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Koichi tsuneyama

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Shiho Fujisaka; N Goda; M Ikutani; A Mahmood; Y Nagai; K Takatsu; A Takikawa; Koichi tsuneyama; Isao Usui; A Aminuddin; K Tobe
Adipose tissue hypoxia induces inflammatory M1 polarity of macrophages in an HIF-1α-dependent and HIF-1α-independent manner in obese mice.
Dong Han; So Motoyoshi; Seiichi Munesue; Hidehito Saito; Koichi tsuneyama; Takuo Watanabe; Myat Thu Thu Win; Yasuhiko Yamamoto; Hiroshi Yamamoto
Induction of receptor for advanced glycation end products by insufficient leptin action triggers pancreatic β-cell failure in type 2 diabetes.
K Nomoto; Koichi tsuneyama; S Hayashi; T Hori; S Ishizawa
Cytopathology of cervical mesonephric adenocarcinoma: a report of two cases.

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2013: Shiho Fujisaka; N Goda; M Ikutani; A Mahmood; Y Nagai; K Takatsu; A Takikawa; Koichi tsuneyama; Isao Usui; A Aminuddin; K Tobe
Adipose tissue hypoxia induces inflammatory M1 polarity of macrophages in an HIF-1α-dependent and HIF-1α-independent manner in obese mice.
Diabetologia 2013;56(6):1403-12.
2013: Dong Han; So Motoyoshi; Seiichi Munesue; Hidehito Saito; Koichi tsuneyama; Takuo Watanabe; Myat Thu Thu Win; Yasuhiko Yamamoto; Hiroshi Yamamoto
Induction of receptor for advanced glycation end products by insufficient leptin action triggers pancreatic β-cell failure in type 2 diabetes.
Genes to cells : devoted to molecular & cellular mechanisms 2013;18(4):302-14.
2013: K Nomoto; Koichi tsuneyama; S Hayashi; T Hori; S Ishizawa
Cytopathology of cervical mesonephric adenocarcinoma: a report of two cases.
Cytopathology : official journal of the British Society for Clinical Cytology 2013;24(2):129-31.
2013: Takeshi Nishida; Kazuhiro Nomoto; Yoshiyuki Sasaki; Tsutomu Shimada; Yutaka Shimada; Wataru Suzuki; Koichi tsuneyama; Masaki Aburada; Makoto Fujimoto; Shinichi Hayashi; Seiichi Iizuka; Shigeharu Miwa; Mitsunobu Nagata; Takahiko Nakajima; Yuko Nakanishi; Johji Imura
Spontaneous onset of nonalcoholic steatohepatitis and hepatocellular carcinoma in a mouse model of metabolic syndrome.
Laboratory investigation; a journal of technical methods and pathology 2013;93(2):230-41.
2013: Motoko Sasaki; Yasunori Sato; Koichi tsuneyama; Norihide Yoneda; Takashi Matsubara; Kazuhiro Nomoto; Yasuni Nakanuma
Overexpression of enhancer of zeste homolog 2 and MUC1 may be related to malignant behaviour in intraductal papillary neoplasm of the bile duct.
Histopathology 2013;62(3):446-57.
2013: Amy Dhirapong; Aftab A Ansari; Ross L Coppel; Xiaosong He; Stuart Knechtle; Patrick S C Leung; Fu-Tong Liu; Steven Nadler; Koichi tsuneyama; Guo-Xiang Yang; Weici Zhang; M Eric Gershwin
Therapeutic effect of cytotoxic T lymphocyte antigen 4/immunoglobulin on a murine model of primary biliary cirrhosis.
Hepatology (Baltimore, Md.) 2013;57(2):708-15.
2013: Masanobu Tsuda; Koichi tsuneyama; Guo-Xiang Yang; Weici Zhang; Yugo Ando; Aftab A Ansari; Ross L Coppel; Richard Flavell; Bin Gao; Xiao-Song He; Kazuhito Kawata; Patrick S C Leung; Zhe-Xiong Lian; Ogyi Park; William M Ridgway; M Eric Gershwin
Deletion of interleukin (IL)-12p35 induces liver fibrosis in dominant-negative TGFβ receptor type II mice.
Hepatology (Baltimore, Md.) 2013;57(2):806-16.
2013: Chikako Inada; Takeshi Miyata; Xoan Thi Le; Koichi tsuneyama; Hironori Fujiwara; Kinzo Matsumoto
Endogenous acetylcholine rescues NMDA-induced long-lasting hippocampal cell damage via stimulation of muscarinic M(1) receptors: elucidation using organic hippocampal slice cultures.
European journal of pharmacology 2013;699(1-3):150-9.
2013: Shiro Watanabe; Koichi tsuneyama
Eicosapentaenoic acid attenuates hepatic accumulation of cholesterol esters but aggravates liver injury and inflammation in mice fed a cholate-supplemented high-fat diet.
The Journal of toxicological sciences 2013;38(3):379-90.
2013: Tamehito Onoe; Koichi tsuneyama; Kazunori Yamada; Masakazu Yamagishi; Ryoko Hamano; Kenshi Hayashi; Satoshi Kagitani; Yasushi Kakuchi; Tadashi Konoshita; Masahiro Kuroda; Ichiro Mizushima; Hideki Nomura; Mitsuhiro Kawano
Situs inversus and cystic kidney disease: Two adult patients with this Heterogeneous syndrome.
The American journal of case reports 2013;14():20-5.
2013: Masahisa Arahata; Shinji Minami; Kazuhiro Nomoto; Kazuto Tajiri; Koichi tsuneyama; Yukihiro Shimizu
A novel type of selective immunoglobulin m deficiency in a patient with autoimmune liver cirrhosis with recurrent hepatocellular carcinoma: a case report and review of the literature.
International archives of allergy and immunology 2013;161(1):91-6.
2012: Takashi Matsubara; Osamu Matsui; Koichi Nakamura; Kazuhiro Nomoto; Motoko Sasaki; Yasunori Sato; Koichi tsuneyama; Toshifumi Gabata; Kenichi Harada; Yasuni Nakanuma
Immunohistochemical characteristics and malignant progression of hepatic cystic neoplasms in comparison with pancreatic counterparts.
Human pathology 2012;43(12):2177-86.
2012: Makoto Kurano; Teruhiko Matsushima; Koji Okamoto; Masumi Hara; Naoyuki Iso-o; Kazuhiko Koike; Koichi tsuneyama; Kazuhisa Tsukamoto
Modulation of lipid metabolism with the overexpression of NPC1L1 in mouse liver.
Journal of lipid research 2012;53(11):2275-85.
2012: Satonori Higuchi; Miki Nakajima; Shohei Takai; Koichi tsuneyama; Azusa Yano; Tatsuki Fukami; Tsuyoshi Yokoi
Metabolic activation and inflammation reactions involved in carbamazepine-induced liver injury.
Toxicological sciences : an official journal of the Society of Toxicology 2012;130(1):4-16.
2012: Yukitaka Yoshikawa; Shinya Endo; Tatsuki Fukami; Satonori Higuchi; Taishi Miyashita; Miki Nakajima; Yasuyuki Toyoda; Tohru Tsukui; Koichi tsuneyama; Tsuyoshi Yokoi
Mechanisms of the hepatoprotective effects of tamoxifen against drug-induced and chemical-induced acute liver injuries.
Toxicology and applied pharmacology 2012;264(1):42-50.
2012: Yugo Ando; Aftab A Ansari; Ross L Coppel; Xiaosong He; Kazuhito Kawata; Patrick S C Leung; Zhe-Xiong Lian; Takahiko Nakajima; Gary L Norman; Kazuichi Okazaki; William M Ridgway; Masanobu Tsuda; Koichi tsuneyama; Guo-Xiang Yang; Weici Zhang; M Eric Gershwin
The immunobiology of colitis and cholangitis in interleukin-23p19 and interleukin-17A deleted dominant negative form of transforming growth factor beta receptor type II mice.
Hepatology (Baltimore, Md.) 2012;56(4):1418-26.
2012: Satonori Higuchi; Masanori Kobayashi; Miki Nakajima; Koichi tsuneyama; Azusa Yano; Tatsuki Fukami; Tsuyoshi Yokoi
Involvement of Th2 cytokines in the mouse model of flutamide-induced acute liver injury.
Journal of applied toxicology : JAT 2012;32(10):815-22.
2012: Makoto Fujimoto; Takako Fujimoto; M Eric Gershwin; Carlo Selmi; Koichi tsuneyama; Yutaka Shimada
Spirulina improves non-alcoholic steatohepatitis, visceral fat macrophage aggregation, and serum leptin in a mouse model of metabolic syndrome.
Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver 2012;44(9):767-74.
2012: Takahiko Nakajima; Seiko Saito; Toshirou Sugiyama; Koichi tsuneyama; Junichi Fukushima; Kuniko Iihara; Hajime Horiuchi
[A case of gastrointestinal stromal tumor of the stomach mimicking a primary tumor of the omentum minus due to the extramural growth].
Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology 2012;109(8):1367-71.
2012: Shinji Shimoda; Koichi tsuneyama; Aftab A Ansari; M Eric Gershwin; Kenichi Harada; S Hisamoto; Hiromi Ishibashi; K Kikuchi; Patrick S C Leung; Mashio Nakamura; Yasuni Nakanuma; Hiroaki Niiro; Koichi Akashi
The role of natural killer (NK) and NK T cells in the loss of tolerance in murine primary biliary cirrhosis.
Clinical and experimental immunology 2012;168(3):279-84.
2012: Yasuharu Watanabe; Shizuo Akira; Shiho Fujisaka; Yoichiro Hirata; Yoshinori Ichihara; Sho Ishikawa; Hirofumi Izaki; Hiro-Omi Kanayama; Kensuke Miyake; Tomoya Nakamura; Yoshihiro Ogawa; Toshiyasu Sasaoka; Masataka Sata; Michio Shimabukuro; Takayoshi Suganami; Kiyoshi Takatsu; Kazuyuki Tobe; Koichi tsuneyama; Isao Usui; Tsutomu Wada; Yoshinori Nagai
The radioprotective 105/MD-1 complex contributes to diet-induced obesity and adipose tissue inflammation.
Diabetes 2012;61(5):1199-209.
2012: Qinglong Jin; Kentaro Kikuchi; Zhe-Xiong Lian; Ana Lleo; Hitoshi Moritoki; Yuki Moritoki; Aftab A Ansari; Ross L Coppel; M Eric Gershwin; Gideon M Hirschfield; Pietro Invernizzi; Koichi tsuneyama; Junqi Niu
Comparative analysis of portal cell infiltrates in antimitochondrial autoantibody-positive versus antimitochondrial autoantibody-negative primary biliary cirrhosis.
Hepatology (Baltimore, Md.) 2012;55(5):1495-506.
2012: Azusa Yano; Tatsuki Fukami; Satonori Higuchi; Miki Nakajima; Koichi tsuneyama; Tsuyoshi Yokoi
Involvement of immune-related factors in diclofenac-induced acute liver injury in mice.
Toxicology 2012;293(1-3):107-14.
2012: Yasuyuki Toyoda; Koichi tsuneyama; Azusa Yano; Shinya Endo; Tatsuki Fukami; Taishi Miyashita; Miki Nakajima; Tsuyoshi Yokoi
Mechanism of exacerbative effect of progesterone on drug-induced liver injury.
Toxicological sciences : an official journal of the Society of Toxicology 2012;126(1):16-27.
2012: Toru Takahashi; Koichi tsuneyama; Hiroyuki Usuda; Satoshi Yamada; Masahiko Yanagi; Xiaosong He; Yasunobu Matsuda; Tomofumi Miura; Tsutomu Miura; Junichiro Nakamura; Iwao Emura; M Eric Gershwin
Plasma cells and the chronic nonsuppurative destructive cholangitis of primary biliary cirrhosis.
