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Ype Elgersma

Research Profile

Living Beings

Physiology

Chemicals & Drugs

Calcium-Calmodulin-Dependent Protein Kinase Type 2

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Su Melser; Emilie Obre; Muriel Priault; Hamid Rezavani; Rodrigue Rossignol; Etienne Hébert Chatelain; Ype Elgersma; Susan Goorden; Caroline Jose; Julie Lavie; Walid Mahfouf; Giovanni Bénard
Rheb regulates mitophagy induced by mitochondrial energetic status.
Eero Castrén; Ype Elgersma; Lamberto Maffei; Randi J Hagerman
Treatment of neurodevelopmental disorders in adulthood.
Maria T Acosta; Carrie E Bearden; Xavier F Castellanos; LAURA CUTTING; Ype Elgersma; Gerard Gioia; David H Gutmann; Kim Hunter-Schaedle; Yong-Seok Lee; Eric Legius; Maximillian Muenke; Kathryn North; Luis F Parada; Nancy Ratner; F Xavier Castellanos; Alcino J Silva
The Learning Disabilities Network (LeaDNet): using neurofibromatosis type 1 (NF1) as a paradigm for translational research.

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All Publications

2013: Su Melser; Emilie Obre; Muriel Priault; Hamid Rezavani; Rodrigue Rossignol; Etienne Hébert Chatelain; Ype Elgersma; Susan Goorden; Caroline Jose; Julie Lavie; Walid Mahfouf; Giovanni Bénard
Rheb regulates mitophagy induced by mitochondrial energetic status.
Cell metabolism 2013;17(5):719-30.
2012: Eero Castrén; Ype Elgersma; Lamberto Maffei; Randi J Hagerman
Treatment of neurodevelopmental disorders in adulthood.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2012;32(41):14074-9.
2012: Maria T Acosta; Carrie E Bearden; Xavier F Castellanos; LAURA CUTTING; Ype Elgersma; Gerard Gioia; David H Gutmann; Kim Hunter-Schaedle; Yong-Seok Lee; Eric Legius; Maximillian Muenke; Kathryn North; Luis F Parada; Nancy Ratner; F Xavier Castellanos; Alcino J Silva
The Learning Disabilities Network (LeaDNet): using neurofibromatosis type 1 (NF1) as a paradigm for translational research.
American journal of medical genetics. Part A 2012;158A(9):2225-32.
2012: Thomas Steinkellner; Sonja Sucic; Marie-Therese Winkler; Jae-Won Yang; Wei-Qiang Chen; Ype Elgersma; Michael Freissmuth; Gert Lubec; Therese R Montgomery; Harald H Sitte; Oliver Kudlacek
Ca(2+)/calmodulin-dependent protein kinase IIα (αCaMKII) controls the activity of the dopamine transporter: implications for Angelman syndrome.
The Journal of biological chemistry 2012;287(35):29627-35.
2012: Nico J M van Beveren; Peter van der Spek; Gabriëlle H S Buitendijk; Erik Boot; Gabriella Buitendijk; Ype Elgersma; Lianne C Krab; SM Swagemakers; Therese van Amelsvoort
Functional gene-expression analysis shows involvement of schizophrenia-relevant pathways in patients with 22q11 deletion syndrome.
PloS one 2012;7(3):e33473.
2012: Nico J M van Beveren; Peter van der Spek; Gabrielle H S Buitendijk; Lieuwe de Haan; Lianne C Krab; Christian Röder; SM Swagemakers; Ype Elgersma
Marked reduction of AKT1 expression and deregulation of AKT1-associated pathways in peripheral blood mononuclear cells of schizophrenia patients.
PloS one 2012;7(2):e32618.
2012: Jeiwon Cho; Ype Elgersma; Rushi Bhatt; Alcino J Silva
α-Calcium calmodulin kinase II modulates the temporal structure of hippocampal bursting patterns.
PloS one 2012;7(2):e31649.
2011: Nils Z Borgesius; Monique C de Waard; Jan H J Hoeijmakers; Dick Jaarsma; David W Melton; Azar Omrani; Gijsbertus T J van der Horst; Ingrid van der Pluijm; Gerben C M Zondag; Ype Elgersma
Accelerated age-related cognitive decline and neurodegeneration, caused by deficient DNA repair.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2011;31(35):12543-53.
