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Michael Albeck

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Miri Brodsky; Gilad Halpert; Michael Albeck; Benjamin Sredni
The anti-inflammatory effects of the tellurium redox modulating compound, AS101, are associated with regulation of NFkappaB signaling pathway and nitric oxide induction in macrophages.
Miri Brodsky; Shira Hirsh; Michael Albeck; Benjamin Sredni
Resolution of inflammation-related apoptotic processes by the synthetic tellurium compound, AS101 following liver injury.
Miriam Daniel-Hoffmann; Michael Albeck; Benjamin Sredni; Yeshayahu Nitzan
A potential antimicrobial treatment against ESBL-producing Klebsiella pneumoniae using the tellurium compound AS101.

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All Publications

2010: Miri Brodsky; Gilad Halpert; Michael Albeck; Benjamin Sredni
The anti-inflammatory effects of the tellurium redox modulating compound, AS101, are associated with regulation of NFkappaB signaling pathway and nitric oxide induction in macrophages.
Journal of inflammation (London, England) 2010;7(1):3.
2009: Miri Brodsky; Shira Hirsh; Michael Albeck; Benjamin Sredni
Resolution of inflammation-related apoptotic processes by the synthetic tellurium compound, AS101 following liver injury.
Journal of hepatology 2009;51(3):491-503.
2009: Miriam Daniel-Hoffmann; Michael Albeck; Benjamin Sredni; Yeshayahu Nitzan
A potential antimicrobial treatment against ESBL-producing Klebsiella pneumoniae using the tellurium compound AS101.
Archives of microbiology 2009;191(8):631-8.
2009: Inna Sinuani; Joshua Weissgarten; Ilia Beberashvili; Micha J Rapoport; Judith Sandbank; Leonid Feldman; Michael Albeck; Zhan Averbukh; Benjamin Sredni
The cyclin kinase inhibitor p57kip2 regulates TGF-beta-induced compensatory tubular hypertrophy: effect of the immunomodulator AS101.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 2009;24(8):2328-38.
2009: Michal Hayun; Hagar Saida; Michael Albeck; Alpha Peled; Nechama Haran-Ghera; Benjamin Sredni
Induction therapy in a multiple myeloma mouse model using a combination of AS101 and melphalan, and the activity of AS101 in a tumor microenvironment model.
Experimental hematology 2009;37(5):593-603.
2008: G M Frei; M Kremer; K-M Hanschmann; S Krause; Michael Albeck; Benjamin Sredni; B S Schnierle
Antitumour effects in mycosis fungoides of the immunomodulatory, tellurium-based compound, AS101.
The British journal of dermatology 2008;158(3):578-86.
2007: Sigal Yosef; Miri Brodsky; Benjamin Sredni; Amnon Albeck; Michael Albeck
Octa-O-bis-(R,R)-Tartarate Ditellurane (SAS) - a novel bioactive organotellurium(IV) compound: synthesis, characterization, and protease inhibitory activity.
ChemMedChem 2007;2(11):1601-6.
2007: Gabi M Frei; Ilana Lebenthal; Michael Albeck; Amnon Albeck; Benjamin Sredni
Neutral and positively charged thiols synergize the effect of the immunomodulator AS101 as a growth inhibitor of Jurkat cells, by increasing its uptake.
Biochemical pharmacology 2007;74(5):712-22.
2007: Eitan Okun; Thiruma V Arumugam; Sung-Chun Tang; Marc Gleichmann; Michael Albeck; Benjamin Sredni; Mark P Mattson
The organotellurium compound ammonium trichloro(dioxoethylene-0,0') tellurate enhances neuronal survival and improves functional outcome in an ischemic stroke model in mice.
Journal of neurochemistry 2007;102(4):1232-41.
2007: Michal Hayun; Eitan Okun; R Hayun; Uzi Gafter; Michael Albeck; Dan Longo; Benjamin Sredni
Synergistic effect of AS101 and Bryostatin-1 on myeloid leukemia cell differentiation in vitro and in an animal model.
Leukemia 2007;21(7):1504-13.
2007: Miri Brodsky; Sigal Yosef; Rushkin Galit; Michael Albeck; Dan Longo; Amnon Albeck; Benjamin Sredni
The synthetic tellurium compound, AS101, is a novel inhibitor of IL-1beta converting enzyme.
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 2007;27(6):453-62.
2007: Eitan Okun; Yahav Dikshtein; Alon Carmely; Hagar Saida; Gabi Frei; Ben-Ami Sela; Lydia Varshavsky; Asher Ofir; Esthy Levy; Michael Albeck; Benjamin Sredni
The organotellurium compound ammonium trichloro(dioxoethylene-o,o')tellurate reacts with homocysteine to form homocystine and decreases homocysteine levels in hyperhomocysteinemic mice.
