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Jang-Yang Chang

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Sheng-Chieh Lien; Shu-Yi Wei; Jang-Yang Chang; Margaret Dah-Tsyr Chang; Shun-Fu Chang; Jeng-Jiann Chiu
Activation of PPAR-α induces cell cycle arrest and inhibits transforming growth factor-β1 induction of smooth muscle cell phenotype in 10T1/2 mesenchymal cells.
Ying-Yu Kuo; Hui-Ping Lin; Liang-Cheng Su; Horng-Dar Wang; Jonathan Yang; Jang-Yang Chang; Ya-Wen Chen; Hung-Che Chiang; Chi-Jung Chung; Ping-Hsuan Hsiao; Chieh Huo; Chih-Pin Chuu
Caffeic Acid Phenethyl Ester Suppresses Proliferation and Survival of TW2.6 Human Oral Cancer Cells via Inhibition of Akt Signaling.
Nai-Jung Chiang; Ching-Chuan Kuo; Ching-I Lin; Jing-Ping Liou; Chi-Yen Chang; Li-Tzong Chen; Jang-Yang Chang
A novel synthetic microtubule inhibitor, MPT0B214 exhibits antitumor activity in human tumor cells through mitochondria-dependent intrinsic pathway.

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2013: Sheng-Chieh Lien; Shu-Yi Wei; Jang-Yang Chang; Margaret Dah-Tsyr Chang; Shun-Fu Chang; Jeng-Jiann Chiu
Activation of PPAR-α induces cell cycle arrest and inhibits transforming growth factor-β1 induction of smooth muscle cell phenotype in 10T1/2 mesenchymal cells.
Cellular signalling 2013;25(5):1252-63.
2013: Ying-Yu Kuo; Hui-Ping Lin; Liang-Cheng Su; Horng-Dar Wang; Jonathan Yang; Jang-Yang Chang; Ya-Wen Chen; Hung-Che Chiang; Chi-Jung Chung; Ping-Hsuan Hsiao; Chieh Huo; Chih-Pin Chuu
Caffeic Acid Phenethyl Ester Suppresses Proliferation and Survival of TW2.6 Human Oral Cancer Cells via Inhibition of Akt Signaling.
International journal of molecular sciences 2013;14(5):8801-17.
2013: Nai-Jung Chiang; Ching-Chuan Kuo; Ching-I Lin; Jing-Ping Liou; Chi-Yen Chang; Li-Tzong Chen; Jang-Yang Chang
A novel synthetic microtubule inhibitor, MPT0B214 exhibits antitumor activity in human tumor cells through mitochondria-dependent intrinsic pathway.
PloS one 2013;8(3):e58953.
2013: Jenn-Ren Hsiao; Wei-Ting Hsueh; Cheng-Chih Huang; Jehn-Shyun Huang; Wei-Ting Lee; Chen-Lin Lin; Hung-I Lo; Chun-Yen Ou; Sen-Tien Tsai; Fang-Ting Wang; Yi-Hui Wang; Ya-Ling Weng; Tung-Yiu Wong; Shang-Yin Wu; Yuan-Hua Wu; Han-Chien Yang; Ming-Wei Yang; Chia-Jui Yen; Jang-Yang Chang; Kwang-Yu Chang; Ken-Chung Chen; Jeffrey S Chang
Allergies and risk of head and neck cancer: an original study plus meta-analysis.
PloS one 2013;8(2):e55138.
2012: Hsueh-Yun Lee; Lin-Wen Lee; Pen-Yuan Lin; Chi-Yen Chang; Jang-Yang Chang; Ching-Chuan Kuo; Chih-Ying Nien; Jing-Ping Liou
Application of Suzuki arylation, Sonogashira ethynylation and Rosenmund-von Braun cyanation in the exploration of substitution effects on the anticancer activity of 2-aroylquinolines.
Organic & biomolecular chemistry 2012;10(48):9593-600.
2012: Cheng-Chih Huang; Ying-Tai Jin; Ching-Chuan Kuo; Sen-Tien Tsai; Jeffrey S Chang; Jang-Yang Chang; Jenn-Ren Hsiao
Arginine deprivation as a new treatment strategy for head and neck cancer.
Oral oncology 2012;48(12):1227-35.
2012: Kuan-Der Lee; Mei-Yu Pai; Jang-Yang Chang; Chih-Cheng Chen; Li-Tzong Chen; Yao-Li Chen; Pei-Yi Chu; Shu-Huei Hsiao; Chia-Chen Hsu; Hui-Ming (Tim) Huang; Chia-Huei Lee; Yu-Wei Leu
Targeted Casp8AP2 methylation increases drug resistance in mesenchymal stem cells and cancer cells.
Biochemical and biophysical research communications 2012;422(4):578-85.
2012: Kuo-Li Chen; Chun Hei Antonio Cheung; Chien-Chang Huang; Ching-Chuan Kuo; Chang-Po Kuo; Chun-Cheng Lin; Ko-Jiunn Liu; Ching-Ming Wu; Yung-Ning Yang; Wun-Shaing Wayne Chang; Yi-Hsun Chang; Jang-Yang Chang
Targeting cathepsin S induces tumor cell autophagy via the EGFR-ERK signaling pathway.
