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Cezmi A. Akdis

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A Wesley Burks; Moises A Calderon; Thomas Casale; Linda Cox; Pascal Demoly; Marek Jutel; Harold Nelson; Cezmi A. Akdis
Update on allergy immunotherapy: American Academy of Allergy, Asthma & Immunology/European Academy of Allergy and Clinical Immunology/PRACTALL consensus report.
Cansin Sackesen; Ozge U Soyer; B Stanic; W van de Veen; J Zumkehr; Mübeccel Akdis; S S Alkan; I Gursel; O Kalaycı; B Ruckert; Cezmi A. Akdis
Suppression of B-cell activation and IgE, IgA, IgG1 and IgG4 production by mammalian telomeric oligonucleotides.
Willem van de Veen; Marcin Wawrzyniak; Görkem Yaman; Cezmi A. Akdis; Deniz G Akdis; Beate Rückert; Stefan Söllner; Barbara Stanic; Mübeccel Akdis
IgG4 production is confined to human IL-10-producing regulatory B cells that suppress antigen-specific immune responses.

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All Publications

2013: A Wesley Burks; Moises A Calderon; Thomas Casale; Linda Cox; Pascal Demoly; Marek Jutel; Harold Nelson; Cezmi A. Akdis
Update on allergy immunotherapy: American Academy of Allergy, Asthma & Immunology/European Academy of Allergy and Clinical Immunology/PRACTALL consensus report.
The Journal of allergy and clinical immunology 2013;131(5):1288-1296.e3.
2013: Cansin Sackesen; Ozge U Soyer; B Stanic; W van de Veen; J Zumkehr; Mübeccel Akdis; S S Alkan; I Gursel; O Kalaycı; B Ruckert; Cezmi A. Akdis
Suppression of B-cell activation and IgE, IgA, IgG1 and IgG4 production by mammalian telomeric oligonucleotides.
Allergy 2013;68(5):593-603.
2013: Willem van de Veen; Marcin Wawrzyniak; Görkem Yaman; Cezmi A. Akdis; Deniz G Akdis; Beate Rückert; Stefan Söllner; Barbara Stanic; Mübeccel Akdis
IgG4 production is confined to human IL-10-producing regulatory B cells that suppress antigen-specific immune responses.
The Journal of allergy and clinical immunology 2013;131(4):1204-12.
2013: Kerstin Tiringer; Angela Treis; Cezmi A. Akdis; Reto Crameri; Eleonora Dehlink; Gerd Döring; Thomas Frischer; Petra Fucik; Mia Gona; Saskia Gruber; Friedrich Horak; Marcus Hörmann; Peter Jaksch; Andreas Jung; Walter Klepetko; Edith Nachbaur; Sabine Renner; Mascha K Rochat; Andreas Spittler; Zsolt Szépfalusi; Thomas Eiwegger
A Th17- and Th2-skewed cytokine profile in cystic fibrosis lungs represents a potential risk factor for Pseudomonas aeruginosa infection.
American journal of respiratory and critical care medicine 2013;187(6):621-9.
2013: Umut Can Kücüksezer; Andreas Nandy; Oscar Palomares; Tuomo Puhakka; Beate Rückert; Günnur Deniz; Heinz B Fahrner; Bilun Gemicioğlu; Tuomas Jartti; Andreas Jung; Cezmi A. Akdis; Mübeccel Akdis
Triggering of specific Toll-like receptors and proinflammatory cytokines breaks allergen-specific T-cell tolerance in human tonsils and peripheral blood.
The Journal of allergy and clinical immunology 2013;131(3):875-85.
2013: O U Soyer; Mübeccel Akdis; H Behrendt; Reto Crameri; Roger Lauener; Johannes Ring; Cezmi A. Akdis
Mechanisms of peripheral tolerance to allergens.
Allergy 2013;68(2):161-70.
2013: Norbert Meyer; Cezmi A. Akdis
Vascular endothelial growth factor as a key inducer of angiogenesis in the asthmatic airways.
Current allergy and asthma reports 2013;13(1):1-9.
2013: Tari Haahtela; Stephen Holgate; Ruby Pawankar; Jay Portnoy; Leena von Hertzen; Cezmi A. Akdis; Suwat Benjaponpitak; Luis Caraballo; Jeffrey Demain
The biodiversity hypothesis and allergic disease: world allergy organization position statement.
The World Allergy Organization journal 2013;6(1):3.
2012: Michael B Soyka; Angela Treis; Kerstin Wanke; Paulina Wawrzyniak; Thomas Eiwegger; David Holzmann; Jeannette I Kast; Cezmi A. Akdis
Defective epithelial barrier in chronic rhinosinusitis: the regulation of tight junctions by IFN-γ and IL-4.
The Journal of allergy and clinical immunology 2012;130(5):1087-1096.e10.
2012: Thomas Eiwegger; Saskia Gruber; Zsolt Szépfalusi; Cezmi A. Akdis
Novel developments in the mechanisms of immune tolerance to allergens.
Human vaccines & immunotherapeutics 2012;8(10):1485-91.
2012: Mark Ballow; Thomas B Casale; Cezmi A. Akdis; Zuhair Ballas; Andrew J Wardlaw; Sally E Wenzel; Jan Lötvall
Immune response modifiers in the treatment of asthma: A PRACTALL document of the American Academy of Allergy, Asthma & Immunology and the European Academy of Allergy and Clinical Immunology.
The Journal of allergy and clinical immunology 2012;130(2):311-24.
2012: Jeannette I Kast; Külli Kingo; Ana Rebane; Michael B Soyka; Kerstin Wanke; Paulina Wawrzyniak; Deniz Akdis; Cezmi A. Akdis
The broad spectrum of interepithelial junctions in skin and lung.
The Journal of allergy and clinical immunology 2012;130(2):544-7.e4.
2012: N G Papadopoulos; H Paramesh; R Pawankar; P Pohunek; J Pongracic; D Price; G Roberts; C Robertson; N Rosario; L J Rossenwasser; P D Sly; R Stein; S Stick; S Szefler; L M Taussig; E Valovirta; H P van Bever; P Vichyanond; D Wallace; E Weinberg; G Wennergren; J Wildhaber; G Wong; H Zar; N Aït-Khaled; Cezmi A. Akdis; H Arakawa; L B Bacharier; E Baraldi; A Boner; W Burks; K-H Carlsen; T B Casale; J A Castro-Rodriguez; Y Z Chen; A Custovic; J de Blic; J C de Jongste; Y M El-Gamal; M L Everard; T Frischer; M Geller; J Gereda; J Gern; D Y Goh; T W Guilbert; G Hedlin; P W Heymann; S J Hong; E M Hossny; J L Huang; D J Jackson; O Kalayci; S Kling; P Kuna; S Lau; P Le Souef; D K Ledford; S I Lee; R Lemanske; A H Liu; R F Lockey; K Lødrup-Carlsen; J Lötvall; M Mäkelä; A Morikawa; A Nieto; R S Zeiger
International consensus on (ICON) pediatric asthma.
Allergy 2012;67(8):976-97.
2012: I Agache; Cezmi A. Akdis; Marek Jutel; J C Virchow
Untangling asthma phenotypes and endotypes.
Allergy 2012;67(7):835-46.
2012: Mübeccel Akdis; Oscar Palomares; Willem van de Veen; Marloes van Splunter; Cezmi A. Akdis
TH17 and TH22 cells: a confusion of antimicrobial response with tissue inflammation versus protection.
The Journal of allergy and clinical immunology 2012;129(6):1438-49; quiz1450-1.
2012: B Samoliński; D Sienkiewicz; Agnieszka Tomaszewska; E Von Mutius; D Willman; A Włodarczyk; O Yusuf; T Zuberbier; Cezmi A. Akdis; J M Anto; A Z Bialoszewski; J Bousquet; P G Burney; A Bush; A Czupryniak; R Dahl; B Flood; A Fronczak; G Galea; M Jutel; M L Kowalski; P Kuna; S Palkonen; N Papadopoulos; F Raciborski
Prevention and control of childhood asthma and allergy in the EU from the public health point of view: Polish Presidency of the European Union.
Allergy 2012;67(6):726-31.
2012: M B Soyka; A Treis; S Zhang; Cezmi A. Akdis; Thomas Eiwegger; David Holzmann; Günter Menz; N Meyer
Regulation and expression of IL-32 in chronic rhinosinusitis.
Allergy 2012;67(6):790-8.
2012: Cemalettin Bekpen; Priscillia Siswara; Ibrahim Tastekin; Cezmi A. Akdis; Evan E Eichler
Primate segmental duplication creates novel promoters for the LRRC37 gene family within the 17q21.31 inversion polymorphism region.
Genome research 2012;22(6):1050-8.
2012: Patrycja Konieczna; Eamonn M M Quigley; Fergus Shanahan; Cezmi A. Akdis; Liam O'Mahony
Portrait of an immunoregulatory Bifidobacterium.
Gut microbes 2012;3(3):261-6.
2012: Cezmi A. Akdis
Therapies for allergic inflammation: refining strategies to induce tolerance.
Nature medicine 2012;18(5):736-49.
