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Visvanathan Chandramouli

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Physiology

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Glucose Clamp Technique

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Ilya R Bederman; Visvanathan Chandramouli; Leigh Henderson; Yana Sandlers; Marco E Cabrera
Time course of hepatic gluconeogenesis during hindlimb suspension unloading.
Hsuan-Ming Huang; Faramarz Ismail-Beigi; Visvanathan Chandramouli; Raymond F Muzic
Hyperglycemia-induced stimulation of glucose transport in skeletal muscle measured by PET-[18F]6FDG and [18F]2FDG.
Raymond F Muzic; Yanming Wang; Chunying Wu; Visvanathan Chandramouli; Hsuan-Ming Huang; Faramarz Ismail-Beigi
Analysis of metabolism of 6FDG: a PET glucose transport tracer.

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All Publications

2013: Ilya R Bederman; Visvanathan Chandramouli; Leigh Henderson; Yana Sandlers; Marco E Cabrera
Time course of hepatic gluconeogenesis during hindlimb suspension unloading.
Experimental physiology 2013;98(1):278-89.
2012: Hsuan-Ming Huang; Faramarz Ismail-Beigi; Visvanathan Chandramouli; Raymond F Muzic
Hyperglycemia-induced stimulation of glucose transport in skeletal muscle measured by PET-[18F]6FDG and [18F]2FDG.
Physiological measurement 2012;33(10):1661-73.
2011: Raymond F Muzic; Yanming Wang; Chunying Wu; Visvanathan Chandramouli; Hsuan-Ming Huang; Faramarz Ismail-Beigi
Analysis of metabolism of 6FDG: a PET glucose transport tracer.
Nuclear medicine and biology 2011;38(5):667-74.
2011: Michaela Kacerovsky; John Jones; Albrecht I Schmid; Cristina Barosa; Angelika Lettner; Gertrud Kacerovsky-Bielesz; Julia Szendroedi; Marek Chmelik; Peter Nowotny; Visvanathan Chandramouli; Michael Wolzt; Michael Roden
Postprandial and fasting hepatic glucose fluxes in long-standing type 1 diabetes.
Diabetes 2011;60(6):1752-8.
2009: Sylvia Kehlenbrink; Julia Tonelli; Sudha Koppaka; Visvanathan Chandramouli; Meredith Hawkins; Preeti Kishore
Inhibiting gluconeogenesis prevents fatty acid-induced increases in endogenous glucose production.
American journal of physiology. Endocrinology and metabolism 2009;297(1):E165-73.
2009: Chandra Spring-Robinson; Visvanathan Chandramouli; William C Schumann; Peter F Faulhaber; Yanming Wang; Chunying Wu; Faramarz Ismail-Beigi; Raymond F Muzic
Uptake of 18F-labeled 6-fluoro-6-deoxy-D-glucose by skeletal muscle is responsive to insulin stimulation.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2009;50(6):912-9.
2009: Ilya R Bederman; Steven Foy; Visvanathan Chandramouli; James C Alexander; Stephen Previs
Triglyceride synthesis in epididymal adipose tissue: contribution of glucose and non-glucose carbon sources.
The Journal of biological chemistry 2009;284(10):6101-8.
2008: Rita Basu; Ananda Basu; Visvanathan Chandramouli; B Norby; Betty Dicke; Pankaj Shah; O Cohen; Bernard R Landau; Robert A Rizza
Effects of pioglitazone and metformin on NEFA-induced insulin resistance in type 2 diabetes.
Diabetologia 2008;51(11):2031-40.
2008: Rita Basu; Visvanathan Chandramouli; Betty Dicke; Bernard R Landau; Robert A Rizza
Plasma C5 glucose-to-2H2O ratio does not provide an accurate assessment of gluconeogenesis during hyperinsulinemic-euglycemic clamps in either nondiabetic or diabetic humans.
Diabetes 2008;57(7):1800-4.
2008: Charlotte Höybye; Visvanathan Chandramouli; Suad Efendic; Anna-Lena Hulting; Bernard R Landau; William C Schumann; A Wajngot
Contribution of gluconeogenesis and glycogenolysis to hepatic glucose production in acromegaly before and after pituitary microsurgery.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et métabolisme 2008;40(7):498-501.
