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Keith Channon

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Craig A Lygate; Debra J Medway; Dunja Aksentijevic; Robert S Balaban; Keith M Channon; Kieran Clarke; Dana Dawson; Joseph P de Bono; Imre Hunyor; Darci Phillips; Liam Sebag-Montefiore; Michiel ten Hove; Hugh Watkins; Sevasti Zervou; Stefan Neubauer
Living without creatine: unchanged exercise capacity and response to chronic myocardial infarction in creatine-deficient mice.
Regent Lee; David Adlam; Charalambos Antoniades; Robin P Choudhury; Janet E Digby; Rajesh K Kharbanda; Keith M Channon
Heparin administration leads to rapid decrease in plasma matrix metalloproteinase-9.
Asif J Iqbal; Theodore S Kapellos; Amy Kenyon; Eileen McNeill; Daniel Regan-Komito; Lewis Taylor; Gemma E White; Keith M Channon; Ivy Christou; Edward A Fisher; David R Greaves
A real time chemotaxis assay unveils unique migratory profiles amongst different primary murine macrophages.

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2013: Craig A Lygate; Debra J Medway; Dunja Aksentijevic; Robert S Balaban; Keith M Channon; Kieran Clarke; Dana Dawson; Joseph P de Bono; Imre Hunyor; Darci Phillips; Liam Sebag-Montefiore; Michiel ten Hove; Hugh Watkins; Sevasti Zervou; Stefan Neubauer
Living without creatine: unchanged exercise capacity and response to chronic myocardial infarction in creatine-deficient mice.
Circulation research 2013;112(6):945-55.
2013: Regent Lee; David Adlam; Charalambos Antoniades; Robin P Choudhury; Janet E Digby; Rajesh K Kharbanda; Keith M Channon
Heparin administration leads to rapid decrease in plasma matrix metalloproteinase-9.
International journal of cardiology 2013;163(2):212-3.
2013: Asif J Iqbal; Theodore S Kapellos; Amy Kenyon; Eileen McNeill; Daniel Regan-Komito; Lewis Taylor; Gemma E White; Keith M Channon; Ivy Christou; Edward A Fisher; David R Greaves
A real time chemotaxis assay unveils unique migratory profiles amongst different primary murine macrophages.
PloS one 2013;8(3):e58744.
2012: Keith M Channon
Tetrahydrobiopterin: a vascular redox target to improve endothelial function.
Current vascular pharmacology 2012;10(6):705-8.
2012: Ricardo Carnicer; Nicholas J Alp; Jennifer K Bendall; Keith M Channon; Mark Crabtree; Ashley B Hale; Gregory B S Lim; Xing Liu; Svetlana Reilly; Silvia Suffredini; Nicoletta C Surdo; Mei Hua Zhang; Barbara Casadei
Cardiomyocyte GTP cyclohydrolase 1 and tetrahydrobiopterin increase NOS1 activity and accelerate myocardial relaxation.
Circulation research 2012;111(6):718-27.
2012: Martina A. McAteer; Hannah B Nugent; Neil Ruparelia; Jürgen E Schneider; Lee-Anne Stork; Keith M Channon; Andrew Jefferson; Kulveer Mankia; Robin P Choudhury
A leukocyte-mimetic magnetic resonance imaging contrast agent homes rapidly to activated endothelium and tracks with atherosclerotic lesion macrophage content.
Arteriosclerosis, thrombosis, and vascular biology 2012;32(6):1427-35.
2012: Regent Lee; Colin A Clelland; David Adlam; Keith M Channon
Lines of Zahn in coronary artery thrombus.
European heart journal 2012;33(9):1039.
2012: Marios Margaritis; Keith M Channon; Charalambos Antoniades
Statins and vein graft failure in coronary bypass surgery.
Current opinion in pharmacology 2012;12(2):172-80.
2012: Gillian Douglas; Ashley B Hale; Amy L Tatham; Jennifer K Bendall; Emma E Carter; Mark J Crabtree; Keith M Channon
Endothelial-specific Nox2 overexpression increases vascular superoxide and macrophage recruitment in ApoE⁻/⁻ mice.
Cardiovascular research 2012;94(1):20-9.
2012: Olivia Hibbitt; C Owen; L Seymour; S Agkatsev; Keith M Channon; M Cioroch; Richard Wade-Martins
RNAi-mediated knockdown of HMG CoA reductase enhances gene expression from physiologically regulated low-density lipoprotein receptor therapeutic vectors in vivo.
Gene therapy 2012;19(4):463-7.
2012: David Adlam; Barbara Casadei; Stephanie J Cragg; E J F Danson; Joseph P de Bono; Gillian Douglas; Neil Herring; Katie A Jennings; Dan Li; Cheih-Ju Lu; David J Paterson; Amy Tatham; Keith M Channon
Regulation of β-adrenergic control of heart rate by GTP-cyclohydrolase 1 (GCH1) and tetrahydrobiopterin.
Cardiovascular research 2012;93(4):694-701.
2012: Regent Lee; Keith M Channon; Charalambos Antoniades
Therapeutic strategies targeting endothelial function in humans: clinical implications.
Current vascular pharmacology 2012;10(1):77-93.
2011: Charalambos Antoniades; Alexis Antonopoulos; Constantinos Bakogiannis; Jennifer Bendall; Ruha Cerrato; Colin Cunnington; Michael Demosthenous; Ashley Hale; Fredrik Karpe; Paul Leeson; Marios Margaritis; Kyriakoula Marinou; Matt Neville; Christodoulos I Stefanadis; Dimitris Tousoulis; Marina Toutouza; Charalambos Vlachopoulos; Keith M Channon
Induction of vascular GTP-cyclohydrolase I and endogenous tetrahydrobiopterin synthesis protect against inflammation-induced endothelial dysfunction in human atherosclerosis.
Circulation 2011;124(17):1860-70.
2011: An L Moens; Charles A O'Neill; Tim S Schmidt; Eiki Takimoto; Michael S Wolin; Nicholas J Alp; Keith M Channon; Elizabeth A Ketner; David A Kass
Bi-modal dose-dependent cardiac response to tetrahydrobiopterin in pressure-overload induced hypertrophy and heart failure.
Journal of molecular and cellular cardiology 2011;51(4):564-9.
