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Rebecca Chan

Research Profile

Chemicals & Drugs

Living Beings

Anatomy

Physiology

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Phosphorylation

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Juvenile Myelomonocytic Leukemia

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Publications

TOP 3
S C Nabinger; B Ramdas; B Richine; G E Sandusky; M Yu; L Zeng; X Zhang; Z-Y Zhang; G-S Feng; Seiji Fukuda; Shreevrat Goenka; Y He; Reuben Kapur; X J Li; Z Liu; H Scott Boswell; J D Bowling; Rebecca J Chan
The protein tyrosine phosphatase, Shp2, positively contributes to FLT3-ITD-induced hematopoietic progenitor hyperproliferation and malignant disease in vivo.
Timothy A Sutton; Momoko Yoshimoto; Melissa Anderson; Rebecca J Chan; Takashi Hato; Sarah Kuehl; Erik Mai; Henry E Mang; Zoya Plotkin; Pierre C Dagher
p53 is renoprotective after ischemic kidney injury by reducing inflammation.
Raghuveer S Mali; Holly Martin; Veerendra Munugalavadla; Sarah Nabinger; Baskar Ramdas; George Sandusky; Namit Sharma; Emily Sims; Li-Fan Zeng; Zhong-Yin Zhang; Kevin D Bunting; Rebecca J Chan; Anindya Chatterjee; Andrew W B Craig; Gen-Sheng Feng; Joydeep Ghosh; Yantao He; Shuo Li; Peilin Ma; Reuben Kapur
Role of SHP2 phosphatase in KIT-induced transformation: identification of SHP2 as a druggable target in diseases involving oncogenic KIT.

