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Victor Darley-Usmar

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Timothy D Cummins; Victor Darley-Usmar; Louis J Dell'Italia; Ashlee N Higdon; Philip A Kramer; Daniel W Riggs; Joshua K Salabei; Jianhua Zhang; Balu K Chacko; Bradford G Hill
Utilization of fluorescent probes for the quantification and identification of subcellular proteomes and biological processes regulated by lipid peroxidation products.
Tanecia Mitchell; Jianhua Zhang; Shannon M Bailey; Scott W Ballinger; Balu Chacko; Victor Darley-Usmar
Convergent mechanisms for dysregulation of mitochondrial quality control in metabolic disease: implications for mitochondrial therapeutics.
Ashlee N Higdon; Aimee Landar; Stephen Barnes; Victor Darley-Usmar
The electrophile responsive proteome: integrating proteomics and lipidomics with cellular function.

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2013: Timothy D Cummins; Victor Darley-Usmar; Louis J Dell'Italia; Ashlee N Higdon; Philip A Kramer; Daniel W Riggs; Joshua K Salabei; Jianhua Zhang; Balu K Chacko; Bradford G Hill
Utilization of fluorescent probes for the quantification and identification of subcellular proteomes and biological processes regulated by lipid peroxidation products.
Free radical biology & medicine 2013;59():56-68.
2013: Tanecia Mitchell; Jianhua Zhang; Shannon M Bailey; Scott W Ballinger; Balu Chacko; Victor Darley-Usmar
Convergent mechanisms for dysregulation of mitochondrial quality control in metabolic disease: implications for mitochondrial therapeutics.
Biochemical Society transactions 2013;41(1):127-33.
2012: Ashlee N Higdon; Aimee Landar; Stephen Barnes; Victor Darley-Usmar
The electrophile responsive proteome: integrating proteomics and lipidomics with cellular function.
Antioxidants & redox signaling 2012;17(11):1580-9.
2012: Tanecia Mitchell; Balu K Chacko; Victor Darley-Usmar
Controlling radicals in the powerhouse: development of MitoSOD.
Chemistry & biology 2012;19(10):1217-8.
2012: Ashlee N Higdon; Michelle S Johnson; Aimee Landar; Xiaosen Ouyang; Jianhua Zhang; Gloria A Benavides; Balu K Chacko; Victor Darley-Usmar
Hemin causes mitochondrial dysfunction in endothelial cells through promoting lipid peroxidation: the protective role of autophagy.
American journal of physiology. Heart and circulatory physiology 2012;302(7):H1394-409.
2012: Ashlee Higdon; Aimee Landar; Joo-Yeun Oh; Anne R Diers; Victor Darley-Usmar
Cell signalling by reactive lipid species: new concepts and molecular mechanisms.
The Biochemical journal 2012;442(3):453-64.
2012: Tanecia Mitchell; Victor Darley-Usmar
Metabolic syndrome and mitochondrial dysfunction: insights from preclinical studies with a mitochondrially targeted antioxidant.
Free radical biology & medicine 2012;52(5):838-40.
2012: Victor Darley-Usmar; Lauren E Ball; John C Chatham
Protein O-linked β-N-acetylglucosamine: a novel effector of cardiomyocyte metabolism and function.
Journal of molecular and cellular cardiology 2012;52(3):538-49.
2012: Samantha Giordano; Jisun Lee; Victor Darley-Usmar; Jianhua Zhang
Distinct effects of rotenone, 1-methyl-4-phenylpyridinium and 6-hydroxydopamine on cellular bioenergetics and cell death.
PloS one 2012;7(9):e44610.
2012: Balaraman Kalyanaraman; Giovanni E Mann; Phyllis A Dennery; L Jackson Roberts; Matthew B Grisham; Kelvin J A Davies; Kevin Moore; Victor Darley-Usmar; Henry Jay Forman; Harry Ischiropoulos
Measuring reactive oxygen and nitrogen species with fluorescent probes: challenges and limitations.
Free radical biology & medicine 2012;52(1):1-6.
2011: Blake R Zelickson; Michelle S Johnson; Aimee Landar; Aparna Venkatraman; Shannon M Bailey; Gloria A Benavides; Angela M Betancourt; Balu K Chacko; Victor Darley-Usmar
Nitric oxide and hypoxia exacerbate alcohol-induced mitochondrial dysfunction in hepatocytes.
Biochimica et biophysica acta 2011;1807(12):1573-82.
2011: Lonnie Schneider; Blake R Zelickson; Gloria A Benavides; Victor Darley-Usmar; Naomi S Fineberg; Samantha Giordano; Xiaosen Ouyang; Michelle S Johnson; Jianhua Zhang
Differentiation of SH-SY5Y cells to a neuronal phenotype changes cellular bioenergetics and the response to oxidative stress.
Free radical biology & medicine 2011;51(11):2007-17.
2011: James D Gladden; Elena Ulasova; Chih-Chang Wei; Blake R Zelickson; Junying Zheng; Mustafa I Ahmed; Scott W Ballinger; Marcas Bamman; Yuanwen Chen; Victor Darley-Usmar; Louis J Dell'Italia
Novel insights into interactions between mitochondria and xanthine oxidase in acute cardiac volume overload.
Free radical biology & medicine 2011;51(11):1975-84.
2011: Brian P Dranka; Samantha Giordano; Bradford G Hill; Aimee Landar; Colin Reily; Blake R Zelickson; Jianhua Zhang; Luyun Zou; Gloria A Benavides; John C Chatham; Anne R Diers; Victor Darley-Usmar
Assessing bioenergetic function in response to oxidative stress by metabolic profiling.
Free radical biology & medicine 2011;51(9):1621-35.
2011: Imad Al Ghouleh; Aaron Barchowsky; Phillip M Bauer; Eugenia Cifuentes-Pagano; Victor Darley-Usmar; Bruce A Freeman; Mark T Gladwin; Kathy K Griendling; Eric E Kelley; Nicholas K H Khoo; Ulla G Knaus; William M Nauseef; Sruti Shiva; Victor J Thannickal; Rhian M Touyz; Patrick J Pagano
Oxidases and peroxidases in cardiovascular and lung disease: new concepts in reactive oxygen species signaling.
Free radical biology & medicine 2011;51(7):1271-88.
2011: Anne R Diers; Katarzyna A Broniowska; Victor Darley-Usmar; Neil Hogg
Differential regulation of metabolism by nitric oxide and S-nitrosothiols in endothelial cells.
American journal of physiology. Heart and circulatory physiology 2011;301(3):H803-12.
2011: James D Gladden; Himanshu Gupta; Silvio Litovsky; Steven G Lloyd; David C McGiffin; Chun G Schiros; Mustafa I Ahmed; Victor Darley-Usmar; Thomas S Denney; Louis J Dell'Italia
Oxidative stress and myocardial remodeling in chronic mitral regurgitation.
The American journal of the medical sciences 2011;342(2):114-9.
2011: Balu K Chacko; Mi Jung Chang; Gloria A Benavides; Nirag Jhala; Michelle S Johnson; Balaraman Kalyanaraman; Michael P Murphy; Anup Srivastava; Yaozu Ye; Victor Darley-Usmar
Mitochondria-targeted ubiquinone (MitoQ) decreases ethanol-dependent micro and macro hepatosteatosis.
Hepatology (Baltimore, Md.) 2011;54(1):153-63.
2011: Jessica Perez; Petra Rocic; Rebecca A Torres; David S Weber; Mary J Cismowski; Victor Darley-Usmar; Pamela A Lucchesi
PYK2 signaling is required for PDGF-dependent vascular smooth muscle cell proliferation.
American journal of physiology. Cell physiology 2011;301(1):C242-51.
2011: Sang-Hyun Lee; Claus Schneider; Victor Darley-Usmar; Ashlee N Higdon; Chang Y Chung
Role of iPLA(2) in the regulation of Src trafficking and microglia chemotaxis.
Traffic (Copenhagen, Denmark) 2011;12(7):878-89.
2011: Brian E Sansbury; Steven P Jones; Daniel W Riggs; Victor Darley-Usmar; Bradford G Hill
Bioenergetic function in cardiovascular cells: the importance of the reserve capacity and its biological regulation.
Chemico-biological interactions 2011;191(1-3):288-95.
2011: Elena Ulasova; James D Gladden; Yuanwen Chen; Junying Zheng; Betty Pat; Wayne Bradley; Pamela Powell; Jaroslaw W Zmijewski; Blake R Zelickson; Scott W Ballinger; Victor Darley-Usmar; Louis J Dell'Italia
Loss of interstitial collagen causes structural and functional alterations of cardiomyocyte subsarcolemmal mitochondria in acute volume overload.
