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Pak Chan

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

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Co-Publications
Name
26
Fujimura, Miki
24
Sugawara, Taku
22
Copin, Jean-Christophe
21
Morita-Fujimura, Yuiko
20
Epstein, Charles
19
Hayashi, Takeshi
18
Kinouchi, Hiroyuki
18
Noshita, Nobuo
17
Saito, Atsushi
16
Koistinaho, Jari
15
Narasimhan, Purnima
15
yu, fengshan
14
Lewén, Anders
14
Sharp, Frank
14
Kamii, Hideyuki

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Publications

TOP 3
Brennan Angela M; Suh Sang Won; Won Seok Joon; Narasimhan Purnima; Kauppinen Tiina M; Lee Hokyou; Edling Ylva; Chan Pak H; Swanson Raymond A
NADPH oxidase is the primary source of superoxide induced by NMDA receptor activation.
Xu Yan; Liachenko Serguei M; Tang Pei; Chan Pak H
Faster recovery of cerebral perfusion in SOD1-overexpressed rats after cardiac arrest and resuscitation.
Chen Hai; Song Yun Seon; Chan Pak H
Inhibition of NADPH oxidase is neuroprotective after ischemia-reperfusion.

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All Publications

2009: Brennan Angela M; Suh Sang Won; Won Seok Joon; Narasimhan Purnima; Kauppinen Tiina M; Lee Hokyou; Edling Ylva; Chan Pak H; Swanson Raymond A
NADPH oxidase is the primary source of superoxide induced by NMDA receptor activation.
Nature neuroscience 2009;12(7):857-63.
2009: Xu Yan; Liachenko Serguei M; Tang Pei; Chan Pak H
Faster recovery of cerebral perfusion in SOD1-overexpressed rats after cardiac arrest and resuscitation.
Stroke; a journal of cerebral circulation 2009;40(7):2512-8.
2009: Chen Hai; Song Yun Seon; Chan Pak H
Inhibition of NADPH oxidase is neuroprotective after ischemia-reperfusion.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2009;29(7):1262-72.
2009: Jung Joo Eun; Kim Gab Seok; Narasimhan Purnima; Song Yun Seon; Chan Pak H
Regulation of Mn-superoxide dismutase activity and neuroprotection by STAT3 in mice after cerebral ischemia.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2009;29(21):7003-14.
2009: Niizuma Kuniyasu; Endo Hidenori; Chan Pak H
Oxidative stress and mitochondrial dysfunction as determinants of ischemic neuronal death and survival.
Journal of neurochemistry 2009;109 Suppl 1():133-8.
2009: Narasimhan Purnima; Liu Jing; Song Yun Seon; Massengale Justin L; Chan Pak H
VEGF Stimulates the ERK 1/2 signaling pathway and apoptosis in cerebral endothelial cells after ischemic conditions.
Stroke; a journal of cerebral circulation 2009;40(4):1467-73.
2009: Niizuma Kuniyasu; Endo Hidenori; Nito Chikako; Myer D Jeannie; Chan Pak H
Potential role of PUMA in delayed death of hippocampal CA1 neurons after transient global cerebral ischemia.
Stroke; a journal of cerebral circulation 2009;40(2):618-25.
2008: Song Yun Seon; Narasimhan Purnima; Kim Gab Seok; Jung Joo Eun; Park Eun-Hee; Chan Pak H
The role of Akt signaling in oxidative stress mediates NF-kappaB activation in mild transient focal cerebral ischemia.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2008;28(12):1917-26.
2008: Niizuma Kuniyasu; Endo Hidenori; Nito Chikako; Myer D Jeannie; Kim Gab Seok; Chan Pak H
The PIDDosome mediates delayed death of hippocampal CA1 neurons after transient global cerebral ischemia in rats.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(42):16368-73.
2008: Nito Chikako; Kamada Hiroshi; Endo Hidenori; Niizuma Kuniyasu; Myer D Jeannie; Chan Pak H
Role of the p38 mitogen-activated protein kinase/cytosolic phospholipase A2 signaling pathway in blood-brain barrier disruption after focal cerebral ischemia and reperfusion.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2008;28(10):1686-96.
2008: Suh Sang Won; Hamby Aaron M; Gum Elizabeth T; Shin Byung Seop; Won Seok Joon; Sheline Christian T; Chan Pak H; Swanson Raymond A
Sequential release of nitric oxide, zinc, and superoxide in hypoglycemic neuronal death.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2008;28(10):1697-706.
2008: Copin Jean-Christophe; Merlani Paolo; Sugawara Taku; Chan Pak H; Gasche Yvan
Delayed matrix metalloproteinase inhibition reduces intracerebral hemorrhage after embolic stroke in rats.
Experimental neurology 2008;213(1):196-201.
2008: Yu Fengshan; Kamada Hiroshi; Niizuma Kuniyasu; Endo Hidenori; Chan Pak H
Induction of mmp-9 expression and endothelial injury by oxidative stress after spinal cord injury.
Journal of neurotrauma 2008;25(3):184-95.
2008: Goldsteins Gundars; Keksa-Goldsteine Velta; Ahtoniemi Toni; Jaronen Merja; Arens Egils; Akerman Karl; Chan Pak H; Koistinaho Jari
Deleterious role of superoxide dismutase in the mitochondrial intermembrane space.
The Journal of biological chemistry 2008;283(13):8446-52.
2008: Yu Fengshan; Narasimhan Purnima; Saito Atsushi; Liu Jing; Chan Pak H
Increased expression of a proline-rich Akt substrate (PRAS40) in human copper/zinc-superoxide dismutase transgenic rats protects motor neurons from death after spinal cord injury.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2008;28(1):44-52.
2007: Endo Hidenori; Nito Chikako; Kamada Hiroshi; Yu Fengshan; Chan Pak H
Reduction in oxidative stress by superoxide dismutase overexpression attenuates acute brain injury after subarachnoid hemorrhage via activation of Akt/glycogen synthase kinase-3beta survival signaling.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2007;27(5):975-82.
2007: Suh Sang Won; Gum Elizabeth T; Hamby Aaron M; Chan Pak H; Swanson Raymond A
Hypoglycemic neuronal death is triggered by glucose reperfusion and activation of neuronal NADPH oxidase.
The Journal of clinical investigation 2007;117(4):910-8.
2007: Song Yun Seon; Lee Yong-Sun; Narasimhan Purnima; Chan Pak H
Reduced oxidative stress promotes NF-kappaB-mediated neuroprotective gene expression after transient focal cerebral ischemia: lymphocytotrophic cytokines and antiapoptotic factors.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2007;27(4):764-75.
2007: Kamada Hiroshi; Yu Fengshan; Nito Chikako; Chan Pak H
Influence of hyperglycemia on oxidative stress and matrix metalloproteinase-9 activation after focal cerebral ischemia/reperfusion in rats: relation to blood-brain barrier dysfunction.
Stroke; a journal of cerebral circulation 2007;38(3):1044-9.
2007: Kamada Hiroshi; Nito Chikako; Endo Hidenori; Chan Pak H
Bad as a converging signaling molecule between survival PI3-K/Akt and death JNK in neurons after transient focal cerebral ischemia in rats.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2007;27(3):521-33.
2006: Maier C M; Hsieh L; Crandall T; Narasimhan P; Chan P H
A new approach for the investigation of reperfusion-related brain injury.
Biochemical Society transactions 2006;34(Pt 6):1366-9.
2006: Endo H; Saito A; Chan P H
Mitochondrial translocation of p53 underlies the selective death of hippocampal CA1 neurons after global cerebral ischaemia.
Biochemical Society transactions 2006;34(Pt 6):1283-6.
2006: Endo Hidenori; Nito Chikako; Kamada Hiroshi; Nishi Tatsuro; Chan Pak H
Activation of the Akt/GSK3beta signaling pathway mediates survival of vulnerable hippocampal neurons after transient global cerebral ischemia in rats.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2006;26(12):1479-89.
2006: Endo Hidenori; Nito Chikako; Kamada Hiroshi; Yu Fengshan; Chan Pak H
Akt/GSK3beta survival signaling is involved in acute brain injury after subarachnoid hemorrhage in rats.
Stroke; a journal of cerebral circulation 2006;37(8):2140-6.
2006: Lee Yong-Sun; Song Yun Seon; Giffard Rona G; Chan Pak H
Biphasic role of nuclear factor-kappa B on cell survival and COX-2 expression in SOD1 Tg astrocytes after oxygen glucose deprivation.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2006;26(8):1076-88.
2006: Endo Hidenori; Kamada Hiroshi; Nito Chikako; Nishi Tatsuro; Chan Pak H
Mitochondrial translocation of p53 mediates release of cytochrome c and hippocampal CA1 neuronal death after transient global cerebral ischemia in rats.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2006;26(30):7974-83.