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All Publications

2013: S C Nabinger; B Ramdas; B Richine; G E Sandusky; M Yu; L Zeng; X Zhang; Z-Y Zhang; G-S Feng; Seiji Fukuda; Shreevrat Goenka; Y He; Reuben Kapur; X J Li; Z Liu; H Scott Boswell; J D Bowling; Rebecca J Chan
The protein tyrosine phosphatase, Shp2, positively contributes to FLT3-ITD-induced hematopoietic progenitor hyperproliferation and malignant disease in vivo.
Leukemia 2013;27(2):398-408.
2013: Timothy A Sutton; Momoko Yoshimoto; Melissa Anderson; Rebecca J Chan; Takashi Hato; Sarah Kuehl; Erik Mai; Henry E Mang; Zoya Plotkin; Pierre C Dagher
p53 is renoprotective after ischemic kidney injury by reducing inflammation.
Journal of the American Society of Nephrology : JASN 2013;24(1):113-24.
2012: Raghuveer S Mali; Holly Martin; Veerendra Munugalavadla; Sarah Nabinger; Baskar Ramdas; George Sandusky; Namit Sharma; Emily Sims; Li-Fan Zeng; Zhong-Yin Zhang; Kevin D Bunting; Rebecca J Chan; Anindya Chatterjee; Andrew W B Craig; Gen-Sheng Feng; Joydeep Ghosh; Yantao He; Shuo Li; Peilin Ma; Reuben Kapur
Role of SHP2 phosphatase in KIT-induced transformation: identification of SHP2 as a druggable target in diseases involving oncogenic KIT.
Blood 2012;120(13):2669-78.
2012: Sarah C Nabinger; Rebecca J Chan
Shp2 function in hematopoietic stem cell biology and leukemogenesis.
Current opinion in hematology 2012;19(4):273-9.
2012: Charles B Goodwin; Zhenyun Yang; Fuqin Yin; Menggang Yu; Rebecca J Chan
Genetic disruption of the PI3K regulatory subunits, p85α, p55α, and p50α, normalizes mutant PTPN11-induced hypersensitivity to GM-CSF.
Haematologica 2012;97(7):1042-7.
2011: Emily G Farrow; James C Fleet; Holly J Garringer; Charles B Goodwin; Siu L Hui; Victoria Jideonwo; Martin J Magers; Munro Peacock; Alexander G Robling; Keith R Stayrook; Lelia J Summers; Ruben Vidal; Matthew R Allen; Rebecca J Chan; Siobhan I Davis; Xijie Yu; Kenneth E White
Iron deficiency drives an autosomal dominant hypophosphatemic rickets (ADHR) phenotype in fibroblast growth factor-23 (Fgf23) knock-in mice.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(46):E1146-55.
2011: Mia Chen; Sarah Burgin; Rebecca J Chan; Yongzheng He; David Ingram; Li Jiang; Xiaohong Li; Mikella Robinson; Karl Staser; D Wade Clapp
Kinase suppressor of Ras (KSR1) modulates multiple kit-ligand-dependent mast cell functions.
Experimental hematology 2011;39(10):969-76.
2011: Peilin Ma; Raghuveer Singh Mali; Holly Martin; Veerendra Munugalavadla; Baskar Ramdas; Emily Sims; Clifford M Takemoto; Rebecca J Chan; Andrew W Craig; Joydeep Ghosh; Subha Krishnan; Gerald Krystal; Shuo Li; Reuben Kapur
The PI3K pathway drives the maturation of mast cells via microphthalmia transcription factor.
Blood 2011;118(13):3459-69.
2011: Raghuveer Singh Mali; Veerendra Munugalavadla; Sarah C Nabinger; Baskar Ramdas; Jianjian Shi; Emily Sims; Andrew M Stern; Ramon V Tiu; Fabiola Traina; Sasidhar Vemula; Valeria Visconte; Lei Wei; Qiang Wen; H Scott Boswell; Rebecca J Chan; John D Crispino; Charles B Goodwin; Timothy A Lewis; Peilin Ma; Reuben Kapur
Rho kinase regulates the survival and transformation of cells bearing oncogenic forms of KIT, FLT3, and BCR-ABL.
Cancer cell 2011;20(3):357-69.
2011: Hamid Sayar; Amanda Walter; Evan S West; Jingwei Wu; Zhenyun Yang; Zhangsheng Yu; Daniel Hood; Chua Lin Hui; Kristopher J Kohlbacher; Sarah C Nabinger; Christie M Orschell; Artur Plett; Carol Sampson; Edward M Chan; Rebecca J Chan; Larry D Cripe
Thrice weekly azacitidine does not improve hematological responses in lower-risk myelodysplastic syndromes: a study of the Hoosier Oncology Group.
Leukemia research 2011;35(8):1108-10.
2011: Zhenyun Yang; Fuqin Yin; Menggang Yu; Mia Chen; Tirajeh Saadatzadeh; Sarah A Sitarski; Feng-Chun Yang; Rebecca J Chan
Genetic disruption of the scaffolding protein, Kinase Suppressor of Ras 1 (KSR1), differentially regulates GM-CSF-stimulated hyperproliferation in hematopoietic progenitors expressing activating PTPN11 mutants D61Y and E76K.
Leukemia research 2011;35(7):961-4.
2011: Takako Kondo; Akihiro J Matsuoka; Atsushi Shimomura; Karl Russell Koehler; Rebecca J Chan; Josef M Miller; Edward F Srour; Eri Hashino