Journal of molecular and cellular cardiology 2011;50(1):147-56.
2010: Claudia R Oliva; Susan E Nozell; Anne Diers; Samuel G McClugage; Jann N Sarkaria; James M Markert; Victor Darley-Usmar; Shannon M Bailey; G Yancey Gillespie; Aimee Landar; Corinne E Griguer
Acquisition of temozolomide chemoresistance in gliomas leads to remodeling of mitochondrial electron transport chain.
The Journal of biological chemistry 2010;285(51):39759-67.
2010: Balu K Chacko; Colin Reily; Anup Srivastava; Michelle S Johnson; Yaozu Ye; Elena Ulasova; Anupam Agarwal; Kurt R Zinn; Michael P Murphy; Balaraman Kalyanaraman; Victor Darley-Usmar
Prevention of diabetic nephropathy in Ins2(+/)⁻(AkitaJ) mice by the mitochondria-targeted therapy MitoQ.
The Biochemical journal 2010;432(1):9-19.
2010: Bradford G Hill; Brian P Dranka; Shannon M Bailey; Jack R Lancaster; Victor Darley-Usmar
What part of NO don't you understand? Some answers to the cardinal questions in nitric oxide biology.
The Journal of biological chemistry 2010;285(26):19699-704.
2010: Jessica Perez; Bradford G Hill; Gloria A Benavides; Brian P Dranka; Victor Darley-Usmar
Role of cellular bioenergetics in smooth muscle cell proliferation induced by platelet-derived growth factor.
The Biochemical journal 2010;428(2):255-67.
2010: Brian P Dranka; Bradford G Hill; Victor Darley-Usmar
Mitochondrial reserve capacity in endothelial cells: The impact of nitric oxide and reactive oxygen species.
Free radical biology & medicine 2010;48(7):905-14.
2010: Anne R Diers; Ashlee N Higdon; Karina C Ricart; Michelle S Johnson; Anupam Agarwal; Balaraman Kalyanaraman; Aimee Landar; Victor Darley-Usmar
Mitochondrial targeting of the electrophilic lipid 15-deoxy-Delta12,14-prostaglandin J2 increases apoptotic efficacy via redox cell signalling mechanisms.
The Biochemical journal 2010;426(1):31-41.
2010: Bradford G Hill; Ashlee N Higdon; Brian P Dranka; Victor Darley-Usmar
Regulation of vascular smooth muscle cell bioenergetic function by protein glutathiolation.
Biochimica et biophysica acta 2010;1797(2):285-95.
2010: David G Nicholls; Victor Darley-Usmar; Min Wu; Per Bo Jensen; George W Rogers; David A Ferrick
Bioenergetic profile experiment using C2C12 myoblast cells.
Journal of visualized experiments : JoVE 2010;(46):.
2009: Bradford G Hill; Brian P Dranka; Luyun Zou; John C Chatham; Victor Darley-Usmar
Importance of the bioenergetic reserve capacity in response to cardiomyocyte stress induced by 4-hydroxynonenal.
The Biochemical journal 2009;424(1):99-107.
2009: Ashlee N Higdon; Brian P Dranka; Bradford G Hill; Joo-Yeun Oh; Michelle S Johnson; Aimee Landar; Victor Darley-Usmar
Methods for imaging and detecting modification of proteins by reactive lipid species.
Free radical biology & medicine 2009;47(3):201-12.
2009: Boglarka Laczy; Bradford G Hill; Kai Wang; Andrew J Paterson; C Roger White; Dongqi Xing; Yiu-Fai Chen; Victor Darley-Usmar; Suzanne Oparil; John C Chatham
Protein O-GlcNAcylation: a new signaling paradigm for the cardiovascular system.
American journal of physiology. Heart and circulatory physiology 2009;296(1):H13-28.
2009: Sudheer K Mantena; Denty Paul Vaughn; Kelly K Andringa; Heather B Eccleston; Adrienne L King; Gary A Abrams; Jeannette E Doeller; David Kraus; Victor Darley-Usmar; Shannon M Bailey
High fat diet induces dysregulation of hepatic oxygen gradients and mitochondrial function in vivo.
The Biochemical journal 2009;417(1):183-93.
2008: Bradford G Hill; Victor Darley-Usmar
S-nitrosation and thiol switching in the mitochondrion: a new paradigm for cardioprotection in ischaemic preconditioning.
The Biochemical journal 2008;412(2):e11-3.
2008: Chang Hyun Byon; Amjad Javed; Qun Dai; John C Kappes; Thomas Landes Clemens; Victor Darley-Usmar; Jay M McDonald; Yabing Chen
Oxidative stress induces vascular calcification through modulation of the osteogenic transcription factor Runx2 by AKT signaling.
The Journal of biological chemistry 2008;283(22):15319-27.
2008: Joo-Yeun Oh; Niroshini M Giles; Aimee Landar; Victor Darley-Usmar
Accumulation of 15-deoxy-delta(12,14)-prostaglandin J2 adduct formation with Keap1 over time: effects on potency for intracellular antioxidant defence induction.
The Biochemical journal 2008;411(2):297-306.
2008: Erin M Shonsey; S M Eliuk; M S Johnson; Stephen Barnes; Charles N Falany; Victor Darley-Usmar; Matthew B Renfrow
Inactivation of human liver bile acid CoA:amino acid N-acyltransferase by the electrophilic lipid, 4-hydroxynonenal.
Journal of lipid research 2008;49(2):282-94.
2008: Shannon M Bailey; Kelly K Andringa; Aimee Landar; Victor Darley-Usmar
Proteomic approaches to identify and characterize alterations to the mitochondrial proteome in alcoholic liver disease.
Methods in molecular biology (Clifton, N.J.) 2008;447():369-80.
2007: Gloria A Benavides; Giuseppe Squadrito; Robert W Mills; Hetal D Patel; T Scott Isbell; Rakesh P Patel; Victor Darley-Usmar; Jeannette E Doeller; David Kraus
Hydrogen sulfide mediates the vasoactivity of garlic.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(46):17977-82.
2007: Sudheer K Mantena; Adrienne L King; Kelly K Andringa; Aimee Landar; Victor Darley-Usmar; Shannon M Bailey
Novel interactions of mitochondria and reactive oxygen/nitrogen species in alcohol mediated liver disease.
World journal of gastroenterology : WJG 2007;13(37):4967-73.
2007: Aimee Landar; Victor Darley-Usmar
Evidence for oxygen as the master regulator of the responsiveness of soluble guanylate cyclase and cytochrome c oxidase to nitric oxide.
The Biochemical journal 2007;405(2):e3-4.
2007: Francois M Booyse; Wensheng Pan; Hernan E Grenett; Dale A Parks; Victor Darley-Usmar; Kelley M Bradley; Edlue M Tabengwa
Mechanism by which alcohol and wine polyphenols affect coronary heart disease risk.
Annals of epidemiology 2007;17(5 Suppl):S24-31.
2007: Jeffrey R Koenitzer; T Scott Isbell; Hetal D Patel; Gloria A Benavides; Dale A Dickinson; Rakesh P Patel; Victor Darley-Usmar; Jack R Lancaster; Jeannette E Doeller; David Kraus
Hydrogen sulfide mediates vasoactivity in an O2-dependent manner.
American journal of physiology. Heart and circulatory physiology 2007;292(4):H1953-60.
2007: Sruti Shiva; Zhi Huang; Rozalina Grubina; Junhui Sun; Lorna A Ringwood; Peter H MacArthur; Xiuli Xu; Elizabeth Murphy; Victor Darley-Usmar; Mark T Gladwin
Deoxymyoglobin is a nitrite reductase that generates nitric oxide and regulates mitochondrial respiration.
Circulation research 2007;100(5):654-61.
2007: Aimee Landar; Victor Darley-Usmar
Is the soluble guanylate cyclase pathway the only one available for nitric oxide (NO) signaling?
IUBMB life 2007;59(2):110-2.
2007: Sruti Shiva; Paul S Brookes; Victor Darley-Usmar
Methods for measuring the regulation of respiration by nitric oxide.
Methods in cell biology 2007;80():395-416.
2006: Shannon M Bailey; Gloria Robinson; Anita Pinner; Laura Chamlee; Elena Ulasova; MELISSA POMPILIUS; Grier P Page; David C Chhieng; Nirag C Jhala; Aimee Landar; Kusum K Kharbanda; Scott W Ballinger; Victor Darley-Usmar
S-adenosylmethionine prevents chronic alcohol-induced mitochondrial dysfunction in the rat liver.
American journal of physiology. Gastrointestinal and liver physiology 2006;291(5):G857-67.
