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Laval Chan

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Bichitra K Biswal; Meitian Wang; Maia M Cherney; Laval Chan; Constantin G Yannopoulos; Darius Bilimoria; Jean Bedard; Michael N G James
Non-nucleoside inhibitors binding to hepatitis C virus NS5B polymerase reveal a novel mechanism of inhibition.
Bichitra K Biswal; Maia M Cherney; Meitian Wang; Laval Chan; Constantin G Yannopoulos; Darius Bilimoria; Olivier Nicolas; Jean Bedard; Michael N G James
Crystal structures of the RNA-dependent RNA polymerase genotype 2a of hepatitis C virus reveal two conformations and suggest mechanisms of inhibition by non-nucleoside inhibitors.
Guy Falardeau; Hugo Lachance; Annie St-Pierre; Constantin G Yannopoulos; Marc Drouin; Jean Bédard; Laval Chan
Design and synthesis of a potent macrocyclic 1,6-naphthyridine anti-human cytomegalovirus (HCMV) inhibitors.

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All Publications

2006: Bichitra K Biswal; Meitian Wang; Maia M Cherney; Laval Chan; Constantin G Yannopoulos; Darius Bilimoria; Jean Bedard; Michael N G James
Non-nucleoside inhibitors binding to hepatitis C virus NS5B polymerase reveal a novel mechanism of inhibition.
Journal of molecular biology 2006;361(1):33-45.
2005: Bichitra K Biswal; Maia M Cherney; Meitian Wang; Laval Chan; Constantin G Yannopoulos; Darius Bilimoria; Olivier Nicolas; Jean Bedard; Michael N G James
Crystal structures of the RNA-dependent RNA polymerase genotype 2a of hepatitis C virus reveal two conformations and suggest mechanisms of inhibition by non-nucleoside inhibitors.
The Journal of biological chemistry 2005;280(18):18202-10.
2005: Guy Falardeau; Hugo Lachance; Annie St-Pierre; Constantin G Yannopoulos; Marc Drouin; Jean Bédard; Laval Chan
Design and synthesis of a potent macrocyclic 1,6-naphthyridine anti-human cytomegalovirus (HCMV) inhibitors.
Bioorganic & medicinal chemistry letters 2005;15(6):1693-5.
2004: Constantin G Yannopoulos; Ping Xu; Feng Ni; Laval Chan; Oswy Pereira; T Jagadeeswar Reddy; Sanjoy K Das; Carl Poisson; Nghe Nguyen-Ba; Nathalie Turcotte; Mélanie Proulx; Lilianne Halab; Wuyi Wang; Jean Bédard; Nicolas Morin; Martine Hamel; Olivier Nicolas; Darius Bilimoria; Lucille L'Heureux; Richard Bethell; Gervais Dionne
HCV NS5B polymerase-bound conformation of a soluble sulfonamide inhibitor by 2D transferred NOESY.
Bioorganic & medicinal chemistry letters 2004;14(21):5333-7.
2004: Laval Chan; Oswy Pereira; T Jagadeeswar Reddy; Sanjoy K Das; Carl Poisson; Marc Courchesne; Mélanie Proulx; Arshad Siddiqui; Constantin G Yannopoulos; Nghe Nguyen-Ba; Caroline Roy; Daniel Nasturica; Christophe Moinet; Richard Bethell; Martine Hamel; Lucille L'Heureux; Maud David; Olivier Nicolas; Philippe Courtemanche-Asselin; Stéphanie Brunette; Darius Bilimoria; Jean Bédard
Discovery of thiophene-2-carboxylic acids as potent inhibitors of HCV NS5B polymerase and HCV subgenomic RNA replication. Part 2: tertiary amides.
Bioorganic & medicinal chemistry letters 2004;14(3):797-800.
2004: Laval Chan; Sanjoy K Das; T Jagadeeswar Reddy; Carl Poisson; Mélanie Proulx; Oswy Pereira; Marc Courchesne; Caroline Roy; Wuyi Wang; Arshad Siddiqui; Constantin G Yannopoulos; Nghe Nguyen-Ba; Denis Labrecque; Richard Bethell; Martine Hamel; Philippe Courtemanche-Asselin; Lucille L'Heureux; Maud David; Olivier Nicolas; Stéphanie Brunette; Darius Bilimoria; Jean Bédard
Discovery of thiophene-2-carboxylic acids as potent inhibitors of HCV NS5B polymerase and HCV subgenomic RNA replication. Part 1: Sulfonamides.
Bioorganic & medicinal chemistry letters 2004;14(3):793-6.
2003: T Jagadeeswar Reddy; Laval Chan; Nathalie Turcotte; Mélanie Proulx; Oswy Pereira; Sanjoy K Das; Arshad Siddiqui; Wuyi Wang; Carl Poisson; Constantin G Yannopoulos; Darius Bilimoria; Lucille L'Heureux; Hicham M A Alaoui; Nghe Nguyen-Ba
Further SAR studies on novel small molecule inhibitors of the hepatitis C (HCV) NS5B polymerase.
Bioorganic & medicinal chemistry letters 2003;13(19):3341-4.