2011: Efstathios B Papachristos; Edwin H Jacobs; Ype Elgersma
Interval timing is intact in arrhythmic Cry1/Cry2-deficient mice.
Journal of biological rhythms 2011;26(4):305-13.
2011: Susanna M I Goorden; Ype Elgersma
Rheb: enrichment beyond the brain.
Cell cycle (Georgetown, Tex.) 2011;10(15):2412-3.
2011: Nils Z Borgesius; Gabrielle H S Buitendijk; Casper C Hoogenraad; Dick Jaarsma; Nanda Keijzer; Geeske M van Woerden; Ype Elgersma
βCaMKII plays a nonenzymatic role in hippocampal synaptic plasticity and learning by targeting αCaMKII to synapses.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2011;31(28):10141-8.
2011: T van der Vaart; G M van Woerden; Ype Elgersma; Chris I De Zeeuw; M Schonewille
Motor deficits in neurofibromatosis type 1 mice: the role of the cerebellum.
Genes, brain, and behavior 2011;10(4):404-9.
2011: Susanna M I Goorden; Marianne Hoogeveen-Westerveld; Caroline Cheng; Geeske M van Woerden; Melika Mozaffari; Laura Post; Henricus J Duckers; Mark Nellist; Ype Elgersma
Rheb is essential for murine development.
Molecular and cellular biology 2011;31(8):1672-8.
2011: Lianne C Krab; Arja de Goede-Bolder; Femke K Aarsen; Henriëtte A Moll; Chris I De Zeeuw; Ype Elgersma; Josef N Van der Geest
Motor learning in children with neurofibromatosis type I.
Cerebellum (London, England) 2011;10(1):14-21.
2010: Amor Belmeguenai; Eric Hosy; Fredrik Bengtsson; Christine M Pedroarena; Claire Piochon; Eva Teuling; Qionger He; Gen Ohtsuki; Marcel T G De Jeu; Ype Elgersma; Chris I De Zeeuw; Henrik Jörntell; Christian Hansel
Intrinsic plasticity complements long-term potentiation in parallel fiber input gain control in cerebellar Purkinje cells.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2010;30(41):13630-43.
2010: Monique C de Waard; Ingrid van der Pluijm; Nils Zuiderveen Borgesius; Laura H Comley; Elize D Haasdijk; Yvonne Rijksen; Yanto Ridwan; Gerben Zondag; Jan H J Hoeijmakers; Ype Elgersma; Thomas H Gillingwater; Dick Jaarsma
Age-related motor neuron degeneration in DNA repair-deficient Ercc1 mice.
Acta neuropathologica 2010;120(4):461-75.
2010: Martijn Schonewille; Amor Belmeguenai; S K E Koekkoek; Simone H Houtman; H J Boele; B J van Beugen; Z Gao; A Badura; G Ohtsuki; W E Amerika; E Hosy; Freek E Hoebeek; Ype Elgersma; Christian Hansel; Chris I De Zeeuw
Purkinje cell-specific knockout of the protein phosphatase PP2B impairs potentiation and cerebellar motor learning.
Neuron 2010;67(4):618-28.
2009: Geeske M van Woerden; Freek E Hoebeek; Zhenyu Gao; Raghavendra Y Nagaraja; Casper C Hoogenraad; Steven A Kushner; Christian Hansel; Chris I De Zeeuw; Ype Elgersma
betaCaMKII controls the direction of plasticity at parallel fiber-Purkinje cell synapses.
Nature neuroscience 2009;12(7):823-5.
2009: Lianne C Krab; Rianne Oostenbrink; Arja de Goede-Bolder; Femke K Aarsen; Ype Elgersma; Henriëtte A Moll
Health-related quality of life in children with neurofibromatosis type 1: contribution of demographic factors, disease-related factors, and behavior.
The Journal of pediatrics 2009;154(3):420-5, 425.e1.
2008: Ellen Denayer; Tariq Ahmed; Hilde Brems; Geeske Van Woerden; Nils Zuiderveen Borgesius; Zsuzsanna Callaerts-Vegh; Akihiko Yoshimura; Dieter Hartmann; Ype Elgersma; Rudi D'Hooge; Eric Legius; Detlef Balschun
Spred1 is required for synaptic plasticity and hippocampus-dependent learning.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2008;28(53):14443-9.
