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Pak Chan

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Jiwon Yang; Hye-Na Ahn; Pak H Chan; Minsun Chang; Purnima Narasimhan; Yun Seon Song
Complement component 3 inhibition by an antioxidant is neuroprotective after cerebral ischemia and reperfusion in mice.
Nobuya Okami; Hiroyuki Sakata; Hideyuki Yoshioka; Joo Eun Jung; Gab Seok Kim; Carolina M Maier; Purnima Narasimhan; Pak H Chan
Prevention of JNK phosphorylation as a mechanism for rosiglitazone in neuroprotection after transient cerebral ischemia: activation of dual specificity phosphatase.
Hiroyuki Sakata; Takuma Wakai; Carolina M Maier; Purnima Narasimhan; Kuniyasu Niizuma; Pak H Chan
Interleukin 6-preconditioned neural stem cells reduce ischaemic injury in stroke mice.

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2013: Jiwon Yang; Hye-Na Ahn; Pak H Chan; Minsun Chang; Purnima Narasimhan; Yun Seon Song
Complement component 3 inhibition by an antioxidant is neuroprotective after cerebral ischemia and reperfusion in mice.
Journal of neurochemistry 2013;124(4):523-35.
2013: Nobuya Okami; Hiroyuki Sakata; Hideyuki Yoshioka; Joo Eun Jung; Gab Seok Kim; Carolina M Maier; Purnima Narasimhan; Pak H Chan
Prevention of JNK phosphorylation as a mechanism for rosiglitazone in neuroprotection after transient cerebral ischemia: activation of dual specificity phosphatase.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2013;33(1):106-14.
2012: Hiroyuki Sakata; Takuma Wakai; Carolina M Maier; Purnima Narasimhan; Kuniyasu Niizuma; Pak H Chan
Interleukin 6-preconditioned neural stem cells reduce ischaemic injury in stroke mice.
Brain : a journal of neurology 2012;135(Pt 11):3298-310.
2012: Chikako Nito; Hidenori Endo; Hiroshi Kamada; Yong-Sun Lee; Purnima Narasimhan; Pak H Chan
Involvement of mitogen-activated protein kinase pathways in expression of the water channel protein aquaporin-4 after ischemia in rat cortical astrocytes.
Journal of neurotrauma 2012;29(14):2404-12.
2012: Hiroyuki Sakata; Takuma Wakai; Carolina M Maier; Purnima Narasimhan; Kuniyasu Niizuma; Pak H Chan
Neural stem cells genetically modified to overexpress cu/zn-superoxide dismutase enhance amelioration of ischemic stroke in mice.
Stroke; a journal of cerebral circulation 2012;43(9):2423-9.
2012: Gab Seok Kim; Purnima Narasimhan; Hiroyuki Sakata; Joo Eun Jung; Pak H Chan
Induction of thioredoxin-interacting protein is mediated by oxidative stress, calcium, and glucose after brain injury in mice.
Neurobiology of disease 2012;46(2):440-9.
2012: Gab Seok Kim; Purnima Narasimhan; Nobuya Okami; Hiroyuki Sakata; Yun Seon Song; Hideyuki Yoshioka; Joo Eun Jung; Pak H Chan
Release of mitochondrial apoptogenic factors and cell death are mediated by CK2 and NADPH oxidase.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2012;32(4):720-30.
2012: Hiroyuki Sakata; Hideyuki Yoshioka; Joo Eun Jung; Masataka Katsu; Gab Seok Kim; Carolina M Maier; Purnima Narasimhan; Kuniyasu Niizuma; Yasuhiro Nishiyama; Pak H Chan
Minocycline-preconditioned neural stem cells enhance neuroprotection after ischemic stroke in rats.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2012;32(10):3462-73.
2012: Nicolas Foin; Ryo Torii; Giuseppe Nicola Viceconte; Eduardo Alegria-Barrero; Pak H Chan; Justin E Davies; Carlo Di Mario
Crush, culotte, T and protrusion: which 2-stent technique for treatment of true bifurcation lesions? - insights from in vitro experiments and micro-computed tomography.
Circulation journal : official journal of the Japanese Circulation Society 2012;77(1):73-80.
2011: Joo Eun Jung; Gab Seok Kim; Pak H Chan
Neuroprotection by interleukin-6 is mediated by signal transducer and activator of transcription 3 and antioxidative signaling in ischemic stroke.
Stroke; a journal of cerebral circulation 2011;42(12):3574-9.
2011: S Veiga; J C Bresnahan; Pak H Chan; J Ly; M S Beattie
SOD1 overexpression improves features of the oligodendrocyte precursor response in vitro.
Neuroscience letters 2011;503(1):10-4.
2011: Nicolas Foin; Rob Krams; Alistair C Lindsay; Giuseppe Nicola Viceconte; Pak H Chan; Carlo Di Mario
Jailed side branches: fate of unapposed struts studied with 3D frequency-domain optical coherence tomography.
Journal of cardiovascular medicine (Hagerstown, Md.) 2011;12(8):581-2.
2011: Hai Chen; Gab Seok Kim; Nobuya Okami; Purnima Narasimhan; Pak H Chan
NADPH oxidase is involved in post-ischemic brain inflammation.
Neurobiology of disease 2011;42(3):341-8.
2011: Hai Chen; Hideyuki Yoshioka; Gab Seok Kim; Joo Eun Jung; Nobuya Okami; Hiroyuki Sakata; Carolina M Maier; Purnima Narasimhan; Christina E Goeders; Pak H Chan
Oxidative stress in ischemic brain damage: mechanisms of cell death and potential molecular targets for neuroprotection.
Antioxidants & redox signaling 2011;14(8):1505-17.
2011: Hideyuki Yoshioka; Kuniyasu Niizuma; Masataka Katsu; Hiroyuki Sakata; Nobuya Okami; Pak H Chan
Consistent injury to medium spiny neurons and white matter in the mouse striatum after prolonged transient global cerebral ischemia.
Journal of neurotrauma 2011;28(4):649-60.
2011: Hideyuki Yoshioka; Kuniyasu Niizuma; Masataka Katsu; Nobuya Okami; Hiroyuki Sakata; Gab Seok Kim; Purnima Narasimhan; Pak H Chan
NADPH oxidase mediates striatal neuronal injury after transient global cerebral ischemia.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2011;31(3):868-80.
2010: Masataka Katsu; Kuniyasu Niizuma; Hideyuki Yoshioka; Nobuya Okami; Hiroyuki Sakata; Pak H Chan
Hemoglobin-induced oxidative stress contributes to matrix metalloproteinase activation and blood-brain barrier dysfunction in vivo.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2010;30(12):1939-50.
2010: Yun Seon Song; Min-Soo Kim; Hyun-Ae Kim; Bo-In Jung; Jiwon Yang; Purnima Narasimhan; Gab Seok Kim; Joo Eun Jung; Eun-Hee Park; Pak H Chan
Oxidative stress increases phosphorylation of IkappaB kinase-alpha by enhancing NF-kappaB-inducing kinase after transient focal cerebral ischemia.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2010;30(7):1265-74.
2010: Joo Eun Jung; Gab Seok Kim; Hai Chen; Carolina M Maier; Purnima Narasimhan; Yun Seon Song; Kuniyasu Niizuma; Masataka Katsu; Nobuya Okami; Hideyuki Yoshioka; Hiroyuki Sakata; Christina E Goeders; Pak H Chan
Reperfusion and neurovascular dysfunction in stroke: from basic mechanisms to potential strategies for neuroprotection.
Molecular neurobiology 2010;41(2-3):172-9.
2010: Kuniyasu Niizuma; Hideyuki Yoshioka; Hai Chen; Gab Seok Kim; Joo Eun Jung; Masataka Katsu; Nobuya Okami; Pak H Chan
Mitochondrial and apoptotic neuronal death signaling pathways in cerebral ischemia.
Biochimica et biophysica acta 2010;1802(1):92-9.
2009: Gab Seok Kim; Joo Eun Jung; Kuniyasu Niizuma; Pak H Chan
CK2 is a novel negative regulator of NADPH oxidase and a neuroprotectant in mice after cerebral ischemia.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2009;29(47):14779-89.
2009: Angela Brennan; Sang Won Suh; Seok Joon Won; Purnima Narasimhan; Tiina M Kauppinen; Hokyou Lee; Ylva Edling; Pak H Chan; Raymond Swanson
NADPH oxidase is the primary source of superoxide induced by NMDA receptor activation.
Nature neuroscience 2009;12(7):857-63.
2009: Yan Xu; Serguei Liachenko; Pei Tang; Pak H Chan
Faster recovery of cerebral perfusion in SOD1-overexpressed rats after cardiac arrest and resuscitation.
Stroke; a journal of cerebral circulation 2009;40(7):2512-8.
2009: Hai Chen; Yun Seon Song; Pak H Chan
Inhibition of NADPH oxidase is neuroprotective after ischemia-reperfusion.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2009;29(7):1262-72.
2009: Joo Eun Jung; Gab Seok Kim; Purnima Narasimhan; Yun Seon Song; Pak H Chan
Regulation of Mn-superoxide dismutase activity and neuroprotection by STAT3 in mice after cerebral ischemia.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2009;29(21):7003-14.
2009: Kuniyasu Niizuma; Hidenori Endo; Pak H Chan
Oxidative stress and mitochondrial dysfunction as determinants of ischemic neuronal death and survival.
Journal of neurochemistry 2009;109 Suppl 1():133-8.
2009: Purnima Narasimhan; Jing Liu; Yun Seon Song; Justin L Massengale; Pak H Chan
VEGF Stimulates the ERK 1/2 signaling pathway and apoptosis in cerebral endothelial cells after ischemic conditions.
Stroke; a journal of cerebral circulation 2009;40(4):1467-73.
2009: Kuniyasu Niizuma; Hidenori Endo; Chikako Nito; D Jeannie Myer; Pak H Chan
Potential role of PUMA in delayed death of hippocampal CA1 neurons after transient global cerebral ischemia.