2011: Mark Crabtree; Keith M Channon
Synthesis and recycling of tetrahydrobiopterin in endothelial function and vascular disease.
Nitric oxide : biology and chemistry / official journal of the Nitric Oxide Society 2011;25(2):81-8.
2011: Charalambos Antoniades; Alexios S Antonopoulos; Constantinos Bakogiannis; Jennifer Bendall; Barbara Casadei; Michael Demosthenous; Tomasz Guzik; Ashley Hale; Paul Leeson; Kyriakoula Marinou; Andreas Paschalis; Costas Psarros; Christodoulos I Stefanadis; Dimitris Tousoulis; Costas Triantafyllou; Mei-Hua Zhang; Keith M Channon
Rapid, direct effects of statin treatment on arterial redox state and nitric oxide bioavailability in human atherosclerosis via tetrahydrobiopterin-mediated endothelial nitric oxide synthase coupling.
Circulation 2011;124(3):335-45.
2011: David Adlam; Keith M Channon
Radial artery graft string sign due to lumen obliteration by neointima: insight from optical coherence tomography.
JACC. Cardiovascular interventions 2011;4(5):586-7.
2011: Erica Dall'Armellina; Nina Karia; Alistair C Lindsay; Theodoros D Karamitsos; Vanessa Ferreira; Matthew D Robson; Peter Kellman; Jane M Francis; Colin Forfar; Bernard D Prendergast; Adrian P Banning; Keith M Channon; Rajesh K Kharbanda; Stefan Neubauer; Robin P Choudhury
Dynamic changes of edema and late gadolinium enhancement after acute myocardial infarction and their relationship to functional recovery and salvage index.
Circulation. Cardiovascular imaging 2011;4(3):228-36.
2011: D C Hutchings; D Adlam; V Ferreira; Theodoros D Karamitsos; Keith M Channon
Takotsubo cardiomyopathy in association with endogenous and exogenous thyrotoxicosis.
QJM : monthly journal of the Association of Physicians 2011;104(5):433-5.
2011: David Adlam; David Hutchings; Keith M Channon
Optical coherence tomography-guided stenting of a large coronary aneurysm: images at implantation and at 6 months.
The Journal of invasive cardiology 2011;23(4):168-9.
2010: Colin Cunnington; Keith M Channon
Tetrahydrobiopterin: pleiotropic roles in cardiovascular pathophysiology.
Heart (British Cardiac Society) 2010;96(23):1872-7.
2010: Chris Lim; Adrian Banning; Keith M Channon
Optical coherence tomography in the diagnosis and treatment of spontaneous coronary artery dissection.
The Journal of invasive cardiology 2010;22(11):559-60.
2010: G A Figtree; Bruce G Robinson; Keith M Channon; Hugh Watkins
Polymorphism upstream of estrogen receptor alpha reverses negative regulation of transcription.
International journal of cardiology 2010;144(1):86-8.
2010: Charalambos Antoniades; Constantinos Bakogiannis; Dimitris Tousoulis; Svetlana Reilly; Mei-Hua Zhang; Andreas Paschalis; Alexios S Antonopoulos; Michael Demosthenous; Antigoni Miliou; Costas Psarros; Kyriakoula Marinou; Nikolaos Sfyras; George Economopoulos; Barbara Casadei; Keith M Channon; Christodoulos I Stefanadis
Preoperative atorvastatin treatment in CABG patients rapidly improves vein graft redox state by inhibition of Rac1 and NADPH-oxidase activity.
Circulation 2010;122(11 Suppl):S66-73.
2009: Clare E Jackson; Cheerag Shirodaria; Justin M S Lee; Jane M Francis; Robin P Choudhury; Keith M Channon; Alison Noble; Stefan Neubauer; Matthew D Robson
Reproducibility and accuracy of automated measurement for dynamic arterial lumen area by cardiovascular magnetic resonance.
The international journal of cardiovascular imaging 2009;25(8):797-808.
2009: Kazem Rahimi; Adrian P Banning; A S H Cheng; T J Pegg; Theodoros D Karamitsos; Keith M Channon; Sarah C Darby; David P Taggart; Stefan Neubauer; Joseph B Selvanayagam
Prognostic value of coronary revascularisation-related myocardial injury: a cardiac magnetic resonance imaging study.
Heart (British Cardiac Society) 2009;95(23):1937-43.
2009: Justin Lee; Matthew D Robson; Ly-Mee Yu; Cheerag Shirodaria; Colin Cunnington; Ilias Kylintireas; Janet E Digby; Thomas Bannister; Ashok Handa; Frank Wiesmann; Paul N Durrington; Keith M Channon; Stefan Neubauer; Robin P Choudhury
Effects of high-dose modified-release nicotinic acid on atherosclerosis and vascular function: a randomized, placebo-controlled, magnetic resonance imaging study.
Journal of the American College of Cardiology 2009;54(19):1787-94.
2009: An L Moens; Jordan S Leyton-Mange; Xiaolin Niu; Ronghua Yang; Oscar Horacio Cingolani; Elisabeth K Arkenbout; Hunter C Champion; Djahida Bedja; Kathleen L Gabrielson; Juan Chen; Yong Xia; Ashley B Hale; Keith M Channon; Marc K Halushka; NORMAN BARKER; Floris L Wuyts; Pawel M Kaminski; Michael S Wolin; David A Kass; Lili A Barouch
Adverse ventricular remodeling and exacerbated NOS uncoupling from pressure-overload in mice lacking the beta3-adrenoreceptor.
Journal of molecular and cellular cardiology 2009;47(5):576-85.
2009: Mark Crabtree; Amy L Tatham; Ashley B Hale; Nicholas J Alp; Keith M Channon
Critical role for tetrahydrobiopterin recycling by dihydrofolate reductase in regulation of endothelial nitric-oxide synthase coupling: relative importance of the de novo biopterin synthesis versus salvage pathways.
The Journal of biological chemistry 2009;284(41):28128-36.
2009: Charalambos Antoniades; Tim Van-Assche; Cheerag Shirodaria; Jonathan Diesch; Alexios S Antonopoulos; Justin Lee; Colin Cunnington; Dimitris Tousoulis; Christodoulos I Stefanadis; Barbara Casadei; David P Taggart; Keith M Channon; Paul Leeson
Preoperative sCD40L levels predict risk of atrial fibrillation after off-pump coronary artery bypass graft surgery.