Hepatology (Baltimore, Md.) 2012;55(3):846-55.
2012: Shiro Watanabe; Koichi tsuneyama
Cattle bile but not bear bile or pig bile induces lipid profile changes and fatty liver injury in mice: mediation by cholic acid.
The Journal of toxicological sciences 2012;37(1):105-21.
2012: Masashi Ikutani; Satoshi Takaki; Taku Kouro; Yuichi Hattori; Yoshinori Nagai; Masaru Ogasawara; Tsutomu Yanagibashi; Atsuko Itakura; Seiji Yamamoto; Koichi tsuneyama; Kiyoshi Takatsu
Identification of innate IL-5-producing cells and their role in lung eosinophil regulation and antitumor immunity.
Journal of immunology (Baltimore, Md. : 1950) 2012;188(2):703-13.
2012: Makoto Fujimoto; Takako Fujimoto; Johji Imura; Takeshi Nishida; Jiun-Liang Chen; Shao-Yuan Chen; Yen-Chen Chen; Koichi tsuneyama; Yutaka Shimada
Study of the effects of monacolin k and other constituents of red yeast rice on obesity, insulin-resistance, hyperlipidemia, and nonalcoholic steatohepatitis using a mouse model of metabolic syndrome.
Evidence-based complementary and alternative medicine : eCAM 2012;2012():892697.
2012: Takahiko Nakajima; Toshiro Sugiyama; Koichi tsuneyama; Tomonori Ushijima; Junichi Fukushima; Johji Imura; Atsushi Kihara; Kenichiro Murata; Hajime Horiuchi
A gastrointestinal stromal tumor of the stomach demonstrating a stepwise progression from low- to high-grade malignancy.
Case reports in gastrointestinal medicine 2012;2012():606832.
2012: Weici Zhang; Aftab A Ansari; Ross L Coppel; Xiaosong He; Patrick S C Leung; Zhe-Xiong Lian; William M Ridgway; Masanobu Tsuda; Koichi tsuneyama; Guo-Xiang Yang; M Eric Gershwin
Lymphoma-like T cell infiltration in liver is associated with increased copy number of dominant negative form of TGFβ receptor II.
PloS one 2012;7(11):e49413.
2012: Qi Zhao; Kinzo Matsumoto; Takeshi Miyata; Yimin Niu; Ken Tanaka; Koichi tsuneyama; Takako Yokozawa
Chotosan ameliorates cognitive and emotional deficits in an animal model of type 2 diabetes: possible involvement of cholinergic and VEGF/PDGF mechanisms in the brain.
BMC complementary and alternative medicine 2012;12():188.
2012: Taishi Miyashita; Miki Nakajima; Yasuyuki Toyoda; Koichi tsuneyama; Tatsuki Fukami; Tsuyoshi Yokoi
Hepatoprotective effect of tamoxifen on steatosis and non-alcoholic steatohepatitis in mouse models.
The Journal of toxicological sciences 2012;37(5):931-42.
2012: Patrick S C Leung; William M Ridgway; Koichi tsuneyama; Guo-Xiang Yang; Amy Dhirapong; M Eric Gershwin
Animal models of primary biliary cirrhosis: materials and methods.
Methods in molecular biology (Clifton, N.J.) 2012;900():291-316.
2012: Kazuto Tajiri; Yoshiharu Tokimitsu; Koichi tsuneyama; Yukihiro Shimizu; Toshiro Sugiyama
An elderly man with syncytial giant cell hepatitis successfully treated by immunosuppressants.
Internal medicine (Tokyo, Japan) 2012;51(16):2141-4.
2012: Kazuhiro Nomoto; Yoshiaki Tabuchi; Ichiro Takasaki; Makoto Fujimoto; Yuko Nakanishi; Takeshi Nishida; Koichi tsuneyama
Deficiency in galectin-3 promotes hepatic injury in CDAA diet-induced nonalcoholic fatty liver disease.
TheScientificWorldJournal 2012;2012():959824.
2012: Yu Yamaura; Tatsuki Fukami; Miki Nakajima; Shingo Takagi; Koichi tsuneyama; Tsuyoshi Yokoi
Plasma microRNA profiles in rat models of hepatocellular injury, cholestasis, and steatosis.
PloS one 2012;7(2):e30250.
2012: Sumiyo Sasaki; Yasuharu Watanabe; Yoshikatsu Hirai; Yoshinori Nagai; Masashi Ikutani; Koichi tsuneyama; Ai Kariyone; Tsutomu Yanagibashi; Kiyoshi Takatsu
Serum soluble MD-1 levels increase with disease progression in autoimmune prone MRL(lpr/lpr) mice.
Molecular immunology 2012;49(4):611-20.
2012: Koichi tsuneyama; Kentaro Kikuchi; Yuki Moritoki; Yasuni Nakanuma
Pathological features of new animal models for primary biliary cirrhosis.
International journal of hepatology 2012;2012():403954.
2011: Ya-Hui Huang; Patrick S C Leung; Wen-Yu Pan; Yao-Ming Shih; Yin Chen; Ho-Yuan Chou; Cheng-Chieh Fang; M Eric Gershwin; Koichi tsuneyama; Ping-Yi Wu; Mi-Hua Tao
A murine model of hepatitis B-associated hepatocellular carcinoma generated by adeno-associated virus-mediated gene delivery.
International journal of oncology 2011;39(6):1511-9.
2011: Y M Ambrosini; Aftab A Ansari; Ross Coppel; Patrick S C Leung; S Shu; M Tsuda; Koichi tsuneyama; Guo-Xiang Yang; W Zhang; M Eric Gershwin
The multi-hit hypothesis of primary biliary cirrhosis: polyinosinic-polycytidylic acid (poly I:C) and murine autoimmune cholangitis.
Clinical and experimental immunology 2011;166(1):110-20.
2011: Masanobu Tsuda; Koichi tsuneyama; Guo-Xiang Yang; Weici Zhang; Yoko M Ambrosini; Yugo Ando; Aftab A Ansari; Christopher L Bowlus; Ross L Coppel; Xiaosong He; Patrick S C Leung; Zhe-Xiong Lian; Guanghua Rong; Shinji Shimoda; Kosuke Sumida; M Eric Gershwin
Fine phenotypic and functional characterization of effector cluster of differentiation 8 positive T cells in human patients with primary biliary cirrhosis.
Hepatology (Baltimore, Md.) 2011;54(4):1293-302.
2011: N Hashimoto; H Kawanaka; N Kinjo; A Lleo; T Akahoshi; K Akashi; Aftab A Ansari; M Eric Gershwin; Shinji Shimoda; K Shirabe; A Taketomi; Koichi tsuneyama; H Uehara; Y Maehara
Modulation of CD4⁺ T cell responses following splenectomy in hepatitis C virus-related liver cirrhosis.
Clinical and experimental immunology 2011;165(2):243-50.
2011: Yoshiyuki Sasaki; Tsutomu Shimada; Seiichi Iizuka; Wataru Suzuki; Hiroko Makihara; Ryutaro Teraoka; Koichi tsuneyama; Ryoji Hokao; Masaki Aburada
Effects of bezafibrate in nonalcoholic steatohepatitis model mice with monosodium glutamate-induced metabolic syndrome.
European journal of pharmacology 2011;662(1-3):1-8.
2011: Yasuyuki Toyoda; Taishi Miyashita; Shinya Endo; Koichi tsuneyama; Tatsuki Fukami; Miki Nakajima; Tsuyoshi Yokoi
Estradiol and progesterone modulate halothane-induced liver injury in mice.
Toxicology letters 2011;204(1):17-24.
2011: Takao Hidaka; Akitoshi Nakashima; Toru Hasegawa; Kazuhiro Nomoto; Shin Ishizawa; Koichi tsuneyama; Yasuo Takano; Shigeru Saito
Ovarian squamous cell carcinoma which metastasized 8 years after cervical conization for early microinvasive cervical cancer: a case report.
Japanese journal of clinical oncology 2011;41(6):807-10.
2011: Shiho Fujisaka; Isao Usui; Yukiko Kanatani; Masashi Ikutani; Ichiro Takasaki; Koichi tsuneyama; Yoshiaki Tabuchi; Agussalim Bukhari; Yu Yamazaki; Hikari Suzuki; Satoko Senda; Aminuddin Aminuddin; Yoshinori Nagai; Kiyoshi Takatsu; Masashi Kobayashi; Kazuyuki Tobe
Telmisartan improves insulin resistance and modulates adipose tissue macrophage polarization in high-fat-fed mice.
Endocrinology 2011;152(5):1789-99.
2011: Shinji Shimoda; Kenichi Harada; Hiroaki Niiro; Ken Shirabe; Akinobu Taketomi; Yoshihiko Maehara; Koichi tsuneyama; Yasuni Nakanuma; Patrick S C Leung; Aftab A Ansari; M Eric Gershwin; Koichi Akashi
Interaction between Toll-like receptors and natural killer cells in the destruction of bile ducts in primary biliary cirrhosis.
Hepatology (Baltimore, Md.) 2011;53(4):1270-81.
2011: Si-Jie Wu; Yao-Hsu Yang; Koichi tsuneyama; Patrick S C Leung; Petr Illarionov; M Eric Gershwin; Ya-Hui Chuang
Innate immunity and primary biliary cirrhosis: activated invariant natural killer T cells exacerbate murine autoimmune cholangitis and fibrosis.
Hepatology (Baltimore, Md.) 2011;53(3):915-25.
2011: Yasuhiko Yamamoto; Ai Harashima; Hidehito Saito; Koichi tsuneyama; Seiichi Munesue; So Motoyoshi; Dong Han; Takuo Watanabe; Masahide Asano; Shin Takasawa; Hiroshi Okamoto; Satoshi Shimura; Tadahiro Karasawa; Hideto Yonekura; Hiroshi Yamamoto
Septic shock is associated with receptor for advanced glycation end products ligation of LPS.
Journal of immunology (Baltimore, Md. : 1950) 2011;186(5):3248-57.
2011: Satonori Higuchi; Masanori Kobayashi; Yukitaka Yoshikawa; Koichi tsuneyama; Tatsuki Fukami; Miki Nakajima; Tsuyoshi Yokoi
IL-4 mediates dicloxacillin-induced liver injury in mice.
Toxicology letters 2011;200(3):139-45.
2011: Amy Dhirapong; Ana Lleo; Guo-Xiang Yang; Koichi tsuneyama; Robert Dunn; Marilyn Kehry; Thomas A Packard; John C Cambier; Fu-Tong Liu; Keith Lindor; Ross L Coppel; Aftab A Ansari; M Eric Gershwin
B cell depletion therapy exacerbates murine primary biliary cirrhosis.
Hepatology (Baltimore, Md.) 2011;53(2):527-35.
2011: Hiroyuki Hounoki; Reina Ogawa; Koichiro Shinoda; Hirofumi Taki; Koichi tsuneyama; Kazuyuki Tobe
Simultaneously developed polymyositis and autoimmune hepatitis.
BMJ case reports 2011;2011():.
2011: Koichi tsuneyama; Masaki Aburada; Yen-Chen Chen; Makoto Fujimoto; Seiichi Iizuka; Mitsunobu Nagata; Yoshiyuki Sasaki; Tsutomu Shimada; Wataru Suzuki; Shao-Yuan Chen
Advantages and disadvantages of hyperbaric oxygen treatment in mice with obesity hyperlipidemia and steatohepatitis.
TheScientificWorldJournal 2011;11():2124-35.