2006: Maier Carolina M; Hsieh Lily; Crandall Trisha; Narasimhan Purnima; Chan Pak H
Evaluating therapeutic targets for reperfusion-related brain hemorrhage.
Annals of neurology 2006;59(6):929-38.
2006: Yu Fengshan; Sugawara Taku; Nishi Tatsuro; Liu Jing; Chan Pak H
Overexpression of SOD1 in transgenic rats attenuates nuclear translocation of endonuclease G and apoptosis after spinal cord injury.
Journal of neurotrauma 2006;23(5):595-603.
2006: Koyama Shingo; Arawaka Shigeki; Chang-Hong Ren; Wada Manabu; Kawanami Toru; Kurita Keiji; Kato Masaaki; Nagai Makiko; Aoki Masashi; Itoyama Yasuto; Sobue Gen; Chan Pak H; Kato Takeo
Alteration of familial ALS-linked mutant SOD1 solubility with disease progression: its modulation by the proteasome and Hsp70.
Biochemical and biophysical research communications 2006;343(3):719-30.
2006: Liu Jing; Narasimhan Purnima; Lee Yong-Sun; Song Yun Seon; Endo Hidenori; Yu Fengshan; Chan Pak H
Mild hypoxia promotes survival and proliferation of SOD2-deficient astrocytes via c-Myc activation.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2006;26(16):4329-37.
2006: Maier Carolina M; Yu Fengshan; Nishi Tatsuro; Lathrop Stephanie J; Chan Pak H
Interferon-beta fails to protect in a model of transient focal stroke.
Stroke; a journal of cerebral circulation 2006;37(4):1116-9.
2006: Liu Jing; Narasimhan Purnima; Song Yun Seon; Nishi Tatsuro; Yu Fengshan; Lee Yong-Sun; Chan Pak H
Epo protects SOD2-deficient mouse astrocytes from damage by oxidative stress.
Glia 2006;53(4):360-5.
2006: Saito Atsushi; Hayashi Takeshi; Okuno Shuzo; Nishi Tatsuro; Chan Pak H
Modulation of proline-rich akt substrate survival signaling pathways by oxidative stress in mouse brains after transient focal cerebral ischemia.
Stroke; a journal of cerebral circulation 2006;37(2):513-7.
2005: Lee Byung I; Chan Pak H; Kim Gyung W
Metalloporphyrin-based superoxide dismutase mimic attenuates the nuclear translocation of apoptosis-inducing factor and the subsequent DNA fragmentation after permanent focal cerebral ischemia in mice.
Stroke; a journal of cerebral circulation 2005;36(12):2712-7.
2005: Yu Fengshan; Sugawara Taku; Maier Carolina M; Hsieh Lily B; Chan Pak H
Akt/Bad signaling and motor neuron survival after spinal cord injury.
Neurobiology of disease 2005;20(2):491-9.
2005: Song Yun S; Lee Yong-Sun; Chan Pak H
Oxidative stress transiently decreases the IKK complex (IKKalpha, beta, and gamma), an upstream component of NF-kappaB signaling, after transient focal cerebral ischemia in mice.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2005;25(10):1301-11.
2005: Nishi Tatsuro; Maier Carolina M; Hayashi Takeshi; Saito Atsushi; Chan Pak H
Superoxide dismutase 1 overexpression reduces MCP-1 and MIP-1 alpha expression after transient focal cerebral ischemia.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2005;25(10):1312-24.
2005: Gidday Jeffrey M; Gasche Yvan G; Copin Jean-C; Shah Aarti R; Perez Ronald S; Shapiro Steven D; Chan Pak H; Park T S
Leukocyte-derived matrix metalloproteinase-9 mediates blood-brain barrier breakdown and is proinflammatory after transient focal cerebral ischemia.
American journal of physiology. Heart and circulatory physiology 2005;289(2):H558-68.
2005: Saito Atsushi; Tominaga Teiji; Chan Pak H
Neuroprotective role of neurotrophins: relationship between nerve growth factor and apoptotic cell survival pathway after cerebral ischemia.
Current atherosclerosis reports 2005;7(4):268-73.
2005: Li Feng; Hayashi Takeshi; Jin Guang; Deguchi Kentaro; Nagotani Shoko; Nagano Isao; Shoji Mikio; Chan Pak H; Abe Koji
The protective effect of dantrolene on ischemic neuronal cell death is associated with reduced expression of endoplasmic reticulum stress markers.
Brain research 2005;1048(1-2):59-68.
2005: Liu Jing; Narasimhan Purnima; Yu Fengshan; Chan Pak H
Neuroprotection by hypoxic preconditioning involves oxidative stress-mediated expression of hypoxia-inducible factor and erythropoietin.
Stroke; a journal of cerebral circulation 2005;36(6):1264-9.
2005: Chan Pak H
Mitochondrial dysfunction and oxidative stress as determinants of cell death/survival in stroke.
Annals of the New York Academy of Sciences 2005;1042():203-9.
2005: Narasimhan Purnima; Sugawara Taku; Liu Jing; Hayashi Takeshi; Noshita Nobuo; Chan Pak H
Overexpression of human copper/zinc-superoxide dismutase in transgenic animals attenuates the reduction of apurinic/apyrimidinic endonuclease expression in neurons after in vitro ischemia and after transient global cerebral ischemia.
Journal of neurochemistry 2005;93(2):351-8.
2005: Saito Atsushi; Hayashi Takeshi; Okuno Shuzo; Nishi Tatsuro; Chan Pak H
Modulation of p53 degradation via MDM2-mediated ubiquitylation and the ubiquitin-proteasome system during reperfusion after stroke: role of oxidative stress.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2005;25(2):267-80.
2005: Hayashi Takeshi; Saito Atsushi; Okuno Shuzo; Ferrand-Drake Michel; Dodd Robert L; Chan Pak H
Damage to the endoplasmic reticulum and activation of apoptotic machinery by oxidative stress in ischemic neurons.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2005;25(1):41-53.
2005: Fujimura Miki; Tominaga Teiji; Chan Pak H
Neuroprotective effect of an antioxidant in ischemic brain injury: involvement of neuronal apoptosis.
Neurocritical care 2005;2(1):59-66.
2005: Saito Atsushi; Maier Carolina M; Narasimhan Purnima; Nishi Tatsuro; Song Yun Seon; Yu Fengshan; Liu Jing; Lee Yong-Sun; Nito Chikako; Kamada Hiroshi; Dodd Robert L; Hsieh Lily B; Hassid Benjamin; Kim Esther E; González Maricela; Chan Pak H
Oxidative stress and neuronal death/survival signaling in cerebral ischemia.
Molecular neurobiology 2005;31(1-3):105-16.
2004: Chan Pak H
Mitochondria and neuronal death/survival signaling pathways in cerebral ischemia.
Neurochemical research 2004;29(11):1943-9.
2004: Saito Atsushi; Hayashi Takeshi; Okuno Shuzo; Nishi Tatsuro; Chan Pak H
Oxidative stress affects the integrin-linked kinase signaling pathway after transient focal cerebral ischemia.
Stroke; a journal of cerebral circulation 2004;35(11):2560-5.
2004: Chan Pak H
Future targets and cascades for neuroprotective strategies.
Stroke; a journal of cerebral circulation 2004;35(11 Suppl 1):2748-50.
2004: Okuno Shuzo; Saito Atsushi; Hayashi Takeshi; Chan Pak H
The c-Jun N-terminal protein kinase signaling pathway mediates Bax activation and subsequent neuronal apoptosis through interaction with Bim after transient focal cerebral ischemia.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2004;24(36):7879-87.
2004: Saito Atsushi; Hayashi Takeshi; Okuno Shuzo; Nishi Tatsuro; Chan Pak H
Modulation of the Omi/HtrA2 signaling pathway after transient focal cerebral ischemia in mouse brains that overexpress SOD1.
Brain research. Molecular brain research 2004;127(1-2):89-95.
2004: Paschen Wulf; Hayashi Takeshi; Saito Atsushi; Chan Pak H
GADD34 protein levels increase after transient ischemia in the cortex but not in the CA1 subfield: implications for post-ischemic recovery of protein synthesis in ischemia-resistant cells.
Journal of neurochemistry 2004;90(3):694-701.
2004: Saito Atsushi; Hayashi Takeshi; Okuno Shuzo; Nishi Tatsuro; Chan Pak H
Oxidative stress is associated with XIAP and Smac/DIABLO signaling pathways in mouse brains after transient focal cerebral ischemia.
Stroke; a journal of cerebral circulation 2004;35(6):1443-8.