Circulation 2009;120(11 Suppl):S170-6.
2009: David Adlam; Rachael Ayers; Keith M Channon
Intimal dissection causing late thrombosis of a covered stent: optical coherence tomography appearances.
Circulation. Cardiovascular interventions 2009;2(4):359-60.
2009: Chee-Wan Lee; Dan Li; Keith M Channon; David J Paterson
L-arginine supplementation reduces cardiac noradrenergic neurotransmission in spontaneously hypertensive rats.
Journal of molecular and cellular cardiology 2009;47(1):149-55.
2009: Amy L Tatham; Mark Crabtree; Nicholas Warrick; Shijie Cai; Nicholas J Alp; Keith M Channon
GTP cyclohydrolase I expression, protein, and activity determine intracellular tetrahydrobiopterin levels, independent of GTP cyclohydrolase feedback regulatory protein expression.
The Journal of biological chemistry 2009;284(20):13660-8.
2009: Charalambos Antoniades; Cheerag Shirodaria; Paul Leeson; Otto A Baarholm; Tim Van-Assche; Colin Cunnington; Ravi Pillai; Chandana Ratnatunga; Dimitris Tousoulis; Christodoulos I Stefanadis; Helga Refsum; Keith M Channon
MTHFR 677 C>T Polymorphism reveals functional importance for 5-methyltetrahydrofolate, not homocysteine, in regulation of vascular redox state and endothelial function in human atherosclerosis.
Circulation 2009;119(18):2507-15.
2009: Charalambos Antoniades; Cheerag Shirodaria; Paul Leeson; Alexios Antonopoulos; Nicholas Warrick; Tim Van-Assche; Colin Cunnington; Dimitris Tousoulis; Ravi Pillai; Chandana Ratnatunga; Christodoulos I Stefanadis; Keith M Channon
Association of plasma asymmetrical dimethylarginine (ADMA) with elevated vascular superoxide production and endothelial nitric oxide synthase uncoupling: implications for endothelial function in human atherosclerosis.
European heart journal 2009;30(9):1142-50.
2009: Charalambos Antoniades; Shafi Mussa; Cheerag Shirodaria; Justin Lee; Jonathan Diesch; David P Taggart; Keith M Channon; Paul Leeson
Relation of preoperative radial artery flow-mediated dilatation to nitric oxide bioavailability in radial artery grafts used in off-pump coronary artery bypass grafting.
The American journal of cardiology 2009;103(2):216-20.
2009: Mark Crabtree; Amy L Tatham; Yasir Al-Wakeel; Nicholas Warrick; Ashley B Hale; Shijie Cai; Keith M Channon; Nicholas J Alp
Quantitative regulation of intracellular endothelial nitric-oxide synthase (eNOS) coupling by both tetrahydrobiopterin-eNOS stoichiometry and biopterin redox status: insights from cells with tet-regulated GTP cyclohydrolase I expression.
The Journal of biological chemistry 2009;284(2):1136-44.
2009: Charalambos Antoniades; Alexios S Antonopoulos; Jennifer K Bendall; Keith M Channon
Targeting redox signaling in the vascular wall: from basic science to clinical practice.
Current pharmaceutical design 2009;15(3):329-42.
2009: Christina A Bursill; E McNeill; L Wang; O C Hibbitt; Richard Wade-Martins; David J Paterson; David Greaves; Keith M Channon
Lentiviral gene transfer to reduce atherosclerosis progression by long-term CC-chemokine inhibition.
Gene therapy 2009;16(1):93-102.
2008: Ryan G Schrale; William J Van Gaal; Keith M Channon; J Colin Forfar; Oliver J Ormerod; Adrian P Banning
Long-term outcomes of percutaneous coronary intervention for unprotected left main coronary artery disease.
International journal of cardiology 2008;130(2):185-9.
2008: Ziad A Ali; Christina A Bursill; Gillian Douglas; Eileen McNeill; Marianna Papaspyridonos; Amy L Tatham; Jennifer K Bendall; Asim M Akhtar; Nicholas J Alp; David Greaves; Keith M Channon
CCR2-mediated antiinflammatory effects of endothelial tetrahydrobiopterin inhibit vascular injury-induced accelerated atherosclerosis.
Circulation 2008;118(14 Suppl):S71-7.
2008: Alexandra Doehring; Charalambos Antoniades; Keith M Channon; Irmgard Tegeder; Jörn Lötsch
Clinical genetics of functionally mild non-coding GTP cyclohydrolase 1 (GCH1) polymorphisms modulating pain and cardiovascular risk.
Mutation research 2008;659(3):195-201.
2008: Gemma A Figtree; Stuart M Grieve; Bridget Speller; Mary-Jane Geiger; Bruce G Robinson; Keith M Channon; Jiannis Ragoussis; Peter Collins; Hugh Watkins
A commonly occurring polymorphism upstream of the estrogen receptor alpha alters transcription and is associated with increased HDL.
Atherosclerosis 2008;199(2):354-61.
2008: Charalambos Antoniades; Cheerag Shirodaria; Tim Van Assche; Colin Cunnington; Irmgard Tegeder; Jörn Lötsch; Tomasz Guzik; Paul Leeson; Jonathan Diesch; Dimitris Tousoulis; Christodoulos I Stefanadis; Michael Costigan; Clifford J Woolf; Nicholas J Alp; Keith M Channon
GCH1 haplotype determines vascular and plasma biopterin availability in coronary artery disease effects on vascular superoxide production and endothelial function.
Journal of the American College of Cardiology 2008;52(2):158-65.
2008: An L Moens; Eiki Takimoto; Carlo G Tocchetti; Khalid Chakir; Djahida Bedja; Gianfranco Cormaci; Elizabeth A Ketner; Maulik Majmudar; Kathleen L Gabrielson; Marc K Halushka; James B Mitchell; Shyam Biswal; Keith M Channon; Michael S Wolin; Nicholas J Alp; Nazareno Paolocci; Hunter C Champion; David A Kass
Reversal of cardiac hypertrophy and fibrosis from pressure overload by tetrahydrobiopterin: efficacy of recoupling nitric oxide synthase as a therapeutic strategy.