Wnt signaling promotes neuronal differentiation from mesenchymal stem cells through activation of Tlx3.
Stem cells (Dayton, Ohio) 2011;29(5):836-46.
2011: Shanbao Cai; Haiyan Wang; Barbara Bailey; Aaron Ernstberger; Beth E Juliar; Anthony L Sinn; Rebecca J Chan; David R Jones; Lindsey D Mayo; Arthur R Baluyut; W Scott Goebel; Karen E Pollok
Humanized bone marrow mouse model as a preclinical tool to assess therapy-mediated hematotoxicity.
Clinical cancer research : an official journal of the American Association for Cancer Research 2011;17(8):2195-206.
2011: Sijiu Liu; Zhihong Yu; Xiao Yu; Sheng-Xiong Huang; Yinggang Luo; Li Wu; Weihua Shen; Zhenyun Yang; Lina Wang; Andrea M Gunawan; Rebecca J Chan; Ben Shen; Zhong-Yin Zhang
SHP2 is a target of the immunosuppressant tautomycetin.
Chemistry & biology 2011;18(1):101-10.
2010: Xian Zhang; Yantao He; Sijiu Liu; Zhihong Yu; Zhong Jiang; Zhenyun Yang; Yuanshu Dong; Sarah C Nabinger; Li Wu; Andrea M Gunawan; Lina Wang; Rebecca J Chan; Zhong-Yin Zhang
Salicylic acid based small molecule inhibitor for the oncogenic Src homology-2 domain containing protein tyrosine phosphatase-2 (SHP2).
Journal of medicinal chemistry 2010;53(6):2482-93.
2010: Bo Zhou; Yantao He; Xian Zhang; Jie Xu; Yong Luo; Yuehong Wang; Scott Franzblau; Zhenyun Yang; Rebecca J Chan; Yan Liu; Jianyu Zheng; Zhong-Yin Zhang
Targeting mycobacterium protein tyrosine phosphatase B for antituberculosis agents.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(10):4573-8.
2009: Zhenyun Yang; Takako Kondo; Cara S Voorhorst; Sarah C Nabinger; Leila Ndong; Fuqin Yin; Edward M Chan; Menggang Yu; Oliver Würstlin; Christian P Kratz; Charlotte M Niemeyer; Christian Flotho; Eri Hashino; Rebecca J Chan
Increased c-Jun expression and reduced GATA2 expression promote aberrant monocytic differentiation induced by activating PTPN11 mutants.
Molecular and cellular biology 2009;29(16):4376-93.
2009: Rebecca J Chan; Todd Cooper; Christian P Kratz; Brian Weiss; Mignon L Loh
Juvenile myelomonocytic leukemia: a report from the 2nd International JMML Symposium.
Leukemia research 2009;33(3):355-62.
2009: Michael L Goodman; Shi Chen; Feng-Chun Yang; Rebecca J Chan
Novel method of murine embryonic stem cell-derived osteoclast development.
Stem cells and development 2009;18(1):195-200.
2008: Zhenyun Yang; Yiping Li; Fuqin Yin; Rebecca J Chan
Activating PTPN11 mutants promote hematopoietic progenitor cell-cycle progression and survival.
Experimental hematology 2008;36(10):1285-96.
2008: Takako Kondo; Patrick L Sheets; David A Zopf; Heather L Aloor; Theodore R Cummins; Rebecca J Chan; Eri Hashino
Tlx3 exerts context-dependent transcriptional regulation and promotes neuronal differentiation from embryonic stem cells.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(15):5780-5.
2008: Jincheng Yan; Shi Chen; Yingze Zhang; Xiaohong Li; Yan Li; Xiaohua Wu; Jin Yuan; Alexander G Robling; Reuben Kapur; Reuben Karpur; Rebecca J Chan; Feng-Chun Yang
Rac1 mediates the osteoclast gains-in-function induced by haploinsufficiency of Nf1.
Human molecular genetics 2008;17(7):936-48.
2008: Veerendra Munugalavadla; Emily C Sims; Rebecca J Chan; Stephen D Lenz; Reuben Kapur
Requirement for p85alpha regulatory subunit of class IA PI3K in myeloproliferative disease driven by an activation loop mutant of KIT.
Experimental hematology 2008;36(3):301-8.
2007: Edward M Chan; Rebecca J Chan; Elisha M Comer; Robert J Goulet; Colin D Crean; Zachary D Brown; Amy M Fruehwald; Zhenyun Yang; H Scott Boswell; Harikrishna Nakshatri; Theodore G Gabig
MOZ and MOZ-CBP cooperate with NF-kappaB to activate transcription from NF-kappaB-dependent promoters.
Experimental hematology 2007;35(12):1782-92.
2007: Veerendra Munugalavadla; Emily C Sims; Jovencio Borneo; Rebecca J Chan; Reuben Kapur
Genetic and pharmacologic evidence implicating the p85 alpha, but not p85 beta, regulatory subunit of PI3K and Rac2 GTPase in regulating oncogenic KIT-induced transformation in acute myeloid leukemia and systemic mastocytosis.
Blood 2007;110(5):1612-20.
2007: Rebecca J Chan; Gen-Sheng Feng