Cancer letters 2012;317(1):89-98.
2011: Ching-Chuan Kuo; Jin-Fen Liu; Tsang-Wu Liu; Wen-Yu Pan; Her-Shyong Shiah; Ching-Ming Wu; Yun-Ning Yang; Kuo-Li Chen; Li-Tzong Chen; Shan-Na Chen; Yen-Ting Cheng; Jang-Yang Chang
Combination of arsenic trioxide and BCNU synergistically triggers redox-mediated autophagic cell death in human solid tumors.
Free radical biology & medicine 2011;51(12):2195-209.
2011: Hui-Ju Ch'ang; Jang-Yang Chang; Ming-Chu Chang; Jen-Shi Chen; Ann-Lii Cheng; Yen-Feng Chiu; Ruey-Kuen Hsieh; Chih-Hung Hsu; Tsann-Long Hwang; Pin-Wen Lin; Yu-Lin Lin; Yan-Shen Shan; Yu-Wen Tien; Hsiu-Po Wang; Jacqueline Whang-Peng; Li-Tzong Chen
Induction chemotherapy with gemcitabine, oxaliplatin, and 5-fluorouracil/leucovorin followed by concomitant chemoradiotherapy in patients with locally advanced pancreatic cancer: a Taiwan cooperative oncology group phase II study.
International journal of radiation oncology, biology, physics 2011;81(5):e749-57.
2011: Kwang-Yu Chang; Bin-Fay Chuang; Shan-Yin Tsai; Ching-Ming Wu; Chia-Jui Yen; Jang-Yang Chang
Novel phosphoinositide 3-kinase/mTOR dual inhibitor, NVP-BGT226, displays potent growth-inhibitory activity against human head and neck cancer cells in vitro and in vivo.
Clinical cancer research : an official journal of the American Association for Cancer Research 2011;17(22):7116-26.
2011: Chin-Lin Hsieh; Ching-Chuan Kuo; Tzong-Huei Lee; Ryh-Nan Pan; Mei-Huims Tseng; Jang-Yang Chang; Yueh-Hsiung Kuo
Novel terpenoids from Calocedrus macrolepis var. formosana.
Chemistry & biodiversity 2011;8(10):1901-7.
2011: Yung-Ning Yang; Ssu-Ching Yeh; Li-Tzong Chen; Yih-wen Chen; Chun Hei Antonio Cheung; Kai-ming Chou; Wen-Yu Pan; Tsui-Chun Tsou; Jang-Yang Chang
Enhancement of non-homologous end joining DNA repair capacity confers cancer cells resistance to the novel selenophene compound, D-501036.
Cancer letters 2011;309(1):110-8.
2011: Mei-Jung Lai; Hsueh-Yun Lee; Mei-Hsiang Lin; Chi-Yen Chang; Jang-Yang Chang; Hsing-Pang Hsieh; Ching-Chuan Kuo; Kuang-Shing Shey; Jian-Sung Wu; Su-Ying Wu; Jing-Ping Liou
Synthesis and biological evaluation of 1-(4'-Indolyl and 6'-Quinolinyl) indoles as a new class of potent anticancer agents.
European journal of medicinal chemistry 2011;46(9):3623-9.
2011: Huang-Hui Chen; Ting-Fang Chen; Yen-Ting Cheng; Wenchang Chiang; Ya-Lin Chien; Yueh-Hsiung Kuo; Ching-Kuo Lee; Ko-Jiunn Liu; Jang-Yang Chang; Ching-Chuan Kuo
Antimutagenic constituents of adlay (Coix lachryma-jobi L. var. ma-yuen Stapf) with potential cancer chemopreventive activity.
Journal of agricultural and food chemistry 2011;59(12):6444-52.
2011: Chun Hei Antonio Cheung; Mohane Coumar; Jang-Yang Chang; Hsing-Pang Hsieh
Aurora kinase inhibitor patents and agents in clinical testing: an update (2009-10).
Expert opinion on therapeutic patents 2011;21(6):857-84.
2011: Hsueh-Yun Lee; Jang-Yang Chang; Ling-Yin Chang; Wen-Yang Lai; Mei-Jung Lai; Kuang-Hsing Shih; Ching-Chuan Kuo; Chi-Yen Chang; Jing-Ping Liou
Concise syntheses of N-aryl-5,6,7-trimethoxyindoles as antimitotic and vascular disrupting agents: application of the copper-mediated Ullmann-type arylation.
Organic & biomolecular chemistry 2011;9(9):3154-7.
2011: Yen-Shih Tung; Mohane Coumar; Yu-Shan Wu; Hui-Yi Shiao; Jang-Yang Chang; Jing-Ping Liou; Paritosh Shukla; Chun-Wei Chang; Chi-Yen Chang; Ching-Chuan Kuo; Teng-Kuang Yeh; Chin-Yu Lin; Jian-Sung Wu; Su-Ying Wu; Chun-Chen Liao; Hsing-Pang Hsieh
Scaffold-hopping strategy: synthesis and biological evaluation of 5,6-fused bicyclic heteroaromatics to identify orally bioavailable anticancer agents.