Circulation 2008;117(20):2626-36.
2008: Tammie Bishop; Denis Gallagher; Alberto Pascual; Craig A Lygate; Joseph P de Bono; Lynn G Nicholls; Patricia Ortega-Saenz; Henrik Oster; Bhathiya Wijeyekoon; Andrew I Sutherland; Alexandra Grosfeld; Julian Aragones; Martin Schneider; Katie van Geyte; Dania Teixeira; Antonio Diez-juan; Jose Lopez-Barneo; Keith M Channon; Patrick H Maxwell; Christopher W Pugh; Alun M Davies; Peter Carmeliet; Peter J Ratcliffe
Abnormal sympathoadrenal development and systemic hypotension in PHD3-/- mice.
Molecular and cellular biology 2008;28(10):3386-400.
2008: Justin Lee; Frank Wiesmann; Cheerag Shirodaria; Paul Leeson; Steffen E Petersen; Jane M Francis; Clare E Jackson; Matthew D Robson; Stefan Neubauer; Keith M Channon; Robin P Choudhury
Early changes in arterial structure and function following statin initiation: quantification by magnetic resonance imaging.
Atherosclerosis 2008;197(2):951-8.
2008: Matthias Groszer; David A Keays; Robert M J Deacon; Joseph P de Bono; Shweta Prasad-Mulcare; Simone Gaub; Muriel G Baum; Catherine A French; Jérôme Nicod; Julie A Coventry; Wolfgang Enard; Martin Fray; Steve D M Brown; Patrick M Nolan; Svante Pääbo; Keith M Channon; Rui M Costa; Jens Eilers; Günter Ehret; J Nicholas P Rawlins; Simon E Fisher
Impaired synaptic plasticity and motor learning in mice with a point mutation implicated in human speech deficits.
Current biology : CB 2008;18(5):354-62.
2008: Marianna Papaspyridonos; Eileen McNeill; Joe P de Bono; Alberto Smith; Kevin G Burnand; Keith M Channon; David Greaves
Galectin-3 is an amplifier of inflammation in atherosclerotic plaque progression through macrophage activation and monocyte chemoattraction.
Arteriosclerosis, thrombosis, and vascular biology 2008;28(3):433-40.
2008: Yan-Hua Du; Yong-Yuan Guan; Nicholas J Alp; Keith M Channon; Alex F Chen
Endothelium-specific GTP cyclohydrolase I overexpression attenuates blood pressure progression in salt-sensitive low-renin hypertension.
Circulation 2008;117(8):1045-54.
2008: Monique R Robinson; Michaela Scheuermann-Freestone; Paul Leeson; Keith M Channon; Kieran Clarke; Stefan Neubauer; Frank Wiesmann
Uncomplicated obesity is associated with abnormal aortic function assessed by cardiovascular magnetic resonance.
Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance 2008;10():10.
2008: Young M Kim; Hassan Kattach; Chandana Ratnatunga; Ravi Pillai; Keith M Channon; Barbara Casadei
Association of atrial nicotinamide adenine dinucleotide phosphate oxidase activity with the development of atrial fibrillation after cardiac surgery.
Journal of the American College of Cardiology 2008;51(1):68-74.
2008: Martina A. McAteer; Jürgen E Schneider; Ziad A Ali; Nicholas Warrick; Christina A Bursill; Constantin von zur Muhlen; David Greaves; Stefan Neubauer; Keith M Channon; Robin P Choudhury
Magnetic resonance imaging of endothelial adhesion molecules in mouse atherosclerosis using dual-targeted microparticles of iron oxide.
Arteriosclerosis, thrombosis, and vascular biology 2008;28(1):77-83.
2007: Charalambos Antoniades; Cheerag Shirodaria; Mark Crabtree; Ruth Rinze; Nicholas J Alp; Colin Cunnington; Jonathan Diesch; Dimitris Tousoulis; Christodoulos I Stefanadis; Paul Leeson; Chandana Ratnatunga; Ravi Pillai; Keith M Channon
Altered plasma versus vascular biopterins in human atherosclerosis reveal relationships between endothelial nitric oxide synthase coupling, endothelial function, and inflammation.
Circulation 2007;116(24):2851-9.
2007: Francis A Ponnuthurai; William J Van Gaal; Keith M Channon
Focal in-stent restenosis and in-stent thrombosis within the same bare-metal stent 5 years after deployment in a saphenous vein graft.
The Journal of invasive cardiology 2007;19(12):E369-71.
2007: Song-Jie Liao; Li Lin; Jin-sheng Zeng; Ru-xun Huang; Keith M Channon; Alex F Chen
Endothelium-targeted transgenic GTP-cyclohydrolase I overexpression inhibits neointima formation in mouse carotid artery.
Clinical and experimental pharmacology & physiology 2007;34(12):1260-6.
2007: Joseph P De Bono; Keith M Channon
Endothelial cell tetrahydrobiopterin: going with the flow.
Circulation research 2007;101(8):752-4.
2007: Ravinay Bhindi; Shahzad M Munir; Keith M Channon
Images in cardiovascular medicine. Optical coherence tomography in the setting of an acute anterior myocardial infarction.
Circulation 2007;116(14):e366-7.
2007: Martina A. McAteer; Nicola R Sibson; Constantin von Zur Muhlen; Jürgen E Schneider; Andrew S Lowe; Nicholas Warrick; Keith M Channon; Daniel Anthony; Robin P Choudhury
In vivo magnetic resonance imaging of acute brain inflammation using microparticles of iron oxide.
Nature medicine 2007;13(10):1253-8.
2007: Joseph B Selvanayagam; Adrian S H Cheng; Michael Jerosch-Herold; Kazem Rahimi; Italo Porto; William J Van Gaal; Keith M Channon; Stefan Neubauer; Adrian P Banning
Effect of distal embolization on myocardial perfusion reserve after percutaneous coronary intervention: a quantitative magnetic resonance perfusion study.
Circulation 2007;116(13):1458-64.
2007: Bikram P Choudhary; Charalambos Antoniades; Alison F Brading; Antony Galione; Keith M Channon; David P Taggart
Diabetes mellitus as a predictor for radial artery vasoreactivity in patients undergoing coronary artery bypass grafting.
