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George Chandy

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Hai M Nguyen; Raymond S Norton; Galina Schmunk; Brian J Smith; Robert A Edwards; Charles A Galea; K George Chandy
Intracellular trafficking of the KV1.3 potassium channel is regulated by the prodomain of a matrix metalloprotease.
Hai M Nguyen; Nobuyuki Nukina; Brian J Smith; Alan L Goldin; Naoto Hoshi; Haruko Miyazaki; K George Chandy
Modulation of voltage-gated K+ channels by the sodium channel β1 subunit.
Eric J Tarcha; Indra Tjong; Sanjeev K Upadhyay; David Bailey; Amy Banks; Christine Beeton; Scott E Boley; K George Chandy; Victor Chi; Zachary Hansen; Xueyou Hu; Dustin Kentala; Brian Knapp; Luz M Londono; Ernesto J Muñoz-Elías; Hai Nguyen; Kayla Norton; Michael Pennington; Greg W Ruppert; James Sams; Richard Slauter; Shawn P Iadonato
Durable pharmacological responses from the peptide ShK-186, a specific Kv1.3 channel inhibitor that suppresses T cell mediators of autoimmune disease.

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2013: Hai M Nguyen; Raymond S Norton; Galina Schmunk; Brian J Smith; Robert A Edwards; Charles A Galea; K George Chandy
Intracellular trafficking of the KV1.3 potassium channel is regulated by the prodomain of a matrix metalloprotease.
The Journal of biological chemistry 2013;288(9):6451-64.
2012: Hai M Nguyen; Nobuyuki Nukina; Brian J Smith; Alan L Goldin; Naoto Hoshi; Haruko Miyazaki; K George Chandy
Modulation of voltage-gated K+ channels by the sodium channel β1 subunit.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(45):18577-82.
2012: Eric J Tarcha; Indra Tjong; Sanjeev K Upadhyay; David Bailey; Amy Banks; Christine Beeton; Scott E Boley; K George Chandy; Victor Chi; Zachary Hansen; Xueyou Hu; Dustin Kentala; Brian Knapp; Luz M Londono; Ernesto J Muñoz-Elías; Hai Nguyen; Kayla Norton; Michael Pennington; Greg W Ruppert; James Sams; Richard Slauter; Shawn P Iadonato
Durable pharmacological responses from the peptide ShK-186, a specific Kv1.3 channel inhibitor that suppresses T cell mediators of autoimmune disease.
The Journal of pharmacology and experimental therapeutics 2012;342(3):642-53.
2012: Luigi Leanza; Nicola Sassi; K George Chandy; Erich Gulbins; Brian Henry; Mario Zoratti; Ildikò Szabò
Inhibitors of mitochondrial Kv1.3 channels induce Bax/Bak-independent death of cancer cells.
EMBO molecular medicine 2012;4(7):577-93.
2012: Anne R Gocke; Inna V Grishkan; Lina Hu; Lori A Lebson; Hai M Nguyen; Katharine A Whartenby; K George Chandy; Peter A Calabresi
Kv1.3 deletion biases T cells toward an immunoregulatory phenotype and renders mice resistant to autoimmune encephalomyelitis.
Journal of immunology (Baltimore, Md. : 1950) 2012;188(12):5877-86.
2012: Victor Chi; Shawn Iadonato; Jonathan T Lakey; Luz M Londono; Raymond S Norton; Michael Pennington; Brian Sims-Fahey; Eric J Tarcha; Sanjeev K Upadhyay; Heike Wulff; Christine Beeton; K George Chandy
Development of a sea anemone toxin as an immunomodulator for therapy of autoimmune diseases.
Toxicon : official journal of the International Society on Toxinology 2012;59(4):529-46.
2011: Evelyne Beraud; K George Chandy
Therapeutic potential of peptide toxins that target ion channels.
Inflammation & allergy drug targets 2011;10(5):322-42.
