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Miguel Medina

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Alzheimer's Disease

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Edward J Caterson; Joseph Lopez; Miguel Medina; Bohdan Pomahac; Stefan G Tullius
Ischemia-reperfusion injury in vascularized composite allotransplantation.
Teodoro del Ser; David Fleet; Hermann J Gertz; Belén Gómez-Carrillo; Miguel Medina; Pilar Redondo; Klaus C Steinwachs; Joan A Vericat; María V Andrés; Teresa León
Treatment of Alzheimer's disease with the GSK-3 inhibitor tideglusib: a pilot study.
Michael Maes; Miguel Medina; Gabriel Nowak; Giovanni Scapagnini; Zdenĕk Fišar; Michael Berk
New drug targets in depression: inflammatory, cell-mediated immune, oxidative and nitrosative stress, mitochondrial, antioxidant, and neuroprogressive pathways. And new drug candidates--Nrf2 activators and GSK-3 inhibitors.

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All Publications

2013: Edward J Caterson; Joseph Lopez; Miguel Medina; Bohdan Pomahac; Stefan G Tullius
Ischemia-reperfusion injury in vascularized composite allotransplantation.
The Journal of craniofacial surgery 2013;24(1):51-6.
2013: Teodoro del Ser; David Fleet; Hermann J Gertz; Belén Gómez-Carrillo; Miguel Medina; Pilar Redondo; Klaus C Steinwachs; Joan A Vericat; María V Andrés; Teresa León
Treatment of Alzheimer's disease with the GSK-3 inhibitor tideglusib: a pilot study.
Journal of Alzheimer's disease : JAD 2013;33(1):205-15.
2012: Michael Maes; Miguel Medina; Gabriel Nowak; Giovanni Scapagnini; Zdenĕk Fišar; Michael Berk
New drug targets in depression: inflammatory, cell-mediated immune, oxidative and nitrosative stress, mitochondrial, antioxidant, and neuroprogressive pathways. And new drug candidates--Nrf2 activators and GSK-3 inhibitors.
Inflammopharmacology 2012;20(3):127-50.
2012: Juan Manuel Domínguez; María del Monte-Millán; Elena Delgado; Ana Fuertes; Leyre Orozco; Miguel Medina
Evidence for irreversible inhibition of glycogen synthase kinase-3β by tideglusib.
The Journal of biological chemistry 2012;287(2):893-904.
2011: D Simon; Miguel Medina; Jesús Avila; Francisco Wandosell
Overcoming cell death and tau phosphorylation mediated by PI3K-inhibition: a cell assay to measure neuroprotection.
CNS & neurological disorders drug targets 2011;10(2):208-14.
2011: Miguel Medina; Juan Jose Garrido; Francisco G Wandosell
Modulation of GSK-3 as a Therapeutic Strategy on Tau Pathologies.
Frontiers in molecular neuroscience 2011;4():24.
2011: Miguel Medina; Francisco Wandosell
Deconstructing GSK-3: The Fine Regulation of Its Activity.
International journal of Alzheimer's disease 2011;2011():479249.
2010: Miguel Medina; Jesús Avila
Glycogen synthase kinase-3 (GSK-3) inhibitors for the treatment of Alzheimer's disease.
Current pharmaceutical design 2010;16(25):2790-8.
2008: Kawther Abu-Elneel; Tomoyo Ochiishi; Miguel Medina; Monica Remedi; Laura Gastaldi; Alfredo Caceres; Kenneth S Kosik
A delta-catenin signaling pathway leading to dendritic protrusions.
The Journal of biological chemistry 2008;283(47):32781-91.
2008: Angelo Rosa; Manuella P Kaster; Ricardo W Binfaré; Susana Morales; Ester Martin-Aparicio; Maria Luisa Navarro-Rico; Ana Martinez; Miguel Medina; Antonio G García; Manuela G López; Ana Lúcia S Rodrigues
Antidepressant-like effect of the novel thiadiazolidinone NP031115 in mice.