2004: Maier Carolina M; Hsieh Lily; Yu Fengshan; Bracci Paige; Chan Pak H
Matrix metalloproteinase-9 and myeloperoxidase expression: quantitative analysis by antigen immunohistochemistry in a model of transient focal cerebral ischemia.
Stroke; a journal of cerebral circulation 2004;35(5):1169-74.
2004: Hirai Kiyoshi; Hayashi Takeshi; Chan Pak H; Zeng Jianying; Yang Guo-Yuan; Basus Vladimir J; James Thomas L; Litt Lawrence
PI3K inhibition in neonatal rat brain slices during and after hypoxia reduces phospho-Akt and increases cytosolic cytochrome c and apoptosis.
Brain research. Molecular brain research 2004;124(1):51-61.
2004: Hayashi Takeshi; Saito Atsushi; Okuno Shuzo; Ferrand-Drake Michel; Dodd Robert L; Chan Pak H
Oxidative injury to the endoplasmic reticulum in mouse brains after transient focal ischemia.
Neurobiology of disease 2004;15(2):229-39.
2004: Saito Atsushi; Narasimhan Purnima; Hayashi Takeshi; Okuno Shuzo; Ferrand-Drake Michel; Chan Pak H
Neuroprotective role of a proline-rich Akt substrate in apoptotic neuronal cell death after stroke: relationships with nerve growth factor.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2004;24(7):1584-93.
2004: Sugawara Taku; Fujimura Miki; Noshita Nobuo; Kim Gyung Whan; Saito Atsushi; Hayashi Takeshi; Narasimhan Purnima; Maier Carolina M; Chan Pak H
Neuronal death/survival signaling pathways in cerebral ischemia.
NeuroRx : the journal of the American Society for Experimental NeuroTherapeutics 2004;1(1):17-25.
2003: Sugawara Taku; Chan Pak H
Reactive oxygen radicals and pathogenesis of neuronal death after cerebral ischemia.
Antioxidants & redox signaling 2003;5(5):597-607.
2003: Junge Candice E; Sugawara Taku; Mannaioni Guido; Alagarsamy Sudar; Conn P Jeffrey; Brat Daniel J; Chan Pak H; Traynelis Stephen F
The contribution of protease-activated receptor 1 to neuronal damage caused by transient focal cerebral ischemia.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(22):13019-24.
2003: Hayashi Takeshi; Saito Atsushi; Okuno Shuzo; Ferrand-Drake Michel; Dodd Robert L; Nishi Tatsuro; Maier Carolina M; Kinouchi Hiroyuki; Chan Pak H
Oxidative damage to the endoplasmic reticulum is implicated in ischemic neuronal cell death.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2003;23(10):1117-28.
2003: Kim Gyung W; Gasche Yvan; Grzeschik Susanna; Copin Jean-Christophe; Maier Carolina M; Chan Pak H
Neurodegeneration in striatum induced by the mitochondrial toxin 3-nitropropionic acid: role of matrix metalloproteinase-9 in early blood-brain barrier disruption?
The Journal of neuroscience : the official journal of the Society for Neuroscience 2003;23(25):8733-42.
2003: Saito Atsushi; Hayashi Takeshi; Okuno Shuzo; Ferrand-Drake Michel; Chan Pak H
Interaction between XIAP and Smac/DIABLO in the mouse brain after transient focal cerebral ischemia.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2003;23(9):1010-9.
2003: Hayashi Takeshi; Saito Atsushi; Okuno Shuzo; Ferrand-Drake Michel; Chan Pak H
Induction of GRP78 by ischemic preconditioning reduces endoplasmic reticulum stress and prevents delayed neuronal cell death.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2003;23(8):949-61.
2003: Koponen Susanna; Kurkinen Kaisa; Akerman Karl E O; Mochly-Rosen Daria; Chan Pak H; Koistinaho Jari
Prevention of NMDA-induced death of cortical neurons by inhibition of protein kinase Czeta.
Journal of neurochemistry 2003;86(2):442-50.
2003: Yu Fengshan; Sugawara Taku; Chan Pak H
Treatment with dihydroethidium reduces infarct size after transient focal cerebral ischemia in mice.
Brain research 2003;978(1-2):223-7.
2003: Grzeschik Susanna M; Maier Carolina M; Chan Pak H
Effects of cold injury-induced trauma in manganese superoxide dismutase-deficient mice.
Journal of neurotrauma 2003;20(6):571-81.
2003: Ferrand-Drake Michel; Zhu Changlian; Gidö Gunilla; Hansen Anker J; Karlsson Jan-Olof; Bahr Ben A; Zamzami Naoufal; Kroemer Guido; Chan Pak H; Wieloch Tadeusz; Blomgren Klas
Cyclosporin A prevents calpain activation despite increased intracellular calcium concentrations, as well as translocation of apoptosis-inducing factor, cytochrome c and caspase-3 activation in neurons exposed to transient hypoglycemia.
Journal of neurochemistry 2003;85(6):1431-42.
2003: Noshita Nobuo; Sugawara Taku; Lewén Anders; Hayashi Takeshi; Chan Pak H
Copper-zinc superoxide dismutase affects Akt activation after transient focal cerebral ischemia in mice.
Stroke; a journal of cerebral circulation 2003;34(6):1513-8.
2003: Narasimhan Purnima; Fujimura Miki; Noshita Nobuo; Chan Pak H
Role of superoxide in poly(ADP-ribose) polymerase upregulation after transient cerebral ischemia.
Brain research. Molecular brain research 2003;113(1-2):28-36.
2003: Saito Atsushi; Hayashi Takeshi; Okuno Shuzo; Ferrand-Drake Michel; Chan Pak H
Overexpression of copper/zinc superoxide dismutase in transgenic mice protects against neuronal cell death after transient focal ischemia by blocking activation of the Bad cell death signaling pathway.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2003;23(5):1710-8.
2003: Vartiainen Nina; Goldsteins Gundars; Keksa-Goldsteine Velta; Chan Pak H; Koistinaho Jari
Aspirin inhibits p44/42 mitogen-activated protein kinase and is protective against hypoxia/reoxygenation neuronal damage.
Stroke; a journal of cerebral circulation 2003;34(3):752-7.
2003: Hayashi Takeshi; Noshita Nobuo; Sugawara Taku; Chan Pak H
Temporal profile of angiogenesis and expression of related genes in the brain after ischemia.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2003;23(2):166-80.
2003: Klein Matthew B; Chan Pak H; Chang James
Protective effects of superoxide dismutase against ischemia-reperfusion injury: development and application of a transgenic animal model.
Plastic and reconstructive surgery 2003;111(1):251-5; discussion 256-7.
2003: Wang Xinkang; Wang Hugh; Xu Lin; Rozanski Dennis J; Sugawara Taku; Chan Pak H; Trzaskos James M; Feuerstein Giora Z
Significant neuroprotection against ischemic brain injury by inhibition of the MEK1 protein kinase in mice: exploration of potential mechanism associated with apoptosis.
The Journal of pharmacology and experimental therapeutics 2003;304(1):172-8.
2003: Hirai K; Hayashi T; Chan P H; Basus V J; James T L; Litt L
Akt phosphorylation and cell survival after hypoxia-induced cytochrome c release in superfused respiring neonatal rat cerebrocortical slices.
Acta neurochirurgica. Supplement 2003;86():227-30.
2002: Sugawara Taku; Lewén Anders; Gasche Yvan; Yu Fengshan; Chan Pak H
Overexpression of SOD1 protects vulnerable motor neurons after spinal cord injury by attenuating mitochondrial cytochrome c release.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2002;16(14):1997-9.
2002: Yang Jun; Klaidman Lori K; Nalbandian Artak; Oliver Jasmine; Chang Mei L; Chan Pak H; Adams James D
The effects of nicotinamide on energy metabolism following transient focal cerebral ischemia in Wistar rats.
Neuroscience letters 2002;333(2):91-4.
2002: Maier Carolina M; Sun Guo Hua; Cheng Danye; Yenari Midori A; Chan Pak H; Steinberg Gary K
Effects of mild hypothermia on superoxide anion production, superoxide dismutase expression, and activity following transient focal cerebral ischemia.
Neurobiology of disease 2002;11(1):28-42.
2002: Hirai Kiyoshi; Sugawara Taku; Chan Pak H; Basus Vladimir J; James Thomas L; Litt Lawrence
Cytochrome c associated apoptosis during ATP recovery after hypoxia in neonatal rat cerebrocortical slices.
Journal of neurochemistry 2002;83(2):309-19.
2002: Noshita Nobuo; Sugawara Taku; Hayashi Takeshi; Lewén Anders; Omar Ghezal; Chan Pak H
Copper/zinc superoxide dismutase attenuates neuronal cell death by preventing extracellular signal-regulated kinase activation after transient focal cerebral ischemia in mice.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2002;22(18):7923-30.