Journal of medicinal chemistry 2011;54(8):3076-80.
2011: Hsun-Yueh Chuang; Jang-Yang Chang; Mei-Jung Lai; Ching-Chuan Kuo; Hsueh-Yun Lee; Hsing-Pang Hsieh; Ying-Jen Chen; Li-Tzong Chen; Wen-Yu Pan; Jing-Ping Liou
2-amino-3,4,5-trimethoxybenzophenones as potent tubulin polymerization inhibitors.
ChemMedChem 2011;6(3):450-6.
2011: Chun Hei Antonio Cheung; Mohane Coumar; Tzyh-Chyuan Hour; Hsing-Pang Hsieh; John Tsu-An Hsu; Shengkai Ko; Wen-Yang Lai; Tian-Ren Lee; Tzu-Wen Lien; Wen-Hsing Lin; Jin-Fen Liu; Hui-Yi Shiao; Teng-Kuang Yeh; Jang-Yang Chang
BPR1K653, a novel Aurora kinase inhibitor, exhibits potent anti-proliferative activity in MDR1 (P-gp170)-mediated multidrug-resistant cancer cells.
PloS one 2011;6(8):e23485.
2011: Cheng-Chih Hsieh; Hsueh-Yun Lee; Chih-Ying Nien; Ching-Chuan Kuo; Chi-Yen Chang; Jang-Yang Chang; Jing-Ping Liou
Synthesis and biological evaluation of 4-aroyl-6,7,8-trimethoxyquinolines as a novel class of anticancer agents.
Molecules (Basel, Switzerland) 2011;16(3):2274-84.
2011: Chun Hei Antonio Cheung; LiTing Cheng; Kwang-Yu Chang; Huang-Hui Chen; Jang-Yang Chang
Investigations of survivin: the past, present and future.
Frontiers in bioscience : a journal and virtual library 2011;16():952-61.
2011: Chih-Bo Hu; Ching-Ping Chen; Teng-Kuang Yeh; Jen-Shin Song; Chi-Yen Chang; Jiunn-Jye Chuu; Fei-Feng Tung; Pei-Yin Ho; Tung-Wei Chen; Chi-Hung Lin; Min-Hsien Wang; Kai-Yen Chang; Chen-Lung Huang; Heng-Liang Lin; Wen-Tai Li; Der-Ren Hwang; Jyh-Haur Chern; Ling-Ling Hwang; Jang-Yang Chang; Yu-Sheng Chao; Chiung-Tong Chen
BPR0C261 is a novel orally active antitumor agent with antimitotic and anti-angiogenic activities.
Cancer science 2011;102(1):182-91.
2010: Jrhau Lung; Ko-Jiunn Liu; Jang-Yang Chang; Sy-Jye Leu; Neng-Yao Shih
MBP-1 is efficiently encoded by an alternative transcript of the ENO1 gene but post-translationally regulated by proteasome-dependent protein turnover.
The FEBS journal 2010;277(20):4308-21.
2010: Cheng-Chi Chen; Jyh-Horng Wu; Ning-Sun Yang; Jang-Yang Chang; Ching-Chuan Kuo; Sheng-Yang Wang; Yueh-Hsiung Kuo
Cytotoxic C(35) terpenoid cryptotrione from the bark of Cryptomeria japonica.
Organic letters 2010;12(12):2786-9.
2010: Jo-Chun Chen; Biing-Jiun Uang; Ping-Chiang Lyu; Jang-Yang Chang; Ko-Jiunn Liu; Ching-Chuan Kuo; Hsing-Pang Hsieh; Hsin-Chieh Wang; Chao-Sheng Cheng; Yi-Hsun Chang; Margaret Dah-Tsyr Chang; Wun-Shaing Wayne Chang; Chun-Cheng Lin
Design and synthesis of alpha-ketoamides as cathepsin S inhibitors with potential applications against tumor invasion and angiogenesis.
Journal of medicinal chemistry 2010;53(11):4545-9.
2010: Cheng-Chih Hsieh; Yueh-Hsiung Kuo; Ching-Chuan Kuo; Li-Tzong Chen; Chun Hei Antonio Cheung; Tsu-Yi Chao; Chi-Hung Lin; Wen-Yu Pan; Chi-Yen Chang; Shih-Chang Chien; Tung-Wei Chen; Chia-Chi Lung; Jang-Yang Chang
Chamaecypanone C, a novel skeleton microtubule inhibitor, with anticancer activity by trigger caspase 8-Fas/FasL dependent apoptotic pathway in human cancer cells.
Biochemical pharmacology 2010;79(9):1261-71.
2010: Yu-Chu Wang; Yi-Shan Tsai; Jau-Ling Huang; Ka-Wo Lee; Ching-Chuan Kuo; Chung-Sheng Wang; A-Mei Huang; Jang-Yang Chang; Yuh-Jyh Jong; Chang-Shen Lin
Arecoline arrests cells at prometaphase by deregulating mitotic spindle assembly and spindle assembly checkpoint: implication for carcinogenesis.