2008: Yijun Cui; Rui M Costa; Geoffrey G Murphy; Ype Elgersma; Yuan Zhu; David H Gutmann; Luis F Parada; Istvan Mody; Alcino J Silva
Neurofibromin regulation of ERK signaling modulates GABA release and learning.
Cell 2008;135(3):549-60.
2008: Lianne C Krab; Susanna M I Goorden; Ype Elgersma
Oncogenes on my mind: ERK and MTOR signaling in cognitive diseases.
Trends in genetics : TIG 2008;24(10):498-510.
2008: Lianne C Krab; Femke K Aarsen; Arja de Goede-Bolder; Coriene E Catsman-Berrevoets; W F M Arts; Henriëtte A Moll; Ype Elgersma
Impact of neurofibromatosis type 1 on school performance.
Journal of child neurology 2008;23(9):1002-10.
2008: Lianne C Krab; Arja de Goede-Bolder; Femke K Aarsen; Saskia M F Pluijm; Marlies J Bouman; Jos N van der Geest; Maarten H Lequin; Coriene E Catsman; W F M Arts; Steven A Kushner; Alcino J Silva; Chris I De Zeeuw; Henriëtte A Moll; Ype Elgersma
Effect of simvastatin on cognitive functioning in children with neurofibromatosis type 1: a randomized controlled trial.
JAMA : the journal of the American Medical Association 2008;300(3):287-94.
2008: Johanna E Olijslagers; Ron de Kloet; Ype Elgersma; G M van Woerden; Marian Joëls; Henk Karst
Rapid changes in hippocampal CA1 pyramidal cell function via pre- as well as postsynaptic membrane mineralocorticoid receptors.
The European journal of neuroscience 2008;27(10):2542-50.
2008: S J P M van Engelen; L C Krab; Henriëtte A Moll; A de Goede-Bolder; S M F Pluijm; Coriene E Catsman-Berrevoets; Ype Elgersma; Maarten H Lequin
Quantitative differentiation between healthy and disordered brain matter in patients with neurofibromatosis type I using diffusion tensor imaging.
AJNR. American journal of neuroradiology 2008;29(4):816-22.
2008: C S Park; Ype Elgersma; S G N Grant; John H Morrison
alpha-Isoform of calcium-calmodulin-dependent protein kinase II and postsynaptic density protein 95 differentially regulate synaptic expression of NR2A- and NR2B-containing N-methyl-d-aspartate receptors in hippocampus.
Neuroscience 2008;151(1):43-55.
2007: Susanna M I Goorden; Geeske M van Woerden; Louise van der Weerd; Jeremy P Cheadle; Ype Elgersma
Cognitive deficits in Tsc1+/- mice in the absence of cerebral lesions and seizures.
Annals of neurology 2007;62(6):648-55.
2007: Mohammad Reza Hojjati; Geeske M van Woerden; William Tyler; peter giese; Alcino J Silva; Lucas Pozzo-Miller; Ype Elgersma
Kinase activity is not required for alphaCaMKII-dependent presynaptic plasticity at CA3-CA1 synapses.
Nature neuroscience 2007;10(9):1125-7.
2007: Ype Elgersma
Genetic engineering cures mice of neurological deficits: prospects for treating Angelman syndrome.
Pharmacogenomics 2007;8(6):539-41.
2007: Geeske M van Woerden; Karen D Harris; Mohammad Reza Hojjati; Richard M Gustin; Shenfeng Qiu; Rogerio de Avila Freire; Yong-Hui Jiang; Ype Elgersma; Edwin J Weeber
Rescue of neurological deficits in a mouse model for Angelman syndrome by reduction of alphaCaMKII inhibitory phosphorylation.
Nature neuroscience 2007;10(3):280-2.
2006: Christian Hansel; Marcel T G De Jeu; Amor Belmeguenai; Simone H Houtman; Gabriëlle H S Buitendijk; Dmitri Andreev; Chris I De Zeeuw; Ype Elgersma
alphaCaMKII Is essential for cerebellar LTD and motor learning.