2002: Maier Carolina M; Chan Pak H
Role of superoxide dismutases in oxidative damage and neurodegenerative disorders.
The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry 2002;8(4):323-34.
2002: Kokubo Yasuaki; Matson Gerald B; Derugin Nikita; Hill Tony; Mancuso Anthony; Chan Pak H; Weinstein Philip R
Transgenic mice expressing human copper-zinc superoxide dismutase exhibit attenuated apparent diffusion coefficient reduction during reperfusion following focal cerebral ischemia.
Brain research 2002;947(1):1-8.
2002: Kim Gyung W; Chan Pak H
Involvement of superoxide in excitotoxicity and DNA fragmentation in striatal vulnerability in mice after treatment with the mitochondrial toxin, 3-nitropropionic acid.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2002;22(7):798-809.
2002: Massengale Justin L; Gasche Yvan; Chan Pak H
Carbohydrate source influences gelatinase production by mouse astrocytes in vitro.
Glia 2002;38(3):240-5.
2002: Noshita Nobuo; Lewén Anders; Sugawara Taku; Chan Pak H
Akt phosphorylation and neuronal survival after traumatic brain injury in mice.
Neurobiology of disease 2002;9(3):294-304.
2002: Chang Mei Ling; Yang Jun; Kem Seyha; Klaidman Lori; Sugawara Taku; Chan Pak H; Adams James D
Nicotinamide and ketamine reduce infarct volume and DNA fragmentation in rats after brain ischemia and reperfusion.
Neuroscience letters 2002;322(3):137-40.
2002: Kim Gyung W; Kondo Takeo; Noshita Nobuo; Chan Pak H
Manganese superoxide dismutase deficiency exacerbates cerebral infarction after focal cerebral ischemia/reperfusion in mice: implications for the production and role of superoxide radicals.
Stroke; a journal of cerebral circulation 2002;33(3):809-15.
2002: Sugawara Taku; Lewén Anders; Noshita Nobuo; Gasche Yvan; Chan Pak H
Effects of global ischemia duration on neuronal, astroglial, oligodendroglial, and microglial reactions in the vulnerable hippocampal CA1 subregion in rats.
Journal of neurotrauma 2002;19(1):85-98.
2002: Yenari Midori A; Iwayama Satoshi; Cheng Danye; Sun Guo Hua; Fujimura Miki; Morita-Fujimura Yuiko; Chan Pak H; Steinberg Gary K
Mild hypothermia attenuates cytochrome c release but does not alter Bcl-2 expression or caspase activation after experimental stroke.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2002;22(1):29-38.
2002: Sugawara Taku; Noshita Nobuo; Lewén Anders; Gasche Yvan; Ferrand-Drake Michel; Fujimura Miki; Morita-Fujimura Yuiko; Chan Pak H
Overexpression of copper/zinc superoxide dismutase in transgenic rats protects vulnerable neurons against ischemic damage by blocking the mitochondrial pathway of caspase activation.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2002;22(1):209-17.
2001: Noshita N; Lewén A; Sugawara T; Chan P H
Evidence of phosphorylation of Akt and neuronal survival after transient focal cerebral ischemia in mice.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2001;21(12):1442-50.
2001: Gasche Y; Copin J C; Sugawara T; Fujimura M; Chan P H
Matrix metalloproteinase inhibition prevents oxidative stress-associated blood-brain barrier disruption after transient focal cerebral ischemia.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2001;21(12):1393-400.
2001: Sugawara T; Yu F; Ma L; Hsia C J; Chan P H
Delayed treatment with polynitroxyl albumin reduces infarct size after stroke in rats.
Neuroreport 2001;12(16):3609-12.
2001: Sugawara T; Noshita N; Lewén A; Kim G W; Chan P H
Neuronal expression of the DNA repair protein Ku 70 after ischemic preconditioning corresponds to tolerance to global cerebral ischemia.
Stroke; a journal of cerebral circulation 2001;32(10):2388-93.
2001: Morita-Fujimura Y; Fujimura M; Yoshimoto T; Chan P H
Superoxide during reperfusion contributes to caspase-8 expression and apoptosis after transient focal stroke.
Stroke; a journal of cerebral circulation 2001;32(10):2356-61.
2001: Matz P G; Lewén A; Chan P H
Neuronal, but not microglial, accumulation of extravasated serum proteins after intracerebral hemolysate exposure is accompanied by cytochrome c release and DNA fragmentation.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2001;21(8):921-8.
2001: Lewén A; Fujimura M; Sugawara T; Matz P; Copin J C; Chan P H
Oxidative stress-dependent release of mitochondrial cytochrome c after traumatic brain injury.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2001;21(8):914-20.
2001: Saito A; Kamii H; Kato I; Takasawa S; Kondo T; Chan P H; Okamoto H; Yoshimoto T
Transgenic CuZn-superoxide dismutase inhibits NO synthase induction in experimental subarachnoid hemorrhage.
Stroke; a journal of cerebral circulation 2001;32(7):1652-7.
2001: Lewén A; Sugawara T; Gasche Y; Fujimura M; Chan P H
Oxidative cellular damage and the reduction of APE/Ref-1 expression after experimental traumatic brain injury.
Neurobiology of disease 2001;8(3):380-90.
2001: Chen Y; Vartiainen N E; Ying W; Chan P H; Koistinaho J; Swanson R A
Astrocytes protect neurons from nitric oxide toxicity by a glutathione-dependent mechanism.
Journal of neurochemistry 2001;77(6):1601-10.
2001: Kim G W; Noshita N; Sugawara T; Chan P H
Early decrease in dna repair proteins, Ku70 and Ku86, and subsequent DNA fragmentation after transient focal cerebral ischemia in mice.
Stroke; a journal of cerebral circulation 2001;32(6):1401-7.
2001: Noshita N; Sugawara T; Fujimura M; Morita-Fujimura Y; Chan P H
Manganese Superoxide Dismutase Affects Cytochrome c Release and Caspase-9 Activation After Transient Focal Cerebral Ischemia in Mice.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2001;21(5):557-67.
2001: Chen Y; Chan P H; Swanson R A
Astrocytes overexpressing Cu,Zn superoxide dismutase have increased resistance to oxidative injury.
Glia 2001;33(4):343-7.
2001: Huang C Y; Fujimura M; Chang Y Y; Chan P H
Overexpression of copper-zinc superoxide dismutase attenuates acute activation of activator protein-1 after transient focal cerebral ischemia in mice.
Stroke; a journal of cerebral circulation 2001;32(3):741-7.
2001: Huang C Y; Fujimura M; Noshita N; Chang Y Y; Chan P H
SOD1 down-regulates NF-kappaB and c-Myc expression in mice after transient focal cerebral ischemia.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2001;21(2):163-73.
2001: Kim G W; Chan P H
Oxidative stress and neuronal DNA fragmentation mediate age-dependent vulnerability to the mitochondrial toxin, 3-nitropropionic acid, in the mouse striatum.
Neurobiology of disease 2001;8(1):114-26.
2001: Matz P G; Fujimura M; Lewen A; Morita-Fujimura Y; Chan P H
Increased cytochrome c-mediated DNA fragmentation and cell death in manganese-superoxide dismutase-deficient mice after exposure to subarachnoid hemolysate.
Stroke; a journal of cerebral circulation 2001;32(2):506-15.
2001: Copin J C; Gasche Y; Li Y; Chan P H
Prolonged hypoxia during cell development protects mature manganese superoxide dismutase-deficient astrocytes from damage by oxidative stress.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2001;15(2):525-34.
2001: Gobbel G T; Chan P H
Neuronal death is an active, caspase-dependent process after moderate but not severe DNA damage.
Journal of neurochemistry 2001;76(2):520-31.
2001: Vartiainen N; Huang C Y; Salminen A; Goldsteins G; Chan P H; Koistinaho J
Piroxicam and NS-398 rescue neurones from hypoxia/reoxygenation damage by a mechanism independent of cyclo-oxygenase inhibition.
Journal of neurochemistry 2001;76(2):480-9.
2001: Fujimura M; Morita-Fujimura Y; Copin J; Yoshimoto T; Chan P H
Reduction of copper, zinc-superoxide dismutase in knockout mice does not affect edema or infarction volumes and the early release of mitochondrial cytochrome c after permanent focal cerebral ischemia.
Brain research 2001;889(1-2):208-13.
2001: Chan P H
Reactive oxygen radicals in signaling and damage in the ischemic brain.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2001;21(1):2-14.
2001: Kim G W; Lewén A; Copin J; Watson B D; Chan P H
The cytosolic antioxidant, copper/zinc superoxide dismutase, attenuates blood-brain barrier disruption and oxidative cellular injury after photothrombotic cortical ischemia in mice.
