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Hyeun Wook Chang

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Seung-Lark Hwang; Yong-Tae Jeong; Yong Deuk Kim; In-Kyu Lee; Xian Li; Yue Lu; Young-Chae Chang; Hyeun Wook Chang
Inhibitory cross-talk between the AMPK and ERK pathways mediates endoplasmic reticulum stress-induced insulin resistance in skeletal muscle.
Ying Li; Dong-Cheul Moon; Donggen Piao; Hyeun Wook Chang; Je-Hyun Lee; Seung-Ho Lee; Mi-Hee Woo; Haiyan Zhang; Jong Keun Son
Quality assessment and discrimination of the roots of Cynanchum auriculatum and Cynanchum wilfordii by HPLC-UV analysis.
Hyo-Hyun Park; Hyun-Je Park; Young Na Park; Jong Keun Son; Hyeun Wook Chang; Mi Jin Kim; Sun-Gun Kim; Jiean Lee; Youn Ju Lee; Ying Li; Eunkyung Lee
Britanin suppresses LPS-induced nitric oxide, PGE2 and cytokine production via NF-κB and MAPK inactivation in RAW 264.7 cells.

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2013: Seung-Lark Hwang; Yong-Tae Jeong; Yong Deuk Kim; In-Kyu Lee; Xian Li; Yue Lu; Young-Chae Chang; Hyeun Wook Chang
Inhibitory cross-talk between the AMPK and ERK pathways mediates endoplasmic reticulum stress-induced insulin resistance in skeletal muscle.
British journal of pharmacology 2013;169(1):69-81.
2013: Ying Li; Dong-Cheul Moon; Donggen Piao; Hyeun Wook Chang; Je-Hyun Lee; Seung-Ho Lee; Mi-Hee Woo; Haiyan Zhang; Jong Keun Son
Quality assessment and discrimination of the roots of Cynanchum auriculatum and Cynanchum wilfordii by HPLC-UV analysis.
Archives of pharmacal research 2013;36(3):335-44.
2013: Hyo-Hyun Park; Hyun-Je Park; Young Na Park; Jong Keun Son; Hyeun Wook Chang; Mi Jin Kim; Sun-Gun Kim; Jiean Lee; Youn Ju Lee; Ying Li; Eunkyung Lee
Britanin suppresses LPS-induced nitric oxide, PGE2 and cytokine production via NF-κB and MAPK inactivation in RAW 264.7 cells.
International immunopharmacology 2013;15(2):296-302.
2013: Tae-Wook Chung; Ki-Tae Ha; Hyeun Wook Chang; Young-Chae Chang; Hee-Jung Choi; Keuk Jun Kim; Seok-Jo Kim; Choong-Hwan Kwak; Young-Choon Lee; Young-Guk Park; Kwon-Ho Song; Seok-Jong Suh; Cheorl-Ho Kim
CAPE suppresses VEGFR-2 activation, and tumor neovascularization and growth.
Journal of molecular medicine (Berlin, Germany) 2013;91(2):271-82.
2013: Seung-Lark Hwang; Yong-Tae Jeong; Yong Deuk Kim; Xian Li; Yue Lu; Kun Ho Son; Ju Hye Yang; Young-Chae Chang; Hyeun Wook Chang
Tanshinone IIA improves endoplasmic reticulum stress-induced insulin resistance through AMP-activated protein kinase.
Biochemical and biophysical research communications 2013;430(4):1246-52.
2013: Seok-Jo Kim; Choong-Hwan Kwak; Kyung-Min Kwon; Hyeun Wook Chang; Young-Chae Chang; Hee-Jung Choi; Tae-Wook Chung; Cheorl-Ho Kim; Kyoung-Sook Kim; Young-Guk Park; Kwon-Ho Song; Seok-Jong Suh; Young-Choon Lee
Ganglioside GM3 participates in the TGF-β1-induced epithelial-mesenchymal transition of human lens epithelial cells.
The Biochemical journal 2013;449(1):241-51.
2012: Kyung Min Park; Dong Gen Piao; Mi-Hee Woo; Haiyan Zhang; Hyeun Wook Chang; Mei Juan Chi; Jae Sue Choi; Kyong Hwangbo; Bora Kim; Jae-Ryong Kim; Je-Hyun Lee; Ying Li; Dong-Cheul Moon; Jong Keun Son
High-performance liquid chromatographic analysis for quantitation of marker compounds of Artemisia capillaris Thunb.
Archives of pharmacal research 2012;35(12):2153-62.
2012: Yun-Jeong Jeong; Cheorl-Ho Kim; Wun-Jae Kim; In-Seon Lee; Sung-Kwon Moon; Kwan-Kyu Park; Key Whang; Hyun-Ji Cho; Jung-Yoon Choe; Yung Hyun Choi; Sang-Mi Han; Hyeun Wook Chang; Young-Chae Chang
Melittin has an inhibitory effect on TNF-α-induced migration of human aortic smooth muscle cells by blocking the MMP-9 expression.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2012;50(11):3996-4002.
2012: Yue Lu; Hyo-Hyun Park; Young Na Park; Jong Keun Son; Ju Hye Yang; Guang Hsuan Chao; Meihua Jin; Eunkyung Lee; Xian Li; Ying Li; Hyeun Wook Chang
Inula japonica extract inhibits mast cell-mediated allergic reaction and mast cell activation.
Journal of ethnopharmacology 2012;143(1):151-7.
2012: Seok-Jong Suh; Hyeun Wook Chang; Young-Chae Chang; Meijuan Cheeeei; Tae-Wook Chung; Choong-Hwan Kwak; Young-Choon Lee; Soon Jin Park; Sung-Soo Park; Young-Guk Park; Chang-Seob Seo; Jong-Keun Son; Cheorl-Ho Kim
Pimaric acid from Aralia cordata has an inhibitory effect on TNF-α-induced MMP-9 production and HASMC migration via down-regulated NF-κB and AP-1.
Chemico-biological interactions 2012;199(2):112-9.
2012: Yue Lu; Jong-Keun Son; Yurndong Jahng; Ying Li; Hyeun Wook Chang
Citreorosein inhibits degranulation and leukotriene C₄ generation through suppression of Syk pathway in mast cells.
Molecular and cellular biochemistry 2012;365(1-2):333-41.
2012: Ji-Hak Jeong; Yun-Jeong Jeong; jeong han kang; Hyeun Wook Chang; Hyun-Ji Cho; Il-Kyung Chung; Kwan-Kyu Park; Yoon-Yub Park; Jae-Moon Shin; Junji Magae
Ascochlorin inhibits growth factor-induced HIF-1α activation and tumor-angiogenesis through the suppression of EGFR/ERK/p70S6K signaling pathway in human cervical carcinoma cells.
Journal of cellular biochemistry 2012;113(4):1302-13.
2012: Hyun-Ji Cho; Il-Kyung Chung; Ji-Hak Jeong; Yun-Jeong Jeong; jeong han kang; Cheorl-Ho Kim; Hong-Tae Kim; Yong-Suk Moon; Kwan-Kyu Park; Yoon-Yub Park; Hyeun Wook Chang; Young-Chae Chang
Ascochlorin suppresses TGF-β1-induced PAI-1 expression through the inhibition of phospho-EGFR in rat kidney fibroblast cells.
Molecular biology reports 2012;39(4):4597-603.
2012: Seok-Jong Suh; Ho-Dong Yoon; Hyeun Wook Chang; Seung-Hak Cho; Tae-Wook Chung; Dong-Soo Kim; Yeon-Kye Kim; Choong-Hwan Kwak; Kyung-Min Kwon; Young-Choon Lee; Min Kyun Na; Sung-Jae Park; Jong-Keun Son; Kwon-Ho Song; Cheorl-Ho Kim
Triple inhibitory activity of Cliona celata against TNF-α-induced matrix metalloproteinase-9 production via downregulated NF-κB and AP-1, enzyme activity, and migration potential.