2006: Jessica Gutierrez; Scott W Ballinger; Victor Darley-Usmar; Aimee Landar
Free radicals, mitochondria, and oxidized lipids: the emerging role in signal transduction in vascular cells.
Circulation research 2006;99(9):924-32.
2006: Nobuo Watanabe; Jaroslaw W Zmijewski; Wakako Takabe; Makiko Umezu-Goto; Claire Le Goffe; Azusa Sekine; Aimee Landar; Akira Watanabe; Junken Aoki; Hiroyuki Arai; Tatsuhiko Kodama; Michael P Murphy; Raman Kalyanaraman; Victor Darley-Usmar; Noriko Noguchi
Activation of mitogen-activated protein kinases by lysophosphatidylcholine-induced mitochondrial reactive oxygen species generation in endothelial cells.
The American journal of pathology 2006;168(5):1737-48.
2006: Aimee Landar; Jaroslaw W Zmijewski; Dale A Dickinson; Claire Le Goffe; Michelle S Johnson; Ginger L Milne; Giuseppe Zanoni; Giovanni Vidari; Jason D Morrow; Victor Darley-Usmar
Interaction of electrophilic lipid oxidation products with mitochondria in endothelial cells and formation of reactive oxygen species.
American journal of physiology. Heart and circulatory physiology 2006;290(5):H1777-87.
2006: Aimee Landar; Sruti Shiva; Anna-Liisa Levonen; Joo-Yeun Oh; Corinne Zaragoza; Michelle S Johnson; Victor Darley-Usmar
Induction of the permeability transition and cytochrome c release by 15-deoxy-Delta12,14-prostaglandin J2 in mitochondria.
The Biochemical journal 2006;394(Pt 1):185-95.
2006: Aimee Landar; Joo-Yeun Oh; Niroshini M Giles; Amanda Isom; Marion Kirk; Stephen Barnes; Victor Darley-Usmar
A sensitive method for the quantitative measurement of protein thiol modification in response to oxidative stress.
Free radical biology & medicine 2006;40(3):459-68.
2006: Jack H Crawford; T Scott Isbell; Zhi Huang; Sruti Shiva; Balu K Chacko; Alan N Schechter; Victor Darley-Usmar; Jeffrey D Kerby; John D Lang; David Kraus; Chien Ho; Mark T Gladwin; Rakesh P Patel
Hypoxia, red blood cells, and nitrite regulate NO-dependent hypoxic vasodilation.
Blood 2006;107(2):566-74.
2005: Jaroslaw W Zmijewski; Aimee Landar; N Watanabe; Dale A Dickinson; Noriko Noguchi; Victor Darley-Usmar
Cell signalling by oxidized lipids and the role of reactive oxygen species in the endothelium.
Biochemical Society transactions 2005;33(Pt 6):1385-9.
2005: Gyongyi Szabo; Jan B Hoek; Victor Darley-Usmar; Gyorgy Hajn\u2264czky; Amar Singh; Daria Mochly-Rosen; Samir Zakhari
RSA 2004: combined basic research satellite symposium - session three: alcohol and mitochondrial metabolism: at the crossroads of life and death.
Alcoholism, clinical and experimental research 2005;29(9):1749-52.
2005: Laila H Abou-Agag; Nicholas K H Khoo; Ralf Binsack; C Roger White; Victor Darley-Usmar; Hernan E Grenett; Francois M Booyse; Stanley B Digerness; Fen Zhou; Dale A Parks
Evidence of cardiovascular protection by moderate alcohol: role of nitric oxide.
Free radical biology & medicine 2005;39(4):540-8.
2005: Jaroslaw W Zmijewski; Douglas R Moellering; Claire Le Goffe; Aimee Landar; Anup Ramachandran; Victor Darley-Usmar
Oxidized LDL induces mitochondrially associated reactive oxygen/nitrogen species formation in endothelial cells.
American journal of physiology. Heart and circulatory physiology 2005;289(2):H852-61.
2005: Jeannette E Doeller; T Scott Isbell; Gloria A Benavides; Jeffrey R Koenitzer; Hetal Patel; Rakesh P Patel; Jack R Lancaster; Victor Darley-Usmar; David Kraus
Polarographic measurement of hydrogen sulfide production and consumption by mammalian tissues.
Analytical biochemistry 2005;341(1):40-51.
2005: Aimee Landar; Victor Darley-Usmar
Nitric oxide signaling gone awry: nitration of glutamine synthetase and hyperammonemia in sepsis.
Hepatology (Baltimore, Md.) 2005;41(5):980-2.
2005: Sruti Shiva; Joo-Yeun Oh; Aimee Landar; Elena Ulasova; Aparna Venkatraman; Shannon M Bailey; Victor Darley-Usmar
Nitroxia: the pathological consequence of dysfunction in the nitric oxide-cytochrome c oxidase signaling pathway.
Free radical biology & medicine 2005;38(3):297-306.
2005: Shannon M Bailey; Aimee Landar; Victor Darley-Usmar
Mitochondrial proteomics in free radical research.
Free radical biology & medicine 2005;38(2):175-88.
2005: Tracy L D'Alessandro; Brenda J Boersma-Maland; T Greg Peterson; Jeffrey N Sfakianos; Jeevan K Prasain; Rakesh P Patel; Victor Darley-Usmar; Nigel Botting; Stephen Barnes
Metabolism of phytoestrogen conjugates.
Methods in enzymology 2005;400():316-42.
2004: Dale A Dickinson; Anna-Liisa Levonen; Douglas R Moellering; Erin K Arnold; Hongqiao Zhang; Victor Darley-Usmar; Henry Jay Forman
Human glutamate cysteine ligase gene regulation through the electrophile response element.
Free radical biology & medicine 2004;37(8):1152-9.
2004: Victor Darley-Usmar
The powerhouse takes control of the cell; the role of mitochondria in signal transduction.
Free radical biology & medicine 2004;37(6):753-4.
2004: Aparna Venkatraman; Sruti Shiva; Amanda F Wigley; Elena Ulasova; David C Chhieng; Shannon M Bailey; Victor Darley-Usmar
The role of iNOS in alcohol-dependent hepatotoxicity and mitochondrial dysfunction in mice.
Hepatology (Baltimore, Md.) 2004;40(3):565-73.
2004: Catherine Fenster; Victor Darley-Usmar; Aimee Landar; Barbara A Gower; Roland L Weinsier; Gary R Hunter; Rakesh P Patel
Weight loss and race modulate nitric oxide metabolism in overweight women.
Free radical biology & medicine 2004;37(5):695-702.
2004: Amanda L Isom; Stephen Barnes; Landon Wilson; Marion Kirk; Lori Coward; Victor Darley-Usmar
Modification of Cytochrome c by 4-hydroxy- 2-nonenal: evidence for histidine, lysine, and arginine-aldehyde adducts.
Journal of the American Society for Mass Spectrometry 2004;15(8):1136-47.
2004: Christopher Kevil; Heather M Pruitt; T J Kavanagh; Jasmine Wilkerson; Federico M Farin; Douglas R Moellering; Victor Darley-Usmar; Daniel C Bullard; Rakesh P Patel
Regulation of endothelial glutathione by ICAM-1: implications for inflammation.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2004;18(11):1321-3.
2004: Aparna Venkatraman; Aimee Landar; Ashley J Davis; Laura Chamlee; Todd Sanderson; Helen Kim; Grier Page; MELISSA POMPILIUS; Scott W Ballinger; Victor Darley-Usmar; Shannon M Bailey
Modification of the mitochondrial proteome in response to the stress of ethanol-dependent hepatotoxicity.
The Journal of biological chemistry 2004;279(21):22092-101.
2004: Sruti Shiva; Jack H Crawford; Anup Ramachandran; Erin K Ceaser; Tess Hillson; Paul S Brookes; Rakesh P Patel; Victor Darley-Usmar
Mechanisms of the interaction of nitroxyl with mitochondria.
The Biochemical journal 2004;379(Pt 2):359-66.
2004: Aparna Venkatraman; Aimee Landar; Ashley J Davis; Elena Ulasova; Grier Page; Michael P Murphy; Victor Darley-Usmar; Shannon M Bailey
Oxidative modification of hepatic mitochondria protein thiols: effect of chronic alcohol consumption.
American journal of physiology. Gastrointestinal and liver physiology 2004;286(4):G521-7.
2004: C Roger White; Dale A Parks; Rakesh P Patel; Jonathan Shelton; Margaret M Tarpey; Bruce Freeman; Victor Darley-Usmar
L-Arginine inhibits xanthine oxidase-dependent endothelial dysfunction in hypercholesterolemia.
FEBS letters 2004;561(1-3):94-8.