2011: Qi Zhao; Naotoshi Shibahara; Koichi tsuneyama; Kinzo Matsumoto; Feng Li; Ken Tanaka; Takeshi Miyata; Takako Yokozawa
Diabetes-induced central cholinergic neuronal loss and cognitive deficit are attenuated by tacrine and a Chinese herbal prescription, kangen-karyu: elucidation in type 2 diabetes db/db mice.
Journal of pharmacological sciences 2011;117(4):230-42.
2011: Qi Zhao; Takeshi Miyata; Naotoshi Shibahara; Ken Tanaka; Koichi tsuneyama; Takako Yokozawa; Kinzo Matsumoto
Chotosan (Diaoteng San)-induced improvement of cognitive deficits in senescence-accelerated mouse (SAMP8) involves the amelioration of angiogenic/neurotrophic factors and neuroplasticity systems in the brain.
Chinese medicine 2011;6():33.
2011: Hiroshi Oka; Hirozo Goto; Keiichi Koizumi; Shin Nakamura; Koichi tsuneyama; Yue Zhou; Michiko Jo; Takako Fujimoto; Hiroaki Sakurai; Naotoshi Shibahara; Ikuo Saiki; Yutaka Shimada
Effect of Hachimijiogan against Renal Dysfunction and Involvement of Hypoxia-Inducible Factor-1α in the Remnant Kidney Model.
Evidence-based complementary and alternative medicine : eCAM 2011;2011():348686.
2011: Yuki Moritoki; Masanobu Tsuda; Koichi tsuneyama; Weici Zhang; Katsunori Yoshida; Zhe-Xiong Lian; Guo-Xiang Yang; William M Ridgway; Linda S Wicker; Aftab A Ansari; M Eric Gershwin
B cells promote hepatic inflammation, biliary cyst formation, and salivary gland inflammation in the NOD.c3c4 model of autoimmune cholangitis.
Cellular immunology 2011;268(1):16-23.
2010: Qi Zhao; Takako Yokozawa; Noriko Yamabe; Koichi tsuneyama; Xiaohan Li; Kinzo Matsumoto
Kangen-karyu improves memory deficit caused by aging through normalization of neuro-plasticity-related signaling system and VEGF system in the brain.
Journal of ethnopharmacology 2010;131(2):377-85.
2010: Masanori Kobayashi; Satonori Higuchi; Katsuhiko Mizuno; Koichi tsuneyama; Tatsuki Fukami; Miki Nakajima; Tsuyoshi Yokoi
Interleukin-17 is involved in alpha-naphthylisothiocyanate-induced liver injury in mice.
Toxicology 2010;275(1-3):50-7.
2010: Kazuhiro Nomoto; Takashi Hori; Chieko Kiya; Junya Fukuoka; Akitoshi Nakashima; Takao Hidaka; Shigeru Saito; Yoshiki Mikami; Koichi tsuneyama; Yasuo Takano
Endometrioid adenocarcinoma of the vagina with a microglandular pattern arising from endometriosis after hysterectomy.
Pathology international 2010;60(9):636-41.
2010: Weici Zhang; Masanobu Tsuda; Guo-Xiang Yang; Koichi tsuneyama; Guanghua Rong; William M Ridgway; Aftab A Ansari; Richard A Flavell; Ross Coppel; Zhe-Xiong Lian; M Eric Gershwin
Deletion of interleukin-6 in mice with the dominant negative form of transforming growth factor beta receptor II improves colitis but exacerbates autoimmune cholangitis.
Hepatology (Baltimore, Md.) 2010;52(1):215-22.
2010: Hideki Hatta; Koichi tsuneyama; Takashi Kondo; Yasuo Takano
Development of an ultrasound-emitting device for performing rapid immunostaining procedures.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 2010;58(5):421-8.
2010: Chia-Ming Chang; Chia-Hui Lo; Yao-Ming Shih; Yin Chen; Ping-Yi Wu; Koichi tsuneyama; Steve R Roffler; Mi-Hua Tao
Treatment of hepatocellular carcinoma with adeno-associated virus encoding interleukin-15 superagonist.
Human gene therapy 2010;21(5):611-21.
2010: Yasuni Nakanuma; Yoh Zen; Kenichi Harada; Motoko Sasaki; Akitaka Nonomura; Takeshi Uehara; Kenji Sano; Fukuo Kondo; Toshio Fukusato; Koichi tsuneyama; Masahiro Ito; Kenichi Wakasa; Minoru Nomoto; Hiroshi Minato; Hironori Haga; Masayoshi Kage; Hirohisa Yano; Joji Haratake; Shinichi Aishima; Tomoyuki Masuda; Hajime Aoyama; Aya Miyakawa-Hayashino; Toshiharu Matsumoto; Hayato Sanefuji; Hidenori Ojima; Tse-Ching Chen; Eunsil Yu; Ji-Hun Kim; Young Nyun Park; Wilson Tsui
Application of a new histological staging and grading system for primary biliary cirrhosis to liver biopsy specimens: Interobserver agreement.
Pathology international 2010;60(3):167-74.
2010: Makoto Fujimoto; Koichi tsuneyama; Hideki Kinoshita; Hirozo Goto; Yasuo Takano; Carlo Selmi; Carl L Keen; M Eric Gershwin; Yutaka Shimada
The traditional Japanese formula keishibukuryogan reduces liver injury and inflammation in patients with nonalcoholic fatty liver disease.
Annals of the New York Academy of Sciences 2010;1190():151-8.
2010: Carlo Selmi; Koichi tsuneyama
Nutrition, geoepidemiology, and autoimmunity.
Autoimmunity reviews 2010;9(5):A267-70.
2010: Satuski Yasumura; Hideo Shojaku; Rinnosuke Wada; Yukio Watanabe; Hideo Shojaku; Hikaru Seto; Masaya Kawano; Koichi tsuneyama
Usefulness of Positron Emission Tomography for management of ocular sebaceous carcinoma.
Clinical nuclear medicine 2010;35(2):98-100.
2010: Shinji Shimoda; Kenichi Harada; Hiroaki Niiro; Akinobu Taketomi; Yoshihiko Maehara; Koichi tsuneyama; Kentaro Kikuchi; Yasuni Nakanuma; Ian R Mackay; M Eric Gershwin; Koichi Akashi
CX3CL1 (fractalkine): a signpost for biliary inflammation in primary biliary cirrhosis.
Hepatology (Baltimore, Md.) 2010;51(2):567-75.
2010: Shinji Nakada; Koichi tsuneyama; Ichiro Kato; Yoshiaki Tabuchi; Ichiro Takasaki; Yukihiro Furusawa; Hiroshi Kawaguchi; Makoto Fujimoto; Hirozo Goto; Hiroaki Hikiami; Takashi Kondo; Yasuo Takano; Yutaka Shimada
Identification of candidate genes involved in endogenous protection mechanisms against acute pancreatitis in mice.
Biochemical and biophysical research communications 2010;391(3):1342-7.
2010: Katsuhisa Omagari; Shigeko Kato; Koichi tsuneyama; Hideki Hatta; Miki Sato; Mizuho Hamasaki; Yukiko Sadakane; Takehiro Tashiro; Mitsue Fukuhata; Yuji Miyata; Shizuka Tamaru; Kazunari Tanaka; Masatoshi Mune
Olive leaf extract prevents spontaneous occurrence of non-alcoholic steatohepatitis in SHR/NDmcr-cp rats.
Pathology 2010;42(1):66-72.
2010: Mika Ito; Akitoshi Nakashima; Takao Hidaka; Motonori Okabe; Nguyen Duy Bac; Shihomi Ina; Satoshi Yoneda; Arihiro Shiozaki; Shigeki Sumi; Koichi tsuneyama; Toshio Nikaido; Shigeru Saito
A role for IL-17 in induction of an inflammation at the fetomaternal interface in preterm labour.
Journal of reproductive immunology 2010;84(1):75-85.
2009: Keiichi Koizumi; Yurika Saitoh; Takayuki Minami; Nobuhiro Takeno; Koichi tsuneyama; Tatsuro Miyahara; Takashi Nakayama; Hiroaki Sakurai; Yasuo Takano; Miyuki Nishimura; Toshio Imai; Osamu Yoshie; Ikuo Saiki
Role of CX3CL1/fractalkine in osteoclast differentiation and bone resorption.
Journal of immunology (Baltimore, Md. : 1950) 2009;183(12):7825-31.
2009: Yuki Moritoki; Zhe-Xiong Lian; Keith Lindor; Joseph M Tuscano; Koichi tsuneyama; Weici Zhang; Yoshiyuki Ueno; Robert Dunn; Marilyn Kehry; Ross L Coppel; Ian R Mackay; M Eric Gershwin
B-cell depletion with anti-CD20 ameliorates autoimmune cholangitis but exacerbates colitis in transforming growth factor-beta receptor II dominant negative mice.
Hepatology (Baltimore, Md.) 2009;50(6):1893-903.
2009: Yu Yamazaki; Koichi tsuneyama; Masaharu Urakaze; Isao Usui; Agussalim Bukhari; Shiho Fujisaka; Ryuji Hayashi; Kazuya Hirata; Shingo Imanishi; Manabu Ishiki; Yukiko Kanatani; Masashi Kobayashi; Yuji Matsuya; Hideo Nemoto; Satoko Senda; Hikari Suzuki; Kazuyuki Tobe
Treatment with SRT1720, a SIRT1 activator, ameliorates fatty liver with reduced expression of lipogenic enzymes in MSG mice.
American journal of physiology. Endocrinology and metabolism 2009;297(5):E1179-86.
2009: Shiho Fujisaka; Isao Usui; Agussalim Bukhari; Masashi Ikutani; Takeshi Oya; Yukiko Kanatani; Koichi tsuneyama; Yoshinori Nagai; Kiyoshi Takatsu; Masaharu Urakaze; Masashi Kobayashi; Kazuyuki Tobe
Regulatory mechanisms for adipose tissue M1 and M2 macrophages in diet-induced obese mice.
Diabetes 2009;58(11):2574-82.
2009: Katsunori Yoshida; Guo-Xiang Yang; Weici Zhang; Masanobu Tsuda; Koichi tsuneyama; Yuki Moritoki; Aftab A Ansari; Kazuichi Okazaki; Zhe-Xiong Lian; Ross L Coppel; Ian R Mackay; M Eric Gershwin
Deletion of interleukin-12p40 suppresses autoimmune cholangitis in dominant negative transforming growth factor beta receptor type II mice.
Hepatology (Baltimore, Md.) 2009;50(5):1494-500.
2009: Yukitaka Yoshikawa; Mayu Morita; Hiroko Hosomi; Koichi tsuneyama; Tatsuki Fukami; Miki Nakajima; Tsuyoshi Yokoi
Knockdown of superoxide dismutase 2 enhances acetaminophen-induced hepatotoxicity in rat.
Toxicology 2009;264(1-2):89-95.
2009: Eisuke Kobayashi; Masanori Kobayashi; Koichi tsuneyama; Tatsuki Fukami; Miki Nakajima; Tsuyoshi Yokoi
Halothane-induced liver injury is mediated by interleukin-17 in mice.
Toxicological sciences : an official journal of the Society of Toxicology 2009;111(2):302-10.
2009: Yoshiyuki Sasaki; Wataru Suzuki; Tsutomu Shimada; Seiichi Iizuka; Satoko Nakamura; Mitsunobu Nagata; Makoto Fujimoto; Koichi tsuneyama; Ryoji Hokao; Ken-Ichi Miyamoto; Masaki Aburada
Dose dependent development of diabetes mellitus and non-alcoholic steatohepatitis in monosodium glutamate-induced obese mice.
Life sciences 2009;85(13-14):490-8.
2009: Mayu Morita; Sho Akai; Hiroko Hosomi; Koichi tsuneyama; Miki Nakajima; Tsuyoshi Yokoi
Drug-induced hepatotoxicity test using gamma-glutamylcysteine synthetase knockdown rat.