Inflammation 2012;35(2):736-45.
2012: Jing Lu Liang; Jong-Keun Son; Youngjoo Kwon; Seung Ho Lee; Hyo Chang Cha; Hyeun Wook Chang; Ji-Eun Eom; A. F. M. Motiur Rahman
A facile synthesis of emodin derivatives, emodin carbaldehyde, citreorosein, and their 10-deoxygenated derivatives and their inhibitory activities on μ-calpain.
Archives of pharmacal research 2012;35(3):447-54.
2012: Yue Lu; Makoto Murakami; Soon Jin Park; Jong-Keun Son; Seok-Jong Suh; Seung-Lark Hwang; Kyoung Hwangbo; Yurndong Jahng; Cheorl-Ho Kim; Seung Ho Lee; Xian Li; Ying Li; Hyeun Wook Chang
Citreorosein, a naturally occurring anthraquinone derivative isolated from Polygoni cuspidati radix, attenuates cyclooxygenase-2-dependent prostaglandin D2 generation by blocking Akt and JNK pathways in mouse bone marrow-derived mast cells.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2012;50(3-4):913-9.
2012: Seung-Lark Hwang; Jai-Youl Lee; Xian Li; Hyeun Wook Chang
Improved insulin sensitivity by rapamycin is associated with reduction of mTOR and S6K1 activities in L6 myotubes.
Biochemical and biophysical research communications 2012;418(2):402-7.
2012: Ye Jin; Jong Keun Son; Hyun Ok Yang; Hyeun Wook Chang
Pinusolide isolated from Biota orientalis inhibits 5-lipoxygenase dependent leukotriene C4 generation by blocking c-Jun N-terminal kinase pathway in mast cells.
Biological & pharmaceutical bulletin 2012;35(8):1374-8.
2012: Yue Lu; Makoto Murakami; Jong-Keun Son; Seok-Jong Suh; Meijuan Chi; Tae-Wook Chung; Kyoung Hwangbo; Yurngdong Jahng; Cheorl-Ho Kim; Choong-Hwan Kwak; Kyung-Min Kwon; Okyun Kwon; Xian Li; Jing Lu Liang; Hyeun Wook Chang
Citreorosein inhibits production of proinflammatory cytokines by blocking mitogen activated protein kinases, nuclear factor-κB and activator protein-1 activation in mouse bone marrow-derived mast cells.
Biological & pharmaceutical bulletin 2012;35(6):938-45.
2012: Xian Li; Yue Lu; Ju Hye Yang; Seung-Lark Hwang; Ye Jin; Hyeun Wook Chang
Natural vanadium-containing Jeju groundwater inhibits immunoglobulin E-mediated anaphylactic reaction and suppresses eicosanoid generation and degranulation in bone marrow derived-mast cells.
Biological & pharmaceutical bulletin 2012;35(2):216-22.
2012: Yue Lu; Sung-Soo Park; Young-Guk Park; Chang-Seob Seo; Jong-Keun Son; Seok-Jong Suh; Young-Chae Chang; Seung-Lark Hwang; Ye Jin; Cheorl-Ho Kim; Choong-Hwan Kwak; Kyung-Min Kwon; Okyun Kwon; Xian Li; Ying Li; Hyeun Wook Chang
Saucerneol F, a new lignan, inhibits iNOS expression via MAPKs, NF-κB and AP-1 inactivation in LPS-induced RAW264.7 cells.
International immunopharmacology 2012;12(1):175-81.
2012: Seung-Lark Hwang; Hyeun Wook Chang
Natural vanadium-containing Jeju ground water stimulates glucose uptake through the activation of AMP-activated protein kinase in L6 myotubes.
Molecular and cellular biochemistry 2012;360(1-2):401-9.
2011: Yue Lu; Makoto Murakami; Jong-Keun Son; Yoshitaka Taketomi; Ju Hye Yang; Young-Chae Chang; Seung-Lark Hwang; Kyoung Hwangbo; Cheorl-Ho Kim; Xian Li; Hyeun Wook Chang
Emodin, a naturally occurring anthraquinone derivative, suppresses IgE-mediated anaphylactic reaction and mast cell activation.
Biochemical pharmacology 2011;82(11):1700-8.
2011: Meihua Jin; Tae Hyung Jo; Chong-Kil Lee; Yue Lu; Sang-Jo Park; Young In Park; Kwang-Hee Son; Ju Hye Yang; Hyeun Wook Chang
Anti-inflammatory activity of 6-hydroxy-2,7-dimethoxy-1,4-henanthraquinone from tuberous roots of yam (Dioscorea batatas) through inhibition of prostaglandin D₂ and leukotriene C₄ production in mouse bone marrow-derived mast cells.
Archives of pharmacal research 2011;34(9):1495-501.
2011: Seok-Jong Suh; Hyun-Kwon Ko; Kwon-Ho Song; Jeong-Ran Kim; Kyung-Min Kwon; Young-Chae Chang; Young-Choon Lee; Dong-Soo Kim; Sung-Jae Park; Ju Hye Yang; Jong-Keun Son; Min-Kyun Na; Hyeun Wook Chang; Cheorl-Ho Kim
Ethylacetate fraction from Korean seaside starfish, Asterias amurensis, has an inhibitory effect on MMP-9 activity and expression and on migration behavior of TNF-α induced human aortic smooth muscle cells.
Toxicology in vitro : an international journal published in association with BIBRA 2011;25(4):767-73.
2011: Ju Hae Yang; Seok-Jong Suh; Yue Lu; Xian Li; Yeun-Kyung Lee; Young-Chae Chang; Min Kyun Na; Jung-Hye Choi; Cheorl-Ho Kim; Jong-Keun Son; Hyeun Wook Chang
Anti-inflammatory activity of ethylacetate fraction of Cliona celata.
Immunopharmacology and immunotoxicology 2011;33(2):373-9.
2011: Ji-Hak Jeong; jeong han kang; Seung-Lark Hwang; Hyun-Ji Cho; Kwan-Kyu Park; Yoon-Yup Park; Il-Kyung Chung; Hyeun Wook Chang; Cheorl-Ho Kim; Kwan-Sik Min; Hong-Duck Kim; Junji Magae; Shin-Sung Kang; Young-Chae Chang
4-O-methylascochlorin, methylated derivative of ascochlorin, stabilizes HIF-1α via AMPK activation.
Biochemical and biophysical research communications 2011;406(3):353-8.
2011: Su Jeong Kim; Okyun Kwon; Seung Ho Lee; Yue Lu; Chang-Seob Seo; Jong Keun Son; Young-Chae Chang; Kyoung Hwangbo; Cheorl-Ho Kim; Hyeun Wook Chang
Manassantin A isolated from Saururus chinensis inhibits 5-lipoxygenase-dependent leukotriene C4 generation by blocking mitogen-activated protein kinase activation in mast cells.
Biological & pharmaceutical bulletin 2011;34(11):1769-72.
2011: Meihua Jin; Kun Ho Son; Hyeun Wook Chang
Luteolin-7-O-glucoside suppresses leukotriene C(4) production and degranulation by inhibiting the phosphorylation of mitogen activated protein kinases and phospholipase Cγ1 in activated mouse bone marrow-derived mast cells.
Biological & pharmaceutical bulletin 2011;34(7):1032-6.
2011: Yue Lu; Sang-Jo Park; Jong-Keun Son; Kun Ho Son; Meihua Jin; Hyeun Wook Chang
Batatasin I, a naturally occurring phenanthrene derivative, isolated from tuberous roots of Dioscorea batatas suppresses eicosanoids generation and degranulation in bone marrow derived-mast cells.