2004: Anna-Liisa Levonen; Aimee Landar; Anup Ramachandran; Erin K Ceaser; Dale A Dickinson; Giuseppe Zanoni; Jason D Morrow; Victor Darley-Usmar
Cellular mechanisms of redox cell signalling: role of cysteine modification in controlling antioxidant defences in response to electrophilic lipid oxidation products.
The Biochemical journal 2004;378(Pt 2):373-82.
2004: Erin K Ceaser; Douglas R Moellering; Sruti Shiva; Anup Ramachandran; Aimee Landar; A Venkartraman; J Crawford; R Patel; Dale A Dickinson; Elena Ulasova; S Ji; Victor Darley-Usmar
Mechanisms of signal transduction mediated by oxidized lipids: the role of the electrophile-responsive proteome.
Biochemical Society transactions 2004;32(Pt 1):151-5.
2004: Anup Ramachandran; Erin K Ceaser; Victor Darley-Usmar
Chronic exposure to nitric oxide alters the free iron pool in endothelial cells: role of mitochondrial respiratory complexes and heat shock proteins.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(1):384-9.
2004: Sruti Shiva; Douglas R Moellering; Anup Ramachandran; Anna-Liisa Levonen; Aimee Landar; Aparna Venkatraman; Erin K Ceaser; Elena Ulasova; Jack H Crawford; Paul S Brookes; Rakesh P Patel; Victor Darley-Usmar
Redox signalling: from nitric oxide to oxidized lipids.
Biochemical Society symposium 2004;(71):107-20.
2004: Paul S Brookes; Victor Darley-Usmar
Role of calcium and superoxide dismutase in sensitizing mitochondria to peroxynitrite-induced permeability transition.
American journal of physiology. Heart and circulatory physiology 2004;286(1):H39-46.
2003: Aimee Landar; Victor Darley-Usmar
Nitric oxide and cell signaling: modulation of redox tone and protein modification.
Amino acids 2003;25(3-4):313-21.
2003: Brenda J Boersma; Tracy L D'Alessandro; Matthew R Benton; Marion Kirk; Landon S Wilson; Jeevan K Prasain; Nigel Botting; Stephen Barnes; Victor Darley-Usmar; Rakesh P Patel
Neutrophil myeloperoxidase chlorinates and nitrates soy isoflavones and enhances their antioxidant properties.
Free radical biology & medicine 2003;35(11):1417-30.
2003: Erin K Ceaser; Anup Ramachandran; Anna-Liisa Levonen; Victor Darley-Usmar
Oxidized low-density lipoprotein and 15-deoxy-delta 12,14-PGJ2 increase mitochondrial complex I activity in endothelial cells.
American journal of physiology. Heart and circulatory physiology 2003;285(6):H2298-308.
2003: Tracy L D'Alessandro; Jeevan K Prasain; M R Benton; Nigel Botting; Ray Moore; Victor Darley-Usmar; Rakesh Patel; Stephen Barnes
Polyphenols, inflammatory response, and cancer prevention: chlorination of isoflavones by human neutrophils.
The Journal of nutrition 2003;133(11 Suppl 1):3773S-3777S.
2003: Sruti Shiva; Victor Darley-Usmar
Control of the nitric oxide-cytochrome c oxidase signaling pathway under pathological and physiological conditions.
IUBMB life 2003;55(10-11):585-90.
2003: Paul S Brookes; David Kraus; Sruti Shiva; Jeannette E Doeller; Maria Cecilia Barone; Rakesh P Patel; Jack R Lancaster; Victor Darley-Usmar
Control of mitochondrial respiration by NO*, effects of low oxygen and respiratory state.
The Journal of biological chemistry 2003;278(34):31603-9.
2003: Maria Cecilia Barone; Victor Darley-Usmar; Paul S Brookes
Reversible inhibition of cytochrome c oxidase by peroxynitrite proceeds through ascorbate-dependent generation of nitric oxide.
The Journal of biological chemistry 2003;278(30):27520-4.
2003: Jeevan K Prasain; Rakesh Patel; Marion Kirk; Landon Wilson; Nigel Botting; Victor Darley-Usmar; Stephen Barnes
Mass spectrometric methods for the analysis of chlorinated and nitrated isoflavonoids: a novel class of biological metabolites.
Journal of mass spectrometry : JMS 2003;38(7):764-71.
2003: Aparna Venkatraman; Sruti Shiva; Ashley J Davis; Shannon M Bailey; Paul S Brookes; Victor Darley-Usmar
Chronic alcohol consumption increases the sensitivity of rat liver mitochondrial respiration to inhibition by nitric oxide.
Hepatology (Baltimore, Md.) 2003;38(1):141-7.
2003: Trudy L Cornwell; Erin K Ceaser; Jie Li; Kevin L Marrs; Victor Darley-Usmar; Rakesh P Patel
S-nitrosothiols inhibit uterine smooth muscle cell proliferation independent of metabolism to NO and cGMP formation.
American journal of physiology. Cell physiology 2003;284(6):C1516-24.
2003: Dale A Dickinson; Douglas R Moellering; Karen E Iles; Rakesh P Patel; Anna-Liisa Levonen; Amanda F Wigley; Victor Darley-Usmar; Henry Jay Forman
Cytoprotection against oxidative stress and the regulation of glutathione synthesis.
Biological chemistry 2003;384(4):527-37.
2002: Anup Ramachandran; Anna-Liisa Levonen; Paul S Brookes; Erin K Ceaser; Sruti Shiva; Maria Cecilia Barone; Victor Darley-Usmar
Mitochondria, nitric oxide, and cardiovascular dysfunction.
Free radical biology & medicine 2002;33(11):1465-74.
2002: Chris E Cooper; Rakesh P Patel; Paul S Brookes; Victor Darley-Usmar
Nanotransducers in cellular redox signaling: modification of thiols by reactive oxygen and nitrogen species.
Trends in biochemical sciences 2002;27(10):489-92.
2002: Paul S Brookes; Anna-Liisa Levonen; Sruti Shiva; Paolo Sarti; Victor Darley-Usmar
Mitochondria: regulators of signal transduction by reactive oxygen and nitrogen species.
Free radical biology & medicine 2002;33(6):755-64.
2002: Catherine Fenster; Roland L Weinsier; Victor Darley-Usmar; Rakesh P Patel
Obesity, aerobic exercise, and vascular disease: the role of oxidant stress.
Obesity research 2002;10(9):964-8.
2002: Paul S Brookes; Anita Pinner; Anup Ramachandran; Lori Coward; Stephen Barnes; Helen Kim; Victor Darley-Usmar
High throughput two-dimensional blue-native electrophoresis: a tool for functional proteomics of mitochondria and signaling complexes.
Proteomics 2002;2(8):969-77.
2002: Paul S Brookes; Stanley B Digerness; Dale A Parks; Victor Darley-Usmar
Mitochondrial function in response to cardiac ischemia-reperfusion after oral treatment with quercetin.
Free radical biology & medicine 2002;32(11):1220-8.
2002: Anup Ramachandran; Douglas R Moellering; Erin K Ceaser; Sruti Shiva; Jun Xu; Victor Darley-Usmar
Inhibition of mitochondrial protein synthesis results in increased endothelial cell susceptibility to nitric oxide-induced apoptosis.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(10):6643-8.
2002: Tsu-Kung Lin; Gillian Hughes; Aleksandra Muratovska; Frances H Blaikie; Paul S Brookes; Victor Darley-Usmar; Robin A J Smith; Michael P Murphy
Specific modification of mitochondrial protein thiols in response to oxidative stress: a proteomics approach.
The Journal of biological chemistry 2002;277(19):17048-56.
2002: Shuxia Wang; Sruti Shiva; Maria H Poczatek; Victor Darley-Usmar; Joanne E Murphy-Ullrich
Nitric oxide and cGMP-dependent protein kinase regulation of glucose-mediated thrombospondin 1-dependent transforming growth factor-beta activation in mesangial cells.
The Journal of biological chemistry 2002;277(12):9880-8.
2002: Anup Ramachandran; Douglas R Moellering; Young-Mi Go; Sruti Shiva; Anna-Liisa Levonen; Hanjoong Jo; Rakesh P Patel; Sampath Parthasarathy; Victor Darley-Usmar
Activation of c-Jun N-terminal kinase and apoptosis in endothelial cells mediated by endogenous generation of hydrogen peroxide.
Biological chemistry 2002;383(3-4):693-701.
2002: Paul S Brookes; Victor Darley-Usmar
Hypothesis: the mitochondrial NO(*) signaling pathway, and the transduction of nitrosative to oxidative cell signals: an alternative function for cytochrome C oxidase.