2011: Adriana Garcia; Jonathan Lakey; Norah Milne; Mohammad Reza Mirbolooki; K George Chandy; Cristian Constantinescu; Min-Liang Pan; Evegueni Sevrioukov; Ping H Wang; Jogeshwar Mukherjee
18F-Fallypride PET of pancreatic islets: in vitro and in vivo rodent studies.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2011;52(7):1125-32.
2011: Haik Mkhikian; Ani Grigorian; Carey F Li; Hung-Lin Chen; Barbara Newton; Raymond W Zhou; Christine Beeton; Sevan Torossian; Gevork Grikor Tatarian; Sung-Uk Lee; Ken Lau; Erin Walker; Katherine A Siminovitch; K George Chandy; Zhaoxia Yu; James W Dennis; Michael Demetriou
Genetics and the environment converge to dysregulate N-glycosylation in multiple sclerosis.
Nature communications 2011;2():334.
2010: srikant rangaraju; Keith K Khoo; Zhi-Ping Feng; George Crossley; Daniel Nugent; Ilya Khaytin; Victor Chi; Cory Pham; Peter A Calabresi; Michael Pennington; Raymond S Norton; K George Chandy
Potassium channel modulation by a toxin domain in matrix metalloprotease 23.
The Journal of biological chemistry 2010;285(12):9124-36.
2009: Michael D Cahalan; K George Chandy
The functional network of ion channels in T lymphocytes.
Immunological reviews 2009;231(1):59-87.
2009: srikant rangaraju; Victor Chi; Michael Pennington; K George Chandy
Kv1.3 potassium channels as a therapeutic target in multiple sclerosis.
Expert opinion on therapeutic targets 2009;13(8):909-24.
2008: Melanie P Matheu; Christine Beeton; Adriana Garcia; Victor Chi; srikant rangaraju; Olga Safrina; Kevin Monaghan; Marc I Uemura; Dan Li; Sukumar Pal; Luis M de la Maza; Edwin Monuki; Alexander Flügel; Michael Pennington; Ian Parker; K George Chandy; Michael D Cahalan
Imaging of effector memory T cells during a delayed-type hypersensitivity reaction and suppression by Kv1.3 channel block.
Immunity 2008;29(4):602-14.
2008: Kazuyoshi Toyama; Heike Wulff; K George Chandy; Philippe Azam; Girija Raman; Takashi Saito; Yoshimasa Fujiwara; David L Mattson; Satarupa Das; James E Melvin; Phillip F Pratt; Ossama A Hatoum; David D Gutterman; David R Harder; Hiroto Miura
The intermediate-conductance calcium-activated potassium channel KCa3.1 contributes to atherogenesis in mice and humans.
The Journal of clinical investigation 2008;118(9):3025-37.
2008: Christine Beeton; Brian J Smith; Jennifer K Sabo; George Crossley; Daniel Nugent; Ilya Khaytin; Victor Chi; K George Chandy; Michael Pennington; Raymond S Norton
The D-diastereomer of ShK toxin selectively blocks voltage-gated K+ channels and inhibits T lymphocyte proliferation.
The Journal of biological chemistry 2008;283(2):988-97.
2008: Melanie P Matheu; Christine Beeton; Ian Parker; K George Chandy; Michael D Cahalan
Imaging effector memory T cells in the ear after induction of adoptive DTH.
Journal of visualized experiments : JoVE 2008;(18):.
2007: Christine Beeton; K George Chandy
Induction and monitoring of adoptive delayed-type hypersensitivity in rats.
Journal of visualized experiments : JoVE 2007;(8):.
2007: Christine Beeton; K George Chandy
Induction and monitoring of active delayed type hypersensitivity (DTH) in rats.
Journal of visualized experiments : JoVE 2007;(6):237.
2007: Christine Beeton; Adriana Garcia; K George Chandy
Drawing blood from rats through the saphenous vein and by cardiac puncture.
Journal of visualized experiments : JoVE 2007;(7):266.
2007: Christine Beeton; K George Chandy
Isolation of mononuclear cells from the central nervous system of rats with EAE.