Biological & pharmaceutical bulletin 2011;34(7):1021-5.
2011: Young Na Park; Youn Ju Lee; Jeon Hyeun Choi; Meihua Jin; Ju Hae Yang; Ying Li; Jiean Lee; Xian Li; Keuk Jun Kim; Jong Keun Son; Hyeun Wook Chang; Jong Yeon Kim; Eunkyung Lee
Alleviation of OVA-induced airway inflammation by flowers of Inula japonica in a murine model of asthma.
Bioscience, biotechnology, and biochemistry 2011;75(5):871-6.
2011: In Hyun Hwang; Dong Woo Kim; Su Jeong Kim; Byung Sun Min; Seung Ho Lee; Jong-Keun Son; Cheorl-Ho Kim; Hyeun Wook Chang; MinKyun Na
Asterosaponins isolated from the starfish Asterias amurensis.
Chemical & pharmaceutical bulletin 2011;59(1):78-83.
2010: Hyunmin Song; Sei-Ryang Oh; Hyeong-Kyu Lee; Gyoonhee Han; Joo-Heon Kim; Hyeun Wook Chang; Kyung-Eun Doh; Hee-Kyung Rhee; Hea-Young Park Choo
Synthesis and evaluation of benzoxazole derivatives as 5-lipoxygenase inhibitors.
Bioorganic & medicinal chemistry 2010;18(21):7580-5.
2010: Meihua Jin; Seok-Jong Suh; Ju Hye Yang; Yue Lu; Su Jeong Kim; Soonyoul Kwon; Tae Hyung Jo; Jin Wan Kim; Young In Park; Ghe Whan Ahn; Chong-Kil Lee; Cheorl-Ho Kim; Jong-Keun Son; Kun Ho Son; Hyeun Wook Chang
Anti-inflammatory activity of bark of Dioscorea batatas DECNE through the inhibition of iNOS and COX-2 expressions in RAW264.7 cells via NF-κB and ERK1/2 inactivation.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2010;48(11):3073-9.
2010: Zhejiu Quan; Youn Ju Lee; Ju Hye Yang; Yue Lu; Ying Li; Yeun-Kyung Lee; Meihua Jin; Jong-Yeon Kim; Joon Hyuk Choi; Jong-Keun Son; Hyeun Wook Chang
Ethanol extracts of Saururus chinensis suppress ovalbumin-sensitization airway inflammation.
Journal of ethnopharmacology 2010;132(1):143-9.
2010: Jeon Hyeun Choi; Young Na Park; Ying Li; Mei Hua Jin; Jiean Lee; Younju Lee; Jong Keun Son; Hyeun Wook Chang; Eunkyung Lee
Flowers of Inula japonica Attenuate Inflammatory Responses.
Immune network 2010;10(5):145-52.
2010: Ji-Hak Jeong; Shin-Sung Kang; Kwan-Kyu Park; Hyeun Wook Chang; Junji Magae; Young-Chae Chang
p53-independent induction of G1 arrest and p21WAF1/CIP1 expression by ascofuranone, an isoprenoid antibiotic, through downregulation of c-Myc.
Molecular cancer therapeutics 2010;9(7):2102-13.
2010: Seung-Lark Hwang; Hyeun Wook Chang; In-kyu Lee; Byung-Keun Yang; Junji Magae; Young-Chae Chang
Ascofuranone prevents ER stress-induced insulin resistance via activation of AMP-activated protein kinase in L6 myotube cells.
Biochemical and biophysical research communications 2010;396(4):967-72.
2010: Yue Lu; Tae Gyun Hong; Meihua Jin; Ju Hae Yang; Seok-Jong Suh; Dong Gen Piao; Hyun-Kwon Ko; Chang-Seob Seo; Young-Chae Chang; Cheorl-Ho Kim; Jong-Keun Son; Hyeun Wook Chang
Saucerneol G, a new lignan, from Saururus chinensis inhibits matrix metalloproteinase-9 induction via a nuclear factor κB and mitogen activated protein kinases in lipopolysaccharide-stimulated RAW264.7 cells.
Biological & pharmaceutical bulletin 2010;33(12):1944-8.
2010: Meihua Jin; Eunkyung Lee; Ju Hye Yang; Yue Lu; SangGu Kang; Young-Chae Chang; Seung Ho Lee; Seok-Jong Suh; Cheorl-Ho Kim; Hyeun Wook Chang
Deoxypodophyllotoxin inhibits the expression of intercellular adhesion molecule-1 induced by tumor necrosis factor-alpha in murine lung epithelial cells.
Biological & pharmaceutical bulletin 2010;33(1):1-5.
2009: Hyun Lim; Soo Bae Kim; Haeil Park; Hyeun Wook Chang; Hyun Pyo Kim
New anti-inflammatory synthetic biflavonoid with C-C (6-6") linkage: differential effects on cyclooxygenase-2 and inducible nitric oxide synthase.
Archives of pharmacal research 2009;32(11):1525-31.
2009: Meihua Jin; Ju Hye Yang; Eunkyung Lee; Yue Lu; Soonyoul Kwon; Kwang-Hee Son; Jong-Keun Son; Hyeun Wook Chang
Antiasthmatic activity of luteolin-7-O-glucoside from Ailanthus altissima through the downregulation of T helper 2 cytokine expression and inhibition of prostaglandin E2 production in an ovalbumin-induced asthma model.
Biological & pharmaceutical bulletin 2009;32(9):1500-3.
2009: Seok-Jong Suh; Jeong-Ran Kim; Un-Ho Jin; Hong-Seo Choi; Young-Chae Chang; Young-Choon Lee; Sung-Hoon Kim; In-Seon Lee; Tae Chul Moon; Hyeun Wook Chang; Cheorl-Ho Kim
Deoxypodophyllotoxin, flavolignan, from Anthriscus sylvestris Hoffm. inhibits migration and MMP-9 via MAPK pathways in TNF-alpha-induced HASMC.
Vascular pharmacology 2009;51(1):13-20.
2009: Ji-Hak Jeong; Hiroo Nakajima; Junji Magae; Chiharu Furukawa; Keiko Taki; Kensuke Otsuka; Masanori Tomita; In-Seon Lee; Cheorl-Ho Kim; Hyeun Wook Chang; Kwan-Sik Min; Kwan-Kyu Park; Kwan-Kyu Park; Young-Chae Chang
Ascochlorin activates p53 in a manner distinct from DNA damaging agents.
International journal of cancer. Journal international du cancer 2009;124(12):2797-803.
2009: Jeong-Ah Kim; Nam Seo Son; Jong-Keun Son; Yurngdong Jahng; Hyeun Wook Chang; Tae Su Jang; MinKyun Na; Seung-Ho Lee
Two new secoiridoid glycosides from the rhizomes of Gentiana scabra Bunge.
Archives of pharmacal research 2009;32(6):863-7.
2009: Haiyan Che; Byung Kyu Park; Hyun Lim; Hyun Pyo Kim; Hyeun Wook Chang; Jin-Hyun Jeong; Haeil Park
Synthesis of biflavones having a 6-O-7'' linkage and effects on cyclooxygenase-2 and inducible nitric oxide synthase.
Bioorganic & medicinal chemistry letters 2009;19(1):74-6.
2008: Hyun Lim; Kun Ho Son; Hyeun Wook Chang; Kihwan Bae; Sam Sik Kang; Hyun Pyo Kim
Anti-inflammatory activity of pectolinarigenin and pectolinarin isolated from Cirsium chanroenicum.
Biological & pharmaceutical bulletin 2008;31(11):2063-7.
