FIND

researchers

DISCOVER

relevant articles

PROMOTE

your research

now for free

Thomas Chang

Research Profile

Chemicals & Drugs

Anatomy

Living Beings

Phenomena

Concepts & Ideas

Drug Dose Response Relationship

Procedures

High Pressure Liquid Chromatography

Co-author Network

Publications

TOP 3
Devinder Sharma; Matthew A Sherman; Aik Jiang Lau; Thomas K H Chang
Agonism of human pregnane X receptor by rilpivirine and etravirine: Comparison with first generation non-nucleoside reverse transcriptase inhibitors.
Aik Jiang Lau; Rajaraman Ganesh; Guixiang Yang; Christie C Baucom; Thomas K H Chang
Evaluation of Ginkgo biloba extract as an activator of human glucocorticoid receptor.
Jayakumar Surendradoss; Thomas K H Chang; Frank S Abbott
Assessment of the role of in situ generated (E)-2,4-diene-valproic acid in the toxicity of valproic acid and (E)-2-ene-valproic acid in sandwich-cultured rat hepatocytes.

Register for free to view:

Visualized networks:

See your personal network in
sophisticated graphical views

GeoTargeted Searches:

Locate experts around the world
and connect with global collaborators

Research Profiles:

See the research activity
of experts around the globe

Geonetwork of Thomas Chang (preview)

Cities where this author has publications
Cities where co-authors of this author have publications

