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Charles Chalfant
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Research Profile (preview)
Chemicals & Drugs
Anatomy
Living Beings
Physiology
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Network (preview)
15
Cooper, Denise
13
Hannun, Yusuf
11
Watson, James
8
Pettus, Benjamin
8
Bielawska, Alicja
7
Subramanian, Preeti
6
Patel, Niketa
6
Lamour, Nadia
5
Massiello, Autumn
5
Wijesinghe, Dayanjan
5
Stahelin, Robert
4
Spiegel, Sarah
4
Obeid, Lina
4
Roddy, Patrick
4
Acevedo-Duncan, Mildred
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Publications
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Geonetwork of Charles Chalfant (preview)
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All Publications
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2009: Lamour Nadia F; Subramanian Preeti; Wijesinghe Dayanjan S; Stahelin Robert V; Bonventre Joseph V; Chalfant Charles E
Ceramide 1-phosphate is required for the translocation of group IVA cytosolic phospholipase A2 and prostaglandin synthesis.
The Journal of biological chemistry 2009;284(39):26897-907.
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2008: Lamour Nadia F; Chalfant Charles E
Ceramide kinase and the ceramide-1-phosphate/cPLA2alpha interaction as a therapeutic target.
Current drug targets 2008;9(8):674-82.
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2007: Shultz Jacqueline C; Chalfant Charles E
Emetine and the alternative splicing of Bcl-X: where to next?
Chemistry & biology 2007;14(12):1313-4.
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2007: Subramanian Preeti; Vora Mohsin; Gentile Luciana B; Stahelin Robert V; Chalfant Charles E
Anionic lipids activate group IVA cytosolic phospholipase A2 via distinct and separate mechanisms.
Journal of lipid research 2007;48(12):2701-8.
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2007: Stahelin Robert V; Subramanian Preeti; Vora Mohsin; Cho Wonhwa; Chalfant Charles E
Ceramide-1-phosphate binds group IVA cytosolic phospholipase a2 via a novel site in the C2 domain.
The Journal of biological chemistry 2007;282(28):20467-74.
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2007: Lamour Nadia F; Stahelin Robert V; Wijesinghe Dayanjan S; Maceyka Michael; Wang Elaine; Allegood Jeremy C; Merrill Alfred H; Cho Wonhwa; Chalfant Charles E
Ceramide kinase uses ceramide provided by ceramide transport protein: localization to organelles of eicosanoid synthesis.
Journal of lipid research 2007;48(6):1293-304.
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2007: Paronetto Maria Paola; Achsel Tilman; Massiello Autumn; Chalfant Charles E; Sette Claudio
The RNA-binding protein Sam68 modulates the alternative splicing of Bcl-x.
The Journal of cell biology 2007;176(7):929-39.
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2007: Ghosh Nilanjan; Patel Niketa; Jiang Kun; Watson James E; Cheng Jin; Chalfant Charles E; Cooper Denise R
Ceramide-activated protein phosphatase involvement in insulin resistance via Akt, serine/arginine-rich protein 40, and ribonucleic acid splicing in L6 skeletal muscle cells.
Endocrinology 2007;148(3):1359-66.
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2007: Mitra Poulami; Maceyka Michael; Payne Shawn G; Lamour Nadia; Milstien Sheldon; Chalfant Charles E; Spiegel Sarah
Ceramide kinase regulates growth and survival of A549 human lung adenocarcinoma cells.
FEBS letters 2007;581(4):735-40.
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2007: Payne Shawn G; Oskeritzian Carole A; Griffiths Rachael; Subramanian Preeti; Barbour Suzanne E; Chalfant Charles E; Milstien Sheldon; Spiegel Sarah
The immunosuppressant drug FTY720 inhibits cytosolic phospholipase A2 independently of sphingosine-1-phosphate receptors.
Blood 2007;109(3):1077-85.
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2007: Wijesinghe Dayanjan S; Lamour Nadia F; Gomez-Munoz Antonio; Chalfant Charles E
Ceramide kinase and ceramide-1-phosphate.
Methods in enzymology 2007;434():265-92.