PTPN11 is the first identified proto-oncogene that encodes a tyrosine phosphatase.
Blood 2007;109(3):862-7.
2006: Rebecca J Chan; Yanjun Li; Meredith N Hass; Amanda Walter; Cara S Voorhorst; William C Shelley; Zhenyun Yang; Christie M Orschell; Mervin C Yoder
Shp-2 heterozygous hematopoietic stem cells have deficient repopulating ability due to diminished self-renewal.
Experimental hematology 2006;34(9):1230-9.
2006: Gang-Ming Zou; Rebecca J Chan; W Christopher Shelley; Mervin C Yoder
Reduction of Shp-2 expression by small interfering RNA reduces murine embryonic stem cell-derived in vitro hematopoietic differentiation.
Stem cells (Dayton, Ohio) 2006;24(3):587-94.
2006: Rebecca J Chan; Robert Hromas; Mervin C Yoder
The role of Hex in hemangioblast and hematopoietic development.
Methods in molecular biology (Clifton, N.J.) 2006;330():123-33.
2005: Edward M Chan; Elisha M Comer; Frank C Brown; Kathleen E Richkind; Melissa L Holmes; Beng H Chong; Roger Shiffman; Dong-Er Zhang; Marilyn L Slovak; Cheryl L Willman; Constance T Noguchi; Yanjun Li; Devan J Heiber; Lori Kwan; Rebecca J Chan; Gail H Vance; Heather Ramsey; Robert Hromas
AML1-FOG2 fusion protein in myelodysplasia.
Blood 2005;105(11):4523-6.
2005: Rebecca J Chan; Melissa B Leedy; Veerendra Munugalavadla; Cara S Voorhorst; Yanjun Li; Menggang Yu; Reuben Kapur
Human somatic PTPN11 mutations induce hematopoietic-cell hypersensitivity to granulocyte-macrophage colony-stimulating factor.
Blood 2005;105(9):3737-42.
2005: Yanjun Li; Jeanette McClintick; Li Zhong; Howard J Edenberg; Mervin C Yoder; Rebecca J Chan
Murine embryonic stem cell differentiation is promoted by SOCS-3 and inhibited by the zinc finger transcription factor Klf4.
Blood 2005;105(2):635-7.
2004: Li Zhong; Weiming Li; Zuocheng Yang; Keyun Qing; Mengqun Tan; Jonathan Hansen; Yanjun Li; Linyuan Chen; Rebecca J Chan; Daniela Bischof; Njeri Maina; Kirsten A Weigel-Kelley; Weihong Zhao; Steven H Larsen; Mervin C Yoder; Weinian Shou; Arun Srivastava
Impaired nuclear transport and uncoating limit recombinant adeno-associated virus 2 vector-mediated transduction of primary murine hematopoietic cells.
Human gene therapy 2004;15(12):1207-18.
2004: Li Zhong; Linyuan Chen; Yanjun Li; Keyun Qing; Kirsten A Weigel-Kelley; Rebecca J Chan; Mervin C Yoder; Arun Srivastava
Self-complementary adeno-associated virus 2 (AAV)-T cell protein tyrosine phosphatase vectors as helper viruses to improve transduction efficiency of conventional single-stranded AAV vectors in vitro and in vivo.
Molecular therapy : the journal of the American Society of Gene Therapy 2004;10(5):950-7.
2004: Rebecca J Chan; Mervin C Yoder
The multiple facets of hematopoietic stem cells.
Current neurovascular research 2004;1(3):197-206.
2004: Rebecca J Chan; Min You; Gen-Sheng Feng
Identification of trans-acting factors by electrophoretic mobility shift assay.
Methods in molecular biology (Clifton, N.J.) 2004;249():7-20.
2003: Rebecca J Chan; Scott A Johnson; Yanjun Li; Mervin C Yoder; Gen-Sheng Feng
A definitive role of Shp-2 tyrosine phosphatase in mediating embryonic stem cell differentiation and hematopoiesis.
Blood 2003;102(6):2074-80.
2003: Xiaodong Xie; Rebecca J Chan; Scott A Johnson; Mark Starr; Jennifer McCarthy; Reuben Kapur; Mervin C Yoder
Thrombopoietin promotes mixed lineage and megakaryocytic colony-forming cell growth but inhibits primitive and definitive erythropoiesis in cells isolated from early murine yolk sacs.
Blood 2003;101(4):1329-35.
2002: Xiaodong Xie; Rebecca J Chan; Mervin C Yoder
Thrombopoietin acts synergistically with LIF to maintain an undifferentiated state of embryonic stem cells homozygous for a Shp-2 deletion mutation.
FEBS letters 2002;529(2-3):361-4.
2001: James Palis; Rebecca J Chan; Anne Koniski; R Patel; M Starr; Mervin C Yoder
Spatial and temporal emergence of high proliferative potential hematopoietic precursors during murine embryogenesis.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(8):4528-33.
2000: John W Hawes; David W Crabb; Rebecca J Chan; P M Rougraff; ralph paxton; Robert Harris
Mammalian 3-hydroxyisobutyrate dehydrogenase.
Methods in enzymology 2000;324():218-28.