Flash Player Required

All Publications

2013: Devinder Sharma; Matthew A Sherman; Aik Jiang Lau; Thomas K H Chang
Agonism of human pregnane X receptor by rilpivirine and etravirine: Comparison with first generation non-nucleoside reverse transcriptase inhibitors.
Biochemical pharmacology 2013;85(11):1700-11.
2013: Aik Jiang Lau; Rajaraman Ganesh; Guixiang Yang; Christie C Baucom; Thomas K H Chang
Evaluation of Ginkgo biloba extract as an activator of human glucocorticoid receptor.
Journal of ethnopharmacology 2013;145(2):670-5.
2012: Jayakumar Surendradoss; Thomas K H Chang; Frank S Abbott
Assessment of the role of in situ generated (E)-2,4-diene-valproic acid in the toxicity of valproic acid and (E)-2-ene-valproic acid in sandwich-cultured rat hepatocytes.
Toxicology and applied pharmacology 2012;264(3):413-22.
2012: Aik Jiang Lau; Guixiang Yang; Chun Wei Yap; Thomas K H Chang
Selective agonism of human pregnane X receptor by individual ginkgolides.
Drug metabolism and disposition: the biological fate of chemicals 2012;40(6):1113-21.
2011: Subrata Deb; Grace S Leung; Jenny K Tai; Thomas K H Chang; Stelvio M Bandiera
Estradiol-mediated suppression of CYP1B1 expression in mouse MA-10 Leydig cells is independent of protein kinase A and estrogen receptor.
Molecular and cellular biochemistry 2011;358(1-2):387-95.
2011: Aik Jiang Lau; Guixiang Yang; Thomas K H Chang
Isoform-selective activation of human constitutive androstane receptor by Ginkgo biloba extract: functional analysis of the SV23, SV24, and SV25 splice variants.
The Journal of pharmacology and experimental therapeutics 2011;339(2):704-15.
2011: Tony K L Kiang; Xiao Wei Teng; Jayakumar Surendradoss; Stoyan Karagiozov; Frank S Abbott; Thomas K H Chang
Glutathione depletion by valproic acid in sandwich-cultured rat hepatocytes: Role of biotransformation and temporal relationship with onset of toxicity.
Toxicology and applied pharmacology 2011;252(3):318-24.
2011: Aik Jiang Lau; Guixiang Yang; Rajaraman Ganesh; Christie C Baucom; Thomas K H Chang
Differential effect of meclizine on the activity of human pregnane X receptor and constitutive androstane receptor.
The Journal of pharmacology and experimental therapeutics 2011;336(3):816-26.
2010: Tony K L Kiang; Xiao Wei Teng; Stoyan Karagiozov; Jayakumar Surendradoss; Thomas K H Chang; Frank S Abbott
Role of oxidative metabolism in the effect of valproic acid on markers of cell viability, necrosis, and oxidative stress in sandwich-cultured rat hepatocytes.
Toxicological sciences : an official journal of the Society of Toxicology 2010;118(2):501-9.
2010: Aik Jiang Lau; Guixiang Yang; Rajaraman Ganesh; Christie C Baucom; Thomas K H Chang
Human pregnane X receptor agonism by Ginkgo biloba extract: assessment of the role of individual ginkgolides.
The Journal of pharmacology and experimental therapeutics 2010;335(3):771-80.
2010: Thomas K H Chang; Jie Chen; Guixiang Yang; Eugene Y H Yeung
Inhibition of procarcinogen-bioactivating human CYP1A1, CYP1A2 and CYP1B1 enzymes by melatonin.
Journal of pineal research 2010;48(1):55-64.
2009: Rajaraman Ganesh; Guixiang Yang; Jie Chen; Thomas K H Chang
Modulation of CYP1B1 and CYP1A1 gene expression and activation of aryl hydrocarbon receptor by Ginkgo biloba extract in MCF-10A human mammary epithelial cells.
Canadian journal of physiology and pharmacology 2009;87(9):674-83.
2009: Thomas K H Chang
Activation of pregnane X receptor (PXR) and constitutive androstane receptor (CAR) by herbal medicines.
The AAPS journal 2009;11(3):590-601.
2009: Aik Jiang Lau; Thomas K H Chang
Inhibition of human CYP2B6-catalyzed bupropion hydroxylation by Ginkgo biloba extract: effect of terpene trilactones and flavonols.