Neuroscience 2001;105(4):1007-18.
2000: Kim G W; Sugawara T; Chan P H
Involvement of oxidative stress and caspase-3 in cortical infarction after photothrombotic ischemia in mice.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2000;20(12):1690-701.
2000: Lewén A; Matz P; Chan P H
Free radical pathways in CNS injury.
Journal of neurotrauma 2000;17(10):871-90.
2000: Matz P G; Copin J C; Chan P H
Cell death after exposure to subarachnoid hemolysate correlates inversely with expression of CuZn-superoxide dismutase.
Stroke; a journal of cerebral circulation 2000;31(10):2450-9.
2000: Sugawara T; Kawase M; Lewén A; Noshita N; Gasche Y; Fujimura M; Chan P H
Effect of hypotension severity on hippocampal CA1 neurons in a rat global ischemia model.
Brain research 2000;877(2):281-7.
2000: Chen Y; Ying W; Simma V; Copin J C; Chan P H; Swanson R A
Overexpression of Cu,Zn superoxide dismutase attenuates oxidative inhibition of astrocyte glutamate uptake.
Journal of neurochemistry 2000;75(3):939-45.
2000: Yrjänheikki J; Koistinaho J; Copin J C; de Crespigny A; Moseley M E; Chan P H
Spreading depression-induced expression of c-fos and cyclooxygenase-2 in transgenic mice that overexpress human copper/zinc-superoxide dismutase.
Journal of neurotrauma 2000;17(8):713-8.
2000: Fujimura M; Morita-Fujimura Y; Noshita N; Yoshimoto T; Chan P H
Reduction of the DNA base excision repair protein, XRCC1, may contribute to DNA fragmentation after cold injury-induced brain trauma in mice.
Brain research 2000;869(1-2):105-11.
2000: Koistinaho J; Chan P H
Spreading depression-induced cyclooxygenase-2 expression in the cortex.
Neurochemical research 2000;25(5):645-51.
2000: Fujimura M; Morita-Fujimura Y; Noshita N; Sugawara T; Kawase M; Chan P H
The cytosolic antioxidant copper/zinc-superoxide dismutase prevents the early release of mitochondrial cytochrome c in ischemic brain after transient focal cerebral ischemia in mice.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2000;20(8):2817-24.
2000: Matz P G; Fujimura M; Chan P H
Subarachnoid hemolysate produces DNA fragmentation in a pattern similar to apoptosis in mouse brain.
Brain research 2000;858(2):312-9.
2000: Ying W; Anderson C M; Chen Y; Stein B A; Fahlman C S; Copin J C; Chan P H; Swanson R A
Differing effects of copper,zinc superoxide dismutase overexpression on neurotoxicity elicited by nitric oxide, reactive oxygen species, and excitotoxins.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2000;20(2):359-68.
2000: Morita-Fujimura Y; Fujimura M; Gasche Y; Copin J C; Chan P H
Overexpression of copper and zinc superoxide dismutase in transgenic mice prevents the induction and activation of matrix metalloproteinases after cold injury-induced brain trauma.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2000;20(1):130-8.
2000: Kim G W; Copin J C; Kawase M; Chen S F; Sato S; Gobbel G T; Chan P H
Excitotoxicity is required for induction of oxidative stress and apoptosis in mouse striatum by the mitochondrial toxin, 3-nitropropionic acid.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2000;20(1):119-29.
1999: Chang Y Y; Fujimura M; Morita-Fujimura Y; Kim G W; Huang C Y; Wu H S; Kawase M; Copin J C; Chan P H
Neuroprotective effects of an antioxidant in cortical cerebral ischemia: prevention of early reduction of the apurinic/apyrimidinic endonuclease DNA repair enzyme.
Neuroscience letters 1999;277(1):61-4.
1999: Yrjänheikki J; Tikka T; Keinänen R; Goldsteins G; Chan P H; Koistinaho J
A tetracycline derivative, minocycline, reduces inflammation and protects against focal cerebral ischemia with a wide therapeutic window.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(23):13496-500.
1999: Fujimura M; Morita-Fujimura Y; Sugawara T; Chan P H
Early decrease of XRCC1, a DNA base excision repair protein, may contribute to DNA fragmentation after transient focal cerebral ischemia in mice.
Stroke; a journal of cerebral circulation 1999;30(11):2456-62; discussion 2463.
1999: Fujimura M; Morita-Fujimura Y; Narasimhan P; Copin J C; Kawase M; Chan P H
Copper-zinc superoxide dismutase prevents the early decrease of apurinic/apyrimidinic endonuclease and subsequent DNA fragmentation after transient focal cerebral ischemia in mice.
Stroke; a journal of cerebral circulation 1999;30(11):2408-15.
1999: Fujimura M; Gasche Y; Morita-Fujimura Y; Massengale J; Kawase M; Chan P H
Early appearance of activated matrix metalloproteinase-9 and blood-brain barrier disruption in mice after focal cerebral ischemia and reperfusion.
Brain research 1999;842(1):92-100.
1999: Gasche Y; Fujimura M; Morita-Fujimura Y; Copin J C; Kawase M; Massengale J; Chan P H
Early appearance of activated matrix metalloproteinase-9 after focal cerebral ischemia in mice: a possible role in blood-brain barrier dysfunction.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 1999;19(9):1020-8.
1999: Kawase M; Murakami K; Fujimura M; Morita-Fujimura Y; Gasche Y; Kondo T; Scott R W; Chan P H
Exacerbation of delayed cell injury after transient global ischemia in mutant mice with CuZn superoxide dismutase deficiency.
Stroke; a journal of cerebral circulation 1999;30(9):1962-8.
1999: Koistinaho J; Koponen S; Chan P H
Expression of cyclooxygenase-2 mRNA after global ischemia is regulated by AMPA receptors and glucocorticoids.
Stroke; a journal of cerebral circulation 1999;30(9):1900-5; discussion 1905-6.
1999: Li Y; Carlson E; Murakami K; Copin J C; Luche R; Chen S F; Epstein C J; Chan P H
Targeted expression of human CuZn superoxide dismutase gene in mouse central nervous system.
Journal of neuroscience methods 1999;89(1):49-55.
1999: Morita-Fujimura Y; Fujimura M; Kawase M; Chen S F; Chan P H
Release of mitochondrial cytochrome c and DNA fragmentation after cold injury-induced brain trauma in mice: possible role in neuronal apoptosis.
Neuroscience letters 1999;267(3):201-5.
1999: Morita-Fujimura Y; Fujimura M; Kawase M; Murakami K; Kim G W; Chan P H
Inhibition of interleukin-1beta converting enzyme family proteases (caspases) reduces cold injury-induced brain trauma and DNA fragmentation in mice.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 1999;19(6):634-42.
1999: Fujimura M; Morita-Fujimura Y; Kawase M; Chan P H
Early decrease of apurinic/apyrimidinic endonuclease expression after transient focal cerebral ischemia in mice.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 1999;19(5):495-501.
1999: Litt L; Espanol M T; Hasegawa K; Chang L H; Gregory G A; James T L; Beal M F; Chan P H
NOS inhibitors decrease hypoxia-induced ATP reductions in respiring cerebrocortical slices.
Anesthesiology 1999;90(5):1392-401.
1999: Fujimura M; Morita-Fujimura Y; Kawase M; Copin J C; Calagui B; Epstein C J; Chan P H
Manganese superoxide dismutase mediates the early release of mitochondrial cytochrome C and subsequent DNA fragmentation after permanent focal cerebral ischemia in mice.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1999;19(9):3414-22.
1999: Kamii H; Kato I; Kinouchi H; Chan P H; Epstein C J; Akabane A; Okamoto H; Yoshimoto T
Amelioration of vasospasm after subarachnoid hemorrhage in transgenic mice overexpressing CuZn-superoxide dismutase.
Stroke; a journal of cerebral circulation 1999;30(4):867-71; discussion 872.
1999: Murakami K; Kondo T; Yang G; Chen S F; Morita-Fujimura Y; Chan P H
Cold injury in mice: a model to study mechanisms of brain edema and neuronal apoptosis.
Progress in neurobiology 1999;57(3):289-99.
1999: Koistinaho J; Pasonen S; Yrjänheikki J; Chan P H
Spreading depression-induced gene expression is regulated by plasma glucose.
Stroke; a journal of cerebral circulation 1999;30(1):114-9.
1999: Morita-Fujimura Y; Fujimura M; Kawase M; Chan P H
Early decrease in apurinic/apyrimidinic endonuclease is followed by DNA fragmentation after cold injury-induced brain trauma in mice.
Neuroscience 1999;93(4):1465-73.
1999: Vartiainen N; Tikka T; Keinänen R; Chan P H; Koistinaho J
Glutamatergic receptors regulate expression, phosphorylation and accumulation of neurofilaments in spinal cord neurons.