Toxicology letters 2009;189(2):159-65.
2009: Hiroyuki Takahashi; Shigeharu Miwa; Kazuhiro Nomoto; Shinichi Hayashi; Koichi tsuneyama; Yasuo Takano
Peribiliary cyst of common bile duct: possible cause of refractory jaundice.
Pathology international 2009;59(9):692-3.
2009: W Zhang; Yuki Moritoki; Koichi tsuneyama; Guo-Xiang Yang; Y Ilan; Zhe-Xiong Lian; M Eric Gershwin
Beta-glucosylceramide ameliorates liver inflammation in murine autoimmune cholangitis.
Clinical and experimental immunology 2009;157(3):359-64.
2009: Kazuto Tajiri; Yukihiro Shimizu; Koichi tsuneyama; Toshiro Sugiyama
Role of liver-infiltrating CD3+CD56+ natural killer T cells in the pathogenesis of nonalcoholic fatty liver disease.
European journal of gastroenterology & hepatology 2009;21(6):673-80.
2009: Ying-Yi Li; Yu Wu; Koichi tsuneyama; Tomohisa Baba; Naofumi Mukaida
Essential contribution of Ets-1 to constitutive Pim-3 expression in human pancreatic cancer cells.
Cancer science 2009;100(3):396-404.
2009: Yuki Moritoki; Weici Zhang; Koichi tsuneyama; Katsunori Yoshida; Kanji Wakabayashi; Guo-Xiang Yang; Christopher L Bowlus; William M Ridgway; Yoshiyuki Ueno; Aftab A Ansari; Ross Coppel; Ian R Mackay; Richard A Flavell; M Eric Gershwin; Zhe-Xiong Lian
B cells suppress the inflammatory response in a mouse model of primary biliary cirrhosis.
Gastroenterology 2009;136(3):1037-47.
2009: K Wakabayashi; K Yoshida; Patrick S C Leung; Yuki Moritoki; Guo-Xiang Yang; Koichi tsuneyama; Zhe-Xiong Lian; T Hibi; Aftab A Ansari; L S Wicker; William M Ridgway; Ross Coppel; Ian R Mackay; M Eric Gershwin
Induction of autoimmune cholangitis in non-obese diabetic (NOD).1101 mice following a chemical xenobiotic immunization.
Clinical and experimental immunology 2009;155(3):577-86.
2009: Ruth Y Lan; Thucydides L Salunga; Koichi tsuneyama; Zhe-Xiong Lian; Guo-Xiang Yang; Willy Hsu; Yuki Moritoki; Aftab A Ansari; Claudia Kemper; Jeff Price; John P Atkinson; Ross Coppel; M Eric Gershwin
Hepatic IL-17 responses in human and murine primary biliary cirrhosis.
Journal of autoimmunity 2009;32(1):43-51.
2009: Weici Zhang; Rahul Sharma; Shyr-Te Ju; Xiaosong He; Yanyan Tao; Koichi tsuneyama; Zhigang Tian; Zhe-Xiong Lian; Shu Man Fu; M Eric Gershwin
Deficiency in regulatory T cells results in development of antimitochondrial antibodies and autoimmune cholangitis.
Hepatology (Baltimore, Md.) 2009;49(2):545-52.
2009: Hikari Suzuki; Ichiro Kato; Isao Usui; Ichiro Takasaki; Yoshiaki Tabuchi; Takeshi Oya; Koichi tsuneyama; Hiroshi Kawaguchi; Koichi Hiraga; Shin Takasawa; Hiroshi Okamoto; Kazuyuki Tobe; Masakiyo Sasahara
Characterization of diabetic nephropathy in CaM kinase IIalpha (Thr286Asp) transgenic mice.
Biochemical and biophysical research communications 2009;379(1):38-42.
2009: Willy Hsu; Weici Zhang; Koichi tsuneyama; Yuki Moritoki; William M Ridgway; Aftab A Ansari; Ross Coppel; Zhe-Xiong Lian; Ian Mackay; M Eric Gershwin
Differential mechanisms in the pathogenesis of autoimmune cholangitis versus inflammatory bowel disease in interleukin-2Ralpha(-/-) mice.
Hepatology (Baltimore, Md.) 2009;49(1):133-40.
2009: Takuya Ishibe; Akihiko Kimura; Yuko Ishida; Tatsunori Takayasu; Takahito Hayashi; Koichi tsuneyama; Kouji Matsushima; Ikuhiro Sakata; Naofumi Mukaida; Toshikazu Kondo
Reduced acetaminophen-induced liver injury in mice by genetic disruption of IL-1 receptor antagonist.
Laboratory investigation; a journal of technical methods and pathology 2009;89(1):68-79.
2008: Yuko Nakanishi; Koichi tsuneyama; Kazuhiro Nomoto; Makoto Fujimoto; Thucydides L Salunga; Takahiko Nakajima; Shigeharu Miwa; Yoshihiro Murai; Shinichi Hayashi; Ichiro Kato; Koichi Hiraga; Daniel K Hsu; Fu-Tong Liu; Yasuo Takano
Nonalcoholic steatohepatitis and hepatocellular carcinoma in galectin-3 knockout mice.
Hepatology research : the official journal of the Japan Society of Hepatology 2008;38(12):1241-51.
2008: Katsuhisa Omagari; Shigeko Kato; Koichi tsuneyama; Chisato Inohara; Yu Kuroda; Hiroe Tsukuda; Eri Fukazawa; Keiko Shiraishi; Masatoshi Mune
Effects of a long-term high-fat diet and switching from a high-fat to low-fat, standard diet on hepatic fat accumulation in Sprague-Dawley rats.
Digestive diseases and sciences 2008;53(12):3206-12.
2008: Kanji Wakabayashi; Zhe-Xiong Lian; Patrick S C Leung; Yuki Moritoki; Koichi tsuneyama; Mark J Kurth; Kit S Lam; Katsunori Yoshida; Guo-Xiang Yang; Toshifumi Hibi; Aftab A Ansari; William M Ridgway; Ross Coppel; Ian R Mackay; M Eric Gershwin
Loss of tolerance in C57BL/6 mice to the autoantigen E2 subunit of pyruvate dehydrogenase by a xenobiotic with ensuing biliary ductular disease.
Hepatology (Baltimore, Md.) 2008;48(2):531-40.
2008: Shigeko Kato; Katsuhisa Omagari; Koichi tsuneyama; Eri Fukazawa; Hiroe Tsukuda; Chisato Inohara; Yu Kuroda; Keiko Shiraishi; Masatoshi Mune
A possible rat model for non-alcoholic steatohepatitis: Histological findings in SHR/NDmcr-cp rats.
Hepatology research : the official journal of the Japan Society of Hepatology 2008;38(7):743-4.
2008: Jiro Ogawa; Hirokazu Kanegane; Koichi tsuneyama; Rika Kanezaki; Takeshi Futatani; Keiko Nomura; Shin Ishizawa; Masakiyo Sasahara; Etsuro Ito; Toshio Miyawaki
Platelet-derived growth factor may be associated with fibrosis in a Down syndrome patient with transient myeloproliferative disorder.
European journal of haematology 2008;81(1):58-64.
2008: Hekmat Osman Abdel-Aziz; Yoshihiro Murai; Ichiro Takasaki; Yoshiaki Tabuchi; Hua-Chuan Zheng; Kazuhiro Nomoto; Hiroyuki Takahashi; Koichi tsuneyama; Ichiro Kato; Daniel K Hsu; Fu-Tong Liu; Koichi Hiraga; Yasuo Takano
Targeted disruption of the galectin-3 gene results in decreased susceptibility to NNK-induced lung tumorigenesis: an oligonucleotide microarray study.
Journal of cancer research and clinical oncology 2008;134(7):777-88.
2008: Guo-Xiang Yang; Zhe-Xiong Lian; Ya-Hui Chuang; Yuki Moritoki; Ruth Y Lan; Kanji Wakabayashi; Aftab A Ansari; Richard A Flavell; William M Ridgway; Ross Coppel; Koichi tsuneyama; Ian R Mackay; M Eric Gershwin
Adoptive transfer of CD8(+) T cells from transforming growth factor beta receptor type II (dominant negative form) induces autoimmune cholangitis in mice.
Hepatology (Baltimore, Md.) 2008;47(6):1974-82.
2008: Tomohiko Kutsuna; Huachuan Zheng; Hekmat Osman Abdel-Aziz; Yoshihiro Murai; Koichi tsuneyama; Isao Furuta; Yasuo Takano
High JC virus load in tongue carcinomas may be a risk factor for tongue tumorigenesis.
Virchows Archiv : an international journal of pathology 2008;452(4):405-10.
2008: Hua-Chuan Zheng; Koichi tsuneyama; Hiroyuki Takahashi; Shigeharu Miwa; Toshiro Sugiyama; Boryana Konstantinova Popivanova; Chifumi Fujii; Kazuhiro Nomoto; Naofumi Mukaida; Yasuo Takano
Aberrant Pim-3 expression is involved in gastric adenoma-adenocarcinoma sequence and cancer progression.
Journal of cancer research and clinical oncology 2008;134(4):481-8.
2008: Yoshiharu Kawaguchi; Hirokazu Ishihara; Yumiko Abe; Shoji Seki; Ayano Tokunaga; Aya Urushizaki; Hiroyuki Takahashi; Koichi tsuneyama; Tomoatsu Kimura
Fatal prognosis of an atypical meningioma in the cervical spine.
Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association 2008;13(2):155-9.
2008: Makoto Fujimoto; Koichi tsuneyama; Mosaburo Kainuma; Nobuyasu Sekiya; Hirozo Goto; Yasuo Takano; Katsutoshi Terasawa; Carlo Selmi; M Eric Gershwin; Yutaka Shimada
Evidence-based efficacy of Kampo formulas in a model of non alcoholic fatty liver.
Experimental biology and medicine (Maywood, N.J.) 2008;233(3):328-37.
2008: Takuya Akashi; Keiichi Koizumi; Koichi tsuneyama; Ikuo Saiki; Yasuo Takano; Hideki Fuse
Chemokine receptor CXCR4 expression and prognosis in patients with metastatic prostate cancer.
Cancer science 2008;99(3):539-42.
2008: Shinji Shimoda; Kenichi Harada; Hiroaki Niiro; Tomoharu Yoshizumi; Yuji Soejima; Akinobu Taketomi; Yoshihiko Maehara; Koichi tsuneyama; Minoru Nakamura; Atsumasa Komori; Kiyoshi Migita; Yasuni Nakanuma; Hiromi Ishibashi; Carlo Selmi; M Eric Gershwin
Biliary epithelial cells and primary biliary cirrhosis: the role of liver-infiltrating mononuclear cells.
Hepatology (Baltimore, Md.) 2008;47(3):958-65.
2008: Yuko Nakanishi; Koichi tsuneyama; Makoto Fujimoto; Thucydides L Salunga; Kazuhiro Nomoto; Jun-Ling An; Yasuo Takano; Seiichi Iizuka; Mitsunobu Nagata; Wataru Suzuki; Tsutomu Shimada; Masaki Aburada; Masayuki Nakano; Carlo Selmi; M Eric Gershwin
Monosodium glutamate (MSG): a villain and promoter of liver inflammation and dysplasia.
Journal of autoimmunity 2008;30(1-2):42-50.
2008: Sabine Oertelt-Prigione; Tin K Mao; Carlo Selmi; Koichi tsuneyama; Aftab A Ansari; Ross Coppel; Pietro Invernizzi; Mauro Podda; M Eric Gershwin
Impaired indoleamine 2,3-dioxygenase production contributes to the development of autoimmunity in primary biliary cirrhosis.
Autoimmunity 2008;41(1):92-9.