Drug metabolism and disposition: the biological fate of chemicals 2009;37(9):1931-7.
2009: Grace S Leung; M Kawai; Jenny K Tai; Jie Chen; Stelvio M Bandiera; Thomas K H Chang
Developmental expression and endocrine regulation of CYP1B1 in rat testis.
Drug metabolism and disposition: the biological fate of chemicals 2009;37(3):523-8.
2008: Eugene Y H Yeung; Tatsuya Sueyoshi; Masahiko Negishi; Thomas K H Chang
Identification of Ginkgo biloba as a novel activator of pregnane X receptor.
Drug metabolism and disposition: the biological fate of chemicals 2008;36(11):2270-6.
2007: Andrew M Numa; Frank S Abbott; Thomas K H Chang
Effect of Ginkgo biloba extract on oxidative metabolism of valproic acid in hepatic microsomes from donors with the CYP2C9*1/*1 genotype.
Canadian journal of physiology and pharmacology 2007;85(9):848-55.
2007: Thomas K H Chang; Jie Chen; Chia-Ting Yu
In vitro inhibition of rat CYP1A1 and CYP1A2 by piceatannol, a hydroxylated metabolite of trans-resveratrol.
Drug metabolism letters 2007;1(1):13-6.
2007: Mohammad M Rahman; Shahrzad Elmi; Thomas K H Chang; Ni Bai; Nada A Sallam; Virginia S Lemos; Farzad Moien-Afshari; Ismail Laher
Increased vascular contractility in isolated vessels from cigarette smoking rats is mediated by basal endothelin release.
Vascular pharmacology 2007;46(1):35-42.
2006: Rajaraman Ganesh; Jie Chen; Thomas K H Chang
Ginkgolide A contributes to the potentiation of acetaminophen toxicity by Ginkgo biloba extract in primary cultures of rat hepatocytes.
Toxicology and applied pharmacology 2006;217(2):225-33.
2006: Tony K L Kiang; Ping C Ho; M Reza Anari; Vincent Tong; Frank S Abbott; Thomas K H Chang
Contribution of CYP2C9, CYP2A6, and CYP2B6 to valproic acid metabolism in hepatic microsomes from individuals with the CYP2C9*1/*1 genotype.
Toxicological sciences : an official journal of the Society of Toxicology 2006;94(2):261-71.
2006: Aspasia Michoulas; Vincent Tong; Xiao Wei Teng; Thomas K H Chang; Frank S Abbott; Kevin Farrell
Oxidative stress in children receiving valproic acid.
The Journal of pediatrics 2006;149(5):692-6.
2006: Thomas K H Chang; Jie Chen; Eugene Y H Yeung
Effect of Ginkgo biloba extract on procarcinogen-bioactivating human CYP1 enzymes: identification of isorhamnetin, kaempferol, and quercetin as potent inhibitors of CYP1B1.
Toxicology and applied pharmacology 2006;213(1):18-26.
2006: Thomas K H Chang; Jie Chen; Xiao Wei Teng
Distinct role of bilobalide and ginkgolide A in the modulation of rat CYP2B1 and CYP3A23 gene expression by Ginkgo biloba extract in cultured hepatocytes.
Drug metabolism and disposition: the biological fate of chemicals 2006;34(2):234-42.
2006: Thomas K H Chang; Frank S Abbott
Oxidative stress as a mechanism of valproic acid-associated hepatotoxicity.
Drug metabolism reviews 2006;38(4):627-39.
2006: David J Waxman; Thomas K H Chang
Use of 7-ethoxycoumarin to monitor multiple enzymes in the human CYP1, CYP2, and CYP3 families.
Methods in molecular biology (Clifton, N.J.) 2006;320():153-6.
2006: David J Waxman; Thomas K H Chang
An isocratic high-performance liquid chromatography assay for CYP7A1-catalyzed cholesterol 7alpha-hydroxylation.
Methods in molecular biology (Clifton, N.J.) 2006;320():149-52.
2006: Charles L Crespi; Thomas K H Chang; David J Waxman
Determination of CYP4A11-catalyzed lauric acid 12-hydroxylation by high-performance liquid chromatography with radiometric detection.
Methods in molecular biology (Clifton, N.J.) 2006;320():143-7.
2006: David J Waxman; Thomas K H Chang
Thin-layer chromatography analysis of human CYP3A-catalyzed testosterone 6beta-hydroxylation.
Methods in molecular biology (Clifton, N.J.) 2006;320():133-41.
2006: Thomas K H Chang; Charles L Crespi; David J Waxman