Stroke; a journal of cerebral circulation 2009;40(2):618-25.
2008: Yun Seon Song; Purnima Narasimhan; Gab Seok Kim; Joo Eun Jung; Eun-Hee Park; Pak H Chan
The role of Akt signaling in oxidative stress mediates NF-kappaB activation in mild transient focal cerebral ischemia.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2008;28(12):1917-26.
2008: Kuniyasu Niizuma; Hidenori Endo; Chikako Nito; D Jeannie Myer; Gab Seok Kim; Pak H Chan
The PIDDosome mediates delayed death of hippocampal CA1 neurons after transient global cerebral ischemia in rats.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(42):16368-73.
2008: Chikako Nito; Hiroshi Kamada; Hidenori Endo; Kuniyasu Niizuma; D Jeannie Myer; Pak H Chan
Role of the p38 mitogen-activated protein kinase/cytosolic phospholipase A2 signaling pathway in blood-brain barrier disruption after focal cerebral ischemia and reperfusion.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2008;28(10):1686-96.
2008: Sang Won Suh; Aaron M Hamby; Elizabeth T Gum; Byung Seop Shin; Seok Joon Won; Christian T Sheline; Pak H Chan; Raymond Swanson
Sequential release of nitric oxide, zinc, and superoxide in hypoglycemic neuronal death.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2008;28(10):1697-706.
2008: Jean-Christophe Copin; Paolo Merlani; Taku Sugawara; Pak H Chan; Yvan Gasche
Delayed matrix metalloproteinase inhibition reduces intracerebral hemorrhage after embolic stroke in rats.
Experimental neurology 2008;213(1):196-201.
2008: Gundars Goldsteins; Velta Keksa-Goldsteine; Toni Ahtoniemi; Merja Jaronen; Egils Arens; Karl Akerman; Pak H Chan; Jari Koistinaho
Deleterious role of superoxide dismutase in the mitochondrial intermembrane space.
The Journal of biological chemistry 2008;283(13):8446-52.
2008: fengshan yu; Hiroshi Kamada; Kuniyasu Niizuma; Hidenori Endo; Pak H Chan
Induction of mmp-9 expression and endothelial injury by oxidative stress after spinal cord injury.
Journal of neurotrauma 2008;25(3):184-95.
2008: fengshan yu; Purnima Narasimhan; Atsushi Saito; Jing Liu; Pak H Chan
Increased expression of a proline-rich Akt substrate (PRAS40) in human copper/zinc-superoxide dismutase transgenic rats protects motor neurons from death after spinal cord injury.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2008;28(1):44-52.
2007: Hidenori Endo; Chikako Nito; Hiroshi Kamada; fengshan yu; Pak H Chan
Reduction in oxidative stress by superoxide dismutase overexpression attenuates acute brain injury after subarachnoid hemorrhage via activation of Akt/glycogen synthase kinase-3beta survival signaling.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2007;27(5):975-82.
2007: Sang Won Suh; Elizabeth T Gum; Aaron M Hamby; Pak H Chan; Raymond Swanson
Hypoglycemic neuronal death is triggered by glucose reperfusion and activation of neuronal NADPH oxidase.
The Journal of clinical investigation 2007;117(4):910-8.
2007: Yun Seon Song; Yong-Sun Lee; Purnima Narasimhan; Pak H Chan
Reduced oxidative stress promotes NF-kappaB-mediated neuroprotective gene expression after transient focal cerebral ischemia: lymphocytotrophic cytokines and antiapoptotic factors.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2007;27(4):764-75.
2007: Hiroshi Kamada; fengshan yu; Chikako Nito; Pak H Chan
Influence of hyperglycemia on oxidative stress and matrix metalloproteinase-9 activation after focal cerebral ischemia/reperfusion in rats: relation to blood-brain barrier dysfunction.
Stroke; a journal of cerebral circulation 2007;38(3):1044-9.
2007: Hiroshi Kamada; Chikako Nito; Hidenori Endo; Pak H Chan
Bad as a converging signaling molecule between survival PI3-K/Akt and death JNK in neurons after transient focal cerebral ischemia in rats.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2007;27(3):521-33.
2006: Carolina M Maier; Lily Hsieh; T Crandall; Purnima Narasimhan; Pak H Chan
A new approach for the investigation of reperfusion-related brain injury.
Biochemical Society transactions 2006;34(Pt 6):1366-9.
2006: H Endo; A Saito; Pak H Chan
Mitochondrial translocation of p53 underlies the selective death of hippocampal CA1 neurons after global cerebral ischaemia.
Biochemical Society transactions 2006;34(Pt 6):1283-6.
2006: Hidenori Endo; Chikako Nito; Hiroshi Kamada; Tatsuro Nishi; Pak H Chan
Activation of the Akt/GSK3beta signaling pathway mediates survival of vulnerable hippocampal neurons after transient global cerebral ischemia in rats.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2006;26(12):1479-89.
2006: Hidenori Endo; Chikako Nito; Hiroshi Kamada; fengshan yu; Pak H Chan
Akt/GSK3beta survival signaling is involved in acute brain injury after subarachnoid hemorrhage in rats.
Stroke; a journal of cerebral circulation 2006;37(8):2140-6.
2006: Yong-Sun Lee; Yun Seon Song; Rona G Giffard; Pak H Chan
Biphasic role of nuclear factor-kappa B on cell survival and COX-2 expression in SOD1 Tg astrocytes after oxygen glucose deprivation.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2006;26(8):1076-88.
2006: Hidenori Endo; Hiroshi Kamada; Chikako Nito; Tatsuro Nishi; Pak H Chan
Mitochondrial translocation of p53 mediates release of cytochrome c and hippocampal CA1 neuronal death after transient global cerebral ischemia in rats.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2006;26(30):7974-83.
2006: Carolina M Maier; Lily Hsieh; Trisha Crandall; Purnima Narasimhan; Pak H Chan
Evaluating therapeutic targets for reperfusion-related brain hemorrhage.
Annals of neurology 2006;59(6):929-38.
2006: Shingo Koyama; Shigeki Arawaka; Ren Chang-Hong; Manabu Wada; Toru Kawanami; Keiji Kurita; Masaaki Kato; Makiko Nagai; Masashi Aoki; Yasuto Itoyama; Gen Sobue; Pak H Chan; Takeo Kato
Alteration of familial ALS-linked mutant SOD1 solubility with disease progression: its modulation by the proteasome and Hsp70.
Biochemical and biophysical research communications 2006;343(3):719-30.
2006: fengshan yu; Taku Sugawara; Tatsuro Nishi; Jing Liu; Pak H Chan
Overexpression of SOD1 in transgenic rats attenuates nuclear translocation of endonuclease G and apoptosis after spinal cord injury.
Journal of neurotrauma 2006;23(5):595-603.
2006: Jing Liu; Purnima Narasimhan; Yong-Sun Lee; Yun Seon Song; Hidenori Endo; fengshan yu; Pak H Chan
Mild hypoxia promotes survival and proliferation of SOD2-deficient astrocytes via c-Myc activation.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2006;26(16):4329-37.
2006: Carolina M Maier; fengshan yu; Tatsuro Nishi; Stephanie J Lathrop; Pak H Chan
Interferon-beta fails to protect in a model of transient focal stroke.
Stroke; a journal of cerebral circulation 2006;37(4):1116-9.
2006: Jing Liu; Purnima Narasimhan; Yun Seon Song; Tatsuro Nishi; fengshan yu; Yong-Sun Lee; Pak H Chan
Epo protects SOD2-deficient mouse astrocytes from damage by oxidative stress.
Glia 2006;53(4):360-5.
2006: Atsushi Saito; Takeshi Hayashi; Shuzo Okuno; Tatsuro Nishi; Pak H Chan
Modulation of proline-rich akt substrate survival signaling pathways by oxidative stress in mouse brains after transient focal cerebral ischemia.
Stroke; a journal of cerebral circulation 2006;37(2):513-7.
2005: Byung In Lee; Pak H Chan; Gyung W Kim
Metalloporphyrin-based superoxide dismutase mimic attenuates the nuclear translocation of apoptosis-inducing factor and the subsequent DNA fragmentation after permanent focal cerebral ischemia in mice.
Stroke; a journal of cerebral circulation 2005;36(12):2712-7.
2005: fengshan yu; Taku Sugawara; Carolina M Maier; Lily B Hsieh; Pak H Chan
Akt/Bad signaling and motor neuron survival after spinal cord injury.
Neurobiology of disease 2005;20(2):491-9.
2005: Yun S Song; Yong-Sun Lee; Pak H Chan
Oxidative stress transiently decreases the IKK complex (IKKalpha, beta, and gamma), an upstream component of NF-kappaB signaling, after transient focal cerebral ischemia in mice.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2005;25(10):1301-11.
2005: Tatsuro Nishi; Carolina M Maier; Takeshi Hayashi; Atsushi Saito; Pak H Chan
Superoxide dismutase 1 overexpression reduces MCP-1 and MIP-1 alpha expression after transient focal cerebral ischemia.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2005;25(10):1312-24.
2005: Jeffrey M Gidday; Yvan G Gasche; Jean-C Copin; Aarti R Shah; Ronald S Perez; Steven D Shapiro; Pak H Chan; Tae S Park
Leukocyte-derived matrix metalloproteinase-9 mediates blood-brain barrier breakdown and is proinflammatory after transient focal cerebral ischemia.
American journal of physiology. Heart and circulatory physiology 2005;289(2):H558-68.
2005: Atsushi Saito; Teiji Tominaga; Pak H Chan
Neuroprotective role of neurotrophins: relationship between nerve growth factor and apoptotic cell survival pathway after cerebral ischemia.
Current atherosclerosis reports 2005;7(4):268-73.
2005: Feng Li; Takeshi Hayashi; Guang Jin; Kentaro Deguchi; Shoko Nagotani; Isao Nagano; Mikio Shoji; Pak H Chan; Koji Abe
The protective effect of dantrolene on ischemic neuronal cell death is associated with reduced expression of endoplasmic reticulum stress markers.