Free radical biology & medicine 2002;32(4):370-4.
2002: Douglas R Moellering; Anna-Liisa Levonen; Young-Mi Go; Rakesh P Patel; Dale A Dickinson; Henry Jay Forman; Victor Darley-Usmar
Induction of glutathione synthesis by oxidized low-density lipoprotein and 1-palmitoyl-2-arachidonyl phosphatidylcholine: protection against quinone-mediated oxidative stress.
The Biochemical journal 2002;362(Pt 1):51-9.
2002: Paul S Brookes; Sruti Shiva; Rakesh P Patel; Victor Darley-Usmar
Measurement of mitochondrial respiratory thresholds and the control of respiration by nitric oxide.
Methods in enzymology 2002;359():305-19.
2001: Rakesh P Patel; Brenda J Boersma; Jack H Crawford; Neil Hogg; Marion Kirk; B Kalyanaraman; Dale A Parks; Stephen Barnes; Victor Darley-Usmar
Antioxidant mechanisms of isoflavones in lipid systems: paradoxical effects of peroxyl radical scavenging.
Free radical biology & medicine 2001;31(12):1570-81.
2001: Young-Mi Go; Anna-Liisa Levonen; Douglas R Moellering; Anup Ramachandran; Rakesh P Patel; Hanjoong Jo; Victor Darley-Usmar
Endothelial NOS-dependent activation of c-Jun NH(2)- terminal kinase by oxidized low-density lipoprotein.
American journal of physiology. Heart and circulatory physiology 2001;281(6):H2705-13.
2001: L Dai; Paul S Brookes; Victor Darley-Usmar; Peter G Anderson
Bioenergetics in cardiac hypertrophy: mitochondrial respiration as a pathological target of NO*.
American journal of physiology. Heart and circulatory physiology 2001;281(6):H2261-9.
2001: Anna-Liisa Levonen; Dale A Dickinson; Douglas R Moellering; R T Mulcahy; Henry Jay Forman; Victor Darley-Usmar
Biphasic effects of 15-deoxy-delta(12,14)-prostaglandin J(2) on glutathione induction and apoptosis in human endothelial cells.
Arteriosclerosis, thrombosis, and vascular biology 2001;21(11):1846-51.
2001: Y M Go; Yong BOO; H Park; MC Maland; R Patel; K A Pritchard; Y Fujio; K Walsh; Victor Darley-Usmar; Hanjoong Jo
Protein kinase B/Akt activates c-Jun NH(2)-terminal kinase by increasing NO production in response to shear stress.
Journal of applied physiology (Bethesda, Md. : 1985) 2001;91(4):1574-81.
2001: C Zhang; Rakesh Patel; Jason P Eiserich; Fen Zhou; Stacey S Kelpke; W Ma; Dale A Parks; Victor Darley-Usmar; C Roger White
Endothelial dysfunction is induced by proinflammatory oxidant hypochlorous acid.
American journal of physiology. Heart and circulatory physiology 2001;281(4):H1469-75.
2001: R Marley; Rakesh P Patel; N Orie; Erin K Ceaser; Victor Darley-Usmar; K Moore
Formation of nanomolar concentrations of S-nitroso-albumin in human plasma by nitric oxide.
Free radical biology & medicine 2001;31(5):688-96.
2001: Brenda J Boersma; Stephen Barnes; Marion Kirk; C C Wang; Michelle Smith; Helen Kim; Jun Xu; Rakesh Patel; Victor Darley-Usmar
Soy isoflavonoids and cancer -- metabolism at the target site.
Mutation research 2001;480-481():121-7.
2001: C Zhang; C Reiter; Jason P Eiserich; Brenda J Boersma; Dale A Parks; Joseph S Beckman; Stephen Barnes; Marion Kirk; Stephan Baldus; Victor Darley-Usmar; C Roger White
L-arginine chlorination products inhibit endothelial nitric oxide production.
The Journal of biological chemistry 2001;276(29):27159-65.
2001: Sruti Shiva; Paul S Brookes; Rakesh P Patel; Peter G Anderson; Victor Darley-Usmar
Nitric oxide partitioning into mitochondrial membranes and the control of respiration at cytochrome c oxidase.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(13):7212-7.
2001: Anna-Liisa Levonen; Rakesh P Patel; Paul S Brookes; Young-Mi Go; Hanjoong Jo; Sampath Parthasarathy; Peter G Anderson; Victor Darley-Usmar
Mechanisms of cell signaling by nitric oxide and peroxynitrite: from mitochondria to MAP kinases.
Antioxidants & redox signaling 2001;3(2):215-29.
2001: Ralf Binsack; Brenda J Boersma; Rakesh P Patel; Marion Kirk; C Roger White; Victor Darley-Usmar; Stephen Barnes; Fen Zhou; Dale A Parks
Enhanced antioxidant activity after chlorination of quercetin by hypochlorous acid.
Alcoholism, clinical and experimental research 2001;25(3):434-43.
2001: Brenda J Boersma; Rakesh P Patel; Nigel Botting; C Roger White; D Parks; Stephen Barnes; Victor Darley-Usmar
Formation of novel bioactive metabolites from the reactions of pro-inflammatory oxidants with polyphenolics.
BioFactors (Oxford, England) 2001;15(2-4):79-81.
2001: Paul S Brookes; J Zhang; L Dai; F Zhou; Dale A Parks; Victor Darley-Usmar; Peter G Anderson
Increased sensitivity of mitochondrial respiration to inhibition by nitric oxide in cardiac hypertrophy.
Journal of molecular and cellular cardiology 2001;33(1):69-82.
2000: Maria H Poczatek; Christian Hugo; Victor Darley-Usmar; Joanne E Murphy-Ullrich
Glucose stimulation of transforming growth factor-beta bioactivity in mesangial cells is mediated by thrombospondin-1.
The American journal of pathology 2000;157(4):1353-63.
2000: Rakesh P Patel; Anna-Liisa Levonen; Jack H Crawford; Victor Darley-Usmar
Mechanisms of the pro- and anti-oxidant actions of nitric oxide in atherosclerosis.
Cardiovascular research 2000;47(3):465-74.
2000: Paul S Brookes; E P Salinas; K Darley-Usmar; Jason P Eiserich; Bruce Freeman; Victor Darley-Usmar; Peter G Anderson
Concentration-dependent effects of nitric oxide on mitochondrial permeability transition and cytochrome c release.
The Journal of biological chemistry 2000;275(27):20474-9.
2000: Rakesh P Patel; Douglas R Moellering; J Murphy-Ullrich; Hanjoong Jo; J S Beckman; Victor Darley-Usmar
Cell signaling by reactive nitrogen and oxygen species in atherosclerosis.
Free radical biology & medicine 2000;28(12):1780-94.
2000: C E Thomas; Victor Darley-Usmar
Forum on therapeutic applications of reactive oxygen and nitrogen species in human disease.
Free radical biology & medicine 2000;28(10):1449-50.
2000: Stephen Barnes; Helen Kim; Victor Darley-Usmar; Rakesh Patel; Jun Xu; Brenda J Boersma; M Luo
Beyond ERalpha and ERbeta: estrogen receptor binding is only part of the isoflavone story.
The Journal of nutrition 2000;130(3):656S-7S.
2000: XR Pan-Zhou; L Cui; XJ Zhou; Jean-Pierre Sommadossi; Victor Darley-Usmar
Differential effects of antiretroviral nucleoside analogs on mitochondrial function in HepG2 cells.
Antimicrobial agents and chemotherapy 2000;44(3):496-503.
2000: Victor Darley-Usmar; P E Starke-Reed
Antioxidants: strategies for interventions in aging and age-related diseases. A workshop sponsored by the National Institute on Aging and by the Office of Dietary Supplements.
Antioxidants & redox signaling 2000;2(3):375-7.
2000: Stephen Barnes; Brenda J Boersma; Rakesh Patel; Marion Kirk; Victor Darley-Usmar; Helen Kim; Jun Xu
Isoflavonoids and chronic disease: mechanisms of action.
BioFactors (Oxford, England) 2000;12(1-4):209-15.
1999: Stanley B Digerness; K D Harris; J W Kirklin; Ferdinand Urthaler; Liliana Viera; Joseph S Beckman; Victor Darley-Usmar
Peroxynitrite irreversibly decreases diastolic and systolic function in cardiac muscle.
Free radical biology & medicine 1999;27(11-12):1386-92.
1999: Young-Mi Go; Rakesh P Patel; MC Maland; H Park; J S Beckman; Victor Darley-Usmar; Hanjoong Jo
Evidence for peroxynitrite as a signaling molecule in flow-dependent activation of c-Jun NH(2)-terminal kinase.