2008: Kazuhiro Nomoto; Koichi tsuneyama; Hiroyuki Takahashi; Yoshihiro Murai; Yasuo Takano
Cytoplasmic fine granular expression of 8-hydroxydeoxyguanosine reflects early mitochondrial oxidative DNA damage in nonalcoholic fatty liver disease.
Applied immunohistochemistry & molecular morphology : AIMM / official publication of the Society for Applied Immunohistochemistry 2008;16(1):71-5.
2007: Ichiro Nozaki; Takuo Watanabe; Makoto Kawaguchi; Hiroyasu Akatsu; Koichi tsuneyama; Yasuhiko Yamamoto; Kazuyo Ohe; Hideto Yonekura; Masahito Yamada; Hiroshi Yamamoto
Reduced expression of endogenous secretory receptor for advanced glycation endproducts in hippocampal neurons of Alzheimer's disease brains.
Archives of histology and cytology 2007;70(5):279-90.
2007: Huachuan Zheng; Hiroyuki Takahashi; Yoshihiro Murai; Zhengguo Cui; Kazuhiro Nomoto; Koichi tsuneyama; Yasuo Takano
Low expression of FHIT and PTEN correlates with malignancy of gastric carcinomas: tissue-array findings.
Applied immunohistochemistry & molecular morphology : AIMM / official publication of the Society for Applied Immunohistochemistry 2007;15(4):432-40.
2007: Hekmat Osman Abdel-Aziz; Yoshihiro Murai; Mei Hong; Tomohiko Kutsuna; Hiroyuki Takahashi; Kazuhiro Nomoto; Shuichi Murata; Koichi tsuneyama; Yasuo Takano
Detection of the JC virus genome in lung cancers: possible role of the T-antigen in lung oncogenesis.
Applied immunohistochemistry & molecular morphology : AIMM / official publication of the Society for Applied Immunohistochemistry 2007;15(4):394-400.
2007: Atsushi Tanaka; Koichi tsuneyama; Masaki Mikami; Satoko Uegaki; Mitsuhiko Aiso; Hajime Takikawa
Gene expression profiling in whole liver of bile duct ligated rats: VEGF-A expression is up-regulated in hepatocytes adjacent to the portal tracts.
Journal of gastroenterology and hepatology 2007;22(11):1993-2000.
2007: Takahito Hayashi; Naho Hirayama; Ayako Ro; Norimasa Kageyama; Yuko Ishida; Koichi tsuneyama; Akihiko Kimura; Tatsushige Fukunaga; Toshikazu Kondo
Severe brainstem compression by an unruptured giant vertebral aneurysm--an autopsy case.
Legal medicine (Tokyo, Japan) 2007;9(6):322-5.
2007: Tomoko Miyashita; Takahito Hayashi; Yuko Ishida; Koichi tsuneyama; Akihiko Kimura; Toshikazu Kondo
A fatal case of pontine hemorrhage related to methamphetamine abuse.
Journal of forensic and legal medicine 2007;14(7):444-7.
2007: Thucydides L Salunga; Yoshiaki Tabuchi; Ichiro Takasaki; Loreto Feril; Qing-Li Zhao; Kenzo Ohtsuka; Koichi tsuneyama; Takashi Kondo
Identification of genes responsive to paeoniflorin, a heat shock protein-inducing compound, in human leukemia U937 cells.
International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group 2007;23(6):529-37.
2007: Hiroyuki Takahashi; Yoshihiro Murai; Koichi tsuneyama; Kazuhiro Nomoto; Eikichi Okada; Hideharu Fujita; Yasuo Takano
High labeling indices of cdc25B is linked to progression of gastric cancers and associated with a poor prognosis.
Applied immunohistochemistry & molecular morphology : AIMM / official publication of the Society for Applied Immunohistochemistry 2007;15(3):267-72.
2007: Thucydides L Salunga; Zheng-Guo Cui; Shinji Shimoda; Hua-Chuan Zheng; Kazuhiro Nomoto; Takashi Kondo; Yasuo Takano; Carlo Selmi; Gianfranco Alpini; M Eric Gershwin; Koichi tsuneyama
Oxidative stress-induced apoptosis of bile duct cells in primary biliary cirrhosis.
Journal of autoimmunity 2007;29(2-3):78-86.
2007: Sho Akai; Hiroko Hosomi; Keiichi Minami; Koichi tsuneyama; Miki Katoh; Miki Nakajima; Tsuyoshi Yokoi
Knock down of gamma-glutamylcysteine synthetase in rat causes acetaminophen-induced hepatotoxicity.
The Journal of biological chemistry 2007;282(33):23996-4003.
2007: Patrick S C Leung; Ogyi Park; Koichi tsuneyama; Mark J Kurth; Kit S Lam; Aftab A Ansari; Ross Coppel; M Eric Gershwin
Induction of primary biliary cirrhosis in guinea pigs following chemical xenobiotic immunization.
Journal of immunology (Baltimore, Md. : 1950) 2007;179(4):2651-7.
2007: Miao Yu; Huachuan Zheng; Koichi tsuneyama; Hiroyuki Takahashi; Kazuhiro Nomoto; Huimian Xu; Yasuo Takano
Paradoxical expression of maspin in gastric carcinomas: correlation with carcinogenesis and progression.
Human pathology 2007;38(8):1248-55.
2007: Huachuan Zheng; Hekmat Osman Abdel-Aziz; Y Nakanishi; Shinji Masuda; Hiroshi Saito; Koichi tsuneyama; Yasuo Takano
Oncogenic role of JC virus in lung cancer.
The Journal of pathology 2007;212(3):306-15.
2007: Huachuan Zheng; Yoshihiro Murai; Mei Hong; Yuko Nakanishi; Kazuhiro Nomoto; Shinji Masuda; Koichi tsuneyama; Yasuo Takano
JC [corrected] virus detection in human tissue specimens.
Journal of clinical pathology 2007;60(7):787-93.
2007: Akihiko Takeuchi; Yasuhiko Yamamoto; Koichi tsuneyama; Chunmei Cheng; Hideto Yonekura; Takuo Watanabe; Katsuji Shimizu; Katsuro Tomita; Hiroshi Yamamoto; Hiroyuki Tsuchiya
Endogenous secretory receptor for advanced glycation endproducts as a novel prognostic marker in chondrosarcoma.
Cancer 2007;109(12):2532-40.
2007: Shozo Hojo; Keiichi Koizumi; Koichi tsuneyama; Yoshihisa Arita; Zhengguo Cui; Kanna Shinohara; Takayuki Minami; Isaya Hashimoto; Takashi Nakayama; Hiroaki Sakurai; Yasuo Takano; Osamu Yoshie; Kazuhiro Tsukada; Ikuo Saiki
High-level expression of chemokine CXCL16 by tumor cells correlates with a good prognosis and increased tumor-infiltrating lymphocytes in colorectal cancer.
Cancer research 2007;67(10):4725-31.
2007: Boryana K Popivanova; Ying-Yi Li; Huachuan Zheng; Kenji Omura; Chifumi Fujii; Koichi tsuneyama; Naofumi Mukaida
Proto-oncogene, Pim-3 with serine/threonine kinase activity, is aberrantly expressed in human colon cancer cells and can prevent Bad-mediated apoptosis.
Cancer science 2007;98(3):321-8.
2007: Huachuan Zheng; Hiroyuki Takahashi; Yoshihiro Murai; Zhengguo Cui; Kazuhiro Nomoto; Shigeharu Miwa; Koichi tsuneyama; Yasuo Takano
Pathobiological characteristics of intestinal and diffuse-type gastric carcinoma in Japan: an immunostaining study on the tissue microarray.
Journal of clinical pathology 2007;60(3):273-7.
2007: Hekmat Osman Abdel-Aziz; Ichiro Takasaki; Yoshiaki Tabuchi; Kazuhiro Nomoto; Yoshihiro Murai; Koichi tsuneyama; Yasuo Takano
High-density oligonucleotide microarrays and functional network analysis reveal extended lung carcinogenesis pathway maps and multiple interacting genes in NNK [4-(methylnitrosamino)-1-(3-pyridyle)-1-butanone] induced CD1 mouse lung tumor.
Journal of cancer research and clinical oncology 2007;133(2):107-15.
2007: Huachuan Zheng; Koichi tsuneyama; Chunmei Cheng; Hiroyuki Takahashi; Zhengguo Cui; Yoshihiro Murai; Kazhiro Nomoto; Yasuo Takano
Maspin expression was involved in colorectal adenoma-adenocarcinoma sequence and liver metastasis of tumors.
Anticancer research 2007;27(1A):259-65.
2007: Huachuan Zheng; Koichi tsuneyama; Hiroyuki Takahashi; Shigeharu Miwa; Kazuhiro Nomoto; Hiroshi Saito; Shinji Masuda; Yasuo Takano
Expression of PTEN and FHIT is involved in regulating the balance between apoptosis and proliferation in lung carcinomas.
Anticancer research 2007;27(1B):575-81.
2007: Yoshihiro Murai; Hua-Chuan Zheng; Hekmat Osman Abdel-Aziz; Hong Mei; Tomohiko Kutsuna; Yuko Nakanishi; Koichi tsuneyama; Yasuo Takano
High JC virus load in gastric cancer and adjacent non-cancerous mucosa.
Cancer science 2007;98(1):25-31.
2007: Huachuan Zheng; Koichi tsuneyama; Chunmei Cheng; Hiroyuki Takahashi; Zhengguo Cui; Kazuhiro Nomoto; Yoshihiro Murai; Yasuo Takano
Expression of KAI1 and tenascin, and microvessel density are closely correlated with liver metastasis of gastrointestinal adenocarcinoma.
Journal of clinical pathology 2007;60(1):50-6.
2006: Kazuhiro Nomoto; Koichi tsuneyama; Hekmat Osman Abdel-Aziz; Hiroyuki Takahashi; Yoshihiro Murai; Zheng-Guo Cui; M Fujimoto; Ichiro Kato; Koichi Hiraga; D K Hsu; Fu-Tong Liu; Yasuo Takano
Disrupted galectin-3 causes non-alcoholic fatty liver disease in male mice.
The Journal of pathology 2006;210(4):469-77.
2006: Huachuan Zheng; Hiroyuki Takahashi; Takahiko Nakajima; Yoshihiro Murai; Zhengguo Cui; Kazuhiro Nomoto; Koichi tsuneyama; Yasuo Takano
MUC6 down-regulation correlates with gastric carcinoma progression and a poor prognosis: an immunohistochemical study with tissue microarrays.
Journal of cancer research and clinical oncology 2006;132(12):817-23.
2006: Hua-Chuan Zheng; Hiroyuki Takahashi; Yoshihiro Murai; Zheng-Guo Cui; Kazuhiro Nomoto; Shigeharu Miwa; Koichi tsuneyama; Yasuo Takano
Upregulated EMMPRIN/CD147 might contribute to growth and angiogenesis of gastric carcinoma: a good marker for local invasion and prognosis.
British journal of cancer 2006;95(10):1371-8.
2006: hiroto kita; Yuichi Hikichi; Kouki Hikami; Koichi tsuneyama; Zheng-Guo Cui; Hiroyuki Osawa; Hirohide Ohnishi; Hiroyuki Mutoh; Hiroko Hoshino; Christopher L Bowlus; Hironori Yamamoto; Kentaro Sugano
Differential gene expression between flat adenoma and normal mucosa in the colon in a microarray analysis.
Journal of gastroenterology 2006;41(11):1053-63.
2006: Kanji Wakabayashi; Zhe-Xiong Lian; Yuki Moritoki; Ruth Y Lan; Koichi tsuneyama; Ya-Hui Chuang; Guo-Xiang Yang; William M Ridgway; Yoshiyuki Ueno; Aftab A Ansari; Ross Coppel; Ian R Mackay; M Eric Gershwin
IL-2 receptor alpha(-/-) mice and the development of primary biliary cirrhosis.