2012: Gabriela Senti; Ozge Soyer; Martin Steiner; Christine Tivig; Marianne van Hage; Anna Zaleska; Daniela Kuster; Julia M Martinez-Gomez; Horst Rose; Cezmi A. Akdis; Mübeccel Akdis; Reto Crameri; Nicole Graf; Hans Grönlund; Ludwig A Hothorn; Pål Johansen; Thomas M Kündig
Intralymphatic immunotherapy for cat allergy induces tolerance after only 3 injections.
The Journal of allergy and clinical immunology 2012;129(5):1290-6.
2012: Ana Rebane; Jaak Vilo; Stephan Weidinger; Maya Zimmermann; Alar Aab; Kristi Abram; Mübeccel Akdis; Hansjörg Baurecht; Regina Fölster-Holst; Andre Franke; Thomas Illig; Mati Karelson; Lajos Kemeny; Külli Kingo; Andrea Koreck; Tauno Metsalu; Norbert Meyer; Nikoletta Nagy; Natalija Novak; Maire Pihlap; Cezmi A. Akdis
Mechanisms of IFN-γ-induced apoptosis of human skin keratinocytes in patients with atopic dermatitis.
The Journal of allergy and clinical immunology 2012;129(5):1297-306.
2012: Michael B Soyka; David Holzmann; Cezmi A. Akdis
Regulatory cells in allergen-specific immunotherapy.
Immunotherapy 2012;4(4):389-96.
2012: Jan Lötvall; Nikolaos G Papadopoulos; Ruby Pawankar; Lanny J Rosenwasser; Dana V Wallace; Richard W Weber; A Wesley Burks; Cezmi A. Akdis; Thomas B Casale; Stanley M Fineman; Dennis K Ledford; Richard F Lockey
We call for iCAALL: International Collaboration for Asthma, Allergy and Immunology.
Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology 2012;108(4):215-6.
2012: Mübeccel Akdis; Cezmi A. Akdis
IgE class switching and cellular memory.
Nature immunology 2012;13(4):312-4.
2012: Jan Lötvall; N G Papadopoulos; Ruby Pawankar; Lanny J Rosenwasser; D V Wallace; R W Weber; A Wesley Burks; Cezmi A. Akdis; T B Casale; Stanley M Fineman; D K Ledford; R F Lockey
We call for iCAALL: International Collaboration in Asthma, Allergy and Immunology.
Allergy 2012;67(4):449-50.
2012: Jan Lötvall; Nikolaos G Papadopoulos; Ruby Pawankar; Lanny J Rosenwasser; Dana V Wallace; Richard W Weber; Cezmi A. Akdis; A Wesley Burks; Thomas B Casale; Stanley M Fineman; Dennis K Ledford; Richard F Lockey
We call for iCAALL: International Collaboration in Asthma, Allergy and Immunology.
The Journal of allergy and clinical immunology 2012;129(4):904-5.
2012: Sabine Plötz; Birgit Aigner; Cezmi A. Akdis; Knut Brockow; Ulf Darsow; Bettina Hüttig; Christian Merkel; Johannes Ring
Clinical overview of cutaneous features in hypereosinophilic syndrome.
Current allergy and asthma reports 2012;12(2):85-98.
2012: Norbert Meyer; Claudio Rhyner; Michael Soyka; Kerstin Wanke; Paulina Wawrzyniak; Sherrie Zhang; Mübeccel Akdis; Simone Bürgler; Maciej Chalubinski; Janine Christoph; Thomas Eiwegger; Hiroyuki Fujita; Philippe Indermitte; Heidi Makrinioti; Günter Menz; Cezmi A. Akdis
Inhibition of angiogenesis by IL-32: possible role in asthma.
The Journal of allergy and clinical immunology 2012;129(4):964-73.e7.
2012: Jan Lötvall; Nikolaos Papadopoulus; Ruby Pawankar; Lanny J Rosenwasser; Dana V Wallace; Richard W Weber; A Wesley Burks; Cezmi A. Akdis; Thomas B Casale; Stanley M Fineman; Dennis K Ledford; Richard F Lockey
We Call for iCAALL: International Collaboration in Asthma, Allergy and Immunology.
The World Allergy Organization journal 2012;5(3):39-40.
2012: Patrycja Konieczna; Eamonn M M Quigley; Fergus Shanahan; Mario Ziegler; Cezmi A. Akdis; Ruth Ferstl; Remo Frei; David Groeger; Barry Kiely; Liam O'Mahony
Bifidobacterium infantis 35624 administration induces Foxp3 T regulatory cells in human peripheral blood: potential role for myeloid and plasmacytoid dendritic cells.
Gut 2012;61(3):354-66.
2012: J Ring; Cezmi A. Akdis; M Akdis; W Ammann; H Behrendt; T Bieber; J Bienenstock; K Blaser; Bruce S Bochner; J Bousquet; R Crameri; A Custovic; C Czerkinsky; U Darsow; O de Beaumont; E M de Villiers; J Denburg; J Drazen; A Fire; S Galli; T Haahtela; S Hildemann; S Holgate; P Holt; T Jakob; A Jung; M Kemeny; H Koren; R P Lauener; D Leung; R Lockey; G Marone; M Mempel; B Menné; G Menz; U Mueller; M Ollert; L O'Mahony; R Pawankar; T Platts-Mills; H Renz; C Roduit; G Schäppi; C Schmidt-Weber; C Traidl-Hoffmann; E von Mutius; U Wahn; H zur Hausen; E Rietschel
Davos declaration: allergy as a global problem.
Allergy 2012;67(2):141-3.
2012: Oscar Palomares; Tuomo Puhakka; Beate Rückert; Andreas Speiser; Mübeccel Akdis; Heinz B Fahrner; Enrique Gomez; Tuomas Jartti; Andreas Jung; Livije Kalogjera; Umut Can Kücüksezer; William W Kwok; Cezmi A. Akdis
Induction and maintenance of allergen-specific FOXP3+ Treg cells in human tonsils as potential first-line organs of oral tolerance.
The Journal of allergy and clinical immunology 2012;129(2):510-20, 520.e1-9.
2012: Hiroyuki Fujita; Norbert Meyer; Mübeccel Akdis; Cezmi A. Akdis
Mechanisms of immune tolerance to allergens.
Chemical immunology and allergy 2012;96():30-8.
2012: Hiroyuki Fujita; Michael B Soyka; Mübeccel Akdis; Cezmi A. Akdis
Mechanisms of allergen-specific immunotherapy.
Clinical and translational allergy 2012;2(1):2.
2012: Elisabeth Mayer; Andreas Spittler; Zsolt Szépfalusi; Cezmi A. Akdis; Christina Bannert; Saskia Gruber; Sven Klunker; Thomas Eiwegger
Cord blood derived CD4+ CD25(high) T cells become functional regulatory T cells upon antigen encounter.
PloS one 2012;7(1):e29355.
2012: Ruth Ferstl; Cezmi A. Akdis; Liam O'Mahony
Histamine regulation of innate and adaptive immunity.
Frontiers in bioscience : a journal and virtual library 2012;17():40-53.
2012: Onur Boyman; Thomas Werfel; Cezmi A. Akdis
The suppressive role of IL-10 in contact and atopic dermatitis.
The Journal of allergy and clinical immunology 2012;129(1):160-1.
2011: B A Sin; J Zumkehr; Mübeccel Akdis; C Bekpen; S Bezzine; G Lambeau; Cezmi A. Akdis
T-cell and antibody responses to phospholipase A2 from different species show distinct cross-reactivity patterns.
Allergy 2011;66(12):1513-21.
2011: Liam O'Mahony; Mübeccel Akdis; Cezmi A. Akdis
Regulation of the immune response and inflammation by histamine and histamine receptors.
The Journal of allergy and clinical immunology 2011;128(6):1153-62.
2011: Cevdet Ozdemir; Mübeccel Akdis; Umut Can Kucuksezer; Cezmi A. Akdis
Specific immunotherapy and turning off the T cell: how does it work?
Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology 2011;107(5):381-92.
2011: Cezmi A. Akdis; Nikos Papadopoulos; Victoria Cardona
Fighting allergies beyond symptoms: the European Declaration on Immunotherapy.
European journal of immunology 2011;41(10):2802-4.
2011: Haner Direskeneli; Hiroyuki Fujita; Cezmi A. Akdis
Regulation of TH17 and regulatory T cells in patients with Behçet disease.
The Journal of allergy and clinical immunology 2011;128(3):665-6.
2011: C Ozdemir; Mübeccel Akdis; U C Kucuksezer; Cezmi A. Akdis
Mechanisms of immunotherapy to wasp and bee venom.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 2011;41(9):1226-34.
2011: Hiroyuki Fujita; Maciej Chalubinski; Claudio Rhyner; Philippe Indermitte; Norbert Meyer; Ruth Ferstl; Angela Treis; Enrique Gomez; Ahmet Akkaya; Liam O'Mahony; Mübeccel Akdis; Cezmi A. Akdis
Claudin-1 expression in airway smooth muscle exacerbates airway remodeling in asthmatic subjects.
The Journal of allergy and clinical immunology 2011;127(6):1612-21.e8.
2011: Thomas Eiwegger; Cezmi A. Akdis
IL-33 links tissue cells, dendritic cells and Th2 cell development in a mouse model of asthma.
European journal of immunology 2011;41(6):1535-8.
2011: Oscar Palomares; Liam O'Mahony; Cezmi A. Akdis
The many routes of dendritic cells to ensure immune regulation.
