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Siddharthan Chandran

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Kunal Gupta; Giles E Hardingham; Siddharthan Chandran
NMDA receptor-dependent glutamate excitotoxicity in human embryonic stem cell-derived neurons.
Peter L Foley; Barry J Laird; Malcolm R Macleod; Emily Sena; Hanna M Vesterinen; Siddharthan Chandran; LA Colvin; Marie T Fallon
Prevalence and natural history of pain in adults with multiple sclerosis: systematic review and meta-analysis.
Kunal Gupta; Siddharthan Chandran; Giles E Hardingham
Human stem cell-derived astrocytes and their application to studying Nrf2-mediated neuroprotective pathways and therapeutics in neurodegeneration.

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All Publications

2013: Kunal Gupta; Giles E Hardingham; Siddharthan Chandran
NMDA receptor-dependent glutamate excitotoxicity in human embryonic stem cell-derived neurons.
Neuroscience letters 2013;543():95-100.
2013: Peter L Foley; Barry J Laird; Malcolm R Macleod; Emily Sena; Hanna M Vesterinen; Siddharthan Chandran; LA Colvin; Marie T Fallon
Prevalence and natural history of pain in adults with multiple sclerosis: systematic review and meta-analysis.
Pain 2013;154(5):632-42.
2013: Kunal Gupta; Siddharthan Chandran; Giles E Hardingham
Human stem cell-derived astrocytes and their application to studying Nrf2-mediated neuroprotective pathways and therapeutics in neurodegeneration.
British journal of clinical pharmacology 2013;75(4):907-18.
2013: Andrea Serio; Christopher E Shaw; Carole Shum; Rick Siller; David Story; Ian Wilmut; Chen Zhao; Dale Michael Ando; Sami J Barmada; Bilada Bilican; Karen Burr; Monica A Carrasco; Steven Finkbeiner; Ghazal Haghi; Tom Maniatis; Agnes Lumi Nishimura; Hemali P Phatnani; Siddharthan Chandran
Astrocyte pathology and the absence of non-cell autonomy in an induced pluripotent stem cell model of TDP-43 proteinopathy.
Proceedings of the National Academy of Sciences of the United States of America 2013;110(12):4697-702.
2012: Tomohiro Yamazaki; Biao Yan; Yong Yu; Bo Zhai; Aarti Sharma; Christopher E Shaw; Neil A Shneider; Gareth Sullivan; Juan C Tapia; Monica A Carrasco; Siddharthan Chandran; Shi Chen; Rita Das; Steve P Gygi; Tyler C Haertlein; Melanie Lalancette-Hebert; Tom Maniatis; Agnes Lumi Nishimura; Robin Reed
FUS-SMN protein interactions link the motor neuron diseases ALS and SMA.
Cell reports 2012;2(4):799-806.
2012: Rickie Patani; Clare A Puddifoot; Siddharthan Chandran; Giles E Hardingham; John Hardy; Patrick A Lewis; Colin Smith; Daniah Trabzuni; Robert Walker; Michael Weale; David J A Wyllie; Mina Ryten
Investigating the utility of human embryonic stem cell-derived neurons to model ageing and neurodegenerative disease using whole-genome gene expression and splicing analysis.
Journal of neurochemistry 2012;122(4):738-51.
2012: Thomas H Bak; Siddharthan Chandran
What wires together dies together: verbs, actions and neurodegeneration in motor neuron disease.
Cortex; a journal devoted to the study of the nervous system and behavior 2012;48(7):936-44.
2012: Rickie Patani; Christopher R Sibley; Siddharthan Chandran; Jernej Ule
Using human pluripotent stem cells to study post-transcriptional mechanisms of neurodegenerative diseases.
Brain research 2012;1462():129-38.
2012: David W Hampton; Neill Innes; Doron Merkler; Chao Zhao; Robin J M Franklin; Siddharthan Chandran
Focal immune-mediated white matter demyelination reveals an age-associated increase in axonal vulnerability and decreased remyelination efficiency.
The American journal of pathology 2012;180(5):1897-905.
2012: K Gupta; Giles E Hardingham; John D Hayes; R Patani; R A Pedersen; A Serio; D Story; T Tsujita; P Baxter; Siddharthan Chandran
Human embryonic stem cell derived astrocytes mediate non-cell-autonomous neuroprotection through endogenous and drug-induced mechanisms.
Cell death and differentiation 2012;19(5):779-87.