The FEBS journal 2007;274(12):3159-70.
2007: Benjamin Sredni; Revital Geffen-Aricha; WENZHEN DUAN; Michael Albeck; Frances Shalit; Harry M Lander; Noa Kinor; Ortal Sagi; Amnon Albeck; Sigal Yosef; Miri Brodsky; Dvora Sredni-Kenigsbuch; Tali Sonino; Dan Longo; Mark P Mattson; Gal Yadid
Multifunctional tellurium molecule protects and restores dopaminergic neurons in Parkinson's disease models.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2007;21(8):1870-83.
2007: Rami Hayun; Sally Shpungin; Hana Malovani; Michael Albeck; Eitan Okun; Uri Nir; Benjamin Sredni
Novel involvement of the immunomodulator AS101 in IL-10 signaling, via the tyrosine kinase Fer.
Annals of the New York Academy of Sciences 2007;1095():240-50.
2006: Michal Hayun; Yaniv Naor; Merav Weil; Michael Albeck; Alpha Peled; Jeremy Don; Nechama Haran-Ghera; Benjamin Sredni
The immunomodulator AS101 induces growth arrest and apoptosis in multiple myeloma: association with the Akt/survivin pathway.
Biochemical pharmacology 2006;72(11):1423-31.
2006: Inna Sinuani; Zhan Averbukh; Inna Gitelman; Micha J Rapoport; Judith Sandbank; Michael Albeck; Benjamin Sredni; Joshua Weissgarten
Mesangial cells initiate compensatory renal tubular hypertrophy via IL-10-induced TGF-beta secretion: effect of the immunomodulator AS101 on this process.
American journal of physiology. Renal physiology 2006;291(2):F384-94.
2006: Eitan Okun; Hagar Saida; Michael Albeck; Benjamin Sredni; Ramy R Avtalion
Upregulation of carp GDNF mRNA by the immunomodulator AS101.
Developmental and comparative immunology 2006;30(5):441-6.
2004: Yona Kalechman; Uzi Gafter; Talia Weinstein; Avry Chagnac; Ilya Freidkin; Ana Tobar; Michael Albeck; Benjamin Sredni
Inhibition of interleukin-10 by the immunomodulator AS101 reduces mesangial cell proliferation in experimental mesangioproliferative glomerulonephritis: association with dephosphorylation of STAT3.
The Journal of biological chemistry 2004;279(23):24724-32.
2004: Benjamin Sredni; Merav Weil; Gennadi Khomenok; Ilana Lebenthal; Seagal Teitz-Tennenbaum; Yael Mardor; Zvi Ram; Arie Orenstein; Amir Kershenovich; Shalom Michowiz; Yan I Cohen; Z Harry Rappaport; Ilya Freidkin; Michael Albeck; Dan Longo; Yona Kalechman
Ammonium trichloro(dioxoethylene-o,o')tellurate (AS101) sensitizes tumors to chemotherapy by inhibiting the tumor interleukin 10 autocrine loop.
Cancer research 2004;64(5):1843-52.
2004: Benjamin Sredni; Rivka Gal; Ian Cohen; Jean-Eudes Dazard; David Givol; Uzi Gafter; Benny Motro; Siona Eliyahu; Michael Albeck; Harry M Lander; Yona Kalechman
Hair growth induction by the Tellurium immunomodulator AS101: association with delayed terminal differentiation of follicular keratinocytes and ras-dependent up-regulation of KGF expression.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2004;18(2):400-2.
2003: D Makarovsky; Yona Kalechman; T Sonino; Ilya Freidkin; Seagal Teitz-Tennenbaum; Michael Albeck; Merav Weil; Revital Geffen-Aricha; Gal Yadid; Benjamin Sredni
Tellurium compound AS101 induces PC12 differentiation and rescues the neurons from apoptotic death.
Annals of the New York Academy of Sciences 2003;1010():659-66.
2003: Yona Kalechman; Benjamin Sredni; Talia Weinstein; Ilya Freidkin; Ana Tobar; Michael Albeck; Uzi Gafter
Production of the novel mesangial autocrine growth factors GDNF and IL-10 is regulated by the immunomodulator AS101.
Journal of the American Society of Nephrology : JASN 2003;14(3):620-30.
2002: Yona Kalechman; Uzi Gafter; Rivka Gal; Galit Rushkin; Donghong Yan; Michael Albeck; Benjamin Sredni
Anti-IL-10 therapeutic strategy using the immunomodulator AS101 in protecting mice from sepsis-induced death: dependence on timing of immunomodulating intervention.
