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Navdeep Chandel

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Michael S Schieber; Navdeep S Chandel
ROS links glucose metabolism to breast cancer stem cell and EMT phenotype.
Laura A Sena; Chyung-Ru Wang; Paul J Bryce; Teresa Ezponda; David A Hildeman; Amit Jairaman; Sha Li; Jonathan D Licht; Harris Perlman; Murali Prakriya; Paul T Schumacker; Navdeep S Chandel
Mitochondria are required for antigen-specific T cell activation through reactive oxygen species signaling.
Robert B Hamanaka; Paul Hoover; Robert M Lavker; Andrew R Mullen; Shuangni Yang; Ralph J DeBerardinis; Spiro Getsios; Andrea Glasauer; Cara J Gottardi; Hanz Blatt; Navdeep S Chandel
Mitochondrial reactive oxygen species promote epidermal differentiation and hair follicle development.

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All Publications

2013: Michael S Schieber; Navdeep S Chandel
ROS links glucose metabolism to breast cancer stem cell and EMT phenotype.
Cancer cell 2013;23(3):265-7.
2013: Laura A Sena; Chyung-Ru Wang; Paul J Bryce; Teresa Ezponda; David A Hildeman; Amit Jairaman; Sha Li; Jonathan D Licht; Harris Perlman; Murali Prakriya; Paul T Schumacker; Navdeep S Chandel
Mitochondria are required for antigen-specific T cell activation through reactive oxygen species signaling.
Immunity 2013;38(2):225-36.
2013: Robert B Hamanaka; Paul Hoover; Robert M Lavker; Andrew R Mullen; Shuangni Yang; Ralph J DeBerardinis; Spiro Getsios; Andrea Glasauer; Cara J Gottardi; Hanz Blatt; Navdeep S Chandel
Mitochondrial reactive oxygen species promote epidermal differentiation and hair follicle development.
Science signaling 2013;6(261):ra8.
2013: Andrea Glasauer; Navdeep S Chandel
ROS.
Current biology : CB 2013;23(3):R100-2.
2013: Manu Jain; Elena A Monclus; Gokhan M Mutlu; Stephanie Rivera; Lauren Synenki; Aaron Zirk; G R Scott Budinger; James Eisenbart; Carol Feghali-Bostwick; Navdeep S Chandel
Mitochondrial reactive oxygen species regulate transforming growth factor-β signaling.
The Journal of biological chemistry 2013;288(2):770-7.
2012: Laura A Sena; Navdeep S Chandel
Physiological roles of mitochondrial reactive oxygen species.
Molecular cell 2012;48(2):158-67.
2012: Lucas B Sullivan; Janine H Santos; Navdeep S Chandel
Mitochondria and telomeres: the promiscuous roles of TIN2.
Molecular cell 2012;47(6):823-4.
2012: Han Peng; Wending Yang; Hanz Blatt; Paul J Bryar; Navdeep S Chandel; Spiro Getsios; Robert B Hamanaka; Liangliang Hao; Randall S Johnson; Nihal Kaplan; Julia Katsnelson; Robert M Lavker
microRNA-31/factor-inhibiting hypoxia-inducible factor 1 nexus regulates keratinocyte differentiation.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(35):14030-4.
2012: Han Peng; Wending Yang; Navdeep S Chandel; Robert B Hamanaka; Liang-Liang Hao; Julia Katsnelson; Robert M Lavker
MicroRNA-31 targets FIH-1 to positively regulate corneal epithelial glycogen metabolism.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2012;26(8):3140-7.
2012: Sang-Min Jeon; Navdeep S Chandel; Nissim Hay
AMPK regulates NADPH homeostasis to promote tumour cell survival during energy stress.
Nature 2012;485(7400):661-5.
2012: Robert B Hamanaka; Navdeep S Chandel
Targeting glucose metabolism for cancer therapy.
The Journal of experimental medicine 2012;209(2):211-5.
2012: Gökhan M Mutlu; Annie Pardo; Stephanie Rivera; Moises Selman; Jacob Iasha Sznajder; Daniela Urich; John Varga; Minghua Wu; Aaron Zirk; G R Scott Budinger; Navdeep S Chandel; Sergio E Chiarella; Asish K Ghosh; Leonard H T Go; David W Kamp; Anna Lam; Manu Jain
Proteasomal inhibition after injury prevents fibrosis by modulating TGF-β(1) signalling.
Thorax 2012;67(2):139-46.
2012: Andrew R Mullen; Lucas B Sullivan; William W Wheaton; Youfeng Yang; Navdeep S Chandel; Pei-Hsuan Chen; Tzuling Cheng; Eunsook S Jin; W Marston Linehan; Ralph J DeBerardinis
Reductive carboxylation supports growth in tumour cells with defective mitochondria.
