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Tak Hang Chan

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Kristin Landis-Piwowar; Robert Foldes; Tak Hang Chan; Di Chen; Qingping Dou
Novel epigallocatechin gallate analogs as potential anticancer agents: a patent review (2009 - present).
Chi Chiu Wang; Hui Xu; Tao Zhang; Jimmy Tin Yan Cheng; Ching Yan Chu; Kai On Chu; Yi Xin He; Joseph Kwong; Tat San Lau; Gang Li; Gene Chi Wai Man; Ling Qin; Tak Hang Chan
Prodrug of green tea epigallocatechin-3-gallate (Pro-EGCG) as a potent anti-angiogenesis agent for endometriosis in mice.
Iris L K Wong; Kin-Fai Chan; Tak Hang Chan; Larry M C Chow
Flavonoid dimers as novel, potent antileishmanial agents.

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All Publications

2013: Kristin Landis-Piwowar; Robert Foldes; Tak Hang Chan; Di Chen; Qingping Dou
Novel epigallocatechin gallate analogs as potential anticancer agents: a patent review (2009 - present).
Expert opinion on therapeutic patents 2013;23(2):189-202.
2013: Chi Chiu Wang; Hui Xu; Tao Zhang; Jimmy Tin Yan Cheng; Ching Yan Chu; Kai On Chu; Yi Xin He; Joseph Kwong; Tat San Lau; Gang Li; Gene Chi Wai Man; Ling Qin; Tak Hang Chan
Prodrug of green tea epigallocatechin-3-gallate (Pro-EGCG) as a potent anti-angiogenesis agent for endometriosis in mice.
Angiogenesis 2013;16(1):59-69.
2012: Iris L K Wong; Kin-Fai Chan; Tak Hang Chan; Larry M C Chow
Flavonoid dimers as novel, potent antileishmanial agents.
Journal of medicinal chemistry 2012;55(20):8891-902.
2012: Min Shen; Tak Hang Chan; Qingping Dou
Targeting tumor ubiquitin-proteasome pathway with polyphenols for chemosensitization.
Anti-cancer agents in medicinal chemistry 2012;12(8):891-901.
2012: Fung-Yi Chan; Tak Hang Chan; Yun-Chung Leung; Marco A C Neves; Ning Sun; Emily Tsang; Ruben Abagyan; Kwok-Yin Wong
Validation of the AmpC β-lactamase binding site and identification of inhibitors with novel scaffolds.
Journal of chemical information and modeling 2012;52(5):1367-75.
2012: Di Chen; Qiuzhi Cui; Tak Hang Chan; Sreedhar Pamu; Qingping Dou
Novel epigallocatechin gallate (EGCG) analogs activate AMP-activated protein kinase pathway and target cancer stem cells.
Bioorganic & medicinal chemistry 2012;20(9):3031-7.
2012: Kin-Fai Chan; Larry M C Chow; Jason W Y Kan; Iris L K Wong; Clare S W Yan; Tak Hang Chan
Amine linked flavonoid dimers as modulators for P-glycoprotein-based multidrug resistance: structure-activity relationship and mechanism of modulation.
Journal of medicinal chemistry 2012;55(5):1999-2014.
2012: Taskeen Mujtaba; Sheng Biao Wan; Tak Hang Chan; Jyoti Kanwar; Qingping Dou
Sensitizing human multiple myeloma cells to the proteasome inhibitor bortezomib by novel curcumin analogs.
International journal of molecular medicine 2012;29(1):102-6.
2011: Syed M Meeran; Shweta N Patel; Tak Hang Chan; Trygve O Tollefsbol
A novel prodrug of epigallocatechin-3-gallate: differential epigenetic hTERT repression in human breast cancer cells.
Cancer prevention research (Philadelphia, Pa.) 2011;4(8):1243-54.
2011: Di Chen; Sheng Biao Wan; Huanjie Yang; Jian Yuan; Tak Hang Chan; Qingping Dou
EGCG, green tea polyphenols and their synthetic analogs and prodrugs for human cancer prevention and treatment.
Advances in clinical chemistry 2011;53():155-77.
2010: Kar Lok Kong; Dora L W Kwong; Li Fu; Tak Hang Chan; Leilei Chen; Haibo Liu; Yan Li; Ying-Hui Zhu; Jiong Bi; Yan-Ru Qin; Simon Ying-Kit Law; Xin-Yuan Guan
Characterization of a candidate tumor suppressor gene uroplakin 1A in esophageal squamous cell carcinoma.
