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Roelof Ottenhoff

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Wouter W Kallemeijn; Kah-Yee Li; André R A Marques; Roelof Ottenhoff; Johannes M F G Aerts; Jan Aten; Rolf G Boot; Jeroen D C Codée; Bogdan I Florea; Jianbing Jiang; Saskia Scheij; Hans van den Elst; Gijsbert A van der Marel; Cindy P A A van Roomen; Tineke M Voorn-Brouwer; Marthe T C Walvoort; Lianne I Willems; Martin D Witte; Herman S Overkleeft
Novel activity-based probes for broad-spectrum profiling of retaining β-exoglucosidases in situ and in vivo.
Carlos Vrins; Ying Zhao; Johannes M Aerts; Dirk R de Waart; Louis M Havekes; J Kar Kruyt; Roelof Ottenhoff; Patrick C N Rensen; Theo J C van Berkel; Karin van den Oever; Miranda van Eck; Albert K Groen
Trans-intestinal cholesterol efflux is not mediated through high density lipoprotein.
Elisa Lombardo; Roelof Ottenhoff; Herman S Overkleeft; Martin van Eijk; Gijs H van Puijvelde; Cindy P A A van Roomen; Arthur J Verhoeven; Johannes M F G Aerts; Jan Aten; Albert K Groen; Johan Kuiper; Florence Bietrix
Correction of liver steatosis by a hydrophobic iminosugar modulating glycosphingolipids metabolism.

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2012: Wouter W Kallemeijn; Kah-Yee Li; André R A Marques; Roelof Ottenhoff; Johannes M F G Aerts; Jan Aten; Rolf G Boot; Jeroen D C Codée; Bogdan I Florea; Jianbing Jiang; Saskia Scheij; Hans van den Elst; Gijsbert A van der Marel; Cindy P A A van Roomen; Tineke M Voorn-Brouwer; Marthe T C Walvoort; Lianne I Willems; Martin D Witte; Herman S Overkleeft
Novel activity-based probes for broad-spectrum profiling of retaining β-exoglucosidases in situ and in vivo.
Angewandte Chemie (International ed. in English) 2012;51(50):12529-33.
2012: Carlos Vrins; Ying Zhao; Johannes M Aerts; Dirk R de Waart; Louis M Havekes; J Kar Kruyt; Roelof Ottenhoff; Patrick C N Rensen; Theo J C van Berkel; Karin van den Oever; Miranda van Eck; Albert K Groen
Trans-intestinal cholesterol efflux is not mediated through high density lipoprotein.
Journal of lipid research 2012;53(10):2017-23.
2012: Elisa Lombardo; Roelof Ottenhoff; Herman S Overkleeft; Martin van Eijk; Gijs H van Puijvelde; Cindy P A A van Roomen; Arthur J Verhoeven; Johannes M F G Aerts; Jan Aten; Albert K Groen; Johan Kuiper; Florence Bietrix
Correction of liver steatosis by a hydrophobic iminosugar modulating glycosphingolipids metabolism.
PloS one 2012;7(10):e38520.
2012: Mirjam Langeveld; Judith H Houben-Weerts; Nora Bijl; Sjoerd van den Berg; Silvia Bijland; Roelof Ottenhoff; Johannes A Romijn; Cindy P van Roomen; Albert K Groen; Sander M Houten; Ko Willems van Dijk; Johannes M Aerts; Peter J Voshol
Treatment of genetically obese mice with the iminosugar N-(5-adamantane-1-yl-methoxy-pentyl)-deoxynojirimycin reduces body weight by decreasing food intake and increasing fat oxidation.
Metabolism: clinical and experimental 2012;61(1):99-107.
2011: Ying Zhao; Carlos L J Vrins; Laura Calpe-Berdiel; M John Chapman; Albert K Groen; Reeni B Hildebrand; Menno Hoekstra; Thierry Huby; Wendy Jessup; J Kar Kruijt; Wilfried Le Goff; Roelof Ottenhoff; Marieke Pennings; Theo Van berkel; Ronald van der Sluis; Miranda van Eck
Hypocholesterolemia, foam cell accumulation, but no atherosclerosis in mice lacking ABC-transporter A1 and scavenger receptor BI.
Atherosclerosis 2011;218(2):314-22.