The American journal of physiology 1999;277(4 Pt 2):H1647-53.
1999: Brenda J Boersma; Rakesh P Patel; Marion Kirk; P L Jackson; Donald D Muccio; Victor Darley-Usmar; Stephen Barnes
Chlorination and nitration of soy isoflavones.
Archives of biochemistry and biophysics 1999;368(2):265-75.
1999: Valerie B O'Donnell; Kenneth B Taylor; Sampath Parthasarathy; H Kühn; Doris Koesling; Andreas Friebe; Allison Bloodsworth; Victor Darley-Usmar; Bruce Freeman
15-Lipoxygenase catalytically consumes nitric oxide and impairs activation of guanylate cyclase.
The Journal of biological chemistry 1999;274(29):20083-91.
1999: Rakesh P Patel; Neil Hogg; Netanya Y Spencer; B Kalyanaraman; Sadis Matalon; Victor Darley-Usmar
Biochemical characterization of human S-nitrosohemoglobin. Effects on oxygen binding and transnitrosation.
The Journal of biological chemistry 1999;274(22):15487-92.
1999: Rakesh P Patel; Joanne McAndrew; Hassan Sellak; C R White; Hanjoong Jo; Bruce Freeman; Victor Darley-Usmar
Biological aspects of reactive nitrogen species.
Biochimica et biophysica acta 1999;1411(2-3):385-400.
1999: Douglas R Moellering; Joanne McAndrew; Hanjoong Jo; Victor Darley-Usmar
Effects of pyrrolidine dithiocarbamate on endothelial cells: protection against oxidative stress.
Free radical biology & medicine 1999;26(9-10):1138-45.
1999: Douglas R Moellering; J Mc Andrew; Rakesh P Patel; Henry Jay Forman; R T Mulcahy; Hanjoong Jo; Victor Darley-Usmar
The induction of GSH synthesis by nanomolar concentrations of NO in endothelial cells: a role for gamma-glutamylcysteine synthetase and gamma-glutamyl transpeptidase.
FEBS letters 1999;448(2-3):292-6.
1999: R P Patel; J Crawford; B Boersma; S Barnes; Victor Darley-Usmar
Antioxidant properties of phytoestrogens.
Journal of medicinal food 1999;2(3-4):163-6.
1999: Rakesh P Patel; Victor Darley-Usmar
Molecular mechanisms of the copper dependent oxidation of low-density lipoprotein.
Free radical research 1999;30(1):1-9.
1999: Valerie B O'Donnell; Jason P Eiserich; Allison Bloodsworth; Phillip Chumley; Marion Kirk; Stephen Barnes; Victor Darley-Usmar; Bruce Freeman
Nitration of unsaturated fatty acids by nitric oxide-derived reactive species.
Methods in enzymology 1999;301():454-70.
1999: C Roger White; Rakesh P Patel; Victor Darley-Usmar
Nitric oxide donor generation from reactions of peroxynitrite.
Methods in enzymology 1999;301():288-98.
1999: Valerie B O'Donnell; Jason P Eiserich; Phillip Chumley; Michael J Jablonsky; N Rama Krishna; Marion Kirk; Stephen Barnes; Victor Darley-Usmar; Bruce Freeman
Nitration of unsaturated fatty acids by nitric oxide-derived reactive nitrogen species peroxynitrite, nitrous acid, nitrogen dioxide, and nitronium ion.
Chemical research in toxicology 1999;12(1):83-92.
1998: Kevin P Moore; Stephen Geoffrey Holt; R P Patel; Dimitri A Svistunenko; W Zackert; David W Goodier; Brandon J Reeder; M Clozel; R Anand; Chris E Cooper; J D Morrow; Michael T Wilson; Victor Darley-Usmar; L J Roberts
A causative role for redox cycling of myoglobin and its inhibition by alkalinization in the pathogenesis and treatment of rhabdomyolysis-induced renal failure.
The Journal of biological chemistry 1998;273(48):31731-7.
1998: A S Brown; Maria Moro; J M Masse; Elisabeth M Cramer; M Radomski; Victor Darley-Usmar
Nitric oxide-dependent and independent effects on human platelets treated with peroxynitrite.
Cardiovascular research 1998;40(2):380-8.
1998: Young-Mi Go; H Park; MC Maland; Victor Darley-Usmar; B Stoyanov; Reinhard Wetzker; Hanjoong Jo
Phosphatidylinositol 3-kinase gamma mediates shear stress-dependent activation of JNK in endothelial cells.
The American journal of physiology 1998;275(5 Pt 2):H1898-904.
1998: Douglas R Moellering; Joanne McAndrew; Rakesh P Patel; Trudy L Cornwell; Thomas M Lincoln; Xu Cao; J L Messina; Henry Jay Forman; Hanjoong Jo; Victor Darley-Usmar
Nitric oxide-dependent induction of glutathione synthesis through increased expression of gamma-glutamylcysteine synthetase.
Archives of biochemistry and biophysics 1998;358(1):74-82.
1998: Kelly A Skinner; C Roger White; R Patel; Sidhartha Tan; Stephen Barnes; Marion Kirk; Victor Darley-Usmar; Dale A Parks
Nitrosation of uric acid by peroxynitrite. Formation of a vasoactive nitric oxide donor.
The Journal of biological chemistry 1998;273(38):24491-7.
1998: R White; J Crow; N Spear; S Thomas; R Patel; I Green; J Beckman; Victor Darley-Usmar
Making and working with peroxynitrite.
Methods in molecular biology (Clifton, N.J.) 1998;100():215-30.
1997: Valerie B O'Donnell; Phillip Chumley; Neil Hogg; Allison Bloodsworth; Victor Darley-Usmar; Bruce Freeman
Nitric oxide inhibition of lipid peroxidation: kinetics of reaction with lipid peroxyl radicals and comparison with alpha-tocopherol.
Biochemistry 1997;36(49):15216-23.
1997: C R White; Douglas R Moellering; Rakesh P Patel; M Kirk; S Barnes; Victor Darley-Usmar
Formation of the NO donors glyceryl mononitrate and glyceryl mononitrite from the reaction of peroxynitrite with glycerol.
The Biochemical journal 1997;328 ( Pt 2)():517-24.
1997: C Roger White; Victor Darley-Usmar; Suzanne Oparil
No role for NO in estrogen-mediated vasoprotection?
Circulation 1997;96(9):2769-71.
1997: Joanne McAndrew; R P Patel; Hanjoong Jo; Trudy L Cornwell; T Lincoln; Douglas R Moellering; C R White; S Matalon; Victor Darley-Usmar
The interplay of nitric oxide and peroxynitrite with signal transduction pathways: implications for disease.
Seminars in perinatology 1997;21(5):351-66.
1997: C Roger White; Jonathan Shelton; SJ Chen; Victor Darley-Usmar; L Allen; C Nabors; Paul W Sanders; Yiu-Fai Chen; Suzanne Oparil
Estrogen restores endothelial cell function in an experimental model of vascular injury.
Circulation 1997;96(5):1624-30.
1997: Victor Darley-Usmar; Joanne McAndrew; R Patel; Douglas R Moellering; T M Lincoln; Hanjoong Jo; Trudy L Cornwell; Stanley B Digerness; C R White
Nitric oxide, free radicals and cell signalling in cardiovascular disease.
Biochemical Society transactions 1997;25(3):925-9.
1997: J Torres; N Davies; Victor Darley-Usmar; M T Wilson
The inhibition of cytochrome c oxidase by nitric oxide using S-nitrosoglutathione.
Journal of inorganic biochemistry 1997;66(3):207-12.
1997: C R White; Victor Darley-Usmar; Suzanne Oparil
Gender and cardiovascular disease recent insights.
Trends in cardiovascular medicine 1997;7(3):94-100.
1997: Victor Darley-Usmar; R White
Disruption of vascular signalling by the reaction of nitric oxide with superoxide: implications for cardiovascular disease.
Experimental physiology 1997;82(2):305-16.
1997: Rakesh P Patel; Dimitri A Svistunenko; Michael T Wilson; Victor Darley-Usmar
Reduction of Cu(II) by lipid hydroperoxides: implications for the copper-dependent oxidation of low-density lipoprotein.
The Biochemical journal 1997;322 ( Pt 2)():425-33.
1996: Rakesh P Patel; Ulf Diczfalusy; S Dzeletovic; Michael T Wilson; Victor Darley-Usmar
Formation of oxysterols during oxidation of low density lipoprotein by peroxynitrite, myoglobin, and copper.
Journal of lipid research 1996;37(11):2361-71.