Neuron 2006;51(6):835-43.
2005: Steven A Kushner; Ype Elgersma; Geoffrey G Murphy; Dick Jaarsma; Geeske M van Woerden; Mohammad Reza Hojjati; Yijun Cui; Janelle C Leboutillier; Diano F Marrone; Esther S Choi; Chris I De Zeeuw; Ted L Petit; Lucas Pozzo-Miller; Alcino J Silva
Modulation of presynaptic plasticity and learning by the H-ras/extracellular signal-regulated kinase/synapsin I signaling pathway.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2005;25(42):9721-34.
2005: Eric burguière; Angelo Arleo; Mohammad Reza Hojjati; Ype Elgersma; Chris I De Zeeuw; Alain Berthoz; Laure Rondi-Reig
Spatial navigation impairment in mice lacking cerebellar LTD: a motor adaptation deficit?
Nature neuroscience 2005;8(10):1292-4.
2005: Lian Zhang; Timo Kirschstein; Britta Sommersberg; Malte Merkens; Denise Manahan-Vaughan; Ype Elgersma; Heinz Beck
Hippocampal synaptic metaplasticity requires inhibitory autophosphorylation of Ca2+/calmodulin-dependent kinase II.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2005;25(33):7697-707.
2004: Ype Elgersma; J David Sweatt; peter giese
Mouse genetic approaches to investigating calcium/calmodulin-dependent protein kinase II function in plasticity and cognition.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2004;24(39):8410-5.
2003: S K E Koekkoek; H C Hulscher; Bjorn Dortland; R A Hensbroek; Ype Elgersma; Tom J H Ruigrok; Chris I De Zeeuw
Cerebellar LTD and learning-dependent timing of conditioned eyelid responses.
Science (New York, N.Y.) 2003;301(5640):1736-9.
2003: Edwin J Weeber; Yong-Hui Jiang; Ype Elgersma; Andrew W Varga; Yarimar Carrasquillo; Sarah E Brown; Jill M Christian; Banefsheh Mirnikjoo; Alcino Silva; Arthur L Beaudet; J David Sweatt
Derangements of hippocampal calcium/calmodulin-dependent protein kinase II in a mouse model for Angelman mental retardation syndrome.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2003;23(7):2634-44.
2002: Werner M Kistler; Marcel T G De Jeu; Ype Elgersma; Ruben S Van Der Giessen; R Hensbroek; Chongde Luo; S K E Koekkoek; Casper C Hoogenraad; F P T Hamers; M Gueldenagel; G Sohl; Klaus Willecke; Chris I De Zeeuw
Analysis of Cx36 knockout does not support tenet that olivary gap junctions are required for complex spike synchronization and normal motor performance.
Annals of the New York Academy of Sciences 2002;978():391-404.
2002: Ype Elgersma; Nikolai B Fedorov; Sami Ikonen; Esther S Choi; Minetta Elgersma; Ofelia M Carvalho; peter giese; Alcino J Silva
Inhibitory autophosphorylation of CaMKII controls PSD association, plasticity, and learning.
Neuron 2002;36(3):493-505.
2000: Alcino J Silva; Ype Elgersma; Rui M Costa
Molecular and cellular mechanisms of cognitive function: implications for psychiatric disorders.
Biological psychiatry 2000;47(3):200-9.
2000: Ben Distel; Ineke Braakman; Ype Elgersma; Henk F Tabak
Transactions at the peroxisomal membrane.
Sub-cellular biochemistry 2000;34():303-22.
1999: Ype Elgersma; Alcino J Silva
Molecular mechanisms of synaptic plasticity and memory.
Current opinion in neurobiology 1999;9(2):209-13.
1998: Alcino J Silva; Ype Elgersma; E Friedman; J Stern; Jeffrey H Kogan
A mouse model for learning and memory defects associated with neurofibromatosis type I.
Pathologie-biologie 1998;46(9):697-8.
1998: Ype Elgersma; M Elgersma-Hooisma; TJ Wenzel; J M McCaffery; M G Farquhar; Suresh Subramani
A mobile PTS2 receptor for peroxisomal protein import in Pichia pastoris.
The Journal of cell biology 1998;140(4):807-20.