Oral oncology 2010;46(4):255-62.
2010: Chih-Ying Nien; Yun-Ching Chen; Ching-Chuan Kuo; Hsing-Pang Hsieh; Chi-Yen Chang; Jian-Sung Wu; Su-Ying Wu; Jing-Ping Liou; Jang-Yang Chang
5-Amino-2-aroylquinolines as highly potent tubulin polymerization inhibitors.
Journal of medicinal chemistry 2010;53(5):2309-13.
2010: Yi-Ying Wu; Jang-Yang Chang; Tsu-Yi Chao
Paclitaxel and carboplatin-induced complete remission in peritoneal carcinomatosis of unknown origin: a report of two cases and review of the literature.
Tumori 2010;96(2):336-9.
2010: Teng-Kuang Yeh; Chien-Ming Li; Ching-Ping Chen; Jiuun-Jye Chuu; Chen-Lung Huang; Hsin-Sheng Wang; Chien-Chang Shen; Tien-Yi Lee; Chi-Yen Chang; Chung-Ming Chang; Yu-Sheng Chao; Chin-Tarng Lin; Jang-Yang Chang; Chiung-Tong Chen
Antitumor activities and pharmacokinetics of silatecans DB-67 and DB-91.
Pharmacological research : the official journal of the Italian Pharmacological Society 2010;61(2):108-15.
2010: Wei-Lun Huang; Hsuan-Heng Yeh; Chien-Chung Lin; Wu-Wei Lai; Jang-Yang Chang; Wen-Tsan Chang; Wu-Chou Su
Signal transducer and activator of transcription 3 activation up-regulates interleukin-6 autocrine production: a biochemical and genetic study of established cancer cell lines and clinical isolated human cancer cells.
Molecular cancer 2010;9():309.
2010: Chun Hei Antonio Cheung; Su-Ying Wu; Tian-Ren Lee; Chi-Yen Chang; Jian-Sung Wu; Hsing-Pang Hsieh; Jang-Yang Chang
Cancer cells acquire mitotic drug resistance properties through beta I-tubulin mutations and alterations in the expression of beta-tubulin isotypes.
PloS one 2010;5(9):e12564.
2010: Chun Hei Antonio Cheung; Huang-Hui Chen; Li-Ting Cheng; Kevin W Lyu; Jagat R Kanwar; Jang-Yang Chang
Targeting Hsp90 with small molecule inhibitors induces the over-expression of the anti-apoptotic molecule, survivin, in human A549, HONE-1 and HT-29 cancer cells.
Molecular cancer 2010;9():77.
2009: Li-Tzong Chen; Her-Shyong Shiah; Yee Chao; Jang-Yang Chang; Li-Ting Cheng; Jacqueline Whang-Peng
Alpha-fetoprotein response in advanced hepatocellular carcinoma receiving cytostatic agent.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2009;27(36):e271; author reply e272.
2009: Yu-Shan Wu; Mohane Coumar; Jang-Yang Chang; Hsu-Yi Sun; Fu-Ming Kuo; Ching-Chuan Kuo; Ying-Jun Chen; Chi-Yen Chang; Chia-Ling Hsiao; Jing-Ping Liou; Ching-Ping Chen; Hsien-Tsung Yao; Yi-Kun Chiang; Uan-Kang Tan; Chiung-Tong Chen; Chang-Ying Chu; Su-Ying Wu; Teng-Kuang Yeh; Chin-Yu Lin; Hsing-Pang Hsieh
Synthesis and evaluation of 3-aroylindoles as anticancer agents: metabolite approach.
Journal of medicinal chemistry 2009;52(15):4941-5.
2009: Yi-Kun Chiang; Ching-Chuan Kuo; Yu-Shan Wu; Chung-Tong Chen; Mohane Coumar; Jian-Sung Wu; Hsing-Pang Hsieh; Chi-Yen Chang; Huan-Yi Jseng; Ming-Hsine Wu; Jiun-Shyang Leou; Jen-Shin Song; Jang-Yang Chang; Ping-Chiang Lyu; Yu-Sheng Chao; Su-Ying Wu
Generation of ligand-based pharmacophore model and virtual screening for identification of novel tubulin inhibitors with potent anticancer activity.
Journal of medicinal chemistry 2009;52(14):4221-33.
2009: Kwang-Yu Chang; Jang-Yang Chang; Yun Yen
Increasing incidence of intrahepatic cholangiocarcinoma and its relationship to chronic viral hepatitis.
Journal of the National Comprehensive Cancer Network : JNCCN 2009;7(4):423-7.
2009: Chun Hei Antonio Cheung; Mohane Coumar; Hsing-Pang Hsieh; Jang-Yang Chang
Aurora kinase inhibitors in preclinical and clinical testing.
Expert opinion on investigational drugs 2009;18(4):379-98.