2012: Bilada Bilican; Monica Carrasco; Sami J Barmada; George Q Daley; Steven Finkbeiner; Judy Fletcher; Brad A Friedman; Giles E Hardingham; Tom Maniatis; Agnes Lumi Nishimura; In-Hyun Park; Hemali P Phatnani; Clare A Puddifoot; Andrea Serio; Christopher E Shaw; David Story; Gareth J Sullivan; Ian Wilmut; David J A Wyllie; Siddharthan Chandran
Mutant induced pluripotent stem cell lines recapitulate aspects of TDP-43 proteinopathies and reveal cell-specific vulnerability.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(15):5803-8.
2012: Peter Connick; Madhan Kolappan; Thomas H Bak; Siddharthan Chandran
Verbal fluency as a rapid screening test for cognitive impairment in progressive multiple sclerosis.
Journal of neurology, neurosurgery, and psychiatry 2012;83(3):346-7.
2012: Peter Connick; Charles Crawley; Ming-Qing Du; Madhan Kolappan; Shi-Lu Luan; Andrew W Michell; David H Miller; Rickie Patani; Michael A Scott; Alan J Thompson; Daniel J Webber; Daniel R Altmann; Alastair Compston; Siddharthan Chandran
Autologous mesenchymal stem cells for the treatment of secondary progressive multiple sclerosis: an open-label phase 2a proof-of-concept study.
Lancet neurology 2012;11(2):150-6.
2012: Sophie R Thomson; Thomas M Wishart; Siddharthan Chandran; Rickie Patani; Thomas H Gillingwater
Using induced pluripotent stem cells (iPSC) to model human neuromuscular connectivity: promise or reality?
Journal of anatomy 2012;220(2):122-30.
2012: Rickie Patani; Siddharthan Chandran
Experimental and therapeutic opportunities for stem cells in multiple sclerosis.
International journal of molecular sciences 2012;13(11):14470-91.
2012: Marija Sajic; Judith V Schweimer; Siddharthan Chandran; D Alastair S Compston; Norman A Gregson; David P J Hunt; Woojin Lee; Kenneth J Smith
Mesenchymal stem cells lack efficacy in the treatment of experimental autoimmune neuritis despite in vitro inhibition of T-cell proliferation.
PloS one 2012;7(2):e30708.
2011: Alexey Ruzov; Andrea Serio; Gareth J Sullivan; Yanina Tsenkina; Ian Wilmut; Yu Bai; Mark Bradley; Siddharthan Chandran; Tatiana Chebotareva; Tatiana Dudnakova; Judy Fletcher; Zara Hannoun; David C Hay; Steve Pells; Paul De Sousa
Lineage-specific distribution of high levels of genomic 5-hydroxymethylcytosine in mammalian development.
Cell research 2011;21(9):1332-42.
2011: S R L Stacpoole; Daniel J Webber; Bilada Bilican; Alastair Compston; R J M Franklin; X L He; R Karadottir; A Luzhynskaya; Siddharthan Chandran
Efficient derivation of NPCs, spinal motor neurons and midbrain dopaminergic neurons from hESCs at 3% oxygen.
Nature protocols 2011;6(8):1229-40.
2011: S R L Stacpoole; Bilada Bilican; Daniel J Webber; A Luzhynskaya; X L He; Alastair Compston; R Karadottir; R J M Franklin; Siddharthan Chandran
Derivation of neural precursor cells from human ES cells at 3% O(2) is efficient, enhances survival and presents no barrier to regional specification and functional differentiation.
Cell death and differentiation 2011;18(6):1016-23.
2011: Chin Lik Tan; Siddharthan Chandran; Charles ffrench-Constant; Jessica C F Kwok; Rickie Patani; James W Fawcett
Integrin activation promotes axon growth on inhibitory chondroitin sulfate proteoglycans by enhancing integrin signaling.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2011;31(17):6289-95.
2011: James R Tollervey; Tomaž Curk; Boris Rogelj; Michael Briese; Matteo Cereda; Melis Kayikci; Julian König; Tibor Hortobágyi; Agnes L Nishimura; Vera Zupunski; Rickie Patani; Siddharthan Chandran; Gregor Rot; Blaž Zupan; Christopher E Shaw; Jernej Ule
Characterizing the RNA targets and position-dependent splicing regulation by TDP-43.
Nature neuroscience 2011;14(4):452-8.
2011: Karen F Bell; Bashayer Al-Mubarak; Jill H Fowler; Paul S Baxter; Kunal Gupta; Tadayuki Tsujita; Sudhir Chowdhry; Rickie Patani; Siddharthan Chandran; Karen Horsburgh; John D Hayes; Giles E Hardingham
Mild oxidative stress activates Nrf2 in astrocytes, which contributes to neuroprotective ischemic preconditioning.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(1):E1-2; author reply E3-4.