2011: Johannes M Aerts; Jan Aten; Florence M Bietrix; Nora Bijl; Rolf G Boot; Nick Dekker; Albert K Groen; Johanna E M Groener; Mirjam Langeveld; Elisa Lombardo; Roelof Ottenhoff; Mireille Serlie; Marco van Eijk; Cindy van Roomen; Tom Wennekes; Herman S Overkleeft
Glycosphingolipids and insulin resistance.
Advances in experimental medicine and biology 2011;721():99-119.
2010: Martin D Witte; Wouter W Kallemeijn; Jan Aten; Kah-Yee Li; Anneke Strijland; Wilma E Donker-Koopman; Adrianus M C H van den Nieuwendijk; Boris Bleijlevens; Gertjan Kramer; Bogdan I Florea; Berend Hooibrink; Carla E M Hollak; Roelof Ottenhoff; Rolf G Boot; Gijsbert A van der Marel; Herman S Overkleeft; Johannes M F G Aerts
Ultrasensitive in situ visualization of active glucocerebrosidase molecules.
Nature chemical biology 2010;6(12):907-13.
2010: Milka Sokolović; Aleksandar Sokolović; Cindy P A A van Roomen; Anna Gruber; Roelof Ottenhoff; Saskia Scheij; Theodorus B M Hakvoort; Wouter H Lamers; Albert K Groen
Unexpected effects of fasting on murine lipid homeostasis--transcriptomic and lipid profiling.
Journal of hepatology 2010;52(5):737-44.
2010: Florence Bietrix; Elisa Lombardo; Cindy P A A van Roomen; Roelof Ottenhoff; Mariska Vos; Patrick C N Rensen; Arthur J Verhoeven; Johannes M Aerts; Albert K Groen
Inhibition of glycosphingolipid synthesis induces a profound reduction of plasma cholesterol and inhibits atherosclerosis development in APOE*3 Leiden and low-density lipoprotein receptor-/- mice.
Arteriosclerosis, thrombosis, and vascular biology 2010;30(5):931-7.
2010: Tom Wennekes; Alfred J Meijer; Albert K Groen; Rolf G Boot; Johanna E M Groener; Martin van Eijk; Roelof Ottenhoff; Nora Bijl; Karen Ghauharali; Hang Song; Tom J O'Shea; Hanlan Liu; Nelson Yew; Diane Copeland; Richard J B H N van den Berg; Gijsbert A van der Marel; Herman S Overkleeft; Johannes M Aerts
Dual-action lipophilic iminosugar improves glycemic control in obese rodents by reduction of visceral glycosphingolipids and buffering of carbohydrate assimilation.
Journal of medicinal chemistry 2010;53(2):689-98.
2009: Nora Bijl; Milka Sokolović; Carlos Vrins; Mirjam Langeveld; Perry Moerland; Roelof Ottenhoff; Cindy P A A van Roomen; Nike Claessen; Rolf G Boot; Jan Aten; Albert K Groen; Johannes M F G Aerts; Martin van Eijk
Modulation of glycosphingolipid metabolism significantly improves hepatic insulin sensitivity and reverses hepatic steatosis in mice.
Hepatology (Baltimore, Md.) 2009;50(5):1431-41.
2009: Nora Bijl; Cindy P A A van Roomen; Vassilis Triantis; Milka Sokolović; Roelof Ottenhoff; Saskia Scheij; Martin van Eijk; Rolf G Boot; Johannes M Aerts; Albert K Groen
Reduction of glycosphingolipid biosynthesis stimulates biliary lipid secretion in mice.
Hepatology (Baltimore, Md.) 2009;49(2):637-45.
2009: Martin van Eijk; Jan Aten; Nora Bijl; Roelof Ottenhoff; Cindy P A A van Roomen; Peter F Dubbelhuis; Ingar Seeman; Karen Ghauharali-van der Vlugt; Herman S Overkleeft; Cynthia Arbeeny; Albert K Groen; Johannes M F G Aerts
Reducing glycosphingolipid content in adipose tissue of obese mice restores insulin sensitivity, adipogenesis and reduces inflammation.
PloS one 2009;4(3):e4723.
2008: johannes aerts; Johanna E M Groener; Sijmen Kuiper; Wilma E Donker-Koopman; Anneke Strijland; Roelof Ottenhoff; Cindy van Roomen; Mina Mirzaian; Frits A Wijburg; Gabor E Linthorst; Anouk C Vedder; Saskia M Rombach; J Cox-Brinkman; Pentti Somerharju; Rolf G Boot; Carla E M Hollak; Roscoe O Brady; B J H M Poorthuis
Elevated globotriaosylsphingosine is a hallmark of Fabry disease.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(8):2812-7.