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2006: Barnstein Brian O; Li Geqiang; Wang Zhengqi; Kennedy Sarah; Chalfant Charles; Nakajima Hiroshi; Bunting Kevin D; Ryan John J
Stat5 expression is required for IgE-mediated mast cell function.
Journal of immunology (Baltimore, Md. : 1950) 2006;177(5):3421-6.
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2006: Massiello Autumn; Roesser James R; Chalfant Charles E
SAP155 Binds to ceramide-responsive RNA cis-element 1 and regulates the alternative 5' splice site selection of Bcl-x pre-mRNA.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2006;20(10):1680-2.
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2006: Bandyopadhyay Sucharita; Zhan Rui; Wang Ying; Pai Sudha K; Hirota Shigeru; Hosobe Sadahiro; Takano Yukio; Saito Ken; Furuta Eiji; Iiizumi Megumi; Mohinta Sonia; Watabe Misako; Chalfant Charles; Watabe Kounosuke
Mechanism of apoptosis induced by the inhibition of fatty acid synthase in breast cancer cells.
Cancer research 2006;66(11):5934-40.
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2006: Massiello Autumn; Chalfant Charles E
SRp30a (ASF/SF2) regulates the alternative splicing of caspase-9 pre-mRNA and is required for ceramide-responsiveness.
Journal of lipid research 2006;47(5):892-7.
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2006: Kim W Scott; Chalfant Charles E; Garner Brett
Fine tuning therapeutic targeting of the sphingolipid biosynthetic pathway to treat atherosclerosis.
Current vascular pharmacology 2006;4(2):151-4.
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2006: Kanj Souha S; Dandashi Nadine; El-Hed Aimee; Harik Hisham; Maalouf Maria; Kozhaya Lina; Mousallem Talal; Tollefson Ann E; Wold William S; Chalfant Charles E; Dbaibo Ghassan S
Ceramide regulates SR protein phosphorylation during adenoviral infection.
Virology 2006;345(1):280-9.
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2005: Lamour Nadia F; Chalfant Charles E
Ceramide-1-phosphate: the "missing" link in eicosanoid biosynthesis and inflammation.
Molecular interventions 2005;5(6):358-67.
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2005: Wijesinghe Dayanjan S; Massiello Autumn; Subramanian Preeti; Szulc Zdzislaw; Bielawska Alicja; Chalfant Charles E
Substrate specificity of human ceramide kinase.
Journal of lipid research 2005;46(12):2706-16.
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2005: Chalfant Charles E; Spiegel Sarah
Sphingosine 1-phosphate and ceramide 1-phosphate: expanding roles in cell signaling.
Journal of cell science 2005;118(Pt 20):4605-12.
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2005: Pettus Benjamin J; Kitatani Kazuyuki; Chalfant Charles E; Taha Tarek A; Kawamori Toshihiko; Bielawski Jacek; Obeid Lina M; Hannun Yusuf A
The coordination of prostaglandin E2 production by sphingosine-1-phosphate and ceramide-1-phosphate.
Molecular pharmacology 2005;68(2):330-5.
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2005: Subramanian Preeti; Stahelin Robert V; Szulc Zdzislaw; Bielawska Alicja; Cho Wonhwa; Chalfant Charles E
Ceramide 1-phosphate acts as a positive allosteric activator of group IVA cytosolic phospholipase A2 alpha and enhances the interaction of the enzyme with phosphatidylcholine.
The Journal of biological chemistry 2005;280(18):17601-7.
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2004: Pettus B J; Chalfant C E; Hannun Y A
Sphingolipids in inflammation: roles and implications.
Current molecular medicine 2004;4(4):405-18.
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2004: Patel Niketa A; Apostolatos Hercules S; Mebert Konrad; Chalfant Charles E; Watson James E; Pillay T S; Sparks Janet; Cooper Denise R
Insulin regulates protein kinase CbetaII alternative splicing in multiple target tissues: development of a hormonally responsive heterologous minigene.
Molecular endocrinology (Baltimore, Md.) 2004;18(4):899-911.
