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Bo Chang

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Bo Chang
Mouse models for studies of retinal degeneration and diseases.
Ji-Jing Pang; Wei Shi; Ye Tao; Yumiko Umino; Keqing Zhang; Sanford L Boye; Bo Chang; Vince A Chiodo; Xufeng Dai; Wen-Tao Deng; Drew Everhart; Bo Lei; Jie Li; Li Liu; Xuan Liu; Song Mao; William W Hauswirth
AAV-mediated cone rescue in a naturally occurring mouse model of CNGA3-achromatopsia.
Ji-Jing Pang; Xufeng Dai; Shannon E Boye; Ilaria Barone; Sanford L Boye; Song Mao; Drew Everhart; Astra Dinculescu; Li Liu; Yumiko Umino; Bo Lei; Bo Chang; Robert Barlow; Enrica Strettoi; William W Hauswirth
Long-term retinal function and structure rescue using capsid mutant AAV8 vector in the rd10 mouse, a model of recessive retinitis pigmentosa.

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All Publications

2013: Bo Chang
Mouse models for studies of retinal degeneration and diseases.
Methods in molecular biology (Clifton, N.J.) 2013;935():27-39.
2012: Ji-Jing Pang; Wei Shi; Ye Tao; Yumiko Umino; Keqing Zhang; Sanford L Boye; Bo Chang; Vince A Chiodo; Xufeng Dai; Wen-Tao Deng; Drew Everhart; Bo Lei; Jie Li; Li Liu; Xuan Liu; Song Mao; William W Hauswirth
AAV-mediated cone rescue in a naturally occurring mouse model of CNGA3-achromatopsia.
PloS one 2012;7(4):e35250.
2011: Ji-Jing Pang; Xufeng Dai; Shannon E Boye; Ilaria Barone; Sanford L Boye; Song Mao; Drew Everhart; Astra Dinculescu; Li Liu; Yumiko Umino; Bo Lei; Bo Chang; Robert Barlow; Enrica Strettoi; William W Hauswirth
Long-term retinal function and structure rescue using capsid mutant AAV8 vector in the rd10 mouse, a model of recessive retinitis pigmentosa.
Molecular therapy : the journal of the American Society of Gene Therapy 2011;19(2):234-42.
2011: Xia Li; Wensheng Li; Xufeng Dai; Fansheng Kong; Qinxiang Zheng; Xiangtian Zhou; Fan Lü; Bo Chang; Bärbel Rohrer; William W Hauswirth; Jia Qu; Ji-Jing Pang
Gene therapy rescues cone structure and function in the 3-month-old rd12 mouse: a model for midcourse RPE65 leber congenital amaurosis.
Investigative ophthalmology & visual science 2011;52(1):7-15.
2011: Jungyeon Won; Lan Ying Shi; Wanda Hicks; Jieping Wang; Ronald Hurd; Jürgen K Naggert; Bo Chang; Patsy M Nishina
Mouse model resources for vision research.
Journal of ophthalmology 2011;2011():391384.
2010: Jijing Pang; S E Boye; B Lei; Sanford L Boye; Drew Everhart; R Ryals; Yumiko Umino; B Rohrer; J Alexander; Jie Li; X Dai; Qin Li; Bo Chang; R Barlow; William W Hauswirth
Self-complementary AAV-mediated gene therapy restores cone function and prevents cone degeneration in two models of Rpe65 deficiency.
Gene therapy 2010;17(7):815-26.
2010: Ji-Jing Pang; John Alexander; Bo Lei; Wentao Deng; Keqing Zhang; Qiuhong Li; Bo Chang; William W Hauswirth
Achromatopsia as a potential candidate for gene therapy.
Advances in experimental medicine and biology 2010;664():639-46.
2010: Geoffrey D Lively; Bing Jiang; Adam Hedberg-Buenz; Bo Chang; Greg E Petersen; Kai Wang; Markus Kuehn; Michael G Anderson
Genetic dependence of central corneal thickness among inbred strains of mice.
Investigative ophthalmology & visual science 2010;51(1):160-71.
