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Christine Beeton

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Michael Pennington; Rajeev B Tajhya; Christine Beeton; M Harunur Rashid; Serdar Kuyucak; Raymond S Norton
A C-terminally amidated analogue of ShK is a potent and selective blocker of the voltage-gated potassium channel Kv1.3.
Shih Chieh Chang; Charles Galea; Eleanor W W Leung; Michael Pennington; Rajeev B Tajhya; Christine Beeton; Raymond S Norton
Expression and isotopic labelling of the potassium channel blocker ShK toxin as a thioredoxin fusion protein in bacteria.
Eric J Tarcha; Indra Tjong; Sanjeev K Upadhyay; David Bailey; Amy Banks; Christine Beeton; Scott E Boley; K George Chandy; Victor Chi; Zachary Hansen; Xueyou Hu; Dustin Kentala; Brian Knapp; Luz M Londono; Ernesto J Muñoz-Elías; Hai Nguyen; Kayla Norton; Michael Pennington; Greg W Ruppert; James Sams; Richard Slauter; Shawn P Iadonato
Durable pharmacological responses from the peptide ShK-186, a specific Kv1.3 channel inhibitor that suppresses T cell mediators of autoimmune disease.

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All Publications

2012: Michael Pennington; Rajeev B Tajhya; Christine Beeton; M Harunur Rashid; Serdar Kuyucak; Raymond S Norton
A C-terminally amidated analogue of ShK is a potent and selective blocker of the voltage-gated potassium channel Kv1.3.
FEBS letters 2012;586(22):3996-4001.
2012: Shih Chieh Chang; Charles Galea; Eleanor W W Leung; Michael Pennington; Rajeev B Tajhya; Christine Beeton; Raymond S Norton
Expression and isotopic labelling of the potassium channel blocker ShK toxin as a thioredoxin fusion protein in bacteria.
Toxicon : official journal of the International Society on Toxinology 2012;60(5):840-50.
2012: Eric J Tarcha; Indra Tjong; Sanjeev K Upadhyay; David Bailey; Amy Banks; Christine Beeton; Scott E Boley; K George Chandy; Victor Chi; Zachary Hansen; Xueyou Hu; Dustin Kentala; Brian Knapp; Luz M Londono; Ernesto J Muñoz-Elías; Hai Nguyen; Kayla Norton; Michael Pennington; Greg W Ruppert; James Sams; Richard Slauter; Shawn P Iadonato
Durable pharmacological responses from the peptide ShK-186, a specific Kv1.3 channel inhibitor that suppresses T cell mediators of autoimmune disease.
The Journal of pharmacology and experimental therapeutics 2012;342(3):642-53.
2012: Zoltan Varga; Christine Beeton; Luis Cardenas; Rezso Gaspar; Georgina Gurrola-Briones; Ferenc Papp; Gustavo Pedraza-Alva; Lourival D Possani; Ricardo C Rodríguez de la Vega; Yvonne Rosenstein; Rajeev B Tajhya; György Panyi
Vm24, a natural immunosuppressive peptide, potently and selectively blocks Kv1.3 potassium channels of human T cells.
Molecular pharmacology 2012;82(3):372-82.
2012: Victor Chi; Shawn Iadonato; Jonathan T Lakey; Luz M Londono; Raymond S Norton; Michael Pennington; Brian Sims-Fahey; Eric J Tarcha; Sanjeev K Upadhyay; Heike Wulff; Christine Beeton; K George Chandy
Development of a sea anemone toxin as an immunomodulator for therapy of autoimmune diseases.
Toxicon : official journal of the International Society on Toxinology 2012;59(4):529-46.
2012: Xueyou Hu; Iskander I Ismailov; Karlie R Jones; Shyny Koshy; teresina laragione; Liang Sun; Patricia Yotnda; Pércio S Gulko; Frank T Horrigan; Christine Beeton
KCa1.1 potassium channels regulate key proinflammatory and invasive properties of fibroblast-like synoviocytes in rheumatoid arthritis.
The Journal of biological chemistry 2012;287(6):4014-22.
2012: Raveendra Anangi; Christine Beeton; Woei-Jer Chuang; Redwan Huq; Shyny Koshy; Glenn F King
Recombinant expression of margatoxin and agitoxin-2 in Pichia pastoris: an efficient method for production of KV1.3 channel blockers.
PloS one 2012;7(12):e52965.
2011: Christine Beeton; Michael Pennington; Raymond S Norton
Analogs of the sea anemone potassium channel blocker ShK for the treatment of autoimmune diseases.
Inflammation & allergy drug targets 2011;10(5):313-21.