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2004: Massiello Autumn; Salas Arelis; Pinkerman Ryan L; Roddy Patrick; Roesser James R; Chalfant Charles E
Identification of two RNA cis-elements that function to regulate the 5' splice site selection of Bcl-x pre-mRNA in response to ceramide.
The Journal of biological chemistry 2004;279(16):15799-804.
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2004: Pettus Benjamin J; Bielawska Alicja; Subramanian Preeti; Wijesinghe Dayanjan S; Maceyka Michael; Leslie Christina C; Evans John H; Freiberg Jessica; Roddy Patrick; Hannun Yusuf A; Chalfant Charles E
Ceramide 1-phosphate is a direct activator of cytosolic phospholipase A2.
The Journal of biological chemistry 2004;279(12):11320-6.
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2004: Chalfant Charles E; Szulc Zdzislaw; Roddy Patrick; Bielawska Alicja; Hannun Yusuf A
The structural requirements for ceramide activation of serine-threonine protein phosphatases.
Journal of lipid research 2004;45(3):496-506.
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2003: Pettus Benjamin J; Bielawska Alicja; Spiegel Sarah; Roddy Patrick; Hannun Yusuf A; Chalfant Charles E
Ceramide kinase mediates cytokine- and calcium ionophore-induced arachidonic acid release.
The Journal of biological chemistry 2003;278(40):38206-13.
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2003: Pettus Benjamin J; Bielawski Jacek; Porcelli Anna M; Reames Davis L; Johnson Korey R; Morrow Jason; Chalfant Charles E; Obeid Lina M; Hannun Yusuf A
The sphingosine kinase 1/sphingosine-1-phosphate pathway mediates COX-2 induction and PGE2 production in response to TNF-alpha.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2003;17(11):1411-21.
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2003: Patel Niketa A; Eichler Duane C; Chappell David S; Illingworth Philip A; Chalfant Charles E; Yamamoto Mayumi; Dean Nicholas M; Wyatt Jacqueline R; Mebert Konrad; Watson James E; Cooper Denise R
The protein kinase C beta II exon confers mRNA instability in the presence of high glucose concentrations.
The Journal of biological chemistry 2003;278(2):1149-57.
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2002: Pettus Benjamin J; Chalfant Charles E; Hannun Yusuf A
Ceramide in apoptosis: an overview and current perspectives.
Biochimica et biophysica acta 2002;1585(2-3):114-25.
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2002: Jenkins Gary M; Cowart L Ashley; Signorelli Paola; Pettus Benjamin J; Chalfant Charles E; Hannun Yusuf A
Acute activation of de novo sphingolipid biosynthesis upon heat shock causes an accumulation of ceramide and subsequent dephosphorylation of SR proteins.
The Journal of biological chemistry 2002;277(45):42572-8.
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2002: Chalfant Charles E; Rathman Kristin; Pinkerman Ryan L; Wood Rachel E; Obeid Lina M; Ogretmen Besim; Hannun Yusuf A
De novo ceramide regulates the alternative splicing of caspase 9 and Bcl-x in A549 lung adenocarcinoma cells. Dependence on protein phosphatase-1.
The Journal of biological chemistry 2002;277(15):12587-95.
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2001: Chalfant C E; Ogretmen B; Galadari S; Kroesen B J; Pettus B J; Hannun Y A
FAS activation induces dephosphorylation of SR proteins; dependence on the de novo generation of ceramide and activation of protein phosphatase 1.
The Journal of biological chemistry 2001;276(48):44848-55.
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2001: Patel N A; Chalfant C E; Watson J E; Wyatt J R; Dean N M; Eichler D C; Cooper D R
Insulin regulates alternative splicing of protein kinase C beta II through a phosphatidylinositol 3-kinase-dependent pathway involving the nuclear serine/arginine-rich splicing factor, SRp40, in skeletal muscle cells.
The Journal of biological chemistry 2001;276(25):22648-54.
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2000: Yamamoto M; Acevedo-Duncan M; Chalfant C E; Patel N A; Watson J E; Cooper D R
Acute glucose-induced downregulation of PKC-betaII accelerates cultured VSMC proliferation.