2008: Shawn C Burgess; Visvanathan Chandramouli; Jeffrey D Browning; William C Schumann; Stephen Previs
Complicating factors in the application of the "average method" for determining the contribution of gluconeogenesis.
Journal of applied physiology (Bethesda, Md. : 1985) 2008;104(6):1852-3; author reply 1854-5.
2008: Gerlies Bock; William C Schumann; Rita Basu; Shawn C Burgess; Zheng Yan; Visvanathan Chandramouli; Robert A Rizza; Bernard R Landau
Evidence that processes other than gluconeogenesis may influence the ratio of deuterium on the fifth and third carbons of glucose: implications for the use of 2H2O to measure gluconeogenesis in humans.
Diabetes 2008;57(1):50-5.
2008: Rita Basu; Pankaj Shah; Ananda Basu; Barbara Norby; Betty Dicke; Visvanathan Chandramouli; Ohad Cohen; Bernard R Landau; Robert A Rizza
Comparison of the effects of pioglitazone and metformin on hepatic and extra-hepatic insulin action in people with type 2 diabetes.
Diabetes 2008;57(1):24-31.
2007: Martin O. Weickert; Christian V Loeffelholz; Michael Roden; Visvanathan Chandramouli; Attila Brehm; Peter Nowotny; Martin Osterhoff; Frank Isken; Joachim Spranger; Bernard R Landau; Andreas F H Pfeiffer; Matthias Möhlig
A Thr94Ala mutation in human liver fatty acid-binding protein contributes to reduced hepatic glycogenolysis and blunted elevation of plasma glucose levels in lipid-exposed subjects.
American journal of physiology. Endocrinology and metabolism 2007;293(4):E1078-84.
2007: Bernard R Landau; Chandra L Spring-Robinson; Raymond F Muzic; Nadia Rachdaoui; Darrell Rubin; Marc S Berridge; William C Schumann; Visvanathan Chandramouli; Timothy S Kern; Faramarz Ismail-Beigi
6-Fluoro-6-deoxy-D-glucose as a tracer of glucose transport.
American journal of physiology. Endocrinology and metabolism 2007;293(1):E237-45.
2007: Yu Kuang; Nicolas Salem; Fangjing Wang; Steve J Schomisch; Visvanathan Chandramouli; Zhenghong Lee
A colorimetric assay method to measure acetyl-CoA synthetase activity: application to woodchuck model of hepatitis virus-induced hepatocellular carcinoma.
Journal of biochemical and biophysical methods 2007;70(4):649-55.
2007: Gerlies Bock; Elizabeth Chittilapilly; Rita Basu; Gianna Toffolo; Claudio Cobelli; Visvanathan Chandramouli; Bernard R Landau; Robert A Rizza
Contribution of hepatic and extrahepatic insulin resistance to the pathogenesis of impaired fasting glucose: role of increased rates of gluconeogenesis.
Diabetes 2007;56(6):1703-11.
2007: Peter Staehr; Ole Hother-Nielsen; Henning Beck-Nielsen; Michael Roden; Harald Stingl; Jens J Holst; Paul K Jones; Visvanathan Chandramouli; Bernard R Landau
Hepatic autoregulation: response of glucose production and gluconeogenesis to increased glycogenolysis.
American journal of physiology. Endocrinology and metabolism 2007;292(5):E1265-9.
2006: Paul D Van Poelje; Scott C Potter; Visvanathan Chandramouli; Bernard R Landau; Qun Dang; Mark D Erion
Inhibition of fructose 1,6-bisphosphatase reduces excessive endogenous glucose production and attenuates hyperglycemia in Zucker diabetic fatty rats.
Diabetes 2006;55(6):1747-54.
2006: Yu Kuang; Steve J Schomisch; Visvanathan Chandramouli; Zhenghong Lee
Hexokinase and glucose-6-phosphatase activity in woodchuck model of hepatitis virus-induced hepatocellular carcinoma.