2009: Mei-Jung Lai; Ching-Chuan Kuo; Teng-Kuang Yeh; Hsing-Pang Hsieh; Li-Tzong Chen; Wen-Yu Pan; Kuang-Yang Hsu; Jang-Yang Chang; Jing-Ping Liou
Synthesis and structure-activity relationships of 1-benzyl-4,5,6-trimethoxyindoles as a novel class of potent antimitotic agents.
ChemMedChem 2009;4(4):588-93.
2009: Mohane Coumar; Chun Hei Antonio Cheung; Jang-Yang Chang; Hsing-Pang Hsieh
Advances in Aurora kinase inhibitor patents.
Expert opinion on therapeutic patents 2009;19(3):321-56.
2009: Chun Hei Antonio Cheung; Huang-Hui Chen; Ching-Chuan Kuo; Chi-Yen Chang; Mohane Coumar; Hsing-Pang Hsieh; Jang-Yang Chang
Survivin counteracts the therapeutic effect of microtubule de-stabilizers by stabilizing tubulin polymers.
Molecular cancer 2009;8():43.
2008: Yih-Wen Chen; James E Cleaver; Zafer Hatahet; Richard E Honkanen; Jang-Yang Chang; Yun Yen; Kai-Ming Chou
Human DNA polymerase eta activity and translocation is regulated by phosphorylation.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(43):16578-83.
2008: Kwang-Yu Chang; Jang-Yang Chang; Joseph Chao; Yun Yen
Modern staging and utility of PET imaging in esophageal cancer management.
Journal of the National Comprehensive Cancer Network : JNCCN 2008;6(9):862-9.
2008: Li-Chen Ma; Ching-Chuan Kuo; Jin-Fen Liu; Li-Tzong Chen; Jang-Yang Chang
Transcriptional repression of O6-methylguanine DNA methyltransferase gene rendering cells hypersensitive to N,N'-bis(2-chloroethyl)-N-nitrosurea in camptothecin-resistant cells.
Molecular pharmacology 2008;74(2):517-26.
2008: Jing-Ping Liou; Zi-Yi Wu; Ching-Chuan Kuo; Chi-Yen Chang; Pei-Yi Lu; Chi-Ming Chen; Hsing-Pang Hsieh; Jang-Yang Chang
Discovery of 4-amino and 4-hydroxy-1-aroylindoles as potent tubulin polymerization inhibitors.
Journal of medicinal chemistry 2008;51(14):4351-5.
2008: Yu-Hsun Kao; Hsing-Pang Hsieh; Santhosh Kumar Chitlimalla; Wen-Yu Pan; Ching-Chuan Kuo; Yuan-Chin Tsai; Wen-Hsing Lin; Shuang-En Chuang; Jang-Yang Chang
A novel peroxisome proliferator-activated receptor alpha/gamma agonist, BPR1H0101, inhibits topoisomerase II catalytic activity in human cancer cells.
Anti-cancer drugs 2008;19(2):151-8.
2007: Ching-Chuan Kuo; Jin-Fen Liu; Her-Shyong Shiah; Li-Chen Ma; Jang-Yang Chang
Tamoxifen accelerates proteasomal degradation of O6-methylguanine DNA methyltransferase in human cancer cells.
International journal of cancer. Journal international du cancer 2007;121(10):2293-300.
2007: Jing-Ping Liou; Kuo-Shun Hsu; Ching-Chuan Kuo; Chi-Yen Chang; Jang-Yang Chang
A novel oral indoline-sulfonamide agent, N-[1-(4-methoxybenzenesulfonyl)-2,3-dihydro-1H-indol-7-yl]-isonicotinamide (J30), exhibits potent activity against human cancer cells in vitro and in vivo through the disruption of microtubule.
The Journal of pharmacology and experimental therapeutics 2007;323(1):398-405.
2007: Jing-Ping Liou; Chang-Ying Wu; Hsing-Pang Hsieh; Chi-Yen Chang; Chi-Ming Chen; Ching-Chuan Kuo; Jang-Yang Chang
4- and 5-aroylindoles as novel classes of potent antitubulin agents.
Journal of medicinal chemistry 2007;50(18):4548-52.
2007: C-C Chen; Li-Tzong Chen; Tsui-Chun Tsou; Wen-Yu Pan; Ching-Chuan Kuo; Jin-Fen Liu; Szu Ching Yeh; Feng-Yuan Tsai; Hsing-Pang Hsieh; Jang-Yang Chang
Combined modalities of resistance in an oxaliplatin-resistant human gastric cancer cell line with enhanced sensitivity to 5-fluorouracil.
British journal of cancer 2007;97(3):334-44.
2007: Her-Shyong Shiah; Wan-Shu Lee; Shin-Hun Juang; Pao-Chiung Hong; Chia-Chi Lung; Ching-Jer Chang; Kai-Ming Chou; Jang-Yang Chang
Mitochondria-mediated and p53-associated apoptosis induced in human cancer cells by a novel selenophene derivative, D-501036.
Biochemical pharmacology 2007;73(5):610-9.