Nature 2012;481(7381):385-8.
2012: Saul Soberanes; Daniela Urich; Navdeep S Chandel; Sergio E Chiarella; Andrea De Vizcaya-Ruiz; Angel Gonzalez; Joy Joseph; Balaraman Kalyanaraman; Gökhan M Mutlu; Alvaro Roman Osornio-Vargas; Kathryn A Radigan; Karen M Ridge; G R Scott Budinger
Particulate matter Air Pollution induces hypermethylation of the p16 promoter Via a mitochondrial ROS-JNK-DNMT1 pathway.
Scientific reports 2012;2():275.
2012: Laura A Dada; Angel R Gonzalez; Tomas S Manghi; G R Scott Budinger; Navdeep S Chandel; Sergio E Chiarella; Saul Soberanes; Daniela Urich; Gökhan M Mutlu
Alcohol worsens acute lung injury by inhibiting alveolar sodium transport through the adenosine A1 receptor.
PloS one 2012;7(1):e30448.
2011: Robert B Hamanaka; Navdeep S Chandel
Cell biology. Warburg effect and redox balance.
Science (New York, N.Y.) 2011;334(6060):1219-20.
2011: Christine U Vohwinkel; István Vadász; Navdeep S Chandel; Emilia Lecuona; Natascha Sommer; Haying Sun; Jacob I Sznajder
Elevated CO(2) levels cause mitochondrial dysfunction and impair cell proliferation.
The Journal of biological chemistry 2011;286(43):37067-76.
2011: Kathryn V Tormos; Elena Anso; James Eisenbart; Robert B Hamanaka; Joy Joseph; Balaraman Kalyanaraman; Navdeep S Chandel
Mitochondrial complex III ROS regulate adipocyte differentiation.
Cell metabolism 2011;14(4):537-44.
2011: Claudio Mauro; Marta Moretti; Sonia Rocha; Vinay Tergaonkar; Anil K Thotakura; Laura Tornatore; Elena Anso; Amer A Beg; Navdeep S Chandel; enrico de smaele; Shi Chi Leow; Guido Franzoso
NF-κB controls energy homeostasis and metabolic adaptation by upregulating mitochondrial respiration.
Nature cell biology 2011;13(10):1272-9.
2011: Galina A Gusarova; Robert B Hamanaka; Gökhan M Mutlu; Murali Prakriya; Arturo Briva; Navdeep S Chandel; Laura A Dada; Humberto Trejo; Lynn C Welch; Jacob I Sznajder
Hypoxia leads to Na,K-ATPase downregulation via Ca(2+) release-activated Ca(2+) channels and AMPK activation.
Molecular and cellular biology 2011;31(17):3546-56.
2011: Ramanarao Dirisina; Tatiana Goretsky; Rebecca B Katzman; Elizabeth Managlia; Navdha Mittal; Wei Qiu; David B Williams; Jian Yu; Lin Zhang; Navdeep S Chandel; Terrence Anthony Barrett
p53 and PUMA independently regulate apoptosis of intestinal epithelial cells in patients and mice with colitis.
Gastroenterology 2011;141(3):1036-45.
2011: Gabriel Loor; Jyothisri Kondapalli; Hirotaro Iwase; Navdeep S Chandel; Gregory B Waypa; Robert D Guzy; Terry Vanden Hoek; Paul T Schumacker
Mitochondrial oxidant stress triggers cell death in simulated ischemia-reperfusion.
Biochimica et biophysica acta 2011;1813(7):1382-94.
2011: Manu Jain; G R Scott Budinger; Amy Lo; Daniela Urich; Stephanie E Rivera; Asish K Ghosh; Angel Gonzalez; Sergio E Chiarella; Katie Marks; Helen K Donnelly; Saul Soberanes; John Varga; Kathryn A Radigan; Navdeep S Chandel; Gökhan M Mutlu
Leptin promotes fibroproliferative acute respiratory distress syndrome by inhibiting peroxisome proliferator-activated receptor-γ.
American journal of respiratory and critical care medicine 2011;183(11):1490-8.
2011: G R Scott Budinger; Gökhan M Mutlu; Daniela Urich; Saul Soberanes; Leonard J Buccellato; Keenan Hawkins; Sergio E Chiarella; Kathryn A Radigan; James Eisenbart; Hemant Agrawal; Sara Berkelhamer; Siegfried Hekimi; Jianke Zhang; Harris Perlman; Paul T Schumacker; Manu Jain; Navdeep S Chandel
Epithelial cell death is an important contributor to oxidant-mediated acute lung injury.