Spectrophotometric analysis of human CYP2E1-catalyzed p-nitrophenol hydroxylation.
Methods in molecular biology (Clifton, N.J.) 2006;320():127-31.
2006: Charles L Crespi; Thomas K H Chang; David J Waxman
CYP2D6-dependent bufuralol 1'-hydroxylation assayed by reverse-phase ion-pair high-performance liquid chromatography with fluorescence detection.
Methods in molecular biology (Clifton, N.J.) 2006;320():121-5.
2006: Charles L Crespi; Thomas K H Chang; David J Waxman
CYP2C19-mediated (S)-mephenytoin 4'-hydroxylation assayed by high-performance liquid chromatography with radiometric detection.
Methods in molecular biology (Clifton, N.J.) 2006;320():115-9.
2006: Charles L Crespi; Thomas K H Chang; David J Waxman
Determination of CYP2C9-catalyzed diclofenac 4'-hydroxylation by high-performance liquid chromatography.
Methods in molecular biology (Clifton, N.J.) 2006;320():109-13.
2006: Charles L Crespi; Thomas K H Chang; David J Waxman
High-performance liquid chromatography analysis of CYP2C8-catalyzed paclitaxel 6alpha-hydroxylation.
Methods in molecular biology (Clifton, N.J.) 2006;320():103-7.
2006: Thomas K H Chang; Charles L Crespi; David J Waxman
Determination of CYP2B6 component of 7-ethoxy-4-trifluoromethylcoumarin O-deethylation activity in human liver microsomes.
Methods in molecular biology (Clifton, N.J.) 2006;320():97-102.
2006: David J Waxman; Thomas K H Chang
Spectrofluorometric analysis of CYP2A6-catalyzed coumarin 7-hydroxylation.
Methods in molecular biology (Clifton, N.J.) 2006;320():91-6.
2006: Thomas K H Chang; David J Waxman
Enzymatic analysis of cDNA-expressed human CYP1A1, CYP1A2, and CYP1B1 with 7-ethoxyresorufin as substrate.
Methods in molecular biology (Clifton, N.J.) 2006;320():85-90.
2006: Thomas K H Chang; David J Waxman
Catalytic assays for human cytochrome P450: an introduction.
Methods in molecular biology (Clifton, N.J.) 2006;320():73-83.
2006: Thomas K H Chang; David J Waxman
Synthetic drugs and natural products as modulators of constitutive androstane receptor (CAR) and pregnane X receptor (PXR).
Drug metabolism reviews 2006;38(1-2):51-73.
2005: Vincent Tong; Xiao Wei Teng; Thomas K H Chang; Frank S Abbott
Valproic acid I: time course of lipid peroxidation biomarkers, liver toxicity, and valproic acid metabolite levels in rats.
Toxicological sciences : an official journal of the Society of Toxicology 2005;86(2):427-35.
2005: Vincent Tong; Xiao Wei Teng; Thomas K H Chang; Frank S Abbott
Valproic acid II: effects on oxidative stress, mitochondrial membrane potential, and cytotoxicity in glutathione-depleted rat hepatocytes.
Toxicological sciences : an official journal of the Society of Toxicology 2005;86(2):436-43.
2005: Vincent Tong; Xiao Wei Teng; Stoyan Karagiozov; Thomas K H Chang; Frank S Abbott
Valproic acid glucuronidation is associated with increases in 15-F2t-isoprostane in rats.
Free radical biology & medicine 2005;38(11):1471-83.
2005: Tony K L Kiang; Mary H H Ensom; Thomas K H Chang
UDP-glucuronosyltransferases and clinical drug-drug interactions.
Pharmacology & therapeutics 2005;106(1):97-132.
2005: Thomas K H Chang; David J Waxman
Pregnane X receptor-mediated transcription.
Methods in enzymology 2005;400():588-98.
2005: Chia-Ting Yu; Jie Chen; Xiao Wei Teng; Vincent Tong; Thomas K H Chang
Lack of evidence for induction of CYP2B1, CYP3A23, and CYP1A2 gene expression by Panax ginseng and Panax quinquefolius extracts in adult rats and primary cultures of rat hepatocytes.
Drug metabolism and disposition: the biological fate of chemicals 2005;33(1):19-22.
2004: Maria Madeira; Marc Levine; Thomas K H Chang; Ali Mirfazaelian; Gail D Bellward