Cancer research 2010;70(21):8832-41.
2010: Sheng Biao Wan; Huanjie Yang; Zhongyuan Zhou; Qiuzhi Cindy Cui; Di Chen; Jyoti Kanwar; Imthiyaz Mohammad; Qingping Dou; Tak Hang Chan
Evaluation of curcumin acetates and amino acid conjugates as proteasome inhibitors.
International journal of molecular medicine 2010;26(4):447-55.
2010: Kam-Piu Ho; Wing-Leung WONG; Lawrence Yoon Suk Lee; Kin-Ming Lam; Tak Hang Chan; Kwok-Yin Wong
Manganese acetate in pyrrolidinium ionic liquid as a robust and efficient catalytic system for epoxidation of aliphatic terminal alkenes.
Chemistry, an Asian journal 2010;5(9):1970-3.
2010: Kristin Landis-Piwowar; Di Chen; Tak Hang Chan; Qingping Dou
Inhibition of catechol-Omicron-methyltransferase activity in human breast cancer cells enhances the biological effect of the green tea polyphenol (-)-EGCG.
Oncology reports 2010;24(2):563-9.
2010: Jyoti Kanwar; Imthiyaz Mohammad; Huanjie Yang; Congde Huo; Tak Hang Chan; Qingping Dou
Computational modeling of the potential interactions of the proteasome beta5 subunit and catechol-O-methyltransferase-resistant EGCG analogs.
International journal of molecular medicine 2010;26(2):209-15.
2010: Congde Huo; Tak Hang Chan
A novel liquid-phase strategy for organic synthesis using organic ions as soluble supports.
Chemical Society reviews 2010;39(8):2977-3006.
2010: Olivier Baslé; Nadine Borduas; Pauline Dubois; Jean Marc Chapuzet; Tak Hang Chan; Jean Lessard; Chao-Jun Li
Aerobic and electrochemical oxidative cross-dehydrogenative-coupling (CDC) reaction in an imidazolium-based ionic liquid.
Chemistry (Weinheim an der Bergstrasse, Germany) 2010;16(27):8162-6.
2010: Andrew Davenport; Michael Frezza; Min Shen; Yubin Ge; Congde Huo; Tak Hang Chan; Qingping Dou
Celastrol and an EGCG pro-drug exhibit potent chemosensitizing activity in human leukemia cells.
International journal of molecular medicine 2010;25(3):465-70.
2010: Congde Huo; Huanjie Yang; Qiuzhi Cindy Cui; Qingping Dou; Tak Hang Chan
Proteasome inhibition in human breast cancer cells with high catechol-O-methyltransferase activity by green tea polyphenol EGCG analogs.
Bioorganic & medicinal chemistry 2010;18(3):1252-8.
2010: Jianfei Chao; Way Kwok-Wai Lau; Michelle Justine Huie; Yuen-Shan Ho; Man-Shan Yu; Cora Sau-Wan Lai; Mingfu Wang; Wai-Hung Yuen; Wai Har Lam; Tak Hang Chan; Raymond Chuen-Chung Chang
A pro-drug of the green tea polyphenol (-)-epigallocatechin-3-gallate (EGCG) prevents differentiated SH-SY5Y cells from toxicity induced by 6-hydroxydopamine.
Neuroscience letters 2010;469(3):360-4.
2009: Iris L K Wong; Kin-Fai Chan; Ka Hing Tsang; Chi Yin Lam; Yunzhe Zhao; Tak Hang Chan; Larry M C Chow
Modulation of multidrug resistance protein 1 (MRP1/ABCC1)-mediated multidrug resistance by bivalent apigenin homodimers and their derivatives.
Journal of medicinal chemistry 2009;52(17):5311-22.
2009: Leilei Chen; Liang Hu; Tak Hang Chan; George S W Tsao; Dan Xie; Ke-Ke Huo; Li Fu; Stephanie Ma; Bo-Jian Zheng; Xin-Yuan Guan
Chromodomain helicase/adenosine triphosphatase DNA binding protein 1-like (CHD1l) gene suppresses the nucleus-to-mitochondria translocation of nur77 to sustain hepatocellular carcinoma cell survival.
Hepatology (Baltimore, Md.) 2009;50(1):122-9.