American journal of respiratory and critical care medicine 2011;183(8):1043-54.
2011: William W Wheaton; Navdeep S Chandel
Hypoxia. 2. Hypoxia regulates cellular metabolism.
American journal of physiology. Cell physiology 2011;300(3):C385-93.
2010: Navdeep S Chandel
Mitochondrial complex III: an essential component of universal oxygen sensing machinery?
Respiratory physiology & neurobiology 2010;174(3):175-81.
2010: Gabriel Loor; Jyothisri Kondapalli; Jacqueline M Schriewer; Navdeep S Chandel; Terry Vanden Hoek; Paul T Schumacker
Menadione triggers cell death through ROS-dependent mechanisms involving PARP activation without requiring apoptosis.
Free radical biology & medicine 2010;49(12):1925-36.
2010: Robert B Hamanaka; Navdeep S Chandel
Mitochondrial reactive oxygen species regulate cellular signaling and dictate biological outcomes.
Trends in biochemical sciences 2010;35(9):505-13.
2010: Frank Weinberg; Robert Hamanaka; William W Wheaton; Samuel Weinberg; Joy Joseph; Marcos Lopez; Balaraman Kalyanaraman; Gökhan M Mutlu; G R Scott Budinger; Navdeep S Chandel
Mitochondrial metabolism and ROS generation are essential for Kras-mediated tumorigenicity.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(19):8788-93.
2010: Kathryn V Tormos; Navdeep S Chandel
Inter-connection between mitochondria and HIFs.
Journal of cellular and molecular medicine 2010;14(4):795-804.
2010: Ni Na; Navdeep S Chandel; Juan Litvan; Karen M Ridge
Mitochondrial reactive oxygen species are required for hypoxia-induced degradation of keratin intermediate filaments.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2010;24(3):799-809.
2010: John scatizzi; Jack Hutcheson; Richard M Pope; Gary S Firestein; Alisa E Koch; Melissa Mavers; Avraham Smason; Hemant Agrawal; G Kenneth Haines; Navdeep S Chandel; Richard S Hotchkiss; Harris Perlman
Bim-Bcl-2 homology 3 mimetic therapy is effective at suppressing inflammatory arthritis through the activation of myeloid cell apoptosis.
Arthritis and rheumatism 2010;62(2):441-51.
2010: Navdeep S Chandel
Mitochondrial regulation of oxygen sensing.
Advances in experimental medicine and biology 2010;661():339-54.
2009: Robert B Hamanaka; Navdeep S Chandel
Mitochondrial reactive oxygen species regulate hypoxic signaling.
Current opinion in cell biology 2009;21(6):894-9.
2009: Frank Weinberg; Navdeep S Chandel
Reactive oxygen species-dependent signaling regulates cancer.
Cellular and molecular life sciences : CMLS 2009;66(23):3663-73.
2009: Colleen M Snyder; Navdeep S Chandel
Mitochondrial regulation of cell survival and death during low-oxygen conditions.
Antioxidants & redox signaling 2009;11(11):2673-83.
2009: Frank Weinberg; Navdeep S Chandel
Mitochondrial metabolism and cancer.
Annals of the New York Academy of Sciences 2009;1177():66-73.
2009: Chris Peers; Navdeep S Chandel; Gabriel G Haddad
Introduction to hypoxia and consequences: from molecule to malady.
Annals of the New York Academy of Sciences 2009;1177():1.
2009: Galina A Gusarova; Laura A Dada; Aileen M Kelly; Chaya Brodie; Lee A Witters; Navdeep S Chandel; Jacob I Sznajder
Alpha1-AMP-activated protein kinase regulates hypoxia-induced Na,K-ATPase endocytosis via direct phosphorylation of protein kinase C zeta.
Molecular and cellular biology 2009;29(13):3455-64.
2009: Daniela Urich; Saul Soberanes; Zach Burgess; Sergio E Chiarella; Andrew J Ghio; Karen M Ridge; David W Kamp; Navdeep S Chandel; Gökhan M Mutlu; G R Scott Budinger
Proapoptotic Noxa is required for particulate matter-induced cell death and lung inflammation.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2009;23(7):2055-64.
2009: Brooke M Emerling; Frank Weinberg; Colleen Snyder; Zach Burgess; Gökhan M Mutlu; Benoit Viollet; G R Scott Budinger; Navdeep S Chandel
Hypoxic activation of AMPK is dependent on mitochondrial ROS but independent of an increase in AMP/ATP ratio.
Free radical biology & medicine 2009;46(10):1386-91.
2009: Navdeep S Chandel; G R Scott Budinger; Gökhan M Mutlu; John Varga; Lauren Synenki; Helen K Donnelly; Aaron Zirk; James Eisenbart; Borko Jovanovic; Manu Jain
Keratinocyte growth factor expression is suppressed in early acute lung injury/acute respiratory distress syndrome by smad and c-Abl pathways.