2008: Chang-Seob Seo; Ming-Shan Zheng; Mi-Hee Woo; Chong-Soon Lee; Sung-Ho Lee; Byeong-Seon Jeong; Hyeun Wook Chang; Yurngdong Jahng; Eung Seok Lee; Jong-Keun Son
Lignans from the roots of Saururus chinensis.
Journal of natural products 2008;71(10):1771-4.
2008: Seok-Jong Suh; Kang Jin Cho; Tae Chul Moon; Hyeun Wook Chang; Young Guk Park; Cheorl-Ho Kim
3,4,5-trihydroxybenzaldehyde from Geum japonicum has dual inhibitory effect on matrix metalloproteinase 9; inhibition of gelatinoytic activity as well as MMP-9 expression in TNF-alpha induced HASMC.
Journal of cellular biochemistry 2008;105(2):524-33.
2008: Tae Chul Moon; Jin Cheul Kim; Seung-Eun Song; Seok-Jong Suh; Chang-Seob Seo; Youn Kyung Kim; Meihua Jin; Ju Hye Yang; Jong-Keun Son; Yurngdong Jahng; Cheorl-Ho Kim; Hyeun Wook Chang
Saucerneol D, a naturally occurring sesquilignan, inhibits LPS-induced iNOS expression in RAW264.7 cells by blocking NF-kappaB and MAPK activation.
International immunopharmacology 2008;8(10):1395-400.
2008: Eunkyung Lee; Meihua Jin; Zhejiu Quan; Nam Kyung Hwang; Chang Xin Lin; Sanggu Kang; Tae Chul Moon; Hyeun Wook Chang
Effect of dexamethasone on STAT6-dependent Ym1/2 expression in vivo and in vitro.
Biological & pharmaceutical bulletin 2008;31(9):1663-6.
2008: Meihua Jin; Tae Chul Moon; Zhejiu Quan; Eunkyung Lee; Yun Kyung Kim; Ju Hae Yang; Seok-Jong Suh; Tae Cheon Jeong; Seung Ho Lee; Cheorl-Ho Kim; Hyeun Wook Chang
The naturally occurring flavolignan, deoxypodophyllotoxin, inhibits lipopolysaccharide-induced iNOS expression through the NF-kappaB activation in RAW264.7 macrophage cells.
Biological & pharmaceutical bulletin 2008;31(7):1312-5.
2008: Hyeun Wook Chang; Kyoung Hwa Jang; Doohyun Lee; Hee Ryong Kang; Tae-Yoon Kim; Bong Ho Lee; Byoung Wook Choi; Sanghee Kim; Jongheon Shin
Monoglycerides from the brown alga Sargassum sagamianum: Isolation, synthesis, and biological activity.
Bioorganic & medicinal chemistry letters 2008;18(12):3589-92.
2008: Jin Mei Hua; Tae Chul Moon; Tae Gyun Hong; Kyong Min Park; Jong-Keun Son; Hyeun Wook Chang
5-Methoxy-8-(2-hydroxy-3-buthoxy-3-methylbutyloxy)-psoralen isolated from Angelica dahurica inhibits cyclooxygenase-2 and 5-lipoxygenase in mouse bone marrow-derived mast cells.
Archives of pharmacal research 2008;31(5):617-21.
2008: Tae Chul Moon; Chang-Seob Seo; Kyungmi Haa; Jin Cheul Kim; Nam Kyung Hwang; Tae Gyun Hong; Jee Hyeun Kim; Do Hun Kim; Jong-Keun Son; Hyeun Wook Chang
Meso-dihydroguaiaretic acid isolated from Saururus chinensis inhibits cyclooxygenase-2 and 5-lipoxygenase in mouse bone marrow-derived mast cells.
Archives of pharmacal research 2008;31(5):606-10.
2008: Ming Shan Zheng; Nam Kyung Hwang; Do Hoon Kim; Tae Chul Moon; Jong-Keun Son; Hyeun Wook Chang
Chemical constituents of Melandrium firmum Rohrbach and their anti-inflammatory activity.
Archives of pharmacal research 2008;31(3):318-22.
2008: Hyun Pyo Kim; Haeil Park; Kun Ho Son; Hyeun Wook Chang; Sam Sik Kang
Biochemical pharmacology of biflavonoids: implications for anti-inflammatory action.
Archives of pharmacal research 2008;31(3):265-73.
2008: Tae Chul Moon; Meihua Jin; Jong Keun Son; Hyeun Wook Chang
The effects of isoimperatorin isolated from Angelicae dahuricae on cyclooxygenase-2 and 5-lipoxygenase in mouse bone marrow-derived mast cells.
Archives of pharmacal research 2008;31(2):210-5.
2007: Tae Chul Moon; Zhejiu Quan; Jeongsoo Kim; Hyun Pyo Kim; Ichiro Kudo; Makodo Murakami; Haeil Park; Hyeun Wook Chang
Inhibitory effect of synthetic C-C biflavones on various phospholipase A(2)s activity.
Bioorganic & medicinal chemistry 2007;15(22):7138-43.
2007: Tae Chul Moon; So Young Son; Hyeun Wook Chang
Purification and characterization of 45 kDa PAF acetylhydrolase from bovine colostrum.
Biological & pharmaceutical bulletin 2007;30(9):1668-73.
2007: Sang Kyu Lee; Dong Ju Lee; Hemin Jeong; Sudeep R Bista; Mi Jeong Kang; Eung Seok Lee; Jong-Keun Son; Doo Hyun Nam; Hyeun Wook Chang; Seung Ho Lee; Yurngdong Jahng; Tae Cheon Jeong
Hepatotoxic and immunotoxic effects produced by 1,3-dibromopropane and its conjugation with glutathione in female BALB/c mice.
Journal of toxicology and environmental health. Part A 2007;70(15-16):1381-90.
2007: Yoshitaka Taketomi; Kohei Sunaga; Satoshi Tanaka; Masanori Nakamura; Satoru Arata; Tomohiko Okuda; Tae Chul Moon; Hyeun Wook Chang; Yukihiko Sugimoto; Koichi Kokame; Toshiyuki Miyata; Makoto Murakami; Ichiro Kudo
Impaired mast cell maturation and degranulation and attenuated allergic responses in Ndrg1-deficient mice.
Journal of immunology (Baltimore, Md. : 1950) 2007;178(11):7042-53.
2007: WenYi Jin; Phuong Thien Thuong; Nguyen Duy Su; Byung-Sun Min; Kwang-Hee Son; Hyeun Wook Chang; Hyun Pyo Kim; Sam Sik Kang; Dai-Eun Sok; KiHwan Bae
Antioxidant activity of cleomiscosins A and C isolated from Acer okamotoanum.
Archives of pharmacal research 2007;30(3):275-81.
2007: Ming-Lu Xu; Jae-Young Choi; Byeong-Seon Jeong; Gao Li; Kap-Rang Lee; Chong-Soon Lee; Mi-Hee Woo; Eung Seok Lee; Yurngdong Jahng; Hyeun Wook Chang; Seung-Ho Lee; Jong-Keun Son
Cytotoxic constituents isolated from the fruit bodies of Hypsizigus marmoreus.
Archives of pharmacal research 2007;30(1):28-33.
2006: Haeil Park; Young Hoon Kim; Hyeun Wook Chang; Hyun Pyo Kim
Anti-inflammatory activity of the synthetic C-C biflavonoids.
The Journal of pharmacy and pharmacology 2006;58(12):1661-7.
