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Richard Frank Cowburn

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Lin Zheng; Alexei Terman; Eirikur Benedikz; Angel Cedazo-Minguez; Richard Frank Cowburn; Nodi Dehvari; Martin Hallbeck; Katarina Kågedal; Jan Marcusson
Macroautophagy-generated increase of lysosomal amyloid β-protein mediates oxidant-induced apoptosis of cultured neuroblastoma cells.
Anna Sandebring; Nodi Dehvari; Monica Perez-Manso; Kelly Jean Thomas; Elena Karpilovski; Mark Cookson; Richard Frank Cowburn; Angel Cedazo-Mínguez
Parkin deficiency disrupts calcium homeostasis by modulating phospholipase C signalling.
Nodi Dehvari; Anna Sandebring; Amilcar Flores-Morales; Laura Mateos; Yin-Choy Chuan; Matthew S Goldberg; Mark Cookson; Richard Frank Cowburn; Angel Cedazo-Mínguez
Parkin-mediated ubiquitination regulates phospholipase C-gamma1.

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2011: Lin Zheng; Alexei Terman; Eirikur Benedikz; Angel Cedazo-Minguez; Richard Frank Cowburn; Nodi Dehvari; Martin Hallbeck; Katarina Kågedal; Jan Marcusson
Macroautophagy-generated increase of lysosomal amyloid β-protein mediates oxidant-induced apoptosis of cultured neuroblastoma cells.
Autophagy 2011;7(12):1528-45.
2009: Anna Sandebring; Nodi Dehvari; Monica Perez-Manso; Kelly Jean Thomas; Elena Karpilovski; Mark Cookson; Richard Frank Cowburn; Angel Cedazo-Mínguez
Parkin deficiency disrupts calcium homeostasis by modulating phospholipase C signalling.
The FEBS journal 2009;276(18):5041-52.
2009: Nodi Dehvari; Anna Sandebring; Amilcar Flores-Morales; Laura Mateos; Yin-Choy Chuan; Matthew S Goldberg; Mark Cookson; Richard Frank Cowburn; Angel Cedazo-Mínguez
Parkin-mediated ubiquitination regulates phospholipase C-gamma1.
Journal of cellular and molecular medicine 2009;13(9B):3061-8.
2009: Anna Sandebring; Kelly Jean Thomas; Alexandra Beilina; Marcel van der Brug; Megan Cleland; Rili Ahmad; David W Miller; Ibardo Zambrano; Richard Frank Cowburn; Homira Behbahani; Angel Cedazo-Mínguez; Mark Cookson
Mitochondrial alterations in PINK1 deficient cells are influenced by calcineurin-dependent dephosphorylation of dynamin-related protein 1.
PloS one 2009;4(5):e5701.
2008: Nodi Dehvari; Ola Isacsson; Bengt Winblad; Angel Cedazo-Minguez; Richard Frank Cowburn
Presenilin regulates extracellular regulated kinase (Erk) activity by a protein kinase C alpha dependent mechanism.
Neuroscience letters 2008;436(1):77-80.
2007: Richard Frank Cowburn; Bogdan O Popescu; Maria Ankarcrona; Nodi Dehvari; Angel Cedazo-Minguez
Presenilin-mediated signal transduction.
Physiology & behavior 2007;92(1-2):93-7.
2007: Nodi Dehvari; Angel Cedazo-Minguez; Ola Isacsson; Tatjana Nilsson; Bengt Winblad; Helena Karlström; Eirikur Benedikz; Richard Frank Cowburn
Presenilin dependence of phospholipase C and protein kinase C signaling.
Journal of neurochemistry 2007;102(3):848-57.
2006: Homira Behbahani; Irina Shabalina; Birgitta Wiehager; Hérnan Concha; Kjell Hultenby; Natasa Petrovic; Jan Nedergaard; Bengt Winblad; Richard Frank Cowburn; Maria Ankarcrona
Differential role of Presenilin-1 and -2 on mitochondrial membrane potential and oxygen consumption in mouse embryonic fibroblasts.
Journal of neuroscience research 2006;84(4):891-902.
2006: Susanne Akterin; Richard Frank Cowburn; Antonio Miranda-Vizuete; Alberto Jiménez; Nenad Bogdanovic; Bengt Winblad; Angel Cedazo-Minguez
Involvement of glutaredoxin-1 and thioredoxin-1 in beta-amyloid toxicity and Alzheimer's disease.
Cell death and differentiation 2006;13(9):1454-65.
2006: Annika Rickle; Homira Behbahani; Maria Ankarcrona; Bengt Winblad; Richard Frank Cowburn
PTEN, Akt, and GSK3beta signalling in rat primary cortical neuronal cultures following tumor necrosis factor-alpha and trans-4-hydroxy-2-nonenal treatments.
Journal of neuroscience research 2006;84(3):596-605.
2006: Sara Johansson; Anne Jämsä; Mervi Vasänge; Bengt Winblad; Johan Luthman; Richard Frank Cowburn
Increased tau phosphorylation at the Ser396 epitope after amyloid beta-exposure in organotypic cultures.
Neuroreport 2006;17(9):907-11.
2006: Anne Jämsä; Anders Bäckström; Elin Gustafsson; Nodi Dehvari; Gösta Hiller; Richard Frank Cowburn; Mervi Vasänge
Glutamate treatment and p25 transfection increase Cdk5 mediated tau phosphorylation in SH-SY5Y cells.
Biochemical and biophysical research communications 2006;345(1):324-31.
2006: J Holzmann; Nina Brandl; A Zemann; R Schabus; S Marlovits; Richard Frank Cowburn; Manfred Huettinger
Assorted effects of TGFbeta and chondroitinsulfate on p38 and ERK1/2 activation levels in human articular chondrocytes stimulated with LPS.
Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society 2006;14(6):519-25.
2006: Fiona Kerr; Annika Rickle; Naushaba Nayeem; Sebastian Brandner; Richard Frank Cowburn; Simon Lovestone
PTEN, a negative regulator of PI3 kinase signalling, alters tau phosphorylation in cells by mechanisms independent of GSK-3.
FEBS letters 2006;580(13):3121-8.
2006: Eric Murphy; hsueh huang; Richard Frank Cowburn; Lars Lannfelt; Gary E Gibson
Phospholipid mass is increased in fibroblasts bearing the Swedish amyloid precursor mutation.
Brain research bulletin 2006;69(1):79-85.
2006: Annika Rickle; Nenad Bogdanovic; Inga Volkmann; Xinwen Zhou; Jin-Jing Pei; Bengt Winblad; Richard Frank Cowburn
PTEN levels in Alzheimer's disease medial temporal cortex.
Neurochemistry international 2006;48(2):114-23.
2006: Sara Johansson; Ann-Cathrin Radesäter; Richard Frank Cowburn; Johan Thyberg; Johan Luthman
Modelling of amyloid beta-peptide induced lesions using roller-drum incubation of hippocampal slice cultures from neonatal rats.
Experimental brain research. Experimentelle Hirnforschung. Expérimentation cérébrale 2006;168(1-2):11-24.
2005: Homira Behbahani; Annika Rickle; H Concha; Maria Ankarcrona; Bengt Winblad; Richard Frank Cowburn
Flow cytometry as a method for studying effects of stressors on primary rat neurons.
Journal of neuroscience research 2005;82(3):432-41.
2005: Wen-Lin An; Jin-Jing Pei; Takeshi Nishimura; Bengt Winblad; Richard Frank Cowburn
Zinc-induced anti-apoptotic effects in SH-SY5Y neuroblastoma cells via the extracellular signal-regulated kinase 1/2.
Brain research. Molecular brain research 2005;135(1-2):40-7.
2005: Wen-Lin An; Cecilia Bjorkdahl; Rong Liu; Richard Frank Cowburn; Bengt Winblad; Jin-Jing Pei
Mechanism of zinc-induced phosphorylation of p70 S6 kinase and glycogen synthase kinase 3beta in SH-SY5Y neuroblastoma cells.
Journal of neurochemistry 2005;92(5):1104-15.
2005: Fiona Flood; Suzanne Murphy; Richard Frank Cowburn; Lars Lannfelt; Brian Walker; Janet A Johnston
Proteasome-mediated effects on amyloid precursor protein processing at the gamma-secretase site.
The Biochemical journal 2005;385(Pt 2):545-50.
2004: Camilla A Hansson; Susanne Frykman; Mark Farmery; Lars O Tjernberg; Camilla Nilsberth; Sharon E Pursglove; Akira Ito; Bengt Winblad; Richard Frank Cowburn; Johan Thyberg; Maria Ankarcrona
Nicastrin, presenilin, APH-1, and PEN-2 form active gamma-secretase complexes in mitochondria.
The Journal of biological chemistry 2004;279(49):51654-60.
2004: B Kostyszyn; Richard Frank Cowburn; Ake Seiger; Anders Kjaeldgaard; Erik Sundström
Distribution of presenilin 1 and 2 and their relation to Notch receptors and ligands in human embryonic/foetal central nervous system.
Brain research. Developmental brain research 2004;151(1-2):75-86.
2004: Anne Jämsä; Kristina Hasslund; Richard Frank Cowburn; Anders Bäckström; Mervi Vasänge
The retinoic acid and brain-derived neurotrophic factor differentiated SH-SY5Y cell line as a model for Alzheimer's disease-like tau phosphorylation.
Biochemical and biophysical research communications 2004;319(3):993-1000.
2004: Fiona Flood; Erik Sundström; Eva-Britt Samuelsson; Birgitta Wiehager; Ake Seiger; Janet A Johnston; Richard Frank Cowburn
Presenilin expression during induced differentiation of the human neuroblastoma SH-SY5Y cell line.
Neurochemistry international 2004;44(7):487-96.
2004: Annika Rickle; Nenad Bogdanovic; Inga Volkman; Bengt Winblad; Rivka Ravid; Richard Frank Cowburn
Akt activity in Alzheimer's disease and other neurodegenerative disorders.
Neuroreport 2004;15(6):955-9.
2004: Bogdan O Popescu; Angel Cedazo-Minguez; Eirikur Benedikz; Takeshi Nishimura; Bengt Winblad; Maria Ankarcrona; Richard Frank Cowburn
Gamma-secretase activity of presenilin 1 regulates acetylcholine muscarinic receptor-mediated signal transduction.
The Journal of biological chemistry 2004;279(8):6455-64.
2003: Angel Cedazo-Mínguez; Bogdan O Popescu; J M Blanco-Millán; Susanne Akterin; Jin-Jing Pei; Bengt Winblad; Richard Frank Cowburn
Apolipoprotein E and beta-amyloid (1-42) regulation of glycogen synthase kinase-3beta.
Journal of neurochemistry 2003;87(5):1152-64.
2003: Jin-Jing Pei; Cheng-Xin Gong; Wen-Lin An; Bengt Winblad; Richard Frank Cowburn; Inge Grundke-Iqbal; Khalid Iqbal
Okadaic-acid-induced inhibition of protein phosphatase 2A produces activation of mitogen-activated protein kinases ERK1/2, MEK1/2, and p70 S6, similar to that in Alzheimer's disease.
The American journal of pathology 2003;163(3):845-58.
2003: Angela García-Jiménez; Johan Fastbom; Thomas G Ohm; Richard Frank Cowburn
G-protein alpha-subunit levels in hippocampus and entorhinal cortex of brains staged for Alzheimer's disease neurofibrillary and amyloid pathologies.