2007: Shin-Hun Juang; Chia-Chi Lung; Pi-Chen Hsu; Kuo-Shun Hsu; Yu-Chen Li; Pao-Chiung Hong; Her-Shyong Shiah; Ching-Chuan Kuo; Ching-Wei Huang; Yu-Chin Wang; Leeyuan Huang; Tom S Chen; Shyh-Fong Chen; Kuo-Chu Fu; Cheng-Li Hsu; Meng-Ju Lin; Ching-Jer Chang; Curtis L Ashendel; Thomas C K Chan; Kai-Ming Chou; Jang-Yang Chang
D-501036, a novel selenophene-based triheterocycle derivative, exhibits potent in vitro and in vivo antitumoral activity which involves DNA damage and ataxia telangiectasia-mutated nuclear protein kinase activation.
Molecular cancer therapeutics 2007;6(1):193-202.
2006: Jang-Yang Chang; Hsing-Pang Hsieh; Chi-Yen Chang; Kuo-Shun Hsu; Yi-Fang Chiang; Chi-Ming Chen; Ching-Chuan Kuo; Jing-Ping Liou
7-Aroyl-aminoindoline-1-sulfonamides as a novel class of potent antitubulin agents.
Journal of medicinal chemistry 2006;49(23):6656-9.
2006: Chin-Lin Hsieh; Mei-Huims Tseng; Yi-Yuan Shao; Jang-Yang Chang; Ching-Chuan Kuo; Chi-Yen Chang; Yueh-Hsiung Kuo
C35 terpenoids from the bark of Calocedrus macrolepis var. formosana with activity against human cancer cell lines.
Journal of natural products 2006;69(11):1611-3.
2006: Her-Shyong Shiah; Yee Chao; Li-Tzong Chen; Tzy-Jyun Yao; Jin-Ding Huang; Jang-Yang Chang; Pei-Jer Chen; Tsai-Rong Chuang; Yung-Hsin Chin; Jacqueline Whang-Peng; Tsang-Wu Liu
Phase I and pharmacokinetic study of oral thalidomide in patients with advanced hepatocellular carcinoma.
Cancer chemotherapy and pharmacology 2006;58(5):654-64.
2006: Jang-Yang Chang; Ming-Fang Yang; Chi-Yen Chang; Chi-Ming Chen; Ching-Chuan Kuo; Jing-Ping Liou
2-amino and 2'-aminocombretastatin derivatives as potent antimitotic agents.
Journal of medicinal chemistry 2006;49(21):6412-5.
2006: Jing-Ping Liou; Neeraj Mahindroo; Chun-Wei Chang; Fu-Ming Guo; Sandy Wen-Hsing Lee; Uan-Kang Tan; Teng-Kuang Yeh; Ching-Chuan Kuo; Yi-Wei Chang; Ping-Hsun Lu; Yen-Shih Tung; Ke-Ta Lin; Jang-Yang Chang; Hsing-Pang Hsieh
Structure-activity relationship studies of 3-aroylindoles as potent antimitotic agents.
ChemMedChem 2006;1(10):1106-18.
2006: Yi-Lin Chen; Shinn-Zong Lin; Jang-Yang Chang; Yeung-Leung Cheng; Nu-Man Tsai; Shee-Ping Chen; Wen-Liang Chang; Horng-Jyh Harn
In vitro and in vivo studies of a novel potential anticancer agent of isochaihulactone on human lung cancer A549 cells.
Biochemical pharmacology 2006;72(3):308-19.
2006: Hui-Ju Ch'ang; Chuan-Cheng Wang; Ann-Lii Cheng; Chiun Hsu; Yen-Shen Lu; Ming-Chu Chang; Jaw-Town Lin; Hsiu-Po Wang; Her-Shyong Shiah; Tsang-Wu Liu; Jang-Yang Chang; Jacqueline Whang-Peng; Li-Tzong Chen
Phase I study of biweekly gemcitabine followed by oxaliplatin and simplified 48-h infusion of fluorouracil/leucovorin for advanced pancreatic cancer.
Journal of gastroenterology and hepatology 2006;21(5):874-9.
2006: Her-Shyong Shiah; Ann-Lii Cheng; Chiun Hsu; Chih-Hung Hsu; Tsang-Wu Liu; Jang-Yang Chang; Chang-Ming Jan; Yee Chao; Wei-Lan Yu; Tsai-Rong Chuang; Jacqueline Whang-Peng; Li-Tzong Chen
Phase I-II trial of weekly gemcitabine plus high-dose 5-fluorouracil and leucovorin in advanced pancreatic cancer.
Journal of gastroenterology and hepatology 2006;21(3):531-6.
2006: Ching-Chuan Kuo; Jin-Fen Liu; Jang-Yang Chang
DNA repair enzyme, O6-methylguanine DNA methyltransferase, modulates cytotoxicity of camptothecin-derived topoisomerase I inhibitors.
The Journal of pharmacology and experimental therapeutics 2006;316(2):946-54.