Brain research 2005;1048(1-2):59-68.
2005: Jing Liu; Purnima Narasimhan; fengshan yu; Pak H Chan
Neuroprotection by hypoxic preconditioning involves oxidative stress-mediated expression of hypoxia-inducible factor and erythropoietin.
Stroke; a journal of cerebral circulation 2005;36(6):1264-9.
2005: Pak H Chan
Mitochondrial dysfunction and oxidative stress as determinants of cell death/survival in stroke.
Annals of the New York Academy of Sciences 2005;1042():203-9.
2005: Purnima Narasimhan; Taku Sugawara; Jing Liu; Takeshi Hayashi; Nobuo Noshita; Pak H Chan
Overexpression of human copper/zinc-superoxide dismutase in transgenic animals attenuates the reduction of apurinic/apyrimidinic endonuclease expression in neurons after in vitro ischemia and after transient global cerebral ischemia.
Journal of neurochemistry 2005;93(2):351-8.
2005: Atsushi Saito; Takeshi Hayashi; Shuzo Okuno; Tatsuro Nishi; Pak H Chan
Modulation of p53 degradation via MDM2-mediated ubiquitylation and the ubiquitin-proteasome system during reperfusion after stroke: role of oxidative stress.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2005;25(2):267-80.
2005: Miki Fujimura; Teiji Tominaga; Pak H Chan
Neuroprotective effect of an antioxidant in ischemic brain injury: involvement of neuronal apoptosis.
Neurocritical care 2005;2(1):59-66.
2005: Atsushi Saito; Carolina M Maier; Purnima Narasimhan; Tatsuro Nishi; Yun Seon Song; fengshan yu; Jing Liu; Yong-Sun Lee; Chikako Nito; Hiroshi Kamada; Robert L Dodd; Lily B Hsieh; Benjamin Hassid; Esther E Kim; Maricela González; Pak H Chan
Oxidative stress and neuronal death/survival signaling in cerebral ischemia.
Molecular neurobiology 2005;31(1-3):105-16.
2005: Takeshi Hayashi; Atsushi Saito; Shuzo Okuno; Michel Ferrand-Drake; Robert L Dodd; Pak H Chan
Damage to the endoplasmic reticulum and activation of apoptotic machinery by oxidative stress in ischemic neurons.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2005;25(1):41-53.
2004: Pak H Chan
Mitochondria and neuronal death/survival signaling pathways in cerebral ischemia.
Neurochemical research 2004;29(11):1943-9.
2004: Atsushi Saito; Takeshi Hayashi; Shuzo Okuno; Tatsuro Nishi; Pak H Chan
Oxidative stress affects the integrin-linked kinase signaling pathway after transient focal cerebral ischemia.
Stroke; a journal of cerebral circulation 2004;35(11):2560-5.
2004: Pak H Chan
Future targets and cascades for neuroprotective strategies.
Stroke; a journal of cerebral circulation 2004;35(11 Suppl 1):2748-50.
2004: Shuzo Okuno; Atsushi Saito; Takeshi Hayashi; Pak H Chan
The c-Jun N-terminal protein kinase signaling pathway mediates Bax activation and subsequent neuronal apoptosis through interaction with Bim after transient focal cerebral ischemia.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2004;24(36):7879-87.
2004: Atsushi Saito; Takeshi Hayashi; Shuzo Okuno; Tatsuro Nishi; Pak H Chan
Modulation of the Omi/HtrA2 signaling pathway after transient focal cerebral ischemia in mouse brains that overexpress SOD1.
Brain research. Molecular brain research 2004;127(1-2):89-95.
2004: Wulf Paschen; Takeshi Hayashi; Atsushi Saito; Pak H Chan
GADD34 protein levels increase after transient ischemia in the cortex but not in the CA1 subfield: implications for post-ischemic recovery of protein synthesis in ischemia-resistant cells.
Journal of neurochemistry 2004;90(3):694-701.
2004: Atsushi Saito; Takeshi Hayashi; Shuzo Okuno; Tatsuro Nishi; Pak H Chan
Oxidative stress is associated with XIAP and Smac/DIABLO signaling pathways in mouse brains after transient focal cerebral ischemia.
Stroke; a journal of cerebral circulation 2004;35(6):1443-8.
2004: Carolina M Maier; Lily Hsieh; Fengshan Yu; Paige Bracci; Pak H Chan
Matrix metalloproteinase-9 and myeloperoxidase expression: quantitative analysis by antigen immunohistochemistry in a model of transient focal cerebral ischemia.
Stroke; a journal of cerebral circulation 2004;35(5):1169-74.
2004: Kiyoshi Hirai; Takeshi Hayashi; Pak H Chan; Jianying Zeng; Guo-Yuan Yang; Vladimir J Basus; Tom L James; Lawrence Litt
PI3K inhibition in neonatal rat brain slices during and after hypoxia reduces phospho-Akt and increases cytosolic cytochrome c and apoptosis.
Brain research. Molecular brain research 2004;124(1):51-61.
2004: Takeshi Hayashi; Atsushi Saito; Shuzo Okuno; Michel Ferrand-Drake; Robert L Dodd; Pak H Chan
Oxidative injury to the endoplasmic reticulum in mouse brains after transient focal ischemia.
Neurobiology of disease 2004;15(2):229-39.
2004: Atsushi Saito; Purnima Narasimhan; Takeshi Hayashi; Shuzo Okuno; Michel Ferrand-Drake; Pak H Chan
Neuroprotective role of a proline-rich Akt substrate in apoptotic neuronal cell death after stroke: relationships with nerve growth factor.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2004;24(7):1584-93.
2004: Taku Sugawara; Miki Fujimura; Nobuo Noshita; Gyung W Kim; Atsushi Saito; Takeshi Hayashi; Purnima Narasimhan; Carolina M Maier; Pak H Chan
Neuronal death/survival signaling pathways in cerebral ischemia.
NeuroRx : the journal of the American Society for Experimental NeuroTherapeutics 2004;1(1):17-25.
2003: Candice E Junge; Taku Sugawara; Guido Mannaioni; Sudar Alagarsamy; P Jeffrey Conn; Daniel J Brat; Pak H Chan; Stephen F Traynelis
The contribution of protease-activated receptor 1 to neuronal damage caused by transient focal cerebral ischemia.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(22):13019-24.
2003: Taku Sugawara; Pak H Chan
Reactive oxygen radicals and pathogenesis of neuronal death after cerebral ischemia.
Antioxidants & redox signaling 2003;5(5):597-607.
2003: Takeshi Hayashi; Atsushi Saito; Shuzo Okuno; Michel Ferrand-Drake; Robert L Dodd; Tatsuro Nishi; Carolina M Maier; Hiroyuki Kinouchi; Pak H Chan
Oxidative damage to the endoplasmic reticulum is implicated in ischemic neuronal cell death.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2003;23(10):1117-28.
2003: Gyung W Kim; Yvan Gasche; Susanna M Grzeschik; Jean-Christophe Copin; Carolina M Maier; Pak H Chan
Neurodegeneration in striatum induced by the mitochondrial toxin 3-nitropropionic acid: role of matrix metalloproteinase-9 in early blood-brain barrier disruption?
The Journal of neuroscience : the official journal of the Society for Neuroscience 2003;23(25):8733-42.
2003: Atsushi Saito; Takeshi Hayashi; Shuzo Okuno; Michel Ferrand-Drake; Pak H Chan
Interaction between XIAP and Smac/DIABLO in the mouse brain after transient focal cerebral ischemia.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2003;23(9):1010-9.
2003: Takeshi Hayashi; Atsushi Saito; Shuzo Okuno; Michel Ferrand-Drake; Pak H Chan
Induction of GRP78 by ischemic preconditioning reduces endoplasmic reticulum stress and prevents delayed neuronal cell death.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2003;23(8):949-61.
2003: fengshan yu; Taku Sugawara; Pak H Chan
Treatment with dihydroethidium reduces infarct size after transient focal cerebral ischemia in mice.
Brain research 2003;978(1-2):223-7.
2003: Susanna Koponen; Kaisa Kurkinen; Karl E O Akerman; Daria Mochly-Rosen; Pak H Chan; Jari Koistinaho
Prevention of NMDA-induced death of cortical neurons by inhibition of protein kinase Czeta.
Journal of neurochemistry 2003;86(2):442-50.
2003: Susanna M Grzeschik; Carolina M Maier; Pak H Chan
Effects of cold injury-induced trauma in manganese superoxide dismutase-deficient mice.
Journal of neurotrauma 2003;20(6):571-81.
2003: Michel Ferrand-Drake; Changlian Zhu; Gunilla Gidö; Anders J Hansen; Jan-Olof Karlsson; Ben A Bahr; Naoufal Zamzami; Guido Kroemer; Pak H Chan; Tadeusz Wieloch; Klas Blomgren
Cyclosporin A prevents calpain activation despite increased intracellular calcium concentrations, as well as translocation of apoptosis-inducing factor, cytochrome c and caspase-3 activation in neurons exposed to transient hypoglycemia.
Journal of neurochemistry 2003;85(6):1431-42.
2003: Nobuo Noshita; Taku Sugawara; Anders Lewén; Takeshi Hayashi; Pak H Chan
Copper-zinc superoxide dismutase affects Akt activation after transient focal cerebral ischemia in mice.
Stroke; a journal of cerebral circulation 2003;34(6):1513-8.
2003: Purnima Narasimhan; Miki Fujimura; Nobuo Noshita; Pak H Chan
Role of superoxide in poly(ADP-ribose) polymerase upregulation after transient cerebral ischemia.
Brain research. Molecular brain research 2003;113(1-2):28-36.
2003: Atsushi Saito; Takeshi Hayashi; Shuzo Okuno; Michel Ferrand-Drake; Pak H Chan
Overexpression of copper/zinc superoxide dismutase in transgenic mice protects against neuronal cell death after transient focal ischemia by blocking activation of the Bad cell death signaling pathway.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2003;23(5):1710-8.