Neuroreport 2003;14(11):1523-7.
2003: Wen-Lin An; Richard Frank Cowburn; Lin Li; Heiko Braak; Irina Alafuzoff; Khalid Iqbal; Inge Grundke-Iqbal; Bengt Winblad; Jin-Jing Pei
Up-regulation of phosphorylated/activated p70 S6 kinase and its relationship to neurofibrillary pathology in Alzheimer's disease.
The American journal of pathology 2003;163(2):591-607.
2003: Jin-Jing Pei; Sabiha Khatoon; Wen-Lin An; Maria Nordlinder; Toshihisa Tanaka; Heiko Braak; Ichiro Tsujio; Masatoshi Takeda; Irina Alafuzoff; Bengt Winblad; Richard Frank Cowburn; Inge Grundke-Iqbal; Khalid Iqbal
Role of protein kinase B in Alzheimer's neurofibrillary pathology.
Acta neuropathologica 2003;105(4):381-92.
2002: Jin-Jing Pei; Heiko Braak; Wen-Lin An; Bengt Winblad; Richard Frank Cowburn; Khalid Iqbal; Inge Grundke-Iqbal
Up-regulation of mitogen-activated protein kinases ERK1/2 and MEK1/2 is associated with the progression of neurofibrillary degeneration in Alzheimer's disease.
Brain research. Molecular brain research 2002;109(1-2):45-55.
2002: Jin-Jing Pei; Heiko Braak; Cheng-Xin Gong; Inge Grundke-Iqbal; Khalid Iqbal; Bengt Winblad; Richard Frank Cowburn
Up-regulation of cell division cycle (cdc) 2 kinase in neurons with early stage Alzheimer's disease neurofibrillary degeneration.
Acta neuropathologica 2002;104(4):369-76.
2002: Angel Cedazo-Minguez; Bogdan O Popescu; Maria Ankarcrona; Takeshi Nishimura; Richard Frank Cowburn
The presenilin 1 deltaE9 mutation gives enhanced basal phospholipase C activity and a resultant increase in intracellular calcium concentrations.
The Journal of biological chemistry 2002;277(39):36646-55.
2002: Ian F Smith; John P Boyle; Peter F T Vaughan; Hugh A Pearson; Richard Frank Cowburn; Chris Peers
Ca(2+) stores and capacitative Ca(2+) entry in human neuroblastoma (SH-SY5Y) cells expressing a familial Alzheimer's disease presenilin-1 mutation.
Brain research 2002;949(1-2):105-11.
2002: Leigh D Plant; John P Boyle; Natasha M Thomas; Nick J Hipkins; Eirikur Benedikz; Nigel M Hooper; Zaineb Henderson; Peter F T Vaughan; Chris Peers; Richard Frank Cowburn; Hugh A Pearson
Presenilin-1 mutations alter K+ currents in the human neuroblastoma cell line, SH-SY5Y.
Neuroreport 2002;13(12):1553-6.
2002: Angela García-Jiménez; Richard Frank Cowburn; Thomas G Ohm; H Lasn; Bengt Winblad; Nenad Bogdanovic; Johan Fastbom
Loss of stimulatory effect of guanosine triphosphate on [(35)S]GTPgammaS binding correlates with Alzheimer's disease neurofibrillary pathology in entorhinal cortex and CA1 hippocampal subfield.
Journal of neuroscience research 2002;67(3):388-98.
2001: Richard Killick; CC Pollard; Ayodeji A Asuni; Amritpal Mudher; Jill C Richardson; H T R Rupniak; Paul Sheppard; Ian Varndell; Jean-Pierre Brion; Allan Levey; O A Levy; M Vestling; Richard Frank Cowburn; Simon Lovestone; Brian H Anderton
Presenilin 1 independently regulates beta-catenin stability and transcriptional activity.
The Journal of biological chemistry 2001;276(51):48554-61.
2001: M Vestling; Birgitta Wiehager; H Tanii; Richard Frank Cowburn
Akt activity in presenilin 1 wild-type and mutation transfected human SH-SY5Y neuroblastoma cells after serum deprivation and high glucose stress.
Journal of neuroscience research 2001;66(3):448-56.
2001: Bogdan O Popescu; Angel Cedazo-Minguez; Laurentiu M Popescu; Bengt Winblad; Richard Frank Cowburn; Maria Ankarcrona
Caspase cleavage of exon 9 deleted presenilin-1 is an early event in apoptosis induced by calcium ionophore A 23187 in SH-SY5Y neuroblastoma cells.
Journal of neuroscience research 2001;66(1):122-34.
2001: Angel Cedazo-Mínguez; Richard Frank Cowburn
Apolipoprotein E isoform-specific disruption of phosphoinositide hydrolysis: protection by estrogen and glutathione.
FEBS letters 2001;504(1-2):45-9.
2001: Angel Cedazo-Mínguez; Richard Frank Cowburn
Apolipoprotein E: a major piece in the Alzheimer's disease puzzle.
Journal of cellular and molecular medicine 2001;5(3):254-66.
2001: Angel Cedazo-Mínguez; Birgitta Wiehager; Bengt Winblad; M Hüttinger; Richard Frank Cowburn
Effects of apolipoprotein E (apoE) isoforms, beta-amyloid (Abeta) and apoE/Abeta complexes on protein kinase C-alpha (PKC-alpha) translocation and amyloid precursor protein (APP) processing in human SH-SY5Y neuroblastoma cells and fibroblasts.
Neurochemistry international 2001;38(7):615-25.
2001: Angel Cedazo-Mínguez; M Hüttinger; Richard Frank Cowburn
Beta-VLDL protects against A beta(1-42) and apoE toxicity in human SH-SY5Y neuroblastoma cells.