Neuroscience 1999;93(3):1123-33.
1999: Koponen S; Keinänen R; Roivainen R; Hirvonen T; Närhi M; Chan P H; Koistinaho J
Spreading depression induces expression of calcium-independent protein kinase C subspecies in ischaemia-sensitive cortical layers: regulation by N-methyl-D-aspartate receptors and glucocorticoids.
Neuroscience 1999;93(3):985-93.
1998: Kinouchi H; Kamii H; Mikawa S; Epstein C J; Yoshimoto T; Chan P H
Role of superoxide dismutase in ischemic brain injury: a study using SOD-1 transgenic mice.
Cellular and molecular neurobiology 1998;18(6):609-20.
1998: Li Y; Copin J C; Reola L F; Calagui B; Gobbel G T; Chen S F; Sato S; Epstein C J; Chan P H
Reduced mitochondrial manganese-superoxide dismutase activity exacerbates glutamate toxicity in cultured mouse cortical neurons.
Brain research 1998;814(1-2):164-70.
1998: Fujimura M; Morita-Fujimura Y; Murakami K; Kawase M; Chan P H
Cytosolic redistribution of cytochrome c after transient focal cerebral ischemia in rats.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 1998;18(11):1239-47.
1998: Murakami K; Kawase M; Kondo T; Chan P H
Cellular accumulation of extravasated serum protein and DNA fragmentation following vasogenic edema.
Journal of neurotrauma 1998;15(10):825-35.
1998: Sato S; Gobbel G T; Honkaniemi J; Li Y; Kondo T; Murakami K; Sato M; Copin J C; Sharp F R; Chan P H
Decreased expression of bcl-2 and bcl-x mRNA coincides with apoptosis following intracerebral administration of 3-nitropropionic acid.
Brain research 1998;808(1):56-64.
1998: Chan P H; Kawase M; Murakami K; Chen S F; Li Y; Calagui B; Reola L; Carlson E; Epstein C J
Overexpression of SOD1 in transgenic rats protects vulnerable neurons against ischemic damage after global cerebral ischemia and reperfusion.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1998;18(20):8292-9.
1998: Fullerton H J; Ditelberg J S; Chen S F; Sarco D P; Chan P H; Epstein C J; Ferriero D M
Copper/zinc superoxide dismutase transgenic brain accumulates hydrogen peroxide after perinatal hypoxia ischemia.
Annals of neurology 1998;44(3):357-64.
1998: Li Y; Chan P H
Identification of the pro-oncogene stathmin/op18 mRNA in the brain of mitochondrial Mn-superoxide dismutase-deficient mice by a modified differential display PCR.
Brain research. Molecular brain research 1998;55(2):277-84.
1998: Hasegawa K; Litt L; Espanol M T; Sharp F R; Chan P H
Expression of c-fos and hsp70 mRNA in neonatal rat cerebrocortical slices during NMDA-induced necrosis and apoptosis.
Brain research 1998;785(2):262-78.
1998: Copin J C; Li Y; Reola L; Chan P H
Trolox and 6,7-dinitroquinoxaline-2,3-dione prevent necrosis but not apoptosis in cultured neurons subjected to oxygen deprivation.
Brain research 1998;784(1-2):25-36.
1998: Espanol M T; Litt L; Hasegawa K; Chang L H; Macdonald J M; Gregory G; James T L; Chan P H
Fructose-1,6-bisphosphate preserves adenosine triphosphate but not intracellular pH during hypoxia in respiring neonatal rat brain slices.
Anesthesiology 1998;88(2):461-72.
1998: Murakami K; Kondo T; Kawase M; Chan P H
The development of a new mouse model of global ischemia: focus on the relationships between ischemia duration, anesthesia, cerebral vasculature, and neuronal injury following global ischemia in mice.
Brain research 1998;780(2):304-10.
1998: Murakami K; Kondo T; Kawase M; Li Y; Sato S; Chen S F; Chan P H
Mitochondrial susceptibility to oxidative stress exacerbates cerebral infarction that follows permanent focal cerebral ischemia in mutant mice with manganese superoxide dismutase deficiency.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1998;18(1):205-13.
1998: Gobbel G T; Bellinzona M; Vogt A R; Gupta N; Fike J R; Chan P H
Response of postmitotic neurons to X-irradiation: implications for the role of DNA damage in neuronal apoptosis.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1998;18(1):147-55.
1997: Murakami K; Kondo T; Sato S; Li Y; Chan P H
Occurrence of apoptosis following cold injury-induced brain edema in mice.
Neuroscience 1997;81(1):231-7.
1997: Gobbel G T; Chan T Y; Chan P H
Nitric oxide- and superoxide-mediated toxicity in cerebral endothelial cells.
The Journal of pharmacology and experimental therapeutics 1997;282(3):1600-7.
1997: Murakami K; Kondo T; Epstein C J; Chan P H
Overexpression of CuZn-superoxide dismutase reduces hippocampal injury after global ischemia in transgenic mice.
Stroke; a journal of cerebral circulation 1997;28(9):1797-804.
1997: Huang T T; Yasunami M; Carlson E J; Gillespie A M; Reaume A G; Hoffman E K; Chan P H; Scott R W; Epstein C J
Superoxide-mediated cytotoxicity in superoxide dismutase-deficient fetal fibroblasts.
Archives of biochemistry and biophysics 1997;344(2):424-32.
1997: Kondo T; Reaume A G; Huang T T; Carlson E; Murakami K; Chen S F; Hoffman E K; Scott R W; Epstein C J; Chan P H
Reduction of CuZn-superoxide dismutase activity exacerbates neuronal cell injury and edema formation after transient focal cerebral ischemia.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1997;17(11):4180-9.
1997: Kondo T; Sharp F R; Honkaniemi J; Mikawa S; Epstein C J; Chan P H
DNA fragmentation and Prolonged expression of c-fos, c-jun, and hsp70 in kainic acid-induced neuronal cell death in transgenic mice overexpressing human CuZn-superoxide dismutase.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 1997;17(3):241-56.
1997: Murakami K; Kondo T; Chan P H
Reperfusion following focal cerebral ischemia alters distribution of neuronal cells with DNA fragmentation in mice.
Brain research 1997;751(1):160-4.
1997: Hasegawa K; Litt L; Espanol M T; Gregory G A; Sharp F R; Chan P H
Effects of neuroprotective dose of fructose-1,6-bisphosphate on hypoxia-induced expression of c-fos and hsp70 mRNA in neonatal rat cerebrocortical slices.
Brain research 1997;750(1-2):1-10.
1997: Sato S; Gobbel G T; Honkaniemi J; Li Y; Kondo T; Murakami K; Sato M; Copin J C; Chan P H
Apoptosis in the striatum of rats following intraperitoneal injection of 3-nitropropionic acid.
Brain research 1997;745(1-2):343-7.
1997: Sato S; Gobbel G T; Li Y; Kondo T; Murakami K; Sato M; Hasegawa K; Copin J C; Honkaniemi J; Sharp F R; Chan P H
Blood-brain barrier disruption, HSP70 expression and apoptosis due to 3-nitropropionic acid, a mitochondrial toxin.
Acta neurochirurgica. Supplement 1997;70():237-9.
1997: Murakami K; Kondo T; Chan P H
Blood-brain barrier disruption, edema formation, and apoptotic neuronal death following cold injury.
Acta neurochirurgica. Supplement 1997;70():234-6.
1997: Kondo T; Reaume A G; Huang T T; Murakami K; Carlson E; Chen S; Scott R W; Epstein C J; Chan P H
Edema formation exacerbates neurological and histological outcomes after focal cerebral ischemia in CuZn-superoxide dismutase gene knockout mutant mice.
Acta neurochirurgica. Supplement 1997;70():62-4.
1996: Kamii H; Mikawa S; Murakami K; Kinouchi H; Yoshimoto T; Reola L; Carlson E; Epstein C J; Chan P H
Effects of nitric oxide synthase inhibition on brain infarction in SOD-1-transgenic mice following transient focal cerebral ischemia.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 1996;16(6):1153-7.
1996: Mikawa S; Kinouchi H; Kamii H; Gobbel G T; Chen S F; Carlson E; Epstein C J; Chan P H
Attenuation of acute and chronic damage following traumatic brain injury in copper, zinc-superoxide dismutase transgenic mice.
Journal of neurosurgery 1996;85(5):885-91.
1996: Kondo T; Murakami K; Honkaniemi J; Sharp F R; Epstein C J; Chan P H
Expression of hsp70 mRNA is induced in the brain of transgenic mice overexpressing human CuZn-superoxide dismutase following transient global cerebral ischemia.
Brain research 1996;737(1-2):321-6.