2006: Tae Chul Moon; Hwa-shin Hwang; Zhejiu Quan; Kwang-Hee Son; Cheorl-Ho Kim; Hyun Pyo Kim; Sam Sik Kang; Jong-Keun Son; Hyeun Wook Chang
Ochnaflavone, naturally occurring biflavonoid, inhibits phospholipase A2 dependent phosphatidylethanolamine degradation in a CCl4-induced rat liver microsome.
Biological & pharmaceutical bulletin 2006;29(12):2359-61.
2006: Seok-Jong Suh; Un-Ho Jin; Sung-Hoon Kim; Hyeun Wook Chang; Jong-Keun Son; Seung Ho Lee; Kwang-Hee Son; Cheorl-Ho Kim
Ochnaflavone inhibits TNF-alpha-induced human VSMC proliferation via regulation of cell cycle, ERK1/2, and MMP-9.
Journal of cellular biochemistry 2006;99(5):1298-307.
2006: Ming-Lu Xu; Ming Shan Zheng; Yeon-Kyong Lee; Dong-Cheul Moon; Chong-Soon Lee; Mi-Hee Woo; Byeong-Seon Jeong; Eung Seok Lee; Yurngdong Jahng; Hyeun Wook Chang; Seung-Ho Lee; Jong-Keun Son
A new stilbene glucoside from the roots of Polygonum multiflorum Thunb.
Archives of pharmacal research 2006;29(11):946-51.
2006: Se Jong Kim; Meihua Jin; Eunkyung Lee; Tae Chul Moon; Zhejiu Quan; Ju Hye Yang; Kwang-Hee Son; Kil-Ung Kim; Jong-Keun Son; Hyeun Wook Chang
Effects of methyl gallate on arachidonic acid metabolizing enzymes: Cyclooxygenase-2 and 5-lipoxygenase in mouse bone marrow-derived mast cells.
Archives of pharmacal research 2006;29(10):874-8.
2006: Ju Sun Kim; Jin Cheul Kim; Sang Hee Shim; Eun Ju Lee; WenYi Jin; KiHwan Bae; Kun Ho Son; Hyun Pyo Kim; Sam Sik Kang; Hyeun Wook Chang
Chemical constituents of the root of Dystaenia takeshimana and their anti-inflammatory activity.
Archives of pharmacal research 2006;29(8):617-23.
2006: Ming-Lu Xu; Gao Li; Dong-Cheul Moon; Chong-Soon Lee; Mi-Hee Woo; Eung Seok Lee; Yurngdong Jahng; Hyeun Wook Chang; Seung-Ho Lee; Jong-Keun Son
Cytotoxicity and DNA topoisomerase inhibitory activity of constituents isolated from the fruits of Evodia officinalis.
Archives of pharmacal research 2006;29(7):541-7.
2006: Chang Xiu Lin; Eunkyung Lee; Mei Hua Jin; Jumin Yook; Zhejiu Quan; Kyungmi Ha; Tae Chul Moon; Mi Jin Kim; Keuk Jun Kim; Seung Ho Lee; Hyeun Wook Chang
Deoxypodophyllotoxin (DPT) inhibits eosinophil recruitment into the airway and Th2 cytokine expression in an OVA-induced lung inflammation.
Planta medica 2006;72(9):786-91.
2006: Hyun Lim; Kun Ho Son; Hyeun Wook Chang; Sam Sik Kang; Hyun Pyo Kim
Inhibition of chronic skin inflammation by topical anti-inflammatory flavonoid preparation, Ato Formula.
Archives of pharmacal research 2006;29(6):503-7.
2006: Hyun Lim; Kun Ho Son; Hyeun Wook Chang; Sam Sik Kang; Hyun Pyo Kim
Effects of anti-inflammatory biflavonoid, ginkgetin, on chronic skin inflammation.
Biological & pharmaceutical bulletin 2006;29(5):1046-9.
2006: Mei Hua Jin; Jumin Yook; Eunkyung Lee; Chang Xiu Lin; Zhejiu Quan; Kwang-Hee Son; Ki Hwan Bae; Hyun Pyo Kim; Sam Sik Kang; Hyeun Wook Chang
Anti-inflammatory activity of Ailanthus altissima in ovalbumin-induced lung inflammation.
Biological & pharmaceutical bulletin 2006;29(5):884-8.
2006: Jianjun Chen; Hyeun Wook Chang; Hyun Pyo Kim; Haeil Park
Synthesis of phospholipase A2 inhibitory biflavonoids.
Bioorganic & medicinal chemistry letters 2006;16(9):2373-5.
2006: Min Jung Son; Tae Chul Moon; Eun Kyung Lee; Kwang-Hee Son; Hyun Pyo Kim; Sam Sik Kang; Jong-Keun Son; Seung Ho Lee; Hyeun Wook Chang
Naturally occurring biflavonoid, ochnaflavone, inhibits cyclooxygenases-2 and 5-lipoxygenase in mouse bone marrow-derived mast cells.
Archives of pharmacal research 2006;29(4):282-6.
2006: Seok-Jong Suh; Tae-Wook Chung; Min Jung Son; Sung-Hoon Kim; Tae Chul Moon; Kwang-Hee Son; Hyun Pyo Kim; Hyeun Wook Chang; Cheorl-Ho Kim
The naturally occurring biflavonoid, ochnaflavone, inhibits LPS-induced iNOS expression, which is mediated by ERK1/2 via NF-kappaB regulation, in RAW264.7 cells.
Archives of biochemistry and biophysics 2006;447(2):136-46.
2006: Eunkyung Lee; Kyungmi Haa; Jumin Yook; Mei Hua Jin; Chang-Seob Seo; Kwang-Hee Son; Hyun Pyo Kim; Ki Hwan Bae; Sam Sik Kang; Jong-Keun Son; Hyeun Wook Chang
Anti-asthmatic activity of an ethanol extract from Saururus chinensis.
Biological & pharmaceutical bulletin 2006;29(2):211-5.
2005: Jong-Keun Son; Min Jung Son; Eunkyung Lee; Tae Chul Moon; Kwang-Hee Son; Cheorl-Ho Kim; Hyun Pyo Kim; Sam Sik Kang; Hyeun Wook Chang
Ginkgetin, a Biflavone from Ginko biloba leaves, inhibits cyclooxygenases-2 and 5-lipoxygenase in mouse bone marrow-derived mast cells.
Biological & pharmaceutical bulletin 2005;28(12):2181-4.
2005: Eunkyung Lee; Jumin Yook; Kyungmi Haa; Hyeun Wook Chang
Induction of Ym1/2 in mouse bone marrow-derived mast cells by IL-4 and identification of Ym1/2 in connective tissue type-like mast cells derived from bone marrow cells cultured with IL-4 and stem cell factor.
Immunology and cell biology 2005;83(5):468-74.
2005: Chang-Kyun Han; Min Jung Son; Hyeun Wook Chang; Yeon Sook Chi; Haeil Park; Hyun Pyo Kim
Inhibition of prostaglandin production by a structurally-optimized flavonoid derivative, 2',4',7-trimethoxyflavone and cellular action mechanism.
Biological & pharmaceutical bulletin 2005;28(8):1366-70.
2005: Yong Hwan Choi; Kun Ho Son; Hyeun Wook Chang; KiHwan Bae; Sam Sik Kang; Hyun Pyo Kim
New anti-inflammatory formulation containing Synurus deltoides extract.
Archives of pharmacal research 2005;28(7):848-53.
2005: Ju Sun Kim; Sang Hee Shim; Sungwook Chae; Sang Jun Han; Sam Sik Kang; Kun Ho Son; Hyeun Wook Chang; Hyun Pyo Kim; KiHwan Bae
Saponins and other constituents from the leaves of Aralia elata.
Chemical & pharmaceutical bulletin 2005;53(6):696-700.