Neuroreport 2001;12(2):201-6.
2001: Angel Cedazo-Mínguez; U Hamker; Volker Meske; R W Veh; R Hellweg; C Jacobi; Frank Albert; Richard Frank Cowburn; Thomas G Ohm
Regulation of apolipoprotein E secretion in rat primary hippocampal astrocyte cultures.
Neuroscience 2001;105(3):651-61.
2001: Cora O'Neill; Richard Frank Cowburn; WL Bonkale; Thomas G Ohm; Johan Fastbom; M Carmody; M Kelliher
Dysfunctional intracellular calcium homoeostasis: a central cause of neurodegeneration in Alzheimer's disease.
Biochemical Society symposium 2001;(67):177-94.
2001: Richard Frank Cowburn; Cora O'Neill; WL Bonkale; Thomas G Ohm; Johan Fastbom
Receptor-G-protein signalling in Alzheimer's disease.
Biochemical Society symposium 2001;(67):163-75.
2001: Thomas G Ohm; U Hamker; Angel Cedazo-Minguez; W Röckl; Hubert Scharnagl; W März; Richard Frank Cowburn; W Müller; Volker Meske
Apolipoprotein E and beta A4-amyloid: signals and effects.
Biochemical Society symposium 2001;(67):121-9.
2001: B Kostyszyn; Richard Frank Cowburn; Ake Seiger; Anders Kjaeldgaard; Erik Sundström
Expression of presenilin-1 and Notch-1 receptor in human embryonic CNS.
Neuroscience 2001;103(4):885-98.
2000: H Tanii; Maria Ankarcrona; Fiona Flood; Camilla Nilsberth; ND Mehta; Jordi Perez-Tur; Bengt Winblad; Eirikur Benedikz; Richard Frank Cowburn
Alzheimer's disease presenilin-1 exon 9 deletion and L250S mutations sensitize SH-SY5Y neuroblastoma cells to hyperosmotic stress-induced apoptosis.
Neuroscience 2000;95(2):593-601.
1999: Angela García-Jiménez; Richard Frank Cowburn; Thomas G Ohm; Nenad Bogdanovic; Bengt Winblad; Johan Fastbom
Quantitative autoradiography of [3H]forskolin binding sites in post-mortem brain staged for Alzheimer's disease neurofibrillary changes and amyloid deposits.
Brain research 1999;850(1-2):104-17.
1999: Angel Cedazo-Minguez; L Bonecchi; Bengt Winblad; C Post; E H Wong; Richard Frank Cowburn; L Benatti
Nicergoline stimulates protein kinase C mediated alpha-secretase processing of the amyloid precursor protein in cultured human neuroblastoma SH-SY5Y cells.
Neurochemistry international 1999;35(4):307-15.
1999: Jin-Jing Pei; Eva Braak; Heiko Braak; Inge Grundke-Iqbal; Khalid Iqbal; Bengt Winblad; Richard Frank Cowburn
Distribution of active glycogen synthase kinase 3beta (GSK-3beta) in brains staged for Alzheimer disease neurofibrillary changes.
Journal of neuropathology and experimental neurology 1999;58(9):1010-9.
1999: A Garcia-Jiménez; Richard Frank Cowburn; Bengt Winblad; Johan Fastbom
Inhibition of [3H]forskolin binding by Gpp[NH]p may reflect adenylate cyclase coupling to Gi.
Neuroreport 1999;10(11):2423-7.
1999: M Vestling; Angel Cedazo-Mínguez; Abdu Adem; Birgitta Wiehager; Marco Racchi; Lars Lannfelt; Richard Frank Cowburn
Protein kinase C and amyloid precursor protein processing in skin fibroblasts from sporadic and familial Alzheimer's disease cases.
Biochimica et biophysica acta 1999;1453(3):341-50.
1999: Marco Racchi; Janet A Johnston; Fiona Flood; Richard Frank Cowburn; Stefano Govoni
Amyloid precursor protein metabolism in fibroblasts from individuals with one, two or three copies of the amyloid precursor protein (APP) gene.
The Biochemical journal 1999;338 ( Pt 3)():777-82.
1999: WL Bonkale; Richard Frank Cowburn; Thomas G Ohm; Nenad Bogdanovic; Johan Fastbom
A quantitative autoradiographic study of [3H]cAMP binding to cytosolic and particulate protein kinase A in post-mortem brain staged for Alzheimer's disease neurofibrillary changes and amyloid deposits.
Brain research 1999;818(2):383-96.
1999: M Kelliher; Johan Fastbom; Richard Frank Cowburn; WL Bonkale; Thomas G Ohm; Rivka Ravid; V Sorrentino; Cora O'Neill
Alterations in the ryanodine receptor calcium release channel correlate with Alzheimer's disease neurofibrillary and beta-amyloid pathologies.
Neuroscience 1999;92(2):499-513.
1998: Angela García-Jiménez; Richard Frank Cowburn; B Einblad; Johan Fastbom
Inhibition of [3H]forskolin binding by Gpp[NH]p may reflect adenylyl cyclase coupling to Gi.
Neuroreport 1998;9(14):3329-33.
1998: Gary Gibson; Hui Zhang; KF Sheu; N Bogdanovich; JG Lindsay; Lars Lannfelt; M Vestling; Richard Frank Cowburn
Alpha-ketoglutarate dehydrogenase in Alzheimer brains bearing the APP670/671 mutation.
Annals of neurology 1998;44(4):676-81.
1998: Jin-Jing Pei; Inge Grundke-Iqbal; Khalid Iqbal; Nenad Bogdanovic; Bengt Winblad; Richard Frank Cowburn
Accumulation of cyclin-dependent kinase 5 (cdk5) in neurons with early stages of Alzheimer's disease neurofibrillary degeneration.
