FIND

researchers

DISCOVER

relevant articles

PROMOTE

your research

now for free

Charles Chalfant

Research Profile

Chemicals & Drugs

Physiology

Anatomy

Living Beings

Rats

Co-author Network

Publications

TOP 3
Ngoc T Vu; Rachel W Goehe; L Alexis Hoeferlin; Kristen W Lynch; Margaret A Park; Jacqueline C Shultz; Michael D Shultz; Sarah A Smith; Charles E Chalfant
hnRNP U enhances caspase-9 splicing and is modulated by AKT-dependent phosphorylation of hnRNP L.
Katherine E Ward; Mohsin Vora; Nitin Bhardwaj; Charles E Chalfant; Hui Lu; Robert V Stahelin
The molecular basis of ceramide-1-phosphate recognition by C2 domains.
L Alexis Hoeferlin; Dayanjan S Wijesinghe; Charles E Chalfant
The role of ceramide-1-phosphate in biological functions.

Register for free to view:

Visualized networks:

See your personal network in
sophisticated graphical views

GeoTargeted Searches:

Locate experts around the world
and connect with global collaborators

Research Profiles:

See the research activity
of experts around the globe

Geonetwork of Charles Chalfant (preview)

Cities where this author has publications
Cities where co-authors of this author have publications