Comparative biochemistry and physiology. Toxicology & pharmacology : CBP 2006;143(2):225-31.
2006: Harald Stingl; Visvanathan Chandramouli; William C Schumann; Attila Brehm; Peter Nowotny; Werner Waldhäusl; Bernard R Landau; Michael Roden
Changes in hepatic glycogen cycling during a glucose load in healthy humans.
Diabetologia 2006;49(2):360-8.
2005: Rita Basu; Visvanathan Chandramouli; Betty Dicke; Bernard R Landau; Robert A Rizza
Obesity and type 2 diabetes impair insulin-induced suppression of glycogenolysis as well as gluconeogenesis.
Diabetes 2005;54(7):1942-8.
2005: Michael F Nielsen; Andrea Caumo; Niels Kristian Aagaard; Visvanathan Chandramouli; William C Schumann; Bernard R Landau; Ole Schmitz; Hendrik Vilstrup
Contribution of defects in glucose uptake to carbohydrate intolerance in liver cirrhosis: assessment during physiological glucose and insulin concentrations.
American journal of physiology. Gastrointestinal and liver physiology 2005;288(6):G1135-43.
2004: Kristine B Degn; Claus Juhl; Jeppe Sturis; Grethe Jakobsen; Birgitte Brock; Visvanathan Chandramouli; Jørgen Rungby; Bernard R Landau; Ole Schmitz
One week's treatment with the long-acting glucagon-like peptide 1 derivative liraglutide (NN2211) markedly improves 24-h glycemia and alpha- and beta-cell function and reduces endogenous glucose release in patients with type 2 diabetes.
Diabetes 2004;53(5):1187-94.
2004: Stephen Previs; Richard Fatica; Visvanathan Chandramouli; James C Alexander; Henri Brunengraber; Bernard R Landau
Quantifying rates of protein synthesis in humans by use of 2H2O: application to patients with end-stage renal disease.
American journal of physiology. Endocrinology and metabolism 2004;286(4):E665-72.
2004: Michael F Nielsen; Andrea Caumo; Visvanathan Chandramouli; William C Schumann; Claudio Cobelli; Bernard R Landau; Hendrik Vilstrup; Robert A Rizza; Ole Schmitz
Impaired basal glucose effectiveness but unaltered fasting glucose release and gluconeogenesis during short-term hypercortisolemia in healthy subjects.
American journal of physiology. Endocrinology and metabolism 2004;286(1):E102-10.
2003: Olaf Kunert; Harald Stingl; E Rosian; Martin Krssák; Elisabeth Bernroider; Werner Seebacher; Klaus Zangger; Peter Staehr; Visvanathan Chandramouli; Bernard R Landau; Peter Nowotny; Werner Waldhäusl; Ernst Haslinger; Michael Roden
Measurement of fractional whole-body gluconeogenesis in humans from blood samples using 2H nuclear magnetic resonance spectroscopy.
Diabetes 2003;52(10):2475-82.
2003: Daniel Z Brunengraber; Brendan J McCabe; Takhar Kasumov; James C Alexander; Visvanathan Chandramouli; Stephen Previs
Influence of diet on the modeling of adipose tissue triglycerides during growth.
American journal of physiology. Endocrinology and metabolism 2003;285(4):E917-25.
2003: Shawn C Burgess; Merrill Nuss; Visvanathan Chandramouli; Dana S Hardin; Mark Rice; Bernard R Landau; Craig R Malloy; A Dean Sherry
Analysis of gluconeogenic pathways in vivo by distribution of 2H in plasma glucose: comparison of nuclear magnetic resonance and mass spectrometry.
Analytical biochemistry 2003;318(2):321-4.
2003: Michael Krebs; Attila Brehm; Martin Krssak; Christian Anderwald; Elisabeth Bernroider; Peter Nowotny; Erich Roth; Visvanathan Chandramouli; Bernard R Landau; Werner Waldhäusl; Michael Roden
Direct and indirect effects of amino acids on hepatic glucose metabolism in humans.
Diabetologia 2003;46(7):917-25.