Journal of visualized experiments : JoVE 2007;(10):527.
2007: Christine Beeton; K George Chandy
Preparing T cell growth factor from rat splenocytes.
Journal of visualized experiments : JoVE 2007;(10):402.
2007: Christine Beeton; Adriana Garcia; K George Chandy
Induction and clinical scoring of chronic-relapsing experimental autoimmune encephalomyelitis.
Journal of visualized experiments : JoVE 2007;(5):224.
2007: Aaron Kolski-Andreaco; Haijiang Cai; D Spencer Currle; K George Chandy; Robert H Chow
Mouse adrenal chromaffin cell isolation.
Journal of visualized experiments : JoVE 2007;(2):129.
2006: Christine Beeton; Heike Wulff; Nathan E Standifer; Philippe Azam; Katherine M Mullen; Michael Pennington; Aaron Kolski-Andreaco; Eric Wei; Alexandra Grino; Debra R Counts; Ping H Wang; Christine J LeeHealey; Brian S Andrews; Ananthakrishnan Sankaranarayanan; Daniel Homerick; Werner W Roeck; Jamshid Tehranzadeh; Kimber L Stanhope; Pavel Zimin; Peter J Havel; Stephen M Griffey; Hans-Günther Knaus; Gerald Nepom; George A Gutman; Peter A Calabresi; K George Chandy
Kv1.3 channels are a therapeutic target for T cell-mediated autoimmune diseases.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(46):17414-9.
2005: George A Gutman; K George Chandy; Stephan Grissmer; Michel Lazdunski; David McKinnon; Luis A Pardo; Gail A Robertson; Bernardo Rudy; Michael C Sanguinetti; Walter Stühmer; Xiaoliang Wang
International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels.
Pharmacological reviews 2005;57(4):473-508.
2005: Aguan D Wei; George A Gutman; Richard Aldrich; K George Chandy; Stephan Grissmer; Heike Wulff
International Union of Pharmacology. LII. Nomenclature and molecular relationships of calcium-activated potassium channels.
Pharmacological reviews 2005;57(4):463-72.
2005: Christine Beeton; K George Chandy
Potassium channels, memory T cells, and multiple sclerosis.
The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry 2005;11(6):550-62.
2005: Horea Rus; CARLOS PARDO-VILLAMIZAR; Lina Hu; Erika Darrah; Cornelia Cudrici; Teodora Niculescu; Florin Niculescu; Katherine M Mullen; Rameeza Allie; Liping Guo; Heike Wulff; Christine Beeton; Susan I V Judge; Douglas A Kerr; Hans-Günther Knaus; K George Chandy; Peter A Calabresi
The voltage-gated potassium channel Kv1.3 is highly expressed on inflammatory infiltrates in multiple sclerosis brain.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(31):11094-9.
2005: Christine Beeton; Michael Pennington; Heike Wulff; Satendra Singh; Daniel Nugent; George Crossley; Ilya Khaytin; Peter A Calabresi; Chao Chen; George A Gutman; K George Chandy
Targeting effector memory T cells with a selective peptide inhibitor of Kv1.3 channels for therapy of autoimmune diseases.
Molecular pharmacology 2005;67(4):1369-81.
2004: Heike Wulff; Hans-Günther Knaus; Michael Pennington; K George Chandy
K+ channel expression during B cell differentiation: implications for immunomodulation and autoimmunity.
Journal of immunology (Baltimore, Md. : 1950) 2004;173(2):776-86.
2004: Julia Vennekamp; Heike Wulff; Christine Beeton; Peter A Calabresi; Stephan Grissmer; Wolfram Hänsel; K George Chandy
Kv1.3-blocking 5-phenylalkoxypsoralens: a new class of immunomodulators.
Molecular pharmacology 2004;65(6):1364-74.
2004: Claudio Villalobos; Vikram Shakkottai; K George Chandy; Sharon Kay Michelhaugh; Rodrigo Andrade
SKCa channels mediate the medium but not the slow calcium-activated afterhyperpolarization in cortical neurons.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2004;24(14):3537-42.