2003: Nina Vartiainen; Gundars Goldsteins; Velta Keksa-Goldsteine; Pak H Chan; Jari Koistinaho
Aspirin inhibits p44/42 mitogen-activated protein kinase and is protective against hypoxia/reoxygenation neuronal damage.
Stroke; a journal of cerebral circulation 2003;34(3):752-7.
2003: Takeshi Hayashi; Nobuo Noshita; Taku Sugawara; Pak H Chan
Temporal profile of angiogenesis and expression of related genes in the brain after ischemia.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2003;23(2):166-80.
2003: Kiyoshi Hirai; T Hayashi; Pak H Chan; Vladimir J Basus; Tom L James; Lawrence Litt
Akt phosphorylation and cell survival after hypoxia-induced cytochrome c release in superfused respiring neonatal rat cerebrocortical slices.
Acta neurochirurgica. Supplement 2003;86():227-30.
2003: Matthew B Klein; Pak H Chan; James Chang
Protective effects of superoxide dismutase against ischemia-reperfusion injury: development and application of a transgenic animal model.
Plastic and reconstructive surgery 2003;111(1):251-5; discussion 256-7.
2003: Xinkang Wang; Hugh Wang; Lin Xu; Dennis J Rozanski; Taku Sugawara; Pak H Chan; James M Trzaskos; Giora Z Feuerstein
Significant neuroprotection against ischemic brain injury by inhibition of the MEK1 protein kinase in mice: exploration of potential mechanism associated with apoptosis.
The Journal of pharmacology and experimental therapeutics 2003;304(1):172-8.
2002: Taku Sugawara; Anders Lewén; Yvan Gasche; fengshan yu; Pak H Chan
Overexpression of SOD1 protects vulnerable motor neurons after spinal cord injury by attenuating mitochondrial cytochrome c release.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2002;16(14):1997-9.
2002: Jun Yang; Lori K Klaidman; Artak Nalbandian; Jasmine Oliver; Mei Ling Chang; Pak H Chan; James D Adams
The effects of nicotinamide on energy metabolism following transient focal cerebral ischemia in Wistar rats.
Neuroscience letters 2002;333(2):91-4.
2002: Carolina M Maier; Guo Hua Sun; Danye Cheng; Midori A Yenari; Pak H Chan; Gary K Steinberg
Effects of mild hypothermia on superoxide anion production, superoxide dismutase expression, and activity following transient focal cerebral ischemia.
Neurobiology of disease 2002;11(1):28-42.
2002: Kiyoshi Hirai; Taku Sugawara; Pak H Chan; Vladimir J Basus; Tom L James; Lawrence Litt
Cytochrome c associated apoptosis during ATP recovery after hypoxia in neonatal rat cerebrocortical slices.
Journal of neurochemistry 2002;83(2):309-19.
2002: Nobuo Noshita; Taku Sugawara; Takeshi Hayashi; Anders Lewén; Ghezal Omar; Pak H Chan
Copper/zinc superoxide dismutase attenuates neuronal cell death by preventing extracellular signal-regulated kinase activation after transient focal cerebral ischemia in mice.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2002;22(18):7923-30.
2002: Yasuaki Kokubo; Gerald B Matson; nikita derugin; Tony Hill; Anthony Mancuso; Pak H Chan; Philip R Weinstein
Transgenic mice expressing human copper-zinc superoxide dismutase exhibit attenuated apparent diffusion coefficient reduction during reperfusion following focal cerebral ischemia.
Brain research 2002;947(1):1-8.
2002: Carolina M Maier; Pak H Chan
Role of superoxide dismutases in oxidative damage and neurodegenerative disorders.
The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry 2002;8(4):323-34.
2002: Gyung W Kim; Pak H Chan
Involvement of superoxide in excitotoxicity and DNA fragmentation in striatal vulnerability in mice after treatment with the mitochondrial toxin, 3-nitropropionic acid.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2002;22(7):798-809.
2002: Justin L Massengale; Yvan Gasche; Pak H Chan
Carbohydrate source influences gelatinase production by mouse astrocytes in vitro.
Glia 2002;38(3):240-5.
2002: Mei Ling Chang; Jun Yang; Seyha Kem; Lori K Klaidman; Taku Sugawara; Pak H Chan; James D Adams
Nicotinamide and ketamine reduce infarct volume and DNA fragmentation in rats after brain ischemia and reperfusion.
Neuroscience letters 2002;322(3):137-40.
2002: Nobuo Noshita; Anders Lewén; Taku Sugawara; Pak H Chan
Akt phosphorylation and neuronal survival after traumatic brain injury in mice.
Neurobiology of disease 2002;9(3):294-304.
2002: Gyung W Kim; Takeo Kondo; Nobuo Noshita; Pak H Chan
Manganese superoxide dismutase deficiency exacerbates cerebral infarction after focal cerebral ischemia/reperfusion in mice: implications for the production and role of superoxide radicals.
Stroke; a journal of cerebral circulation 2002;33(3):809-15.
2002: Taku Sugawara; Anders Lewén; Nobuo Noshita; Yvan Gasche; Pak H Chan
Effects of global ischemia duration on neuronal, astroglial, oligodendroglial, and microglial reactions in the vulnerable hippocampal CA1 subregion in rats.
Journal of neurotrauma 2002;19(1):85-98.
2002: Midori A Yenari; Satoshi Iwayama; Danye Cheng; Guo Hua Sun; Miki Fujimura; Yuiko Morita-Fujimura; Pak H Chan; Gary K Steinberg
Mild hypothermia attenuates cytochrome c release but does not alter Bcl-2 expression or caspase activation after experimental stroke.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2002;22(1):29-38.
2002: Taku Sugawara; Nobuo Noshita; Anders Lewén; Yvan Gasche; Michel Ferrand-Drake; Miki Fujimura; Yuiko Morita-Fujimura; Pak H Chan
Overexpression of copper/zinc superoxide dismutase in transgenic rats protects vulnerable neurons against ischemic damage by blocking the mitochondrial pathway of caspase activation.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2002;22(1):209-17.
2001: Nobuo Noshita; Anders Lewén; Taku Sugawara; Pak H Chan
Evidence of phosphorylation of Akt and neuronal survival after transient focal cerebral ischemia in mice.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2001;21(12):1442-50.
2001: Yvan Gasche; Jean-Christophe Copin; Taku Sugawara; Miki Fujimura; Pak H Chan
Matrix metalloproteinase inhibition prevents oxidative stress-associated blood-brain barrier disruption after transient focal cerebral ischemia.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2001;21(12):1393-400.
2001: Taku Sugawara; fengshan yu; L Ma; C J Hsia; Pak H Chan
Delayed treatment with polynitroxyl albumin reduces infarct size after stroke in rats.
Neuroreport 2001;12(16):3609-12.
2001: Taku Sugawara; Nobuo Noshita; Anders Lewén; Gyung W Kim; Pak H Chan
Neuronal expression of the DNA repair protein Ku 70 after ischemic preconditioning corresponds to tolerance to global cerebral ischemia.
Stroke; a journal of cerebral circulation 2001;32(10):2388-93.
2001: Yuiko Morita-Fujimura; Miki Fujimura; T Yoshimoto; Pak H Chan
Superoxide during reperfusion contributes to caspase-8 expression and apoptosis after transient focal stroke.
Stroke; a journal of cerebral circulation 2001;32(10):2356-61.
2001: Paul G Matz; Anders Lewén; Pak H Chan
Neuronal, but not microglial, accumulation of extravasated serum proteins after intracerebral hemolysate exposure is accompanied by cytochrome c release and DNA fragmentation.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2001;21(8):921-8.
2001: Anders Lewén; Miki Fujimura; Taku Sugawara; Paul G Matz; Jean-Christophe Copin; Pak H Chan
Oxidative stress-dependent release of mitochondrial cytochrome c after traumatic brain injury.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2001;21(8):914-20.
2001: A Saito; Hideyuki Kamii; I Kato; S Takasawa; T Kondo; Pak H Chan; Hiroshi Okamoto; Takashi Yoshimoto
Transgenic CuZn-superoxide dismutase inhibits NO synthase induction in experimental subarachnoid hemorrhage.
Stroke; a journal of cerebral circulation 2001;32(7):1652-7.
2001: Anders Lewén; Taku Sugawara; Yvan Gasche; Miki Fujimura; Pak H Chan
Oxidative cellular damage and the reduction of APE/Ref-1 expression after experimental traumatic brain injury.
Neurobiology of disease 2001;8(3):380-90.
2001: Yongmei Chen; Nina Vartiainen; Weihai Ying; Pak H Chan; Jari Koistinaho; Raymond Swanson
Astrocytes protect neurons from nitric oxide toxicity by a glutathione-dependent mechanism.
Journal of neurochemistry 2001;77(6):1601-10.
2001: Gyung W Kim; Nobuo Noshita; Taku Sugawara; Pak H Chan
Early decrease in dna repair proteins, Ku70 and Ku86, and subsequent DNA fragmentation after transient focal cerebral ischemia in mice.
Stroke; a journal of cerebral circulation 2001;32(6):1401-7.
2001: Nobuo Noshita; Taku Sugawara; Miki Fujimura; Yuiko Morita-Fujimura; Pak H Chan
Manganese Superoxide Dismutase Affects Cytochrome c Release and Caspase-9 Activation After Transient Focal Cerebral Ischemia in Mice.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2001;21(5):557-67.
2001: Yongmei Chen; Pak H Chan; Raymond Swanson
Astrocytes overexpressing Cu,Zn superoxide dismutase have increased resistance to oxidative injury.
Glia 2001;33(4):343-7.
2001: C Y Huang; Miki Fujimura; Y Y Chang; Pak H Chan
Overexpression of copper-zinc superoxide dismutase attenuates acute activation of activator protein-1 after transient focal cerebral ischemia in mice.
Stroke; a journal of cerebral circulation 2001;32(3):741-7.
2001: C Y Huang; Miki Fujimura; Nobuo Noshita; Y Y Chang; Pak H Chan
SOD1 down-regulates NF-kappaB and c-Myc expression in mice after transient focal cerebral ischemia.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2001;21(2):163-73.
