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Edwin Chan

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Wan Ning Vanessa Chow; H Y Edwin Chan; Hon Wing Luk; Kwok-Fai Lau
Degradation of mutant huntingtin via the ubiquitin/proteasome system is modulated by FE65.
Jia-Hong Lu; Long Ma; Han-Ming Shen; Jie-Qiong Tan; Zhuo-Hua Zhang; H Y Edwin Chan; Siva Sundara Kumar Durairajan; Liang-Feng Liu; Min Li
Isorhynchophylline, a natural alkaloid, promotes the degradation of alpha-synuclein in neuronal cells via inducing autophagy.
Yan Hao; Candy Yan Hao; Michael S Perkinton; William Wai-Lun Chan; H Y Edwin Chan; Christopher C J Miller; Kwok-Fai Lau
GULP1 is a novel APP-interacting protein that alters APP processing.

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All Publications

2012: Wan Ning Vanessa Chow; H Y Edwin Chan; Hon Wing Luk; Kwok-Fai Lau
Degradation of mutant huntingtin via the ubiquitin/proteasome system is modulated by FE65.
The Biochemical journal 2012;443(3):681-9.
2012: Jia-Hong Lu; Long Ma; Han-Ming Shen; Jie-Qiong Tan; Zhuo-Hua Zhang; H Y Edwin Chan; Siva Sundara Kumar Durairajan; Liang-Feng Liu; Min Li
Isorhynchophylline, a natural alkaloid, promotes the degradation of alpha-synuclein in neuronal cells via inducing autophagy.
Autophagy 2012;8(1):98-108.
2011: Yan Hao; Candy Yan Hao; Michael S Perkinton; William Wai-Lun Chan; H Y Edwin Chan; Christopher C J Miller; Kwok-Fai Lau
GULP1 is a novel APP-interacting protein that alters APP processing.
The Biochemical journal 2011;436(3):631-9.
2010: Tat Cheung Cheng; Yu Wai Chen; Kam-Bo Wong; Sai-Ming Ngai; H Y Edwin Chan
Crystallization and preliminary crystallographic analysis of the central domain of Drosophila Dribble, a protein that is essential for ribosome biogenesis.
Acta crystallographica. Section F, Structural biology and crystallization communications 2010;66(Pt 5):546-8.
2009: Francesca K M Lee; Azaria K Y Wong; Yuk Wa Lee; Oi Wan Wan; H Y Edwin Chan; Kenny K K Chung
The role of ubiquitin linkages on alpha-synuclein induced-toxicity in a Drosophila model of Parkinson's disease.
Journal of neurochemistry 2009;110(1):208-19.
2008: Kwok-Fai Lau; Wing-Man Chan; Michael S Perkinton; Elizabeth L Tudor; Raymond Chuen-Chung Chang; H Y Edwin Chan; Declan McLoughlin; Christopher C J Miller
Dexras1 interacts with FE65 to regulate FE65-amyloid precursor protein-dependent transcription.
The Journal of biological chemistry 2008;283(50):34728-37.
2008: Jack Ho Wong; H Y Edwin Chan; Tzi Bun Ng
A mannose/glucose-specific lectin from Chinese evergreen chinkapin (Castanopsis chinensis).
Biochimica et biophysica acta 2008;1780(9):1017-22.
2008: S L Alan Wong; Wing Man Chan; H Y Edwin Chan
Sodium dodecyl sulfate-insoluble oligomers are involved in polyglutamine degeneration.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2008;22(9):3348-57.
2008: Yuk Man Li; H Y Edwin Chan; xiaoqiang yao; Yu Huang; Zhen-Yu Chen
Green tea catechins and broccoli reduce fat-induced mortality in Drosophila melanogaster.
The Journal of nutritional biochemistry 2008;19(6):376-83.
2007: Hau Yi Leung; Yun Wang; H Y Edwin Chan; Lai K Leung
Developing a high-throughput system for the screening of cytochrome P450 1A1--inhibitory polyphenols.
Toxicology in vitro : an international journal published in association with BIBRA 2007;21(6):996-1002.
2007: Yuk Man Li; H Y Edwin Chan; Yu Huang; Zhen-Yu Chen
Green tea catechins upregulate superoxide dismutase and catalase in fruit flies.
Molecular nutrition & food research 2007;51(5):546-54.
2007: Chak-Ming Chan; Cheuk-Wing Ma; Wood Yee Chan; H Y Edwin Chan
The SARS-Coronavirus Membrane protein induces apoptosis through modulating the Akt survival pathway.
Archives of biochemistry and biophysics 2007;459(2):197-207.
2007: N Y Macy Huen; S L Alan Wong; H Y Edwin Chan
Transcriptional malfunctioning of heat shock protein gene expression in spinocerebellar ataxias.
Cerebellum (London, England) 2007;6(2):111-7.
2006: Zheng Xu; So Fun Chau; Kwok Ho Lam; H Y Edwin Chan; Tzi Bun Ng; Shannon W N Au
Crystal structure of the SENP1 mutant C603S-SUMO complex reveals the hydrolytic mechanism of SUMO-specific protease.
The Biochemical journal 2006;398(3):345-52.
2006: Katy Wing-Kam Chau; Wood Yee Chan; Pang-Chui Shaw; H Y Edwin Chan
Biochemical investigation of Tau protein phosphorylation status and its solubility properties in Drosophila.
Biochemical and biophysical research communications 2006;346(1):150-9.