2004: Aaron Kolski-Andreaco; Hiroaki Tomita; Vikram Shakkottai; George A Gutman; Michael D Cahalan; J Jay Gargus; K George Chandy
SK3-1C, a dominant-negative suppressor of SKCa and IKCa channels.
The Journal of biological chemistry 2004;279(8):6893-904.
2004: Vikram Shakkottai; Chin-hua Chou; Salvatore Oddo; Claudia A Sailer; Hans-Günther Knaus; George A Gutman; Michael E Barish; Frank M LaFerla; K George Chandy
Enhanced neuronal excitability in the absence of neurodegeneration induces cerebellar ataxia.
The Journal of clinical investigation 2004;113(4):582-90.
2003: Ralf Köhler; Heike Wulff; Ines Eichler; Marlene Kneifel; Daniel Neumann; Andreas Knorr; Ivica Grgic; Doris Kämpfe; Han Si; Judith Wibawa; Robert Real; Klaus Borner; Susanne Brakemeier; Hans-Dieter Orzechowski; Hans-Peter Reusch; Martin Paul; K George Chandy; Joachim Hoyer
Blockade of the intermediate-conductance calcium-activated potassium channel as a new therapeutic strategy for restenosis.
Circulation 2003;108(9):1119-25.
2003: Heike Wulff; Christine Beeton; K George Chandy
Potassium channels as therapeutic targets for autoimmune disorders.
Current opinion in drug discovery & development 2003;6(5):640-7.
2003: Heike Wulff; Peter A Calabresi; Rameeza Allie; Sung Yun; Michael Pennington; Christine Beeton; K George Chandy
The voltage-gated Kv1.3 K(+) channel in effector memory T cells as new target for MS.
The Journal of clinical investigation 2003;111(11):1703-13.
2003: Hiroaki Tomita; Vikram Shakkottai; George A Gutman; Guifeng Sun; William E Bunney; Michael D Cahalan; K George Chandy; J Jay Gargus
Novel truncated isoform of SK3 potassium channel is a potent dominant-negative regulator of SK currents: implications in schizophrenia.
Molecular psychiatry 2003;8(5):524-35, 460.
2003: Christine Beeton; Heike Wulff; Satendra Singh; Steve Botsko; George Crossley; George A Gutman; Michael D Cahalan; Michael Pennington; K George Chandy
A novel fluorescent toxin to detect and investigate Kv1.3 channel up-regulation in chronically activated T lymphocytes.
The Journal of biological chemistry 2003;278(11):9928-37.
2002: Mark D Lanigan; Katalin Kalman; Yann Lefievre; Michael Pennington; K George Chandy; Raymond S Norton
Mutating a critical lysine in ShK toxin alters its binding configuration in the pore-vestibule region of the voltage-gated potassium channel, Kv1.3.
Biochemistry 2002;41(40):11963-71.
2002: Tokiyoshi Ayabe; Heike Wulff; Dalila Darmoul; Michael D Cahalan; K George Chandy; Andre J Ouellette
Modulation of mouse Paneth cell alpha-defensin secretion by mIKCa1, a Ca2+-activated, intermediate conductance potassium channel.
The Journal of biological chemistry 2002;277(5):3793-800.
2002: Soraya Bardien-Kruger; Heike Wulff; Zainu Arieff; Paul Brink; K George Chandy; Valerie A Corfield
Characterisation of the human voltage-gated potassium channel gene, KCNA7, a candidate gene for inherited cardiac disorders, and its exclusion as cause of progressive familial heart block I (PFHBI).
European journal of human genetics : EJHG 2002;10(1):36-43.
2001: Christine Beeton; Heike Wulff; Jocelyne Barbaria; O Clot-Faybesse; Michael Pennington; Dominique Bernard; Michael D Cahalan; K George Chandy; Evelyne Béraud
Selective blockade of T lymphocyte K(+) channels ameliorates experimental autoimmune encephalomyelitis, a model for multiple sclerosis.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(24):13942-7.