Critical care medicine 2009;37(5):1678-84.
2009: Tatyana A Klimova; Eric L Bell; Emelyn H Shroff; Frank D Weinberg; Colleen M Snyder; Goberdan P Dimri; Paul T Schumacker; G R Scott Budinger; Navdeep S Chandel
Hyperoxia-induced premature senescence requires p53 and pRb, but not mitochondrial matrix ROS.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2009;23(3):783-94.
2009: Saul Soberanes; Daniela Urich; Christina M Baker; Zach Burgess; Sergio E Chiarella; Eric L Bell; Andrew J Ghio; Andrea De Vizcaya-Ruiz; Jing Liu; Karen M Ridge; David W Kamp; Navdeep S Chandel; Paul T Schumacker; Gökhan M Mutlu; G R Scott Budinger
Mitochondrial complex III-generated oxidants activate ASK1 and JNK to induce alveolar epithelial cell death following exposure to particulate matter air pollution.
The Journal of biological chemistry 2009;284(4):2176-86.
2009: Colleen M Snyder; Emelyn H Shroff; Jing Liu; Navdeep S Chandel
Nitric oxide induces cell death by regulating anti-apoptotic BCL-2 family members.
PloS one 2009;4(9):e7059.
2009: Emelyn H Shroff; Colleen M Snyder; G R Scott Budinger; Manu Jain; Teng-Leong Chew; Satya Khuon; Harris Perlman; Navdeep S Chandel
BH3 peptides induce mitochondrial fission and cell death independent of BAX/BAK.
PloS one 2009;4(5):e5646.
2008: Guofei Zhou; Laura A Dada; Navdeep S Chandel; Kazuhiro Iwai; Emilia Lecuona; Aaron Ciechanover; Jacob I Sznajder
Hypoxia-mediated Na-K-ATPase degradation requires von Hippel Lindau protein.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2008;22(5):1335-42.
2008: T Klimova; Navdeep S Chandel
Mitochondrial complex III regulates hypoxic activation of HIF.
Cell death and differentiation 2008;15(4):660-6.
2008: Eric L Bell; Tatyana Klimova; Navdeep S Chandel
Targeting the mitochondria for cancer therapy: regulation of hypoxia-inducible factor by mitochondria.
Antioxidants & redox signaling 2008;10(3):635-40.
2008: Brooke M Emerling; Frank Weinberg; Juinn-Lin Liu; Tak W Mak; Navdeep S Chandel
PTEN regulates p300-dependent hypoxia-inducible factor 1 transcriptional activity through Forkhead transcription factor 3a (FOXO3a).
Proceedings of the National Academy of Sciences of the United States of America 2008;105(7):2622-7.
2008: István Vadász; Laura A Dada; Arturo Briva; Humberto Trejo; Lynn C Welch; Jiwang Chen; Péter T Tóth; Emilia Lecuona; Lee A Witters; Paul T Schumacker; Navdeep S Chandel; Werner Seeger; Jacob I Sznajder
AMP-activated protein kinase regulates CO2-induced alveolar epithelial dysfunction in rats and human cells by promoting Na,K-ATPase endocytosis.
The Journal of clinical investigation 2008;118(2):752-62.
2008: Xiaoyu Lin; Caroline A David; Jennifer B Donnelly; Mike Michaelides; Navdeep S Chandel; Xiaoli Huang; Usha Warrior; Frank Weinberg; Kathryn V Tormos; Stephen W Fesik; Yu Shen
A chemical genomics screen highlights the essential role of mitochondria in HIF-1 regulation.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(1):174-9.
2008: Robert D Guzy; Bhumika Sharma; Eric Bell; Navdeep S Chandel; Paul T Schumacker
Loss of the SdhB, but Not the SdhA, subunit of complex II triggers reactive oxygen species-dependent hypoxia-inducible factor activation and tumorigenesis.
Molecular and cellular biology 2008;28(2):718-31.
2007: Brooke M Emerling; Benoit Viollet; Kathryn V Tormos; Navdeep S Chandel
Compound C inhibits hypoxic activation of HIF-1 independent of AMPK.
FEBS letters 2007;581(29):5727-31.
2007: Gökhan M Mutlu; David Green; Amy Bellmeyer; Christina M Baker; Zach Burgess; Nalini Rajamannan; John W Christman; Nancy Foiles; David W Kamp; Andrew J Ghio; Navdeep S Chandel; David A Dean; Jacob I Sznajder; G R Scott Budinger
Ambient particulate matter accelerates coagulation via an IL-6-dependent pathway.