Journal of the American College of Cardiology 2007;50(11):1047-53.
2007: Charalambos Antoniades; Cheerag Shirodaria; Christodoulos I Stefanadis; Keith M Channon
Homocysteine lowering: any use in atherosclerosis?
Hellenic journal of cardiology : HJC = Hellēnikē kardiologikē epitheōrēsē 2007;48(5):249-51.
2007: Stephen Westaby; Keith M Channon; Adrian Banning
To stent or not to stent?: A sterile debate.
BMJ (Clinical research ed.) 2007;335(7611):111.
2007: Ryan G Schrale; Keith M Channon; Oliver J Ormerod
IVUS-guided evaluation and percutaneous intervention in an anomalous left main coronary artery.
The Journal of invasive cardiology 2007;19(7):E195-8.
2007: Tomofumi Takaya; Ken-ichi Hirata; Tomoya Yamashita; Masakazu Shinohara; Naoto Sasaki; Nobutaka Inoue; Toyotaka Yada; Masami Goto; Akiko Fukatsu; Toshio Hayashi; Nicholas J Alp; Keith M Channon; Mitsuhiro Yokoyama; Seinosuke Kawashima
A specific role for eNOS-derived reactive oxygen species in atherosclerosis progression.
Arteriosclerosis, thrombosis, and vascular biology 2007;27(7):1632-7.
2007: Olivia C Hibbitt; Richard P Harbottle; Simon Waddington; Christine A Bursill; Charles Coutelle; Keith M Channon; Richard Wade-Martins
Delivery and long-term expression of a 135 kb LDLR genomic DNA locus in vivo by hydrodynamic tail vein injection.
The journal of gene medicine 2007;9(6):488-97.
2007: Cheerag Shirodaria; Charalambos Antoniades; Justin Lee; Clare E Jackson; Matthew D Robson; Jane M Francis; Stuart J Moat; Chandana Ratnatunga; Ravi Pillai; Helga Refsum; Stefan Neubauer; Keith M Channon
Global improvement of vascular function and redox state with low-dose folic acid: implications for folate therapy in patients with coronary artery disease.
Circulation 2007;115(17):2262-70.
2007: Jennifer K Bendall; Ruth Rinze; David Adlam; Amy L Tatham; Joseph P de Bono; Natalie Wilson; Emanuela Volpi; Keith M Channon
Endothelial Nox2 overexpression potentiates vascular oxidative stress and hemodynamic response to angiotensin II: studies in endothelial-targeted Nox2 transgenic mice.
Circulation research 2007;100(7):1016-25.
2007: Ziad A Ali; Nicholas J Alp; Henry Lupton; Nadine Arnold; Thomas Bannister; Yanhua Hu; Shafi Mussa; Mark Wheatcroft; David Greaves; Julian Gunn; Keith M Channon
Increased in-stent stenosis in ApoE knockout mice: insights from a novel mouse model of balloon angioplasty and stenting.
Arteriosclerosis, thrombosis, and vascular biology 2007;27(4):833-40.
2007: Sanju Mathew; Keith M Channon; Nicholas J Alp
'Full-house' rheumatic heart disease.
International journal of cardiology 2007;116(2):e55-6.
2007: Justin Lee; Cheerag Shirodaria; Clare E Jackson; Matthew D Robson; Charalambos Antoniades; Jane M Francis; Frank Wiesmann; Keith M Channon; Stefan Neubauer; Robin P Choudhury
Multi-modal magnetic resonance imaging quantifies atherosclerosis and vascular dysfunction in patients with type 2 diabetes mellitus.
Diabetes & vascular disease research : official journal of the International Society of Diabetes and Vascular Disease 2007;4(1):44-8.
2007: William J Van Gaal; Robin P Choudhury; Italo Porto; Keith M Channon; Adrian Banning; Vladimir Dzavik; Rachael Ramsamujh; Sanh Bui; Daniel J Blackman
Prediction of distal embolization during percutaneous coronary intervention in saphenous vein grafts.
The American journal of cardiology 2007;99(5):603-6.
2007: Daniel A Heaton; Dan Li; Susanna C Almond; Tom Dawson; Lijun Wang; Keith M Channon; David J Paterson
Gene transfer of neuronal nitric oxide synthase into intracardiac Ganglia reverses vagal impairment in hypertensive rats.
Hypertension 2007;49(2):380-8.
2007: Joseph P de Bono; Nicholas Warrick; Jennifer K Bendall; Keith M Channon; Nicholas J Alp
Radiochemical HPLC detection of arginine metabolism: measurement of nitric oxide synthesis and arginase activity in vascular tissue.
Nitric oxide : biology and chemistry / official journal of the Nitric Oxide Society 2007;16(1):1-9.
2007: Ryan G Schrale; Keith M Channon; Oliver J Ormerod
Anomalous circumflex artery: intravascular ultrasound imaging of dynamic compression and "two wire-two vessel" percutaneous intervention.
International journal of cardiology 2007;115(1):e41-3.
2007: David Adlam; Jennifer K Bendall; Joseph P de Bono; Nicholas J Alp; Jeffrey P Khoo; Taija Nicoli; Mitsuhiro Yokoyama; Seinosuke Kawashima; Keith M Channon
Relationships between nitric oxide-mediated endothelial function, eNOS coupling and blood pressure revealed by eNOS-GTP cyclohydrolase 1 double transgenic mice.
Experimental physiology 2007;92(1):119-26.
2006: Nick E J West; Charles J McKenna; Oliver J Ormerod; J Colin Forfar; Adrian P Banning; Keith M Channon
Percutaneous coronary intervention with stent deployment in anomalously-arising left circumflex coronary arteries.
Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions 2006;68(6):882-90.
2006: Christina A Bursill; Jenna L Cash; Keith M Channon; David Greaves
Membrane-bound CC chemokine inhibitor 35K provides localized inhibition of CC chemokine activity in vitro and in vivo.
Journal of immunology (Baltimore, Md. : 1950) 2006;177(8):5567-73.
2006: Qingzhong Xiao; Lingfang Zeng; Zhongyi Zhang; Andriana Margariti; Ziad A Ali; Keith M Channon; Qingbo Xu; Yanhua Hu
Sca-1+ progenitors derived from embryonic stem cells differentiate into endothelial cells capable of vascular repair after arterial injury.