Flash Player Required

All Publications

2013: Ngoc T Vu; Rachel W Goehe; L Alexis Hoeferlin; Kristen W Lynch; Margaret A Park; Jacqueline C Shultz; Michael D Shultz; Sarah A Smith; Charles E Chalfant
hnRNP U enhances caspase-9 splicing and is modulated by AKT-dependent phosphorylation of hnRNP L.
The Journal of biological chemistry 2013;288(12):8575-84.
2013: Katherine E Ward; Mohsin Vora; Nitin Bhardwaj; Charles E Chalfant; Hui Lu; Robert V Stahelin
The molecular basis of ceramide-1-phosphate recognition by C2 domains.
Journal of lipid research 2013;54(3):636-48.
2013: L Alexis Hoeferlin; Dayanjan S Wijesinghe; Charles E Chalfant
The role of ceramide-1-phosphate in biological functions.
Handbook of experimental pharmacology 2013;215():153-66.
2013: Jose Gomez-Arroyo; Donatas Kraskauskas; Edward J Lesnefsky; Shiro Mizuno; Ramesh Natarajan; Karol Szczepanek; Benjamin Van Tassell; Antonio Abbate; John Bigbee; Harm J Bogaard; Charles E Chalfant; Cristobal G dos Remedios; Jennifer I Drake; Laszlo Farkas; Dayanjan S Wijesinghe; Norbert F Voelkel
Metabolic gene remodeling and mitochondrial dysfunction in failing right ventricular hypertrophy secondary to pulmonary arterial hypertension.
Circulation. Heart failure 2013;6(1):136-44.
2012: John D Wilson; William C Broaddus; Charles E Chalfant; Harry C Dorn; Panos P Fatouros; Michael D Shultz
Metallofullerene-nanoplatform-delivered interstitial brachytherapy improved survival in a murine model of glioblastoma multiforme.
Bioconjugate chemistry 2012;23(9):1873-80.
2012: Sarah K Norton; Jamie Sturgill; Dayanjan S Wijesinghe; Zhiguo Zhou; Suzanne Barbour; Charles E Chalfant; Daniel H Conrad; Anthony Dellinger; Christopher L Kepley
Epoxyeicosatrienoic acids are involved in the C(70) fullerene derivative-induced control of allergic asthma.
The Journal of allergy and clinical immunology 2012;130(3):761-769.e2.
2012: Jacqueline C Shultz; Michael D Shultz; Ngoc Vu; Mba-Uzoma U Mba; Brian A Shapiro; Charles E Chalfant
The Proto-oncogene PKCι regulates the alternative splicing of Bcl-x pre-mRNA.
Molecular cancer research : MCR 2012;10(5):660-9.
2011: Jacqueline C Shultz; Dayanjan S Wijesinghe; Rachel W Goehe; Amy J Hawkins; Autumn Massiello; Eric K Mayton; Prabhat Mukerjee; Charuta S Murudkar; Margaret A Park; Ryan L Pinkerman; Charles E Chalfant
SRSF1 regulates the alternative splicing of caspase 9 via a novel intronic splicing enhancer affecting the chemotherapeutic sensitivity of non-small cell lung cancer cells.
Molecular cancer research : MCR 2011;9(7):889-900.
2011: Jacqueline C Shultz; Charles E Chalfant
Caspase 9b: a new target for therapy in non-small-cell lung cancer.
Expert review of anticancer therapy 2011;11(4):499-502.
2011: Meir Goldsmith; Ala Daka; Nadia F Lamour; Roy Mashiach; Yifat Glucksam; Michael M Meijler; Charles E Chalfant; Tsaffrir Zor
A ceramide analog inhibits cPLA(2) activity and consequent PGE(2) formation in LPS-stimulated macrophages.
Immunology letters 2011;135(1-2):136-43.
2011: Léon J A Spijkers; Erik S G Stroes; Rob F P van den Akker; Bert-Jan H van den Born; Dayanjan S Wijesinghe; Astrid E Alewijnse; Charles E Chalfant; Jo De Mey; Jacques J Debets; Gert B Eijkel; Ron M A Heeren; Ben J A Janssen; Luke MacAleese; Stephan L M Peters
Hypertension is associated with marked alterations in sphingolipid biology: a potential role for ceramide.
PloS one 2011;6(7):e21817.
2010: Frank J Raucci; Dayanjan S Wijesinghe; Charles E Chalfant; Clive M Baumgarten
Exogenous and endogenous ceramides elicit volume-sensitive chloride current in ventricular myocytes.
Cardiovascular research 2010;86(1):55-62.
2010: Dayanjan S Wijesinghe; Jeremy C Allegood; Luciana B Gentile; Todd E Fox; Mark Kester; Charles E Chalfant
Use of high performance liquid chromatography-electrospray ionization-tandem mass spectrometry for the analysis of ceramide-1-phosphate levels.
Journal of lipid research 2010;51(3):641-51.
2009: Dayanjan S Wijesinghe; Preeti Subramanian; Nadia F Lamour; Luciana B Gentile; Maria H Granado; Alicja Bielawska; Zdzislaw Szulc; Antonio Gomez-Munoz; Charles E Chalfant
Chain length specificity for activation of cPLA2alpha by C1P: use of the dodecane delivery system to determine lipid-specific effects.
Journal of lipid research 2009;50(10):1986-95.
2009: Nadia F Lamour; Preeti Subramanian; Dayanjan S Wijesinghe; Robert V Stahelin; Joseph V Bonventre; Charles E Chalfant