1996: C Roger White; Victor Darley-Usmar; William Berrington; M McAdams; J Z Gore; John A Thompson; Dale A Parks; Margaret M Tarpey; Bruce Freeman
Circulating plasma xanthine oxidase contributes to vascular dysfunction in hypercholesterolemic rabbits.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(16):8745-9.
1996: Rakesh P Patel; Dimitri A Svistunenko; Victor Darley-Usmar; M C Symons; Michael T Wilson
Redox cycling of human methaemoglobin by H2O2 yields persistent ferryl iron and protein based radicals.
Free radical research 1996;25(2):117-23.
1996: Homero Rubbo; Victor Darley-Usmar; Bruce Freeman
Nitric oxide regulation of tissue free radical injury.
Chemical research in toxicology 1996;9(5):809-20.
1996: G D Jones; L Russell; Victor Darley-Usmar; D Stone; Michael T Wilson
Role of lipid hydroperoxides in the activation of 15-lipoxygenase.
Biochemistry 1996;35(22):7197-203.
1996: Victor Darley-Usmar; Barry Halliwell
Blood radicals: reactive nitrogen species, reactive oxygen species, transition metal ions, and the vascular system.
Pharmaceutical research 1996;13(5):649-62.
1996: ignacio lizasoain; Maria Moro; R G Knowles; Victor Darley-Usmar; S Moncada
Nitric oxide and peroxynitrite exert distinct effects on mitochondrial respiration which are differentially blocked by glutathione or glucose.
The Biochemical journal 1996;314 ( Pt 3)():877-80.
1996: D R Smith; D Stone; Victor Darley-Usmar
Stimulation of mitochondrial oxygen consumption in isolated cardiomyocytes after hypoxia-reoxygenation.
Free radical research 1996;24(3):159-66.
1996: Maria Moro; R J Russel; S Cellek; ignacio lizasoain; Y Su; Victor Darley-Usmar; M W Radomski; S Moncada
cGMP mediates the vascular and platelet actions of nitric oxide: confirmation using an inhibitor of the soluble guanylyl cyclase.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(4):1480-5.
1996: V J O'Leary; L Tilling; G Fleetwood; D Stone; Victor Darley-Usmar
The resistance of low density lipoprotein to oxidation promoted by copper and its use as an index of antioxidant therapy.
Atherosclerosis 1996;119(2):169-79.
1996: V J O'Leary; A Graham; D Stone; Victor Darley-Usmar
Oxidation of human low-density lipoprotein by soybean 15-lipoxygenase in combination with copper (II) or met-myoglobin.
Free radical biology & medicine 1996;20(4):525-32.
1996: Rakesh P Patel; Victor Darley-Usmar
Using peroxynitrite as oxidant with low-density lipoprotein.
Methods in enzymology 1996;269():375-84.
1995: J Torres; Victor Darley-Usmar; Michael T Wilson
Inhibition of cytochrome c oxidase in turnover by nitric oxide: mechanism and implications for control of respiration.
The Biochemical journal 1995;312 ( Pt 1)():169-73.
1995: Maria Moro; Victor Darley-Usmar; ignacio lizasoain; Y Su; R G Knowles; M W Radomski; S Moncada
The formation of nitric oxide donors from peroxynitrite.
British journal of pharmacology 1995;116(3):1999-2004.
1995: Victor Darley-Usmar; H Wiseman; Barry Halliwell
Nitric oxide and oxygen radicals: a question of balance.
FEBS letters 1995;369(2-3):131-5.
1995: K P Moore; Victor Darley-Usmar; J Morrow; L Jackson Roberts
Formation of F2-isoprostanes during oxidation of human low-density lipoprotein and plasma by peroxynitrite.
Circulation research 1995;77(2):335-41.
1995: Balaraman Kalyanaraman; Victor Darley-Usmar; A Struck; Neil Hogg; Sampath Parthasarathy
Role of apolipoprotein B-derived radical and alpha-tocopheroxyl radical in peroxidase-dependent oxidation of low density lipoprotein.
Journal of lipid research 1995;36(5):1037-45.
1995: M Iwatsuki; Etsuo Niki; D Stone; Victor Darley-Usmar
Alpha-tocopherol mediated peroxidation in the copper (II) and met myoglobin induced oxidation of human low density lipoprotein: the influence of lipid hydroperoxides.
FEBS letters 1995;360(3):271-6.
1995: K P Moore; Victor Darley-Usmar; J Morrow; L Jackson Roberts
Formation of F2-isoprostanes during the oxidation of human low density lipoprotein by peroxynitrite.
Advances in prostaglandin, thromboxane, and leukotriene research 1995;23():225-7.
1994: L M Villa; E Salas; Victor Darley-Usmar; M W Radomski; S Moncada
Peroxynitrite induces both vasodilatation and impaired vascular relaxation in the isolated perfused rat heart.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(26):12383-7.
1994: Albert van der Vliet; D Smith; C A O'Neill; H Kaur; Victor Darley-Usmar; Carroll E Cross; Barry Halliwell
Interactions of peroxynitrite with human plasma and its constituents: oxidative damage and antioxidant depletion.
The Biochemical journal 1994;303 ( Pt 1)():295-301.
1994: N Hogg; Catherine Rice-Evans; Victor Darley-Usmar; M T Wilson; George Paganga; LC Bourne
The role of lipid hydroperoxides in the myoglobin-dependent oxidation of LDL.
Archives of biochemistry and biophysics 1994;314(1):39-44.
1994: P Sarti; N Hogg; Victor Darley-Usmar; Maria T Sanna; M T Wilson
The oxidation of cytochrome-c oxidase vesicles by hemoglobin.
Biochimica et biophysica acta 1994;1208(1):38-44.
1994: Maria Moro; Victor Darley-Usmar; D A Goodwin; N G Read; R Zamora-Pino; M Feelisch; M W Radomski; S Moncada
Paradoxical fate and biological action of peroxynitrite on human platelets.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(14):6702-6.
1994: Michael W J Cleeter; J Mark Cooper; Victor Darley-Usmar; S Moncada; Anthony H V Schapira
Reversible inhibition of cytochrome c oxidase, the terminal enzyme of the mitochondrial respiratory chain, by nitric oxide. Implications for neurodegenerative diseases.
FEBS letters 1994;345(1):50-4.
1994: J A Swain; Victor Darley-Usmar; John M C Gutteridge
Peroxynitrite releases copper from caeruloplasmin: implications for atherosclerosis.
FEBS letters 1994;342(1):49-52.
1993: N Gotoh; A Graham; E Nikl; Victor Darley-Usmar
Inhibition of glutathione synthesis increases the toxicity of oxidized low-density lipoprotein to human monocytes and macrophages.
The Biochemical journal 1993;296 ( Pt 1)():151-4.
1993: A Graham; N Hogg; B Kalyanaraman; V O'Leary; Victor Darley-Usmar; S Moncada
Peroxynitrite modification of low-density lipoprotein leads to recognition by the macrophage scavenger receptor.
FEBS letters 1993;330(2):181-5.
1993: S P Allen; Victor Darley-Usmar; J G McCormack; D Stone
Changes in mitochondrial matrix free calcium in perfused rat hearts subjected to hypoxia-reoxygenation.
Journal of molecular and cellular cardiology 1993;25(8):949-58.
1993: N Hogg; Victor Darley-Usmar; M T Wilson; S Moncada
The oxidation of alpha-tocopherol in human low-density lipoprotein by the simultaneous generation of superoxide and nitric oxide.
FEBS letters 1993;326(1-3):199-203.
1993: D Smith; V J O'Leary; Victor Darley-Usmar
The role of alpha-tocopherol as a peroxyl radical scavenger in human low density lipoprotein.
Biochemical pharmacology 1993;45(11):2195-201.
1993: V O'Leary; A Graham; Victor Darley-Usmar; D Stone
The effect of lipid hydroperoxides on the copper dependent oxidation of low density lipoprotein.
Biochemical Society transactions 1993;21(2):89S.
1993: N Hogg; Victor Darley-Usmar; A Graham; S Moncada
Peroxynitrite and atherosclerosis.
Biochemical Society transactions 1993;21(2):358-62.
1992: Balaraman Kalyanaraman; Victor Darley-Usmar; J Wood; Joy Joseph; Sampath Parthasarathy
Synergistic interaction between the probucol phenoxyl radical and ascorbic acid in inhibiting the oxidation of low density lipoprotein.
The Journal of biological chemistry 1992;267(10):6789-95.
1992: V J O'Leary; Victor Darley-Usmar; L J Russell; D Stone
Pro-oxidant effects of lipoxygenase-derived peroxides on the copper-initiated oxidation of low-density lipoprotein.
The Biochemical journal 1992;282 ( Pt 3)():631-4.