1998: KN Faber; Ype Elgersma; J A Heyman; Antonius Koller; Georg H Lüers; W M Nuttley; Stanley R Terlecky; TJ Wenzel; Suresh Subramani
Use of Pichia pastoris as a model eukaryotic system. Peroxisome biogenesis.
Methods in molecular biology (Clifton, N.J.) 1998;103():121-47.
1997: Ype Elgersma; L Kwast; M van den Berg; William B Snyder; Ben Distel; Suresh Subramani; Henk F Tabak
Overexpression of Pex15p, a phosphorylated peroxisomal integral membrane protein required for peroxisome assembly in S.cerevisiae, causes proliferation of the endoplasmic reticulum membrane.
The EMBO journal 1997;16(24):7326-41.
1997: N Verleur; Ype Elgersma; Carlo W T van Roermund; Henk F Tabak; R J Wanders
Cytosolic aspartate aminotransferase encoded by the AAT2 gene is targeted to the peroxisomes in oleate-grown Saccharomyces cerevisiae.
European journal of biochemistry / FEBS 1997;247(3):972-80.
1996: Ype Elgersma; Henk F Tabak
Proteins involved in peroxisome biogenesis and functioning.
Biochimica et biophysica acta 1996;1286(3):269-83.
1996: Ype Elgersma; A Vos; Marlene van den Berg; Carlo W T van Roermund; P van der Sluijs; Ben Distel; Henk F Tabak
Analysis of the carboxyl-terminal peroxisomal targeting signal 1 in a homologous context in Saccharomyces cerevisiae.
The Journal of biological chemistry 1996;271(42):26375-82.
1996: Ype Elgersma; L Kwast; A Klein; T Voorn-Brouwer; Marlene van den Berg; B Metzig; T America; Henk F Tabak; Ben Distel
The SH3 domain of the Saccharomyces cerevisiae peroxisomal membrane protein Pex13p functions as a docking site for Pex5p, a mobile receptor for the import PTS1-containing proteins.
The Journal of cell biology 1996;135(1):97-109.
1995: Carlo W T van Roermund; Ype Elgersma; N Singh; R J Wanders; Henk F Tabak
The membrane of peroxisomes in Saccharomyces cerevisiae is impermeable to NAD(H) and acetyl-CoA under in vivo conditions.
The EMBO journal 1995;14(14):3480-6.
1995: Ype Elgersma; Carlo W T van Roermund; R J Wanders; Henk F Tabak
Peroxisomal and mitochondrial carnitine acetyltransferases of Saccharomyces cerevisiae are encoded by a single gene.
The EMBO journal 1995;14(14):3472-9.
1995: Henk F Tabak; Ype Elgersma; Ewald H Hettema; M M Franse; T Voorn-Brouwer; Ben Distel
Transport of proteins and metabolites across the impermeable membrane of peroxisomes.
Cold Spring Harbor symposia on quantitative biology 1995;60():649-55.
1993: I Van der Leij; M M Franse; Ype Elgersma; Ben Distel; Henk F Tabak
PAS10 is a tetratricopeptide-repeat protein that is essential for the import of most matrix proteins into peroxisomes of Saccharomyces cerevisiae.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(24):11782-6.
1993: Ype Elgersma; Marlene van den Berg; Henk F Tabak; Ben Distel
An efficient positive selection procedure for the isolation of peroxisomal import and peroxisome assembly mutants of Saccharomyces cerevisiae.
Genetics 1993;135(3):731-40.
1991: C Vink; D C van Gent; Ype Elgersma; Ronald H Plasterk
Human immunodeficiency virus integrase protein requires a subterminal position of its viral DNA recognition sequence for efficient cleavage.
Journal of virology 1991;65(9):4636-44.
1991: D C van Gent; Ype Elgersma; M W Bolk; C Vink; Ronald H Plasterk
DNA binding properties of the integrase proteins of human immunodeficiency viruses types 1 and 2.
Nucleic acids research 1991;19(14):3821-7.
1990: C Vink; Maarten Groenink; Ype Elgersma; R A Fouchier; M Tersmette; Ronald H Plasterk
Analysis of the junctions between human immunodeficiency virus type 1 proviral DNA and human DNA.
Journal of virology 1990;64(11):5626-7.