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Andrei Kleschyov

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Andrei L Kleschyov; Vasily D Sen'
Heparin-polynitroxide derivatives: a platform for new diagnostic and therapeutic agents in cardiovascular disease?
Andrei L Kleschyov; Karl J Lackner; Kerstin Münnemann; Laura M Schreiber; Vasily Sen'; Maxim Terekhov; Stefan Weber; Valery Golubev; Dariush Hinderberger; Thomas Münzel
Heparin-polynitroxides: synthesis and preliminary evaluation as cardiovascular EPR/MR imaging probes and extracellular space-targeted antioxidants.
Swenja Kröller-Schön; Andreas Daiber; Marcus Hortmann; Andrei L Kleschyov; Matthias Oelze; Thomas Renné; Eberhard Schulz; Michael Torzewski; Philip Wenzel; Thomas Münzel
Differential effects of heart rate reduction with ivabradine in two models of endothelial dysfunction and oxidative stress.

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All Publications

2013: Andrei L Kleschyov; Vasily D Sen'
Heparin-polynitroxide derivatives: a platform for new diagnostic and therapeutic agents in cardiovascular disease?
Future medicinal chemistry 2013;5(4):385-8.
2012: Andrei L Kleschyov; Karl J Lackner; Kerstin Münnemann; Laura M Schreiber; Vasily Sen'; Maxim Terekhov; Stefan Weber; Valery Golubev; Dariush Hinderberger; Thomas Münzel
Heparin-polynitroxides: synthesis and preliminary evaluation as cardiovascular EPR/MR imaging probes and extracellular space-targeted antioxidants.
European journal of medicinal chemistry 2012;58():265-71.
2011: Swenja Kröller-Schön; Andreas Daiber; Marcus Hortmann; Andrei L Kleschyov; Matthias Oelze; Thomas Renné; Eberhard Schulz; Michael Torzewski; Philip Wenzel; Thomas Münzel
Differential effects of heart rate reduction with ivabradine in two models of endothelial dysfunction and oxidative stress.
Basic research in cardiology 2011;106(6):1147-58.
2011: Swenja Schuhmacher; Marc Foretz; Maike Knorr; Thomas Jansen; Marcus Hortmann; Philip Wenzel; Matthias Oelze; Andrei L Kleschyov; Andreas Daiber; John F Keaney; Gerhard Wegener; Karl Lackner; Thomas Münzel; Benoit Viollet; Eberhard Schulz
α1AMP-activated protein kinase preserves endothelial function during chronic angiotensin II treatment by limiting Nox2 upregulation.
Arteriosclerosis, thrombosis, and vascular biology 2011;31(3):560-6.
2010: Björn C Dollmann; Andrei L Kleschyov; Vasily Sen; Valery Golubev; Laura M Schreiber; Hans Wolfgang Spiess; Kerstin Münnemann; Dariush Hinderberger
Spin-labeled heparins as polarizing agents for dynamic nuclear polarization.
Chemphyschem : a European journal of chemical physics and physical chemistry 2010;11(17):3656-63.
2009: Bernd Mayer; Andrei L Kleschyov; Heike Stessel; Michael Russwurm; Thomas Münzel; Doris Koesling; Kurt Schmidt
Inactivation of soluble guanylate cyclase by stoichiometric S-nitrosation.
Molecular pharmacology 2009;75(4):886-91.
2008: Huige Li; Marcus Hortmann; Andreas Daiber; Matthias Oelze; Mir Abolfazl Ostad; Petra M Schwarz; Hui Xu; Ning Xia; Andrei L Kleschyov; Christian Mang; Ascan Warnholtz; Thomas Münzel; Ulrich Förstermann
Cyclooxygenase 2-selective and nonselective nonsteroidal anti-inflammatory drugs induce oxidative stress by up-regulating vascular NADPH oxidases.
The Journal of pharmacology and experimental therapeutics 2008;326(3):745-53.