The Journal of clinical investigation 2007;117(10):2952-61.
2007: Emelyn H Shroff; Colleen Snyder; Navdeep S Chandel
Bcl-2 family members regulate anoxia-induced cell death.
Antioxidants & redox signaling 2007;9(9):1405-9.
2007: Hirotaro Iwase; Emmanuel Robin; Robert D Guzy; Paul T Mungai; Terry Vanden Hoek; Navdeep S Chandel; Jacques Levraut; Paul T Schumacker
Nitric oxide during ischemia attenuates oxidant stress and cell death during ischemia and reperfusion in cardiomyocytes.
Free radical biology & medicine 2007;43(4):590-9.
2007: Helena L Wang; Ibrahim Ozkan Akinci; Christina M Baker; Daniela Urich; Amy Bellmeyer; Manu Jain; Navdeep S Chandel; Gökhan M Mutlu; G R Scott Budinger
The intrinsic apoptotic pathway is required for lipopolysaccharide-induced lung endothelial cell death.
Journal of immunology (Baltimore, Md. : 1950) 2007;179(3):1834-41.
2007: Eric L Bell; Tatyana A Klimova; James Eisenbart; Paul T Schumacker; Navdeep S Chandel
Mitochondrial reactive oxygen species trigger hypoxia-inducible factor-dependent extension of the replicative life span during hypoxia.
Molecular and cellular biology 2007;27(16):5737-45.
2007: Eric L Bell; Tatyana A Klimova; James Eisenbart; Carlos T Moraes; Michael P Murphy; G R Scott Budinger; Navdeep S Chandel
The Qo site of the mitochondrial complex III is required for the transduction of hypoxic signaling via reactive oxygen species production.
The Journal of cell biology 2007;177(6):1029-36.
2007: Emelyn H Shroff; Colleen Snyder; Navdeep S Chandel
Role of Bcl-2 family members in anoxia induced cell death.
Cell cycle (Georgetown, Tex.) 2007;6(7):807-9.
2007: Amy Bellmeyer; Janice M Martino; Navdeep S Chandel; G R Scott Budinger; David A Dean; Gökhan M Mutlu
Leptin resistance protects mice from hyperoxia-induced acute lung injury.
American journal of respiratory and critical care medicine 2007;175(6):587-94.
2007: Lauren Synenki; Navdeep S Chandel; G R Scott Budinger; Helen K Donnelly; Jeremy Topin; James Eisenbart; Borko Jovanovic; Manu Jain
Bronchoalveolar lavage fluid from patients with acute lung injury/acute respiratory distress syndrome induces myofibroblast differentiation.
Critical care medicine 2007;35(3):842-8.
2007: Ram M Subramanian; Navdeep S Chandel; G R Scott Budinger; Paul T Schumacker
Hypoxic conformance of metabolism in primary rat hepatocytes: a model of hepatic hibernation.
Hepatology (Baltimore, Md.) 2007;45(2):455-64.
2007: Joslyn K Brunelle; Emelyn H Shroff; Harris Perlman; Andreas Strasser; Carlos T Moraes; Richard A Flavell; Nika N Danial; Brian Keith; Craig Thompson; Navdeep S Chandel
Loss of Mcl-1 protein and inhibition of electron transport chain together induce anoxic cell death.
Molecular and cellular biology 2007;27(4):1222-35.
2007: Navdeep S Chandel; G R Scott Budinger
The cellular basis for diverse responses to oxygen.
Free radical biology & medicine 2007;42(2):165-74.
2007: Eric L Bell; Navdeep S Chandel
Genetics of mitochondrial electron transport chain in regulating oxygen sensing.
Methods in enzymology 2007;435():447-61.
2007: Eric L Bell; Navdeep S Chandel
Mitochondrial oxygen sensing: regulation of hypoxia-inducible factor by mitochondrial generated reactive oxygen species.
Essays in biochemistry 2007;43():17-27.
2006: Gökhan M Mutlu; Colleen Snyder; Amy Bellmeyer; Helena Wang; Keenan Hawkins; Saul Soberanes; Lynn C Welch; Andrew J Ghio; Navdeep S Chandel; David W Kamp; Jacob I Sznajder; G R Scott Budinger
Airborne particulate matter inhibits alveolar fluid reabsorption in mice via oxidant generation.
American journal of respiratory cell and molecular biology 2006;34(6):670-6.
2006: Alejandro P Comellas; Laura A Dada; Emilia Lecuona; Liuska Pesce; Navdeep S Chandel; Nancy Quesada; G R Scott Budinger; Ger J Strous; Aaron Ciechanover; Jacob I Sznajder
Hypoxia-mediated degradation of Na,K-ATPase via mitochondrial reactive oxygen species and the ubiquitin-conjugating system.