2009: Iris L K Wong; Kin-Fai Chan; Yunzhe Zhao; Tak Hang Chan; Larry M C Chow
Quinacrine and a novel apigenin dimer can synergistically increase the pentamidine susceptibility of the protozoan parasite Leishmania.
The Journal of antimicrobial chemotherapy 2009;63(6):1179-90.
2009: Kin-Fai Chan; Yunzhe Zhao; Toby W S Chow; Clare S W Yan; Dik-Lung Ma; Brendan A Burkett; Iris L K Wong; Larry M C Chow; Tak Hang Chan
Flavonoid dimers as bivalent modulators for p-glycoprotein-based multidrug resistance: structure-activity relationships.
ChemMedChem 2009;4(4):594-614.
2009: Larry M C Chow; Tak Hang Chan
Novel classes of dimer antitumour drug candidates.
Current pharmaceutical design 2009;15(6):659-74.
2008: Congde Huo; Xun He; Tak Hang Chan
Zwitterionic phosphonium sulfonates as easily phase-separable ion-tagged Wittig reagents.
The Journal of organic chemistry 2008;73(21):8583-6.
2008: Di Chen; Vesna Milacic; Marina S Chen; Sheng Biao Wan; Wai Har Lam; C Huo; Kristin R Landis-Piwowar; Qiuzhi Cindy Cui; A Wali; Tak Hang Chan; Qingping Dou
Tea polyphenols, their biological effects and potential molecular targets.
Histology and histopathology 2008;23(4):487-96.
2008: Kam-Piu Ho; Wing-Leung WONG; Kin-Ming Lam; Cheuk-Piu Lai; Tak Hang Chan; Kwok-Yin Wong
A simple and effective catalytic system for epoxidation of aliphatic terminal alkenes with manganese(II) as the catalyst.
Chemistry (Weinheim an der Bergstrasse, Germany) 2008;14(26):7988-96.
2008: Suk-Ching Lee; Wing-Ki Chan; Tak-Wing Lee; Wai Har Lam; Xianghong Wang; Tak Hang Chan; Yong-Chuan Wong
Effect of a prodrug of the green tea polyphenol (-)-epigallocatechin-3-gallate on the growth of androgen-independent prostate cancer in vivo.
Nutrition and cancer 2008;60(4):483-91.
2008: Alain Lesimple; Xun He; Tak Hang Chan; Orval Mamer
Collision-induced dissociation of sulfur-containing imidazolium ionic liquids.
Journal of mass spectrometry : JMS 2008;43(1):35-41.
2007: Hong Yee Cheung; Wing-Yiu Yu; Fuk Loi Lam; Terry T-L Au-Yeung; Zhongyuan Zhou; Tak Hang Chan; Albert S C Chan
Enantioselective Pd-catalyzed allylic alkylation of indoles by a new class of chiral ferrocenyl P/S ligands.
Organic letters 2007;9(21):4295-8.
2007: Kristin R Landis-Piwowar; Sheng Biao Wan; Richard A Wiegand; Deborah J. Kuhn; Tak Hang Chan; Qingping Dou
Methylation suppresses the proteasome-inhibitory function of green tea polyphenols.
Journal of cellular physiology 2007;213(1):252-60.
2007: Kumi Osanai; Kristin R Landis-Piwowar; Qingping Dou; Tak Hang Chan
A para-amino substituent on the D-ring of green tea polyphenol epigallocatechin-3-gallate as a novel proteasome inhibitor and cancer cell apoptosis inducer.
Bioorganic & medicinal chemistry 2007;15(15):5076-82.
2007: Xun He; Tak Hang Chan
Structurally defined imidazolium-type ionic oligomers as soluble/solid support for peptide synthesis.
Organic letters 2007;9(14):2681-4.
2007: Kristin R Landis-Piwowar; Congde Huo; Di Chen; Vesna Milacic; Guoqing Shi; Tak Hang Chan; Qingping Dou
A novel prodrug of the green tea polyphenol (-)-epigallocatechin-3-gallate as a potential anticancer agent.
Cancer research 2007;67(9):4303-10.
2007: Iris L K Wong; Kin-Fai Chan; Brendan A Burkett; Yunzhe Zhao; Yi Chai; Hongzhe Sun; Tak Hang Chan; Larry M C Chow
Flavonoid dimers as bivalent modulators for pentamidine and sodium stiboglucanate resistance in leishmania.
Antimicrobial agents and chemotherapy 2007;51(3):930-40.