2011: Haik Mkhikian; Ani Grigorian; Carey F Li; Hung-Lin Chen; Barbara Newton; Raymond W Zhou; Christine Beeton; Sevan Torossian; Gevork Grikor Tatarian; Sung-Uk Lee; Ken Lau; Erin Walker; Katherine A Siminovitch; K George Chandy; Zhaoxia Yu; James W Dennis; Michael Demetriou
Genetics and the environment converge to dysregulate N-glycosylation in multiple sclerosis.
Nature communications 2011;2():334.
2010: Xueyou Hu; Christine Beeton
Detection of functional matrix metalloproteinases by zymography.
Journal of visualized experiments : JoVE 2010;(45):.
2010: Shyny Koshy; Parema Alizadeh; Lubov T Timchenko; Christine Beeton
Quantitative measurement of GLUT4 translocation to the plasma membrane by flow cytometry.
Journal of visualized experiments : JoVE 2010;(45):.
2009: Michael Pennington; Christine Beeton; Charles Galea; B J Smith; V Chi; K P Monaghan; A Garcia; srikant rangaraju; A Giuffrida; D Plank; G Crossley; D Nugent; I Khaytin; Y Lefievre; I Peshenko; C Dixon; S Chauhan; A Orzel; T Inoue; X Hu; R V Moore; R S Norton; K G Chandy
Engineering a stable and selective peptide blocker of the Kv1.3 channel in T lymphocytes.
Molecular pharmacology 2009;75(4):762-73.
2008: Melanie P Matheu; Christine Beeton; Adriana Garcia; Victor Chi; srikant rangaraju; Olga Safrina; Kevin Monaghan; Marc I Uemura; Dan Li; Sukumar Pal; Luis M de la Maza; Edwin Monuki; Alexander Flügel; Michael Pennington; Ian Parker; K George Chandy; Michael D Cahalan
Imaging of effector memory T cells during a delayed-type hypersensitivity reaction and suppression by Kv1.3 channel block.
Immunity 2008;29(4):602-14.
2008: Christine Beeton; Brian J Smith; Jennifer K Sabo; George Crossley; Daniel Nugent; Ilya Khaytin; Victor Chi; K George Chandy; Michael Pennington; Raymond S Norton
The D-diastereomer of ShK toxin selectively blocks voltage-gated K+ channels and inhibits T lymphocyte proliferation.
The Journal of biological chemistry 2008;283(2):988-97.
2008: Melanie P Matheu; Christine Beeton; Ian Parker; K George Chandy; Michael D Cahalan
Imaging effector memory T cells in the ear after induction of adoptive DTH.
Journal of visualized experiments : JoVE 2008;(18):.
2007: Christine Beeton
Discovery on Target 2007--CHI's Fifth Annual Conference. Ion channels.
IDrugs : the investigational drugs journal 2007;10(12):851-4.
2007: Christine Beeton; K George Chandy
Induction and monitoring of adoptive delayed-type hypersensitivity in rats.
Journal of visualized experiments : JoVE 2007;(8):.
2007: Christine Beeton; K George Chandy
Induction and monitoring of active delayed type hypersensitivity (DTH) in rats.
Journal of visualized experiments : JoVE 2007;(6):237.
2007: Christine Beeton; Adriana Garcia; K George Chandy
Drawing blood from rats through the saphenous vein and by cardiac puncture.
Journal of visualized experiments : JoVE 2007;(7):266.
2007: Christine Beeton; K George Chandy
Enrichment of NK cells from human blood with the RosetteSep kit from StemCell technologies.
Journal of visualized experiments : JoVE 2007;(8):326.
2007: Christine Beeton; K George Chandy
Isolation of mononuclear cells from the central nervous system of rats with EAE.
Journal of visualized experiments : JoVE 2007;(10):527.
2007: Christine Beeton; K George Chandy
Preparing T cell growth factor from rat splenocytes.
Journal of visualized experiments : JoVE 2007;(10):402.
2007: Christine Beeton; Adriana Garcia; K George Chandy
Induction and clinical scoring of chronic-relapsing experimental autoimmune encephalomyelitis.
Journal of visualized experiments : JoVE 2007;(5):224.
2006: Christine Beeton; Heike Wulff; Nathan E Standifer; Philippe Azam; Katherine M Mullen; Michael Pennington; Aaron Kolski-Andreaco; Eric Wei; Alexandra Grino; Debra R Counts; Ping H Wang; Christine J LeeHealey; Brian S Andrews; Ananthakrishnan Sankaranarayanan; Daniel Homerick; Werner W Roeck; Jamshid Tehranzadeh; Kimber L Stanhope; Pavel Zimin; Peter J Havel; Stephen M Griffey; Hans-Günther Knaus; Gerald Nepom; George A Gutman; Peter A Calabresi; K George Chandy
Kv1.3 channels are a therapeutic target for T cell-mediated autoimmune diseases.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(46):17414-9.