2009: Bo Chang; Tanja Grau; Susann Dangel; Ron Hurd; Bernhard Jurklies; E Cumhur Sener; sten andreasson; Hélène Dollfus; Britta Baumann; Sylvia Bolz; Nikolai Artemyev; Susanne Kohl; John R Heckenlively; Bernd Wissinger
A homologous genetic basis of the murine cpfl1 mutant and human achromatopsia linked to mutations in the PDE6C gene.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(46):19581-6.
2009: Wen-Tao Deng; Keisuke Sakurai; Jianwen Liu; Astra Dinculescu; Jie Li; Jijing Pang; Seok-Hong Min; Vince A Chiodo; Sanford L Boye; Bo Chang; Vladimir J Kefalov; William W Hauswirth
Functional interchangeability of rod and cone transducin alpha-subunits.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(42):17681-6.
2009: Mao Mao; Daniel R Thedens; Bo Chang; Belinda S Harris; Qing Yin Zheng; Kenneth R Johnson; Leah Rae Donahue; Michael G Anderson
The podosomal-adaptor protein SH3PXD2B is essential for normal postnatal development.
Mammalian genome : official journal of the International Mammalian Genome Society 2009;20(8):462-75.
2009: Wensheng Li; Fansheng Kong; Xia Li; Xufeng Dai; Xiaoqiang Liu; Qinxiang Zheng; Ronghan Wu; Xiangtian Zhou; Fan Lü; Bo Chang; Qiuhong Li; William W Hauswirth; Jia Qu; Ji-Jing Pang
Gene therapy following subretinal AAV5 vector delivery is not affected by a previous intravitreal AAV5 vector administration in the partner eye.
Molecular vision 2009;15():267-75.
2008: Michael G Anderson; Norman L Hawes; Colleen M Trantow; Bo Chang; Simon W M John
Iris phenotypes and pigment dispersion caused by genes influencing pigmentation.
Pigment cell & melanoma research 2008;21(5):565-78.
2008: Ji-Jing Pang; Sanford L Boye; Ashok Kumar; Astra Dinculescu; Wentao Deng; Jie Li; Qiuhong Li; Asha Rani; Thomas C Foster; Bo Chang; Norman L Hawes; Jeffrey H Boatright; William W Hauswirth
AAV-mediated gene therapy for retinal degeneration in the rd10 mouse containing a recessive PDEbeta mutation.
Investigative ophthalmology & visual science 2008;49(10):4278-83.
2008: Dennis M Maddox; Kirstan A Vessey; Gary L Yarbrough; Brandon M Invergo; Donald R Cantrell; Samsoon Inayat; Victoria Balannik; Wanda L Hicks; Norman L Hawes; Shannon Byers; Richard S Smith; Ronald E Hurd; Douglas Howell; Ronald G Gregg; Bo Chang; Jürgen K Naggert; John B Troy; Lawrence H Pinto; Patsy M Nishina; Maureen A McCall
Allelic variance between GRM6 mutants, Grm6nob3 and Grm6nob4 results in differences in retinal ganglion cell visual responses.
The Journal of physiology 2008;586(Pt 18):4409-24.
2007: John J Alexander; Yumiko Umino; Drew Everhart; Bo Chang; Seok-Hong Min; Qiuhong Li; Adrian M Timmers; Norman L Hawes; Ji-Jing Pang; Robert B Barlow; William W Hauswirth
Restoration of cone vision in a mouse model of achromatopsia.
Nature medicine 2007;13(6):685-7.
2007: Bo Chang; Norman L Hawes; Machelle T Pardue; A M German; Ronald E Hurd; Muriel T Davisson; Steven Nusinowitz; Kalpana Rengarajan; A P Boyd; Sheree S Sidney; M J Phillips; Rachael E Stewart; R Chaudhury; John M Nickerson; John R Heckenlively; Jeffrey H Boatright
Two mouse retinal degenerations caused by missense mutations in the beta-subunit of rod cGMP phosphodiesterase gene.
Vision research 2007;47(5):624-33.
2006: Bo Chang; Mark S Dacey; Norman L Hawes; Peter F Hitchcock; Ann H Milam; Pelin Atmaca Sonmez; Steven Nusinowitz; John R Heckenlively
Cone photoreceptor function loss-3, a novel mouse model of achromatopsia due to a mutation in Gnat2.
Investigative ophthalmology & visual science 2006;47(11):5017-21.