Arteriosclerosis, thrombosis, and vascular biology 2006;26(10):2244-51.
2006: Charalambos Antoniades; Cheerag Shirodaria; Nicholas Warrick; Shijie Cai; Joseph P de Bono; Justin Lee; Paul Leeson; Stefan Neubauer; Chandana Ratnatunga; Ravi Pillai; Helga Refsum; Keith M Channon
5-methyltetrahydrofolate rapidly improves endothelial function and decreases superoxide production in human vessels: effects on vascular tetrahydrobiopterin availability and endothelial nitric oxide synthase coupling.
Circulation 2006;114(11):1193-201.
2006: Steffen E Petersen; Frank Wiesmann; Lucy E Hudsmith; Matthew D Robson; Jane M Francis; Joseph B Selvanayagam; Stefan Neubauer; Keith M Channon
Functional and structural vascular remodeling in elite rowers assessed by cardiovascular magnetic resonance.
Journal of the American College of Cardiology 2006;48(4):790-7.
2006: Italo Porto; Joseph B Selvanayagam; William J Van Gaal; Francesco Prati; Adrian Cheng; Keith M Channon; Stefan Neubauer; Adrian P Banning
Plaque volume and occurrence and location of periprocedural myocardial necrosis after percutaneous coronary intervention: insights from delayed-enhancement magnetic resonance imaging, thrombolysis in myocardial infarction myocardial perfusion grade analysis, and intravascular ultrasound.
Circulation 2006;114(7):662-9.
2006: Sarah George; Keith M Channon; Andrew H Baker
Gene therapy and coronary artery bypass grafting: current perspectives.
Current opinion in molecular therapeutics 2006;8(4):288-94.
2006: Italo Porto; Robin P Choudhury; P Pillay; Francesco Burzotta; Carlo Trani; Giampaolo Niccoli; Daniel J Blackman; Keith M Channon; Adrian P Banning
Filter no reflow during percutaneous coronary interventions using the Filterwire distal protection device.
International journal of cardiology 2006;109(1):53-8.
2006: Per Lav Madsen; Michaela Scheuermann-Freestone; Stefan Neubauer; Keith M Channon; Kieran Clarke
Haemoglobin and flow-mediated vasodilation.
Clinical science (London, England : 1979) 2006;110(4):467-73.
2006: Joseph P de Bono; David Adlam; D J Paterson; Keith M Channon
Novel quantitative phenotypes of exercise training in mouse models.
American journal of physiology. Regulatory, integrative and comparative physiology 2006;290(4):R926-34.
2006: Tomasz Guzik; Jerzy Sadowski; Bartlomiej Guzik; Andrzej Jopek; Boguslaw Kapelak; Piotr Przybylowski; Karol Wierzbicki; Ryszard Korbut; David G Harrison; Keith M Channon
Coronary artery superoxide production and nox isoform expression in human coronary artery disease.
Arteriosclerosis, thrombosis, and vascular biology 2006;26(2):333-9.
2006: C Paul Leeson; M Robinson; Jane M Francis; Matthew D Robson; Keith M Channon; Stefan Neubauer; Frank Wiesmann
Cardiovascular magnetic resonance imaging for non-invasive assessment of vascular function: validation against ultrasound.
Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance 2006;8(2):381-7.
2006: David P Taggart; Belinda Lees; Alastair M Gray; Douglas Altman; Marcus Flather; Keith M Channon
Protocol for the Arterial Revascularisation Trial (ART). A randomised trial to compare survival following bilateral versus single internal mammary grafting in coronary revascularisation [ISRCTN46552265].
Trials 2006;7():7.
2005: Joseph B Selvanayagam; Michael Jerosch-Herold; Italo Porto; David Sheridan; Adrian S H Cheng; Steffen E Petersen; Nick Searle; Keith M Channon; Adrian P Banning; Stefan Neubauer
Resting myocardial blood flow is impaired in hibernating myocardium: a magnetic resonance study of quantitative perfusion assessment.
Circulation 2005;112(21):3289-96.
2005: Daniel J Blackman; Robin P Choudhury; Adrian P Banning; Keith M Channon
Failure of the Symbiot PTFE-covered stent to reduce distal embolization during percutaneous coronary intervention in saphenous vein grafts.
The Journal of invasive cardiology 2005;17(11):609-12.
2005: Jennifer K Bendall; Nicholas J Alp; Nicholas Warrick; Shijie Cai; David Adlam; Kirk Rockett; Mitsuhiro Yokoyama; Seinosuke Kawashima; Keith M Channon
Stoichiometric relationships between endothelial tetrahydrobiopterin, endothelial NO synthase (eNOS) activity, and eNOS coupling in vivo: insights from transgenic mice with endothelial-targeted GTP cyclohydrolase 1 and eNOS overexpression.
Circulation research 2005;97(9):864-71.
2005: Robin P Choudhury; Daniel J Blackman; Keith M Channon
Images in cardiology: Distal embolisation in percutaneous saphenous vein graft intervention despite use of a polymer covered stent.
Heart (British Cardiac Society) 2005;91(10):1259.
2005: Young M Kim; Tomasz Guzik; Yin Hua Zhang; Mei Hua Zhang; Hassan Kattach; Chandana Ratnatunga; Ravi Pillai; Keith M Channon; Barbara Casadei
A myocardial Nox2 containing NAD(P)H oxidase contributes to oxidative stress in human atrial fibrillation.
Circulation research 2005;97(7):629-36.
2005: Shijie Cai; Jeffrey P Khoo; Shafi Mussa; Nicholas J Alp; Keith M Channon
Endothelial nitric oxide synthase dysfunction in diabetic mice: importance of tetrahydrobiopterin in eNOS dimerisation.
Diabetologia 2005;48(9):1933-40.
2005: Ziad A Ali; Christina A Bursill; Yanhua Hu; Robin P Choudhury; Qingbo Xu; David Greaves; Keith M Channon
Gene transfer of a broad spectrum CC-chemokine inhibitor reduces vein graft atherosclerosis in apolipoprotein E-knockout mice.
Circulation 2005;112(9 Suppl):I235-41.