The effect of cimetidine on dextromethorphan O-demethylase activity of human liver microsomes and recombinant CYP2D6.
Drug metabolism and disposition: the biological fate of chemicals 2004;32(4):460-7.
2004: Salete Benetton; V M Borges; Thomas K H Chang; Keith M McErlane
Role of individual human cytochrome P450 enzymes in the in vitro metabolism of hydromorphone.
Xenobiotica; the fate of foreign compounds in biological systems 2004;34(4):335-44.
2004: Catherine Y S Cheung; Jie Chen; Thomas K H Chang
Evaluation of a real-time polymerase chain reaction method for the quantification of CYP1B1 gene expression in MCF-7 human breast carcinoma cells.
Journal of pharmacological and toxicological methods 2004;49(2):97-104.
2004: I Fan Kuo; Jie Chen; Thomas K H Chang
Effect of Ginkgo biloba extract on rat hepatic microsomal CYP1A activity: role of ginkgolides, bilobalide, and flavonols.
Canadian journal of physiology and pharmacology 2004;82(1):57-64.
2003: Masahiko Kawai; Jie Chen; Catherine Y S Cheung; Thomas K H Chang
Transcript profiling of cytochrome P450 genes in HL-60 human leukemic cells: upregulation of CYP1B1 by all-trans-retinoic acid.
Molecular and cellular biochemistry 2003;248(1-2):57-65.
2003: Vincent Tong; Thomas K H Chang; Jie Chen; Frank S Abbott
The effect of valproic acid on hepatic and plasma levels of 15-F2t-isoprostane in rats.
Free radical biology & medicine 2003;34(11):1435-46.
2003: P C Ho; Frank S Abbott; Uli Zanger; Thomas K H Chang
Influence of CYP2C9 genotypes on the formation of a hepatotoxic metabolite of valproic acid in human liver microsomes.
The pharmacogenomics journal 2003;3(6):335-42.
2003: Zhengyuan Xia; David V Godin; Thomas K H Chang; David M Ansley
Dose-dependent protection of cardiac function by propofol during ischemia and early reperfusion in rats: effects on 15-F2t-isoprostane formation.
Canadian journal of physiology and pharmacology 2003;81(1):14-21.
2003: Thomas K H Chang; Jie Chen; Vincent Pillay; Jeong-Yau Ho; Stelvio M Bandiera
Real-time polymerase chain reaction analysis of CYP1B1 gene expression in human liver.
Toxicological sciences : an official journal of the Society of Toxicology 2003;71(1):11-9.
2003: Thomas K H Chang; Stelvio M Bandiera; Jie Chen
Constitutive androstane receptor and pregnane X receptor gene expression in human liver: interindividual variability and correlation with CYP2B6 mRNA levels.
Drug metabolism and disposition: the biological fate of chemicals 2003;31(1):7-10.
2002: Thomas K H Chang; Jie Chen; Salete Benetton
In vitro effect of standardized ginseng extracts and individual ginsenosides on the catalytic activity of human CYP1A1, CYP1A2, and CYP1B1.
Drug metabolism and disposition: the biological fate of chemicals 2002;30(4):378-84.
2001: Thomas K H Chang; Jie Chen; W B Lee
Differential inhibition and inactivation of human CYP1 enzymes by trans-resveratrol: evidence for mechanism-based inactivation of CYP1A2.
The Journal of pharmacology and experimental therapeutics 2001;299(3):874-82.
2001: Z Xu; M Kawai; Stelvio M Bandiera; Thomas K H Chang
Influence of dietary zinc deficiency during development on hepatic CYP2C11, CYP2C12, CYP3A2, CYP3A9, and CYP3A18 expression in postpubertal male rats.
Biochemical pharmacology 2001;62(9):1283-91.
2001: M Kawai; Stelvio M Bandiera; Thomas K H Chang; Gail D Bellward
Effect of exogenous growth hormone on somatic growth, gonadal development, and hepatic CYP2C11 and CYP2C12 expression in prepubertal intact male rats.
Canadian journal of physiology and pharmacology 2001;79(4):352-61.
2001: Thomas K H Chang; R K Yeung
Effect of trans-resveratrol on 7-benzyloxy-4-trifluoromethylcoumarin O-dealkylation catalyzed by human recombinant CYP3A4 and CYP3A5.
Canadian journal of physiology and pharmacology 2001;79(3):220-6.