2001: Gyung W Kim; Pak H Chan
Oxidative stress and neuronal DNA fragmentation mediate age-dependent vulnerability to the mitochondrial toxin, 3-nitropropionic acid, in the mouse striatum.
Neurobiology of disease 2001;8(1):114-26.
2001: Paul G Matz; Miki Fujimura; Anders Lewén; Yuiko Morita-Fujimura; Pak H Chan
Increased cytochrome c-mediated DNA fragmentation and cell death in manganese-superoxide dismutase-deficient mice after exposure to subarachnoid hemolysate.
Stroke; a journal of cerebral circulation 2001;32(2):506-15.
2001: Jean-Christophe Copin; Yvan Gasche; Y Li; Pak H Chan
Prolonged hypoxia during cell development protects mature manganese superoxide dismutase-deficient astrocytes from damage by oxidative stress.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2001;15(2):525-34.
2001: Miki Fujimura; Yuiko Morita-Fujimura; Jean-Christophe Copin; T Yoshimoto; Pak H Chan
Reduction of copper, zinc-superoxide dismutase in knockout mice does not affect edema or infarction volumes and the early release of mitochondrial cytochrome c after permanent focal cerebral ischemia.
Brain research 2001;889(1-2):208-13.
2001: Gyung W Kim; Anders Lewén; Jean-Christophe Copin; Brant D Watson; Pak H Chan
The cytosolic antioxidant, copper/zinc superoxide dismutase, attenuates blood-brain barrier disruption and oxidative cellular injury after photothrombotic cortical ischemia in mice.
Neuroscience 2001;105(4):1007-18.
2001: Glenn T Gobbel; Pak H Chan
Neuronal death is an active, caspase-dependent process after moderate but not severe DNA damage.
Journal of neurochemistry 2001;76(2):520-31.
2001: Nina Vartiainen; C Y Huang; Antero Salminen; Gundars Goldsteins; Pak H Chan; Jari Koistinaho
Piroxicam and NS-398 rescue neurones from hypoxia/reoxygenation damage by a mechanism independent of cyclo-oxygenase inhibition.
Journal of neurochemistry 2001;76(2):480-9.
2001: Pak H Chan
Reactive oxygen radicals in signaling and damage in the ischemic brain.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2001;21(1):2-14.
2000: Gyung W Kim; Taku Sugawara; Pak H Chan
Involvement of oxidative stress and caspase-3 in cortical infarction after photothrombotic ischemia in mice.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2000;20(12):1690-701.
2000: Anders Lewén; Paul G Matz; Pak H Chan
Free radical pathways in CNS injury.
Journal of neurotrauma 2000;17(10):871-90.
2000: Paul G Matz; Jean-Christophe Copin; Pak H Chan
Cell death after exposure to subarachnoid hemolysate correlates inversely with expression of CuZn-superoxide dismutase.
Stroke; a journal of cerebral circulation 2000;31(10):2450-9.
2000: Taku Sugawara; M Kawase; Anders Lewén; Nobuo Noshita; Yvan Gasche; Miki Fujimura; Pak H Chan
Effect of hypotension severity on hippocampal CA1 neurons in a rat global ischemia model.
Brain research 2000;877(2):281-7.
2000: Yongmei Chen; Weihai Ying; V Simma; J C Copin; Pak H Chan; Raymond Swanson
Overexpression of Cu,Zn superoxide dismutase attenuates oxidative inhibition of astrocyte glutamate uptake.
Journal of neurochemistry 2000;75(3):939-45.
2000: Juha Yrjänheikki; Jari Koistinaho; Jean-Christophe Copin; A de Crespigny; Michael E Moseley; Pak H Chan
Spreading depression-induced expression of c-fos and cyclooxygenase-2 in transgenic mice that overexpress human copper/zinc-superoxide dismutase.
Journal of neurotrauma 2000;17(8):713-8.
2000: Miki Fujimura; Yuiko Morita-Fujimura; Nobuo Noshita; T Yoshimoto; Pak H Chan
Reduction of the DNA base excision repair protein, XRCC1, may contribute to DNA fragmentation after cold injury-induced brain trauma in mice.
Brain research 2000;869(1-2):105-11.
2000: Jari Koistinaho; Pak H Chan
Spreading depression-induced cyclooxygenase-2 expression in the cortex.
Neurochemical research 2000;25(5):645-51.
2000: Miki Fujimura; Yuiko Morita-Fujimura; Nobuo Noshita; Taku Sugawara; M Kawase; Pak H Chan
The cytosolic antioxidant copper/zinc-superoxide dismutase prevents the early release of mitochondrial cytochrome c in ischemic brain after transient focal cerebral ischemia in mice.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2000;20(8):2817-24.
2000: Paul G Matz; Miki Fujimura; Pak H Chan
Subarachnoid hemolysate produces DNA fragmentation in a pattern similar to apoptosis in mouse brain.
Brain research 2000;858(2):312-9.
2000: Weihai Ying; Christopher M Anderson; Yongmei Chen; BA Stein; C S Fahlman; J C Copin; Pak H Chan; Raymond Swanson
Differing effects of copper,zinc superoxide dismutase overexpression on neurotoxicity elicited by nitric oxide, reactive oxygen species, and excitotoxins.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2000;20(2):359-68.
2000: Yuiko Morita-Fujimura; Miki Fujimura; Yvan Gasche; Jean-Christophe Copin; Pak H Chan
Overexpression of copper and zinc superoxide dismutase in transgenic mice prevents the induction and activation of matrix metalloproteinases after cold injury-induced brain trauma.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2000;20(1):130-8.
2000: Gyung W Kim; Jean-Christophe Copin; M Kawase; S F Chen; S Sato; Glenn T Gobbel; Pak H Chan
Excitotoxicity is required for induction of oxidative stress and apoptosis in mouse striatum by the mitochondrial toxin, 3-nitropropionic acid.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2000;20(1):119-29.
1999: Y Y Chang; Miki Fujimura; Yuiko Morita-Fujimura; Gyung W Kim; C Y Huang; H S Wu; M Kawase; Jean-Christophe Copin; Pak H Chan
Neuroprotective effects of an antioxidant in cortical cerebral ischemia: prevention of early reduction of the apurinic/apyrimidinic endonuclease DNA repair enzyme.
Neuroscience letters 1999;277(1):61-4.
1999: Juha Yrjänheikki; Tiina M Tikka; Riitta Keinänen; Gundars Goldsteins; Pak H Chan; Jari Koistinaho
A tetracycline derivative, minocycline, reduces inflammation and protects against focal cerebral ischemia with a wide therapeutic window.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(23):13496-500.
1999: M Fujimura; Yuiko Morita-Fujimura; T Sugawara; Pak H Chan
Early decrease of XRCC1, a DNA base excision repair protein, may contribute to DNA fragmentation after transient focal cerebral ischemia in mice.
Stroke; a journal of cerebral circulation 1999;30(11):2456-62; discussion 2463.
1999: M Fujimura; Yuiko Morita-Fujimura; P Narasimhan; Jean-Christophe Copin; M Kawase; Pak H Chan
Copper-zinc superoxide dismutase prevents the early decrease of apurinic/apyrimidinic endonuclease and subsequent DNA fragmentation after transient focal cerebral ischemia in mice.
Stroke; a journal of cerebral circulation 1999;30(11):2408-15.
1999: Miki Fujimura; Yvan Gasche; Yuiko Morita-Fujimura; Justin L Massengale; M Kawase; Pak H Chan
Early appearance of activated matrix metalloproteinase-9 and blood-brain barrier disruption in mice after focal cerebral ischemia and reperfusion.
Brain research 1999;842(1):92-100.
1999: Yvan Gasche; Miki Fujimura; Yuiko Morita-Fujimura; Jean-Christophe Copin; M Kawase; Justin L Massengale; Pak H Chan
Early appearance of activated matrix metalloproteinase-9 after focal cerebral ischemia in mice: a possible role in blood-brain barrier dysfunction.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 1999;19(9):1020-8.
1999: M Kawase; K Murakami; M Fujimura; Yuiko Morita-Fujimura; Yvan Gasche; T Kondo; R W Scott; Pak H Chan
Exacerbation of delayed cell injury after transient global ischemia in mutant mice with CuZn superoxide dismutase deficiency.
Stroke; a journal of cerebral circulation 1999;30(9):1962-8.
1999: Jari Koistinaho; Susanna Koponen; Pak H Chan
Expression of cyclooxygenase-2 mRNA after global ischemia is regulated by AMPA receptors and glucocorticoids.
Stroke; a journal of cerebral circulation 1999;30(9):1900-5; discussion 1905-6.
1999: Y Li; E Carlson; K Murakami; Jean-Christophe Copin; R Luche; S F Chen; C J Epstein; Pak H Chan
Targeted expression of human CuZn superoxide dismutase gene in mouse central nervous system.
Journal of neuroscience methods 1999;89(1):49-55.
1999: Yuiko Morita-Fujimura; Miki Fujimura; M Kawase; S F Chen; Pak H Chan
Release of mitochondrial cytochrome c and DNA fragmentation after cold injury-induced brain trauma in mice: possible role in neuronal apoptosis.
Neuroscience letters 1999;267(3):201-5.
1999: Yuiko Morita-Fujimura; Miki Fujimura; M Kawase; K Murakami; Gyung W Kim; Pak H Chan
Inhibition of interleukin-1beta converting enzyme family proteases (caspases) reduces cold injury-induced brain trauma and DNA fragmentation in mice.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 1999;19(6):634-42.
1999: Miki Fujimura; Yuiko Morita-Fujimura; M Kawase; Pak H Chan
Early decrease of apurinic/apyrimidinic endonuclease expression after transient focal cerebral ischemia in mice.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 1999;19(5):495-501.
1999: Lawrence Litt; MT Espanol; K Hasegawa; LH Chang; George A Gregory; Tom L James; M Flint Beal; Pak H Chan
NOS inhibitors decrease hypoxia-induced ATP reductions in respiring cerebrocortical slices.