American journal of physiology. Cell physiology 2000;279(3):C587-95.
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2000: Chalfant C E; Ciaraldi T P; Watson J E; Nikoulina S; Henry R R; Cooper D R
Protein kinase Ctheta expression is increased upon differentiation of human skeletal muscle cells: dysregulation in type 2 diabetic patients and a possible role for protein kinase Ctheta in insulin-stimulated glycogen synthase activity.
Endocrinology 2000;141(8):2773-8.
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2000: Chalfant C E; Kishikawa K; Bielawska A; Hannun Y A
Analysis of ceramide-activated protein phosphatases.
Methods in enzymology 2000;312():420-8.
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1999: Cooper D R; Watson J E; Patel N; Illingworth P; Acevedo-Duncan M; Goodnight J; Chalfant C E; Mischak H
Ectopic expression of protein kinase CbetaII, -delta, and -epsilon, but not -betaI or -zeta, provide for insulin stimulation of glucose uptake in NIH-3T3 cells.
Archives of biochemistry and biophysics 1999;372(1):69-79.
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1999: Kishikawa K; Chalfant C E; Perry D K; Bielawska A; Hannun Y A
Phosphatidic acid is a potent and selective inhibitor of protein phosphatase 1 and an inhibitor of ceramide-mediated responses.
The Journal of biological chemistry 1999;274(30):21335-41.
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1999: Chalfant C E; Kishikawa K; Mumby M C; Kamibayashi C; Bielawska A; Hannun Y A
Long chain ceramides activate protein phosphatase-1 and protein phosphatase-2A. Activation is stereospecific and regulated by phosphatidic acid.
The Journal of biological chemistry 1999;274(29):20313-7.
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1999: Patel N A; Chalfant C E; Yamamoto M; Watson J E; Eichler D C; Cooper D R
Acute hyperglycemia regulates transcription and posttranscriptional stability of PKCbetaII mRNA in vascular smooth muscle cells.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1999;13(1):103-13.
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1998: Yamamoto M; Acevedo-Duncan M; Chalfant C E; Patel N A; Watson J E; Cooper D R
The roles of protein kinase C beta I and beta II in vascular smooth muscle cell proliferation.
Experimental cell research 1998;240(2):349-58.
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1998: Chalfant C E; Watson J E; Bisnauth L D; Kang J B; Patel N; Obeid L M; Eichler D C; Cooper D R
Insulin regulates protein kinase CbetaII expression through enhanced exon inclusion in L6 skeletal muscle cells. A novel mechanism of insulin- and insulin-like growth factor-i-induced 5' splice site selection.
The Journal of biological chemistry 1998;273(2):910-6.
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1996: Chalfant C E; Ohno S; Konno Y; Fisher A A; Bisnauth L D; Watson J E; Cooper D R
A carboxy-terminal deletion mutant of protein kinase C beta II inhibits insulin-stimulated 2-deoxyglucose uptake in L6 rat skeletal muscle cells.
Molecular endocrinology (Baltimore, Md.) 1996;10(10):1273-81.
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1996: Coulson R; Proch P S; Olsson R A; Chalfant C E; Cooper D R
Upregulated renal adenosine A1 receptors augment PKC and glucose transport but inhibit proliferation.
The American journal of physiology 1996;270(2 Pt 2):F263-74.
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1995: Acevedo-Duncan M; Collins J; Zhang R; Haller E; Chalfant C E; Cooper D R
In situ effects of interferon on human glioma protein kinase C-alpha and -beta ultrastructural localization.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 1995;6(11):1353-65.
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1995: Chalfant C E; Mischak H; Watson J E; Winkler B C; Goodnight J; Farese R V; Cooper D R
Regulation of alternative splicing of protein kinase C beta by insulin.
The Journal of biological chemistry 1995;270(22):13326-32.
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1994: Gower W R; Dietz J R; Vesely D L; Finley C L; Skolnick K A; Fabri P J; Cooper D R; Chalfant C E
Atrial natriuretic peptide gene expression in the rat gastrointestinal tract.
Biochemical and biophysical research communications 1994;202(1):562-70.
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