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Srinivasan Chandrasekhar

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Songqing Na; Yanfei Ma; Jingyong Zhao; Clint Schmidt; Qing Q Zeng; Srinivasan Chandrasekhar; William W Chin; Sunil Nagpal
A Nonsecosteroidal Vitamin D Receptor Modulator Ameliorates Experimental Autoimmune Encephalomyelitis without Causing Hypercalcemia.
C A Swearingen; M G Chambers; C Lin; J Marimuthu; Christopher J Rito; Q L Carter; J Dotzlaf; C Liu; Srinivasan Chandrasekhar; Kevin Duffin; P G Mitchell; T B Durham; M R Wiley; Kannan Thirunavukkarasu
A short-term pharmacodynamic model for monitoring aggrecanase activity: injection of monosodium iodoacetate (MIA) in rats and assessment of aggrecan neoepitope release in synovial fluid using novel ELISAs.
Kannan Thirunavukkarasu; Yong Pei; Terry L Moore; Tao Wei; He Wang; Srinivasan Chandrasekhar
Regulation of NFATc2 gene expression by the transcription factor Runx2.

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All Publications

2011: Songqing Na; Yanfei Ma; Jingyong Zhao; Clint Schmidt; Qing Q Zeng; Srinivasan Chandrasekhar; William W Chin; Sunil Nagpal
A Nonsecosteroidal Vitamin D Receptor Modulator Ameliorates Experimental Autoimmune Encephalomyelitis without Causing Hypercalcemia.
Autoimmune diseases 2011;2011():132958.
2010: C A Swearingen; M G Chambers; C Lin; J Marimuthu; Christopher J Rito; Q L Carter; J Dotzlaf; C Liu; Srinivasan Chandrasekhar; Kevin Duffin; P G Mitchell; T B Durham; M R Wiley; Kannan Thirunavukkarasu
A short-term pharmacodynamic model for monitoring aggrecanase activity: injection of monosodium iodoacetate (MIA) in rats and assessment of aggrecan neoepitope release in synovial fluid using novel ELISAs.
Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society 2010;18(9):1159-66.
2007: Kannan Thirunavukkarasu; Yong Pei; Terry L Moore; Tao Wei; He Wang; Srinivasan Chandrasekhar
Regulation of NFATc2 gene expression by the transcription factor Runx2.
Molecular biology reports 2007;34(1):1-10.
2006: Yong Pei; Anita Harvey; Xiao-Peng Yu; Srinivasan Chandrasekhar; Kannan Thirunavukkarasu
Differential regulation of cytokine-induced MMP-1 and MMP-13 expression by p38 kinase inhibitors in human chondrosarcoma cells: potential role of Runx2 in mediating p38 effects.
Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society 2006;14(8):749-58.
2006: Kannan Thirunavukkarasu; Yong Pei; Terry L Moore; He Wang; Xiao-Peng Yu; Andrew G Geiser; Srinivasan Chandrasekhar
Regulation of the human ADAMTS-4 promoter by transcription factors and cytokines.
Biochemical and biophysical research communications 2006;345(1):197-204.
2006: Yanfei Ma; Berket Khalifa; Ying K Yee; Jianfen Lu; Ai Memezawa; Rajesh S Savkur; Yoko Yamamoto; Subba R Chintalacharuvu; Kazuyoshi Yamaoka; Keith R Stayrook; Kelli S Bramlett; Qing Q Zeng; Srinivasan Chandrasekhar; Xiao-Peng Yu; Jared H Linebarger; Stephen J Iturria; Burris thomas; Shigeaki Kato; William W Chin; Sunil Nagpal
Identification and characterization of noncalcemic, tissue-selective, nonsecosteroidal vitamin D receptor modulators.
The Journal of clinical investigation 2006;116(4):892-904.
2004: Jude E Onyia; Rachelle J Sells Galvin; Yanfei L Ma; David L Halladay; Rebecca R Miles; Xuhao Yang; Tina Fuson; Ricky L Cain; Qing Qiang Zeng; Srinivasan Chandrasekhar; Renee Emkey; Yanping Xu; Kannan Thirunavukkarasu; Henry Bryant; T John Martin
Novel and selective small molecule stimulators of osteoprotegerin expression inhibit bone resorption.
The Journal of pharmacology and experimental therapeutics 2004;309(1):369-79.
2003: Edelgard Kaiser; Srinivasan Chandrasekhar
Distinct pathways of extracellular signal-regulated kinase activation by growth factors, fibronectin and parathyroid hormone 1-34.
Biochemical and biophysical research communications 2003;305(3):573-8.
2002: Xuhao Yang; David L Halladay; Jude E Onyia; T John Martin; Srinivasan Chandrasekhar
Protein Kinase C is a mediator of the synthesis and secretion of osteoprotegerin in osteoblast-like cells.