Brain research 1998;797(2):267-77.
1998: T Kurumatani; Johan Fastbom; WL Bonkale; Nenad Bogdanovic; Bengt Winblad; Thomas G Ohm; Richard Frank Cowburn
Loss of inositol 1,4,5-trisphosphate receptor sites and decreased PKC levels correlate with staging of Alzheimer's disease neurofibrillary pathology.
Brain research 1998;796(1-2):209-21.
1998: Jin-Jing Pei; Cheng-Xin Gong; Khalid Iqbal; Inge Grundke-Iqbal; Q L Wu; Bengt Winblad; Richard Frank Cowburn
Subcellular distribution of protein phosphatases and abnormally phosphorylated tau in the temporal cortex from Alzheimer's disease and control brains.
Journal of neural transmission (Vienna, Austria : 1996) 1998;105(1):69-83.
1997: Janet A Johnston; Lars Lannfelt; Birgitta Wiehager; C O'Neill; Richard Frank Cowburn
Amyloid precursor protein heat shock response in lymphoblastoid cell lines bearing presenilin-1 mutations.
Biochimica et biophysica acta 1997;1362(2-3):183-92.
1997: Richard Frank Cowburn; Birgitta Wiehager; E Trief; M Li-Li; Erik Sundström
Effects of beta-amyloid-(25-35) peptides on radioligand binding to excitatory amino acid receptors and voltage-dependent calcium channels: evidence for a selective affinity for the glutamate and glycine recognition sites of the NMDA receptor.
Neurochemical research 1997;22(12):1437-42.
1997: Gary Gibson; M Vestling; Hui Zhang; S Szolosi; D Alkon; Lars Lannfelt; Sam Gandy; Richard Frank Cowburn
Abnormalities in Alzheimer's disease fibroblasts bearing the APP670/671 mutation.
Neurobiology of aging 1997;18(6):573-80.
1997: Fiona Flood; Richard Frank Cowburn; Janet A Johnston
Presenilin-1, amyloid precursor protein and amyloid precursor-like protein 2 mRNA levels in human superior frontal cortex during aging.
Neuroscience letters 1997;235(1-2):17-20.
1997: Charlotte Forsell; S Froelich; Karin Axelman; M Vestling; Richard Frank Cowburn; Lena Lilius; J A Johnston; Benita Engvall; Kurt Johansson; A Dahlkild; M Ingelson; Peter St George-Hyslop; Lars Lannfelt
A novel pathogenic mutation (Leu262Phe) found in the presenilin 1 gene in early-onset Alzheimer's disease.
Neuroscience letters 1997;234(1):3-6.
1997: C Shanahan; Gary Gibson; Richard Frank Cowburn; Janet A Johnston; Birgitta Wiehager; Lars Lannfelt; C O'Neill
G protein subunit levels in fibroblasts from familial Alzheimer's disease patients: lower levels of high molecular weight Gs alpha isoform in patients with decreased beta-adrenergic receptor stimulated cAMP formation.
Neuroscience letters 1997;232(1):33-6.
1997: Angela García-Jiménez; Richard Frank Cowburn; Bengt Winblad; Johan Fastbom
Autoradiographic characterisation of [35S]GTP gamma S binding sites in rat brain.
Neurochemical research 1997;22(8):1055-63.
1997: WL Bonkale; Richard Frank Cowburn; Bengt Winblad; Johan Fastbom
Autoradiographic characterization of [3H]cGMP binding sites in the rat brain.
Brain research 1997;763(1):1-13.
1997: M Lindh; M Blomberg; M Jensen; Hans Basun; Lars Lannfelt; Benita Engvall; H Scharnagel; W März; Lars-Olof Wahlund; Richard Frank Cowburn
Cerebrospinal fluid apolipoprotein E (apoE) levels in Alzheimer's disease patients are increased at follow up and show a correlation with levels of tau protein.
Neuroscience letters 1997;229(2):85-8.
1997: M Vestling; Abdu Adem; Marco Racchi; Gary Gibson; Lars Lannfelt; Richard Frank Cowburn
Differential regulation of adenylyl cyclase in fibroblasts from sporadic and familial Alzheimer's disease cases with PS1 and APP mutations.
Neuroreport 1997;8(8):2031-5.
1997: A Garlind; Janet A Johnston; A Algotsson; Bengt Winblad; Richard Frank Cowburn
Decreased beta-adrenoceptor-stimulated adenylyl cyclase activity in lymphocytes from Alzheimer's disease patients.
Neuroscience letters 1997;226(1):37-40.
1997: Jin-Jing Pei; Inge Grundke-Iqbal; Khalid Iqbal; Nenad Bogdanovic; Bengt Winblad; Richard Frank Cowburn
Elevated protein levels of protein phosphatases PP-2A and PP-2B in astrocytes of Alzheimer's disease temporal cortex.
Journal of neural transmission (Vienna, Austria : 1996) 1997;104(11-12):1329-38.
1997: T Kurumatani; Richard Frank Cowburn; Nenad Bogdanovic; Bengt Winblad; Johan Fastbom
Autoradiographic characterization of [3H]inositol (1,4,5) trisphosphate and [3H]inositol (1,3,4,5) tetrakisphosphate binding sites in human brain.
Journal of neural transmission (Vienna, Austria : 1996) 1997;104(2-3):175-89.
1997: C J Fowler; Richard Frank Cowburn; James A Joseph
Alzheimer's, ageing and amyloid: an absurd allegory?
Gerontology 1997;43(1-2):132-42.
1996: Janet A Johnston; S Norgren; Rivka Ravid; Wilma Wasco; Bengt Winblad; Lars Lannfelt; Richard Frank Cowburn
Quantification of APP and APLP2 mRNA in APOE genotyped Alzheimer's disease brains.