2005: Eunkyung Lee; Su Jeong Lee; Tae Yoon Lee; Hyeun Wook Chang
cDNA cloning and expression of biologically active platelet activating factor-acetylhydrolase (PAF-AH) from bovine mammary gland.
Biological & pharmaceutical bulletin 2005;28(4):580-3.
2005: Eunkyung Lee; Sang-Gu Kang; Hyeun Wook Chang
Identification of inducible genes during mast cell differentiation.
Archives of pharmacal research 2005;28(2):232-7.
2005: Nguyen Hai Dang; XinFeng Zhang; MingShan Zheng; Kwang-Hee Son; Hyeun Wook Chang; Hyun Pyo Kim; KiHwan Bae; Sam Sik Kang
Inhibitory constituents against cyclooxygenases from Aralia cordata Thunb.
Archives of pharmacal research 2005;28(1):28-33.
2005: Tae Chul Moon; Chang Xiu Lin; Joo Sang Lee; Dong Seon Kim; KiHwan Bae; Kwang-Hee Son; Hyun Pyo Kim; Sam Sik Kang; Jong-Keun Son; Hyeun Wook Chang
Antiinflammatory activity of astilbic acid from Astilbe chinensis.
Biological & pharmaceutical bulletin 2005;28(1):24-6.
2004: Tae Cheon Jeong; Hyeun Wook Chang; Eung Seok Lee; Tae Won Jeon; Hye Gwang Jeong; Michael P Holsapple
Skf 525-A induces cocaine N-demethylase, ethoxyresorufin O-deethylase, and pentoxyresorufin O-dealkylase activities by induction of cytochrome p-450 2B in female B6C3F1 mice.
Journal of toxicology and environmental health. Part A 2004;67(23-24):1955-70.
2004: Joon Hyun Park; Kun Ho Son; Sung Wan Kim; Hyeun Wook Chang; KiHwan Bae; Sam Sik Kang; Hyun Pyo Kim
Antiinflammatory activity of Synurus deltoides.
Phytotherapy research : PTR 2004;18(11):930-3.
2004: Nan Kyoung Lee; Kun Ho Son; Hyeun Wook Chang; Sam Sik Kang; Haeil Park; Moon Young Heo; Hyun Pyo Kim
Prenylated flavonoids as tyrosinase inhibitors.
Archives of pharmacal research 2004;27(11):1132-5.
2004: Hyun Pyo Kim; Kun Ho Son; Hyeun Wook Chang; Sam Sik Kang
Anti-inflammatory plant flavonoids and cellular action mechanisms.
Journal of pharmacological sciences 2004;96(3):229-45.
2004: Sang Kyu Lee; Nam Hee Kim; Jaeick Lee; Dong Hyun Kim; Eung Seok Lee; Han-Gon Choi; Hyeun Wook Chang; Yurngdong Jahng; Tae Cheon Jeong
Induction of cytochrome P450s by rutaecarpine and metabolism of rutaecarpine by cytochrome P450s.
Planta medica 2004;70(8):753-7.
2004: Gao Li; Chong-Soon Lee; Mi-Hee Woo; Seung-Ho Lee; Hyeun Wook Chang; Jong-Keun Son
Lignans from the bark of Machilus thunbergii and their DNA topoisomerases I and II inhibition and cytotoxicity.
Biological & pharmaceutical bulletin 2004;27(7):1147-50.
2004: Ji Hye Byun; Ju Sun Kim; Sam Sik Kang; Kun Ho Son; Hyeun Wook Chang; Hyun Pyo Kim; KiHwan Bae
Triterpenoid saponins from the roots of Sophora koreensis.
Chemical & pharmaceutical bulletin 2004;52(7):870-3.
2004: Seung Ho Lee; Min Jung Son; Hye Kyung Ju; Chang Xiu Lin; Tae Chul Moon; Han-Gon Choi; Jong-Keun Son; Hyeun Wook Chang
Dual inhibition of cyclooxygenases-2 and 5-lipoxygenase by deoxypodophyllotoxin in mouse bone marrow-derived mast cells.
Biological & pharmaceutical bulletin 2004;27(6):786-8.
2004: Ju Sun Kim; Sang Hee Shim; Yong Nan Xu; Sam Sik Kang; Kun Ho Son; Hyeun Wook Chang; Hyun Pyo Kim; KiHwan Bae
Phenolic glycosides from Pyrola japonica.
Chemical & pharmaceutical bulletin 2004;52(6):714-7.
2004: Yurngdong Jahng; Long Xuan Zhao; Yoon-Soo Moon; Arjun Basnet; Eun-kyung Kim; Hyeun Wook Chang; Hye Kyung Ju; Tae Cheon Jeong; Eung Seok Lee
Simple aromatic compounds containing propenone moiety show considerable dual COX/5-LOX inhibitory activities.
Bioorganic & medicinal chemistry letters 2004;14(10):2559-62.
2004: Eung Seok Lee; Hye Kyung Ju; Tae Chul Moon; Eunkyung Lee; Yurngdong Jahng; Sung Ho Lee; Jong-Keun Son; Suk-Hwan Baek; Hyeun Wook Chang
Inhibition of nitric oxide and tumor necrosis factor-alpha (TNF-alpha) production by propenone compound through blockade of nuclear factor (NF)-kappa B activation in cultured murine macrophages.
Biological & pharmaceutical bulletin 2004;27(5):617-20.
2004: Chang Xiu Lin; Min Jung Son; Hye Kyung Ju; Tae Chul Moon; Eunkyung Lee; So Hee Kim; Mi-Jeong Kim; Jong-Keun Son; Seung Ho Lee; Hyeun Wook Chang
Deoxypodophyllotoxin, a naturally occurring lignan, inhibits the passive cutaneous anaphylaxis reaction.
Planta medica 2004;70(5):474-6.
2004: Young-Ae Choi; Byung Rho Chin; Dong Hoon Rhee; Han-Gon Choi; Hyeun Wook Chang; Jung-Hye Kim; Suk-Hwan Baek
Methyl-beta-cyclodextrin inhibits cell growth and cell cycle arrest via a prostaglandin E(2) independent pathway.
Experimental & molecular medicine 2004;36(1):78-84.
2004: Dong Wook Kim; Kun Ho Son; Hyeun Wook Chang; KiHwan Bae; Sam Sik Kang; Hyun Pyo Kim
Anti-inflammatory activity of Sedum kamtschaticum.
Journal of ethnopharmacology 2004;90(2-3):409-14.
2003: Rei Kikuchi-Yanoshita; Yoshitaka Taketomi; Kumiko Koga; Toshihiko Sugiki; Yohei Atsumi; Takanori Saito; Shin-Ichi Ishii; Masato Hisada; Tamiko Suzuki-Nishimura; Masaatsu K Uchida; Tae Chul Moon; Hyeun Wook Chang; Masatsugu Sawada; Naoki Inagaki; Hiroichi Nagai; Makoto Murakami; Ichiro Kudo
Induction of PYPAF1 during in vitro maturation of mouse mast cells.
Journal of biochemistry 2003;134(5):699-709.
2003: Tae Chul Moon; Eunkyung Lee; Suk-Hwan Baek; Makoto Murakami; Ichiro Kudo; Nung-Soo Kim; Jong Myung Lee; Hae-Ki Min; Naotomo Kambe; Hyeun Wook Chang
Degranulation and cytokine expression in human cord blood-derived mast cells cultured in serum-free medium with recombinant human stem cell factor.
Molecules and cells 2003;16(2):154-60.
2003: Hye Kyung Ju; Tae Chul Moon; Eunkyung Lee; Suk-Hwan Baek; Ren-Bo An; KiHwan Bae; Kwang-Hee Son; Hyun Pyo Kim; Sam Sik Kang; Sung Ho Lee; Jong-Keun Son; Hyeun Wook Chang
Inhibitory effects of a new iridoid, patridoid II and its isomers, on nitric oxide and TNF-alpha production in cultured murine macrophages.