Biochemical and biophysical research communications 2002;290(1):42-6.
2001: Kannan Thirunavukkarasu; Rebecca R Miles; David L Halladay; Xuhao Yang; Rachelle J Sells Galvin; Srinivasan Chandrasekhar; T John Martin; Jude E Onyia
Stimulation of osteoprotegerin (OPG) gene expression by transforming growth factor-beta (TGF-beta). Mapping of the OPG promoter region that mediates TGF-beta effects.
The Journal of biological chemistry 2001;276(39):36241-50.
2001: Yanfei L Ma; Ricky L Cain; David L Halladay; Xuhao Yang; Qingqiang Zeng; Rebecca R Miles; Srinivasan Chandrasekhar; T John Martin; Jude E Onyia
Catabolic effects of continuous human PTH (1--38) in vivo is associated with sustained stimulation of RANKL and inhibition of osteoprotegerin and gene-associated bone formation.
Endocrinology 2001;142(9):4047-54.
2001: David L Halladay; Rebecca R Miles; Kannan Thirunavukkarasu; Srinivasan Chandrasekhar; T John Martin; Jude E Onyia
Identification of signal transduction pathways and promoter sequences that mediate parathyroid hormone 1-38 inhibition of osteoprotegerin gene expression.
Journal of cellular biochemistry 2001;84(1):1-11.
2001: E Kaiser; Masahiko Sato; Jude E Onyia; Srinivasan Chandrasekhar
Parathyroid hormone (1-34) regulates integrin expression in vivo in rat osteoblasts.
Journal of cellular biochemistry 2001;83(4):617-30.
2000: L Jin; Stephen L Briggs; Srinivasan Chandrasekhar; Nikolay Y Chirgadze; David Clawson; Richard Schevitz; D L Smiley; A H Tashjian; F Zhang
Crystal structure of human parathyroid hormone 1-34 at 0.9-A resolution.
The Journal of biological chemistry 2000;275(35):27238-44.
2000: Kannan Thirunavukkarasu; David L Halladay; Rebecca R Miles; Xuhao Yang; Rachelle J Sells Galvin; Srinivasan Chandrasekhar; T John Martin; Jude E Onyia
The osteoblast-specific transcription factor Cbfa1 contributes to the expression of osteoprotegerin, a potent inhibitor of osteoclast differentiation and function.
The Journal of biological chemistry 2000;275(33):25163-72.
2000: Jude E Onyia; Rebecca R Miles; X Yang; David L Halladay; J Hale; A Glasebrook; D McClure; G Seno; L Churgay; Srinivasan Chandrasekhar; T John Martin
In vivo demonstration that human parathyroid hormone 1-38 inhibits the expression of osteoprotegerin in bone with the kinetics of an immediate early gene.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2000;15(5):863-71.
2000: George Boguslawski; Laura V Hale; XP Yu; Rebecca R Miles; Jude E Onyia; RF Santerre; Srinivasan Chandrasekhar
Activation of osteocalcin transcription involves interaction of protein kinase A- and protein kinase C-dependent pathways.
The Journal of biological chemistry 2000;275(2):999-1006.
1999: AK Harvey; XP Yu; Charles A Frolik; Srinivasan Chandrasekhar
Parathyroid hormone-(1-34) enhances aggrecan synthesis via an insulin-like growth factor-I pathway.
The Journal of biological chemistry 1999;274(33):23249-55.
1999: Charles A Frolik; Ricky L Cain; Masahiko Sato; AK Harvey; Srinivasan Chandrasekhar; Elwood C Black; A H Tashjian; Janet Hock
Comparison of recombinant human PTH(1-34) (LY333334) with a C-terminally substituted analog of human PTH-related protein(1-34) (RS-66271): In vitro activity and in vivo pharmacological effects in rats.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 1999;14(2):163-72.
1998: P McClelland; Jude E Onyia; Rebecca R Miles; Y Tu; J Liang; AK Harvey; Srinivasan Chandrasekhar; Janet Hock; Joseph P Bidwell
Intermittent administration of parathyroid hormone (1-34) stimulates matrix metalloproteinase-9 (MMP-9) expression in rat long bone.
Journal of cellular biochemistry 1998;70(3):391-401.
1997: XP Yu; Srinivasan Chandrasekhar
Parathyroid hormone (PTH 1-34) regulation of rat osteocalcin gene transcription.
Endocrinology 1997;138(8):3085-92.
1997: Jude E Onyia; B Miller; JF Hulman; J Liang; Rachelle J Sells Galvin; Charles A Frolik; Srinivasan Chandrasekhar; AK Harvey; J Bidwell; J Herring; Janet Hock
Proliferating cells in the primary spongiosa express osteoblastic phenotype in vitro.