Ceramide 1-phosphate is required for the translocation of group IVA cytosolic phospholipase A2 and prostaglandin synthesis.
The Journal of biological chemistry 2009;284(39):26897-907.
2008: Nadia F Lamour; Charles E Chalfant
Ceramide kinase and the ceramide-1-phosphate/cPLA2alpha interaction as a therapeutic target.
Current drug targets 2008;9(8):674-82.
2007: Jacqueline C Shultz; Charles E Chalfant
Emetine and the alternative splicing of Bcl-X: where to next?
Chemistry & biology 2007;14(12):1313-4.
2007: Preeti Subramanian; Mohsin Vora; Luciana B Gentile; Robert V Stahelin; Charles E Chalfant
Anionic lipids activate group IVA cytosolic phospholipase A2 via distinct and separate mechanisms.
Journal of lipid research 2007;48(12):2701-8.
2007: Robert V Stahelin; Preeti Subramanian; Mohsin Vora; Wonhwa Cho; Charles E Chalfant
Ceramide-1-phosphate binds group IVA cytosolic phospholipase a2 via a novel site in the C2 domain.
The Journal of biological chemistry 2007;282(28):20467-74.
2007: Nadia F Lamour; Robert V Stahelin; Dayanjan S Wijesinghe; Michael Maceyka; Elaine Wang; Jeremy C Allegood; Alfred H Merrill; Wonhwa Cho; Charles E Chalfant
Ceramide kinase uses ceramide provided by ceramide transport protein: localization to organelles of eicosanoid synthesis.
Journal of lipid research 2007;48(6):1293-304.
2007: Maria Paola Paronetto; Tilman Achsel; Autumn Massiello; Charles E Chalfant; Claudio Sette
The RNA-binding protein Sam68 modulates the alternative splicing of Bcl-x.
The Journal of cell biology 2007;176(7):929-39.
2007: Nilanjan Ghosh; Niketa Patel; Kun Jiang; James E Watson; Jin Cheng; Charles E Chalfant; Denise R Cooper
Ceramide-activated protein phosphatase involvement in insulin resistance via Akt, serine/arginine-rich protein 40, and ribonucleic acid splicing in L6 skeletal muscle cells.
Endocrinology 2007;148(3):1359-66.
2007: Poulami Mitra; Michael Maceyka; Shawn G Payne; Nadia F Lamour; Sheldon Milstien; Charles E Chalfant; Sarah Spiegel
Ceramide kinase regulates growth and survival of A549 human lung adenocarcinoma cells.
FEBS letters 2007;581(4):735-40.
2007: Shawn G Payne; Carole A Oskeritzian; Rachael Griffiths; Preeti Subramanian; Suzanne E Barbour; Charles E Chalfant; Sheldon Milstien; Sarah Spiegel
The immunosuppressant drug FTY720 inhibits cytosolic phospholipase A2 independently of sphingosine-1-phosphate receptors.
Blood 2007;109(3):1077-85.
2007: Dayanjan S Wijesinghe; Nadia F Lamour; Antonio Gomez-Munoz; Charles E Chalfant
Ceramide kinase and ceramide-1-phosphate.
Methods in enzymology 2007;434():265-92.
2006: Brian O Barnstein; Geqiang Li; Zhengqi Wang; Sarah Kennedy; Charles E Chalfant; Hiroshi Nakajima; Kevin D Bunting; John J Ryan
Stat5 expression is required for IgE-mediated mast cell function.
Journal of immunology (Baltimore, Md. : 1950) 2006;177(5):3421-6.
2006: Autumn Massiello; James R Roesser; Charles E Chalfant
SAP155 Binds to ceramide-responsive RNA cis-element 1 and regulates the alternative 5' splice site selection of Bcl-x pre-mRNA.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2006;20(10):1680-2.
2006: Sucharita Bandyopadhyay; Rui Zhan; Ying Wang; Sudha K Pai; Shigeru Hirota; Sadahiro Hosobe; Yukio Takano; Ken Saito; Eiji Furuta; Megumi Iiizumi; Sonia Mohinta; Misako Watabe; Charles E Chalfant; Kounosuke Watabe
Mechanism of apoptosis induced by the inhibition of fatty acid synthase in breast cancer cells.
Cancer research 2006;66(11):5934-40.
2006: Autumn Massiello; Charles E Chalfant
SRp30a (ASF/SF2) regulates the alternative splicing of caspase-9 pre-mRNA and is required for ceramide-responsiveness.
Journal of lipid research 2006;47(5):892-7.
2006: W Scott Kim; Charles E Chalfant; Brett Garner
Fine tuning therapeutic targeting of the sphingolipid biosynthetic pathway to treat atherosclerosis.
Current vascular pharmacology 2006;4(2):151-4.
2006: Souha S Kanj; Nadine Dandashi; Aimee El-Hed; Hisham Harik; Maria Maalouf; Lina Kozhaya; Talal Mousallem; Ann E Tollefson; William S M Wold; Charles E Chalfant; Ghassan Dbaibo
Ceramide regulates SR protein phosphorylation during adenoviral infection.
Virology 2006;345(1):280-9.
2005: Nadia F Lamour; Charles E Chalfant
Ceramide-1-phosphate: the "missing" link in eicosanoid biosynthesis and inflammation.
Molecular interventions 2005;5(6):358-67.
2005: Dayanjan S Wijesinghe; Autumn Massiello; Preeti Subramanian; Zdzislaw Szulc; Alicja Bielawska; Charles E Chalfant