2008: Thijs W H Pols; Roelof Ottenhoff; Mariska Vos; Johannes Levels; Paul H A Quax; Joost C M Meijers; Hans Pannekoek; Albert K Groen; Carlie J M de Vries
Nur77 modulates hepatic lipid metabolism through suppression of SREBP1c activity.
Biochemical and biophysical research communications 2008;366(4):910-6.
2007: johannes aerts; Roelof Ottenhoff; Andrew S Powlson; Aldo Grefhorst; Martin van Eijk; Peter F Dubbelhuis; Jan Aten; Folkert Kuipers; Mireille J Serlie; Tom Wennekes; Jaswinder Sethi; Stephen O'Rahilly; Herman S Overkleeft
Pharmacological inhibition of glucosylceramide synthase enhances insulin sensitivity.
Diabetes 2007;56(5):1341-9.
2004: Ronald P J Oude Elferink; Roelof Ottenhoff; Gert Fricker; David J Seward; Nazzareno Ballatori; James Boyer
Lack of biliary lipid excretion in the little skate, Raja erinacea, indicates the absence of functional Mdr2, Abcg5, and Abcg8 transporters.
American journal of physiology. Gastrointestinal and liver physiology 2004;286(5):G762-8.
2004: Ludmila Pawlikowska; Annemiek Groen; Elaine F Eppens; Cindy Kunne; Roelof Ottenhoff; Norbert Looije; Alex S Knisely; Nigel P Killeen; Laura N Bull; Ronald P J Oude Elferink; Nelson B Freimer
A mouse genetic model for familial cholestasis caused by ATP8B1 mutations reveals perturbed bile salt homeostasis but no impairment in bile secretion.
Human molecular genetics 2004;13(8):881-92.
2003: Juan F Medina; Sergio Recalde; Jesús Prieto; Jon Lecanda; Elena Saez; Colin D Funk; Paola Vecino; Marian A van Roon; Roelof Ottenhoff; Piter J Bosma; Conny T Bakker; Ronald P J Oude Elferink
Anion exchanger 2 is essential for spermiogenesis in mice.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(26):15847-52.
2003: Astrid Kosters; Raoul J J M Frijters; Frank G Schaap; Edwin Vink; Torsten Plösch; Roelof Ottenhoff; Milan Jirsa; Iris M De Cuyper; Folkert Kuipers; Albert K Groen
Relation between hepatic expression of ATP-binding cassette transporters G5 and G8 and biliary cholesterol secretion in mice.
Journal of hepatology 2003;38(6):710-6.
2002: Hendrik N van der Vliet; Frank G Schaap; Johannes Levels; Roelof Ottenhoff; Norbert Looije; John G Wesseling; Albert K Groen; Robert Chamuleau
Adenoviral overexpression of apolipoprotein A-V reduces serum levels of triglycerides and cholesterol in mice.
Biochemical and biophysical research communications 2002;295(5):1156-9.
2001: Christoph G Dietrich; Roelof Ottenhoff; Dirk R de Waart; Ronald P J Oude Elferink
Role of MRP2 and GSH in intrahepatic cycling of toxins.
Toxicology 2001;167(1):73-81.
2001: Albert K Groen; Vincent Bloks; R H Bandsma; Roelof Ottenhoff; Giovanna Chimini; Folkert Kuipers
Hepatobiliary cholesterol transport is not impaired in Abca1-null mice lacking HDL.
The Journal of clinical investigation 2001;108(6):843-50.
2001: Catherina P Nibbering; Albert K Groen; Roelof Ottenhoff; Jos F Brouwers; Gerard P vanBerge-Henegouwen; Karel J van Erpecum
Regulation of biliary cholesterol secretion is independent of hepatocyte canalicular membrane lipid composition: a study in the diosgenin-fed rat model.
Journal of hepatology 2001;35(2):164-9.
2001: Christoph G Dietrich; Dirk R de Waart; Roelof Ottenhoff; A H Bootsma; A H van Gennip; Ronald P J Oude Elferink
Mrp2-deficiency in the rat impairs biliary and intestinal excretion and influences metabolism and disposition of the food-derived carcinogen 2-amino-1-methyl-6-phenylimidazo.
Carcinogenesis 2001;22(5):805-11.