Bone 1997;20(2):93-100.
1996: Srinivasan Chandrasekhar; AK Harvey
Modulation of PDGF mediated osteoblast chemotaxis by leukemia inhibitory factor (LIF).
Journal of cellular physiology 1996;169(3):481-90.
1996: D P Smith; X Y Zhang; Charles A Frolik; A Harvey; Srinivasan Chandrasekhar; E C Black; H M Hsiung
Structure and functional expression of a complementary DNA for porcine parathyroid hormone/parathyroid hormone-related peptide receptor.
Biochimica et biophysica acta 1996;1307(3):339-47.
1996: Charles A Frolik; Henry Bryant; E C Black; David Magee; Srinivasan Chandrasekhar
Time-dependent changes in biochemical bone markers and serum cholesterol in ovariectomized rats: effects of raloxifene HCl, tamoxifen, estrogen, and alendronate.
Bone 1996;18(6):621-7.
1994: Srinivasan Chandrasekhar; J A Panetta; A M Bendele
Inhibition of IL-1 induced articular inflammation of rats by 4-aminothiazolidines, LY 221068 and LY 269415.
Agents and actions 1994;42(1-2):67-70.
1994: Srinivasan Chandrasekhar; AK Harvey; M G Johnson; Gerald Becker
Osteonectin/SPARC is a product of articular chondrocytes/cartilage and is regulated by cytokines and growth factors.
Biochimica et biophysica acta 1994;1221(1):7-14.
1993: AK Harvey; S T Stack; Srinivasan Chandrasekhar
Differential modulation of degradative and repair responses of interleukin-1-treated chondrocytes by platelet-derived growth factor.
The Biochemical journal 1993;292 ( Pt 1)():129-36.
1993: Srinivasan Chandrasekhar; AK Harvey; S T Stack
Degradative and repair responses of cartilage to cytokines and growth factors occur via distinct pathways.
Agents and actions. Supplements 1993;39():121-5.
1992: Srinivasan Chandrasekhar; AK Harvey; P S Hrubey
Intra-articular administration of interleukin-1 causes prolonged suppression of cartilage proteoglycan synthesis in rats.
Matrix (Stuttgart, Germany) 1992;12(1):1-10.
1992: Srinivasan Chandrasekhar; AK Harvey
Differential regulation of metalloprotease steady-state mRNA levels by IL-1 and FGF in rabbit articular chondrocytes.
FEBS letters 1992;296(2):195-200.
1991: P S Hrubey; AK Harvey; A M Bendele; Srinivasan Chandrasekhar
Effects of anti-arthritic drugs on IL-1 induced inflammation in rats.
Agents and actions 1991;34(1-2):56-9.
1991: AK Harvey; P S Hrubey; Srinivasan Chandrasekhar
Transforming growth factor-beta inhibition of interleukin-1 activity involves down-regulation of interleukin-1 receptors on chondrocytes.
Experimental cell research 1991;195(2):376-85.
1990: Srinivasan Chandrasekhar; AK Harvey; J D Higginbotham; WE Horton
Interleukin-1-induced suppression of type II collagen gene transcription involves DNA regulatory elements.
Experimental cell research 1990;191(1):105-14.
1990: Srinivasan Chandrasekhar; AK Harvey; P S Hrubey; A M Bendele
Arthritis induced by interleukin-1 is dependent on the site and frequency of intraarticular injection.
Clinical immunology and immunopathology 1990;55(3):382-400.
1990: A M Bendele; J F Hulman; AK Harvey; P S Hrubey; Srinivasan Chandrasekhar
Passive role of articular chondrocytes in quinolone-induced arthropathy in guinea pigs.
Toxicologic pathology 1990;18(2):304-12.
1989: WE Horton; J D Higginbotham; Srinivasan Chandrasekhar
Transforming growth factor-beta and fibroblast growth factor act synergistically to inhibit collagen II synthesis through a mechanism involving regulatory DNA sequences.
Journal of cellular physiology 1989;141(1):8-15.
1989: Srinivasan Chandrasekhar; AK Harvey
Induction of interleukin-1 receptors on chondrocytes by fibroblast growth factor: a possible mechanism for modulation of interleukin-1 activity.
Journal of cellular physiology 1989;138(2):236-46.
1988: Srinivasan Chandrasekhar; AK Harvey
Transforming growth factor-beta is a potent inhibitor of IL-1 induced protease activity and cartilage proteoglycan degradation.
Biochemical and biophysical research communications 1988;157(3):1352-9.
1987: Srinivasan Chandrasekhar; AK Harvey
Synthesis of type IX collagen: effect of beta-xylosides.
Biochemical and biophysical research communications 1987;146(3):1040-6.