Progress in neuro-psychopharmacology & biological psychiatry 2008;32(6):1549-56.
2008: Miguel Medina; Ana Castro
Glycogen synthase kinase-3 (GSK-3) inhibitors reach the clinic.
Current opinion in drug discovery & development 2008;11(4):533-43.
2008: E García-Palomero; P Muñoz; P Usan; P Garcia; E Delgado; C De Austria; R Valenzuela; L Rubio; Miguel Medina; A Martínez
Potent beta-amyloid modulators.
Neuro-degenerative diseases 2008;5(3-4):153-6.
2007: Mark Hamann; Diana Alonso; Ester Martin-Aparicio; Ana Fuertes; M José Pérez-Puerto; Ana Castro; Susana Morales; María Luisa Navarro; María del Monte-Millán; Miguel Medina; Hari Pennaka; Akula Balaiah; Jiangnan Peng; Jennifer Cook; Subagus Wahyuono; Ana Martínez
Glycogen synthase kinase-3 (GSK-3) inhibitory activity and structure-activity relationship (SAR) studies of the manzamine alkaloids. Potential for Alzheimer's disease.
Journal of natural products 2007;70(9):1397-405.
2006: Karumanchi V Rao; Marwa Donia; Jiangnan Peng; Esther Garcia-Palomero; Diana Alonso; Ana Martinez; Miguel Medina; Scott Franzblau; Babu L Tekwani; Shabana I Khan; Subagus Wahyuono; Kristine L Willett; Mark T Hamann
Manzamine B and E and ircinal A related alkaloids from an Indonesian Acanthostrongylophora sponge and their activity against infectious, tropical parasitic, and Alzheimer's diseases.
Journal of natural products 2006;69(7):1034-40.
2006: María del Monte-Millán; Esther García-Palomero; Rita Valenzuela; Paola Usán; Celia de Austria; Pilar Muñoz-Ruiz; Laura Rubio; Isabel Dorronsoro; Ana Martínez; Miguel Medina
Dual binding site acetylcholinesterase inhibitors: potential new disease-modifying agents for AD.
Journal of molecular neuroscience : MN 2006;30(1-2):85-8.
2005: D Alonso; Isabel Dorronsoro; Laura Rubio; P Muñoz; Esther García-Palomero; M Del Monte; Axel Bidon-Chanal; Modesto Orozco; F Javier Luque; Ana Castro; Miguel Medina; Ana Martínez
Donepezil-tacrine hybrid related derivatives as new dual binding site inhibitors of AChE.
Bioorganic & medicinal chemistry 2005;13(24):6588-97.
2005: Pilar Muñoz-Ruiz; Laura Rubio; Esther García-Palomero; Isabel Dorronsoro; María del Monte-Millán; Rita Valenzuela; Paola Usán; Celia de Austria; Manuela Bartolini; Vincenza Andrisano; Axel Bidon-Chanal; Modesto Orozco; F Javier Luque; Miguel Medina; Ana Martínez
Design, synthesis, and biological evaluation of dual binding site acetylcholinesterase inhibitors: new disease-modifying agents for Alzheimer's disease.
Journal of medicinal chemistry 2005;48(23):7223-33.
2005: Manel G Medina; Maria Dolores Ledesma; Jorge E Domínguez; Miguel Medina; Delia Zafra; Francesc Alameda; Carlos G Dotti; Pilar Navarro
Tissue plasminogen activator mediates amyloid-induced neurotoxicity via Erk1/2 activation.
The EMBO journal 2005;24(9):1706-16.
2004: José Abad-Rodríguez; Maria Dolores Ledesma; Katleen Craessaerts; Simona Perga; Miguel Medina; André Delacourte; Colin Dingwall; Bart De Strooper; Carlos G Dotti
Neuronal membrane cholesterol loss enhances amyloid peptide generation.
The Journal of cell biology 2004;167(5):953-60.