Planta medica 2003;69(10):950-3.
2003: Hye Kyung Ju; Suk-Hwan Baek; Ren-Bo An; KiHwan Bae; Kwang-Hee Son; Hyun Pyo Kim; Sam Sik Kang; Sung Ho Lee; Jong-Keun Son; Hyeun Wook Chang
Inhibitory effects of nardostachin on nitric oxide, prostaglandin E2, and tumor necrosis factor-alpha production in lipopolysaccharide activated macrophages.
Biological & pharmaceutical bulletin 2003;26(10):1375-8.
2003: Tae Chul Moon; Mi Suk Kim; Su Jeong Lee; Tae Yoon Lee; Soon Hak Kwon; Suk-Hwan Baek; Hyeun Wook Chang
Detection and characterization of 45 kDa platelet activating factor acetylhydrolase in cerebrospinal fluid of children with meningitis.
Archives of pharmacal research 2003;26(7):554-8.
2003: Yoshitaka Taketomi; Toshihiko Sugiki; Takanori Saito; Shin ichi Ishii; Masato Hisada; Tamiko Suzuki-Nishimura; Masaatsu K Uchida; Tae Chul Moon; Hyeun Wook Chang; Yasuhiro Natori; Shinobu Miyazawa; Rei Kikuchi-Yanoshita; Makoto Murakami; Ichiro Kudo
Identification of NDRG1 as an early inducible gene during in vitro maturation of cultured mast cells.
Biochemical and biophysical research communications 2003;306(2):339-46.
2003: Chul Soon Yong; Hongkee Sah; Yurngdong Jahng; Hyeun Wook Chang; Jong-Keun Son; Seung Ho Lee; Tae Cheon Jeong; Jong-Dal Rhee; Suk-Hwan Baek; Chong-Kook Kim; Han-Gon Choi
Physicochemical characterization of diclofenac sodium-loaded poloxamer gel as a rectal delivery system with fast absorption.
Drug development and industrial pharmacy 2003;29(5):545-53.
2003: Ren-Bo An; Byung-Sun Min; MinKyun Na; Hyeun Wook Chang; Kwang-Hee Son; Hyun Pyo Kim; Hyeong-Kyu Lee; KiHwan Bae; Sam Sik Kang
Iridoid esters from Patrinia saniculaefolia.
Chemical & pharmaceutical bulletin 2003;51(5):583-5.
2003: Dong Wook Kim; Kun Ho Son; Hyeun Wook Chang; KiHwan Bae; Sam Sik Kang; Hyun Pyo Kim
Anti-inflammatory activity of Elsholtzia splendens.
Archives of pharmacal research 2003;26(3):232-6.
2003: Wie-Jong Kwak; Tae Chul Moon; Chang Xiu Lin; Hyeun Gee Rhyn; Hyejin Jung; Eunkyung Lee; Dong-Yeul Kwon; Kwang-Hee Son; Hyun Pyo Kim; Sam Sik Kang; Makoto Murakami; Ichiro Kudo; Hyeun Wook Chang
Papyriflavonol A from Broussonetia papyrifera inhibits the passive cutaneous anaphylaxis reaction and has a secretory phospholipase A2-inhibitory activity.
Biological & pharmaceutical bulletin 2003;26(3):299-302.
2003: Wie-Jong Kwak; Chang-Kyun Han; Hyeun Wook Chang; Hyun Pyo Kim; Sam Sik Kang; Kwang-Hee Son
Loniceroside C, an antiinflammatory saponin from Lonicera japonica.
Chemical & pharmaceutical bulletin 2003;51(3):333-5.
2002: Sang Woo Yoo; Ju Sun Kim; Sam Sik Kang; Kun Ho Son; Hyeun Wook Chang; Hyun Pyo Kim; KiHwan Bae; Chong Ock Lee
Constituents of the fruits and leaves of Euodia daniellii.
Archives of pharmacal research 2002;25(6):824-30.
2002: Sung Young Kim; Tae Cheol Moon; Hyeun Wook Chang; Kun Ho Son; Sam Sik Kang; Hyun Pyo Kim
Effects of tanshinone I isolated from Salvia miltiorrhiza bunge on arachidonic acid metabolism and in vivo inflammatory responses.
Phytotherapy research : PTR 2002;16(7):616-20.
2002: Okyun Kwon; Eunkyung Lee; Tae Chul Moon; Hyejin Jung; Chang Xiu Lin; Kyung-Soo Nam; Suck Hwan Baek; Hae-Ki Min; Hyeun Wook Chang
Expression of cyclooxygenase-2 and pro-inflammatory cytokines induced by 2,2',4,4',5,5'-hexachlorobiphenyl (PCB 153) in human mast cells requires NF-kappa B activation.
Biological & pharmaceutical bulletin 2002;25(9):1165-8.
2002: Yun-Hee Shon; In-Kook Park; Il Soo Moon; Hyeun Wook Chang; In-Kyung Park; Kyung-Soo Nam
Effect of chitosan oligosaccharide on 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced oxidative stress in mice.
Biological & pharmaceutical bulletin 2002;25(9):1161-4.
2002: Yong Nan Xu; Ju Sun Kim; Sam Sik Kang; Kun Ho Son; Hyun Pyo Kim; Hyeun Wook Chang; KiHwan Bae
A new acylated triterpene from the roots of Chaenomeles japonica.
Chemical & pharmaceutical bulletin 2002;50(8):1124-5.
2002: Dong Wook Kim; Yeon Sook Chi; Kun Ho Son; Hyeun Wook Chang; Ju Sun Kim; Sam Sik Kang; Hyun Pyo Kim
Effects of sophoraflavanone G, a prenylated flavonoid from Sophora flavescens, on cyclooxygenase-2 and in vivo inflammatory response.
Archives of pharmacal research 2002;25(3):329-35.
2002: Hyeun Wook Chang; Soonhak Kwon; Hengmi Kim; Kunsoo Lee; Misuk Kim; Taechul Moon; Sukhwan Baek
Platelet-activating factor acetylhydrolase activity in cerebrospinal fluid of children with acute systemic or neurological illness.
Annals of neurology 2002;51(6):760-3.
2002: Makoto Murakami; Kumiko Yoshihara; Satoko Shimbara; Masatsugu Sawada; Naoki Inagaki; Hiroichi Nagai; Mikihiko Naito; Takashi Tsuruo; Tae Chul Moon; Hyeun Wook Chang; Ichiro Kudo
Group IID heparin-binding secretory phospholipase A(2) is expressed in human colon carcinoma cells and human mast cells and up-regulated in mouse inflammatory tissues.
European journal of biochemistry / FEBS 2002;269(11):2698-707.
2002: Wie-Jong Kwak; Chang-Kyun Han; Kwang-Hee Son; Hyeun Wook Chang; Sam Sik Kang; Byoung Kyu Park; Hyun Pyo Kim
Effects of Ginkgetin from Ginkgo biloba Leaves on cyclooxygenases and in vivo skin inflammation.
Planta medica 2002;68(4):316-21.
2002: Jeong-Hwa Choi; Hyeun Wook Chang; Soon-Jae Rhee
Effect of green tea catechin on arachidonic acid cascade in chronic cadmium-poisoned rats.
Asia Pacific journal of clinical nutrition 2002;11(4):292-7.
2001: Yeon Sook Chi; H G Jong; Kun Ho Son; Hyeun Wook Chang; Sam Sik Kang; Hyun Pyo Kim
Effects of naturally occurring prenylated flavonoids on enzymes metabolizing arachidonic acid: cyclooxygenases and lipoxygenases.