The Journal of allergy and clinical immunology 2011;127(6):1541-2.
2011: Marek Jutel; Cezmi A. Akdis
Immunological mechanisms of allergen-specific immunotherapy.
Allergy 2011;66(6):725-32.
2011: Ozge U Soyer; Mubeccel Akdis; Cezmi A. Akdis
Mechanisms of subcutaneous allergen immunotherapy.
Immunology and allergy clinics of North America 2011;31(2):175-90, vii-viii.
2011: J Bousquet; J Anto; C Auffray; M Akdis; A Cambon-Thomsen; T Keil; T Haahtela; B N Lambrecht; D S Postma; J Sunyer; R Valenta; Cezmi A. Akdis; I Annesi-Maesano; A Arno; C Bachert; F Ballester; X Basagana; U Baumgartner; C Bindslev-Jensen; B Brunekreef; K H Carlsen; L Chatzi; R Crameri; Eric Eveno; F Forastiere; J Garcia-Aymerich; S Guerra; H Hammad; J Heinrich; D Hirsch; B Jacquemin; F Kauffmann; M Kerkhof; M Kogevinas; G H Koppelman; M L Kowalski; S Lau; K C Lodrup-Carlsen; M Lopez-Botet; J Lotvall; C Lupinek; D Maier; M J Makela; Fernando D Martinez; J Mestres; I Momas; M C Nawijn; A Neubauer; S Oddie; S Palkonen; I Pin; C Pison; F Rancé; S Reitamo; E Rial-Sebbag; M Salapatas; V Siroux; D Smagghe; M Torrent; E Toskala; P van Cauwenberge; A J M van Oosterhout; R Varraso; L von Hertzen; M Wickman; cisca wijmenga; M Worm; J Wright; T Zuberbier
MeDALL (Mechanisms of the Development of ALLergy): an integrated approach from phenotypes to systems medicine.
Allergy 2011;66(5):596-604.
2011: Marek Jutel; Cezmi A. Akdis
T-cell subset regulation in atopy.
Current allergy and asthma reports 2011;11(2):139-45.
2011: Béatrice Vanbervliet; Mübeccel Akdis; Marc Vocanson; Aurore Rozières; Josette Benetière; Paul Rouzaire; Cezmi A. Akdis; Jean-François Nicolas; Anca Hennino
Histamine receptor H1 signaling on dendritic cells plays a key role in the IFN-γ/IL-17 balance in T cell-mediated skin inflammation.
The Journal of allergy and clinical immunology 2011;127(4):943-53.e1-10.
2011: S Vale-Pereira; Ana Todo-Bom; L Geraldes; C Schmidt-Weber; Cezmi A. Akdis; Anabela Mota-Pinto
FoxP3, GATA-3 and T-bet expression in elderly asthma.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 2011;41(4):490-6.
2011: Mübeccel Akdis; Simone Burgler; Reto Crameri; Thomas Eiwegger; Hiroyuki Fujita; Enrique Gomez; Sven Klunker; Norbert Meyer; Liam O'Mahony; Oscar Palomares; Claudio Rhyner; Nadia Quaked; Anna Schaffartzik; Willem Van De Veen; Sabine Zeller; Maya Zimmermann; Nadia Ouaked; Cezmi A. Akdis
Interleukins, from 1 to 37, and interferon-γ: receptors, functions, and roles in diseases.
The Journal of allergy and clinical immunology 2011;127(3):701-21.e1-70.
2011: Jan Lötvall; Cezmi A. Akdis; Leonard B Bacharier; Leif Bjermer; Thomas B Casale; Adnan Custovic; Robert F Lemanske; Andrew J Wardlaw; Sally E Wenzel; Paul A Greenberger
Asthma endotypes: a new approach to classification of disease entities within the asthma syndrome.
The Journal of allergy and clinical immunology 2011;127(2):355-60.
2011: Thomas Eiwegger; S Gruber; C Geiger; E Mayer; Eleonora Dehlink; C Bannert; Thomas Frischer; D Kasper; Peter Jaksch; Walter Klepetko; Cezmi A. Akdis; Zsolt Szépfalusi
Impact of systemic immuno-suppression after solid organ transplantation on allergen-specific responses.
Allergy 2011;66(2):271-8.
2011: Tunc Akkoc; Mübeccel Akdis; Cezmi A. Akdis
Update in the mechanisms of allergen-specific immunotheraphy.
Allergy, asthma & immunology research 2011;3(1):11-20.
2011: Maya Zimmermann; Andrea Koreck; Norbert Meyer; Tomasz Basinski; Flurina Meiler; Burgler Simone; Stefan Woehrl; Katharina Moritz; Thomas Eiwegger; Peter Schmid-Grendelmeier; Lajos Kemeny; Cezmi A. Akdis
TNF-like weak inducer of apoptosis (TWEAK) and TNF-α cooperate in the induction of keratinocyte apoptosis.
The Journal of allergy and clinical immunology 2011;127(1):200-7, 207.e1-10.
2011: Cezmi A. Akdis; Mübeccel Akdis
Mechanisms of allergen-specific immunotherapy.
The Journal of allergy and clinical immunology 2011;127(1):18-27; quiz 28-9.
2011: C Sackesen; E Birben; O U Soyer; U M Sahiner; T S Yavuz; E Civelek; E Karabulut; Mübeccel Akdis; Cezmi A. Akdis; O Kalayci
The effect of CD14 C159T polymorphism on in vitro IgE synthesis and cytokine production by PBMC from children with asthma.
Allergy 2011;66(1):48-57.
2010: Liam O'Mahony; Mubeccel Akdis; Reto Crameri; Cezmi A. Akdis
Novel immunotherapeutic approaches for allergy and asthma.
Autoimmunity 2010;43(7):493-503.
2010: Lorenzo Cecchi; G D'Amato; J G Ayres; C Galan; F Forastiere; B Forsberg; J Gerritsen; C Nunes; H Behrendt; Cezmi A. Akdis; R Dahl; I Annesi-Maesano
Projections of the effects of climate change on allergic asthma: the contribution of aerobiology.
Allergy 2010;65(9):1073-81.
2010: Simone Burgler; Pierre-Yves Mantel; Claudio Bassin; Nadia Ouaked; Cezmi A. Akdis; Carsten B Schmidt-Weber
RORC2 is involved in T cell polarization through interaction with the FOXP3 promoter.
Journal of immunology (Baltimore, Md. : 1950) 2010;184(11):6161-9.
2010: Oscar Palomares; Görkem Yaman; Ahmet K Azkur; Tunc Akkoc; Mübeccel Akdis; Cezmi A. Akdis
Role of Treg in immune regulation of allergic diseases.
European journal of immunology 2010;40(5):1232-40.
2010: Norbert Meyer; Maya Zimmermann; Simone Bürgler; Claudio Bassin; Stefan Woehrl; Katharina Moritz; Claudio Rhyner; Philippe Indermitte; Peter Schmid-Grendelmeier; Mübeccel Akdis; Günter Menz; Cezmi A. Akdis
IL-32 is expressed by human primary keratinocytes and modulates keratinocyte apoptosis in atopic dermatitis.
The Journal of allergy and clinical immunology 2010;125(4):858-865.e10.
2010: ATIL BISGIN; Ender Terzioglu; Cigdem Aydin; Burcak Yoldas; Veli Yazisiz; Nilufer Balci; Huseyin Bagci; Reginald M Gorczynski; Cezmi A. Akdis; Salih Sanlioglu
TRAIL death receptor-4, decoy receptor-1 and decoy receptor-2 expression on CD8+ T cells correlate with the disease severity in patients with rheumatoid arthritis.
BMC musculoskeletal disorders 2010;11():192.
2010: Cevdet Ozdemir; Mübeccel Akdis; Cezmi A. Akdis
T-cell response to allergens.
Chemical immunology and allergy 2010;95():22-44.
2009: Marek Jutel; Mübeccel Akdis; Cezmi A. Akdis
Histamine, histamine receptors and their role in immune pathology.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 2009;39(12):1786-800.
2009: Reto Crameri; Thomas M Kündig; Cezmi A. Akdis
Modular antigen-translocation as a novel vaccine strategy for allergen-specific immunotherapy.
Current opinion in allergy and clinical immunology 2009;9(6):568-73.
2009: Sven Klunker; Mark M W Chong; Pierre-Yves Mantel; Oscar Palomares; Claudio Bassin; Mario Ziegler; Beate Rückert; Flurina Meiler; Mübeccel Akdis; Dan R Littman; Cezmi A. Akdis
Transcription factors RUNX1 and RUNX3 in the induction and suppressive function of Foxp3+ inducible regulatory T cells.
The Journal of experimental medicine 2009;206(12):2701-15.
2009: Mübeccel Akdis; Cezmi A. Akdis
Therapeutic manipulation of immune tolerance in allergic disease.
Nature reviews. Drug discovery 2009;8(8):645-60.
2009: Sabine Zeller; Claudio Rhyner; Norbert Meyer; Peter Schmid-Grendelmeier; Cezmi A. Akdis; Reto Crameri
Exploring the repertoire of IgE-binding self-antigens associated with atopic eczema.
The Journal of allergy and clinical immunology 2009;124(2):278-85, 285.e1-7.