2001: Christoph G Dietrich; Dirk R de Waart; Roelof Ottenhoff; I G Schoots; Ronald P J Oude Elferink
Increased bioavailability of the food-derived carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine in MRP2-deficient rats.
Molecular pharmacology 2001;59(5):974-80.
2001: Christoph G Dietrich; Roelof Ottenhoff; Dirk R de Waart; Ronald P J Oude Elferink
Lack of UGT1 isoforms in Gunn rats changes metabolic ratio and facilitates excretion of the food-derived carcinogen 2-amino-1-methyl-6-phenylimidazo.
Toxicology and applied pharmacology 2001;170(2):137-43.
2000: J Marleen L de Vree; Roelof Ottenhoff; Piter J Bosma; AJ Smith; Jan Aten; Ronald P J Oude Elferink
Correction of liver disease by hepatocyte transplantation in a mouse model of progressive familial intrahepatic cholestasis.
Gastroenterology 2000;119(6):1720-30.
1999: Charles Frijters; coosje tuijn; Roelof Ottenhoff; B N Zegers; Albert K Groen; Ronald P J Oude Elferink
The role of different P-glycoproteins in hepatobiliary secretion of fluorescently labeled short-chain phospholipids.
Journal of lipid research 1999;40(11):1950-8.
1999: Ardy van Helvoort; Arjan de Brouwer; Roelof Ottenhoff; Jos F Brouwers; Jan Wijnholds; Jos H Beijnen; A Rijneveld; T van der Poll; Martin van der Valk; Donné M Majoor; W Voorhout; Karel W A Wirtz; Ronald P J Oude Elferink; Piet Borst
Mice without phosphatidylcholine transfer protein have no defects in the secretion of phosphatidylcholine into bile or into lung airspaces.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(20):11501-6.
1999: Coen C Paulusma; M A van Geer; Raymond Evers; M Heijn; Roelof Ottenhoff; Piet Borst; Ronald P J Oude Elferink
Canalicular multispecific organic anion transporter/multidrug resistance protein 2 mediates low-affinity transport of reduced glutathione.
The Biochemical journal 1999;338 ( Pt 2)():393-401.
1998: Ronald P J Oude Elferink; Roelof Ottenhoff; J van Marle; Charles Frijters; A J Smith; Albert K Groen
Class III P-glycoproteins mediate the formation of lipoprotein X in the mouse.
The Journal of clinical investigation 1998;102(9):1749-57.
1998: AJ Smith; J Marleen L de Vree; Roelof Ottenhoff; Ronald P J Oude Elferink; Alfred H Schinkel; Piet Borst
Hepatocyte-specific expression of the human MDR3 P-glycoprotein gene restores the biliary phosphatidylcholine excretion absent in Mdr2 (-/-) mice.
Hepatology (Baltimore, Md.) 1998;28(2):530-6.
1998: Peter J Voshol; Rick Havinga; Henk Wolters; Roelof Ottenhoff; Hans M G Princen; Ronald P J Oude Elferink; Albert K Groen; Folkert Kuipers
Reduced plasma cholesterol and increased fecal sterol loss in multidrug resistance gene 2 P-glycoprotein-deficient mice.
Gastroenterology 1998;114(5):1024-34.
1997: Charles Frijters; Roelof Ottenhoff; Michel J A Van Wijland; C M van Nieuwkerk; Albert K Groen; Ronald P J Oude Elferink
Regulation of mdr2 P-glycoprotein expression by bile salts.
The Biochemical journal 1997;321 ( Pt 2)():389-95.
1997: C M van Nieuwerk; Albert K Groen; Roelof Ottenhoff; Michel J A Van Wijland; M A van den Bergh Weerman; G N J Tytgat; G Johan A Offerhaus; Ronald P J Oude Elferink
The role of bile salt composition in liver pathology of mdr2 (-/-) mice: differences between males and females.
Journal of hepatology 1997;26(1):138-45.
1997: Jurgen Seppen; K Tada; Roelof Ottenhoff; K Sengupta; Namita Roy-Chowdhury; Jayanta Roy-Chowdhury; Piter J Bosma; Ronald P J Oude Elferink
Transplantation of Gunn rats with autologous fibroblasts expressing bilirubin UDP-glucuronosyltransferase: correction of genetic deficiency and tumor formation.
Human gene therapy 1997;8(1):27-36.