Hepatology (Baltimore, Md.) 2006;44(5):1240-9.
2006: Kazuto Tajiri; Yukihiro Shimizu; Koichi tsuneyama; Toshiro Sugiyama
A case report of oxidative stress in a patient with anorexia nervosa.
The International journal of eating disorders 2006;39(7):616-8.
2006: Mosaburo Kainuma; Makoto Fujimoto; Nobuyasu Sekiya; Koichi tsuneyama; Chunmei Cheng; Yasuo Takano; Katsutoshi Terasawa; Yutaka Shimada
Cholesterol-fed rabbit as a unique model of nonalcoholic, nonobese, non-insulin-resistant fatty liver disease with characteristic fibrosis.
Journal of gastroenterology 2006;41(10):971-80.
2006: Anchalee Sistayanarain; Koichi tsuneyama; Huachuan Zheng; Hiroyuki Takahashi; Kazuhiro Nomoto; Chunmei Cheng; Yoshihiro Murai; Atsushi Tanaka; Yasuo Takano
Expression of Aurora-B kinase and phosphorylated histone H3 in hepatocellular carcinoma.
Anticancer research 2006;26(5A):3585-93.
2006: Huachuan Zheng; Hiroyuki Takahashi; Yoshihiro Murai; Zhengguo Cui; Kazuhiro Nomoto; Hideki Niwa; Koichi tsuneyama; Yasuo Takano
Expressions of MMP-2, MMP-9 and VEGF are closely linked to growth, invasion, metastasis and angiogenesis of gastric carcinoma.
Anticancer research 2006;26(5A):3579-83.
2006: Khin Mar Myint; Yasuhiko Yamamoto; Toshio Doi; Ichiro Kato; Ai Harashima; Hideto Yonekura; Takuo Watanabe; Harumichi Shinohara; Masayoshi Takeuchi; Koichi tsuneyama; Noriyoshi Hashimoto; Masahide Asano; Shin Takasawa; Hiroshi Okamoto; Hiroshi Yamamoto
RAGE control of diabetic nephropathy in a mouse model: effects of RAGE gene disruption and administration of low-molecular weight heparin.
Diabetes 2006;55(9):2510-22.
2006: Hiroyuki Takahashi; Yoshihiro Murai; Koichi tsuneyama; Kazuhiro Nomoto; Eikichi Okada; Hideharu Fujita; Yasuo Takano
Overexpression of phosphorylated histone H3 is an indicator of poor prognosis in gastric adenocarcinoma patients.
Applied immunohistochemistry & molecular morphology : AIMM / official publication of the Society for Applied Immunohistochemistry 2006;14(3):296-302.
2006: Ya-Hui Chuang; Zhe-Xiong Lian; Koichi tsuneyama; Bor-Luen Chiang; Aftab A Ansari; Ross Coppel; M Eric Gershwin
Increased killing activity and decreased cytokine production in NK cells in patients with primary biliary cirrhosis.
Journal of autoimmunity 2006;26(4):232-40.
2006: Ai Harashima; Yasuhiko Yamamoto; Chunmei Cheng; Koichi tsuneyama; Khin Mar Myint; Akihiko Takeuchi; Kazunobu Yoshimura; Hui Li; Takuo Watanabe; Shin Takasawa; Hiroshi Okamoto; Hideto Yonekura; Hiroshi Yamamoto
Identification of mouse orthologue of endogenous secretory receptor for advanced glycation end-products: structure, function and expression.
The Biochemical journal 2006;396(1):109-15.
2006: Huachuan Zheng; Koichi tsuneyama; Chunmei Cheng; Hiroyuki Takahashi; Zhengguo Cui; Yoshihiro Murai; Kazuhiro Nomoto; Yasuo Takano
An immunohistochemical study of P53 and Ki-67 in gastrointestinal adenoma and adenocarcinoma using tissue microarray.
Anticancer research 2006;26(3B):2353-60.
2006: Ruth Y Lan; Chunmei Cheng; Zhe-Xiong Lian; Koichi tsuneyama; Guo-Xiang Yang; Yuki Moritoki; Ya-Hui Chuang; Takafumi Nakamura; Shigeru Saito; Shinji Shimoda; Atsushi Tanaka; Christopher L Bowlus; Yasuo Takano; Aftab A Ansari; Ross Coppel; M Eric Gershwin
Liver-targeted and peripheral blood alterations of regulatory T cells in primary biliary cirrhosis.
Hepatology (Baltimore, Md.) 2006;43(4):729-37.
2006: Yuko Ishida; Toshikazu Kondo; Akihiko Kimura; Koichi tsuneyama; Tatsunori Takayasu; Naofumi Mukaida
Opposite roles of neutrophils and macrophages in the pathogenesis of acetaminophen-induced acute liver injury.
European journal of immunology 2006;36(4):1028-38.
2006: Hideki Abe; Koichi tsuneyama; Kazuhiro Tsukada; Makuuchi Masatoshi
Five-year survival following a medial pancreatectomy for an invasive ductal carcinoma from the body of the pancreas.
World journal of gastroenterology : WJG 2006;12(5):822-4.
2006: Masakuni Noguchi; Mitsuharu Earashi; Hisatake Fujii; Koichi Yokoyama; Ken-ichi Harada; Koichi tsuneyama
Radiofrequency ablation of small breast cancer followed by surgical resection.
Journal of surgical oncology 2006;93(2):120-8.
2006: Chunmei Cheng; Koichi tsuneyama; Huachuan Zheng; Takeshi Oya; Zhengguo Cui; Loreto Feril; Yasuo Takano
Enhanced scavenging of lipid substances is a possible effect of corticosteroids in the treatment of cholesterol crystal embolism.
Pathology, research and practice 2006;202(8):591-8.
2006: Hideki Hatta; Koichi tsuneyama; Tokimasa Kumada; Huachuan Zheng; Chunmei Cheng; Zhengguo Cui; Hiroyuki Takahashi; Kazuhiro Nomoto; Yoshihiro Murai; Yasuo Takano
Freshly prepared immune complexes with intermittent microwave irradiation result in rapid and high-quality immunostaining.
Pathology, research and practice 2006;202(6):439-45.
2006: Kazuhiro Nomoto; Koichi tsuneyama; Chunmei Cheng; Hiroyuki Takahashi; Ryota Hori; Yoshihiro Murai; Yasuo Takano
Intrahepatic cholangiocarcinoma arising in cirrhotic liver frequently expressed p63-positive basal/stem-cell phenotype.
Pathology, research and practice 2006;202(2):71-6.
2006: Mei Hong; Yoshihiro Murai; Tomohiko Kutsuna; Hiroyuki Takahashi; Kazuhiro Nomoto; Chun-Mei Cheng; Shin Ishizawa; Qing-Li Zhao; Ryohei Ogawa; Brian V Harmon; Koichi tsuneyama; Yasuo Takano
Suppression of Epstein-Barr nuclear antigen 1 (EBNA1) by RNA interference inhibits proliferation of EBV-positive Burkitt's lymphoma cells.
Journal of cancer research and clinical oncology 2006;132(1):1-8.
2005: Taketoshi Yoshida; Hirokazu Kanegane; Keisuke Otsubo; Keiko Nomura; Shinichiro Hirokawa; Koichi tsuneyama; Hiroto Egawa; Toshio Miyawaki
Acute lymphoblastic leukemia after living donor liver transplantation.
Pediatrics international : official journal of the Japan Pediatric Society 2005;47(5):579-82.
2005: Ryouta Hori; Yoshihiro Murai; Koichi tsuneyama; Hekmat Osman Abdel-Aziz; Kazuhiro Nomoto; Hiroyuki Takahashi; Chun-Mei Cheng; Tomohiko Kuchina; Brian V Harman; Yasuo Takano
Detection of JC virus DNA sequences in colorectal cancers in Japan.
Virchows Archiv : an international journal of pathology 2005;447(4):723-30.
2005: Chunmei Cheng; Koichi tsuneyama; Rieko Kominami; Harumichi Shinohara; Shigeru Sakurai; Hideto Yonekura; Takuo Watanabe; Yasuo Takano; Hiroshi Yamamoto; Yasuhiko Yamamoto
Expression profiling of endogenous secretory receptor for advanced glycation end products in human organs.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 2005;18(10):1385-96.
2005: Ya-Hui Chuang; Zhe-Xiong Lian; Chun-Mei Cheng; Ruth Y Lan; Guo-Xiang Yang; Yuki Moritoki; Bor-Luen Chiang; Aftab A Ansari; Koichi tsuneyama; Ross Coppel; M Eric Gershwin
Increased levels of chemokine receptor CXCR3 and chemokines IP-10 and MIG in patients with primary biliary cirrhosis and their first degree relatives.
Journal of autoimmunity 2005;25(2):126-32.
2005: Chun-Mei Cheng; Koichi tsuneyama; Kazuhiro Matsui; Hiroyuki Takahashi; Shin Ishizawa; Yasuo Takano
Cytoplasmic expression of c-erbB2 in non-small cell lung cancers.
Virchows Archiv : an international journal of pathology 2005;446(6):596-603.
2005: Satoshi Kitagawa; Yoh Zen; Kenichi Harada; Motoko Sasaki; Yasunori Sato; Hiroshi Minato; Kishichiro Watanabe; Hiroshi Kurumaya; Kazuyoshi Katayanagi; Shinji Masuda; Hideki Niwa; Koichi tsuneyama; Katsuhiko Saito; Joji Haratake; Kiyoshi Takagawa; Yasuni Nakanuma
Abundant IgG4-positive plasma cell infiltration characterizes chronic sclerosing sialadenitis (Küttner's tumor).
The American journal of surgical pathology 2005;29(6):783-91.
2005: Chifumi Fujii; Yasunari Nakamoto; Peirong Lu; Koichi tsuneyama; Boryana K Popivanova; Shuichi Kaneko; Naofumi Mukaida
Aberrant expression of serine/threonine kinase Pim-3 in hepatocellular carcinoma development and its role in the proliferation of human hepatoma cell lines.
International journal of cancer. Journal international du cancer 2005;114(2):209-18.
2005: Yoh Zen; Kenichi Harada; Motoko Sasaki; Koichi tsuneyama; Kazuhiro Matsui; Joji Haratake; Shotaro Sakisaka; Shiro Maeyama; Kazuhide Yamamoto; Masayuki Nakano; Kazuhide Shimamatsu; Masayoshi Kage; Nozomu Kurose; Akio Uchiyama; Yasuharu Kaizaki; Gotaro Toda; Yasuni Nakanuma
Are bile duct lesions of primary biliary cirrhosis distinguishable from those of autoimmune hepatitis and chronic viral hepatitis? Interobserver histological agreement on trimmed bile ducts.
Journal of gastroenterology 2005;40(2):164-70.
2005: Yoshihiro Murai; Shinichi Hayashi; Hiroyuki Takahashi; Koichi tsuneyama; Yasuo Takano
Correlation between DNA alterations and p53 and p16 protein expression in cancer cell lines.
Pathology, research and practice 2005;201(2):109-15.
2004: Yoh Zen; Kenichi Harada; Motoko Sasaki; Yasunori Sato; Koichi tsuneyama; Joji Haratake; Hiroshi Kurumaya; Kazuyoshi Katayanagi; Shinji Masuda; Hideki Niwa; Hideo Morimoto; Atsuo Miwa; Akio Uchiyama; Bernard C Portmann; Yasuni Nakanuma
IgG4-related sclerosing cholangitis with and without hepatic inflammatory pseudotumor, and sclerosing pancreatitis-associated sclerosing cholangitis: do they belong to a spectrum of sclerosing pancreatitis?