Substrate specificity of human ceramide kinase.
Journal of lipid research 2005;46(12):2706-16.
2005: Charles E Chalfant; Sarah Spiegel
Sphingosine 1-phosphate and ceramide 1-phosphate: expanding roles in cell signaling.
Journal of cell science 2005;118(Pt 20):4605-12.
2005: Benjamin J Pettus; Kazuyuki Kitatani; Charles E Chalfant; Tarek A Taha; Toshihiko Kawamori; Jacek Bielawski; Lina M Obeid; Yusuf A Hannun
The coordination of prostaglandin E2 production by sphingosine-1-phosphate and ceramide-1-phosphate.
Molecular pharmacology 2005;68(2):330-5.
2005: Preeti Subramanian; Robert V Stahelin; Zdzislaw Szulc; Alicja Bielawska; Wonhwa Cho; Charles E Chalfant
Ceramide 1-phosphate acts as a positive allosteric activator of group IVA cytosolic phospholipase A2 alpha and enhances the interaction of the enzyme with phosphatidylcholine.
The Journal of biological chemistry 2005;280(18):17601-7.
2004: Benjamin J Pettus; Charles E Chalfant; Yusuf A Hannun
Sphingolipids in inflammation: roles and implications.
Current molecular medicine 2004;4(4):405-18.
2004: Autumn Massiello; Arelis Salas; Ryan L Pinkerman; Patrick Roddy; James R Roesser; Charles E Chalfant
Identification of two RNA cis-elements that function to regulate the 5' splice site selection of Bcl-x pre-mRNA in response to ceramide.
The Journal of biological chemistry 2004;279(16):15799-804.
2004: Niketa A Patel; Hercules S Apostolatos; Konrad Mebert; Charles E Chalfant; James E Watson; T S Pillay; Janet Sparks; Denise R Cooper
Insulin regulates protein kinase CbetaII alternative splicing in multiple target tissues: development of a hormonally responsive heterologous minigene.
Molecular endocrinology (Baltimore, Md.) 2004;18(4):899-911.
2004: Benjamin J Pettus; Alicja Bielawska; Preeti Subramanian; Dayanjan S Wijesinghe; Michael Maceyka; Christina C Leslie; John H Evans; Jessica Freiberg; Patrick Roddy; Yusuf A Hannun; Charles E Chalfant
Ceramide 1-phosphate is a direct activator of cytosolic phospholipase A2.
The Journal of biological chemistry 2004;279(12):11320-6.
2004: Charles E Chalfant; Zdzislaw Szulc; Patrick Roddy; Alicja Bielawska; Yusuf A Hannun
The structural requirements for ceramide activation of serine-threonine protein phosphatases.
Journal of lipid research 2004;45(3):496-506.
2003: Benjamin J Pettus; Alicja Bielawska; Sarah Spiegel; Patrick Roddy; Yusuf A Hannun; Charles E Chalfant
Ceramide kinase mediates cytokine- and calcium ionophore-induced arachidonic acid release.
The Journal of biological chemistry 2003;278(40):38206-13.
2003: Benjamin J Pettus; Jacek Bielawski; Anna M Porcelli; Davis L Reames; Korey R Johnson; Jason Morrow; Charles E Chalfant; Lina M Obeid; Yusuf A Hannun
The sphingosine kinase 1/sphingosine-1-phosphate pathway mediates COX-2 induction and PGE2 production in response to TNF-alpha.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2003;17(11):1411-21.
2003: Niketa A Patel; Duane C Eichler; David S Chappell; Philip A Illingworth; Charles E Chalfant; Mayumi Yamamoto; Nicholas Dean; Jacqueline R Wyatt; Konrad Mebert; James E Watson; Denise R Cooper
The protein kinase C beta II exon confers mRNA instability in the presence of high glucose concentrations.
The Journal of biological chemistry 2003;278(2):1149-57.
2002: Benjamin J Pettus; Charles E Chalfant; Yusuf A Hannun
Ceramide in apoptosis: an overview and current perspectives.
Biochimica et biophysica acta 2002;1585(2-3):114-25.
2002: Gary M Jenkins; L Ashley Cowart; Paola Signorelli; Benjamin J Pettus; Charles E Chalfant; Yusuf A Hannun
Acute activation of de novo sphingolipid biosynthesis upon heat shock causes an accumulation of ceramide and subsequent dephosphorylation of SR proteins.
The Journal of biological chemistry 2002;277(45):42572-8.
2002: Charles E Chalfant; Kristin Rathman; Ryan L Pinkerman; Rachel E Wood; Lina M Obeid; Besim Ogretmen; Yusuf A Hannun
De novo ceramide regulates the alternative splicing of caspase 9 and Bcl-x in A549 lung adenocarcinoma cells. Dependence on protein phosphatase-1.
The Journal of biological chemistry 2002;277(15):12587-95.
2001: Charles E Chalfant; Besim Ogretmen; Sehamuddin Galadari; Bart-Jan Kroesen; Benjamin J Pettus; Yusuf A Hannun
FAS activation induces dephosphorylation of SR proteins; dependence on the de novo generation of ceramide and activation of protein phosphatase 1.
The Journal of biological chemistry 2001;276(48):44848-55.