2005: Christine Beeton; K George Chandy
Potassium channels, memory T cells, and multiple sclerosis.
The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry 2005;11(6):550-62.
2005: Louis Carrega; Amor Mosbah; Gilles Ferrat; Christine Beeton; nicolas andreotti; Pascal Mansuelle; Hervé Darbon; Michel De Waard; Jean-Marc Sabatier
The impact of the fourth disulfide bridge in scorpion toxins of the alpha-KTx6 subfamily.
Proteins 2005;61(4):1010-23.
2005: Horea Rus; CARLOS PARDO-VILLAMIZAR; Lina Hu; Erika Darrah; Cornelia Cudrici; Teodora Niculescu; Florin Niculescu; Katherine M Mullen; Rameeza Allie; Liping Guo; Heike Wulff; Christine Beeton; Susan I V Judge; Douglas A Kerr; Hans-Günther Knaus; K George Chandy; Peter A Calabresi
The voltage-gated potassium channel Kv1.3 is highly expressed on inflammatory infiltrates in multiple sclerosis brain.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(31):11094-9.
2005: Christine Beeton; Michael Pennington; Heike Wulff; Satendra Singh; Daniel Nugent; George Crossley; Ilya Khaytin; Peter A Calabresi; Chao Chen; George A Gutman; K George Chandy
Targeting effector memory T cells with a selective peptide inhibitor of Kv1.3 channels for therapy of autoimmune diseases.
Molecular pharmacology 2005;67(4):1369-81.
2004: Imed Regaya; Christine Beeton; Gilles Ferrat; nicolas andreotti; Hervé Darbon; Michel De Waard; Jean-Marc Sabatier
Evidence for domain-specific recognition of SK and Kv channels by MTX and HsTx1 scorpion toxins.
The Journal of biological chemistry 2004;279(53):55690-6.
2004: Julia Vennekamp; Heike Wulff; Christine Beeton; Peter A Calabresi; Stephan Grissmer; Wolfram Hänsel; K George Chandy
Kv1.3-blocking 5-phenylalkoxypsoralens: a new class of immunomodulators.
Molecular pharmacology 2004;65(6):1364-74.
2004: Jérôme J Devaux; Christine Beeton; Evelyne Béraud; Marcel Crest
[Ion channels and demyelination: basis of a treatment of experimental autoimmune encephalomyelitis (EAE) by potassium channel blockers].
Revue neurologique 2004;160(5 Pt 2):S16-27.
2004: K George Chandy; Heike Wulff; Christine Beeton; Michael Pennington; George A Gutman; Michael D Cahalan
K+ channels as targets for specific immunomodulation.
Trends in pharmacological sciences 2004;25(5):280-9.
2003: Heike Wulff; Christine Beeton; K George Chandy
Potassium channels as therapeutic targets for autoimmune disorders.
Current opinion in drug discovery & development 2003;6(5):640-7.
2003: Heike Wulff; Peter A Calabresi; Rameeza Allie; Sung Yun; Michael Pennington; Christine Beeton; K George Chandy
The voltage-gated Kv1.3 K(+) channel in effector memory T cells as new target for MS.
The Journal of clinical investigation 2003;111(11):1703-13.
2003: Christine Beeton; Heike Wulff; Satendra Singh; Steve Botsko; George Crossley; George A Gutman; Michael D Cahalan; Michael Pennington; K George Chandy
A novel fluorescent toxin to detect and investigate Kv1.3 channel up-regulation in chronically activated T lymphocytes.
The Journal of biological chemistry 2003;278(11):9928-37.
2003: Jérôme J Devaux; Claude Forni; Christine Beeton; Jocelyne Barbaria; Evelyne Béraud; Maurice Gola; Marcel Crest
Myelin basic protein-reactive T cells induce conduction failure in vivo but not in vitro.
Neuroreport 2003;14(3):317-20.
2001: Christine Beeton; Heike Wulff; Jocelyne Barbaria; O Clot-Faybesse; Michael Pennington; Dominique Bernard; Michael D Cahalan; K George Chandy; Evelyne Béraud
Selective blockade of T lymphocyte K(+) channels ameliorates experimental autoimmune encephalomyelitis, a model for multiple sclerosis.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(24):13942-7.
2001: Christine Beeton; Jocelyne Barbaria; Pierre Giraud; Jérôme J Devaux; A M Benoliel; Maurice Gola; Jean-Marc Sabatier; Dominique Bernard; Marcel Crest; Evelyne Béraud
Selective blocking of voltage-gated K+ channels improves experimental autoimmune encephalomyelitis and inhibits T cell activation.
Journal of immunology (Baltimore, Md. : 1950) 2001;166(2):936-44.