2008: Alexander Jabs; Sebastian Göbel; Philip Wenzel; Andrei L Kleschyov; Marcus Hortmann; Matthias Oelze; Andreas Daiber; Thomas Münzel
Sirolimus-induced vascular dysfunction. Increased mitochondrial and nicotinamide adenosine dinucleotide phosphate oxidase-dependent superoxide production and decreased vascular nitric oxide formation.
Journal of the American College of Cardiology 2008;51(22):2130-8.
2007: Andrei L Kleschyov; Philip Wenzel; Thomas Munzel
Electron paramagnetic resonance (EPR) spin trapping of biological nitric oxide.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2007;851(1-2):12-20.
2007: Michael Torzewski; Viola Ochsenhirt; Andrei L Kleschyov; Matthias Oelze; Andreas Daiber; Huige Li; Heidi Rossmann; Sotirios Tsimikas; Kurt Reifenberg; Fei Cheng; Hans-Anton Lehr; Stefan Blankenberg; Ulrich Förstermann; Thomas Münzel; Karl J Lackner
Deficiency of glutathione peroxidase-1 accelerates the progression of atherosclerosis in apolipoprotein E-deficient mice.
Arteriosclerosis, thrombosis, and vascular biology 2007;27(4):850-7.
2007: Shiwei Deng; Anke Kruger; Andrei L Kleschyov; Leszek Kalinowski; Andreas Daiber; Leszek Wojnowski
Gp91phox-containing NAD(P)H oxidase increases superoxide formation by doxorubicin and NADPH.
Free radical biology & medicine 2007;42(4):466-73.
2007: Philip Wenzel; Ulrich Hink; Matthias Oelze; A Seeling; T Isse; Kai Bruns; L Steinhoff; M Brandt; Andrei L Kleschyov; Eberhard Schulz; K Lange; Henry Weiner; Jochen Lehmann; Karl J Lackner; T Kawamoto; Thomas Münzel; Andreas Daiber
Number of nitrate groups determines reactivity and potency of organic nitrates: a proof of concept study in ALDH-2-/- mice.
British journal of pharmacology 2007;150(4):526-33.
2006: Michael August; Oliver Wingerter; Matthias Oelze; Philip Wenzel; Andrei L Kleschyov; Andreas Daiber; Alexander Mülsch; Thomas Münzel; Nikolaos B Tsilimingas
Mechanisms underlying dysfunction of carotid arteries in genetically hyperlipidemic rabbits.
Nitric oxide : biology and chemistry / official journal of the Nitric Oxide Society 2006;15(3):241-51.
2006: Matthias Oelze; Andreas Daiber; Ralf P Brandes; Marcus Hortmann; Philip Wenzel; Ulrich Hink; Eberhard Schulz; Hanke Mollnau; Alexandra von Sandersleben; Andrei L Kleschyov; Alexander Mülsch; Huige Li; Ulrich Förstermann; Thomas Münzel
Nebivolol inhibits superoxide formation by NADPH oxidase and endothelial dysfunction in angiotensin II-treated rats.
Hypertension 2006;48(4):677-84.
2006: Matthias Oelze; Ascan Warnholtz; Jörg Faulhaber; Philip Wenzel; Andrei L Kleschyov; Meike Coldewey; Ulrich Hink; Olaf Pongs; Ingrid Fleming; Sven Wassmann; Thomas Meinertz; Heimo Ehmke; Andreas Daiber; Thomas Münzel
NADPH oxidase accounts for enhanced superoxide production and impaired endothelium-dependent smooth muscle relaxation in BKbeta1-/- mice.
Arteriosclerosis, thrombosis, and vascular biology 2006;26(8):1753-9.
2006: Andrei L Kleschyov; Susanne Strand; Steffen Schmitt; Daniela Gottfried; Michael Skatchkov; Nikolajs Sjakste; Andreas Daiber; Victor Umansky; Thomas Munzel
Dinitrosyl-iron triggers apoptosis in Jurkat cells despite overexpression of Bcl-2.
Free radical biology & medicine 2006;40(8):1340-8.