Biochemical pharmacology 2001;62(9):1185-91.
2001: Sam Sik Kang; Ju Sun Kim; K H Son; Hyun Pyo Kim; Hyeun Wook Chang
Cyclooxygenase-2 inhibitory cerebrosides from phytolaccae radix.
Chemical & pharmaceutical bulletin 2001;49(3):321-3.
2000: BS Cheon; Y H Kim; K S Son; Hyeun Wook Chang; Sam Sik Kang; Hyun Pyo Kim
Effects of prenylated flavonoids and biflavonoids on lipopolysaccharide-induced nitric oxide production from the mouse macrophage cell line RAW 264.7.
Planta medica 2000;66(7):596-600.
2000: Naotomo Kambe; M Kambe; Hyeun Wook Chang; A Matsui; Hae-Ki Min; M Hussein; C A Oskerizian; JP Kochan; A A Irani; Lawrence B Schwartz
An improved procedure for the development of human mast cells from dispersed fetal liver cells in serum-free culture medium.
Journal of immunological methods 2000;240(1-2):101-10.
2000: Suk-Hwan Baek; Taeg Kyu Kwon; J H Lim; Y J Lee; Hyeun Wook Chang; S J Lee; Jae-Hong Kim; KB Kwun
Secretory phospholipase A2-potentiated inducible nitric oxide synthase expression by macrophages requires NF-kappa B activation.
Journal of immunology (Baltimore, Md. : 1950) 2000;164(12):6359-65.
1999: Tae Chul Moon; M Murakami; I Kudo; Kwang-Hee Son; Hyun Pyo Kim; Sam Sik Kang; Hyeun Wook Chang
A new class of COX-2 inhibitor, rutaecarpine from Evodia rutaecarpa.
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 1999;48(12):621-5.
1999: Suk-Hwan Baek; S S Yun; Taeg Kyu Kwon; J R Kim; Hyeun Wook Chang; J Y Kwak; Jae-Hong Kim; KB Kwun
The effects of two new antagonists of secretory PLA2 on TNF, iNOS, and COX-2 expression in activated macrophages.
Shock (Augusta, Ga.) 1999;12(6):473-8.
1999: Carole A Oskeritzian; Z Wang; JP Kochan; Margaret M Grimes; Z Du; Hyeun Wook Chang; Steven Grant; Lawrence B Schwartz
Recombinant human (rh)IL-4-mediated apoptosis and recombinant human IL-6-mediated protection of recombinant human stem cell factor-dependent human mast cells derived from cord blood mononuclear cell progenitors.
Journal of immunology (Baltimore, Md. : 1950) 1999;163(9):5105-15.
1999: H H Kim; Jae Gyu Park; Tae Chul Moon; Hyeun Wook Chang; Yurngdong Jahng
Synthesis and biological acitivity of annulated pyrazoles as selective COX-2 inhibitors. I.
Archives of pharmacal research 1999;22(4):372-9.
1999: H K Kim; Kwang-Hee Son; Hyeun Wook Chang; Sam Sik Kang; Hyun Pyo Kim
Inhibition of rat adjuvant-induced arthritis by ginkgetin, a biflavone from ginkgo biloba leaves.
Planta medica 1999;65(5):465-7.
1999: S Y Kim; Kun Ho Son; Hyeun Wook Chang; Sam Sik Kang; Hyun Pyo Kim
Inhibition of mouse ear edema by steroidal and triterpenoid saponins.
Archives of pharmacal research 1999;22(3):313-6.
1999: K A Kim; Tae Chul Moon; Sung-Won Lee; K C Chung; B H Han; Hyeun Wook Chang
Pinusolide from the leaves of Biota orientalis as potent platelet activating factor antagonist.
Planta medica 1999;65(1):39-42.
1998: Hee Kee Kim; Kwang-Hee Son; Hyeun Wook Chang; Sam Sik Kang; Hyun Pyo Kim
Amentoflavone, a plant biflavone: a new potential anti-inflammatory agent.
Archives of pharmacal research 1998;21(4):406-10.
1998: K M You; K H Son; Hyeun Wook Chang; Sam Sik Kang; Hyun Pyo Kim
Vitexicarpin, a flavonoid from the fruits of Vitex rotundifolia, inhibits mouse lymphocyte proliferation and growth of cell lines in vitro.
Planta medica 1998;64(6):546-50.
1998: Tae Chul Moon; M Murakami; M D Ashraf; I Kudo; Hyeun Wook Chang
Regulation of cyclooxygenase-2 and endogenous cytokine expression by bacterial lipopolysaccharide that acts in synergy with c-kit ligand and Fc epsilon receptor I crosslinking in cultured mast cells.
Cellular immunology 1998;185(2):146-52.
1997: S J Lee; Kun Ho Son; Hyeun Wook Chang; Sam Sik Kang; Hyun Pyo Kim
Inhibition of arachidonate release from rat peritoneal macrophage by biflavonoids.
Archives of pharmacal research 1997;20(6):533-8.
1997: S Y Kim; Kwang-Hee Son; Hyeun Wook Chang; Sam Sik Kang; Hyun Pyo Kim
Inhibitory effects of plant extracts on adjuvant-induced arthritis.
Archives of pharmacal research 1997;20(4):313-7.
1996: Ryohei Yanoshita; Hyeun Wook Chang; K H Son; Ichiro Kudo; Yuji Samejima
Inhibition of lysoPAF acetyltransferase activity by flavonoids.
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 1996;45(11):546-9.
1994: Hyeun Wook Chang; S H Baek; K W Chung; Kwang-Hee Son; Hyun Pyo Kim; S S Kang
Inactivation of phospholipase A2 by naturally occurring biflavonoid, ochnaflavone.
Biochemical and biophysical research communications 1994;205(1):843-9.
1994: Kwang-Hee Son; KY Jung; Hyeun Wook Chang; Hyun Pyo Kim; Sam Sik Kang
Triterpenoid saponins from the aerial parts of Lonicera japonica.
Phytochemistry 1994;35(4):1005-8.
1989: S Hara; Ichiro Kudo; Hyeun Wook Chang; Kunio Matsuta; T Miyamoto; K Inoue
Purification and characterization of extracellular phospholipase A2 from human synovial fluid in rheumatoid arthritis.
Journal of biochemistry 1989;105(3):395-9.
1989: Ichiro Kudo; Hyeun Wook Chang; S Hara; Makoto Murakami; K Inoue
Characteristics and pathophysiological roles of extracellular phospholipase A2 in inflamed sites.
Dermatologica 1989;179 Suppl 1():72-6.
1988: Ryohei Yanoshita; Ichiro Kudo; Koichi Ikizawa; Hyeun Wook Chang; S Kobayashi; M Ohno; S Nojima; K Inoue
Hydrolysis of platelet activating factor and its methylated analogs by acetylhydrolases.
Journal of biochemistry 1988;103(5):815-9.
1988: Hyeun Wook Chang; K Inoue; A Bruni; E Boarato; G Toffano
Stereoselective effects of lysophosphatidylserine in rodents.
British journal of pharmacology 1988;93(3):647-53.
1987: Ichiro Kudo; S Nojima; Hyeun Wook Chang; Ryohei Yanoshita; H Hayashi; E Kondo; H Nomura; K Inoue
Antitumor activity of synthetic alkylphospholipids with or without PAF activity.
Lipids 1987;22(11):862-7.
1987: Hyeun Wook Chang; Ichiro Kudo; M Tomita; K Inoue
Purification and characterization of extracellular phospholipase A2 from peritoneal cavity of caseinate-treated rat.
Journal of biochemistry 1987;102(1):147-54.