Anesthesiology 1999;90(5):1392-401.
1999: M Fujimura; Yuiko Morita-Fujimura; M Kawase; Jean-Christophe Copin; B Calagui; C J Epstein; Pak H Chan
Manganese superoxide dismutase mediates the early release of mitochondrial cytochrome C and subsequent DNA fragmentation after permanent focal cerebral ischemia in mice.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1999;19(9):3414-22.
1999: Hideyuki Kamii; I Kato; Hiroyuki Kinouchi; Pak H Chan; C J Epstein; Atsuya Akabane; Hiroshi Okamoto; Takashi Yoshimoto
Amelioration of vasospasm after subarachnoid hemorrhage in transgenic mice overexpressing CuZn-superoxide dismutase.
Stroke; a journal of cerebral circulation 1999;30(4):867-71; discussion 872.
1999: K Murakami; T Kondo; G Yang; S F Chen; Y Morita-Fujimura; Pak H Chan
Cold injury in mice: a model to study mechanisms of brain edema and neuronal apoptosis.
Progress in neurobiology 1999;57(3):289-99.
1999: Yuiko Morita-Fujimura; Miki Fujimura; M Kawase; Pak H Chan
Early decrease in apurinic/apyrimidinic endonuclease is followed by DNA fragmentation after cold injury-induced brain trauma in mice.
Neuroscience 1999;93(4):1465-73.
1999: Nina Vartiainen; Tiina M Tikka; Riitta Keinänen; Pak H Chan; Jari Koistinaho
Glutamatergic receptors regulate expression, phosphorylation and accumulation of neurofilaments in spinal cord neurons.
Neuroscience 1999;93(3):1123-33.
1999: Susanna Koponen; Riitta Keinänen; Reina Roivainen; T Hirvonen; Matti Närhi; Pak H Chan; Jari Koistinaho
Spreading depression induces expression of calcium-independent protein kinase C subspecies in ischaemia-sensitive cortical layers: regulation by N-methyl-D-aspartate receptors and glucocorticoids.
Neuroscience 1999;93(3):985-93.
1999: Jari Koistinaho; S Pasonen; Juha Yrjänheikki; Pak H Chan
Spreading depression-induced gene expression is regulated by plasma glucose.
Stroke; a journal of cerebral circulation 1999;30(1):114-9.
1998: Y Li; Jean-Christophe Copin; LF Reola; B Calagui; Glenn T Gobbel; S F Chen; S Sato; C J Epstein; Pak H Chan
Reduced mitochondrial manganese-superoxide dismutase activity exacerbates glutamate toxicity in cultured mouse cortical neurons.
Brain research 1998;814(1-2):164-70.
1998: Hiroyuki Kinouchi; Hideyuki Kamii; Shigeki Mikawa; C J Epstein; Takashi Yoshimoto; Pak H Chan
Role of superoxide dismutase in ischemic brain injury: a study using SOD-1 transgenic mice.
Cellular and molecular neurobiology 1998;18(6):609-20.
1998: Miki Fujimura; Yuiko Morita-Fujimura; K Murakami; M Kawase; Pak H Chan
Cytosolic redistribution of cytochrome c after transient focal cerebral ischemia in rats.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 1998;18(11):1239-47.
1998: Pak H Chan; M Kawase; K Murakami; S F Chen; Y Li; B Calagui; LF Reola; E Carlson; C J Epstein
Overexpression of SOD1 in transgenic rats protects vulnerable neurons against ischemic damage after global cerebral ischemia and reperfusion.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1998;18(20):8292-9.
1998: S Sato; Glenn T Gobbel; J Honkaniemi; Y Li; T Kondo; K Murakami; M Sato; Jean-Christophe Copin; Frank R Sharp; Pak H Chan
Decreased expression of bcl-2 and bcl-x mRNA coincides with apoptosis following intracerebral administration of 3-nitropropionic acid.
Brain research 1998;808(1):56-64.
1998: K Murakami; M Kawase; T Kondo; Pak H Chan
Cellular accumulation of extravasated serum protein and DNA fragmentation following vasogenic edema.
Journal of neurotrauma 1998;15(10):825-35.
1998: Heather J Fullerton; J S Ditelberg; S F Chen; D P Sarco; Pak H Chan; C J Epstein; Donna M Ferriero
Copper/zinc superoxide dismutase transgenic brain accumulates hydrogen peroxide after perinatal hypoxia ischemia.
Annals of neurology 1998;44(3):357-64.
1998: Y Li; Pak H Chan
Identification of the pro-oncogene stathmin/op18 mRNA in the brain of mitochondrial Mn-superoxide dismutase-deficient mice by a modified differential display PCR.
Brain research. Molecular brain research 1998;55(2):277-84.
1998: K Hasegawa; Lawrence Litt; MT Espanol; Frank R Sharp; Pak H Chan
Expression of c-fos and hsp70 mRNA in neonatal rat cerebrocortical slices during NMDA-induced necrosis and apoptosis.
Brain research 1998;785(2):262-78.
1998: Jean-Christophe Copin; Y Li; LF Reola; Pak H Chan
Trolox and 6,7-dinitroquinoxaline-2,3-dione prevent necrosis but not apoptosis in cultured neurons subjected to oxygen deprivation.
Brain research 1998;784(1-2):25-36.
1998: MT Espanol; Lawrence Litt; K Hasegawa; LH Chang; Jeffrey Macdonald; George A Gregory; Tom L James; Pak H Chan
Fructose-1,6-bisphosphate preserves adenosine triphosphate but not intracellular pH during hypoxia in respiring neonatal rat brain slices.
Anesthesiology 1998;88(2):461-72.
1998: K Murakami; T Kondo; M Kawase; Pak H Chan
The development of a new mouse model of global ischemia: focus on the relationships between ischemia duration, anesthesia, cerebral vasculature, and neuronal injury following global ischemia in mice.
Brain research 1998;780(2):304-10.
1998: K Murakami; T Kondo; M Kawase; Y Li; S Sato; S F Chen; Pak H Chan
Mitochondrial susceptibility to oxidative stress exacerbates cerebral infarction that follows permanent focal cerebral ischemia in mutant mice with manganese superoxide dismutase deficiency.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1998;18(1):205-13.
1998: Glenn T Gobbel; M Bellinzona; A R Vogt; Naveen Gupta; John R Fike; Pak H Chan
Response of postmitotic neurons to X-irradiation: implications for the role of DNA damage in neuronal apoptosis.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1998;18(1):147-55.
1997: K Murakami; T Kondo; S Sato; Y Li; Pak H Chan
Occurrence of apoptosis following cold injury-induced brain edema in mice.
Neuroscience 1997;81(1):231-7.
1997: Glenn T Gobbel; T Y Chan; Pak H Chan
Nitric oxide- and superoxide-mediated toxicity in cerebral endothelial cells.
The Journal of pharmacology and experimental therapeutics 1997;282(3):1600-7.
1997: K Murakami; T Kondo; C J Epstein; Pak H Chan
Overexpression of CuZn-superoxide dismutase reduces hippocampal injury after global ischemia in transgenic mice.
Stroke; a journal of cerebral circulation 1997;28(9):1797-804.
1997: T T Huang; M Yasunami; Elaine J Carlson; A M Gillespie; Andrew G Reaume; EK Hoffman; Pak H Chan; Richard W Scott; C J Epstein
Superoxide-mediated cytotoxicity in superoxide dismutase-deficient fetal fibroblasts.
Archives of biochemistry and biophysics 1997;344(2):424-32.
1997: T Kondo; Andrew G Reaume; T T Huang; E Carlson; K Murakami; S F Chen; EK Hoffman; Richard W Scott; C J Epstein; Pak H Chan
Reduction of CuZn-superoxide dismutase activity exacerbates neuronal cell injury and edema formation after transient focal cerebral ischemia.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1997;17(11):4180-9.
1997: K Murakami; T Kondo; Pak H Chan
Reperfusion following focal cerebral ischemia alters distribution of neuronal cells with DNA fragmentation in mice.
Brain research 1997;751(1):160-4.
1997: K Hasegawa; Lawrence Litt; MT Espanol; George A Gregory; Frank R Sharp; Pak H Chan
Effects of neuroprotective dose of fructose-1,6-bisphosphate on hypoxia-induced expression of c-fos and hsp70 mRNA in neonatal rat cerebrocortical slices.
Brain research 1997;750(1-2):1-10.
1997: T Kondo; Frank R Sharp; J Honkaniemi; S Mikawa; C J Epstein; Pak H Chan
DNA fragmentation and Prolonged expression of c-fos, c-jun, and hsp70 in kainic acid-induced neuronal cell death in transgenic mice overexpressing human CuZn-superoxide dismutase.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 1997;17(3):241-56.
1997: S Sato; Glenn T Gobbel; J Honkaniemi; Y Li; T Kondo; K Murakami; M Sato; Jean-Christophe Copin; Pak H Chan
Apoptosis in the striatum of rats following intraperitoneal injection of 3-nitropropionic acid.
Brain research 1997;745(1-2):343-7.
1997: S Sato; Glenn T Gobbel; Y Li; T Kondo; K Murakami; M Sato; K Hasegawa; Jean-Christophe Copin; J Honkaniemi; Frank R Sharp; Pak H Chan
Blood-brain barrier disruption, HSP70 expression and apoptosis due to 3-nitropropionic acid, a mitochondrial toxin.
Acta neurochirurgica. Supplement 1997;70():237-9.
1997: K Murakami; T Kondo; Pak H Chan
Blood-brain barrier disruption, edema formation, and apoptotic neuronal death following cold injury.
Acta neurochirurgica. Supplement 1997;70():234-6.
1997: T Kondo; Andrew G Reaume; T T Huang; K Murakami; E Carlson; S Chen; Richard W Scott; C J Epstein; Pak H Chan
Edema formation exacerbates neurological and histological outcomes after focal cerebral ischemia in CuZn-superoxide dismutase gene knockout mutant mice.