1992: N Hogg; Victor Darley-Usmar; Michael T Wilson; S Moncada
Production of hydroxyl radicals from the simultaneous generation of superoxide and nitric oxide.
The Biochemical journal 1992;281 ( Pt 2)():419-24.
1992: Michael Yeadon; D Wilkinson; Victor Darley-Usmar; V J O'Leary; A N Payne
Mechanisms contributing to ozone-induced bronchial hyperreactivity in guinea-pigs.
Pulmonary pharmacology 1992;5(1):39-50.
1992: Victor Darley-Usmar; N Hogg; V J O'Leary; M T Wilson; S Moncada
The simultaneous generation of superoxide and nitric oxide can initiate lipid peroxidation in human low density lipoprotein.
Free radical research communications 1992;17(1):9-20.
1991: Victor Darley-Usmar; A Severn; V J O'Leary; M Rogers
Treatment of macrophages with oxidized low-density lipoprotein increases their intracellular glutathione content.
The Biochemical journal 1991;278 ( Pt 2)():429-34.
1991: W Jessup; Victor Darley-Usmar; V O'Leary; S Bedwell
5-Lipoxygenase is not essential in macrophage-mediated oxidation of low-density lipoprotein.
The Biochemical journal 1991;278 ( Pt 1)():163-9.
1991: L Hardy; J B Clark; Victor Darley-Usmar; D R Smith; D Stone
Reoxygenation-dependent decrease in mitochondrial NADH:CoQ reductase (Complex I) activity in the hypoxic/reoxygenated rat heart.
The Biochemical journal 1991;274 ( Pt 1)():133-7.
1991: Victor Darley-Usmar; D Stone; D Smith; J F Martin
Mitochondria, oxygen and reperfusion damage.
Annals of medicine 1991;23(5):583-8.
1990: Victor Darley-Usmar; R Lelchuk; V J O'Leary; M Knowles; M V Rogers; A Severn
Oxidation of low-density lipoprotein and macrophage derived foam cells.
Biochemical Society transactions 1990;18(6):1064-6.
1990: Victor Darley-Usmar; D R Smith; V J O'Leary; D Stone; D L Hardy; J B Clark
Hypoxia-reoxygenation induced damage in the myocardium: the role of mitochondria.
Biochemical Society transactions 1990;18(4):526-8.
1990: D L Hardy; John B Clark; Victor Darley-Usmar; D R Smith
Reoxygenation of the hypoxic myocardium causes a mitochondrial complex I defect.
Biochemical Society transactions 1990;18(4):549.
1989: D Stone; Victor Darley-Usmar; D R Smith; V O'Leary
Hypoxia-reoxygenation induced increase in cellular Ca2+ in myocytes and perfused hearts: the role of mitochondria.
Journal of molecular and cellular cardiology 1989;21(10):963-73.
1989: J Sato; Victor Darley-Usmar; H Fukutomi; T Osuga; K Fukao
The exocrine secretions of the grafted pancreas.
Transplantation proceedings 1989;21(3):3449-51.
1989: Mark A Birch-Machin; I M Shepherd; N J Watmough; H S Sherratt; K Bartlett; Victor Darley-Usmar; D W Milligan; R J Welch; A Aynsley-Green; Douglass M Turnbull
Fatal lactic acidosis in infancy with a defect of complex III of the respiratory chain.
Pediatric research 1989;25(5):553-9.
1989: Victor Darley-Usmar; A Hersey; L G Garland
A method for the comparative assessment of antioxidants as peroxyl radical scavengers.
Biochemical pharmacology 1989;38(9):1465-9.
1989: Victor Darley-Usmar; V O'Leary; D Stone
The glutathione status of perfused rat hearts subjected to hypoxia and reoxygenation: the oxygen paradox.
Free radical research communications 1989;6(4):261-7.
1989: Victor Darley-Usmar; D Stone; D R Smith
Oxygen and reperfusion damage: an overview.
Free radical research communications 1989;7(3-6):247-54.
1987: Victor Darley-Usmar
The molecular aetiology of human mitochondrial myopathies.
Biochemical Society transactions 1987;15(1):102-3.
1986: J Satoh; Victor Darley-Usmar; H Kashimura; H Fukutomi; K Anan; T Ohsuga
Analysis of pure pancreatic juice proteins by two-dimensional gel electrophoresis in cases of pancreatic cancer.
Gastroenterologia Japonica 1986;21(6):623-9.
1986: Victor Darley-Usmar; M Watanabe; Y Uchiyama; I Kondo; N G Kennaway; L Gronke; H Hamaguchi
Mitochondrial myopathy: tissue-specific expression of a defect in ubiquinol-cytochrome c reductase.
Clinica chimica acta; international journal of clinical chemistry 1986;158(3):253-61.
1985: Victor Darley-Usmar; M Watanabe
Analyses of muscle proteins in a patient with a mitochondrial myopathy.
Journal of biochemistry 1985;97(6):1767-75.
1984: N G Kennaway; N R Buist; Victor Darley-Usmar; A Papadimitriou; S Dimauro; R I Kelley; R A Capaldi; N K Blank; A D'Agostino
Lactic acidosis and mitochondrial myopathy associated with deficiency of several components of complex III of the respiratory chain.
Pediatric research 1984;18(10):991-9.
1984: S Eleff; N G Kennaway; N R Buist; Victor Darley-Usmar; R A Capaldi; William Bank; Britton Chance
31P NMR study of improvement in oxidative phosphorylation by vitamins K3 and C in a patient with a defect in electron transport at complex III in skeletal muscle.
Proceedings of the National Academy of Sciences of the United States of America 1984;81(11):3529-33.
1984: Victor Darley-Usmar; G Georgevich; R A Capaldi
Reaction of thionitrobenzoate-modified yeast cytochrome c with monomeric and dimeric forms of beef heart cytochrome c oxidase.
FEBS letters 1984;166(1):131-5.
1983: F Malatesta; Victor Darley-Usmar; C de Jong; L J Prochaska; R Bisson; R A Capaldi; G C Steffens; Gerhard Buse
Arrangement of subunit IV in beef heart cytochrome c oxidase probed by chemical labeling and protease digestion experiments.
Biochemistry 1983;22(19):4405-11.
1983: Victor Darley-Usmar; N G Kennaway; N R Buist; R A Capaldi
Deficiency in ubiquinone cytochrome c reductase in a patient with mitochondrial myopathy and lactic acidosis.
Proceedings of the National Academy of Sciences of the United States of America 1983;80(16):5103-6.
1983: R A Capaldi; F Malatesta; Victor Darley-Usmar
Structure of cytochrome c oxidase.
Biochimica et biophysica acta 1983;726(2):135-48.
1983: G Georgevich; Victor Darley-Usmar; F Malatesta; R A Capaldi
Electron transfer in monomeric forms of beef and shark heart cytochrome c oxidase.
Biochemistry 1983;22(6):1317-22.
1982: F Millett; Victor Darley-Usmar; R A Capaldi
Cytochrome c is cross-linked to subunit II of cytochrome c oxidase by a water-soluble carbodiimide.
Biochemistry 1982;21(16):3857-62.
1982: R A Capaldi; Victor Darley-Usmar; S Fuller; F Millett
Structural and functional features of the interaction of cytochrome c with complex III and cytochrome c oxidase.
FEBS letters 1982;138(1):1-7.
1981: Victor Darley-Usmar; R A Capaldi; M T Wilson
Identification of cysteines in subunit II as ligands to the redox centers of bovine cytochrome c oxidase.
Biochemical and biophysical research communications 1981;103(4):1223-30.
1981: Victor Darley-Usmar; S D Fuller
Mr-values of mature subunits I and III of beef heart cytochrome c oxidase in relationship to nucleotide sequences of their genes.
FEBS letters 1981;135(1):164-6.
1981: S D Fuller; Victor Darley-Usmar; R A Capaldi
Covalent complex between yeast cytochrome c and beef heart cytochrome c oxidase which is active in electron transfer.
Biochemistry 1981;20(24):7046-53.
1981: Victor Darley-Usmar; M T Wilson
On the identification and nomenclature of the polypeptide subunits of bovine cytochrome C oxidase.
Biochemical and biophysical research communications 1981;99(1):51-7.
1981: G D Jones; M T Wilson; Victor Darley-Usmar
A method for the preparation of low-pH dodecyl sulphate/polyacrylamide-gradient gels.
The Biochemical journal 1981;193(3):1013-5.
1980: M T Wilson; W Lalla-Maharajh; Victor Darley-Usmar; J Bonaventura; C Bonaventura; M Brunori
Structural and functional properties of cytochrome c oxidases isolated from sharks.
The Journal of biological chemistry 1980;255(7):2722-8.