1996: Imaizumi S; Kondo T; Deli M A; Gobbel G; Joó F; Epstein C J; Yoshimoto T; Chan P H
The influence of oxygen free radicals on the permeability of the monolayer of cultured brain endothelial cells.
Neurochemistry international 1996;29(2):205-11.
1996: Kelleher J A; Chan T Y; Chan P H; Gregory G A
Protection of astrocytes by fructose 1,6-bisphosphate and citrate ameliorates neuronal injury under hypoxic conditions.
Brain research 1996;726(1-2):167-73.
1996: Chan P H
Role of oxidants in ischemic brain damage.
Stroke; a journal of cerebral circulation 1996;27(6):1124-9.
1996: Longuemare M C; Keung E C; Chun S; Sharp F R; Chan P H; Swanson R A
MK-801 reduces uptake and stimulates efflux of excitatory amino acids via membrane depolarization.
The American journal of physiology 1996;270(5 Pt 1):C1398-404.
1996: Copin J C; Reola L F; Chan T Y; Li Y; Epstein C J; Chan P H
Oxygen deprivation but not a combination of oxygen, glucose, and serum deprivation induces DNA degradation in mouse cortical neurons in vitro: attenuation by transgenic overexpression of CuZn-superoxide dismutase.
Journal of neurotrauma 1996;13(5):233-44.
1996: Espanol M T; Litt L; Chang L H; James T L; Weinstein P R; Chan P H
Adult rat brain-slice preparation for nuclear magnetic resonance spectroscopy studies of hypoxia.
Anesthesiology 1996;84(1):201-10.
1996: Chan P H; Epstein C J; Kinouchi H; Kamii H; Chen S F; Carlson E; Gafni J; Yang G; Reola L
Neuroprotective role of CuZn-superoxide dismutase in ischemic brain damage.
Advances in neurology 1996;71():271-280.
1995: Li Y; Huang T T; Carlson E J; Melov S; Ursell P C; Olson J L; Noble L J; Yoshimura M P; Berger C; Chan P H; Wallace D C; Epstein C J
Dilated cardiomyopathy and neonatal lethality in mutant mice lacking manganese superoxide dismutase.
Nature genetics 1995;11(4):376-81.
1995: Chan P H; Epstein C J; Li Y; Huang T T; Carlson E; Kinouchi H; Yang G; Kamii H; Mikawa S; Kondo T
Transgenic mice and knockout mutants in the study of oxidative stress in brain injury.
Journal of neurotrauma 1995;12(5):815-24.
1995: Kelleher J A; Chan P H; Chan T Y; Gregory G A
Energy metabolism in hypoxic astrocytes: protective mechanism of fructose-1,6-bisphosphate.
Neurochemical research 1995;20(7):785-92.
1995: Gobbel G T; Chan T Y; Chan P H
Amelioration of hypoxic and hypoglycemic damage to cerebral endothelial cells. Effects of heat shock pretreatment.
Molecular and chemical neuropathology / sponsored by the International Society for Neurochemistry and the World Federation of Neurology and research groups on neurochemistry and cerebrospinal fluid 1995;24(2-3):107-20.
1995: Chen J; Graham S H; Chan P H; Lan J; Zhou R L; Simon R P
bcl-2 is expressed in neurons that survive focal ischemia in the rat.
Neuroreport 1995;6(2):394-8.
1994: Kondo T; Imaizumi S; Kato I; Deli M A; Jóo F; Chan P H; Epstein C J; Yoshimoto T
[Effect of free radicals on the permeability of the blood brain barrier--using in vitro blood brain barrier model of human-SOD transgenic mouse]
No to shinkei = Brain and nerve 1994;46(12):1155-61.
1994: Chan P H; Epstein C J; Kinouchi H; Kamii H; Imaizumi S; Yang G; Chen S F; Gafni J; Carlson E
SOD-1 transgenic mice as a model for studies of neuroprotection in stroke and brain trauma.
Annals of the New York Academy of Sciences 1994;738():93-103.
1994: Kamii H; Kinouchi H; Sharp F R; Epstein C J; Sagar S M; Chan P H
Expression of c-fos mRNA after a mild focal cerebral ischemia in SOD-1 transgenic mice.
Brain research 1994;662(1-2):240-4.
1994: Kinouchi H; Sharp F R; Chan P H; Koistinaho J; Sagar S M; Yoshimoto T
Induction of c-fos, junB, c-jun, and hsp70 mRNA in cortex, thalamus, basal ganglia, and hippocampus following middle cerebral artery occlusion.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 1994;14(5):808-17.
1994: Kinouchi H; Sharp F R; Chan P H; Mikawa S; Kamii H; Arai S; Yoshimoto T
MK-801 inhibits the induction of immediate early genes in cerebral cortex, thalamus, and hippocampus, but not in substantia nigra following middle cerebral artery occlusion.
Neuroscience letters 1994;179(1-2):111-4.
1994: Gobbel G T; Chan T Y; Gregory G A; Chan P H
Response of cerebral endothelial cells to hypoxia: modification by fructose-1,6-bisphosphate but not glutamate receptor antagonists.
Brain research 1994;653(1-2):23-30.
1994: Karibe H; Chen S F; Zarow G J; Gafni J; Graham S H; Chan P H; Weinstein P R
Mild intraischemic hypothermia suppresses consumption of endogenous antioxidants after temporary focal ischemia in rats.
Brain research 1994;649(1-2):12-8.
1994: Kamii H; Kinouchi H; Sharp F R; Koistinaho J; Epstein C J; Chan P H
Prolonged expression of hsp70 mRNA following transient focal cerebral ischemia in transgenic mice overexpressing CuZn-superoxide dismutase.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 1994;14(3):478-86.
1994: Espanol M T; Litt L; Xu Y; Chang L H; James T L; Weinstein P R; Chan P H
19F NMR calcium changes, edema and histology in neonatal rat brain slices during glutamate toxicity.
Brain research 1994;647(1):172-6.
1994: Mintorovitch J; Yang G Y; Shimizu H; Kucharczyk J; Chan P H; Weinstein P R
Diffusion-weighted magnetic resonance imaging of acute focal cerebral ischemia: comparison of signal intensity with changes in brain water and Na+,K(+)-ATPase activity.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 1994;14(2):332-6.
1994: Espanol M T; Xu Y; Litt L; Yang G Y; Chang L H; James T L; Weinstein P; Chan P H
Modulation of glutamate-induced intracellular energy failure in neonatal cerebral cortical slices by kynurenic acid, dizocilpine, and NBQX.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 1994;14(2):269-78.
1994: Yang G; Chan P H; Chen S F; Babuna O A; Simon R P; Weinstein P R
Reduction of vasogenic edema and infarction by MK-801 in rats after temporary focal cerebral ischemia.
Neurosurgery 1994;34(2):339-45; discussion 345.
1994: Kelleher J A; Gregory G A; Chan P H
Effect of fructose-1,6-bisphosphate on glutamate uptake and glutamine synthetase activity in hypoxic astrocyte cultures.
Neurochemical research 1994;19(2):209-15.
1994: Yang G; Chan P H; Chen J; Carlson E; Chen S F; Weinstein P; Epstein C J; Kamii H
Human copper-zinc superoxide dismutase transgenic mice are highly resistant to reperfusion injury after focal cerebral ischemia.
Stroke; a journal of cerebral circulation 1994;25(1):165-70.
1994: Imaizumi S; Chang L; Cohen Y; Chan P H; Weinstein P R; Yoshimoto T; James T L
Reduction of superoxide dismutase activity correlates with visualization of edema by T2-weighted MR imaging in focal ischemic rat brain.
Neurologia medico-chirurgica 1994;34(1):1-9.
1994: Espanol M T; Xu Y; Litt L; Chang L H; James T L; Weinstein P R; Chan P H
Modulation of edema by dizocilpine, kynurenate, and NBQX in respiring brain slices after exposure to glutamate.
Acta neurochirurgica. Supplementum 1994;60():58-61.
1993: Chan P H; Kamii H; Yang G; Gafni J; Epstein C J; Carlson E; Reola L
Brain infarction is not reduced in SOD-1 transgenic mice after a permanent focal cerebral ischemia.
Neuroreport 1993;5(3):293-6.
1993: Sharp F R; Kinouchi H; Koistinaho J; Chan P H; Sagar S M
HSP70 heat shock gene regulation during ischemia.
Stroke; a journal of cerebral circulation 1993;24(12 Suppl):I72-5.
1993: Kinouchi H; Sharp F R; Koistinaho J; Hicks K; Kamii H; Chan P H
Induction of heat shock hsp70 mRNA and HSP70 kDa protein in neurons in the 'penumbra' following focal cerebral ischemia in the rat.