Acta neurochirurgica. Supplement 1997;70():62-4.
1996: Hideyuki Kamii; Shigeki Mikawa; K Murakami; Hiroyuki Kinouchi; Takashi Yoshimoto; L Reola; E Carlson; Charles J Epstein; Pak H Chan
Effects of nitric oxide synthase inhibition on brain infarction in SOD-1-transgenic mice following transient focal cerebral ischemia.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 1996;16(6):1153-7.
1996: Shigeki Mikawa; Hiroyuki Kinouchi; Hideyuki Kamii; Glenn T Gobbel; S F Chen; Elaine Carlson; Charles J Epstein; Pak H Chan
Attenuation of acute and chronic damage following traumatic brain injury in copper, zinc-superoxide dismutase transgenic mice.
Journal of neurosurgery 1996;85(5):885-91.
1996: T Kondo; K Murakami; J Honkaniemi; Frank R Sharp; Charles J Epstein; Pak H Chan
Expression of hsp70 mRNA is induced in the brain of transgenic mice overexpressing human CuZn-superoxide dismutase following transient global cerebral ischemia.
Brain research 1996;737(1-2):321-6.
1996: S Imaizumi; T Kondo; Mária A Deli; G Gobbel; F Joó; Charles J Epstein; Takashi Yoshimoto; Pak H Chan
The influence of oxygen free radicals on the permeability of the monolayer of cultured brain endothelial cells.
Neurochemistry international 1996;29(2):205-11.
1996: J A Kelleher; T Y Chan; Pak H Chan; George A Gregory
Protection of astrocytes by fructose 1,6-bisphosphate and citrate ameliorates neuronal injury under hypoxic conditions.
Brain research 1996;726(1-2):167-73.
1996: Pak H Chan
Role of oxidants in ischemic brain damage.
Stroke; a journal of cerebral circulation 1996;27(6):1124-9.
1996: M C Longuemare; E C Keung; S Chun; Frank R Sharp; Pak H Chan; Raymond Swanson
MK-801 reduces uptake and stimulates efflux of excitatory amino acids via membrane depolarization.
The American journal of physiology 1996;270(5 Pt 1):C1398-404.
1996: Jean-Christophe Copin; L F Reola; T Y Chan; Y Li; Charles J Epstein; Pak H Chan
Oxygen deprivation but not a combination of oxygen, glucose, and serum deprivation induces DNA degradation in mouse cortical neurons in vitro: attenuation by transgenic overexpression of CuZn-superoxide dismutase.
Journal of neurotrauma 1996;13(5):233-44.
1996: Pak H Chan; Charles J Epstein; Hiroyuki Kinouchi; Hideyuki Kamii; S F Chen; E Carlson; J Gafni; G Yang; L Reola
Neuroprotective role of CuZn-superoxide dismutase in ischemic brain damage.
Advances in neurology 1996;71():271-280.
1996: MT Espanol; Lawrence Litt; L H Chang; Tom L James; Philip R Weinstein; Pak H Chan
Adult rat brain-slice preparation for nuclear magnetic resonance spectroscopy studies of hypoxia.
Anesthesiology 1996;84(1):201-10.
1995: Y Li; Ting-Ting Huang; Elaine J Carlson; Simon Melov; P C Ursell; J L Olson; L J Noble; M P Yoshimura; C Berger; Pak H Chan; Douglas C Wallace; Charles J Epstein
Dilated cardiomyopathy and neonatal lethality in mutant mice lacking manganese superoxide dismutase.
Nature genetics 1995;11(4):376-81.
1995: Pak H Chan; Charles J Epstein; Y Li; T T Huang; E Carlson; Hiroyuki Kinouchi; G Yang; Hideyuki Kamii; Shigeki Mikawa; T Kondo
Transgenic mice and knockout mutants in the study of oxidative stress in brain injury.
Journal of neurotrauma 1995;12(5):815-24.
1995: J A Kelleher; Pak H Chan; T Y Chan; George A Gregory
Energy metabolism in hypoxic astrocytes: protective mechanism of fructose-1,6-bisphosphate.
Neurochemical research 1995;20(7):785-92.
1995: Glenn T Gobbel; T Y Chan; Pak H Chan
Amelioration of hypoxic and hypoglycemic damage to cerebral endothelial cells. Effects of heat shock pretreatment.
Molecular and chemical neuropathology / sponsored by the International Society for Neurochemistry and the World Federation of Neurology and research groups on neurochemistry and cerebrospinal fluid 1995;24(2-3):107-20.
1995: J Chen; Steven H Graham; Pak H Chan; J Lan; R L Zhou; Roger P. Simon
bcl-2 is expressed in neurons that survive focal ischemia in the rat.
Neuroreport 1995;6(2):394-8.
1994: T Kondo; S Imaizumi; I Kato; Mária A Deli; F Jóo; Pak H Chan; Charles J Epstein; Takashi Yoshimoto
[Effect of free radicals on the permeability of the blood brain barrier--using in vitro blood brain barrier model of human-SOD transgenic mouse].
Nō to shinkei = Brain and nerve 1994;46(12):1155-61.
1994: Pak H Chan; Charles J Epstein; Hiroyuki Kinouchi; Hideyuki Kamii; S Imaizumi; G Yang; S F Chen; J Gafni; E Carlson
SOD-1 transgenic mice as a model for studies of neuroprotection in stroke and brain trauma.
Annals of the New York Academy of Sciences 1994;738():93-103.
1994: Hideyuki Kamii; Hiroyuki Kinouchi; Frank R Sharp; Charles J Epstein; S M Sagar; Pak H Chan
Expression of c-fos mRNA after a mild focal cerebral ischemia in SOD-1 transgenic mice.
Brain research 1994;662(1-2):240-4.
1994: Hiroyuki Kinouchi; Frank R Sharp; Pak H Chan; Shigeki Mikawa; Hideyuki Kamii; S Arai; Takashi Yoshimoto
MK-801 inhibits the induction of immediate early genes in cerebral cortex, thalamus, and hippocampus, but not in substantia nigra following middle cerebral artery occlusion.
Neuroscience letters 1994;179(1-2):111-4.
1994: Hiroyuki Kinouchi; Frank R Sharp; Pak H Chan; J Koistinaho; S M Sagar; Takashi Yoshimoto
Induction of c-fos, junB, c-jun, and hsp70 mRNA in cortex, thalamus, basal ganglia, and hippocampus following middle cerebral artery occlusion.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 1994;14(5):808-17.
1994: Glenn T Gobbel; T Y Chan; George A Gregory; Pak H Chan
Response of cerebral endothelial cells to hypoxia: modification by fructose-1,6-bisphosphate but not glutamate receptor antagonists.
Brain research 1994;653(1-2):23-30.
1994: H Karibe; S F Chen; G J Zarow; J Gafni; Steven H Graham; Pak H Chan; Philip R Weinstein
Mild intraischemic hypothermia suppresses consumption of endogenous antioxidants after temporary focal ischemia in rats.
Brain research 1994;649(1-2):12-8.
1994: MT Espanol; Lawrence Litt; Y Xu; L H Chang; Tom L James; Philip R Weinstein; Pak H Chan
19F NMR calcium changes, edema and histology in neonatal rat brain slices during glutamate toxicity.
Brain research 1994;647(1):172-6.
1994: Hideyuki Kamii; Hiroyuki Kinouchi; Frank R Sharp; Jari Koistinaho; Charles J Epstein; Pak H Chan
Prolonged expression of hsp70 mRNA following transient focal cerebral ischemia in transgenic mice overexpressing CuZn-superoxide dismutase.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 1994;14(3):478-86.
1994: J Mintorovitch; G Y Yang; H Shimizu; J Kucharczyk; Pak H Chan; Philip R Weinstein
Diffusion-weighted magnetic resonance imaging of acute focal cerebral ischemia: comparison of signal intensity with changes in brain water and Na+,K(+)-ATPase activity.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 1994;14(2):332-6.
1994: MT Espanol; Y Xu; Lawrence Litt; G Y Yang; L H Chang; Tom L James; P Weinstein; Pak H Chan
Modulation of glutamate-induced intracellular energy failure in neonatal cerebral cortical slices by kynurenic acid, dizocilpine, and NBQX.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 1994;14(2):269-78.
1994: G Yang; Pak H Chan; S F Chen; O A Babuna; Roger P. Simon; Philip R Weinstein
Reduction of vasogenic edema and infarction by MK-801 in rats after temporary focal cerebral ischemia.
Neurosurgery 1994;34(2):339-45; discussion 345.
1994: J A Kelleher; George A Gregory; Pak H Chan
Effect of fructose-1,6-bisphosphate on glutamate uptake and glutamine synthetase activity in hypoxic astrocyte cultures.
Neurochemical research 1994;19(2):209-15.
1994: G Yang; Pak H Chan; J Chen; Elaine Carlson; S F Chen; P Weinstein; Charles J Epstein; Hideyuki Kamii
Human copper-zinc superoxide dismutase transgenic mice are highly resistant to reperfusion injury after focal cerebral ischemia.
Stroke; a journal of cerebral circulation 1994;25(1):165-70.
1994: MT Espanol; Y Xu; Lawrence Litt; L H Chang; Tom L James; Philip R Weinstein; Pak H Chan
Modulation of edema by dizocilpine, kynurenate, and NBQX in respiring brain slices after exposure to glutamate.
Acta neurochirurgica. Supplementum 1994;60():58-61.
1994: S Imaizumi; L Chang; Y Cohen; Pak H Chan; Philip R Weinstein; T Yoshimoto; Tom L James
Reduction of superoxide dismutase activity correlates with visualization of edema by T2-weighted MR imaging in focal ischemic rat brain.
Neurologia medico-chirurgica 1994;34(1):1-9.
1993: Pak H Chan; Hideyuki Kamii; G Yang; J Gafni; Charles J Epstein; Elaine Carlson; L Reola
Brain infarction is not reduced in SOD-1 transgenic mice after a permanent focal cerebral ischemia.