Brain research. Molecular brain research 1996;43(1-2):85-95.
1996: Janet A Johnston; S Norgren; G Annerén; Richard Frank Cowburn; Lars Lannfelt
A new quantitative solution hybridisation-RNase protection assay for APP and APLP2 mRNA.
Brain research. Molecular brain research 1996;43(1-2):77-84.
1996: Richard Frank Cowburn; Christopher J Fowler; C O'Neill
Neurotransmitter receptor/G-protein mediated signal transduction in Alzheimer's disease brain.
Neurodegeneration : a journal for neurodegenerative disorders, neuroprotection, and neuroregeneration 1996;5(4):483-8.
1996: WL Bonkale; Johan Fastbom; Birgitta Wiehager; Rivka Ravid; Bengt Winblad; Richard Frank Cowburn
Impaired G-protein-stimulated adenylyl cyclase activity in Alzheimer's disease brain is not accompanied by reduced cyclic-AMP-dependent protein kinase A activity.
Brain research 1996;737(1-2):155-61.
1996: Janet A Johnston; S Froelich; Lars Lannfelt; Richard Frank Cowburn
Quantification of presenilin-1 mRNA in Alzheimer's disease brains.
FEBS letters 1996;394(3):279-84.
1996: Christopher J Fowler; A Garlind; C O'Neill; Richard Frank Cowburn
Receptor-effector coupling dysfunctions in Alzheimer's disease.
Annals of the New York Academy of Sciences 1996;786():294-304.
1996: LS Haug; Anne Carine Ostvold; Richard Frank Cowburn; A Garlind; Bengt Winblad; N Bogdanovich; S Ivar Walaas
Decreased inositol (1,4,5)-trisphosphate receptor levels in Alzheimer's disease cerebral cortex: selectivity of changes and possible correlation to pathological severity.
Neurodegeneration : a journal for neurodegenerative disorders, neuroprotection, and neuroregeneration 1996;5(2):169-76.
1996: Richard Frank Cowburn; Birgitta Wiehager; Rivka Ravid; Bengt Winblad
Acetylcholine muscarinic M2 receptor stimulated [35S]GTP gamma S binding shows regional selective changes in Alzheimer's disease postmortem brain.
Neurodegeneration : a journal for neurodegenerative disorders, neuroprotection, and neuroregeneration 1996;5(1):19-26.
1996: Kaj Blennow; Richard Frank Cowburn
The neurochemistry of Alzheimer's disease.
Acta neurologica Scandinavica. Supplementum 1996;168():77-86.
1996: Richard Frank Cowburn; Christopher J Fowler; C O'Neill
Neurotransmitters, signal transduction and second-messengers in Alzheimer's disease.
Acta neurologica Scandinavica. Supplementum 1996;165():25-32.
1995: Richard Frank Cowburn; C O'Neill; C J Fowler
Membrane alterations in Alzheimer's disease and aging.
Trends in neurosciences 1995;18(11):483-4.
1995: Christopher J Fowler; Richard Frank Cowburn; A Garlind; Bengt Winblad; C O'Neill
Disturbances in signal transduction mechanisms in Alzheimer's disease.
Molecular and cellular biochemistry 1995;149-150():287-92.
1995: A Garlind; Richard Frank Cowburn; Charlotte Forsell; Rivka Ravid; Bengt Winblad; Christopher J Fowler
Diminished [3H]inositol(1,4,5)P3 but not [3H]inositol(1,3,4,5)P4 binding in Alzheimer's disease brain.
Brain research 1995;681(1-2):160-6.
1995: Richard Frank Cowburn; Birgitta Wiehager; Erik Sundström
beta-Amyloid peptides enhance binding of the calcium mobilising second messengers, inositol(1,4,5)trisphosphate and inositol-(1,3,4,5)tetrakisphosphate to their receptor sites in rat cortical membranes.
Neuroscience letters 1995;191(1-2):31-4.
1995: WL Bonkale; Bengt Winblad; Rivka Ravid; Richard Frank Cowburn
Reduced nitric oxide responsive soluble guanylyl cyclase activity in the superior temporal cortex of patients with Alzheimer's disease.
Neuroscience letters 1995;187(1):5-8.
1995: A Hérnandez-Hérnandez; A Adem; Rivka Ravid; Richard Frank Cowburn
Preservation of acetylcholine muscarinic M2 receptor G-protein interactions in the neocortex of patients with Alzheimer's disease.
Neuroscience letters 1995;186(1):57-60.
1995: A Garlind; Richard Frank Cowburn; Birgitta Wiehager; Rivka Ravid; Bengt Winblad; Christopher J Fowler
Preservation of kappa 1 opioid receptor recognition site density and regulation by G-proteins in the temporal cortex of patients with Alzheimer's disease.
Neuroscience letters 1995;185(2):131-4.
1995: A Garlind; Richard Frank Cowburn; Christopher J Fowler
Characteristics of [3H]inositol(1,3,4,5)tetrakisphosphate recognition sites in human cerebellar membranes.
Journal of neural transmission. General section 1995;100(2):101-9.
1995: M Vestling; Richard Frank Cowburn; N Venizelos; Lars Lannfelt; Bengt Winblad; Abdu Adem
Characterization of muscarinic acetylcholine receptors in cultured adult skin fibroblasts: effects of the Swedish Alzheimer's disease APP 670/671 mutation on binding levels.
Journal of neural transmission. Parkinson's disease and dementia section 1995;10(1):1-10.
1994: Janet A Johnston; Richard Frank Cowburn; S Norgren; Birgitta Wiehager; N Venizelos; Bengt Winblad; C Vigo-Pelfrey; Dale Schenk; Lars Lannfelt; C O'Neill
Increased beta-amyloid release and levels of amyloid precursor protein (APP) in fibroblast cell lines from family members with the Swedish Alzheimer's disease APP670/671 mutation.