Brain research 1993;619(1-2):334-8.
1993: Kelleher J A; Chan P H; Chan T Y; Gregory G A
Modification of hypoxia-induced injury in cultured rat astrocytes by high levels of glucose.
Stroke; a journal of cerebral circulation 1993;24(6):855-63.
1993: Hirose K; Chan P H
Blockade of glutamate excitotoxicity and its clinical applications.
Neurochemical research 1993;18(4):479-83.
1993: Kinouchi H; Sharp F R; Hill M P; Koistinaho J; Sagar S M; Chan P H
Induction of 70-kDa heat shock protein and hsp70 mRNA following transient focal cerebral ischemia in the rat.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 1993;13(1):105-15.
1993: Gutin P H; Levin K J; McDermott M W; Hooper N; Smith M T; Cashman J R; Chan P H; Ross G Y; Phillips T L; Levin V A
Lipid peroxidation does not appear to be a factor in late radiation injury of the cervical spinal cord of rats.
International journal of radiation oncology, biology, physics 1993;25(1):67-72.
1993: Chan P H; Kinouchi H; Epstein C J; Carlson E; Chen S F; Imaizumi S; Yang G Y
Role of superoxide dismutase in ischemic brain injury: reduction of edema and infarction in transgenic mice following focal cerebral ischemia.
Progress in brain research 1993;96():97-104.
1992: Espanol M T; Litt L; Yang G Y; Chang L H; Chan P H; James T L; Weinstein P R
Tolerance of low intracellular pH during hypercapnia by rat cortical brain slices: A 31P/1H NMR study.
Journal of neurochemistry 1992;59(5):1820-8.
1992: Yang G Y; Chen S F; Kinouchi H; Chan P H; Weinstein P R
Edema, cation content, and ATPase activity after middle cerebral artery occlusion in rats.
Stroke; a journal of cerebral circulation 1992;23(9):1331-6.
1992: Chan P H
Antioxidant-dependent amelioration of brain injury: role of CuZn-superoxide dismutase.
Journal of neurotrauma 1992;9 Suppl 2():S417-23.
1992: Mizui T; Kinouchi H; Chan P H
Depletion of brain glutathione by buthionine sulfoximine enhances cerebral ischemic injury in rats.
The American journal of physiology 1992;262(2 Pt 2):H313-7.
1992: Noble L J; Hall J J; Chen S; Chan P H
Morphologic changes in cultured astrocytes after exposure to glutamate.
Journal of neurotrauma 1992;9(3):255-67.
1991: Kinouchi H; Epstein C J; Mizui T; Carlson E; Chen S F; Chan P H
Attenuation of focal cerebral ischemic injury in transgenic mice overexpressing CuZn superoxide dismutase.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(24):11158-62.
1991: Dux E; Noble L; Chan P H
Glutamine stimulates growth in rat cerebral endothelial cell culture.
Journal of neuroscience research 1991;29(3):355-61.
1991: Chan P H; Yang G Y; Chen S F; Carlson E; Epstein C J
Cold-induced brain edema and infarction are reduced in transgenic mice overexpressing CuZn-superoxide dismutase.
Annals of neurology 1991;29(5):482-6.
1990: Chan P H; Chu L; Chen S F; Carlson E J; Epstein C J
Reduced neurotoxicity in transgenic mice overexpressing human copper-zinc-superoxide dismutase.
Stroke; a journal of cerebral circulation 1990;21(11 Suppl):III80-2.
1990: Imaizumi S; Woolworth V; Fishman R A; Chan P H
Liposome-entrapped superoxide dismutase reduces cerebral infarction in cerebral ischemia in rats.
Stroke; a journal of cerebral circulation 1990;21(9):1312-7.
1990: Gregory G A; Welsh F A; Yu A C; Chan P H
Fructose-1,6-bisphosphate reduces ATP loss from hypoxic astrocytes.
Brain research 1990;516(2):310-2.
1990: Chan P H; Chu L; Chen S
Effects of MK-801 on glutamate-induced swelling of astrocytes in primary cell culture.
Journal of neuroscience research 1990;25(1):87-93.
1990: Pereira B M; Chan P H; Weinstein P R; Fishman R A
Cerebral protection during reperfusion with superoxide dismutase in focal cerebral ischemia.
Advances in neurology 1990;52():97-103.
1990: Chan P H; Fishman R A; Wesley M A; Longar S
Pathogenesis of vasogenic edema in focal cerebral ischemia. Role of superoxide radicals.
Advances in neurology 1990;52():177-83.
1990: Epstein C J; Berger C N; Carlson E J; Chan P H; Huang T T
Models for Down syndrome: chromosome 21-specific genes in mice.
Progress in clinical and biological research 1990;360():215-32.
1990: Gutin P H; McDermott M W; Ross G; Chan P H; Chen S F; Levin K J; Babuna O; Marton L J
Polyamine accumulation and vasogenic oedema in the genesis of late delayed radiation injury of the central nervous system (CNS).
Acta neurochirurgica. Supplementum 1990;51():372-4.
1990: Imaizumi S; Woolworth V; Kinouchi H; Chen S F; Fishman R A; Chan P H
Liposome-entrapped superoxide dismutase ameliorates infarct volume in focal cerebral ischaemia.
Acta neurochirurgica. Supplementum 1990;51():236-8.
1990: Chan P H; Chu L
Mechanisms underlying glutamate-induced swelling of astrocytes in primary culture.
Acta neurochirurgica. Supplementum 1990;51():7-10.
1990: Chan P H; Chu L; Chen S F; Carlson E J; Epstein C J
Attenuation of glutamate-induced neuronal swelling and toxicity in transgenic mice overexpressing human CuZn-superoxide dismutase.
Acta neurochirurgica. Supplementum 1990;51():245-7.
1989: Hillered L; Chan P H
Brain mitochondrial swelling induced by arachidonic acid and other long chain free fatty acids.
Journal of neuroscience research 1989;24(2):247-50.
1989: Chan P H; Chu L
Ketamine protects cultured astrocytes from glutamate-induced swelling.
Brain research 1989;487(2):380-3.
1989: Gregory G A; Yu A C; Chan P H
Fructose-1,6-bisphosphate protects astrocytes from hypoxic damage.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 1989;9(1):29-34.
1989: Yu A C; Gregory G A; Chan P H
Hypoxia-induced dysfunctions and injury of astrocytes in primary cell cultures.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 1989;9(1):20-8.
1989: Chan P H; Longar S; Chen S; Yu A C; Hillered L; Chu L; Imaizumi S; Pereira B; Moore K; Woolworth V
The role of arachidonic acid and oxygen radical metabolites in the pathogenesis of vasogenic brain edema and astrocytic swelling.
Annals of the New York Academy of Sciences 1989;559():237-47.
1988: Hillered L; Chan P H
Role of arachidonic acid and other free fatty acids in mitochondrial dysfunction in brain ischemia.
Journal of neuroscience research 1988;20(4):451-6.
1988: Chan P H; Chen S F; Yu A C
Induction of intracellular superoxide radical formation by arachidonic acid and by polyunsaturated fatty acids in primary astrocytic cultures.
Journal of neurochemistry 1988;50(4):1185-93.
1988: Chan P H; Chu L; Fishman R A
Reduction of activities of superoxide dismutase but not of glutathione peroxidase in rat brain regions following decapitation ischemia.
Brain research 1988;439(1-2):388-90.
1988: Hillered L; Chan P H
Effects of arachidonic acid on respiratory activities in isolated brain mitochondria.
Journal of neuroscience research 1988;19(1):94-100.
1987: Chan P H; Longar S; Fishman R A
Protective effects of liposome-entrapped superoxide dismutase on posttraumatic brain edema.
Annals of neurology 1987;21(6):540-7.
1985: Chan P H; Fishman R A; Longar S; Chen S; Yu A
Cellular and molecular effects of polyunsaturated fatty acids in brain ischemia and injury.
Progress in brain research 1985;63():227-35.
1984: Chan P H; Schmidley J W; Fishman R A; Longar S M
Brain injury, edema, and vascular permeability changes induced by oxygen-derived free radicals.
Neurology 1984;34(3):315-20.
1984: Chan P H; Fishman R A; Schmidley J W; Chen S F
Release of polyunsaturated fatty acids from phospholipids and alteration of brain membrane integrity by oxygen-derived free radicals.
Journal of neuroscience research 1984;12(4):595-605.
1983: Chan P H; Longar S; Fishman R A
Phospholipid degradation and edema development in cold-injured rat brain.
Brain research 1983;277(2):329-37.
1983: Chan P H; Fishman R A; Caronna J; Schmidley J W; Prioleau G; Lee J
Induction of brain edema following intracerebral injection of arachidonic acid.
Annals of neurology 1983;13(6):625-32.

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