2005: Yu-Long Li; Yi-Fan Li; Dongmei Liu; Kurtis G Cornish; Kaushik P Patel; Irving H Zucker; Keith M Channon; Harold D Schultz
Gene transfer of neuronal nitric oxide synthase to carotid body reverses enhanced chemoreceptor function in heart failure rabbits.
Circulation research 2005;97(3):260-7.
2005: William H Miller; M Julia Brosnan; Delyth Graham; Campbell G Nicol; Ian Morecroft; Keith M Channon; Sergei M Danilov; Paul N Reynolds; Andrew H Baker; Anna F Dominiczak
Targeting endothelial cells with adenovirus expressing nitric oxide synthase prevents elevation of blood pressure in stroke-prone spontaneously hypertensive rats.
Molecular therapy : the journal of the American Society of Gene Therapy 2005;12(2):321-7.
2005: Daniel A Heaton; Simon Golding; Chris P Bradley; Tom Dawson; S Cai; Keith M Channon; David J Paterson
Targeted nNOS gene transfer into the cardiac vagus rapidly increases parasympathetic function in the pig.
Journal of molecular and cellular cardiology 2005;39(1):159-64.
2005: Tomasz Guzik; Rafal Olszanecki; Jerzy Sadowski; Boguslaw Kapelak; P Rudziński; Andrzej Jopek; A Kawczynska; Natalia Ryszawa; J Loster; Jacek Jawien; Marta Czesnikiewicz-Guzik; Keith M Channon; Ryszard Korbut
Superoxide dismutase activity and expression in human venous and arterial bypass graft vessels.
Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 2005;56(2):313-23.
2005: Jeffrey P Khoo; Lan Zhao; Nicholas J Alp; Jennifer K Bendall; Taija Nicoli; Kirk Rockett; Martin R Wilkins; Keith M Channon
Pivotal role for endothelial tetrahydrobiopterin in pulmonary hypertension.
Circulation 2005;111(16):2126-33.
2005: Joseph B Selvanayagam; Italo Porto; Keith M Channon; Steffen E Petersen; Jane M Francis; Stefan Neubauer; Adrian P Banning
Troponin elevation after percutaneous coronary intervention directly represents the extent of irreversible myocardial injury: insights from cardiovascular magnetic resonance imaging.
Circulation 2005;111(8):1027-32.
2005: Shijie Cai; Jeffrey P Khoo; Keith M Channon
Augmented BH4 by gene transfer restores nitric oxide synthase function in hyperglycemic human endothelial cells.
Cardiovascular research 2005;65(4):823-31.
2005: Tomasz Guzik; Keith M Channon
Measurement of vascular reactive oxygen species production by chemiluminescence.
Methods in molecular medicine 2005;108():73-89.
2005: Yi-Fan Li; Yu Wang; Keith M Channon; Harold D Schultz; Irving H Zucker; Kaushik P Patel
Manipulation of neuronal nitric oxide synthase within the paraventricular nucleus using adenovirus and antisense technology.
Methods in molecular medicine 2005;112():59-79.
2004: Denise M McDonald; Nicholas J Alp; Keith M Channon
Functional comparison of the endothelial nitric oxide synthase Glu298Asp polymorphic variants in human endothelial cells.
Pharmacogenetics 2004;14(12):831-9.
2004: Jürgen E Schneider; Martina A. McAteer; Damian J Tyler; Kieran Clarke; Keith M Channon; Robin P Choudhury; Stefan Neubauer
High-resolution, multicontrast three-dimensional-MRI characterizes atherosclerotic plaque composition in ApoE-/- mice ex vivo.
Journal of magnetic resonance imaging : JMRI 2004;20(6):981-9.
2004: Italo Porto; Daniel J Blackman; D Nicolson; Giampaolo Niccoli; F Z Kahn; Oliver J Ormerod; C Forfar; Keith M Channon; Adrian P Banning
What is the incidence of myocardial necrosis in elective patients discharged on the same day following percutaneous coronary intervention?
Heart (British Cardiac Society) 2004;90(12):1489-90.
2004: Cynthia J Meininger; Shijie Cai; Janet L Parker; Keith M Channon; Katherine A Kelly; Elizabeth J Becker; M Kathy Wood; Laura A Wade; Guoyao Wu
GTP cyclohydrolase I gene transfer reverses tetrahydrobiopterin deficiency and increases nitric oxide synthesis in endothelial cells and isolated vessels from diabetic rats.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2004;18(15):1900-2.
2004: Martina A. McAteer; Jürgen E Schneider; Kieran Clarke; Stefan Neubauer; Keith M Channon; Robin P Choudhury
Quantification and 3D reconstruction of atherosclerotic plaque components in apolipoprotein E knockout mice using ex vivo high-resolution MRI.
Arteriosclerosis, thrombosis, and vascular biology 2004;24(12):2384-90.
2004: Frank Wiesmann; Steffen E Petersen; Paul M Leeson; Jane M Francis; Matthew D Robson; Qian Wang; Robin P Choudhury; Keith M Channon; Stefan Neubauer
Global impairment of brachial, carotid, and aortic vascular function in young smokers: direct quantification by high-resolution magnetic resonance imaging.
Journal of the American College of Cardiology 2004;44(10):2056-64.
2004: Keith M Channon
Tetrahydrobiopterin: regulator of endothelial nitric oxide synthase in vascular disease.
Trends in cardiovascular medicine 2004;14(8):323-7.
2004: Shafi Mussa; Tash Prior; Nicholas J Alp; Kathryn Wood; Keith M Channon; David P Taggart
Duration of action of antispasmodic agents: novel use of a mouse model as an in vivo pharmacological assay.
European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery 2004;26(5):988-94.
2004: Christina A Bursill; Robin P Choudhury; Ziad A Ali; David Greaves; Keith M Channon
Broad-spectrum CC-chemokine blockade by gene transfer inhibits macrophage recruitment and atherosclerotic plaque formation in apolipoprotein E-knockout mice.
Circulation 2004;110(16):2460-6.
2004: Marco Cattaruzza; Tomasz Guzik; Wojciech Słodowski; Ayşegül Pelvan; Jürgen Becker; Martin Halle; Arnd B Buchwald; Keith M Channon; Markus Hecker
Shear stress insensitivity of endothelial nitric oxide synthase expression as a genetic risk factor for coronary heart disease.