The American journal of surgical pathology 2004;28(9):1193-203.
2004: Tokimasa Kumada; Koichi tsuneyama; Hideki Hatta; Shin Ishizawa; Yasuo Takano
Improved 1-h rapid immunostaining method using intermittent microwave irradiation: practicability based on 5 years application in Toyama Medical and Pharmaceutical University Hospital.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 2004;17(9):1141-9.
2004: Koichi tsuneyama; Motoko Sasaki; Tomonori Shimonishi; Yasuni Nakanuma
Expression of MAGE-A3 in intrahepatic cholangiocarcinoma and its precursor lesions.
Pathology international 2004;54(3):181-6.
2004: Motoko Sasaki; Koichi tsuneyama; Takahito Saito; Hiroaki Kataoka; Jan Mollenhauer; Annemarie Poustka; Yasuni Nakanuma
Site-characteristic expression and induction of trefoil factor family 1, 2 and 3 and malignant brain tumor-1 in normal and diseased intrahepatic bile ducts relates to biliary pathophysiology.
Liver international : official journal of the International Association for the Study of the Liver 2004;24(1):29-37.
2004: Yuko Ishida; Toshikazu Kondo; Koichi tsuneyama; Peirong Lu; Tatsunori Takayasu; Naofumi Mukaida
The pathogenic roles of tumor necrosis factor receptor p55 in acetaminophen-induced liver injury in mice.
Journal of leukocyte biology 2004;75(1):59-67.
2003: Motoko Sasaki; Koichi tsuneyama; Akira Ishikawa; Yasuni Nakanuma
Intrahepatic cholangiocarcinoma in cirrhosis presents granulocyte and granulocyte-macrophage colony-stimulating factor.
Human pathology 2003;34(12):1337-44.
2003: Takashi Kamihira; Shinji Shimoda; Kenichi Harada; Akira Kawano; Mizuki Handa; Eishi Baba; Koichi tsuneyama; Minoru Nakamura; Hiromi Ishibashi; Yasuni Nakanuma; M Eric Gershwin; Mine Harada
Distinct costimulation dependent and independent autoreactive T-cell clones in primary biliary cirrhosis.
Gastroenterology 2003;125(5):1379-87.
2003: Motoko Sasaki; Koichi tsuneyama; Yasuni Nakanuma
Aberrant expression of trefoil factor family 1 in biliary epithelium in hepatolithiasis and cholangiocarcinoma.
Laboratory investigation; a journal of technical methods and pathology 2003;83(10):1403-13.
2003: Motoko Sasaki; Shiu-Feng Huang; Miin-Fu Chen; Yi-Yin Jan; Ta-Sen Yeh; Akira Ishikawa; Jan Mollenhauer; Annemarie Poustka; Koichi tsuneyama; Yuji Nimura; Koji Oda; Yasuni Nakanuma
Decrease of deleted in malignant brain tumour-1 (DMBT-1) expression is a crucial late event in intrahepatic cholangiocarcinoma.
Histopathology 2003;43(4):340-6.
2003: Motoko Sasaki; Shiu-Feng Huang; Miin-Fu Chen; Yi-Yin Jan; Ta-Sen Yeh; Akira Ishikawa; Jan Mollenhauer; Annemarie Poustka; Koichi tsuneyama; Yuji Nimura; Koji Oda; Yasuni Nakanuma
Expression of deleted in malignant brain tumor-1 (DMBT1) molecule in biliary epithelium is augmented in hepatolithiasis: possible participation in lithogenesis.
Digestive diseases and sciences 2003;48(7):1234-40.
2003: Koichi tsuneyama; K Ohba; Yoh Zen; Yasunori Sato; H Niwa; Hiroshi Minato; Yasuni Nakanuma
A comparative histological and morphometric study of vascular changes in idiopathic portal hypertension and alcoholic fibrosis/cirrhosis.
Histopathology 2003;43(1):55-61.
2003: Kenichi Harada; Kumiko Isse; Koichi tsuneyama; Hajime Ohta; Yasuni Nakanuma
Accumulating CD57 + CD3 + natural killer T cells are related to intrahepatic bile duct lesions in primary biliary cirrhosis.
Liver international : official journal of the International Association for the Study of the Liver 2003;23(2):94-100.
2003: Koichi tsuneyama; Yasuharu Kaizaki; Kenji Doden; Eiichi Kidani; Kenichi Harada; Motoko Sasaki; Yasuni Nakanuma
Combined hepatocellular and cholangiocarcinoma with marked squamous cell carcinoma components arising in non-cirrhotic liver.
Pathology international 2003;53(2):90-7.
2003: Kenichi Harada; Satoru Ozaki; Yoshiko Sudo; Koichi tsuneyama; Hajime Ohta; Yasuni Nakanuma
Osteopontin is involved in the formation of epithelioid granuloma and bile duct injury in primary biliary cirrhosis.
Pathology international 2003;53(1):8-17.
2002: Yoh Zen; Hajime Sunagozaka; Koichi tsuneyama; Kekichi Masutomi; Shuichi Terasaki; Shuichi Kaneko; Kenichi Kobayashi; Yasuni Nakanuma
Incomplete septal cirrhosis associated with Wegener's granulomatosis.
Liver 2002;22(5):388-93.
2002: Yoh Zen; Kenichi Harada; Motoko Sasaki; Koichi tsuneyama; Kazuyoshi Katayanagi; Yui Yamamoto; Yasuni Nakanuma
Lipopolysaccharide induces overexpression of MUC2 and MUC5AC in cultured biliary epithelial cells: possible key phenomenon of hepatolithiasis.
The American journal of pathology 2002;161(4):1475-84.
2002: Koichi tsuneyama; Kenichi Harada; Naoko Kono; Motoko Sasaki; Takahito Saito; M Eric Gershwin; Mamoru Ikemoto; Hiroyuki Arai; Yasuni Nakanuma
Damaged interlobular bile ducts in primary biliary cirrhosis show reduced expression of glutathione-S-transferase-pi and aberrant expression of 4-hydroxynonenal.
Journal of hepatology 2002;37(2):176-83.
2002: Koichi tsuneyama; Kenichi Harada; Kazuyoshi Katayanagi; Kishichiro Watanabe; Hiroshi Kurumaya; Hiroshi Minato; Yasuni Nakanuma
Overlap of idiopathic portal hypertension and scleroderma: report of two autopsy cases and a review of literature.
Journal of gastroenterology and hepatology 2002;17(2):217-23.
2002: Koichi tsuneyama; Wataru Kouda; Yasuni Nakanuma
Portal and parenchymal alterations of the liver in idiopathic portal hypertension: a histological and immunochemical study.
Pathology, research and practice 2002;198(9):597-603.
2002: Takahito Saito; Kenichi Harada; Koichi tsuneyama; Masaaki Hirano; Susumu Amaya; Motoko Sasaki; Shuichi Kaneko; Kenichi Kobayashi; Yasuni Nakanuma
Primary squamous cell carcinoma of the liver producing parathyroid hormone-related protein.
Journal of gastroenterology 2002;37(2):138-42.
2001: Yoshiko Sudo; Kenichi Harada; Koichi tsuneyama; Kazuyoshi Katayanagi; Yoh Zen; Yasuni Nakanuma
Oncocytic biliary cystadenocarcinoma is a form of intraductal oncocytic papillary neoplasm of the liver.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 2001;14(12):1304-9.
2001: Koichi tsuneyama; Kenichi Harada; Naoko Kono; Katsushi Hiramatsu; Yoh Zen; Yoshiko Sudo; M Eric Gershwin; M Ikemoto; H Arai; Yasuni Nakanuma
Scavenger cells with gram-positive bacterial lipoteichoic acid infiltrate around the damaged interlobular bile ducts of primary biliary cirrhosis.
Journal of hepatology 2001;35(2):156-63.
2001: Koichi tsuneyama; M Nose; M Nisihara; Kazuyoshi Katayanagi; Kenichi Harada; Yasuni Nakanuma
Spontaneous occurrence of chronic non-suppurative destructive cholangitis and antimitochondrial autoantibodies in MRL/lpr mice: possible animal model for primary biliary cirrhosis.
Pathology international 2001;51(6):418-24.
2001: Susumu Amaya; Motoko Sasaki; Y Watanabe; Wilson M S Tsui; Koichi tsuneyama; Kenichi Harada; Yasuni Nakanuma
Expression of MUC1 and MUC2 and carbohydrate antigen Tn change during malignant transformation of biliary papillomatosis.
Histopathology 2001;38(6):550-60.
2001: H Sabit; Koichi tsuneyama; Tomonori Shimonishi; Kenichi Harada; J Cheng; H Ida; T Saku; K Saito; Yasuni Nakanuma
Enhanced expression of basement-membrane-type heparan sulfate proteoglycan in tumor fibro-myxoid stroma of intrahepatic cholangiocarcinoma.
Pathology international 2001;51(4):248-56.
2001: Kenichi Harada; Koichi tsuneyama; Yoshiko Sudo; Shinji Masuda; Yasuni Nakanuma
Molecular identification of bacterial 16S ribosomal RNA gene in liver tissue of primary biliary cirrhosis: is Propionibacterium acnes involved in granuloma formation?
Hepatology (Baltimore, Md.) 2001;33(3):530-6.
2001: Kenichi Harada; Satoru Ozaki; Naoko Kono; Koichi tsuneyama; Kazuyoshi Katayanagi; Katsushi Hiramatsu; Yasuni Nakanuma
Frequent molecular identification of Campylobacter but not Helicobacter genus in bile and biliary epithelium in hepatolithiasis.
The Journal of pathology 2001;193(2):218-23.
2001: Yoh Zen; Kazuyoshi Katayanagi; Koichi tsuneyama; K Harada; I Araki; Y Nakanuma
Hepatocellular carcinoma arising in non-alcoholic steatohepatitis.
Pathology international 2001;51(2):127-31.
2001: Yasuni Nakanuma; Koichi tsuneyama; Kenichi Harada
Pathology and pathogenesis of intrahepatic bile duct loss.
Journal of hepato-biliary-pancreatic surgery 2001;8(4):303-15.
2001: Yasuni Nakanuma; Koichi tsuneyama; M Ohbu; Kazuyoshi Katayanagi
Pathology and pathogenesis of idiopathic portal hypertension with an emphasis on the liver.
Pathology, research and practice 2001;197(2):65-76.
2001: Koichi tsuneyama; Kenichi Harada; Mitsue Yasoshima; Katsushi Hiramatsu; C R Mackay; I R Mackay; M Eric Gershwin; Yasuni Nakanuma
Monocyte chemotactic protein-1, -2, and -3 are distinctively expressed in portal tracts and granulomata in primary biliary cirrhosis: implications for pathogenesis.
The Journal of pathology 2001;193(1):102-9.
2000: Tomonori Shimonishi; Kumiko Isse; Fumie Shibata; I Aburatani; Koichi tsuneyama; H Sabit; Kenichi Harada; K Miyazaki; Yasuni Nakanuma
Up-regulation of fas ligand at early stages and down-regulation of Fas at progressed stages of intrahepatic cholangiocarcinoma reflect evasion from immune surveillance.
Hepatology (Baltimore, Md.) 2000;32(4 Pt 1):761-9.
2000: Yasuni Nakanuma; Koichi tsuneyama; Motoko Sasaki; Kenichi Harada
Destruction of bile ducts in primary biliary cirrhosis.
Baillière's best practice & research. Clinical gastroenterology 2000;14(4):549-70.
2000: Wataru Koda; Kenichi Harada; Koichi tsuneyama; Naoko Kono; Motoko Sasaki; Osamu Matsui; Yasuni Nakanuma
Evidence of the participation of peribiliary mast cells in regulation of the peribiliary vascular plexus along the intrahepatic biliary tree.