2004: Peter J Morin; Miguel Medina; Mikhail Semenov; Anthony M C Brown; Kenneth S Kosik
Wnt-1 expression in PC12 cells induces exon 15 deletion and expression of L-APP.
Neurobiology of disease 2004;16(1):59-67.
2003: Jorge Santos da Silva; Miguel Medina; Cecilia Zuliani; Alessia Di Nardo; Walter Witke; Carlos G Dotti
RhoA/ROCK regulation of neuritogenesis via profilin IIa-mediated control of actin stability.
The Journal of cell biology 2003;162(7):1267-79.
2003: Miguel Medina; Carlos G Dotti
RIPped out by presenilin-dependent gamma-secretase.
Cellular signalling 2003;15(9):829-41.
2002: Joseph F Arboleda-Velasquez; Francisco Lopera; E Lopez; M P Frosch; D Sepulveda-Falla; J E Gutierrez; S Vargas; Miguel Medina; C Martinez De Arrieta; R V Lebo; S A Slaugenhaupt; Rebecca A Betensky; A Villegas; Mauricio Arcos-Burgos; Dora Rivera; J C Restrepo; Kenneth S Kosik
C455R notch3 mutation in a Colombian CADASIL kindred with early onset of stroke.
Neurology 2002;59(2):277-9.
2002: Michael G Schlossmacher; Matthew P Frosch; Wei Ping Gai; Miguel Medina; Nutan Sharma; Lysia Forno; Tomoyo Ochiishi; Hideki Shimura; Ronit Sharon; Nobutaka Hattori; J William Langston; Yoshikuni Mizuno; Bradley T Hyman; Dennis J Selkoe; Kenneth S Kosik
Parkin localizes to the Lewy bodies of Parkinson disease and dementia with Lewy bodies.
The American journal of pathology 2002;160(5):1655-67.
2002: Q Lu; Nishit K Mukhopadhyay; James D Griffin; M Paredes; Miguel Medina; Kenneth S Kosik
Brain armadillo protein delta-catenin interacts with Abl tyrosine kinase and modulates cellular morphogenesis in response to growth factors.
Journal of neuroscience research 2002;67(5):618-24.
2001: Narcisa Martinez-Quiles; R Rohatgi; Inés M Antón; Miguel Medina; Stephen P Saville; H Miki; H Yamaguchi; T Takenawa; John H Hartwig; Raif S Geha; Narayanaswamy Ramesh
WIP regulates N-WASP-mediated actin polymerization and filopodium formation.
Nature cell biology 2001;3(5):484-91.
2000: Elizabeth Noll; Miguel Medina; D Hartley; J Zhou; Norbert Perrimon; Kenneth S Kosik
Presenilin affects arm/beta-catenin localization and function in Drosophila.
Developmental biology 2000;227(2):450-64.
2000: C Ho; J Zhou; Miguel Medina; T Goto; M Jacobson; P G Bhide; Kenneth S Kosik
delta-catenin is a nervous system-specific adherens junction protein which undergoes dynamic relocalization during development.
The Journal of comparative neurology 2000;420(2):261-76.
2000: Miguel Medina; RC Marinescu; J Overhauser; Kenneth S Kosik
Hemizygosity of delta-catenin (CTNND2) is associated with severe mental retardation in cri-du-chat syndrome.
Genomics 2000;63(2):157-64.
1999: M Teresa Moreno-Flores; Miguel Medina; Francisco Wandosell
Expression of presenilin 1 in nervous system during rat development.
The Journal of comparative neurology 1999;410(4):556-70.
1999: Q Lu; M Paredes; Miguel Medina; J Zhou; R Cavallo; Mark Peifer; L Orecchio; Kenneth S Kosik
delta-catenin, an adhesive junction-associated protein which promotes cell scattering.
The Journal of cell biology 1999;144(3):519-32.
1997: J Zhou; U Liyanage; Miguel Medina; C Ho; AD Simmons; M Lovett; Kenneth S Kosik
Presenilin 1 interaction in the brain with a novel member of the Armadillo family.