2000: Thomas K H Chang; W B Lee; Hin Hin Ko
Trans-resveratrol modulates the catalytic activity and mRNA expression of the procarcinogen-activating human cytochrome P450 1B1.
Canadian journal of physiology and pharmacology 2000;78(11):874-81.
2000: M Kawai; Stelvio M Bandiera; Thomas K H Chang; Gail D Bellward
Growth hormone regulation and developmental expression of rat hepatic CYP3A18, CYP3A9, and CYP3A2.
Biochemical pharmacology 2000;59(10):1277-87.
1999: M Kawai; Stelvio M Bandiera; Thomas K H Chang; Frederique M Poulet; Paul M Vancutsem; Gail D Bellward
Modulation of hepatic CYP2A1, CYP2C11, and CYP3A9 expression in adult rats by neonatal administration of tamoxifen.
Drug metabolism and disposition: the biological fate of chemicals 1999;27(12):1392-8.
1998: M D Anderson; Stelvio M Bandiera; Thomas K H Chang; Gail D Bellward
Effect of androgen administration during puberty on hepatic CYP2C11, CYP3A, and CYP2A1 expression in adult female rats.
Drug metabolism and disposition: the biological fate of chemicals 1998;26(10):1031-8.
1998: Marc Levine; E Y Law; Stelvio M Bandiera; Thomas K H Chang; Gail D Bellward
In vivo cimetidine inhibits hepatic CYP2C6 and CYP2C11 but not CYP1A1 in adult male rats.
The Journal of pharmacology and experimental therapeutics 1998;284(2):493-9.
1998: David J Waxman; Thomas K H Chang
Use of 7-ethoxycoumarin to monitor multiple enzymes in the human CYP1, CYP2, and CYP3 families.
Methods in molecular biology (Clifton, N.J.) 1998;107():175-9.
1998: David J Waxman; Thomas K H Chang
An isocratic high-performance liquid chromatographic assay for CYP7A1-catalyzed cholesterol 7 alpha-hydroxylation.
Methods in molecular biology (Clifton, N.J.) 1998;107():169-73.
1998: David J Waxman; Thomas K H Chang
Thin-layer chromatographic analysis of human CYP3A-catalyzed testosterone 6 beta-hydroxylation.
Methods in molecular biology (Clifton, N.J.) 1998;107():153-61.
1998: Thomas K H Chang; Charles L Crespi; David J Waxman
Spectrophotometric analysis of human CYP2E1-catalyzed p-nitrophenol hydroxylation.
Methods in molecular biology (Clifton, N.J.) 1998;107():147-52.
1998: Thomas K H Chang; Charles L Crespi; David J Waxman
Determination of the CYP2B6 component of 7-ethoxy-4-trifluoromethylcoumarin O-deethylation activity in human liver microsomes.
Methods in molecular biology (Clifton, N.J.) 1998;107():117-22.
1998: David J Waxman; Thomas K H Chang
Spectrofluorometric analysis of CYP2A6-catalyzed coumarin 7-hydroxylation.
Methods in molecular biology (Clifton, N.J.) 1998;107():111-6.
1998: Thomas K H Chang; David J Waxman
Enzymatic analysis of cDNA-expressed human CYP1A1, CYP1A2, and CYP1B1 with 7-ethoxyresorufin as substrate.
Methods in molecular biology (Clifton, N.J.) 1998;107():103-9.
1998: Thomas K H Chang; David J Waxman
Catalytic assays for human cytochrome P450.
Methods in molecular biology (Clifton, N.J.) 1998;107():95-102.
1997: Thomas K H Chang; M D Anderson; Stelvio M Bandiera; Gail D Bellward
Effect of ovariectomy and androgen on phenobarbital induction of hepatic CYP2B1 and CYP2B2 in Sprague-Dawley rats.
Drug metabolism and disposition: the biological fate of chemicals 1997;25(8):994-1000.
1997: Thomas K H Chang; L Yu; J A Goldstein; David J Waxman
Identification of the polymorphically expressed CYP2C19 and the wild-type CYP2C9-ILE359 allele as low-Km catalysts of cyclophosphamide and ifosfamide activation.
Pharmacogenetics 1997;7(3):211-21.
1997: Thomas K H Chang; L Yu; P Maurel; David J Waxman
Enhanced cyclophosphamide and ifosfamide activation in primary human hepatocyte cultures: response to cytochrome P-450 inducers and autoinduction by oxazaphosphorines.
Cancer research 1997;57(10):1946-54.