2011: Peter Connick; Madhan Kolappan; Rickie Patani; Michael A Scott; Charles Crawley; Xiao-Ling He; Karen Richardson; Kelly Barber; Daniel J Webber; Claudia A M Wheeler-Kingshott; Daniel J Tozer; Rebecca S Samson; David L Thomas; Ming-Qing Du; Shi L Luan; Andrew W Michell; Daniel R Altmann; Alan J Thompson; David H Miller; Alastair Compston; Siddharthan Chandran
The mesenchymal stem cells in multiple sclerosis (MSCIMS) trial protocol and baseline cohort characteristics: an open-label pre-test: post-test study with blinded outcome assessments.
Trials 2011;12():62.
2011: R Patani; A J Hollins; T M Wishart; C A Puddifoot; S Alvarez; A R de Lera; David J A Wyllie; D A S Compston; Roger A Pedersen; T H Gillingwater; Giles E Hardingham; Nicholas D Allen; Siddharthan Chandran
Retinoid-independent motor neurogenesis from human embryonic stem cells reveals a medial columnar ground state.
Nature communications 2011;2():214.
2010: Hanna M Vesterinen; Emily S Sena; Charles ffrench-Constant; Anna Williams; Siddharthan Chandran; Malcolm R Macleod
Improving the translational hit of experimental treatments in multiple sclerosis.
Multiple sclerosis (Houndmills, Basingstoke, England) 2010;16(9):1044-55.
2010: Giles E Hardingham; Rickie Patani; Paul Baxter; David J Wyllie; Siddharthan Chandran
Human embryonic stem cell-derived neurons as a tool for studying neuroprotection and neurodegeneration.
Molecular neurobiology 2010;42(1):97-102.
2010: David W Hampton; Daniel J Webber; Bilada Bilican; Michel Goedert; Maria Grazia Spillantini; Siddharthan Chandran
Cell-mediated neuroprotection in a mouse model of human tauopathy.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2010;30(30):9973-83.
2010: David P Hunt; Marija Sajic; Helen Phillips; Deborah Henderson; Alastair Compston; Kenneth Smith; Siddharthan Chandran
Origins of gliogenic stem cell populations within adult skin and bone marrow.
Stem cells and development 2010;19(7):1055-65.
2010: Jane Marian Anderson; Rickie Patani; Richard Reynolds; Richard Nicholas; Alastair Compston; Maria Grazia Spillantini; Siddharthan Chandran
Abnormal tau phosphorylation in primary progressive multiple sclerosis.
Acta neuropathologica 2010;119(5):591-600.
2010: Mariangela Iovino; Rickie Patani; Colin Watts; Siddharthan Chandran; Maria Grazia Spillantini
Human stem cell-derived neurons: a system to study human tau function and dysfunction.
PloS one 2010;5(11):e13947.
2009: Daniel J Webber; Marka van Blitterswijk; Siddharthan Chandran
Neuroprotective effect of oligodendrocyte precursor cell transplantation in a long-term model of periventricular leukomalacia.
The American journal of pathology 2009;175(6):2332-42.
2009: Ludovic Vallier; Thomas Touboul; Stephanie Brown; Candy Cho; Bilada Bilican; Morgan Alexander; Jessica Cedervall; Siddharthan Chandran; Lars Ahrlund-Richter; Anne Weber; Roger A Pedersen
Signaling pathways controlling pluripotency and early cell fate decisions of human induced pluripotent stem cells.
Stem cells (Dayton, Ohio) 2009;27(11):2655-66.
2009: Siddharthan Chandran; Gail K Naughton
Tissue, cell and pathway engineering.
Current opinion in biotechnology 2009;20(5):509-10.
2009: David P J Hunt; Colin Jahoda; Siddharthan Chandran
Multipotent skin-derived precursors: from biology to clinical translation.
Current opinion in biotechnology 2009;20(5):522-30.
2009: Jane Marian Anderson; Rickie Patani; Richard Reynolds; Richard Nicholas; Alastair Compston; Maria Grazia Spillantini; Siddharthan Chandran
Evidence for abnormal tau phosphorylation in early aggressive multiple sclerosis.
Acta neuropathologica 2009;117(5):583-9.
2009: Rickie Patani; Alastair Compston; Clare A Puddifoot; David J A Wyllie; Giles E Hardingham; Nicholas D Allen; Siddharthan Chandran
Activin/Nodal inhibition alone accelerates highly efficient neural conversion from human embryonic stem cells and imposes a caudal positional identity.