Neuroreport 1997;8(8):2085-90.
1997: J Zhou; U Liyanage; Miguel Medina; C Ho; AD Simmons; M Lovett; Kenneth S Kosik
Presenilin 1 interaction in the brain with a novel member of the Armadillo family.
Neuroreport 1997;8(6):1489-94.
1996: M Pérez; José M Valpuesta; Miguel Medina; E Montejo de Garcini; Jesús Avila
Polymerization of tau into filaments in the presence of heparin: the minimal sequence required for tau-tau interaction.
Journal of neurochemistry 1996;67(3):1183-90.
1996: Miguel Medina; M García-Rocha; R Padilla; M Pérez; E Montejo de Garcini; Jesús Avila
Protein kinases involved in the phosphorylation of human tau protein in transfected COS-1 cells.
Biochimica et biophysica acta 1996;1316(1):43-50.
1996: M D Ledesma; Miguel Medina; Jesús Avila
The in vitro formation of recombinant tau polymers: effect of phosphorylation and glycation.
Molecular and chemical neuropathology / sponsored by the International Society for Neurochemistry and the World Federation of Neurology and research groups on neurochemistry and cerebrospinal fluid 1996;27(3):249-58.
1995: Francisco J Moreno; Miguel Medina; M Pérez; E Montejo de Garcini; Jesús Avila
Glycogen synthase kinase 3 phosphorylates recombinant human tau protein at serine-262 in the presence of heparin (or tubulin).
FEBS letters 1995;372(1):65-8.
1995: Miguel Medina; E Montejo de Garcini; Jesús Avila
The role of tau phosphorylation in transfected COS-1 cells.
Molecular and cellular biochemistry 1995;148(1):79-88.
1995: Miguel Medina; G J Belsham; E Domingo; A López-Rivas; D Zuidema; J M Vlak
Strong buffering capacity of insect cells. Implications for the baculovirus expression system.
Cytotechnology 1995;17(1):21-6.
1994: J González-Nicolás; Miguel Medina; Y Fermín; F Moreno; Jesús Avila
Identification of protein kinases that modify specific epitopes.
Analytical biochemistry 1994;223(1):159-61.
1994: Juan-Carlos Sáiz; J Cairó; Miguel Medina; Douwe Zuidema; C Abrams; G J Belsham; Esteban Domingo; Just M Vlak
Unprocessed foot-and-mouth disease virus capsid precursor displays discontinuous epitopes involved in viral neutralization.
Journal of virology 1994;68(7):4557-64.
1993: Miguel Medina; E Domingo; J K Brangwyn; G J Belsham
The two species of the foot-and-mouth disease virus leader protein, expressed individually, exhibit the same activities.
Virology 1993;194(1):355-9.
1993: C Smerdou; J M Torres; CP Sánchez; C Suñé; I M Antón; Miguel Medina; Joaquin Castilla; F L Graham; Luis Enjuanes
Induction of an immune response to transmissible gastroenteritis coronavirus using vectors with enteric tropism.
Advances in experimental medicine and biology 1993;342():455-62.
1992: Cristina Escarmís; M Toja; Miguel Medina; Esteban Domingo
Modifications of the 5' untranslated region of foot-and-mouth disease virus after prolonged persistence in cell culture.
Virus research 1992;26(2):113-25.
1989: Miguel Medina; Carmen G Vallejo
The contents of proteins, carbohydrates, lipids and DNA during the embryogenesis of Drosophila.
The International journal of developmental biology 1989;33(3):403-5.
1989: Miguel Medina; Carmen G Vallejo
An aspartic proteinase in Drosophila: maternal origin and yolk localization.
The International journal of developmental biology 1989;33(2):313-5.
1988: Miguel Medina; P León; Carmen G Vallejo
Drosophila cathepsin B-like proteinase: a suggested role in yolk degradation.
Archives of biochemistry and biophysics 1988;263(2):355-63.