2006: Steven Nusinowitz; William H Ridder; Ji-Jing Pang; Bo Chang; Syed M Noorwez; Shalesh Kaushal; William W Hauswirth; John R Heckenlively
Cortical visual function in the rd12 mouse model of Leber Congenital Amarousis (LCA) after gene replacement therapy to restore retinal function.
Vision research 2006;46(22):3926-34.
2006: Bo Chang; Hemant Khanna; Norman L Hawes; David Jimeno; Shirley He; Concepcion Lillo; Sunil K Parapuram; Hong Cheng; Alison Scott; Ronald E Hurd; John A Sayer; Edgar Otto; Massimo Attanasio; John F O'Toole; Genglin Jin; Chengchao Shou; Friedhelm Hildebrandt; David S Williams; John R Heckenlively; Anand Swaroop
In-frame deletion in a novel centrosomal/ciliary protein CEP290/NPHP6 perturbs its interaction with RPGR and results in early-onset retinal degeneration in the rd16 mouse.
Human molecular genetics 2006;15(11):1847-57.
2006: Eiko Kitamura; Michael Danciger; Clyde K Yamashita; Nagesh P Rao; Steven Nusinowitz; Bo Chang; Debora B Farber
Disruption of the gene encoding the beta1-subunit of transducin in the Rd4/+ mouse.
Investigative ophthalmology & visual science 2006;47(4):1293-301.
2006: Bonnie L Lyons; Richard S Smith; Ronald E Hurd; Norman L Hawes; Lisa M Burzenski; Steven Nusinowitz; Muneer G Hasham; Bo Chang; Leonard D Shultz
Deficiency of SHP-1 protein-tyrosine phosphatase in "viable motheaten" mice results in retinal degeneration.
Investigative ophthalmology & visual science 2006;47(3):1201-9.
2006: Ji-Jing Pang; Bo Chang; Ashok Kumar; Steven Nusinowitz; Syed M Noorwez; Jie Li; Asha Rani; Thomas C Foster; Vince A Chiodo; Thomas Doyle; Huashi Li; Ritu Malhotra; Jacqueline T Teusner; J Hugh McDowell; Seok-Hong Min; Qiuhong Li; Shalesh Kaushal; William W Hauswirth
Gene therapy restores vision-dependent behavior as well as retinal structure and function in a mouse model of RPE65 Leber congenital amaurosis.
Molecular therapy : the journal of the American Society of Gene Therapy 2006;13(3):565-72.
2006: Jeffrey H Boatright; Anisha G Moring; Clinton McElroy; Michael J Phillips; Vi T Do; Bo Chang; Norman L Hawes; Amber P Boyd; Sheree S Sidney; Rachael E Stewart; Steven C Minear; Rajashree Chaudhury; Vincent T Ciavatta; Cecília M P Rodrigues; Clifford J Steer; John M Nickerson; Machelle T Pardue
Tool from ancient pharmacopoeia prevents vision loss.
Molecular vision 2006;12():1706-14.
2006: Bo Chang; John R Heckenlively; Philippa R Bayley; Nicholas Brecha; Muriel T Davisson; Norman L Hawes; Arlene A Hirano; Ronald E Hurd; Akihiro Ikeda; Britt A Johnson; Maureen A McCall; Catherine W Morgans; Steven Nusinowitz; Neal S Peachey; Dennis S Rice; Kirstan A Vessey; Ronald G Gregg
The nob2 mouse, a null mutation in Cacna1f: anatomical and functional abnormalities in the outer retina and their consequences on ganglion cell visual responses.
Visual neuroscience 2006;23(1):11-24.
2005: Bo Chang; Norman L Hawes; Ronald E Hurd; J Wang; D Howell; Muriel T Davisson; TH Roderick; Steven Nusinowitz; John R Heckenlively
Mouse models of ocular diseases.
Visual neuroscience 2005;22(5):587-93.
2005: Ji-Jing Pang; Bo Chang; Norman L Hawes; Ronald E Hurd; Muriel T Davisson; Jie Li; Syed M Noorwez; Ritu Malhotra; J Hugh McDowell; Shalesh Kaushal; William W Hauswirth; Steven Nusinowitz; Debra A Thompson; John R Heckenlively
Retinal degeneration 12 (rd12): a new, spontaneously arising mouse model for human Leber congenital amaurosis (LCA).