PloS one 2009;4(10):e7327.
2008: David W Hampton; Jane Anderson; Gareth Pryce; Karen-Amanda Irvine; Gavin Giovannoni; James W Fawcett; Alastair Compston; Robin J M Franklin; David Baker; Siddharthan Chandran
An experimental model of secondary progressive multiple sclerosis that shows regional variation in gliosis, remyelination, axonal and neuronal loss.
Journal of neuroimmunology 2008;201-202():200-11.
2008: J M Anderson; David W Hampton; R Patani; G Pryce; R Anthony Crowther; R Reynolds; Robin J M Franklin; Gavin Giovannoni; D A S Compston; D Baker; Maria Grazia Spillantini; Siddharthan Chandran
Abnormally phosphorylated tau is associated with neuronal and axonal loss in experimental autoimmune encephalomyelitis and multiple sclerosis.
Brain : a journal of neurology 2008;131(Pt 7):1736-48.
2008: Alexis Joannides; Siddharthan Chandran
Human embryonic stem cells: an experimental and therapeutic resource for neurological disease.
Journal of the neurological sciences 2008;265(1-2):84-8.
2008: Joseph R Smith; Sean Maguire; Lesley A Davis; Morgan Alexander; Fentang Yang; Siddharthan Chandran; Charles ffrench-Constant; Roger A Pedersen
Robust, persistent transgene expression in human embryonic stem cells is achieved with AAVS1-targeted integration.
Stem cells (Dayton, Ohio) 2008;26(2):496-504.
2008: Siddharthan Chandran; Maeve Caldwell; Nick Allen
Introduction: stem cells and brain repair.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences 2008;363(1489):5-7.
2008: Siddharthan Chandran; David Hunt; Alexis Joannides; Chao Zhao; Alastair Compston; Robin J M Franklin
Myelin repair: the role of stem and precursor cells in multiple sclerosis.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences 2008;363(1489):171-83.
2008: D P J Hunt; K A Irvine; Daniel J Webber; D A S Compston; William F Blakemore; Siddharthan Chandran
Effects of direct transplantation of multipotent mesenchymal stromal/stem cells into the demyelinated spinal cord.
Cell transplantation 2008;17(7):865-73.
2008: Siddharthan Chandran
What are the prospects of stem cell therapy for neurology?
BMJ (Clinical research ed.) 2008;337():a1934.
2008: Bilada Bilican; Christelle Fiore-Heriche; Alastair Compston; Nicholas D Allen; Siddharthan Chandran
Induction of Olig2 precursors by FGF involves BMP signalling blockade at the Smad level.
PloS one 2008;3(8):e2863.
2008: David P J Hunt; Paul N Morris; Jane Sterling; Jane A Anderson; Alexis Joannides; Colin Jahoda; Alastair Compston; Siddharthan Chandran
A highly enriched niche of precursor cells with neuronal and glial potential within the hair follicle dermal papilla of adult skin.
Stem cells (Dayton, Ohio) 2008;26(1):163-72.
2007: Daniel J Webber; Alastair Compston; Siddharthan Chandran
Minimally manipulated oligodendrocyte precursor cells retain exclusive commitment to the oligodendrocyte lineage following transplantation into intact and injured hippocampus.
The European journal of neuroscience 2007;26(7):1791-800.
2007: Alexis Joannides; Daniel J Webber; Olivier Raineteau; Claire Kelly; Karen-Amanda Irvine; Colin Watts; Anne E Rosser; Paul J Kemp; William F Blakemore; Alastair Compston; Maeve A Caldwell; Nicholas D Allen; Siddharthan Chandran
Environmental signals regulate lineage choice and temporal maturation of neural stem cells from human embryonic stem cells.
Brain : a journal of neurology 2007;130(Pt 5):1263-75.
2007: Alexis Joannides; Christelle Fiore-Hériché; Alysia A Battersby; Pandula Athauda-Arachchi; Isabelle A Bouhon; Lydia Williams; Kristine Westmore; Paul J Kemp; Alastair Compston; Nicholas D Allen; Siddharthan Chandran
A scaleable and defined system for generating neural stem cells from human embryonic stem cells.
Stem cells (Dayton, Ohio) 2007;25(3):731-7.
2006: Isabelle A Bouhon; Alexis Joannides; Hidemasa Kato; Siddharthan Chandran; Nicholas D Allen
Embryonic stem cell-derived neural progenitors display temporal restriction to neural patterning.
Stem cells (Dayton, Ohio) 2006;24(8):1908-13.