2001: Niketa A Patel; Charles E Chalfant; James E Watson; Jacqueline R Wyatt; Nicholas Dean; Duane C Eichler; Denise R Cooper
Insulin regulates alternative splicing of protein kinase C beta II through a phosphatidylinositol 3-kinase-dependent pathway involving the nuclear serine/arginine-rich splicing factor, SRp40, in skeletal muscle cells.
The Journal of biological chemistry 2001;276(25):22648-54.
2000: Mayumi Yamamoto; Mildred Acevedo-Duncan; Charles E Chalfant; Niketa A Patel; James E Watson; Denise R Cooper
Acute glucose-induced downregulation of PKC-betaII accelerates cultured VSMC proliferation.
American journal of physiology. Cell physiology 2000;279(3):C587-95.
2000: Charles E Chalfant; Theodore P Ciaraldi; James E Watson; Svetlana E Nikoulina; Robert R Henry; Denise R Cooper
Protein kinase Ctheta expression is increased upon differentiation of human skeletal muscle cells: dysregulation in type 2 diabetic patients and a possible role for protein kinase Ctheta in insulin-stimulated glycogen synthase activity.
Endocrinology 2000;141(8):2773-8.
2000: Charles E Chalfant; K Kishikawa; Alicja Bielawska; Yusuf A Hannun
Analysis of ceramide-activated protein phosphatases.
Methods in enzymology 2000;312():420-8.
1999: Denise R Cooper; James E Watson; N Patel; P Illingworth; Mildred Acevedo-Duncan; JoAnne Goodnight; Charles E Chalfant; Mischak Harald
Ectopic expression of protein kinase CbetaII, -delta, and -epsilon, but not -betaI or -zeta, provide for insulin stimulation of glucose uptake in NIH-3T3 cells.
Archives of biochemistry and biophysics 1999;372(1):69-79.
1999: K Kishikawa; Charles E Chalfant; David K Perry; Alicja Bielawska; Yusuf A Hannun
Phosphatidic acid is a potent and selective inhibitor of protein phosphatase 1 and an inhibitor of ceramide-mediated responses.
The Journal of biological chemistry 1999;274(30):21335-41.
1999: Charles E Chalfant; K Kishikawa; Marc C Mumby; Craig Kamibayashi; Alicja Bielawska; Yusuf A Hannun
Long chain ceramides activate protein phosphatase-1 and protein phosphatase-2A. Activation is stereospecific and regulated by phosphatidic acid.
The Journal of biological chemistry 1999;274(29):20313-7.
1999: Niketa A Patel; Charles E Chalfant; M Yamamoto; James E Watson; Duane C Eichler; Denise R Cooper
Acute hyperglycemia regulates transcription and posttranscriptional stability of PKCbetaII mRNA in vascular smooth muscle cells.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1999;13(1):103-13.
1998: Mayumi Yamamoto; Mildred Acevedo-Duncan; Charles E Chalfant; Niketa A Patel; James E Watson; Denise R Cooper
The roles of protein kinase C beta I and beta II in vascular smooth muscle cell proliferation.
Experimental cell research 1998;240(2):349-58.
1998: Charles E Chalfant; James E Watson; L D Bisnauth; J B Kang; N Patel; Lina M Obeid; Duane C Eichler; Denise R Cooper
Insulin regulates protein kinase CbetaII expression through enhanced exon inclusion in L6 skeletal muscle cells. A novel mechanism of insulin- and insulin-like growth factor-i-induced 5' splice site selection.
The Journal of biological chemistry 1998;273(2):910-6.
1996: Charles E Chalfant; S Ohno; Y Konno; A A Fisher; L D Bisnauth; J E Watson; Denise R Cooper
A carboxy-terminal deletion mutant of protein kinase C beta II inhibits insulin-stimulated 2-deoxyglucose uptake in L6 rat skeletal muscle cells.
Molecular endocrinology (Baltimore, Md.) 1996;10(10):1273-81.
1996: R Coulson; P S Proch; R A Olsson; Charles E Chalfant; Denise R Cooper
Upregulated renal adenosine A1 receptors augment PKC and glucose transport but inhibit proliferation.
The American journal of physiology 1996;270(2 Pt 2):F263-74.
1995: Mildred Acevedo-Duncan; J Collins; R Zhang; Edward Haller; Charles E Chalfant; Denise R Cooper
In situ effects of interferon on human glioma protein kinase C-alpha and -beta ultrastructural localization.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 1995;6(11):1353-65.
1995: Charles E Chalfant; Mischak Harald; James E Watson; B C Winkler; J Goodnight; R V Farese; Denise R Cooper
Regulation of alternative splicing of protein kinase C beta by insulin.
The Journal of biological chemistry 1995;270(22):13326-32.
1994: William R Gower; John R Dietz; D L Vesely; C L Finley; K A Skolnick; P J Fabri; Denise R Cooper; Charles E Chalfant
Atrial natriuretic peptide gene expression in the rat gastrointestinal tract.
Biochemical and biophysical research communications 1994;202(1):562-70.