2001: Vikram Shakkottai; Imed Regaya; Heike Wulff; Ziad Fajloun; Hiroaki Tomita; Mohamed Fathallah; Michael D Cahalan; J Jay Gargus; Jean-Marc Sabatier; K George Chandy
Design and characterization of a highly selective peptide inhibitor of the small conductance calcium-activated K+ channel, SkCa2.
The Journal of biological chemistry 2001;276(46):43145-51.
2001: Heike Wulff; George A Gutman; Michael D Cahalan; K George Chandy
Delineation of the clotrimazole/TRAM-34 binding site on the intermediate conductance calcium-activated potassium channel, IKCa1.
The Journal of biological chemistry 2001;276(34):32040-5.
2001: Mark J Miller; H Rauer; H Tomita; H Rauer; J Jay Gargus; George A Gutman; Michael D Cahalan; K George Chandy
Nuclear localization and dominant-negative suppression by a mutant SKCa3 N-terminal channel fragment identified in a patient with schizophrenia.
The Journal of biological chemistry 2001;276(30):27753-6.
2001: M D Cahalan; Heike Wulff; K George Chandy
Molecular properties and physiological roles of ion channels in the immune system.
Journal of clinical immunology 2001;21(4):235-52.
2001: CM Fanger; H Rauer; AL Neben; Mark J Miller; H Rauer; Heike Wulff; J C Rosa; C R Ganellin; K George Chandy; Michael D Cahalan
Calcium-activated potassium channels sustain calcium signaling in T lymphocytes. Selective blockers and manipulated channel expression levels.
The Journal of biological chemistry 2001;276(15):12249-56.
2000: S Ghanshani; Heike Wulff; Mark J Miller; H Rohm; AL Neben; George A Gutman; Michael D Cahalan; K George Chandy
Up-regulation of the IKCa1 potassium channel during T-cell activation. Molecular mechanism and functional consequences.
The Journal of biological chemistry 2000;275(47):37137-49.
2000: Heike Wulff; Mark J Miller; W Hansel; Stephan Grissmer; Michael D Cahalan; K George Chandy
Design of a potent and selective inhibitor of the intermediate-conductance Ca2+-activated K+ channel, IKCa1: a potential immunosuppressant.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(14):8151-6.
2000: H Rauer; Mark D Lanigan; Michael Pennington; J Aiyar; S Ghanshani; Michael D Cahalan; Raymond S Norton; K George Chandy
Structure-guided transformation of charybdotoxin yields an analog that selectively targets Ca(2+)-activated over voltage-gated K(+) channels.
The Journal of biological chemistry 2000;275(2):1201-8.
1999: Michael Pennington; Mark D Lanigan; Katalin Kalman; Vladimir M Mahnir; H Rauer; C T McVaugh; D Behm; D Donaldson; K George Chandy; William R Kem; Raymond S Norton
Role of disulfide bonds in the structure and potassium channel blocking activity of ShK toxin.
Biochemistry 1999;38(44):14549-58.
1999: Jan Tytgat; K George Chandy; M L Garcia; George A Gutman; Marie-France Martin-Eauclaire; Jurg van der Walt; Lourival D Possani
A unified nomenclature for short-chain peptides isolated from scorpion venoms: alpha-KTx molecular subfamilies.
Trends in pharmacological sciences 1999;20(11):444-7.
1999: Stylianos E Antonarakis; Jean-Louis Blouin; Virginia K Lasseter; Corinne Gehrig; Uppala Radhakrishna; Gerald Nestadt; DE Housman; Haig Kazazian ; Katalin Kalman; George A Gutman; Emmanuelle Fantino; K George Chandy; J Jay Gargus; Ann E Pulver
Lack of linkage or association between schizophrenia and the polymorphic trinucleotide repeat within the KCNN3 gene on chromosome 1q21.
American journal of medical genetics 1999;88(4):348-51.