2005: Hanke Mollnau; Matthias Oelze; Michael August; Maria Wendt; Andreas Daiber; Eberhard Schulz; Stephan Baldus; Andrei L Kleschyov; Anke Materne; Philip Wenzel; Ulrich Hink; Georg Nickenig; Ingrid Fleming; Thomas Münzel
Mechanisms of increased vascular superoxide production in an experimental model of idiopathic dilated cardiomyopathy.
Arteriosclerosis, thrombosis, and vascular biology 2005;25(12):2554-9.
2005: Maria C Wendt; Andreas Daiber; Andrei L Kleschyov; Alexander Mülsch; Karsten Sydow; Eberhard Schulz; Kai Chen; John F Keaney; Bernard Lassègue; Ulrich Walter; Kathy K Griendling; Thomas Münzel
Differential effects of diabetes on the expression of the gp91phox homologues nox1 and nox4.
Free radical biology & medicine 2005;39(3):381-91.
2005: Petra Beranova; Christa Schott; Karel Chalupsky; Andrei L Kleschyov; Jean-Claude Stoclet; Bernard Muller
Role of the adventitia in the cyclic GMP-mediated relaxant effect of N-hydroxy-L-arginine in rat aorta.
Journal of vascular research 2005;42(4):331-6.
2005: Petra Beranova; Karel Chalupsky; Andrei L Kleschyov; Christa Schott; Jean-Luc Boucher; Daniel Mansuy; Thomas Munzel; Bernard Muller; Jean-Claude Stoclet
Nomega-hydroxy-L-arginine homologues and hydroxylamine as nitric oxide-dependent vasorelaxant agents.
European journal of pharmacology 2005;516(3):260-7.
2004: Andreas Daiber; Matthias Oelze; Meike Coldewey; Markus Bachschmid; Philip Wenzel; Karsten Sydow; Maria Wendt; Andrei L Kleschyov; Dirk Stalleicken; Volker Ullrich; Alexander Mülsch; Thomas Münzel
Oxidative stress and mitochondrial aldehyde dehydrogenase activity: a comparison of pentaerythritol tetranitrate with other organic nitrates.
Molecular pharmacology 2004;66(6):1372-82.
2004: Nikolajs Sjakste; Andrei L Kleschyov; Jean-Luc Boucher; Larisa Baumane; Maija Dzintare; Dainuvite Meirena; Jelizaveta Sjakste; Karsten Sydow; Thomas Münzel; Ivars Kalvinsh
Endothelium- and nitric oxide-dependent vasorelaxing activities of gamma-butyrobetaine esters: possible link to the antiischemic activities of mildronate.
European journal of pharmacology 2004;495(1):67-73.
2004: Andreas Daiber; Matthias Oelze; Michael August; Maria Wendt; Karsten Sydow; Hartwig Wieboldt; Andrei L Kleschyov; Thomas Munzel
Detection of superoxide and peroxynitrite in model systems and mitochondria by the luminol analogue L-012.
Free radical research 2004;38(3):259-69.
2004: Andreas Daiber; Michael August; Stephan Baldus; Maria Wendt; Matthias Oelze; Karsten Sydow; Andrei L Kleschyov; Thomas Munzel
Measurement of NAD(P)H oxidase-derived superoxide with the luminol analogue L-012.
Free radical biology & medicine 2004;36(1):101-11.
2003: Andrei L Kleschyov; Matthias Oelze; Andreas Daiber; Yale Huang; Hanke Mollnau; Eberhard Schulz; Karsten Sydow; Birgit Fichtlscherer; Alexander Mülsch; Thomas Münzel
Does nitric oxide mediate the vasodilator activity of nitroglycerin?
Circulation research 2003;93(9):e104-12.
2003: Hanke Mollnau; Eberhard Schulz; Andreas Daiber; Stephan Baldus; Matthias Oelze; Michael August; Maria Wendt; Ulrich Walter; Carolin Geiger; Rahul Agrawal; Andrei L Kleschyov; Thomas Meinertz; Thomas Münzel
Nebivolol prevents vascular NOS III uncoupling in experimental hyperlipidemia and inhibits NADPH oxidase activity in inflammatory cells.