2007: Man Chun Law; Tin Wai Cheung; Kwok-Yin Wong; Tak Hang Chan
Synthetic and mechanistic studies of indium-mediated allylation of imines in ionic liquids.
The Journal of organic chemistry 2007;72(3):923-9.
2007: Robert A Donga; Matthew Hassler; Tak Hang Chan; Masad J Damha
Oligonucleotide synthesis using ionic liquids as soluble supports.
Nucleosides, nucleotides & nucleic acids 2007;26(10-12):1287-93.
2006: Kristin R Landis-Piwowar; Vesna Milacic; Di Chen; Huanjie Yang; Yunfeng Zhao; Tak Hang Chan; Bing Yan; Qingping Dou
The proteasome as a potential target for novel anticancer drugs and chemosensitizers.
Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy 2006;9(6):263-73.
2006: Weishi Miao; Tak Hang Chan
Ionic-liquid-supported synthesis: a novel liquid-phase strategy for organic synthesis.
Accounts of chemical research 2006;39(12):897-908.
2006: Kin-Fai Chan; Yunzhe Zhao; Brendan A Burkett; Iris L K Wong; Larry M C Chow; Tak Hang Chan
Flavonoid dimers as bivalent modulators for P-glycoprotein-based multidrug resistance: synthetic apigenin homodimers linked with defined-length poly(ethylene glycol) spacers increase drug retention and enhance chemosensitivity in resistant cancer cells.
Journal of medicinal chemistry 2006;49(23):6742-59.
2006: Kenyon G Daniel; Kristin R Landis-Piwowar; Di Chen; Sheng Biao Wan; Tak Hang Chan; Qingping Dou
Methylation of green tea polyphenols affects their binding to and inhibitory poses of the proteasome beta5 subunit.
International journal of molecular medicine 2006;18(4):625-32.
2006: Robert A Donga; Syed M Khaliq-Uz-Zaman; Tak Hang Chan; Masad J Damha
A novel approach to oligonucleotide synthesis using an imidazolium ion tag as a soluble support.
The Journal of organic chemistry 2006;71(20):7907-10.
2006: Man Chun Law; Kwok-Yin Wong; Tak Hang Chan
Grignard reagents in ionic liquids.
Chemical communications (Cambridge, England) 2006;(23):2457-9.
2006: Alain Lesimple; Orval Mamer; Weishi Miao; Tak Hang Chan
Electrospray mass spectral fragmentation study of N,N'-disubstituted imidazolium ionic liquids.
Journal of the American Society for Mass Spectrometry 2006;17(1):85-95.
2005: Man Chun Law; Kwok-Yin Wong; Tak Hang Chan
Formation and reactions of alkylzinc reagents in room-temperature ionic liquids.
The Journal of organic chemistry 2005;70(25):10434-9.
2005: Weishi Miao; Tak Hang Chan
Ionic-liquid-supported peptide synthesis demonstrated by the synthesis of Leu(5)-enkephalin.
The Journal of organic chemistry 2005;70(8):3251-5.
2005: Kristin R Landis-Piwowar; Deborah J. Kuhn; Sheng Biao Wan; Di Chen; Tak Hang Chan; Qingping Dou
Evaluation of proteasome-inhibitory and apoptosis-inducing potencies of novel (-)-EGCG analogs and their prodrugs.
International journal of molecular medicine 2005;15(4):735-42.
2005: Sheng Biao Wan; Kristin R Landis-Piwowar; Deborah J. Kuhn; Di Chen; Qingping Dou; Tak Hang Chan
Structure-activity study of epi-gallocatechin gallate (EGCG) analogs as proteasome inhibitors.
Bioorganic & medicinal chemistry 2005;13(6):2177-85.
2005: Michael Chi-Yung Tang; Kwok-Yin Wong; Tak Hang Chan
Electrosynthesis of hydrogen peroxide in room temperature ionic liquids and in situ epoxidation of alkenes.
Chemical communications (Cambridge, England) 2005;(10):1345-7.
2005: Alain Lesimple; Marcos Di Falco; Yannick Richard; Souad Lesimple; Zhigang Wang; Tak Hang Chan; Orval Mamer
Multiple losses of neutral C14H14 in the tandem mass spectrometry of several perbenzyl ether intermediates in the synthesis of green tea constituents.
Rapid communications in mass spectrometry : RCM 2005;19(22):3253-8.