1999: H Rauer; Michael Pennington; Michael D Cahalan; K George Chandy
Structural conservation of the pores of calcium-activated and voltage-gated potassium channels determined by a sea anemone toxin.
The Journal of biological chemistry 1999;274(31):21885-92.
1999: Vardit Dror; Eyal Shamir; S Ghanshani; R Kimhi; M Swartz; Yoram Barak; Ronit Weizman; Lydia Avivi; T Litmanovitch; Emmanuelle Fantino; Katalin Kalman; E G Jones; K George Chandy; J Jay Gargus; George A Gutman; Ruth Navon
hKCa3/KCNN3 potassium channel gene: association of longer CAG repeats with schizophrenia in Israeli Ashkenazi Jews, expression in human tissues and localization to chromosome 1q21.
Molecular psychiatry 1999;4(3):254-60.
1999: D C Hanson; A Nguyen; R J Mather; H Rauer; K Koch; L E Burgess; James P Rizzi; C B Donovan; M J Bruns; P C Canniff; A C Cunningham; K A Verdries; E Mena; J C Kath; George A Gutman; Michael D Cahalan; Stephan Grissmer; K George Chandy
UK-78,282, a novel piperidine compound that potently blocks the Kv1.3 voltage-gated potassium channel and inhibits human T cell activation.
British journal of pharmacology 1999;126(8):1707-16.
1999: CM Fanger; S Ghanshani; N J Logsdon; H Rauer; Katalin Kalman; J Zhou; K Beckingham; K George Chandy; Michael D Cahalan; J Aiyar
Calmodulin mediates calcium-dependent activation of the intermediate conductance KCa channel, IKCa1.
The Journal of biological chemistry 1999;274(9):5746-54.
1998: Katalin Kalman; Michael Pennington; Mark D Lanigan; A Nguyen; H Rauer; Vladimir M Mahnir; K Paschetto; William R Kem; Stephan Grissmer; George A Gutman; E P Christian; Michael D Cahalan; Raymond S Norton; K George Chandy
ShK-Dap22, a potent Kv1.3-specific immunosuppressive polypeptide.
The Journal of biological chemistry 1998;273(49):32697-707.
1998: T Li; X Hu; K George Chandy; Emmanuelle Fantino; Katalin Kalman; George A Gutman; J Jay Gargus; B Freeman; R M Murray; E Dawson; X Liu; A T Bruinvels; P C Sham; D A Collier
Transmission disequilibrium analysis of a triplet repeat within the hKCa3 gene using family trios with schizophrenia.
Biochemical and biophysical research communications 1998;251(2):662-5.
1998: H L Li; Haixin Sui; S Ghanshani; S Lee; Peter J Walian; C L Wu; K George Chandy; Bing K Jap
Two-dimensional crystallization and projection structure of KcsA potassium channel.
Journal of molecular biology 1998;282(2):211-6.
1998: D Negulescu; Louis E-C Leong; K George Chandy; Bert L Semler; George A Gutman
Translation initiation of a cardiac voltage-gated potassium channel by internal ribosome entry.
The Journal of biological chemistry 1998;273(32):20109-13.
1998: S Ghanshani; M Coleman; P Gustavsson; A C Wu; J Jay Gargus; George A Gutman; N Dahl; Harvey W Mohrenweiser; K George Chandy
Human calcium-activated potassium channel gene KCNN4 maps to chromosome 19q13.2 in the region deleted in diamond-blackfan anemia.
Genomics 1998;51(1):160-1.
1998: Timothy Bowen; Carol A Guy; Nick Craddock; Alastair G Cardno; Nigel M Williams; Gillian Spurlock; Kieran C Murphy; Lisa Anne Jones; Marion Gray; Robert D Sanders; G McCarthy; K George Chandy; Emmanuelle Fantino; Katalin Kalman; George A Gutman; J Jay Gargus; Julie Williams; Peter McGuffin; Michael J Owen; Michael C O'Donovan
Further support for an association between a polymorphic CAG repeat in the hKCa3 gene and schizophrenia.