Journal of immunology (Baltimore, Md. : 1950) 2002;169(1):384-92.
2000: Yona Kalechman; Dan Longo; Raphael Catane; Adi Shani; Michael Albeck; Benjamin Sredni
Synergistic anti-tumoral effect of paclitaxel (Taxol)+AS101 in a murine model of B16 melanoma: association with ras-dependent signal-transduction pathways.
International journal of cancer. Journal international du cancer 2000;86(2):281-8.
1998: Yona Kalechman; G Strassmann; Michael Albeck; Benjamin Sredni
Up-regulation by ammonium trichloro(dioxoethylene-0,0') tellurate (AS101) of Fas/Apo-1 expression on B16 melanoma cells: implications for the antitumor effects of AS101.
Journal of immunology (Baltimore, Md. : 1950) 1998;161(7):3536-42.
1998: H Rosenblatt-Bin; Yona Kalechman; A Vonsover; R H Xu; J P Da; Frances Shalit; M Huberman; A Klein; G Strassmann; Michael Albeck; Benjamin Sredni
The immunomodulator AS101 restores T(H1) type of response suppressed by Babesia rodhaini in BALB/c mice.
Cellular immunology 1998;184(1):12-25.
1997: Yona Kalechman; Uzi Gafter; J P Da; Michael Albeck; D Alarcon-Segovia; Benjamin Sredni
Delay in the onset of systemic lupus erythematosus following treatment with the immunomodulator AS101: association with IL-10 inhibition and increase in TNF-alpha levels.
Journal of immunology (Baltimore, Md. : 1950) 1997;159(6):2658-67.
1996: Benjamin Sredni; T Tichler; Adi Shani; R Catane; B Kaufman; G Strassmann; Michael Albeck; Yona Kalechman
Predominance of TH1 response in tumor-bearing mice and cancer patients treated with AS101.
Journal of the National Cancer Institute 1996;88(18):1276-84.
1996: Yona Kalechman; Adi Shani; S Dovrat; J K Whisnant; K Mettinger; Michael Albeck; Benjamin Sredni
The antitumoral effect of the immunomodulator AS101 and paclitaxel (Taxol) in a murine model of lung adenocarcinoma.
Journal of immunology (Baltimore, Md. : 1950) 1996;156(3):1101-9.
1996: Benjamin Sredni; R H Xu; Michael Albeck; U Gafter; R Gal; Adi Shani; T Tichler; J Shapira; Israel Bruderman; R Catane; B Kaufman; J K Whisnant; K L Mettinger; Yona Kalechman
The protective role of the immunomodulator AS101 against chemotherapy-induced alopecia studies on human and animal models.
International journal of cancer. Journal international du cancer 1996;65(1):97-103.
1995: Yona Kalechman; G Rushkin; J Nerubay; Michael Albeck; Benjamin Sredni
Effect of the immunomodulator AS101 on chemotherapy-induced multilineage myelosuppression, thrombocytopenia, and anemia in mice.
Experimental hematology 1995;23(13):1358-66.
1995: Benjamin Sredni; Michael Albeck; T Tichler; Adi Shani; J Shapira; Israel Bruderman; R Catane; B Kaufman; Yona Kalechman
Bone marrow-sparing and prevention of alopecia by AS101 in non-small-cell lung cancer patients treated with carboplatin and etoposide.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 1995;13(9):2342-53.
1995: Yona Kalechman; A Zuloff; Michael Albeck; G Strassmann; Benjamin Sredni
Role of endogenous cytokines secretion in radioprotection conferred by the immunomodulator ammonium trichloro(dioxyethylene-0-0')tellurate.
Blood 1995;85(6):1555-61.
1995: Yona Kalechman; Adi Shani; Michael Albeck; Benjamin Sredni
Induction of acute phase proteins in mice and humans by treatment with AS101, an immunomodulator with radioprotective properties.
Immunopharmacology 1995;29(2):149-58.
1995: R H Xu; Yona Kalechman; Michael Albeck; Benjamin Sredni
The cytoprotective effect of the immunomodulator AS101 against hydrochloride induced gastric lesions.
Research communications in molecular pathology and pharmacology 1995;87(1):4-20.
1993: Yona Kalechman; Adi Shani; I Sotnik-Barkai; Michael Albeck; Benjamin Sredni
The protective role of ammonium trichloro(dioxoethylene-O,O')tellurate in combination with several cytotoxic drugs acting by different mechanisms of action.
Cancer research 1993;53(24):5962-9.