2006: Siu-Keung Tse; Jang-Yang Chang; Wei-Lun Su; Shein-Chung Chow; Chao Hsiung; Qingshu Lu
Statistical quality control process for traditional Chinese medicine.
Journal of biopharmaceutical statistics 2006;16(6):861-74.
2006: Chuan-Cheng Wang; Jang-Yang Chang; Tsang-Wu Liu; Chin-Yu Lin; Yu-Chieh Yu; Ruey-Long Hong
Phase II study of gemcitabine plus vinorelbine in the treatment of cisplatin-resistant nasopharyngeal carcinoma.
Head & neck 2006;28(1):74-80.
2005: Her-Shyong Shiah; Tsang-Wu Liu; Li-Tzong Chen; Jang-Yang Chang; Jacqueline Ming Liu; Tsai-Rong Chuang; W-S Lee; Jacqueline Whang-Peng
Pulmonary embolism after transcatheter arterial chemoembolization.
European journal of cancer care 2005;14(5):440-2.
2005: Valeriy A Bacherikov; Jang-Yang Chang; Yi-Wen Lin; Ching-Huang Chen; Wen-Yu Pan; Huajin Dong; Rong-Zau Lee; Ting-Chao Chou; Tsann-Long Su
Synthesis and antitumor activity of 5-(9-acridinylamino)anisidine derivatives.
Bioorganic & medicinal chemistry 2005;13(23):6513-20.
2005: Chung-Huang Chan; Tsang-Wu Liu; Li-Tzong Chen; Jang-Yang Chang; Jacqueline Whang-Peng
Long-term complete remission of metastatic gastric cancer after weekly docetaxel, 24 h infusion of high-dose 5-FU/leucovorin and cisplatin.
Journal of gastroenterology and hepatology 2005;20(9):1470-1.
2005: Li-Tzong Chen; Tsang-Wu Liu; Yee Chao; Her-Shyong Shiah; Jang-Yang Chang; Shin-Hun Juang; S-C Chen; Tsai-Rong Chuang; Yung-Hsin Chin; Jacqueline Whang-Peng
alpha-fetoprotein response predicts survival benefits of thalidomide in advanced hepatocellular carcinoma.
Alimentary pharmacology & therapeutics 2005;22(3):217-26.
2005: Yi-Ming Chiang; Jang-Yang Chang; Ching-Chuan Kuo; Chi-Yen Chang; Yueh-Hsiung Kuo
Cytotoxic triterpenes from the aerial roots of Ficus microcarpa.
Phytochemistry 2005;66(4):495-501.
2005: Chi-I Chang; Jang-Yang Chang; Ching-Chuan Kuo; Wen-Yu Pan; Yueh-Hsiung Kuo
Four new 6-nor5(6-->7)abeo-abietane type diterpenes and antitumoral cytotoxic diterpene constituents from the bark of Taiwania cryptomerioides.
Planta medica 2005;71(1):72-6.
2004: Jing-Ping Liou; Yi-Ling Chang; Fu-Ming Kuo; Chun-Wei Chang; Huan-Yi Tseng; Chiung-Chiu Wang; Yung-Ning Yang; Jang-Yang Chang; Shiow-Ju Lee; Hsing-Pang Hsieh
Concise synthesis and structure-activity relationships of combretastatin A-4 analogues, 1-aroylindoles and 3-aroylindoles, as novel classes of potent antitubulin agents.
Journal of medicinal chemistry 2004;47(17):4247-57.
2004: Shin-Hun Juang; Wen-Yu Pan; Ching-Chuan Kuo; Jing-Ping Liou; Yi-Mei Hung; Li-Tzong Chen; Hsing-Pang Hsieh; Jang-Yang Chang
A novel bis-benzylidenecyclopentanone derivative, BPR0Y007, inducing a rapid caspase activation involving upregulation of Fas (CD95/APO-1) and wild-type p53 in human oral epidermoid carcinoma cells.
Biochemical pharmacology 2004;68(2):293-303.
2004: Ching-Chuan Kuo; Hsing-Pang Hsieh; Wen-Yu Pan; Ching-Ping Chen; Jing-Ping Liou; Shiow-Ju Lee; Yi-Ling Chang; Li-Tzong Chen; Chiung-Tong Chen; Jang-Yang Chang
BPR0L075, a novel synthetic indole compound with antimitotic activity in human cancer cells, exerts effective antitumoral activity in vivo.
Cancer research 2004;64(13):4621-8.
2004: Jing-Ping Liou; Jang-Yang Chang; Chun-Wei Chang; Chi-Yen Chang; Neeraj Mahindroo; Fu-Ming Kuo; Hsing-Pang Hsieh
Synthesis and structure-activity relationships of 3-aminobenzophenones as antimitotic agents.
Journal of medicinal chemistry 2004;47(11):2897-905.
2004: Jang-Yang Chang; Wann-Shen Ka; Tsu-Yi Chao; Tsang-Wu Liu; Tsai-Rong Chuang; Li-Tzong Chen
Hepatocellular carcinoma with intra-atrial tumor thrombi. A report of three cases responsive to thalidomide treatment and literature review.