Molecular psychiatry 1998;3(3):266-9.
1998: Katalin Kalman; A Nguyen; Julie Tseng-Crank; I D Dukes; G Chandy; C M Hustad; N G Copeland; N A Jenkins; Harvey W Mohrenweiser; B Brandriff; Michael D Cahalan; George A Gutman; K George Chandy
Genomic organization, chromosomal localization, tissue distribution, and biophysical characterization of a novel mammalian Shaker-related voltage-gated potassium channel, Kv1.7.
The Journal of biological chemistry 1998;273(10):5851-7.
1998: Heike Jäger; H Rauer; A N Nguyen; J Aiyar; K George Chandy; Stephan Grissmer
Regulation of mammalian Shaker-related K+ channels: evidence for non-conducting closed and non-conducting inactivated states.
The Journal of physiology 1998;506 ( Pt 2)():291-301.
1998: K George Chandy; Emmanuelle Fantino; Oliver H Wittekindt; Katalin Kalman; L L Tong; T H Ho; George A Gutman; Marc-Antoine Crocq; Rohan Ganguli; Vishwajit L Nimgaonkar; Deborah J Morris-Rosendahl; J Jay Gargus
Isolation of a novel potassium channel gene hSKCa3 containing a polymorphic CAG repeat: a candidate for schizophrenia and bipolar disorder?
Molecular psychiatry 1998;3(1):32-7.
1997: M D Cahalan; K George Chandy
Ion channels in the immune system as targets for immunosuppression.
Current opinion in biotechnology 1997;8(6):749-56.
1997: R H Spencer; Yuri Sokolov; Huiying Li; B Takenaka; A J Milici; J Aiyar; A Nguyen; H Park; Bing K Jap; James E Hall; George A Gutman; K George Chandy
Purification, visualization, and biophysical characterization of Kv1.3 tetramers.
The Journal of biological chemistry 1997;272(4):2389-95.
1996: J Aiyar; J P Rizzi; George A Gutman; K George Chandy
The signature sequence of voltage-gated potassium channels projects into the external vestibule.
The Journal of biological chemistry 1996;271(49):31013-6.
1996: A Nguyen; J C Kath; D C Hanson; M S Biggers; P C Canniff; C B Donovan; R J Mather; M J Bruns; H Rauer; J Aiyar; A Lepple-Wienhues; George A Gutman; Stephan Grissmer; Michael D Cahalan; K George Chandy
Novel nonpeptide agents potently block the C-type inactivated conformation of Kv1.3 and suppress T cell activation.
Molecular pharmacology 1996;50(6):1672-9.
1996: R S Wymore; D Negulescu; K Kinoshita; Katalin Kalman; J Aiyar; George A Gutman; K George Chandy
Characterization of the transcription unit of mouse Kv1.4, a voltage-gated potassium channel gene.
The Journal of biological chemistry 1996;271(26):15629-34.
1994: J Aiyar; A N Nguyen; K George Chandy; Stephan Grissmer
The P-region and S6 of Kv3.1 contribute to the formation of the ion conduction pathway.
Biophysical journal 1994;67(6):2261-4.
1994: Stephan Grissmer; A N Nguyen; J Aiyar; D C Hanson; R J Mather; George A Gutman; M J Karmilowicz; D D Auperin; K George Chandy
Pharmacological characterization of five cloned voltage-gated K+ channels, types Kv1.1, 1.2, 1.3, 1.5, and 3.1, stably expressed in mammalian cell lines.
Molecular pharmacology 1994;45(6):1227-34.
1993: K George Chandy; G A Gutman
Nomenclature for mammalian potassium channel genes.
Trends in pharmacological sciences 1993;14(12):434.
1993: J Aiyar; Stephan Grissmer; K George Chandy
Full-length and truncated Kv1.3 K+ channels are modulated by 5-HT1c receptor activation and independently by PKC.
The American journal of physiology 1993;265(6 Pt 1):C1571-8.