1993: Yona Kalechman; Adi Shani; Michael Albeck; I Sotnik Barkai; Benjamin Sredni
Increased DNA repair ability after irradiation following treatment with the immunomodulator AS101.
Radiation research 1993;136(2):197-204.
1993: Yona Kalechman; I Sotnik-Barkai; Michael Albeck; Benjamin Sredni
Protection of bone marrow stromal cells from the toxic effects of cyclophosphamide in vivo and of ASTA-Z 7557 and etoposide in vitro by ammonium trichloro(dioxyethylene-O-O')tellurate (AS101).
Cancer research 1993;53(8):1838-44.
1993: Yona Kalechman; U Gafter; I S Barkai; Michael Albeck; Benjamin Sredni
Mechanism of radioprotection conferred by the immunomodulator AS101.
Experimental hematology 1993;21(1):150-5.
1992: Yona Kalechman; I Sotnik-Barkai; Michael Albeck; Benjamin Sredni
The effect of AS101 on the reconstitution of T-cell reactivity following irradiation or cyclophosphamide treatment.
Experimental hematology 1992;20(11):1302-8.
1992: Yona Kalechman; Michael Albeck; Benjamin Sredni
In vivo synergistic effect of the immunomodulator AS101 and the PKC inducer bryostatin.
Cellular immunology 1992;143(1):143-53.
1992: Benjamin Sredni; Michael Albeck; Gila Kazimirsky; F Shalit
The immunomodulator AS101 administered orally as a chemoprotective and radioprotective agent.
International journal of immunopharmacology 1992;14(4):613-9.
1992: A Vonsover; Shoshana Loya; Benjamin Sredni; Michael Albeck; T Gotlieb-Stematsky; O Araf; Amnon Hizi
Inhibition of the reverse transcriptase activity and replication of human immunodeficiency virus type 1 by AS 101 in vitro.
AIDS research and human retroviruses 1992;8(5):613-23.
1992: L Kozenitzky; M David; B Sredai; Michael Albeck; B Shohat
Immunomodulatory effects of AS101 on interleukin-2 production and T-lymphocyte function of lymphocytes treated with psoralens and ultraviolet A.
Photodermatology, photoimmunology & photomedicine 1992;9(1):24-8.
1991: Yona Kalechman; I S Barkai; Michael Albeck; G Horwith; S N Sehagl; Benjamin Sredni
Use and mechanism of action of AS101 in protecting bone marrow colony forming units-granulocyte-macrophage following purging with ASTA-Z 7557.
Cancer research 1991;51(20):5614-20.
1991: Yona Kalechman; Michael Albeck; M Oron; D Sobelman; M Gurwith; G Horwith; T Kirsch; B Maida; S N Sehgal; Benjamin Sredni
Protective and restorative role of AS101 in combination with chemotherapy.
Cancer research 1991;51(5):1499-503.
1990: Yona Kalechman; Michael Albeck; M Oron; D Sobelman; M Gurwith; S N Seghal; Benjamin Sredni
Radioprotective effects of the immunomodulator AS101.
Journal of immunology (Baltimore, Md. : 1950) 1990;145(5):1512-7.
1990: Benjamin Sredni; Yona Kalechman; Michael Albeck; O Gross; D Aurbach; P Sharon; S N Sehgal; M J Gurwith; H Michlin
Cytokine secretion effected by synergism of the immunomodulator AS101 and the protein kinase C inducer bryostatin.
Immunology 1990;70(4):473-7.
1990: Benjamin Sredni; Yona Kalechman; F Shalit; Michael Albeck
Synergism between AS101 and PMA in lymphokine production.
Immunology 1990;69(1):110-6.
1989: Jorge Alcocer-Varela; D Alarcon-Segovia; Benjamin Sredni; Michael Albeck
Effect of the new immunoregulator AS-101 on in vitro functions of mononuclear cells from patients with systemic lupus erythematosus.
Clinical and experimental immunology 1989;77(3):319-23.
1988: Benjamin Sredni; R R Caspi; S Lustig; A Klein; Yona Kalechman; Y Danziger; M Ben Ya'akov; T Tamari; F Shalit; Michael Albeck
The biological activity and immunotherapeutic properties of AS-101, a synthetic organotellurium compound.
Natural immunity and cell growth regulation 1988;7(3):163-8.
1987: Benjamin Sredni; R R Caspi; A Klein; Yona Kalechman; Y Danziger; M Ben Ya'akov; T Tamari; F Shalit; Michael Albeck
A new immunomodulating compound (AS-101) with potential therapeutic application.
Nature 1987;330(6144):173-6.