2005: Deborah J. Kuhn; Wai Har Lam; Aslamuzzaman Kazi; Kenyon G Daniel; Shuojing Song; Larry M C Chow; Tak Hang Chan; Qingping Dou
Synthetic peracetate tea polyphenols as potent proteasome inhibitors and apoptosis inducers in human cancer cells.
Frontiers in bioscience : a journal and virtual library 2005;10():1010-23.
2004: Wai Har Lam; Aslamuzzaman Kazi; Deborah J. Kuhn; Larry M C Chow; Albert S C Chan; Qingping Dou; Tak Hang Chan
A potential prodrug for a green tea polyphenol proteasome inhibitor: evaluation of the peracetate ester of (-)-epigallocatechin gallate [(-)-EGCG].
Bioorganic & medicinal chemistry 2004;12(21):5587-93.
2004: Weishi Miao; Lung Wa Chung; Yun-Dong Wu; Tak Hang Chan
Experimental and theoretical studies of the propargyl-allenylindium system.
Journal of the American Chemical Society 2004;126(41):13326-34.
2004: Di Chen; Kenyon G Daniel; Deborah J. Kuhn; Aslamuzzaman Kazi; Mohammad Bhuiyan; Lianhai Li; Zhigang Wang; Sheng Biao Wan; Wai Har Lam; Tak Hang Chan; Qingping Dou
Green tea and tea polyphenols in cancer prevention.
Frontiers in bioscience : a journal and virtual library 2004;9():2618-31.
2004: Sheng Biao Wan; Di Chen; Qingping Dou; Tak Hang Chan
Study of the green tea polyphenols catechin-3-gallate (CG) and epicatechin-3-gallate (ECG) as proteasome inhibitors.
Bioorganic & medicinal chemistry 2004;12(13):3521-7.
2004: Aslamuzzaman Kazi; Zhigang Wang; Naveen Kumar; Samuel C Falsetti; Tak Hang Chan; Qingping Dou
Structure-activity relationships of synthetic analogs of (-)-epigallocatechin-3-gallate as proteasome inhibitors.
Anticancer research 2004;24(2B):943-54.
2004: David M Smith; Kenyon G Daniel; Zhigang Wang; Wayne C Guida; Tak Hang Chan; Qingping Dou
Docking studies and model development of tea polyphenol proteasome inhibitors: applications to rational drug design.
Proteins 2004;54(1):58-70.
2003: Weishi Miao; Tak Hang Chan
Exploration of ionic liquids as soluble supports for organic synthesis. Demonstration with a Suzuki coupling reaction.
Organic letters 2003;5(26):5003-5.
2003: Kit-Ho Tong; Kwok-Yin Wong; Tak Hang Chan
Manganese/Bicarbonate-catalyzed epoxidation of lipophilic alkenes with hydrogen peroxide in ionic liquids.
Organic letters 2003;5(19):3423-5.
2003: Weishi Miao; Wenshuo Lu; Tak Hang Chan
Remarkable 1,6-acyclic diastereoselection in the coupling of a novel butadienyl di-indium compound with aldehydes.
Journal of the American Chemical Society 2003;125(9):2412-3.
2002: David M Smith; Zhigang Wang; Aslamuzzaman Kazi; Lian-Hai Li; Tak Hang Chan; Qingping Dou
Synthetic analogs of green tea polyphenols as proteasome inhibitors.
Molecular medicine (Cambridge, Mass.) 2002;8(7):382-92.
2001: W Lu; Tak Hang Chan
Indium-mediated organometallic reactions in aqueous media. Stereoselectivity in the crotylation of sulfonimines bearing a proximal chelating group.
The Journal of organic chemistry 2001;66(10):3467-73.
2001: L Li; Tak Hang Chan
Enantioselective synthesis of epigallocatechin-3-gallate (EGCG), the active polyphenol component from green tea.
Organic letters 2001;3(5):739-41.
2000: W Lu; Tak Hang Chan
Organometallic reactions in aqueous media. Indium- and zinc-mediated allylation of sulfonimines.
The Journal of organic chemistry 2000;65(25):8589-94.
1998: P Jones; G B Villeneuve; C Fei; J DeMarte; A J Haggarty; K T Nwe; D A Martin; Anne-Marie Lebuis; J M Finkelstein; B J Gour-Salin; Tak Hang Chan; Brian Leyland-Jones
Synthesis and structure-activity relationships of 2-pyrazinylcarboxamidobenzoates and beta-ionylideneacetamidobenzoates with retinoidal activity.
Journal of medicinal chemistry 1998;41(16):3062-77.