2006: Henry Majed; Siddharthan Chandran; Simone Niclou; Richard S Nicholas; Alastair Wilkins; Mark G Wing; Kate E Rhodes; Maria Grazia Spillantini; Alastair Compston
A novel role for Sema3A in neuroprotection from injury mediated by activated microglia.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2006;26(6):1730-8.
2006: Phil Gaughwin; Maeve A Caldwell; J M Anderson; C J Schwiening; J W Fawcett; D A S Compston; Siddharthan Chandran
Astrocytes promote neurogenesis from oligodendrocyte precursor cells.
The European journal of neuroscience 2006;23(4):945-56.
2006: Alexis Joannides; Christelle Fiore-Hériché; Kristine Westmore; Maeve Caldwell; Alastair Compston; Nicholas Allen; Siddharthan Chandran
Automated mechanical passaging: a novel and efficient method for human embryonic stem cell expansion.
Stem cells (Dayton, Ohio) 2006;24(2):230-5.
2005: Isabelle A Bouhon; Hidemasa Kato; Siddharthan Chandran; Nicholas D Allen
Neural differentiation of mouse embryonic stem cells in chemically defined medium.
Brain research bulletin 2005;68(1-2):62-75.
2005: Siddharthan Chandran; Alastair Compston
Neural stem cells as a potential source of oligodendrocytes for myelin repair.
Journal of the neurological sciences 2005;233(1-2):179-81.
2005: John S Phillips; Jacquelyn A King; Siddharthan Chandran; Peter R Prinsley; David Dick
Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) presenting with sudden sensorineural hearing loss.
The Journal of laryngology and otology 2005;119(2):148-51.
2004: Siddharthan Chandran; Alastair Compston; Eric Jauniaux; Jennifer M Gilson; William F Blakemore; Clive Svendsen
Differential generation of oligodendrocytes from human and rodent embryonic spinal cord neural precursors.
Glia 2004;47(4):314-24.
2004: Alexis Joannides; Phil Gaughwin; Christof Schwiening; Henry Majed; Jane Sterling; Alastair Compston; Siddharthan Chandran
Efficient generation of neural precursors from adult human skin: astrocytes promote neurogenesis from skin-derived stem cells.
Lancet 2004;364(9429):172-8.
2003: Alexis Joannides; Phil Gaughwin; Mike Scott; Suzanne Watt; Alastair Compston; Siddharthan Chandran
Postnatal astrocytes promote neural induction from adult human bone marrow-derived stem cells.
Journal of hematotherapy & stem cell research 2003;12(6):681-8.
2003: Siddharthan Chandran; Hidemasa Kato; Dianne Gerreli; Alastair Compston; Clive Svendsen; Nicholas D Allen
FGF-dependent generation of oligodendrocytes by a hedgehog-independent pathway.
Development (Cambridge, England) 2003;130(26):6599-609.
2003: M Zarei; Siddharthan Chandran; Alastair Compston; John R Hodges
Cognitive presentation of multiple sclerosis: evidence for a cortical variant.
Journal of neurology, neurosurgery, and psychiatry 2003;74(7):872-7.
2003: Alastair Wilkins; Henry Majed; Robert Layfield; Alastair Compston; Siddharthan Chandran
Oligodendrocytes promote neuronal survival and axonal length by distinct intracellular mechanisms: a novel role for oligodendrocyte-derived glial cell line-derived neurotrophic factor.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2003;23(12):4967-74.
2002: M Zarei; V Peter Collins; Siddharthan Chandran; D Valler; J N P Higgins; D A S Compston; J R W Yates
Tuberous sclerosis presenting in late adult life.
Journal of neurology, neurosurgery, and psychiatry 2002;73(4):436-8.
2002: Sabine Golde; Siddharthan Chandran; Guy C Brown; Alastair Compston
Different pathways for iNOS-mediated toxicity in vitro dependent on neuronal maturation and NMDA receptor expression.
Journal of neurochemistry 2002;82(2):269-82.
1998: Clive Svendsen; MG ter Borg; Richard J E Armstrong; Anne E Rosser; Siddharthan Chandran; Thor Ostenfeld; Maeve A Caldwell
A new method for the rapid and long term growth of human neural precursor cells.
Journal of neuroscience methods 1998;85(2):141-52.
1998: Siddharthan Chandran; Clive Svendsen; Alastair Compston; Neil Scolding
Regional potential for oligodendrocyte generation in the rodent embryonic spinal cord following exposure to EGF and FGF-2.
Glia 1998;24(4):382-9.