Laboratory investigation; a journal of technical methods and pathology 2000;80(7):1007-17.
2000: Katsushi Hiramatsu; Kenichi Harada; Koichi tsuneyama; Motoko Sasaki; S Fujita; T Hashimoto; Shuichi Kaneko; K i Kobayashi; Yasuni Nakanuma
Amplification and sequence analysis of partial bacterial 16S ribosomal RNA gene in gallbladder bile from patients with primary biliary cirrhosis.
Journal of hepatology 2000;33(1):9-18.
2000: M Iwata; Kenichi Harada; Katsushi Hiramatsu; Koichi tsuneyama; Shuichi Kaneko; K i Kobayashi; Yasuni Nakanuma
Fas ligand expressing mononuclear cells around intrahepatic bile ducts co-express CD68 in primary biliary cirrhosis.
Liver 2000;20(2):129-35.
2000: Koichi tsuneyama; K Saito; B H Ruebner; I Konishi; Y Nakanuma; M Eric Gershwin
Immunological similarities between primary sclerosing cholangitis and chronic sclerosing sialadenitis: report of the overlapping of these two autoimmune diseases.
Digestive diseases and sciences 2000;45(2):366-72.
2000: Mitsue Yasoshima; Koichi tsuneyama; Kenichi Harada; Motoko Sasaki; M Eric Gershwin; Yasuni Nakanuma
Immunohistochemical analysis of cell-matrix adhesion molecules and their ligands in the portal tracts of primary biliary cirrhosis.
The Journal of pathology 2000;190(1):93-9.
1999: Kenichi Harada; Koichi tsuneyama; Katsushi Hiramatsu; Yasuni Nakanuma
Significance of CD30-positive lymphocytes in livers in primary biliary cirrhosis.
Journal of gastroenterology and hepatology 1999;14(12):1197-202.
1999: Koichi tsuneyama; Naoko Kono; Masashi Yamashiro; Wataru Kouda; A Sabit; Motoko Sasaki; Yasuni Nakanuma
Aberrant expression of stem cell factor on biliary epithelial cells and peribiliary infiltration of c-kit-expressing mast cells in hepatolithiasis and primary sclerosing cholangitis: a possible contribution to bile duct fibrosis.
The Journal of pathology 1999;189(4):609-14.
1999: Kenichi Harada; Yoshiko Sudo; Naoko Kono; Satoru Ozaki; Koichi tsuneyama; M Eric Gershwin; Yasuni Nakanuma
In situ nucleic acid detection of PDC-E2, BCOADC-E2, OGDC-E2, PDC-E1alpha, BCOADC-E1alpha, OGDC-E1, and the E3 binding protein (protein X) in primary biliary cirrhosis.
Hepatology (Baltimore, Md.) 1999;30(1):36-45.
1999: Stefano Quaranta; Howard M Shulman; Alaa Ahmed; Yehuda Shoenfeld; J Peter; G B McDonald; Judith A van de Water; Ross Coppel; Cecilia Ostlund; Howard J Worman; Mario Rizzetto; Koichi tsuneyama; Yasuni Nakanuma; Aftab A Ansari; F Locatelli; S Paganin; Floriano Rosina; M Manns; M Eric Gershwin
Autoantibodies in human chronic graft-versus-host disease after hematopoietic cell transplantation.
Clinical immunology (Orlando, Fla.) 1999;91(1):106-16.
1999: Koichi tsuneyama; M Hoso; Naoko Kono; M Kitagawa; Shinji Masuda; N Matsuki; Yasuni Nakanuma
An unusual case of epithelial-myoepithelial carcinoma of the liver.
The American journal of surgical pathology 1999;23(3):349-53.
1999: Yasuni Nakanuma; Kenichi Harada; Kazuyoshi Katayanagi; Koichi tsuneyama; Motoko Sasaki
Definition and pathology of primary sclerosing cholangitis.
Journal of hepato-biliary-pancreatic surgery 1999;6(4):333-42.
1999: Koichi tsuneyama; Motoko Sasaki; A Sabit; K Yokoi; Y Arano; T Imai; Yasuni Nakanuma
A case report of gastric carcinosarcoma with rhabdomyosarcomatous and neuroendocrinal differentiation.
Pathology, research and practice 1999;195(2):93-7; discussion 98.
1998: Masashi Yamashiro; Wataru Kouda; Naoko Kono; Koichi tsuneyama; Osamu Matsui; Yasuni Nakanuma
Distribution of intrahepatic mast cells in various hepatobiliary disorders. An immunohistochemical study.
Virchows Archiv : an international journal of pathology 1998;433(5):471-9.
1998: Koichi tsuneyama; Kenichi Harada; Mitsue Yasoshima; Kyosuke Kaji; M Eric Gershwin; Yasuni Nakanuma
Expression of co-stimulatory factor B7-2 on the intrahepatic bile ducts in primary biliary cirrhosis and primary sclerosing cholangitis: an immunohistochemical study.
The Journal of pathology 1998;186(2):126-30.
1998: Koichi tsuneyama; Mitsue Yasoshima; Kenichi Harada; Katsushi Hiramatsu; M Eric Gershwin; Yasuni Nakanuma
Increased CD1d expression on small bile duct epithelium and epithelioid granuloma in livers in primary biliary cirrhosis.
Hepatology (Baltimore, Md.) 1998;28(3):620-3.
1998: Kenichi Harada; Naoko Kono; Koichi tsuneyama; Yasuni Nakanuma
Cell-kinetic study of proliferating bile ductules in various hepatobiliary diseases.
Liver 1998;18(4):277-84.
1998: Koichi tsuneyama; Naoko Kono; M Hoso; H Sugahara; K Yoshida; Kazuyoshi Katayanagi; M Eric Gershwin; K Saito; Yasuni Nakanuma
aly/aly mice: a unique model of biliary disease.
Hepatology (Baltimore, Md.) 1998;27(6):1499-507.
1997: Yasuni Nakanuma; Kenichi Harada; Kyosuke Kaji; Shuichi Terasaki; Koichi tsuneyama; S Moteki; Judith A van de Water; Patrick S C Leung; M Eric Gershwin
Clinicopathological study of primary biliary cirrhosis negative for antimitochondrial antibodies.
Liver 1997;17(6):281-7.
1997: Kyosuke Kaji; Koichi tsuneyama; Yasuni Nakanuma; Kenichi Harada; Motoko Sasaki; Shuichi Kaneko; K i Kobayashi
B7-2 positive cells around interlobular bile ducts in primary biliary cirrhosis and chronic hepatitis C.
Journal of gastroenterology and hepatology 1997;12(7):507-12.
1997: Yasuni Nakanuma; Mitsue Yasoshima; Koichi tsuneyama; Kenichi Harada
Histopathology of primary biliary cirrhosis with emphasis on expression of adhesion molecules.
Seminars in liver disease 1997;17(1):35-47.
1997: Yuichi Takeoka; S Y Chen; RL Boyd; Koichi tsuneyama; N Taguchi; S Morita; Hisashi Yago; S Suehiro; Aftab A Ansari; Leonard D Shultz; M Eric Gershwin
A comparative analysis of the murine thymic microenvironment in normal, autoimmune, and immunodeficiency states.
Developmental immunology 1997;5(2):79-89.
1997: Koichi tsuneyama; Judith A van de Water; K Yamazaki; K Suzuki; Shinichi Sato; Y Takeda; B Ruebner; B A Yost; Yasuni Nakanuma; Ross Coppel; M Eric Gershwin
Primary biliary cirrhosis an epithelitis: evidence of abnormal salivary gland immunohistochemistry.
Autoimmunity 1997;26(1):23-31.
1996: S Cha; Patrick S C Leung; Judith A van de Water; Koichi tsuneyama; Ruth E Joplin; Aftab A Ansari; Yasuni Nakanuma; P J Schatz; Steven E Cwirla; Luca Fabris; James M Neuberger; M Eric Gershwin; Ross Coppel
Random phage mimotopes recognized by monoclonal antibodies against the pyruvate dehydrogenase complex-E2 (PDC-E2).
Proceedings of the National Academy of Sciences of the United States of America 1996;93(20):10949-54.
1996: M Hoso; Yasuni Nakanuma; M Kawano; K Oda; Koichi tsuneyama; Judith A van de Water; M Eric Gershwin
Granulomatous cholangitis in chronic hepatitis C: a new diagnostic problem in liver pathology.
Pathology international 1996;46(4):301-5.
1996: Koichi tsuneyama; Yasuni Nakanuma
[Biliary papillomatosis].
Ryōikibetsu shōkōgun shirīzu 1996;(9):81-4.
1995: Yasuni Nakanuma; Koichi tsuneyama; M Eric Gershwin; Mitsue Yasoshima
Pathology and immunopathology of primary biliary cirrhosis with emphasis on bile duct lesions: recent progress.
Seminars in liver disease 1995;15(4):313-28.
1995: Koichi tsuneyama; Judith A van de Water; D Van Thiel; Ross Coppel; Boris Henry Ruebner; Yasuni Nakanuma; E R Dickson; M Eric Gershwin
Abnormal expression of PDC-E2 on the apical surface of biliary epithelial cells in patients with antimitochondrial antibody-negative primary biliary cirrhosis.
Hepatology (Baltimore, Md.) 1995;22(5):1440-6.
1995: Koichi tsuneyama; Judith A van de Water; Patrick S C Leung; S Cha; Yasuni Nakanuma; M Kaplan; R De Lellis; Ross Coppel; Aftab A Ansari; M Eric Gershwin
Abnormal expression of the E2 component of the pyruvate dehydrogenase complex on the luminal surface of biliary epithelium occurs before major histocompatibility complex class II and BB1/B7 expression.
Hepatology (Baltimore, Md.) 1995;21(4):1031-7.
1995: Mitsue Yasoshima; Yasuni Nakanuma; Koichi tsuneyama; Judith A van de Water; M Eric Gershwin
Immunohistochemical analysis of adhesion molecules in the micro-environment of portal tracts in relation to aberrant expression of PDC-E2 and HLA-DR on the bile ducts in primary biliary cirrhosis.
The Journal of pathology 1995;175(3):319-25.
1995: Yasuni Nakanuma; Koichi tsuneyama; Naoko Kono; M Hoso; Judith A van de Water; M Eric Gershwin
Biliary epithelial expression of pyruvate dehydrogenase complex in primary biliary cirrhosis: an immunohistochemical and immunoelectron microscopic study.
Human pathology 1995;26(1):92-8.
1994: Kyosuke Kaji; Yasuni Nakanuma; Motoko Sasaki; M Unoura; K Kobayashi; Akitaka Nonomura; Koichi tsuneyama; Judith A van de Water; M Eric Gershwin
Hepatitic bile duct injuries in chronic hepatitis C: histopathologic and immunohistochemical studies.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 1994;7(9):937-45.
1994: Koichi tsuneyama; Judith A van de Water; Yasuni Nakanuma; S Cha; Aftab A Ansari; Ross Coppel; M Eric Gershwin
Human combinatorial autoantibodies and mouse monoclonal antibodies to PDC-E2 produce abnormal apical staining of salivary glands in patients with coexistent primary biliary cirrhosis and Sjögren's syndrome.
Hepatology (Baltimore, Md.) 1994;20(4 Pt 1):893-8.
1994: Yasuni Nakanuma; Koichi tsuneyama; S Masuda; T Tomioka
Hepatic inflammatory pseudotumor associated with chronic cholangitis: report of three cases.
Human pathology 1994;25(1):86-91.
1993: K Kizawa; Koichi tsuneyama; T Terada; Yasuni Nakanuma; U Miwa; H Kurumaya
[An autopsied case of primary hepatic malignant lymphoma associated with chronic active hepatitis C].
Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology 1993;90(9):2147-51.