2003: Jill Katanik; Brendan J McCabe; Daniel Z Brunengraber; Visvanathan Chandramouli; Fumie J Nishiyama; Vernon E Anderson; Stephen Previs
Measuring gluconeogenesis using a low dose of 2H2O: advantage of isotope fractionation during gas chromatography.
American journal of physiology. Endocrinology and metabolism 2003;284(5):E1043-8.
2003: Peter Staehr; Ole Hother-Nielsen; Bernard R Landau; Visvanathan Chandramouli; Jens Juul Holst; Henning Beck-Nielsen
Effects of free fatty acids per se on glucose production, gluconeogenesis, and glycogenolysis.
Diabetes 2003;52(2):260-7.
2001: Michael D Jensen; Visvanathan Chandramouli; William C Schumann; Karin Ekberg; Stephen Previs; S Gupta; Bernard R Landau
Sources of blood glycerol during fasting.
American journal of physiology. Endocrinology and metabolism 2001;281(5):E998-1004.
2001: William C Schumann; Amalia Gastaldelli; Visvanathan Chandramouli; Stephen Previs; Maura Pettiti; Ele Ferrannini; Bernard R Landau
Determination of the enrichment of the hydrogen bound to carbon 5 of glucose on 2H2O administration.
Analytical biochemistry 2001;297(2):195-7.
2001: Dale S Edgerton; Sylvain Cardin; Maya Emshwiller; Doss Neal; Visvanathan Chandramouli; William C Schumann; Bernard R Landau; L Rossetti; Alan D Cherrington
Small increases in insulin inhibit hepatic glucose production solely caused by an effect on glycogen metabolism.
Diabetes 2001;50(8):1872-82.
2001: A Wajngot; Visvanathan Chandramouli; William C Schumann; Karin Ekberg; P K Jones; Suad Efendic; Bernard R Landau
Quantitative contributions of gluconeogenesis to glucose production during fasting in type 2 diabetes mellitus.
Metabolism: clinical and experimental 2001;50(1):47-52.
2000: Michael F Nielsen; Birgit Nyholm; Andrea Caumo; Visvanathan Chandramouli; William C Schumann; Claudio Cobelli; Bernard R Landau; Robert A Rizza; Ole Schmitz
Prandial glucose effectiveness and fasting gluconeogenesis in insulin-resistant first-degree relatives of patients with type 2 diabetes.
Diabetes 2000;49(12):2135-41.
2000: Ripudaman S Hundal; Martin Krssak; Sylvie Dufour; Didier Laurent; Vincent Lebon; Visvanathan Chandramouli; Silvio E Inzucchi; William C Schumann; Kitt Falk Petersen; Bernard R Landau; Gerald I Shulman
Mechanism by which metformin reduces glucose production in type 2 diabetes.
Diabetes 2000;49(12):2063-9.
2000: A Wajngot; Visvanathan Chandramouli; William C Schumann; Henri Brunengraber; Suad Efendic; Bernard R Landau
A probing dose of phenylacetate does not affect glucose production and gluconeogenesis in humans.
Metabolism: clinical and experimental 2000;49(9):1211-4.
2000: Michael Roden; Harald Stingl; Visvanathan Chandramouli; William C Schumann; Astrid Hofer; Bernard R Landau; Peter Nowotny; Werner Waldhäusl; Gerald I Shulman
Effects of free fatty acid elevation on postabsorptive endogenous glucose production and gluconeogenesis in humans.
Diabetes 2000;49(5):701-7.
1999: Visvanathan Chandramouli; Karin Ekberg; William C Schumann; J Wahren; Bernard R Landau
Origins of the hydrogen bound to carbon 1 of glucose in fasting: significance in gluconeogenesis quantitation.
The American journal of physiology 1999;277(4 Pt 1):E717-23.
1999: Kitt Falk Petersen; Martin Krssak; V Navarro; Visvanathan Chandramouli; Ripudaman S Hundal; William C Schumann; Bernard R Landau; Gerald I Shulman
Contributions of net hepatic glycogenolysis and gluconeogenesis to glucose production in cirrhosis.
The American journal of physiology 1999;276(3 Pt 1):E529-35.