1993: R H Spencer; K George Chandy; George A Gutman
Immunological identification of the Shaker-related Kv1.3 potassium channel protein in T and B lymphocytes, and detection of related proteins in files and yeast.
Biochemical and biophysical research communications 1993;191(1):201-6.
1993: M Strong; K George Chandy; George A Gutman
Molecular evolution of voltage-sensitive ion channel genes: on the origins of electrical excitability.
Molecular biology and evolution 1993;10(1):221-42.
1992: Stephan Grissmer; S Ghanshani; B Dethlefs; J D McPherson; JJ Wasmuth; George A Gutman; Michael D Cahalan; K George Chandy
The Shaw-related potassium channel gene, Kv3.1, on human chromosome 11, encodes the type l K+ channel in T cells.
The Journal of biological chemistry 1992;267(29):20971-9.
1992: R H Spencer; B K Brightman; D J Trepp; Hung Fan; K George Chandy
Induction of thymus-reestablishing lymphoid tumors by a murine leukemia virus carrying the avian v-myc oncogene.
Thymus 1992;20(1):47-61.
1992: S Ghanshani; M Pak; J D McPherson; M Strong; B Dethlefs; JJ Wasmuth; Lawrence Salkoff; George A Gutman; K George Chandy
Genomic organization, nucleotide sequence, and cellular distribution of a Shaw-related potassium channel gene, Kv3.3, and mapping of Kv3.3 and Kv3.4 to human chromosomes 19 and 1.
Genomics 1992;12(2):190-6.
1990: Stephan Grissmer; B Dethlefs; JJ Wasmuth; Alan L Goldin; George A Gutman; Michael D Cahalan; K George Chandy
Expression and chromosomal localization of a lymphocyte K+ channel gene.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(23):9411-5.
1990: Stephan Grissmer; D C Hanson; E J Natoli; Michael D Cahalan; K George Chandy
CD4-CD8- T cells from mice with collagen arthritis display aberrant expression of type l K+ channels.
Journal of immunology (Baltimore, Md. : 1950) 1990;145(7):2105-9.
1990: K George Chandy; Michael D Cahalan; Stephan Grissmer
Autoimmune diseases linked to abnormal K+ channel expression in double-negative CD4-CD8- T cells.
European journal of immunology 1990;20(4):747-51.
1990: K George Chandy; C B Williams; R H Spencer; B A Aguilar; S Ghanshani; Bruce Tempel; George A Gutman
A family of three mouse potassium channel genes with intronless coding regions.
Science (New York, N.Y.) 1990;247(4945):973-5.
1989: B K Brightman; K George Chandy; R H Spencer; Hung Fan
A T lymphoid cell line responds to a thymic stromal cell line by expression of Thy-1 and CD4.
Journal of immunology (Baltimore, Md. : 1950) 1989;143(9):2775-82.
1988: B K Brightman; K George Chandy; R H Spencer; Sudhir Gupta; P K Pattengale; Hung Fan
Characterization of lymphoid tumors induced by a recombinant murine retrovirus carrying the avian v-myc oncogene. Identification of novel (B-lymphoid) tumors in the thymus.
Journal of immunology (Baltimore, Md. : 1950) 1988;141(8):2844-54.
1988: Stephan Grissmer; Michael D Cahalan; K George Chandy
Abundant expression of type l K+ channels. A marker for lymphoproliferative diseases?
Journal of immunology (Baltimore, Md. : 1950) 1988;141(4):1137-42.
1987: B R Davis; B K Brightman; K George Chandy; Hung Fan
Characterization of a preleukemic state induced by Moloney murine leukemia virus: evidence for two infection events during leukemogenesis.
Proceedings of the National Academy of Sciences of the United States of America 1987;84(14):4875-9.
1986: B R Davis; K George Chandy; B K Brightman; Sudhir Gupta; Hung Fan
Effects of nonleukemogenic and wild-type Moloney murine leukemia virus on lymphoid cells in vivo: identification of a preleukemic shift in thymocyte subpopulations.
Journal of virology 1986;60(2):423-30.