1996: C M Van Nieuwkerk; Ronald P J Oude Elferink; Albert K Groen; Roelof Ottenhoff; G N J Tytgat; K P Dingemans; M A Van Den Bergh Weerman; G Johan A Offerhaus
Effects of Ursodeoxycholate and cholate feeding on liver disease in FVB mice with a disrupted mdr2 P-glycoprotein gene.
Gastroenterology 1996;111(1):165-71.
1996: Ronald P J Oude Elferink; Roelof Ottenhoff; M van Wijland; Charles Frijters; C van Nieuwkerk; Albert K Groen
Uncoupling of biliary phospholipid and cholesterol secretion in mice with reduced expression of mdr2 P-glycoprotein.
Journal of lipid research 1996;37(5):1065-75.
1996: Charles Frijters; Roelof Ottenhoff; M J Van Wijland; C Van Nieuwkerk; Albert K Groen; Ronald P J Oude Elferink
Influence of bile salts on hepatic mdr2 P-glycoprotein expression.
Advances in enzyme regulation 1996;36():351-63.
1995: H Roelofsen; B Schoemaker; C Bakker; Roelof Ottenhoff; Peter L M Jansen; Ronald P J Oude Elferink
Impaired hepatocanalicular organic anion transport in endotoxemic rats.
The American journal of physiology 1995;269(3 Pt 1):G427-34.
1995: Ronald P J Oude Elferink; Roelof Ottenhoff; M van Wijland; J J Smit; Alfred H Schinkel; Albert K Groen
Regulation of biliary lipid secretion by mdr2 P-glycoprotein in the mouse.
The Journal of clinical investigation 1995;95(1):31-8.
1994: H Roelofsen; C N van der Veere; Roelof Ottenhoff; B Schoemaker; Peter L M Jansen; Ronald P J Oude Elferink
Decreased bilirubin transport in the perfused liver of endotoxemic rats.
Gastroenterology 1994;107(4):1075-84.
1993: J J Smit; Alfred H Schinkel; Ronald P J Oude Elferink; Albert K Groen; Els Wagenaar; Liesbeth Van Deemter; CA Mol; Roelof Ottenhoff; N M van der Lugt; M A van Roon
Homozygous disruption of the murine mdr2 P-glycoprotein gene leads to a complete absence of phospholipid from bile and to liver disease.
Cell 1993;75(3):451-62.
1993: Peter L M Jansen; J W van Klinken; M van Gelder; Roelof Ottenhoff; Ronald P J Oude Elferink
Preserved organic anion transport in mutant TR- rats with a hepatobiliary secretion defect.
The American journal of physiology 1993;265(3 Pt 1):G445-52.
1993: Ronald P J Oude Elferink; C T Bakker; H Roelofsen; E Middelkoop; Roelof Ottenhoff; M Heijn; Peter L M Jansen
Accumulation of organic anion in intracellular vesicles of cultured rat hepatocytes is mediated by the canalicular multispecific organic anion transporter.
Hepatology (Baltimore, Md.) 1993;17(3):434-44.
1991: H Roelofsen; Roelof Ottenhoff; Ronald P J Oude Elferink; Peter L M Jansen
Hepatocanalicular organic-anion transport is regulated by protein kinase C.
The Biochemical journal 1991;278 ( Pt 3)():637-41.
1991: Ronald P J Oude Elferink; Roelof Ottenhoff; A Radominska; Alan F Hofmann; Folkert Kuipers; Peter L M Jansen
Inhibition of glutathione-conjugate secretion from isolated hepatocytes by dipolar bile acids and other organic anions.
The Biochemical journal 1991;274 ( Pt 1)():281-6.
1990: Ronald P J Oude Elferink; Roelof Ottenhoff; W G Liefting; B Schoemaker; Albert K Groen; Peter L M Jansen
ATP-dependent efflux of GSSG and GS-conjugate from isolated rat hepatocytes.
The American journal of physiology 1990;258(5 Pt 1):G699-706.
1989: Ronald P J Oude Elferink; Roelof Ottenhoff; W Liefting; J de Haan; Peter L M Jansen
Hepatobiliary transport of glutathione and glutathione conjugate in rats with hereditary hyperbilirubinemia.
The Journal of clinical investigation 1989;84(2):476-83.
1989: Albert K Groen; Roelof Ottenhoff; Peter L M Jansen; J van Marle; G N J Tytgat
Effect of cholesterol nucleation-promoting activity on cholesterol solubilization in model bile.
Journal of lipid research 1989;30(1):51-8.