FEBS letters 1994;354(3):274-8.
1994: J Johnston; C O'Neill; Lars Lannfelt; Bengt Winblad; Richard Frank Cowburn
The significance of the Swedish APP670/671 mutation for the development of Alzheimer's disease amyloidosis.
Neurochemistry international 1994;25(1):73-80.
1994: C O'Neill; Birgitta Wiehager; Christopher J Fowler; Rivka Ravid; Bengt Winblad; Richard Frank Cowburn
Regionally selective alterations in G protein subunit levels in the Alzheimer's disease brain.
Brain research 1994;636(2):193-201.
1994: Lars Lannfelt; J Johnston; N Bogdanovich; Richard Frank Cowburn
Amyloid precursor protein gene mutation at codon 670/671 in familial Alzheimer's disease in Sweden.
Biochemical Society transactions 1994;22(1):176-9.
1994: C O'Neill; Christopher J Fowler; Bengt Winblad; Richard Frank Cowburn
G-protein coupled signal transduction systems in the Alzheimer's disease brain.
Biochemical Society transactions 1994;22(1):167-71.
1994: Richard Frank Cowburn; E Messamore; M L Li; Bengt Winblad; E Sundström
beta-Amyloid related peptides exert differential effects on [3H]MK-801 binding to rat cortical membranes.
Neuroreport 1994;5(4):405-8.
1994: Richard Frank Cowburn; J O Marcusson; A Eriksson; Birgitta Wiehager; C O'Neill
Adenylyl cyclase activity and G-protein subunit levels in postmortem frontal cortex of suicide victims.
Brain research 1994;633(1-2):297-304.
1994: A Garlind; Richard Frank Cowburn; Christopher J Fowler
Characterization of [3H]inositol 1,4,5-trisphosphate binding sites in human temporal cortical and cerebellar membranes.
Neurochemistry international 1994;24(1):73-80.
1993: J Johnston; Lena Lilius; Karin Axelman; Richard Frank Cowburn; K Johansson; Matti Viitanen; Bengt Winblad; Lars Lannfelt
Sequencing of exons 16 and 17 of the beta-amyloid precursor protein gene fails to identify new mutations in Swedish Alzheimer's disease patients.
Human molecular genetics 1993;2(7):1045-6.
1993: Richard Frank Cowburn; M Vestling; Christopher J Fowler; Rivka Ravid; Bengt Winblad; C O'Neill
Disrupted beta 1-adrenoceptor-G protein coupling in the temporal cortex of patients with Alzheimer's disease.
Neuroscience letters 1993;155(2):163-6.
1993: Bengt Winblad; E Messamore; C O'Neill; Richard Frank Cowburn
Biochemical pathology and treatment strategies in Alzheimer's disease: emphasis on the cholinergic system.
Acta neurologica Scandinavica. Supplementum 1993;149():4-6.
1992: Richard Frank Cowburn; C O'Neill; Rivka Ravid; Bengt Winblad; Christopher J Fowler
Preservation of Gi-protein inhibited adenylyl cyclase activity in the brains of patients with Alzheimer's disease.
Neuroscience letters 1992;141(1):16-20.
1992: Richard Frank Cowburn; C O'Neill; Rivka Ravid; Irina Alafuzoff; Bengt Winblad; Christopher J Fowler
Adenylyl cyclase activity in postmortem human brain: evidence of altered G protein mediation in Alzheimer's disease.
Journal of neurochemistry 1992;58(4):1409-19.
1992: R H Porter; Richard Frank Cowburn; I Alasuzoff; R S Briggs; Peter J Roberts
Heterogeneity of NMDA receptors labelled with [3H]3-((+-)-2-carboxypiperazin-4-yl) propyl-1-phosphonic acid ([3H]CPP): receptor status in Alzheimer's disease brains.
European journal of pharmacology 1992;225(3):195-201.
1992: Christopher J Fowler; Richard Frank Cowburn; C O'Neill
Brain signal transduction disturbances in neurodegenerative disorders.
Cellular signalling 1992;4(1):1-9.
1992: Christopher J Fowler; C O'Neill; Bengt Winblad; Richard Frank Cowburn
Neurotransmitter, receptor and signal transduction disturbances in Alzheimer's disease.
Acta neurologica Scandinavica. Supplementum 1992;139():59-62.
1992: A Garlind; Christopher J Fowler; Irina Alafuzoff; Bengt Winblad; Richard Frank Cowburn
Neurotransmitter-mediated inhibition of post-mortem human brain adenylyl cyclase.
Journal of neural transmission. General section 1992;87(2):113-24.
1992: Belén Arranz; Richard Frank Cowburn; A Eriksson; M Vestling; Jan Marcusson
Gamma-aminobutyric acid-B (GABAB) binding sites in postmortem suicide brains.
Neuropsychobiology 1992;26(1-2):33-6.
1991: C O'Neill; Richard Frank Cowburn; Birgitta Wiehager; Irina Alafuzoff; Bengt Winblad; Christopher J Fowler
Preservation of 5-hydroxytryptamine1A receptor-G protein interactions in the cerebral cortex of patients with Alzheimer's disease.
Neuroscience letters 1991;133(1):15-9.
1991: C O'Neill; Christopher J Fowler; Birgitta Wiehager; Richard Frank Cowburn; Irina Alafuzoff; Bengt Winblad
Coupling of human brain cerebral cortical alpha 2-adrenoceptors to GTP-binding proteins in Alzheimer's disease.
Brain research 1991;563(1-2):39-43.