2003: Laval Chan; T Jagadeeswar Reddy; Mélanie Proulx; Sanjoy K Das; Oswy Pereira; Wuyi Wang; Arshad Siddiqui; Constantin G Yannopoulos; Carl Poisson; Nathalie Turcotte; Alexandre Drouin; Moulay H Alaoui-Ismaili; Richard Bethell; Martine Hamel; Lucille L'Heureux; Darius Bilimoria; Nghe Nguyen-Ba
Identification of N,N-disubstituted phenylalanines as a novel class of inhibitors of hepatitis C NS5B polymerase.
Journal of medicinal chemistry 2003;46(8):1283-5.
2003: Meitian Wang; Kenneth K-S Ng; Maia M Cherney; Laval Chan; Constantin G Yannopoulos; Jean Bedard; Nicolas Morin; Nghe Nguyen-Ba; Moulay H Alaoui-Ismaili; Richard Bethell; Michael N G James
Non-nucleoside analogue inhibitors bind to an allosteric site on HCV NS5B polymerase. Crystal structures and mechanism of inhibition.
The Journal of biological chemistry 2003;278(11):9489-95.
2003: Monica Bubenik; Karen Meerovitch; Frédéric Bergeron; Giorgio Attardo; Laval Chan
Thiophene-based vitronectin receptor antagonists.
Bioorganic & medicinal chemistry letters 2003;13(3):503-6.
2003: Karen Meerovitch; Frédéric Bergeron; Lorraine Leblond; Brigitte Grouix; Cathy Poirier; Monica Bubenik; Laval Chan; Henriette Gourdeau; Terry Bowlin; Giorgio Attardo
A novel RGD antagonist that targets both alphavbeta3 and alpha5beta1 induces apoptosis of angiogenic endothelial cells on type I collagen.
Vascular pharmacology 2003;40(2):77-89.
2002: Monica Bubenik; Rabindra Rej; Nghe Nguyen-Ba; Giorgio Attardo; France Ouellet; Laval Chan
Novel nucleotide phosphonate analogues with potent antitumor activity.
Bioorganic & medicinal chemistry letters 2002;12(21):3063-6.
2001: Laval Chan; T Stefanac; JF Lavallée; H Jin; Jean Bédard; S May; Guy Falardeau
Design and synthesis of new potent human cytomegalovirus (HCMV) inhibitors based on internally hydrogen-bonded 1,6-naphthyridines.
Bioorganic & medicinal chemistry letters 2001;11(2):103-5.
2000: Guy Falardeau; Laval Chan; T Stefanac; S May; H Jin; JF Lavallée
Substituted 1,6-naphthyridines as human cytomegalovirus inhibitors: conformational requirements.
Bioorganic & medicinal chemistry letters 2000;10(24):2769-70.
2000: Laval Chan; T Stefanac; Nathalie Turcotte; Z Hu; Y Chen; Jean Bédard; S May; H Jin
Design and evaluation of dihydroisoquinolines as potent and orally bioavailable human cytomegalovirus inhibitors.
Bioorganic & medicinal chemistry letters 2000;10(13):1477-80.
2000: J Bedard; S May; Lucille L'Heureux; T Stamminger; A Copsey; J Drach; J Huffman; Laval Chan; H Jin; RF Rando
Antiviral properties of a series of 1,6-naphthyridine and 7, 8-dihydroisoquinoline derivatives exhibiting potent activity against human cytomegalovirus.
Antimicrobial agents and chemotherapy 2000;44(4):929-37.
1999: Laval Chan; H Jin; T Stefanac; Wuyi Wang; JF Lavallée; Jean Bédard; S May
Isoquinoline-6-carboxamides as potent and selective anti-human cytomegalovirus (HCMV) inhibitors.
Bioorganic & medicinal chemistry letters 1999;9(17):2583-6.
1999: Laval Chan; H Jin; T Stefanac; JF Lavallée; Guy Falardeau; Wuyi Wang; Jean Bédard; S May; L Yuen
Discovery of 1,6-naphthyridines as a novel class of potent and selective human cytomegalovirus inhibitors.
Journal of medicinal chemistry 1999;42(16):3023-5.
1999: Nghe Nguyen-Ba; Laval Chan; M Quimpère; Nathalie Turcotte; N Lee; H Mitchell; Jean Bédard
Design and SAR study of a novel class of nucleotide analogues as potent anti-HCMV agents.
Nucleosides & nucleotides 1999;18(4-5):821-7.
1999: J Bedard; S May; M Lis; L Tryphonas; J Drach; J Huffman; R Sidwell; Laval Chan; Terry Bowlin; RF Rando
Comparative study of the anti-human cytomegalovirus activities and toxicities of a tetrahydrofuran phosphonate analogue of guanosine and cidofovir.
Antimicrobial agents and chemotherapy 1999;43(3):557-67.
1998: P Nguyen-Ba; Nathalie Turcotte; L Yuen; Jean Bédard; M Quimpère; Laval Chan
Identification of novel nucleotide phosphonate analogs with potent anti-HCMV activity.
Bioorganic & medicinal chemistry letters 1998;8(24):3561-6.
1998: P Nguyen-Ba; N Lee; H Mitchell; Laval Chan; M Quimpère
Design and synthesis of a novel class of nucleotide analogs with anti-HCMV activity.
Bioorganic & medicinal chemistry letters 1998;8(24):3555-60.