2009: Tomasz M Basinski; David Holzmann; Thomas Eiwegger; Maya Zimmermann; Sven Klunker; Norbert Meyer; Peter Schmid-Grendelmeier; Marek Jutel; Cezmi A. Akdis
Dual nature of T cell-epithelium interaction in chronic rhinosinusitis.
The Journal of allergy and clinical immunology 2009;124(1):74-80.e1-8.
2009: J Bousquet; P G Burney; T Zuberbier; P V Cauwenberge; Cezmi A. Akdis; C Bindslev-Jensen; S Bonini; W J Fokkens; F Kauffmann; Marek Kowalski; K Lodrup-Carlsen; J Mullol; E Nizankowska-Mogilnicka; N Papadopoulos; E Toskala; M Wickman; J Anto; N Auvergne; C Bachert; P J Bousquet; B Brunekreef; G W Canonica; K H Carlsen; M Gjomarkaj; T Haahtela; P Howarth; G Lenzen; J Lotvall; K Radon; J Ring; M Salapatas; H J Schünemann; A Szczecklik; A Todo-Bom; E Valovirta; E von Mutius; J P Zock
GA2LEN (Global Allergy and Asthma European Network) addresses the allergy and asthma 'epidemic'.
Allergy 2009;64(7):969-77.
2009: K Solarewicz-Madejek; T M Basinski; Reto Crameri; Mübeccel Akdis; A Akkaya; Kurt Blaser; K F Rabe; Cezmi A. Akdis; Marek Jutel
T cells and eosinophils in bronchial smooth muscle cell death in asthma.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 2009;39(6):845-55.
2009: Cevdet Ozdemir; Mübeccel Akdis; Cezmi A. Akdis
T regulatory cells and their counterparts: masters of immune regulation.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 2009;39(5):626-39.
2009: Cezmi A. Akdis
T cells in health and disease.
The Journal of allergy and clinical immunology 2009;123(5):1022-3.
2009: Cezmi A. Akdis; Mübeccel Akdis
Mechanisms and treatment of allergic disease in the big picture of regulatory T cells.
The Journal of allergy and clinical immunology 2009;123(4):735-46; quiz 747-8.
2009: Claus Bachert; N Van Bruaene; E Toskala; Nan Zhang; H Olze; Glenis Scadding; C M Van Drunen; Joaquim Mullol; L Cardell; Philippe Gevaert; Thibaut Van Zele; Sofie Claeys; C Halldén; K Kostamo; U Foerster; M Kowalski; K Bieniek; A Olszewska-Ziaber; E Nizankowska-Mogilnicka; A Szczeklik; M Swierczynska; M Arcimowicz; Valerie Lund; W Fokkens; T Zuberbier; Cezmi A. Akdis; G Canonica; Paul van Cauwenberge; Peter Burney; Jean Bousquet
Important research questions in allergy and related diseases: 3-chronic rhinosinusitis and nasal polyposis - a GALEN study.
Allergy 2009;64(4):520-33.
2009: Simone Burgler; Nadia Ouaked; Claudio Bassin; Tomasz M Basinski; Pierre-Yves Mantel; Kerstin Siegmund; Norbert Meyer; Cezmi A. Akdis; Carsten B Schmidt-Weber
Differentiation and functional analysis of human T(H)17 cells.
The Journal of allergy and clinical immunology 2009;123(3):588-95, 595.e1-7.
2009: Kerstin Siegmund; Beate Rückert; Nadia Ouaked; Simone Bürgler; Andreas Speiser; Cezmi A. Akdis; Carsten B Schmidt-Weber
Unique phenotype of human tonsillar and in vitro-induced FOXP3+CD8+ T cells.
Journal of immunology (Baltimore, Md. : 1950) 2009;182(4):2124-30.
2009: Alison Taylor; Johan Verhagen; Tunç Akkoç; Renate Wenig; Egbert Flory; Kurt Blaser; Mübeccel Akdis; Cezmi A. Akdis
IL-10 suppresses CD2-mediated T cell activation via SHP-1.
Molecular immunology 2009;46(4):622-9.
2009: Nadia Ouaked; Pierre-Yves Mantel; Claudio Bassin; Simone Burgler; Kerstin Siegmund; Cezmi A. Akdis; Carsten B Schmidt-Weber
Regulation of the foxp3 gene by the Th1 cytokines: the role of IL-27-induced STAT1.
Journal of immunology (Baltimore, Md. : 1950) 2009;182(2):1041-9.
2009: Stefan Wöhrl; Katja Radon; Johannes Ring; Katharina Moritz; Cezmi A. Akdis; Peter Burney; Paul Van Cauwenberge; Jean Bousquet; Torsten Zuberbier
[GA2LEN (Global Allergy and Asthma European Network), the perspective of the German speaking centers].
Wiener klinische Wochenschrift 2009;121(17-18):589-97.
2008: Flurina Meiler; Judith Zumkehr; Sven Klunker; Beate Rückert; Cezmi A. Akdis; Mübeccel Akdis
In vivo switch to IL-10-secreting T regulatory cells in high dose allergen exposure.
The Journal of experimental medicine 2008;205(12):2887-98.
2008: F Meiler; Sven Klunker; M Zimmermann; Cezmi A. Akdis; Mübeccel Akdis
Distinct regulation of IgE, IgG4 and IgA by T regulatory cells and toll-like receptors.
Allergy 2008;63(11):1455-63.
2008: Ulrich R Müller; Marek Jutel; Andrea Reimers; Judith Zumkehr; Clarissa Huber; Carola Kriegel; Urs Steiner; Gabrielle Haeberli; Mübeccel Akdis; Arthur Helbling; Benno Schnyder; Kurt Blaser; Cezmi A. Akdis
Clinical and immunologic effects of H1 antihistamine preventive medication during honeybee venom immunotherapy.
The Journal of allergy and clinical immunology 2008;122(5):1001-1007.e4.
2008: Cezmi A. Akdis
New insights into mechanisms of immunoregulation in 2007.
The Journal of allergy and clinical immunology 2008;122(4):700-9.
2008: Cevdet Ozdemir; Mübeccel Akdis; Cezmi A. Akdis
Nature of regulatory T cells in the context of allergic disease.
Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology 2008;4(3):106-10.
2008: J Bousquet; W Fokkens; P Burney; S R Durham; C Bachert; Cezmi A. Akdis; G W Canonica; S-E Dahlen; T Zuberbier; T Bieber; S Bonini; P J Bousquet; J L Brozek; L-O Cardell; R Crameri; A Custovic; P Demoly; R G van Wijk; M Gjomarkaj; C Holland; P Howarth; M Humbert; S L Johnston; F Kauffmann; Marek Kowalski; B Lambrecht; S Lehmann; B Leynaert; K Lodrup-Carlsen; J Mullol; B Niggemann; E Nizankowska-Mogilnicka; N Papadopoulos; G Passalacqua; H J Schünemann; H-U Simon; A Todo-Bom; E Toskala; R Valenta; M Wickman; J P Zock
Important research questions in allergy and related diseases: nonallergic rhinitis: a GA2LEN paper.
Allergy 2008;63(7):842-53.
2008: Cezmi A. Akdis
Immune regulation by histamine H4 receptors in skin.
The Journal of investigative dermatology 2008;128(7):1615-6.
2008: Nicholas Van Bruaene; Claudina Angela Pérez-Novo; Tomasz M Basinski; Thibaut Van Zele; Gabriele Holtappels; Natalie De Ruyck; Carsten Schmidt-Weber; Cezmi A. Akdis; Paul van Cauwenberge; Claus Bachert; Philippe Gevaert
T-cell regulation in chronic paranasal sinus disease.
The Journal of allergy and clinical immunology 2008;121(6):1435-41, 1441.e1-3.
2008: Irene Mittermann; Renate Reininger; Maya Zimmermann; Katharina Gangl; Jürgen Reisinger; Karl J Aichberger; Elli K Greisenegger; Verena Niederberger; Joachim Seipelt; Barbara Bohle; Tamara Kopp; Cezmi A. Akdis; Susanne Spitzauer; Peter Valent; Rudolf Valenta
The IgE-reactive autoantigen Hom s 2 induces damage of respiratory epithelial cells and keratinocytes via induction of IFN-gamma.
The Journal of investigative dermatology 2008;128(6):1451-9.
2008: Tunc Akkoc; Pieter J A de Koning; Beate Rückert; Isil Barlan; Mübeccel Akdis; Cezmi A. Akdis
Increased activation-induced cell death of high IFN-gamma-producing T(H)1 cells as a mechanism of T(H)2 predominance in atopic diseases.
The Journal of allergy and clinical immunology 2008;121(3):652-658.e1.
2008: J Bousquet; Thomas Bieber; Wytske Fokkens; Marek Kowalski; M Humbert; B Niggemann; H-U Simon; P Burney; Paul van Cauwenberge; T Zuberbier; Cezmi A. Akdis; Pascal Demoly
Important questions in allergy: novel research areas.
Allergy 2008;63(2):143-7.
2008: Günnur Deniz; Gaye Erten; Umut Can Kücüksezer; Dilara Kocacik; Christian Karagiannidis; Esin Aktas; Cezmi A. Akdis; Mübeccel Akdis
Regulatory NK cells suppress antigen-specific T cell responses.
Journal of immunology (Baltimore, Md. : 1950) 2008;180(2):850-7.