Arteriosclerosis, thrombosis, and vascular biology 2003;23(4):615-21.
2002: Thomas Münzel; Igor B Afanas'ev; Andrei L Kleschyov; David G Harrison
Detection of superoxide in vascular tissue.
Arteriosclerosis, thrombosis, and vascular biology 2002;22(11):1761-8.
2002: Thomas Münzel; Alexander Mülsch; Andrei L Kleschyov
Mechanisms underlying nitroglycerin-induced superoxide production in platelets: some insight, more questions.
Circulation 2002;106(2):170-2.
2002: Andrei L Kleschyov; Maria Wendt; Thomas Munzel
Heme oxygenase-1-mediated protection: potential role of nonheme iron-nitric oxide complexes.
Circulation 2002;105(25):e196; author reply e196.
2002: Bernard Muller; Andrei L Kleschyov; Jacicarlos L Alencar; Anatoly F Vanin; Jean-Claude Stoclet
Nitric oxide transport and storage in the cardiovascular system.
Annals of the New York Academy of Sciences 2002;962():131-9.
2002: Hanke Mollnau; Maria Wendt; Katalin Szöcs; Bernard Lassègue; Eberhard Schulz; Matthias Oelze; Huige Li; Martin Bodenschatz; Michael August; Andrei L Kleschyov; Nikolaos B Tsilimingas; Ulrich Walter; Ulrich Förstermann; Thomas Meinertz; Kathy K Griendling; Thomas Münzel
Effects of angiotensin II infusion on the expression and function of NAD(P)H oxidase and components of nitric oxide/cGMP signaling.
Circulation research 2002;90(4):E58-65.
2002: Andrei L Kleschyov; Thomas Münzel
Advanced spin trapping of vascular nitric oxide using colloid iron diethyldithiocarbamate.
Methods in enzymology 2002;359():42-51.
2002: Andrei L Kleschyov; Gilles Hubert; Thomas Munzel; Jean-Claude Stoclet; Bernard Bucher
Low molecular mass dinitrosyl nonheme-iron complexes up-regulate noradrenaline release in the rat tail artery.
BMC pharmacology 2002;2():3.
2000: Grégory Giannone; Kenneth Takeda; Andrei L Kleschyov; A L Kleyschov
Novel activation of non-selective cationic channels by dinitrosyl iron-thiosulfate in PC12 cells.
The Journal of physiology 2000;529 Pt 3():735-45.
2000: Andrei L Kleschyov; Bernard Muller; Thérèse Keravis; Marie-Elisabeth Stoeckel; Jean-Claude Stoclet
Adventitia-derived nitric oxide in rat aortas exposed to endotoxin: cell origin and functional consequences.
American journal of physiology. Heart and circulatory physiology 2000;279(6):H2743-51.
2000: Andrei L Kleschyov; Hanke Mollnau; Matthias Oelze; Thomas Meinertz; Y Huang; David G Harrison; Thomas Munzel
Spin trapping of vascular nitric oxide using colloid Fe(II)-diethyldithiocarbamate.
Biochemical and biophysical research communications 2000;275(2):672-7.
2000: Bernard Muller; Andrei L Kleschyov; K Gyorgy; Jean-Claude Stoclet
Inducible NO synthase activity in blood vessels and heart: new insight into cell origin and consequences.
Physiological research / Academia Scientiarum Bohemoslovaca 2000;49(1):19-26.
1999: Jean-Claude Stoclet; Andrei L Kleschyov; Emile Andriambeloson; Myriam Diebolt; Ramaroson Andriantsitohaina
Endothelial no release caused by red wine polyphenols.
Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 1999;50(4):535-40.
1999: K György; Bernard Muller; A Vegh; Andrei L Kleschyov; Jean-Claude Stoclet
Triggering role of nitric oxide in the delayed protective effect of monophosphoryl lipid A in rat heart.
British journal of pharmacology 1999;127(8):1892-8.
1999: Frederik A C Wiegant; I Yu Malyshev; Andrei L Kleschyov; Ernst E van Faassen; Anatoly F Vanin
Dinitrosyl iron complexes with thiol-containing ligands and S-nitroso-D,L-penicillamine as inductors of heat shock protein synthesis in H35 hepatoma cells.