1991: L Bergström; A Garlind; L Nilsson; Irina Alafuzoff; Christopher J Fowler; Bengt Winblad; Richard Frank Cowburn
Regional distribution of somatostatin receptor binding and modulation of adenylyl cyclase activity in Alzheimer's disease brain.
Journal of the neurological sciences 1991;105(2):225-33.
1991: Richard Frank Cowburn; Christopher J Fowler; A Garlind; Irina Alafuzoff; L Nilsson; Bengt Winblad; L Bergström
Somatostatin receptors and the modulation of adenylyl cyclase activity in Alzheimer's disease.
Journal of neurology, neurosurgery, and psychiatry 1991;54(8):748-9.
1991: Richard Frank Cowburn; D Young; Johan Luthman
Enhanced adenylate cyclase activity in neonatally dopamine lesioned rats is related to increased Gs-protein coupling.
European journal of pharmacology 1991;207(3):271-4.
1991: Richard Frank Cowburn; A Garlind; C O'Neill; Irina Alafuzoff; Bengt Winblad; Christopher J Fowler
Characterization and regional distribution of adenylyl cyclase activity from human brain.
Neurochemistry international 1991;18(3):389-98.
1990: Richard Frank Cowburn; John Hardy; Peter J Roberts
Glutamatergic neurotransmission in Alzheimer's disease.
Biochemical Society transactions 1990;18(3):390-2.
1990: Christopher J Fowler; C O'Neill; A Garlind; Richard Frank Cowburn
Alzheimer's disease: is there a problem beyond recognition?
Trends in pharmacological sciences 1990;11(5):183-4.
1990: Gunnar Tiger; P E Björklund; Richard Frank Cowburn; A Garlind; C O'Neill; Birgitta Wiehager; Christopher J Fowler
Effect of monovalent ions upon G proteins coupling muscarinic receptors to phosphoinositide hydrolysis in the rat cerebral cortex.
European journal of pharmacology 1990;188(1):51-62.
1990: Hans Basun; L G Forssell; Ove Almkvist; Richard Frank Cowburn; R Eklöf; Bengt Winblad; L Wetterberg
Amino acid concentrations in cerebrospinal fluid and plasma in Alzheimer's disease and healthy control subjects.
Journal of neural transmission. Parkinson's disease and dementia section 1990;2(4):295-304.
1990: J Luthman; Eva Lindqvist; D Young; Richard Frank Cowburn
Neonatal dopamine lesion in the rat results in enhanced adenylate cyclase activity without altering dopamine receptor binding or dopamine- and adenosine 3':5'-monophosphate-regulated phosphoprotein (DARPP-32) immunoreactivity.
Experimental brain research. Experimentelle Hirnforschung. Expérimentation cérébrale 1990;83(1):85-95.
1989: P R Dodd; W E Watson; M M Morrison; Graham A R Johnston; E D Bird; Richard Frank Cowburn; John Hardy
Uptake of gamma-aminobutyric acid and L-glutamic acid by synaptosomes from postmortem human cerebral cortex: multiple sites, sodium dependence and effect of tissue preparation.
Brain research 1989;490(2):320-31.
1989: Gunnar Tiger; P E Björklund; Richard Frank Cowburn; Christopher J Fowler
Enhancement by potassium of carbachol-stimulated inositol phospholipid breakdown in rat cerebral cortical miniprisms: comparison with other depolarising agents.
Journal of neurochemistry 1989;52(6):1843-53.
1989: J Willoughby; Richard Frank Cowburn; John Hardy; Vivette Glover; Merton Sandler
1-Methyl-4-phenylpyridinium uptake by human and rat striatal synaptosomes.
Journal of neurochemistry 1989;52(2):627-31.
1989: Richard Frank Cowburn; John Hardy; R S Briggs; Peter J Roberts
Characterisation, density, and distribution of kainate receptors in normal and Alzheimer's diseased human brain.
Journal of neurochemistry 1989;52(1):140-7.
1988: Richard Frank Cowburn; John Hardy; P Roberts; R Briggs
Regional distribution of pre- and postsynaptic glutamatergic function in Alzheimer's disease.
Brain research 1988;452(1-2):403-7.
1988: Richard Frank Cowburn; John Hardy; Peter J Roberts
Characterisation of Na+-independent L-[3H]glutamate binding sites in human temporal cortex.
Journal of neurochemistry 1988;50(6):1872-8.
1988: P R Dodd; J W Hambley; Richard Frank Cowburn; John Hardy
A comparison of methodologies for the study of functional transmitter neurochemistry in human brain.
Journal of neurochemistry 1988;50(5):1333-45.
1988: I O'Connor; Richard Frank Cowburn; John Hardy; C J Fowler
Dopamine and apomorphine do not modulate the uptake of [3H]D-aspartate in the rat striatum in-vitro.
The Journal of pharmacy and pharmacology 1988;40(4):307-8.
1988: Richard Frank Cowburn; John Hardy; P Roberts; R Briggs
Presynaptic and postsynaptic glutamatergic function in Alzheimer's disease.
Neuroscience letters 1988;86(1):109-13.
1987: John Hardy; Richard Frank Cowburn; A Barton; G Reynolds; P Dodd; P Wester; A M O'Carroll; E Lofdahl; Bengt Winblad
A disorder of cortical GABAergic innervation in Alzheimer's disease.
Neuroscience letters 1987;73(2):192-6.
1987: John Hardy; Richard Frank Cowburn; A Barton; G Reynolds; E Lofdahl; A M O'Carroll; P Wester; Bengt Winblad
Region-specific loss of glutamate innervation in Alzheimer's disease.
Neuroscience letters 1987;73(1):77-80.
1987: Richard Frank Cowburn; P R Dodd; John Hardy; G A Johnston
A comparison of high affinity synaptosomal uptake of d-aspartate in rat and human brain.
Neurochemistry international 1987;10(3):339-46.