Molecular vision 2005;11():152-62.
2003: Kenneth R Johnson; Leona H Gagnon; Lisa S Webb; Luanne L Peters; Norman L Hawes; Bo Chang; Qing Yin Zheng
Mouse models of USH1C and DFNB18: phenotypic and molecular analyses of two new spontaneous mutations of the Ush1c gene.
Human molecular genetics 2003;12(23):3075-86.
2003: Leah Rae Donahue; Bo Chang; Subburaman Mohan; Naohisa Miyakoshi; Jon E Wergedal; David J Baylink; Norman L Hawes; Clifford J Rosen; Patricia Ward-Bailey; Qing Yin Zheng; Roderick T Bronson; Kenneth R Johnson; Muriel T Davisson
A missense mutation in the mouse Col2a1 gene causes spondyloepiphyseal dysplasia congenita, hearing loss, and retinoschisis.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2003;18(9):1612-21.
2003: Adrienne K Mehalow; Shuhei Kameya; Richard S Smith; Norman L Hawes; James M Denegre; James A Young; Lesley Bechtold; Neena B Haider; Ulrich Tepass; John R Heckenlively; Bo Chang; Jürgen K Naggert; Patsy M Nishina
CRB1 is essential for external limiting membrane integrity and photoreceptor morphogenesis in the mammalian retina.
Human molecular genetics 2003;12(17):2179-89.
2003: John R Heckenlively; Norman L Hawes; Martin Friedlander; Steven Nusinowitz; Ronald Hurd; Muriel T Davisson; Bo Chang
Mouse model of subretinal neovascularization with choroidal anastomosis.
Retina (Philadelphia, Pa.) 2003;23(4):518-22.
2002: Shuhei Kameya; Norman L Hawes; Bo Chang; John R Heckenlively; Jürgen K Naggert; Patsy M Nishina
Mfrp, a gene encoding a frizzled related protein, is mutated in the mouse retinal degeneration 6.
Human molecular genetics 2002;11(16):1879-86.
2002: Bo Chang; Xin Wang; Norman L Hawes; Ryan Ojakian; Muriel T Davisson; Woo-Kuen Lo; Xiaohua Gong
A Gja8 (Cx50) point mutation causes an alteration of alpha 3 connexin (Cx46) in semi-dominant cataracts of Lop10 mice.
Human molecular genetics 2002;11(5):507-13.
2002: Bo Chang; Norman L Hawes; Ronald E Hurd; Muriel T Davisson; Steven Nusinowitz; John R Heckenlively
Retinal degeneration mutants in the mouse.
Vision research 2002;42(4):517-25.
2002: Michael G Anderson; Richard S Smith; Norman L Hawes; Adriana Zabaleta; Bo Chang; Janey L Wiggs; Simon W M John
Mutations in genes encoding melanosomal proteins cause pigmentary glaucoma in DBA/2J mice.
Nature genetics 2002;30(1):81-5.
2001: Bo Chang; Richard S Smith; M Peters; Olga V Savinova; Norman L Hawes; Adriana Zabaleta; Steven Nusinowitz; Janice E Martin; M L Davisson; C L Cepko; Brigid L M Hogan; Simon W M John
Haploinsufficient Bmp4 ocular phenotypes include anterior segment dysgenesis with elevated intraocular pressure.
BMC genetics 2001;2():18.
2001: Michael G Anderson; Richard S Smith; Olga V Savinova; Norman L Hawes; Bo Chang; Adriana Zabaleta; R Wilpan; John R Heckenlively; Muriel T Davisson; Simon W M John
Genetic modification of glaucoma associated phenotypes between AKXD-28/Ty and DBA/2J mice.
BMC genetics 2001;2():1.
2000: Norman L Hawes; Bo Chang; G S Hageman; Steven Nusinowitz; Patsy M Nishina; B S Schneider; Richard S Smith; TH Roderick; Muriel T Davisson; John R Heckenlively
Retinal degeneration 6 (rd6): a new mouse model for human retinitis punctata albescens.
Investigative ophthalmology & visual science 2000;41(10):3149-57.