Neuroreport 1993;5(3):293-6.
1993: Frank R Sharp; Hiroyuki Kinouchi; Jari Koistinaho; Pak H Chan; S M Sagar
HSP70 heat shock gene regulation during ischemia.
Stroke; a journal of cerebral circulation 1993;24(12 Suppl):I72-5.
1993: Hiroyuki Kinouchi; Frank R Sharp; Jari Koistinaho; K Hicks; Hideyuki Kamii; Pak H Chan
Induction of heat shock hsp70 mRNA and HSP70 kDa protein in neurons in the 'penumbra' following focal cerebral ischemia in the rat.
Brain research 1993;619(1-2):334-8.
1993: J A Kelleher; Pak H Chan; T Y Chan; George A Gregory
Modification of hypoxia-induced injury in cultured rat astrocytes by high levels of glucose.
Stroke; a journal of cerebral circulation 1993;24(6):855-63.
1993: K Hirose; Pak H Chan
Blockade of glutamate excitotoxicity and its clinical applications.
Neurochemical research 1993;18(4):479-83.
1993: Hiroyuki Kinouchi; Frank R Sharp; M P Hill; Jari Koistinaho; S M Sagar; Pak H Chan
Induction of 70-kDa heat shock protein and hsp70 mRNA following transient focal cerebral ischemia in the rat.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 1993;13(1):105-15.
1993: Philip H Gutin; K J Levin; Michael W McDermott; N Hooper; M T Smith; J R Cashman; Pak H Chan; G Y Ross; Theodore L Phillips; Victor Levin
Lipid peroxidation does not appear to be a factor in late radiation injury of the cervical spinal cord of rats.
International journal of radiation oncology, biology, physics 1993;25(1):67-72.
1993: Pak H Chan; Hiroyuki Kinouchi; Charles J Epstein; Elaine Carlson; S F Chen; S Imaizumi; G Y Yang
Role of superoxide dismutase in ischemic brain injury: reduction of edema and infarction in transgenic mice following focal cerebral ischemia.
Progress in brain research 1993;96():97-104.
1992: MT Espanol; Lawrence Litt; G Y Yang; L H Chang; Pak H Chan; Tom L James; Philip R Weinstein
Tolerance of low intracellular pH during hypercapnia by rat cortical brain slices: A 31P/1H NMR study.
Journal of neurochemistry 1992;59(5):1820-8.
1992: G Y Yang; S F Chen; Hiroyuki Kinouchi; Pak H Chan; Philip R Weinstein
Edema, cation content, and ATPase activity after middle cerebral artery occlusion in rats.
Stroke; a journal of cerebral circulation 1992;23(9):1331-6.
1992: Pak H Chan
Antioxidant-dependent amelioration of brain injury: role of CuZn-superoxide dismutase.
Journal of neurotrauma 1992;9 Suppl 2():S417-23.
1992: T Mizui; Hiroyuki Kinouchi; Pak H Chan
Depletion of brain glutathione by buthionine sulfoximine enhances cerebral ischemic injury in rats.
The American journal of physiology 1992;262(2 Pt 2):H313-7.
1992: Linda J Noble; J J Hall; S Chen; Pak H Chan
Morphologic changes in cultured astrocytes after exposure to glutamate.
Journal of neurotrauma 1992;9(3):255-67.
1991: Hiroyuki Kinouchi; Charles J Epstein; T Mizui; Elaine Carlson; S F Chen; Pak H Chan
Attenuation of focal cerebral ischemic injury in transgenic mice overexpressing CuZn superoxide dismutase.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(24):11158-62.
1991: E Dux; Linda J Noble; Pak H Chan
Glutamine stimulates growth in rat cerebral endothelial cell culture.
Journal of neuroscience research 1991;29(3):355-61.
1991: Pak H Chan; G Y Yang; S F Chen; E Carlson; Charles J Epstein
Cold-induced brain edema and infarction are reduced in transgenic mice overexpressing CuZn-superoxide dismutase.
Annals of neurology 1991;29(5):482-6.
1990: Pak H Chan; L Chu; S F Chen; Elaine J Carlson; Charles J Epstein
Reduced neurotoxicity in transgenic mice overexpressing human copper-zinc-superoxide dismutase.
Stroke; a journal of cerebral circulation 1990;21(11 Suppl):III80-2.
1990: S Imaizumi; V Woolworth; R A Fishman; Pak H Chan
Liposome-entrapped superoxide dismutase reduces cerebral infarction in cerebral ischemia in rats.
Stroke; a journal of cerebral circulation 1990;21(9):1312-7.
1990: George A Gregory; F A Welsh; A C Yu; Pak H Chan
Fructose-1,6-bisphosphate reduces ATP loss from hypoxic astrocytes.
Brain research 1990;516(2):310-2.
1990: B M Pereira; Pak H Chan; Philip R Weinstein; R A Fishman
Cerebral protection during reperfusion with superoxide dismutase in focal cerebral ischemia.
Advances in neurology 1990;52():97-103.
1990: Pak H Chan; R A Fishman; M A Wesley; S Longar
Pathogenesis of vasogenic edema in focal cerebral ischemia. Role of superoxide radicals.
Advances in neurology 1990;52():177-83.
1990: Charles J Epstein; C N Berger; Elaine J Carlson; Pak H Chan; Ting-Ting Huang
Models for Down syndrome: chromosome 21-specific genes in mice.
Progress in clinical and biological research 1990;360():215-32.
1990: Philip H Gutin; Michael W McDermott; G Ross; Pak H Chan; S F Chen; K J Levin; O Babuna; L J Marton
Polyamine accumulation and vasogenic oedema in the genesis of late delayed radiation injury of the central nervous system (CNS).
Acta neurochirurgica. Supplementum 1990;51():372-4.
1990: S Imaizumi; V Woolworth; H Kinouchi; S F Chen; R A Fishman; Pak H Chan
Liposome-entrapped superoxide dismutase ameliorates infarct volume in focal cerebral ischaemia.
Acta neurochirurgica. Supplementum 1990;51():236-8.
1990: Pak H Chan; L Chu
Mechanisms underlying glutamate-induced swelling of astrocytes in primary culture.
Acta neurochirurgica. Supplementum 1990;51():7-10.
1990: Pak H Chan; L Chu; S F Chen; Elaine J Carlson; Charles J Epstein
Attenuation of glutamate-induced neuronal swelling and toxicity in transgenic mice overexpressing human CuZn-superoxide dismutase.
Acta neurochirurgica. Supplementum 1990;51():245-7.
1990: Pak H Chan; L Chu; S Chen
Effects of MK-801 on glutamate-induced swelling of astrocytes in primary cell culture.
Journal of neuroscience research 1990;25(1):87-93.
1989: L Hillered; Pak H Chan
Brain mitochondrial swelling induced by arachidonic acid and other long chain free fatty acids.
Journal of neuroscience research 1989;24(2):247-50.
1989: Pak H Chan; L Chu
Ketamine protects cultured astrocytes from glutamate-induced swelling.
Brain research 1989;487(2):380-3.
1989: George A Gregory; A C Yu; Pak H Chan
Fructose-1,6-bisphosphate protects astrocytes from hypoxic damage.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 1989;9(1):29-34.
1989: A C Yu; George A Gregory; Pak H Chan
Hypoxia-induced dysfunctions and injury of astrocytes in primary cell cultures.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 1989;9(1):20-8.
1989: Pak H Chan; S Longar; S Chen; A C Yu; L Hillered; L Chu; S Imaizumi; B Pereira; K Moore; V Woolworth
The role of arachidonic acid and oxygen radical metabolites in the pathogenesis of vasogenic brain edema and astrocytic swelling.
Annals of the New York Academy of Sciences 1989;559():237-47.
1988: L Hillered; Pak H Chan
Role of arachidonic acid and other free fatty acids in mitochondrial dysfunction in brain ischemia.
Journal of neuroscience research 1988;20(4):451-6.
1988: Pak H Chan; S F Chen; A C Yu
Induction of intracellular superoxide radical formation by arachidonic acid and by polyunsaturated fatty acids in primary astrocytic cultures.
Journal of neurochemistry 1988;50(4):1185-93.
1988: Pak H Chan; L Chu; R A Fishman
Reduction of activities of superoxide dismutase but not of glutathione peroxidase in rat brain regions following decapitation ischemia.
Brain research 1988;439(1-2):388-90.
1988: L Hillered; Pak H Chan
Effects of arachidonic acid on respiratory activities in isolated brain mitochondria.
Journal of neuroscience research 1988;19(1):94-100.
1987: Pak H Chan; S Longar; R A Fishman
Protective effects of liposome-entrapped superoxide dismutase on posttraumatic brain edema.
Annals of neurology 1987;21(6):540-7.
1987: Pak H Chan; S Chen; R A Fishman
Effects of exogenous phospholipases on brain membrane phospholipid perturbation, (Na(+) + K(+))-ATPase activity and cellular swelling of brain slices.
Neurochemistry international 1987;10(3):303-10.
1985: Pak H Chan; R A Fishman; S Longar; S Chen; A Yu
Cellular and molecular effects of polyunsaturated fatty acids in brain ischemia and injury.
Progress in brain research 1985;63():227-35.
1984: Pak H Chan; J W Schmidley; R A Fishman; S M Longar
Brain injury, edema, and vascular permeability changes induced by oxygen-derived free radicals.
Neurology 1984;34(3):315-20.
1984: Pak H Chan; R A Fishman; J W Schmidley; S F Chen
Release of polyunsaturated fatty acids from phospholipids and alteration of brain membrane integrity by oxygen-derived free radicals.
Journal of neuroscience research 1984;12(4):595-605.
1983: Pak H Chan; S Longar; R A Fishman
Phospholipid degradation and edema development in cold-injured rat brain.
Brain research 1983;277(2):329-37.
1983: Pak H Chan; R A Fishman; J Caronna; J W Schmidley; G Prioleau; J Lee
Induction of brain edema following intracerebral injection of arachidonic acid.
Annals of neurology 1983;13(6):625-32.