Oncology 2004;67(3-4):320-6.
2004: Chi-I Chang; Ching-Chuan Kuo; Jang-Yang Chang; Yueh-Hsiung Kuo
Three new oleanane-type triterpenes from Ludwigia octovalvis with cytotoxic activity against two human cancer cell lines.
Journal of natural products 2004;67(1):91-3.
2004: Jang-Yang Chang; Chi-Yen Chang; Ching-Chuan Kuo; Li-Tzong Chen; Yung-Shung Wein; Yueh-Hsiung Kuo
Salvinal, a novel microtubule inhibitor isolated from Salvia miltiorrhizae Bunge (Danshen), with antimitotic activity in multidrug-sensitive and -resistant human tumor cells.
Molecular pharmacology 2004;65(1):77-84.
2003: Jang-Yang Chang; Chyun-Feng Lin; Wen-Yu Pan; Valeriy A Bacherikov; Ting-Chao Chou; Ching-Huang Chen; Huajin Dong; Shu-Yun Cheng; Tsong-Jen Tasi; Yi-Wen Lin; Kuo-Tung Chen; Li-Tzong Chen; Tsann-Long Su
New analogues of AHMA as potential antitumor agents: synthesis and biological activity.
Bioorganic & medicinal chemistry 2003;11(23):4959-69.
2003: Jang-Yang Chang; Hsing-Pang Hsieh; Wen-Yu Pan; Jing-Ping Liou; Shian-Jy Bey; Li-Tzong Chen; Jin-Fen Liu; Jen-Shin Song
Dual inhibition of topoisomerase I and tubulin polymerization by BPR0Y007, a novel cytotoxic agent.
Biochemical pharmacology 2003;65(12):2009-19.
2003: Hsing-Pang Hsieh; Jing-Ping Liou; Ying-Ting Lin; Neeraj Mahindroo; Jang-Yang Chang; Yung-Ning Yang; Shuenn-Shing Chern; Uan-Kang Tan; Chun-Wei Chang; Tung-Wei Chen; Chi-Hung Lin; Ying-Ying Chang; Chiung-Chiu Wang
Structure-activity and crystallographic analysis of benzophenone derivatives-the potential anticancer agents.
Bioorganic & medicinal chemistry letters 2003;13(1):101-5.
2002: Ching-Chuan Kuo; Wenchang Chiang; Guey-Ping Liu; Ya-Lin Chien; Jang-Yang Chang; Ching-Kuo Lee; Jir-Mehng Lo; Shou-Ling Huang; Ming-Chih Shih; Yueh-Hsiung Kuo
2,2'-Diphenyl-1-picrylhydrazyl radical-scavenging active components from adlay (Coix lachryma-jobi L. var. ma-yuen Stapf) hulls.
Journal of agricultural and food chemistry 2002;50(21):5850-5.
2002: Kamesh Rastogi; Jang-Yang Chang; Wen-Yu Pan; Ching-Huang Chen; Ting-Chao Chou; Li-Tzong Chen; Tsann-Long Su
Antitumor AHMA linked to DNA minor groove binding agents: synthesis and biological evaluation.
Journal of medicinal chemistry 2002;45(20):4485-93.
2002: Kuan-Der Lee; Tsang-Wu Liu; Cheng-Wen Wu; C-M Tiu; Jacqueline Ming Liu; Tsai-Rong Chung; Jang-Yang Chang; Jacqueline Whang-Peng; Li-Tzong Chen
Non-surgical treatment for afferent loop syndrome in recurrent gastric cancer complicated by peritoneal carcinomatosis: percutaneous transhepatic duodenal drainage followed by 24-hour infusion of high-dose fluorouracil and leucovorin.
Annals of oncology : official journal of the European Society for Medical Oncology / ESMO 2002;13(7):1151-5.
2002: Jang-Yang Chang; Jin-Fen Liu; Shin-Hun Juang; Tsang-Wu Liu; Li-Tzong Chen
Novel mutation of topoisomerase I in rendering cells resistant to camptothecin.
Cancer research 2002;62(13):3716-21.
2002: Jacqueline Ming Liu; Li-Tzong Chen; Yee Chao; Anna Fen-Yau Li; Cheng-Wen Wu; Tai-Shun Liu; Her-Shyong Shiah; Jang-Yang Chang; Jong Dong Chen; Hsiao Wei Wu; Wei Chun Lin; Chieh Lan; Jacqueline Whang-Peng
Phase II and pharmacokinetic study of GL331 in previously treated Chinese gastric cancer patients.
Cancer chemotherapy and pharmacology 2002;49(5):425-8.
2002: Li-Tzong Chen; Tsang-Wu Liu; Cheng-Wen Wu; Tsai-Rong Chung; Her-Shyong Shiah; Chang-Ming Jan; Jacqueline Ming Liu; Jacqueline Whang-Peng; Jang-Yang Chang
A phase I study of weekly docetaxel, 24-hour infusion of high-dose fluorouracil/leucovorin and cisplatin in patients with advanced gastric cancer.
Oncology 2002;63(3):239-47.