2008: Marek Jutel; Cezmi A. Akdis
T-cell regulatory mechanisms in specific immunotherapy.
Chemical immunology and allergy 2008;94():158-77.
2008: Cezmi A. Akdis; Marek Jutel; Mübeccel Akdis
Regulatory effects of histamine and histamine receptor expression in human allergic immune responses.
Chemical immunology and allergy 2008;94():67-82.
2007: Pierre-Yves Mantel; Harmjan Kuipers; Onur Boyman; Claudio Rhyner; Nadia Ouaked; Beate Rückert; Christian Karagiannidis; Bart N Lambrecht; Rudolf W Hendriks; Reto Crameri; Cezmi A. Akdis; Kurt Blaser; Carsten B Schmidt-Weber
GATA3-driven Th2 responses inhibit TGF-beta1-induced FOXP3 expression and the formation of regulatory T cells.
PLoS biology 2007;5(12):e329.
2007: Cevdet Ozdemir; Cezmi A. Akdis
Discontinued drugs in 2006: pulmonary-allergy, dermatological, gastrointestinal and arthritis drugs.
Expert opinion on investigational drugs 2007;16(9):1327-44.
2007: Carsten B Schmidt-Weber; Mübeccel Akdis; Cezmi A. Akdis
TH17 cells in the big picture of immunology.
The Journal of allergy and clinical immunology 2007;120(2):247-54.
2007: Sarah Thunberg; Mübeccel Akdis; Cezmi A. Akdis; Reidar Grönneberg; Vivianne Malmström; Christina Trollmo; Marianne van Hage; Guro Gafvelin
Immune regulation by CD4+CD25+ T cells and interleukin-10 in birch pollen-allergic patients and non-allergic controls.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 2007;37(8):1127-36.
2007: Claudio Rhyner; Thomas M Kündig; Cezmi A. Akdis; Reto Crameri
Targeting the MHC II presentation pathway in allergy vaccine development.
Biochemical Society transactions 2007;35(Pt 4):833-4.
2007: Alison Taylor; Mübeccel Akdis; Andrea Joss; Tunç Akkoç; Renate Wenig; Marco COLONna; Isabelle Daigle; Egbert Flory; Kurt Blaser; Cezmi A. Akdis
IL-10 inhibits CD28 and ICOS costimulations of T cells via src homology 2 domain-containing protein tyrosine phosphatase 1.
The Journal of allergy and clinical immunology 2007;120(1):76-83.
2007: Metin Aydogan; Nihal Mete; Didem Yazi; Tunc Akkoc; Cevdet Ozdemir; Kurt Blaser; Mübeccel Akdis; Cezmi A. Akdis; Nerin N Bahceciler; Isil B Barlan
Comparison of Der p1-specific antibody levels in children with allergic airway disease and healthy controls.
Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology 2007;18(4):320-5.
2007: Steffen Kunzmann; Carsten B Schmidt-Weber; Jean-Marc Zingg; Angelo Azzi; Boris W Kramer; Kurt Blaser; Cezmi A. Akdis; Christian P Speer
Connective tissue growth factor expression is regulated by histamine in lung fibroblasts: potential role of histamine in airway remodeling.
The Journal of allergy and clinical immunology 2007;119(6):1398-407.
2007: Sivaraman Padavattan; Tilman Schirmer; Margit Schmidt; Cezmi A. Akdis; Rudolf Valenta; Irene Mittermann; Lyudmilla Soldatova; Jay Slater; Ulrich Mueller; Zora Markovic-Housley
Identification of a B-cell epitope of hyaluronidase, a major bee venom allergen, from its crystal structure in complex with a specific Fab.
Journal of molecular biology 2007;368(3):742-52.
2007: Mübeccel Akdis; Cezmi A. Akdis
Mechanisms of allergen-specific immunotherapy.
The Journal of allergy and clinical immunology 2007;119(4):780-91.
2007: M Jutel; Cezmi A. Akdis
Histamine as an immune modulator in chronic inflammatory responses.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 2007;37(3):308-10.
2007: Cigdem Aydin; Ahter D Sanlioglu; Bahri Karacay; Gülay Ozbilim; Levent Dertsiz; Omer Ozbudak; Cezmi A. Akdis; Salih Sanlioglu
Decoy receptor-2 small interfering RNA (siRNA) strategy employing three different siRNA constructs in combination defeats adenovirus-transferred tumor necrosis factor-related apoptosis-inducing ligand resistance in lung cancer cells.
Human gene therapy 2007;18(1):39-50.
2007: T Basinski; C Ozdemir; C Sackesen; Pierre-Yves Mantel; Isil B Barlan; Mübeccel Akdis; Marek Jutel; Cezmi A. Akdis
Highlights in cellular and molecular mechanisms of allergic diseases. XXVth Congress of the European Academy of Allergology and Clinical Immunology in Vienna.
International archives of allergy and immunology 2007;142(2):91-8.
2006: Cezmi A. Akdis
Allergy and hypersensitivity: mechanisms of allergic disease.
Current opinion in immunology 2006;18(6):718-26.
2006: Mark Larché; Cezmi A. Akdis; Rudolf Valenta
Immunological mechanisms of allergen-specific immunotherapy.
Nature reviews. Immunology 2006;6(10):761-71.
2006: Cezmi A. Akdis; Mübeccel Akdis; Thomas Bieber; Carsten Bindslev-Jensen; M Boguniewicz; Philippe Eigenmann; Q Hamid; A Kapp; D Y M Leung; Jasna Lipozencic; T A Luger; Antonella Muraro; N Novak; Thomas A E Platts-Mills; L Rosenwasser; Annika Scheynius; Estelle Simons; Jonathan M Spergel; K Turjanmaa; Ulrich Wahn; S Weidinger; Thomas Werfel; Torsten Zuberbier
Diagnosis and treatment of atopic dermatitis in children and adults: European Academy of Allergology and Clinical Immunology/American Academy of Allergy, Asthma and Immunology/PRACTALL Consensus Report.
Allergy 2006;61(8):969-87.
2006: Cezmi A. Akdis; Mübeccel Akdis; Thomas Bieber; Carsten Bindslev-Jensen; Mark Boguniewicz; Philippe Eigenmann; Qutayba Hamid; Alexander Kapp; Donald Y M Leung; Jasna Lipozencic; Thomas A Luger; Antonella Muraro; Natalija Novak; Thomas A E Platts-Mills; Lanny Rosenwasser; Annika Scheynius; Estelle Simons; Jonathan M Spergel; Kristiina Turjanmaa; Ulrich Wahn; Stefan Weidinger; Thomas Werfel; Torsten Zuberbier
Diagnosis and treatment of atopic dermatitis in children and adults: European Academy of Allergology and Clinical Immunology/American Academy of Allergy, Asthma and Immunology/PRACTALL Consensus Report.
The Journal of allergy and clinical immunology 2006;118(1):152-69.
2006: Marek Jutel; Mübeccel Akdis; Kurt Blaser; Cezmi A. Akdis
Mechanisms of allergen specific immunotherapy--T-cell tolerance and more.
Allergy 2006;61(7):796-807.
2006: Isil B Barlan; Nerin N Bahceciler; Mübeccel Akdis; Cezmi A. Akdis
Bacillus Calmette-Guerin, Mycobacterium bovis, as an immunomodulator in atopic diseases.
Immunology and allergy clinics of North America 2006;26(2):365-77, ix.
2006: Marek Jutel; Kurt Blaser; Cezmi A. Akdis
Histamine receptors in immune regulation and allergen-specific immunotherapy.
Immunology and allergy clinics of North America 2006;26(2):245-59, vii.
2006: Johan Verhagen; Kurt Blaser; Cezmi A. Akdis; Mübeccel Akdis
Mechanisms of allergen-specific immunotherapy: T-regulatory cells and more.
Immunology and allergy clinics of North America 2006;26(2):207-31, vi.
2006: Cezmi A. Akdis
Future of allergen-specific immunotherapy: better understanding of the mechanisms, novel treatments, and long-term cure.
Immunology and allergy clinics of North America 2006;26(2):xiii-xxii.
2006: Michael Tarzi; Sven Klunker; Catherine Texier; Adrienne Verhoef; S O Stapel; Cezmi A. Akdis; Bernard Maillere; A Barry Kay; Mark Larché
Induction of interleukin-10 and suppressor of cytokine signalling-3 gene expression following peptide immunotherapy.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 2006;36(4):465-74.
2006: Alison Taylor; Johan Verhagen; Kurt Blaser; Mübeccel Akdis; Cezmi A. Akdis
Mechanisms of immune suppression by interleukin-10 and transforming growth factor-beta: the role of T regulatory cells.
Immunology 2006;117(4):433-42.
2006: Cezmi A. Akdis; Estelle Simons
Histamine receptors are hot in immunopharmacology.
European journal of pharmacology 2006;533(1-3):69-76.
2006: Flurina Meiler; Maya Zimmermann; Kurt Blaser; Cezmi A. Akdis; Mübeccel Akdis
T-cell subsets in the pathogenesis of human asthma.
Current allergy and asthma reports 2006;6(2):91-6.