Circulation research 2006;98(10):1314-22.
2006: Vijayalakshmi Panduri; Sailesh Surapureddi; Saul Soberanes; Sigmund A Weitzman; Navdeep S Chandel; David W Kamp
P53 mediates amosite asbestos-induced alveolar epithelial cell mitochondria-regulated apoptosis.
American journal of respiratory cell and molecular biology 2006;34(4):443-52.
2006: G R Scott Budinger; Gökhan M Mutlu; James Eisenbart; Alyson C Fuller; Amy Bellmeyer; Christina M Baker; Mindy Wilson; Karen M Ridge; Terrence Anthony Barrett; Vivian Y Lee; Navdeep S Chandel
Proapoptotic Bid is required for pulmonary fibrosis.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(12):4604-9.
2005: Joan S Lewis; Kathleen Meeke; Clodia Osipo; Eric A Ross; Noman Kidawi; Tianyu Li; Eric Bell; Navdeep S Chandel; V Craig Jordan
Intrinsic mechanism of estradiol-induced apoptosis in breast cancer cells resistant to estrogen deprivation.
Journal of the National Cancer Institute 2005;97(23):1746-59.
2005: Vivian Y Lee; Clara Schroedl; Joslyn K Brunelle; Leonard J Buccellato; Ibrahim Ozkan Akinci; Hideaki Kaneto; Colleen Snyder; James Eisenbart; G R Scott Budinger; Navdeep S Chandel
Bleomycin induces alveolar epithelial cell death through JNK-dependent activation of the mitochondrial death pathway.
American journal of physiology. Lung cellular and molecular physiology 2005;289(4):L521-8.
2005: Eric L Bell; Brooke M Emerling; Navdeep S Chandel
Mitochondrial regulation of oxygen sensing.
Mitochondrion 2005;5(5):322-32.
2005: Brooke M Emerling; Navdeep S Chandel
Oxygen sensing: getting pumped by sterols.
Science's STKE : signal transduction knowledge environment 2005;2005(289):pe30.
2005: Joslyn K Brunelle; Eric L Bell; Nancy M Quesada; Kristel Vercauteren; Valeria Tiranti; Massimo Zeviani; Richard C Scarpulla; Navdeep S Chandel
Oxygen sensing requires mitochondrial ROS but not oxidative phosphorylation.
Cell metabolism 2005;1(6):409-14.
2005: Brooke M Emerling; Leonidas C Platanias; Emma Black; Angel R Nebreda; Roger J Davis; Navdeep S Chandel
Mitochondrial reactive oxygen species activation of p38 mitogen-activated protein kinase is required for hypoxia signaling.
Molecular and cellular biology 2005;25(12):4853-62.
2005: G R Scott Budinger; Navdeep S Chandel; Helen K Donnelly; James Eisenbart; Monica Oberoi; Manu Jain
Active transforming growth factor-beta1 activates the procollagen I promoter in patients with acute lung injury.
Intensive care medicine 2005;31(1):121-8.
2004: Nathan Majewski; Veronique Nogueira; Prashanth T Bhaskar; Platina E Coy; Jennifer E Skeen; Kathrin Gottlob; Navdeep S Chandel; Craig Thompson; R Brooks Robey; Nissim Hay
Hexokinase-mitochondria interaction mediated by Akt is required to inhibit apoptosis in the presence or absence of Bax and Bak.
Molecular cell 2004;16(5):819-30.
2004: Vijayalakshmi Panduri; Sigmund A Weitzman; Navdeep S Chandel; David W Kamp
Mitochondrial-derived free radicals mediate asbestos-induced alveolar epithelial cell apoptosis.
American journal of physiology. Lung cellular and molecular physiology 2004;286(6):L1220-7.
2004: Hena Alam; Evelyn T Maizels; Youngkyu Park; Shail Ghaey; Zachary J Feiger; Navdeep S Chandel; Mary Hunzicker-Dunn
Follicle-stimulating hormone activation of hypoxia-inducible factor-1 by the phosphatidylinositol 3-kinase/AKT/Ras homolog enriched in brain (Rheb)/mammalian target of rapamycin (mTOR) pathway is necessary for induction of select protein markers of follicular differentiation.
The Journal of biological chemistry 2004;279(19):19431-40.
2004: Leonard J Buccellato; May Tso; Ibrahim Ozkan Akinci; Navdeep S Chandel; G R Scott Budinger
Reactive oxygen species are required for hyperoxia-induced Bax activation and cell death in alveolar epithelial cells.
The Journal of biological chemistry 2004;279(8):6753-60.