2006: C-P Benny Yiu; Rebecca L Beavil; H Y Edwin Chan
Biophysical characterisation reveals structural disorder in the nucleolar protein, Dribble.
Biochemical and biophysical research communications 2006;343(1):311-8.
2005: S L Alan Wong; Yiwei Chen; Chak Ming Chan; C S Michael Chan; Paul K S Chan; Y L Chui; Kwok-Pui Fung; Mary Waye; Stephen Kwok-Wing Tsui; H Y Edwin Chan
In vivo functional characterization of the SARS-Coronavirus 3a protein in Drosophila.
Biochemical and biophysical research communications 2005;337(2):720-9.
2005: N Y Macy Huen; H Y Edwin Chan
Dynamic regulation of molecular chaperone gene expression in polyglutamine disease.
Biochemical and biophysical research communications 2005;334(4):1074-84.
2005: Patrick T W Law; CHI HANG WONG; Thomas C C Au; Chi-Pang Chuck; Siu-Kai Kong; Paul K S Chan; Ka-Fai To; Anthony W I Lo; Judy Y W Chan; Yick-Keung Suen; H Y Edwin Chan; Kwok-Pui Fung; Mary Waye; Joseph J Y Sung; Y M Dennis Lo; Stephen Kwok-Wing Tsui
The 3a protein of severe acute respiratory syndrome-associated coronavirus induces apoptosis in Vero E6 cells.
The Journal of general virology 2005;86(Pt 7):1921-30.
2003: H Y Edwin Chan; Lai K Leung
A potential protective mechanism of soya isoflavones against 7,12-dimethylbenz[a]anthracene tumour initiation.
The British journal of nutrition 2003;90(2):457-65.
2003: H Y Edwin Chan; Huan Wang; Lai K Leung
The red clover (Trifolium pratense) isoflavone biochanin A modulates the biotransformation pathways of 7,12-dimethylbenz[a]anthracene.
The British journal of nutrition 2003;90(1):87-92.
2003: Ayumi Kusano; Cynthia Staber; H Y Edwin Chan; Barry Ganetzky
Closing the (Ran)GAP on segregation distortion in Drosophila.
BioEssays : news and reviews in molecular, cellular and developmental biology 2003;25(2):108-15.
2003: H Y Edwin Chan; Huan Wang; David S C Tsang; Zhen-Yu Chen; Lai K Leung
Screening of chemopreventive tea polyphenols against PAH genotoxicity in breast cancer cells by a XRE-luciferase reporter construct.
Nutrition and cancer 2003;46(1):93-100.
2003: H Y Edwin Chan; Nancy M Bonini
Drosophila models of polyglutamine diseases.
Methods in molecular biology (Clifton, N.J.) 2003;217():241-51.
2002: H Y Edwin Chan; John M Warrick; Isabella Andriola; Diane E Merry; Nancy M Bonini
Genetic modulation of polyglutamine toxicity by protein conjugation pathways in Drosophila.
Human molecular genetics 2002;11(23):2895-904.
2002: H Y Edwin Chan; Christine K C Tung; Cahir J O'Kane
Rev-GFP transgenic lines for studies of nucleocytoplasmic transport in Drosophila.
Genesis (New York, N.Y. : 2000) 2002;34(1-2):139-41.
2002: H Y Edwin Chan; Zhen-Yu Chen; David S C Tsang; Lai K Leung
Baicalein inhibits DMBA-DNA adduct formation by modulating CYP1A1 and CYP1B1 activities.
Biomedicine & pharmacotherapy = Biomédecine & pharmacothérapie 2002;56(6):269-75.
2002: H Y Edwin Chan
Fly-ing from genes to drugs.
Trends in molecular medicine 2002;8(3):99-101.
2002: Pavan K Auluck; H Y Edwin Chan; John Q Trojanowski; Virginia M-Y Lee; Nancy M Bonini
Chaperone suppression of alpha-synuclein toxicity in a Drosophila model for Parkinson's disease.
Science (New York, N.Y.) 2002;295(5556):865-8.
2001: H Y Edwin Chan; S Brogna; Cahir J O'Kane
Dribble, the Drosophila KRR1p homologue, is involved in rRNA processing.
Molecular biology of the cell 2001;12(5):1409-19.
2000: H Y Edwin Chan; John M Warrick; GL Gray-Board; Henry L Paulson; Nancy M Bonini
Mechanisms of chaperone suppression of polyglutamine disease: selectivity, synergy and modulation of protein solubility in Drosophila.
Human molecular genetics 2000;9(19):2811-20.
2000: S Collier; H Y Edwin Chan; T Toda; Carol McKimmie; Glynnis Johnson; Paul N Adler; Cahir J O'Kane; Michael Ashburner
The Drosophila embargoed gene is required for larval progression and encodes the functional homolog of schizosaccharomyces Crm1.
Genetics 2000;155(4):1799-807.
1999: John M Warrick; H Y Edwin Chan; GL Gray-Board; Y Chai; Henry L Paulson; Nancy M Bonini
Suppression of polyglutamine-mediated neurodegeneration in Drosophila by the molecular chaperone HSP70.
Nature genetics 1999;23(4):425-8.
1998: H Y Edwin Chan; Y Zhang; J D Hoheisel; Cahir J O'Kane
Identification and characterization of the gene for Drosophila L3 ribosomal protein.
Gene 1998;212(1):119-25.
1997: H Y Edwin Chan; Y Zhang; Cahir J O'Kane
Identification and characterization of the gene for Drosophila S20 ribosomal protein.
Gene 1997;200(1-2):85-9.