2006: Haluk B Oral; Sergei V Kotenko; Mustafa Yilmaz; Orlando Mani; Judith Zumkehr; Kurt Blaser; Cezmi A. Akdis; Mübeccel Akdis
Regulation of T cells and cytokines by the interleukin-10 (IL-10)-family cytokines IL-19, IL-20, IL-22, IL-24 and IL-26.
European journal of immunology 2006;36(2):380-8.
2006: Cezmi A. Akdis; Isil B Barlan; Nerin N Bahceciler; Mübeccel Akdis
Immunological mechanisms of sublingual immunotherapy.
Allergy 2006;61 Suppl 81():11-4.
2006: Johan Verhagen; Mübeccel Akdis; Claudia Traidl-Hoffmann; Peter Schmid-Grendelmeier; Dirk Hijnen; Edward F Knol; Heidrun Behrendt; Kurt Blaser; Cezmi A. Akdis
Absence of T-regulatory cell expression and function in atopic dermatitis skin.
The Journal of allergy and clinical immunology 2006;117(1):176-83.
2006: Cezmi A. Akdis; Kurt Blaser; Mübeccel Akdis
Mechanisms of allergen-specific immunotherapy.
Chemical immunology and allergy 2006;91():195-203.
2006: Marek Jutel; Kurt Blaser; Cezmi A. Akdis
The role of histamine in regulation of immune responses.
Chemical immunology and allergy 2006;91():174-87.
2006: Mübeccel Akdis; Kurt Blaser; Cezmi A. Akdis
T regulatory cells in allergy.
Chemical immunology and allergy 2006;91():159-73.
2005: Isil B Barlan; Nerin N Bahceciler; Mübeccel Akdis; Cezmi A. Akdis
Role of bacillus Calmette-Guérin as an immunomodulator for the prevention and treatment of allergy and asthma.
Current opinion in allergy and clinical immunology 2005;5(6):552-7.
2005: Mübeccel Akdis; Kurt Blaser; Cezmi A. Akdis
T regulatory cells in allergy: novel concepts in the pathogenesis, prevention, and treatment of allergic diseases.
The Journal of allergy and clinical immunology 2005;116(5):961-8; quiz 969.
2005: Fariba Karamloo; Peter Schmid-Grendelmeier; Fatimah Kussebi; Mübeccel Akdis; Maria Salagianni; Barbara R von Beust; Andrea Reimers; Judith Zumkehr; Lyudmilla Soldatova; Zora Housley-Markovic; Ulrich Müller; Thomas M Kündig; David M Kemeny; Michael D Spangfort; Kurt Blaser; Cezmi A. Akdis
Prevention of allergy by a recombinant multi-allergen vaccine with reduced IgE binding and preserved T cell epitopes.
European journal of immunology 2005;35(11):3268-76.
2005: Axel Trautmann; Katja Kruger; Mübeccel Akdis; Dietrich Muller-Wening; Ahmet Akkaya; Eva-Bettina Brocker; Kurt Blaser; Cezmi A. Akdis
Apoptosis and loss of adhesion of bronchial epithelial cells in asthma.
International archives of allergy and immunology 2005;138(2):142-50.
2005: Johan Verhagen; Alison Taylor; Kurt Blaser; Mübeccel Akdis; Cezmi A. Akdis
T regulatory cells in allergen-specific immunotherapy.
International reviews of immunology 2005;24(5-6):533-48.
2005: Guro Gafvelin; Sarah Thunberg; Marianne Kronqvist; Hans Grönlund; Reidar Grönneberg; Marita Troye-Blomberg; Mübeccel Akdis; Helmut Fiebig; Ashok Purohit; Friedrich Horak; Jürgen Reisinger; Verena Niederberger; Cezmi A. Akdis; Oliver Cromwell; Gabrielle Pauli; Rudolf Valenta; Marianne van Hage
Cytokine and antibody responses in birch-pollen-allergic patients treated with genetically modified derivatives of the major birch pollen allergen Bet v 1.
International archives of allergy and immunology 2005;138(1):59-66.
2005: Marek Jutel; Mübeccel Akdis; Kurt Blaser; Cezmi A. Akdis
Are regulatory T cells the target of venom immunotherapy?
Current opinion in allergy and clinical immunology 2005;5(4):365-9.
2005: Alison Taylor; Johan Verhagen; Cezmi A. Akdis; Mübeccel Akdis
T regulatory cells and allergy.
Microbes and infection / Institut Pasteur 2005;7(7-8):1049-55.
2005: Marek Jutel; Kurt Blaser; Cezmi A. Akdis
Histamine in allergic inflammation and immune modulation.
International archives of allergy and immunology 2005;137(1):82-92.
2005: Esin Aktas; Mübeccel Akdis; Sema Bilgic; Rainer Disch; C S Falk; K Blaser; Cezmi A. Akdis; Günnur Deniz
Different natural killer (NK) receptor expression and immunoglobulin E (IgE) regulation by NK1 and NK2 cells.
Clinical and experimental immunology 2005;140(2):301-9.
2005: Johan Verhagen; Alison Taylor; Mübeccel Akdis; Cezmi A. Akdis
Targets in allergy-directed immunotherapy.
Expert opinion on therapeutic targets 2005;9(2):217-24.
2005: Johan Verhagen; Alison Taylor; Cezmi A. Akdis; Mübeccel Akdis
Advances in allergen-specific immunotherapy.
Expert opinion on biological therapy 2005;5(4):537-44.
2005: Nerin N Bahceciler; Cigdem Arikan; Alison Taylor; Mübeccel Akdis; Kurt Blaser; Isil B Barlan; Cezmi A. Akdis
Impact of sublingual immunotherapy on specific antibody levels in asthmatic children allergic to house dust mites.
International archives of allergy and immunology 2005;136(3):287-94.
2005: Cezmi A. Akdis
Future of allergen-specific immunotherapy.
Expert opinion on emerging drugs 2005;10(1):1-4.
2005: Fatimah Kussebi; Fariba Karamloo; Claudio Rhyner; Peter Schmid-Grendelmeier; Maria Salagianni; Christian Mannhart; Mübeccel Akdis; Lyudmilla Soldatova; Zora Markovic-Housley; Barbara R Von Beust; Thomas M Kündig; David M Kemeny; Kurt Blaser; Reto Crameri; Cezmi A. Akdis
A major allergen gene-fusion protein for potential usage in allergen-specific immunotherapy.
The Journal of allergy and clinical immunology 2005;115(2):323-9.
2005: Marek Jutel; Kurt Blaser; Cezmi A. Akdis
Histamine in chronic allergic responses.
Journal of investigational allergology & clinical immunology : official organ of the International Association of Asthmology (INTERASMA) and Sociedad Latinoamericana de Alergia e Inmunología 2005;15(1):1-8.
2004: Christian Karagiannidis; Mübeccel Akdis; Päivi Holopainen; Niina J Woolley; Gabriele Hense; Beate Rückert; Pierre-Yves Mantel; Günter Menz; Cezmi A. Akdis; Kurt Blaser; Carsten B Schmidt-Weber
Glucocorticoids upregulate FOXP3 expression and regulatory T cells in asthma.
The Journal of allergy and clinical immunology 2004;114(6):1425-33.
2004: Cezmi A. Akdis; Kurt Blaser; Mübeccel Akdis
Apoptosis in tissue inflammation and allergic disease.
Current opinion in immunology 2004;16(6):717-23.
2004: Alison Taylor; Johan Verhagen; Cezmi A. Akdis; Mübeccel Akdis
T regulatory cells in allergy and health: a question of allergen specificity and balance.
International archives of allergy and immunology 2004;135(1):73-82.
2004: Cezmi A. Akdis; Kurt Blaser; Mübeccel Akdis
Genes of tolerance.
Allergy 2004;59(9):897-913.
2004: Mübeccel Akdis; Johan Verhagen; Alison Taylor; Fariba Karamloo; Christian Karagiannidis; Reto Crameri; Sarah Thunberg; Günnur Deniz; Rudolf Valenta; Helmut Fiebig; Christian Kegel; Rainer Disch; Carsten B Schmidt-Weber; Kurt Blaser; Cezmi A. Akdis
Immune responses in healthy and allergic individuals are characterized by a fine balance between allergen-specific T regulatory 1 and T helper 2 cells.
The Journal of experimental medicine 2004;199(11):1567-75.
2004: Cigdem Arikan; Nerin N Bahceciler; Günnur Deniz; Mübeccel Akdis; Tunc Akkoc; Cezmi A. Akdis; Isil B Barlan
Bacillus Calmette-Guérin-induced interleukin-12 did not additionally improve clinical and immunologic parameters in asthmatic children treated with sublingual immunotherapy.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 2004;34(3):398-405.
2004: K Blaser; Cezmi A. Akdis
Interleukin-10, T regulatory cells and specific allergy treatment.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 2004;34(3):328-31.
2004: Mübeccel Akdis; Sven Klunker; Kurt Blaser; Cezmi A. Akdis
Skin homing T cells.
Ernst Schering Research Foundation workshop 2004;(44):15-26.
2003: Cezmi A. Akdis; M Akdis
Immunological differences between intrinsic and extrinsic types of atopic dermatitis.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 2003;33(12):1618-21.