1999: Karin Ekberg; Bernard R Landau; A Wajngot; Visvanathan Chandramouli; Suad Efendic; Henri Brunengraber; J Wahren
Contributions by kidney and liver to glucose production in the postabsorptive state and after 60 h of fasting.
Diabetes 1999;48(2):292-8.
1997: Visvanathan Chandramouli; Karin Ekberg; William C Schumann; Satish C Kalhan; J Wahren; Bernard R Landau
Quantifying gluconeogenesis during fasting.
The American journal of physiology 1997;273(6 Pt 1):E1209-15.
1997: Evelien Dekker; Johannes A Romijn; Karin Ekberg; J Wahren; Huynh van Thien; Mariëtte T Ackermans; L T Thuy; Visvanathan Chandramouli; Piet A Kager; Bernard R Landau; Hans P Sauerwein
Glucose production and gluconeogenesis in adults with uncomplicated falciparum malaria.
The American journal of physiology 1997;272(6 Pt 1):E1059-64.
1996: Bernard R Landau; J Wahren; Stephen Previs; Karin Ekberg; Visvanathan Chandramouli; Henri Brunengraber
Glycerol production and utilization in humans: sites and quantitation.
The American journal of physiology 1996;271(6 Pt 1):E1110-7.
1996: Bernard R Landau; J Wahren; Visvanathan Chandramouli; William C Schumann; Karin Ekberg; Satish C Kalhan
Contributions of gluconeogenesis to glucose production in the fasted state.
The Journal of clinical investigation 1996;98(2):378-85.
1995: Karin Ekberg; Visvanathan Chandramouli; K Kumaran; William C Schumann; J Wahren; Bernard R Landau
Gluconeogenesis and glucuronidation in liver in vivo and the heterogeneity of hepatocyte function.
The Journal of biological chemistry 1995;270(37):21715-7.
1995: Bernard R Landau; C A Fernandez; Stephen Previs; Karin Ekberg; Visvanathan Chandramouli; J Wahren; Satish C Kalhan; Henri Brunengraber
A limitation in the use of mass isotopomer distributions to measure gluconeogenesis in fasting humans.
The American journal of physiology 1995;269(1 Pt 1):E18-26.
1995: Bernard R Landau; Visvanathan Chandramouli; William C Schumann; Karin Ekberg; K Kumaran; Satish C Kalhan; J Wahren
Estimates of Krebs cycle activity and contributions of gluconeogenesis to hepatic glucose production in fasting healthy subjects and IDDM patients.
Diabetologia 1995;38(7):831-8.
1995: Bernard R Landau; J Wahren; Visvanathan Chandramouli; William C Schumann; Karin Ekberg; Satish C Kalhan
Use of 2H2O for estimating rates of gluconeogenesis. Application to the fasted state.
The Journal of clinical investigation 1995;95(1):172-8.
1993: Visvanathan Chandramouli; K Kumaran; Karin Ekberg; J Wahren; Bernard R Landau
Quantitation of the pathways followed in the conversion of fructose to glucose in liver.
Metabolism: clinical and experimental 1993;42(11):1420-3.
1993: Bernard R Landau; William C Schumann; Visvanathan Chandramouli; I Magnusson; K Kumaran; J Wahren
14C-labeled propionate metabolism in vivo and estimates of hepatic gluconeogenesis relative to Krebs cycle flux.
The American journal of physiology 1993;265(4 Pt 1):E636-47.
1992: E Esenmo; Visvanathan Chandramouli; William C Schumann; K Kumaran; J Wahren; Bernard R Landau
Use of 14CO2 in estimating rates of hepatic gluconeogenesis.
The American journal of physiology 1992;263(1 Pt 1):E36-41.
1991: Visvanathan Chandramouli; Aisha Khan; C G Ostenson; Per-Olof Berggren; H Löw; Bernard R Landau; S E Efendić
Quantification of glucose cycling and the extent of equilibration of glucose 6-phosphate with fructose 6-phosphate in islets from ob/ob mice.
The Biochemical journal 1991;278 ( Pt 2)():353-9.