FEBS letters 1999;455(1-2):179-82.
1999: Jean-Claude Stoclet; M Carmen Martínez; P Ohlmann; Sylvette Chasserot; Christa Schott; Andrei L Kleschyov; F Schneider; Ramaroson Andriantsitohaina
Induction of nitric oxide synthase and dual effects of nitric oxide and cyclooxygenase products in regulation of arterial contraction in human septic shock.
Circulation 1999;100(2):107-12.
1999: Jean-Claude Stoclet; Bernard Muller; K György; R Andriantsiothaina; Andrei L Kleschyov
The inducible nitric oxide synthase in vascular and cardiac tissue.
European journal of pharmacology 1999;375(1-3):139-55.
1998: Jean-Claude Stoclet; E Troncy; Bernard Muller; C Brua; Andrei L Kleschyov
Molecular mechanisms underlying the role of nitric oxide in the cardiovascular system.
Expert opinion on investigational drugs 1998;7(11):1769-79.
1998: Jean-Claude Stoclet; B Muller; Ramaroson Andriantsitohaina; Andrei L Kleschyov
Overproduction of nitric oxide in pathophysiology of blood vessels.
Biochemistry. Biokhimii͡a 1998;63(7):826-32.
1998: Andrei L Kleschyov; Bernard Muller; Christa Schott; Jean-Claude Stoclet
Role of adventitial nitric oxide in vascular hyporeactivity induced by lipopolysaccharide in rat aorta.
British journal of pharmacology 1998;124(4):623-6.
1998: Bernard Muller; Andrei L Kleschyov; S Malblanc; Jean-Claude Stoclet
Nitric oxide-related cyclic GMP-independent relaxing effect of N-acetylcysteine in lipopolysaccharide-treated rat aorta.
British journal of pharmacology 1998;123(6):1221-9.
1998: Jean-Claude Stoclet; Ramaroson Andriantsitohaina; Andrei L Kleschyov; Bernard Muller
Nitric Oxide and cGMP in Regulation of Arterial Tone.
Trends in cardiovascular medicine 1998;8(1):14-9.
1997: V Martin; Andrei L Kleschyov; Jean-Paul Klein; Alain Beretz
Induction of nitric oxide production by polyosides from the cell walls of Streptococcus mutans OMZ 175, a gram-positive bacterium, in the rat aorta.
Infection and immunity 1997;65(6):2074-9.
1997: Emile Andriambeloson; Andrei L Kleschyov; Bernard Muller; Alain Beretz; Jean-Claude Stoclet; Ramaroson Andriantsitohaina
Nitric oxide production and endothelium-dependent vasorelaxation induced by wine polyphenols in rat aorta.
British journal of pharmacology 1997;120(6):1053-8.
1997: P Vetrovsky; Andrei L Kleschyov; Gustav Entlicher; P Poindron; Jean-Claude Stoclet
Nitric oxide generation from extracellularly applied NG-hydroxy-L-arginine in LPS-activated RAW 264 macrophages.
Biochimica et biophysica acta 1997;1334(1):51-6.
1997: V Martin; Andrei L Kleschyov; M Schöller; Jean-Paul Klein; Alain Beretz
Induction of NO production by polyosides from the wall of Streptococcus mutans OMZ175 in the rat aorta.
Advances in experimental medicine and biology 1997;418():669-72.
1996: Bernard Muller; Andrei L Kleschyov; Jean-Claude Stoclet
Evidence for N-acetylcysteine-sensitive nitric oxide storage as dinitrosyl-iron complexes in lipopolysaccharide-treated rat aorta.
British journal of pharmacology 1996;119(6):1281-5.
1994: Andrei L Kleschyov; K R Sedov; P I Mordvintcev; A F Vanin
Biotransformation of sodium nitroprusside into dinitrosyl iron complexes in tissue of ascites tumors of mice.
Biochemical and biophysical research communications 1994;202(1):168-73.