2003: Cezmi A. Akdis; Fatimah Kussebi; Bali Pulendran; Mübeccel Akdis; Roger Lauener; Carsten B Schmidt-Weber; Sven Klunker; Gülbu Isitmangil; Natasha Hansjee; Thomas A Wynn; Stephanie Dillon; Peter Erb; Gerhard Baschang; Kurt Blaser; Sefik Alkan
Inhibition of T helper 2-type responses, IgE production and eosinophilia by synthetic lipopeptides.
European journal of immunology 2003;33(10):2717-26.
2003: Jan G Wohlfahrt; Steffen Kunzmann; Günter Menz; Werner Kneist; Cezmi A. Akdis; Kurt Blaser; Carsten B Schmidt-Weber
T cell phenotype in allergic asthma and atopic dermatitis.
International archives of allergy and immunology 2003;131(4):272-82.
2003: Sven Klunker; Axel Trautmann; Mübeccel Akdis; Johan Verhagen; Peter Schmid-Grendelmeier; Kurt Blaser; Cezmi A. Akdis
A second step of chemotaxis after transendothelial migration: keratinocytes undergoing apoptosis release IFN-gamma-inducible protein 10, monokine induced by IFN-gamma, and IFN-gamma-inducible alpha-chemoattractant for T cell chemotaxis toward epidermis in atopic dermatitis.
Journal of immunology (Baltimore, Md. : 1950) 2003;171(2):1078-84.
2003: Cezmi A. Akdis; Kurt Blaser
Histamine in the immune regulation of allergic inflammation.
The Journal of allergy and clinical immunology 2003;112(1):15-22.
2003: Mübeccel Akdis; Axel Trautmann; Sven Klunker; Isabelle Daigle; Umut C Kucuksezer; Wolfgang Deglmann; Rainer Disch; Kurt Blaser; Cezmi A. Akdis
T helper (Th) 2 predominance in atopic diseases is due to preferential apoptosis of circulating memory/effector Th1 cells.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2003;17(9):1026-35.
2003: Marek Jutel; Mübeccel Akdis; Ferah Budak; Carmen Aebischer-Casaulta; Maria Wrzyszcz; Kurt Blaser; Cezmi A. Akdis
IL-10 and TGF-beta cooperate in the regulatory T cell response to mucosal allergens in normal immunity and specific immunotherapy.
European journal of immunology 2003;33(5):1205-14.
2003: Axel Trautmann; Beate Rückert; Peter Schmid-Grendelmeier; Eva Niederer; Eva-B Bröcker; Kurt Blaser; Cezmi A. Akdis
Human CD8 T cells of the peripheral blood contain a low CD8 expressing cytotoxic/effector subpopulation.
Immunology 2003;108(3):305-12.
2003: Steffen Kunzmann; Jan G Wohlfahrt; S Itoh; H Asao; M Komada; Cezmi A. Akdis; Kurt Blaser; Carsten B Schmidt-Weber
SARA and Hgs attenuate susceptibility to TGF-beta1-mediated T cell suppression.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2003;17(2):194-202.
2003: Carmen Casaulta; Martin H Schöni; Michael Weichel; Reto Crameri; Marek Jutel; Isabelle Daigle; Mübeccel Akdis; Kurt Blaser; Cezmi A. Akdis
IL-10 controls Aspergillus fumigatus- and Pseudomonas aeruginosa-specific T-cell response in cystic fibrosis.
Pediatric research 2003;53(2):313-9.
2003: Axel Trautmann; Rainer Disch; Eva-B Bröcker; Cezmi A. Akdis; Reinhard Gillitzer
[How does eczema arise?].
Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG 2003;1(1):8-11.
2003: Cezmi A. Akdis; Kurt Blaser
Mechanisms of specific immunotherapy: current knowledge.
Arbeiten aus dem Paul-Ehrlich-Institut (Bundesamt für Sera und Impfstoffe) zu Frankfurt a.M 2003;(94):219-27; discussion 227-8.
2002: Marek Jutel; Takeshi Watanabe; Mübeccel Akdis; Kurt Blaser; Cezmi A. Akdis
Immune regulation by histamine.
Current opinion in immunology 2002;14(6):735-40.
2002: Carsten B Schmidt-Weber; Jan G Wohlfahrt; Cezmi A. Akdis; Kurt Blaser
The phosphatidylinositol phosphatase PTEN is under control of costimulation and regulates proliferation in human T cells.
European journal of immunology 2002;32(4):1196-204.
2002: Günnur Deniz; Mübeccel Akdis; Esin Aktas; Kurt Blaser; Cezmi A. Akdis
Human NK1 and NK2 subsets determined by purification of IFN-gamma-secreting and IFN-gamma-nonsecreting NK cells.
European journal of immunology 2002;32(3):879-84.
2002: Axel Trautmann; Peter Schmid-Grendelmeier; Katja Krüger; Reto Crameri; Mübeccel Akdis; Ahmet Akkaya; Eva-B Bröcker; Kurt Blaser; Cezmi A. Akdis
T cells and eosinophils cooperate in the induction of bronchial epithelial cell apoptosis in asthma.
The Journal of allergy and clinical immunology 2002;109(2):329-37.
2002: Mübeccel Akdis; Axel Trautmann; Kurt Blaser; Cezmi A. Akdis
T cells and effector mechanisms in the pathogenesis of atopic dermatitis.
Current allergy and asthma reports 2002;2(1):1-3.
2001: Axel Trautmann; Mübeccel Akdis; Peter Schmid-Grendelmeier; Rainer Disch; Eva-B Bröcker; Kurt Blaser; Cezmi A. Akdis
Targeting keratinocyte apoptosis in the treatment of atopic dermatitis and allergic contact dermatitis.
The Journal of allergy and clinical immunology 2001;108(5):839-46.
2001: Axel Trautmann; F Altznauer; Mübeccel Akdis; Hans-Uwe Simon; Rainer Disch; Eva-B Bröcker; Kurt Blaser; Cezmi A. Akdis
The differential fate of cadherins during T-cell-induced keratinocyte apoptosis leads to spongiosis in eczematous dermatitis.
The Journal of investigative dermatology 2001;117(4):927-34.
2001: A Trautmann; M Akdis; E B Bröcker; K Blaser; Cezmi A. Akdis
New insights into the role of T cells in atopic dermatitis and allergic contact dermatitis.
Trends in immunology 2001;22(10):530-2.
2001: Marek Jutel; T Watanabe; Sven Klunker; Mübeccel Akdis; Olivier Thomet; Józef Malolepszy; Teresa Zak-Nejmark; R Koga; T Kobayashi; Kurt Blaser; Cezmi A. Akdis
Histamine regulates T-cell and antibody responses by differential expression of H1 and H2 receptors.
Nature 2001;413(6854):420-5.
2001: Cezmi A. Akdis; Kurt Blaser
Role of IL-10 in allergen-specific immunotherapy and normal response to allergens.
Microbes and infection / Institut Pasteur 2001;3(11):891-8.
2001: Peter Schmid-Grendelmeier; D Simon; H U Simon; Cezmi A. Akdis; Brunello Wüthrich
Epidemiology, clinical features, and immunology of the "intrinsic" (non-IgE-mediated) type of atopic dermatitis (constitutional dermatitis).
Allergy 2001;56(9):841-9.
2001: Susanne Vrtala; Kora Hirtenlehner; Markus Susani; Mübeccel Akdis; Fatimah Kussebi; Cezmi A. Akdis; Kurt Blaser; Peter Hufnagl; Bernd R Binder; A Politou; A Pastore; Luca Vangelista; Wolfgang R Sperr; Hans Semper; Peter Valent; Christof Ebner; Dietrich Kraft; Rudolf Valenta
Genetic engineering of a hypoallergenic trimer of the major birch pollen allergen Bet v 1.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2001;15(11):2045-7.
2001: Mübeccel Akdis; Axel Trautmann; Sven Klunker; Kurt Blaser; Cezmi A. Akdis
Cytokine network and dysregulated apoptosis in atopic dermatitis.
Acta odontologica Scandinavica 2001;59(3):178-82.
2001: Cezmi A. Akdis; Kurt Blaser
Mechanisms of interleukin-10-mediated immune suppression.
Immunology 2001;103(2):131-6.
2001: Cezmi A. Akdis; Kurt Blaser
[Principles of specific immunotherapy of IgE-induced allergic reactions].
Therapeutische Umschau. Revue thérapeutique 2001;58(5):274-7.
2001: Cezmi A. Akdis; K Blaser
Bypassing IgE and targeting T cells for specific immunotherapy of allergy.
Trends in immunology 2001;22(4):175-8.
2001: Cezmi A. Akdis; Kurt Blaser
Immunologic mechanisms of allergen-specific immunotherapy.
Advances in experimental medicine and biology 2001;495():247-59.
2001: Axel Trautmann; Mübeccel Akdis; Sven Klunker; Kurt Blaser; Cezmi A. Akdis
Role of apoptosis in atopic dermatitis.
International archives of allergy and immunology 2001;124(1-3):230-2.
2001: Marek Jutel; Sven Klunker; Mübeccel Akdis; J Małolepszy; Olivier Thomet; Teresa Zak-Nejmark; Kurt Blaser; Cezmi A. Akdis
Histamine upregulates Th1 and downregulates Th2 responses due to different patterns of surface histamine 1 and 2 receptor expression.
International archives of allergy and immunology 2001;124(1-3):190-2.
