42.
1999: Bailly C; Qu X; Chaires J B; Colson P; Houssier C; Ohkubo M; Nishimura S; Yoshinari T
Substitution at the F-ring N-imide of the indolocarbazole antitumor drug NB-506 increases the cytotoxicity, DNA binding, and topoisomerase I inhibition activities.
Journal of medicinal chemistry 1999;42(15):2927-35.
1999: Bailly C; Qu X; Graves D E; Prudhomme M; Chaires J B
Calories from carbohydrates: energetic contribution of the carbohydrate moiety of rebeccamycin to DNA binding and the effect of its orientation on topoisomerase I inhibition.
Chemistry & biology 1999;6(5):277-86.
1999: Ren J; Qu X; Chaires J B; Trempe J P; Dignam S S; Dignam J D
Spectral and physical characterization of the inverted terminal repeat DNA structure from adenoassociated virus 2.
Nucleic acids research 1999;27(9):1985-90.
1999: Bailly C; Qu X; Anizon F; Prudhomme M; Riou J F; Chaires J B
Enhanced binding to DNA and topoisomerase I inhibition by an analog of the antitumor antibiotic rebeccamycin containing an amino sugar residue.
Molecular pharmacology 1999;55(2):377-85.
1999: Spink C H; Chaires J B
Effects of hydration, ion release, and excluded volume on the melting of triplex and duplex DNA.
Biochemistry 1999;38(1):496-508.
1998: Leng F; Graves D; Chaires J B
Chemical cross-linking of ethidium to DNA by glyoxal.
Biochimica et biophysica acta 1998;1442(1):71-81.
1998: Chaires J B
Drug--DNA interactions.
Current opinion in structural biology 1998;8(3):314-20.
1998: Leng F; Priebe W; Chaires J B
Ultratight DNA binding of a new bisintercalating anthracycline antibiotic.
Biochemistry 1998;37(7):1743-53.
1998: Bailly C; Suh D; Waring M J; Chaires J B
Binding of daunomycin to diaminopurine- and/or inosine-substituted DNA.
Biochemistry 1998;37(4):1033-45.
1997: Hu G G; Shui X; Leng F; Priebe W; Chaires J B; Williams L D
Structure of a DNA-bisdaunomycin complex.
Biochemistry 1997;36(20):5940-6.
1997: Chaires J B
Possible origin of differences between van't Hoff and calorimetric enthalpy estimates.
Biophysical chemistry 1997;64(1-3):15-23.
1997: Chaires J B; Leng F; Przewloka T; Fokt I; Ling Y H; Perez-Soler R; Priebe W
Structure-based design of a new bisintercalating anthracycline antibiotic.
Journal of medicinal chemistry 1997;40(3):261-6.
1997: Chaires J B
Energetics of drug-DNA interactions.
Biopolymers 1997;44(3):201-15.
1996: Chaires J B
Dissecting the free energy of drug binding to DNA.
Anti-cancer drug design 1996;11(8):569-80.
1996: Chaires J B; Satyanarayana S; Suh D; Fokt I; Przewloka T; Priebe W
Parsing the free energy of anthracycline antibiotic binding to DNA.
Biochemistry 1996;35(7):2047-53.
1995: Suh D; Chaires J B
Criteria for the mode of binding of DNA binding agents.
Bioorganic & medicinal chemistry 1995;3(6):723-8.
1994: Falzon L; Kirk C; Chaires J B; Dabrowiak J C
PCR generation of large amounts of purified DNA.
Journal of biochemical and biophysical methods 1994;29(3-4):251-7.
1994: Sheardy R D; Levine N; Marotta S; Suh D; Chaires J B
A thermodynamic investigation of the melting of B-Z junction forming DNA oligomers.
Biochemistry 1994;33(6):1385-91.
1994: Herrera J E; Chaires J B
Characterization of preferred deoxyribonuclease I cleavage sites.
Journal of molecular biology 1994;236(2):405-11.
1994: Wellman S E; Sittman D B; Chaires J B
Preferential binding of H1e histone to GC-rich DNA.
Biochemistry 1994;33(1):384-8.
1994: Correia J J; Chaires J B
Analysis of drug-DNA binding isotherms: a Monte Carlo approach.
Methods in enzymology 1994;240():593-614.
1993: Sheardy R D; Suh D; Kurzinsky R; Doktycz M J; Benight A S; Chaires J B
Sequence dependence of the free energy of B-Z junction formation in deoxyoligonucleotides.
Journal of molecular biology 1993;231(2):475-88.
1993: Satyanarayana S; Dabrowiak J C; Chaires J B
Tris(phenanthroline)ruthenium(II) enantiomer interactions with DNA: mode and specificity of binding.
Biochemistry 1993;32(10):2573-84.
1992: Satyanarayana S; Dabrowiak J C; Chaires J B
Neither delta- nor lambda-tris(phenanthroline)ruthenium(II) binds to DNA by classical intercalation.
Biochemistry 1992;31(39):9319-24.
1991: Gilbert P L; Graves D E; Britt M; Chaires J B
Inhibition of the B to Z transition in poly(dGdC).poly(dGdC) by covalent attachment of ethidium: kinetic studies.
Biochemistry 1991;30(45):10931-7.
1991: Gilbert P L; Graves D E; Chaires J B
Inhibition of the B to Z transition in poly(dGdC).poly(dGdC) by covalent attachment of ethidium: equilibrium studies.
Biochemistry 1991;30(45):10925-31.
1991: Suh D; Sheardy R D; Chaires J B
Unusual binding of ethidium to a deoxyoligonucleotide containing a B-Z junction.
Biochemistry 1991;30(36):8722-6.
1990: Chaires J B; Herrera J E; Waring M J
Preferential binding of daunomycin to 5'ATCG and 5'ATGC sequences revealed by footprinting titration experiments.
Biochemistry 1990;29(26):6145-53.
1990: Chaires J B
Biophysical chemistry of the daunomycin-DNA interaction.
Biophysical chemistry 1990;35(2-3):191-202.
1989: Herrera J E; Chaires J B
A premelting conformational transition in poly(dA)-Poly(dT) coupled to daunomycin binding.
Biochemistry 1989;28(5):1993-2000.
1988: Chaires J B; Norcum M T
Structure and stability of Z* DNA.
Journal of biomolecular structure & dynamics 1988;5(6):1187-207.
1988: Chaires J B; Herrera J; Britt M; Fox K R; Waring M J
Sequence specificity of the daunomycin-DNA interaction.
Biochemical pharmacology 1988;37(9):1785-6.
1987: Chaires J B; Fox K R; Herrera J E; Britt M; Waring M J
Site and sequence specificity of the daunomycin-DNA interaction.
Biochemistry 1987;26(25):8227-36.
1986: Britt M; Zunino F; Chaires J B
The interaction of the beta-anomer of doxorubicin with B and Z DNA.
Molecular pharmacology 1986;29(1):74-80.

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Jonathan Chaires

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