1991: A Wajngot; Visvanathan Chandramouli; William C Schumann; Suad Efendic; Bernard R Landau
Quantitation of glycogen/glucose-1-P cycling in liver.
Metabolism: clinical and experimental 1991;40(8):877-81.
1991: William C Schumann; I Magnusson; Visvanathan Chandramouli; K Kumaran; J Wahren; Bernard R Landau
Metabolism of [2-14C]acetate and its use in assessing hepatic Krebs cycle activity and gluconeogenesis.
The Journal of biological chemistry 1991;266(11):6985-90.
1991: I Magnusson; William C Schumann; G E Bartsch; Visvanathan Chandramouli; K Kumaran; J Wahren; Bernard R Landau
Noninvasive tracing of Krebs cycle metabolism in liver.
The Journal of biological chemistry 1991;266(11):6975-84.
1990: Gerald I Shulman; Gary W Cline; William C Schumann; Visvanathan Chandramouli; K Kumaran; Bernard R Landau
Quantitative comparison of pathways of hepatic glycogen repletion in fed and fasted humans.
The American journal of physiology 1990;259(3 Pt 1):E335-41.
1990: Aisha Khan; Visvanathan Chandramouli; C G Ostenson; Per-Olof Berggren; H Löw; Bernard R Landau; Suad Efendic
Glucose cycling is markedly enhanced in pancreatic islets of obese hyperglycemic mice.
Endocrinology 1990;126(5):2413-6.
1990: Aisha Khan; Visvanathan Chandramouli; C G Ostenson; H Löw; Bernard R Landau; S Efendić
Glucose cycling in islets from healthy and diabetic rats.
Diabetes 1990;39(4):456-9.
1990: I Magnusson; A Wennlund; Visvanathan Chandramouli; William C Schumann; K Kumaran; J Wahren; Bernard R Landau
Fructose-6-phosphate cycling and the pentose cycle in hyperthyroidism.
The Journal of clinical endocrinology and metabolism 1990;70(2):461-6.
1989: Aisha Khan; Visvanathan Chandramouli; C G Ostenson; B Ahrén; William C Schumann; H Löw; Bernard R Landau; S Efendić
Evidence for the presence of glucose cycling in pancreatic islets of the ob/ob mouse.
The Journal of biological chemistry 1989;264(17):9732-3.
1989: I Magnusson; Visvanathan Chandramouli; William C Schumann; K Kumaran; J Wahren; Bernard R Landau
Pathways of hepatic glycogen formation in humans following ingestion of a glucose load in the fed state.
Metabolism: clinical and experimental 1989;38(6):583-5.
1989: A Wajngot; Visvanathan Chandramouli; William C Schumann; K Kumaran; S Efendić; Bernard R Landau
Testing of the assumptions made in estimating the extent of futile cycling.
The American journal of physiology 1989;256(5 Pt 1):E668-75.
1988: I Magnusson; Visvanathan Chandramouli; William C Schumann; K Kumaran; J Wahren; Bernard R Landau
Pentose pathway in human liver.
Proceedings of the National Academy of Sciences of the United States of America 1988;85(13):4682-5.
1987: I Magnusson; Visvanathan Chandramouli; William C Schumann; K Kumaran; J Wahren; Bernard R Landau
Quantitation of the pathways of hepatic glycogen formation on ingesting a glucose load.
The Journal of clinical investigation 1987;80(6):1748-54.
1986: K Kosugi; Visvanathan Chandramouli; K Kumaran; William C Schumann; Bernard R Landau
Determinants in the pathways followed by the carbons of acetone in their conversion to glucose.
The Journal of biological chemistry 1986;261(28):13179-81.
1986: K Kosugi; R F Scofield; Visvanathan Chandramouli; K Kumaran; William C Schumann; Bernard R Landau
Pathways of acetone's metabolism in the rat.
The Journal of biological chemistry 1986;261(9):3952-7.
1985: R F Scofield; K Kosugi; Visvanathan Chandramouli; K Kumaran; William C Schumann; Bernard R Landau
The nature of the pentose pathway in liver.
The Journal of biological chemistry 1985;260(29):15439-44.