2004: Joslyn K Brunelle; Matthew T Santore; G R Scott Budinger; Yueming Tang; Terrence Anthony Barrett; Wei-Xing Zong; Eugene Kandel; Brian Keith; M Celeste Simon; Craig Thompson; Nissim Hay; Navdeep S Chandel
c-Myc sensitization to oxygen deprivation-induced cell death is dependent on Bax/Bak, but is independent of p53 and hypoxia-inducible factor-1.
The Journal of biological chemistry 2004;279(6):4305-12.
2003: Holly Anne Hanford; Christie A Wong; Hallie Kassan; Deborah L Cundiff; Navdeep S Chandel; Suzanne Underwood; Christopher A Mitchell; Gerald A Soff
Angiostatin(4.5)-mediated apoptosis of vascular endothelial cells.
Cancer research 2003;63(14):4275-80.
2003: Laura A Dada; Navdeep S Chandel; Karen M Ridge; Carlos Pedemonte; Alejandro M Bertorello; Jacob I Sznajder
Hypoxia-induced endocytosis of Na,K-ATPase in alveolar epithelial cells is mediated by mitochondrial reactive oxygen species and PKC-zeta.
The Journal of clinical investigation 2003;111(7):1057-64.
2003: Vijayalakshmi Panduri; Sigmund A Weitzman; Navdeep S Chandel; David W Kamp
The mitochondria-regulated death pathway mediates asbestos-induced alveolar epithelial cell apoptosis.
American journal of respiratory cell and molecular biology 2003;28(2):241-8.
2002: Joslyn K Brunelle; Navdeep S Chandel
Oxygen deprivation induced cell death: an update.
Apoptosis : an international journal on programmed cell death 2002;7(6):475-82.
2002: Clara Schroedl; David S McClintock; G R Scott Budinger; Navdeep S Chandel
Hypoxic but not anoxic stabilization of HIF-1alpha requires mitochondrial reactive oxygen species.
American journal of physiology. Lung cellular and molecular physiology 2002;283(5):L922-31.
2002: Andre Kulisz; Ningfang Chen; Navdeep S Chandel; Zuohui Shao; Paul T Schumacker
Mitochondrial ROS initiate phosphorylation of p38 MAP kinase during hypoxia in cardiomyocytes.
American journal of physiology. Lung cellular and molecular physiology 2002;282(6):L1324-9.
2002: G R Scott Budinger; May Tso; David S McClintock; David A Dean; Jacob I Sznajder; Navdeep S Chandel
Hyperoxia-induced apoptosis does not require mitochondrial reactive oxygen species and is regulated by Bcl-2 proteins.
The Journal of biological chemistry 2002;277(18):15654-60.
2002: Vivian Y Lee; David S McClintock; Matthew T Santore; G R Scott Budinger; Navdeep S Chandel
Hypoxia sensitizes cells to nitric oxide-induced apoptosis.
The Journal of biological chemistry 2002;277(18):16067-74.
2002: David W Kamp; Vijayalakshmi Panduri; Sigmund A Weitzman; Navdeep S Chandel
Asbestos-induced alveolar epithelial cell apoptosis: role of mitochondrial dysfunction caused by iron-derived free radicals.
Molecular and cellular biochemistry 2002;234-235(1-2):153-60.
2002: Matthew T Santore; David S McClintock; Vivian Y Lee; G R Scott Budinger; Navdeep S Chandel
Anoxia-induced apoptosis occurs through a mitochondria-dependent pathway in lung epithelial cells.
American journal of physiology. Lung cellular and molecular physiology 2002;282(4):L727-34.
2002: Navdeep S Chandel
Detection of oxygen-sensing properties of mitochondria.
Methods in enzymology 2002;352():31-40.
2002: David S McClintock; Matthew T Santore; Vivian Y Lee; Joslyn K Brunelle; G R Scott Budinger; Wei-Xing Zong; Craig Thompson; Nissim Hay; Navdeep S Chandel
Bcl-2 family members and functional electron transport chain regulate oxygen deprivation-induced cell death.
Molecular and cellular biology 2002;22(1):94-104.
2001: Navdeep S Chandel; Paul T Schumacker; RH Arch
Reactive oxygen species are downstream products of TRAF-mediated signal transduction.
The Journal of biological chemistry 2001;276(46):42728-36.
2001: Gregory B Waypa; Navdeep S Chandel; Paul T Schumacker
Model for hypoxic pulmonary vasoconstriction involving mitochondrial oxygen sensing.
Circulation research 2001;88(12):1259-66.
2001: G R Scott Budinger; Navdeep S Chandel
The role of cell suicide or apoptosis in the pathophysiology of acute lung injury.