2001: Cezmi A. Akdis; Andrea Joss; Mübeccel Akdis; Kurt Blaser
Mechanism of IL-10-induced T cell inactivation in allergic inflammation and normal response to allergens.
International archives of allergy and immunology 2001;124(1-3):180-2.
2000: Cezmi A. Akdis; Mübeccel Akdis; A Trautmann; Kurt Blaser
Immune regulation in atopic dermatitis.
Current opinion in immunology 2000;12(6):641-6.
2000: Mübeccel Akdis; Sven Klunker; M Schliz; Kurt Blaser; Cezmi A. Akdis
Expression of cutaneous lymphocyte-associated antigen on human CD4(+) and CD8(+) Th2 cells.
European journal of immunology 2000;30(12):3533-41.
2000: Susanne Vrtala; Cezmi A. Akdis; F Budak; Mübeccel Akdis; Kurt Blaser; Dietrich Kraft; Rudolf Valenta
T cell epitope-containing hypoallergenic recombinant fragments of the major birch pollen allergen, Bet v 1, induce blocking antibodies.
Journal of immunology (Baltimore, Md. : 1950) 2000;165(11):6653-9.
2000: A Trautmann; M Akdis; K Blaser; Cezmi A. Akdis
Role of dysregulated apoptosis in atopic dermatitis.
Apoptosis : an international journal on programmed cell death 2000;5(5):425-9.
2000: Cezmi A. Akdis; Andrea Joss; Mübeccel Akdis; A Faith; Kurt Blaser
A molecular basis for T cell suppression by IL-10: CD28-associated IL-10 receptor inhibits CD28 tyrosine phosphorylation and phosphatidylinositol 3-kinase binding.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2000;14(12):1666-8.
2000: Axel Trautmann; Mübeccel Akdis; D Kleemann; F Altznauer; Hans-Uwe Simon; T Graeve; M Noll; Eva-B Bröcker; Kurt Blaser; Cezmi A. Akdis
T cell-mediated Fas-induced keratinocyte apoptosis plays a key pathogenetic role in eczematous dermatitis.
The Journal of clinical investigation 2000;106(1):25-35.
2000: Andrea Joss; Mübeccel Akdis; A Faith; Kurt Blaser; Cezmi A. Akdis
IL-10 directly acts on T cells by specifically altering the CD28 co-stimulation pathway.
European journal of immunology 2000;30(6):1683-90.
2000: Cezmi A. Akdis; Kurt Blaser
Mechanisms of allergen-specific immunotherapy.
Allergy 2000;55(6):522-30.
2000: Cezmi A. Akdis; Kurt Blaser
Regulation of specific immune responses by chemical and structural modifications of allergens.
International archives of allergy and immunology 2000;121(4):261-9.
2000: Haluk B Oral; Cezmi A. Akdis
Antibody-based therapies in infectious diseases.
Methods in molecular medicine 2000;40():157-78.
1999: Cezmi A. Akdis; Mübeccel Akdis; D Simon; B Dibbert; M Weber; S Gratzl; O Kreyden; Rainer Disch; Brunello Wüthrich; Kurt Blaser; Hans-Uwe Simon
T cells and T cell-derived cytokines as pathogenic factors in the nonallergic form of atopic dermatitis.
The Journal of investigative dermatology 1999;113(4):628-34.
1999: Mübeccel Akdis; Hans-Uwe Simon; L Weigl; O Kreyden; Kurt Blaser; Cezmi A. Akdis
Skin homing (cutaneous lymphocyte-associated antigen-positive) CD8+ T cells respond to superantigen and contribute to eosinophilia and IgE production in atopic dermatitis.
Journal of immunology (Baltimore, Md. : 1950) 1999;163(1):466-75.
1999: Cezmi A. Akdis; Kurt Blaser
IL-10-induced anergy in peripheral T cell and reactivation by microenvironmental cytokines: two key steps in specific immunotherapy.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1999;13(6):603-9.
1999: Cezmi A. Akdis; Mübeccel Akdis; Hans-Uwe Simon; Kurt Blaser
Regulation of allergic inflammation by skin-homing T cells in allergic eczema.
International archives of allergy and immunology 1999;118(2-4):140-4.
1999: A Faith; Cezmi A. Akdis; Mübeccel Akdis; Andrea Joss; D Wymann; Kurt Blaser
An altered peptide ligand specifically inhibits Th2 cytokine synthesis by abrogating TCR signaling.
Journal of immunology (Baltimore, Md. : 1950) 1999;162(3):1836-42.
1999: K Blaser; Cezmi A. Akdis; A Faith
Differential regulation of allergen-specific antibodies in allergy and specific immunotherapy.
Arbeiten aus dem Paul-Ehrlich-Institut (Bundesamt für Sera und Impfstoffe) zu Frankfurt a.M 1999;(93):243-51; discussion 252.
1999: Cezmi A. Akdis; K Blaser
Immunologic mechanisms of specific immunotherapy.
Allergy 1999;54 Suppl 56():31-2.
1999: Cezmi A. Akdis; Mübeccel Akdis; D Simon; B Dibbert; M Weber; S Gratzl; O Kreyden; Rainer Disch; Brunello Wüthrich; Kurt Blaser; Hans-Uwe Simon
Role of T cells and cytokines in the intrinsic form of atopic dermatitis.
Current problems in dermatology 1999;28():37-44.
1999: D Wymann; M Blüggel; Hubert Kalbacher; T Blesken; Cezmi A. Akdis; H E Meyer; Kurt Blaser
Human B cells secrete migration inhibition factor (MIF) and present a naturally processed MIF peptide on HLA-DRB1*0405 by a FXXL motif.
Immunology 1999;96(1):1-9.
1998: Kurt Blaser; José M Carballido; A Faith; Reto Crameri; Cezmi A. Akdis
Determinants and mechanisms of human immune responses to bee venom phospholipase A2.
International archives of allergy and immunology 1998;117(1):1-10.
1998: D Wymann; Cezmi A. Akdis; T Blesken; Mübeccel Akdis; Reto Crameri; Kurt Blaser
Enzymatic activity of soluble phospholipase A2 does not affect the specific IgE, IgG4 and cytokine responses in bee sting allergy.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 1998;28(7):839-49.
1998: Cezmi A. Akdis; T Blesken; Mübeccel Akdis; Brunello Wüthrich; Kurt Blaser
Role of interleukin 10 in specific immunotherapy.
The Journal of clinical investigation 1998;102(1):98-106.
1998: U Müller; Cezmi A. Akdis; M Fricker; Mübeccel Akdis; T Blesken; F Bettens; Kurt Blaser
Successful immunotherapy with T-cell epitope peptides of bee venom phospholipase A2 induces specific T-cell anergy in patients allergic to bee venom.
The Journal of allergy and clinical immunology 1998;101(6 Pt 1):747-54.
1998: Cezmi A. Akdis; T Blesken; D Wymann; Mübeccel Akdis; Kurt Blaser
Differential regulation of human T cell cytokine patterns and IgE and IgG4 responses by conformational antigen variants.
European journal of immunology 1998;28(3):914-25.
1997: Mübeccel Akdis; Cezmi A. Akdis; L Weigl; Rainer Disch; Kurt Blaser
Skin-homing, CLA+ memory T cells are activated in atopic dermatitis and regulate IgE by an IL-13-dominated cytokine pattern: IgG4 counter-regulation by CLA- memory T cells.
Journal of immunology (Baltimore, Md. : 1950) 1997;159(9):4611-9.
1997: Cezmi A. Akdis; T Blesken; Mübeccel Akdis; Sefik Alkan; C H Heusser; Kurt Blaser
Glucocorticoids inhibit human antigen-specific and enhance total IgE and IgG4 production due to differential effects on T and B cells in vitro.
European journal of immunology 1997;27(9):2351-7.
1997: A Faith; Cezmi A. Akdis; Mübeccel Akdis; Hans-Uwe Simon; Kurt Blaser
Defective TCR stimulation in anergized type 2 T helper cells correlates with abrogated p56(lck) and ZAP-70 tyrosine kinase activities.
Journal of immunology (Baltimore, Md. : 1950) 1997;159(1):53-60.
1997: Cezmi A. Akdis; T Blesken; Mübeccel Akdis; Sefik Alkan; Brunello Wüthrich; C H Heusser; Kurt Blaser
Induction and differential regulation of bee venom phospholipase A2-specific human IgE and IgG4 antibodies in vitro requires allergen-specific and nonspecific activation of T and B cells.
The Journal of allergy and clinical immunology 1997;99(3):345-53.
1997: A G Oehling; Cezmi A. Akdis; Andreas Schapowal; Kurt Blaser; M Schmitz; Hans-Uwe Simon
Suppression of the immune system by oral glucocorticoid therapy in bronchial asthma.
Allergy 1997;52(2):144-54.
1996: Cezmi A. Akdis; Mübeccel Akdis; T Blesken; D Wymann; Sefik Alkan; U Müller; Kurt Blaser
Epitope-specific T cell tolerance to phospholipase A2 in bee venom immunotherapy and recovery by IL-2 and IL-15 in vitro.
The Journal of clinical investigation 1996;98(7):1676-83.
1994: S Alkan; Cezmi A. Akdis; H Towbin
Chemiluminescent and enzyme-linked immuno assays for sensitive detection of human IFN-gamma.
Journal of immunoassay 1994;15(3):217-38.