2000: Novrouz B Akhmedov; Natik I Piriev; Bo Chang; A L Rapoport; Norman L Hawes; Patsy M Nishina; Steven Nusinowitz; John R Heckenlively; TH Roderick; CA Kozak; Michael Danciger; Muriel T Davisson; Debora B Farber
A deletion in a photoreceptor-specific nuclear receptor mRNA causes retinal degeneration in the rd7 mouse.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(10):5551-6.
2000: Richard S Smith; Simon W M John; A Zabeleta; Muriel T Davisson; Norman L Hawes; Bo Chang
The bst locus on mouse chromosome 16 is associated with age-related subretinal neovascularization.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(5):2191-5.
2000: Richard S Smith; Norman L Hawes; Bo Chang; TH Roderick; Ellen C Akeson; John R Heckenlively; X Gong; X Wang; Muriel T Davisson
Lop12, a mutation in mouse Crygd causing lens opacity similar to human Coppock cataract.
Genomics 2000;63(3):314-20.
1999: Norman L Hawes; Richard S Smith; Bo Chang; Muriel T Davisson; John R Heckenlively; Simon W M John
Mouse fundus photography and angiography: a catalogue of normal and mutant phenotypes.
Molecular vision 1999;5():22.
1999: Bo Chang; Norman L Hawes; TH Roderick; Richard S Smith; John R Heckenlively; J Horwitz; Muriel T Davisson
Identification of a missense mutation in the alphaA-crystallin gene of the lop18 mouse.
Molecular vision 1999;5():21.
1999: S Ikeda; Norman L Hawes; Bo Chang; C S Avery; Richard S Smith; Patsy M Nishina
Severe ocular abnormalities in C57BL/6 but not in 129/Sv p53-deficient mice.
Investigative ophthalmology & visual science 1999;40(8):1874-8.
1999: Yingzi Xue; X Gao; C E Lindsell; Christine R Norton; Bo Chang; C Hicks; M Gendron-Maguire; Elizabeth B Rand; Gerry Weinmaster; Thomas Gridley
Embryonic lethality and vascular defects in mice lacking the Notch ligand Jagged1.
Human molecular genetics 1999;8(5):723-30.
1999: Bo Chang; Richard S Smith; Norman L Hawes; Michael G Anderson; Adriana Zabaleta; Olga V Savinova; TH Roderick; John R Heckenlively; Muriel T Davisson; Simon W M John
Interacting loci cause severe iris atrophy and glaucoma in DBA/2J mice.
Nature genetics 1999;21(4):405-9.
1998: Simon W M John; Richard S Smith; Olga V Savinova; Norman L Hawes; Bo Chang; Daniel Turnbull; Muriel T Davisson; TH Roderick; John R Heckenlively
Essential iris atrophy, pigment dispersion, and glaucoma in DBA/2J mice.
Investigative ophthalmology & visual science 1998;39(6):951-62.
1997: TH Roderick; Bo Chang; Norman L Hawes; John R Heckenlively
A new dominant retinal degeneration (Rd4) associated with a chromosomal inversion in the mouse.
Genomics 1997;42(3):393-6.
1996: Bo Chang; Norman L Hawes; Richard S Smith; John R Heckenlively; Muriel T Davisson; TH Roderick
Chromosomal localization of a new mouse lens opacity gene (lop18)
Genomics 1996;36(1):171-3.
1996: Richard S Smith; Norman L Hawes; S D Kuhlmann; John R Heckenlively; Bo Chang; TH Roderick; J P Sundberg
Corn1: a mouse model for corneal surface disease and neovascularization.
Investigative ophthalmology & visual science 1996;37(2):397-404.
1995: John R Heckenlively; Bo Chang; L C Erway; C Peng; Norman L Hawes; G S Hageman; TH Roderick
Mouse model for Usher syndrome: linkage mapping suggests homology to Usher type I reported at human chromosome 11p15.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(24):11100-4.
1994: Bo Chang; R T Bronson; Norman L Hawes; TH Roderick; C Peng; G S Hageman; John R Heckenlively
Retinal degeneration in motor neuron degeneration: a mouse model of ceroid lipofuscinosis.
Investigative ophthalmology & visual science 1994;35(3):1071-6.
1993: Bo Chang; John R Heckenlively; Norman L Hawes; TH Roderick
New mouse primary retinal degeneration (rd-3).
Genomics 1993;16(1):45-9.