Intensive care medicine 2001;27(6):1091-3.
2000: Navdeep S Chandel; David S McClintock; C E Feliciano; T M Wood; J Andres Melendez; Ana M Rodriguez; Paul T Schumacker
Reactive oxygen species generated at mitochondrial complex III stabilize hypoxia-inducible factor-1alpha during hypoxia: a mechanism of O2 sensing.
The Journal of biological chemistry 2000;275(33):25130-8.
2000: Navdeep S Chandel; Matthew G Vander Heiden; Craig Thompson; Paul T Schumacker
Redox regulation of p53 during hypoxia.
Oncogene 2000;19(34):3840-8.
2000: Navdeep S Chandel; W C Trzyna; David S McClintock; Paul T Schumacker
Role of oxidants in NF-kappa B activation and TNF-alpha gene transcription induced by hypoxia and endotoxin.
Journal of immunology (Baltimore, Md. : 1950) 2000;165(2):1013-21.
2000: Matthew G Vander Heiden; Navdeep S Chandel; X X Li; Paul T Schumacker; Marco Colombini; Craig Thompson
Outer mitochondrial membrane permeability can regulate coupled respiration and cell survival.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(9):4666-71.
1999: Mir H Ali; S A Schlidt; Navdeep S Chandel; Karen L Hynes; Paul T Schumacker; Bruce Gewertz
Endothelial permeability and IL-6 production during hypoxia: role of ROS in signal transduction.
The American journal of physiology 1999;277(5 Pt 1):L1057-65.
1999: Navdeep S Chandel; P T Schumacker
Cells depleted of mitochondrial DNA (rho0) yield insight into physiological mechanisms.
FEBS letters 1999;454(3):173-6.
1999: Matthew G Vander Heiden; Navdeep S Chandel; Paul T Schumacker; Craig Thompson
Bcl-xL prevents cell death following growth factor withdrawal by facilitating mitochondrial ATP/ADP exchange.
Molecular cell 1999;3(2):159-67.
1999: Craig Thompson; Jeffrey C Rathmell; Kenneth A Frauwirth; Tullia Lindsten; Charles Rudin; Joseph T Opferman; Philip G Ashton-Rickardt; Marian H Harris; Navdeep S Chandel; Paul T Schumacker; Matthew G Vander Heiden
What keeps a resting T cell alive?
Cold Spring Harbor symposia on quantitative biology 1999;64():383-7.
1998: Navdeep S Chandel; Emin Maltepe; E Goldwasser; C E Mathieu; M Celeste Simon; Paul T Schumacker
Mitochondrial reactive oxygen species trigger hypoxia-induced transcription.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(20):11715-20.
1998: J Duranteau; Navdeep S Chandel; Andre Kulisz; Zuohui Shao; Paul T Schumacker
Intracellular signaling by reactive oxygen species during hypoxia in cardiomyocytes.
The Journal of biological chemistry 1998;273(19):11619-24.
1998: G R Scott Budinger; J Duranteau; Navdeep S Chandel; Paul T Schumacker
Hibernation during hypoxia in cardiomyocytes. Role of mitochondria as the O2 sensor.
The Journal of biological chemistry 1998;273(6):3320-6.
1997: Matthew G Vander Heiden; Navdeep S Chandel; Edward K Williamson; Paul T Schumacker; Craig Thompson
Bcl-xL regulates the membrane potential and volume homeostasis of mitochondria.
Cell 1997;91(5):627-37.
1997: Navdeep S Chandel; G R Scott Budinger; S H Choe; Paul T Schumacker
Cellular respiration during hypoxia. Role of cytochrome oxidase as the oxygen sensor in hepatocytes.
The Journal of biological chemistry 1997;272(30):18808-16.
1996: Navdeep S Chandel; G R Scott Budinger; Paul T Schumacker
Molecular oxygen modulates cytochrome c oxidase function.
The Journal of biological chemistry 1996;271(31):18672-7.
1996: G R Scott Budinger; Navdeep S Chandel; Zuo-Hui Shao; Chang-Qing Li; A Melmed; Lance B Becker; Paul T Schumacker
Cellular energy utilization and supply during hypoxia in embryonic cardiac myocytes.
The American journal of physiology 1996;270(1 Pt 1):L44-53.
1995: Navdeep S Chandel; G R Scott Budinger; R A Kemp; Paul T Schumacker
Inhibition of cytochrome-c oxidase activity during prolonged hypoxia.
The American journal of physiology 1995;268(6 Pt 1):L918-25.
1993: Paul T Schumacker; Navdeep S Chandel; A G Agusti
Oxygen conformance of cellular respiration in hepatocytes.
The American journal of physiology 1993;265(4 Pt 1):L395-402.