Circulation research 2004;95(8):841-7.
2004: Daniel J Blackman; Italo Porto; Cheerag Shirodaria; Keith M Channon; Adrian P Banning
Usefulness of high-pressure post-dilatation to optimize deployment of drug-eluting stents for the treatment of diffuse in-stent coronary restenosis.
The American journal of cardiology 2004;94(7):922-5.
2004: Tomasz Guzik; Jerzy Sadowski; Boguslaw Kapelak; Andrzej Jopek; Pawel Rudzinski; Ravi Pillai; Ryszard Korbut; Keith M Channon
Systemic regulation of vascular NAD(P)H oxidase activity and nox isoform expression in human arteries and veins.
Arteriosclerosis, thrombosis, and vascular biology 2004;24(9):1614-20.
2004: Andreas Schäfer; Nicholas J Alp; Shije Cai; Craig A Lygate; Stefan Neubauer; Martin Eigenthaler; Johann Bauersachs; Keith M Channon
Reduced vascular NO bioavailability in diabetes increases platelet activation in vivo.
Arteriosclerosis, thrombosis, and vascular biology 2004;24(9):1720-6.
2004: E J F Danson; K S Mankia; Simon Golding; Tom Dawson; L Everatt; S Cai; Keith M Channon; David J Paterson
Impaired regulation of neuronal nitric oxide synthase and heart rate during exercise in mice lacking one nNOS allele.
The Journal of physiology 2004;558(Pt 3):963-74.
2004: Jeffrey P Khoo; Taija Nicoli; Nicholas J Alp; Janice Fullerton; Jonathan Flint; Keith M Channon
Congenic mapping and genotyping of the tetrahydrobiopterin-deficient hph-1 mouse.
Molecular genetics and metabolism 2004;82(3):251-4.
2004: Keith M Channon; Hugh Watkins
Coronary artery disease genetics: bigger is better.
European heart journal 2004;25(11):900-1.
2004: Jeffrey P Khoo; Nicholas J Alp; Jennifer K Bendall; Seinosuke Kawashima; Mitsuhiro Yokoyama; Yin-Hua Zhang; Barbara Casadei; Keith M Channon
EPR quantification of vascular nitric oxide production in genetically modified mouse models.
Nitric oxide : biology and chemistry / official journal of the Nitric Oxide Society 2004;10(3):156-61.
2004: Andreas Schäfer; Frank Wiesmann; Stefan Neubauer; Martin Eigenthaler; Johann Bauersachs; Keith M Channon
Rapid regulation of platelet activation in vivo by nitric oxide.
Circulation 2004;109(15):1819-22.
2004: Christina A Bursill; Keith M Channon; David Greaves
The role of chemokines in atherosclerosis: recent evidence from experimental models and population genetics.
Current opinion in lipidology 2004;15(2):145-9.
2004: Nicholas J Alp; Martina A. McAteer; Jeffrey P Khoo; Robin P Choudhury; Keith M Channon
Increased endothelial tetrahydrobiopterin synthesis by targeted transgenic GTP-cyclohydrolase I overexpression reduces endothelial dysfunction and atherosclerosis in ApoE-knockout mice.
Arteriosclerosis, thrombosis, and vascular biology 2004;24(3):445-50.
2004: Nicholas J Alp; Keith M Channon
Regulation of endothelial nitric oxide synthase by tetrahydrobiopterin in vascular disease.
Arteriosclerosis, thrombosis, and vascular biology 2004;24(3):413-20.
2004: Qian Wang; Matthew D Robson; Jane M Francis; Steffen E Petersen; Keith M Channon; Stefan Neubauer; Frank Wiesmann
Accuracy of quantitative MR vessel wall imaging applying a semi-automated gradient detection algorithm--a validation study.
Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance 2004;6(4):895-907.
2003: Shafi Mussa; Tomasz Guzik; Edward Black; Michelle Dipp; Keith M Channon; David P Taggart
Comparative efficacies and durations of action of phenoxybenzamine, verapamil/nitroglycerin solution, and papaverine as topical antispasmodics for radial artery coronary bypass grafting.
The Journal of thoracic and cardiovascular surgery 2003;126(6):1798-805.
2003: Frank Wiesmann; Matthew D Robson; Jane Francis; Steffen E Petersen; C Paul Leeson; Keith M Channon; Stefan Neubauer
Images in cardiovascular medicine. Visualization of the ruptured plaque by magnetic resonance imaging.
Circulation 2003;108(20):2542.
2003: Andrew D Lucas; Christina A Bursill; Tomasz Guzik; Jerzy Sadowski; Keith M Channon; David Greaves
Smooth muscle cells in human atherosclerotic plaques express the fractalkine receptor CX3CR1 and undergo chemotaxis to the CX3C chemokine fractalkine (CX3CL1).
Circulation 2003;108(20):2498-504.
2003: Yu Wang; Kaushik P Patel; Kurtis G Cornish; Keith M Channon; Irving H Zucker
nNOS gene transfer to RVLM improves baroreflex function in rats with chronic heart failure.
American journal of physiology. Heart and circulatory physiology 2003;285(4):H1660-7.
2003: Nicholas J Alp; Shafi Mussa; Jeffrey P Khoo; Shijie Cai; Tomasz Guzik; Andrew Jefferson; Nicky Goh; Kirk Rockett; Keith M Channon
Tetrahydrobiopterin-dependent preservation of nitric oxide-mediated endothelial function in diabetes by targeted transgenic GTP-cyclohydrolase I overexpression.
The Journal of clinical investigation 2003;112(5):725-35.
2003: Adrian P Banning; Oliver J Ormerod; Keith M Channon; Charles J McKenna; W Orr; BD Boulton; Y Bashir; J Colin Forfar
Same day discharge following elective percutaneous coronary intervention in patients with stable angina.
Heart (British Cardiac Society) 2003;89(6):665.
2003: Joseph B Selvanayagam; Steve Westaby; Keith M Channon; Jane Francis; Jonas Eichhõfer; Satoshi Saito; Stefan Neubauer
Images in cardiovascular medicine. Surgical left ventricular restoration: an extreme case.
Circulation 2003;107(10):e71.
2003: N Lever; John D Ferguson; Yaver Bashir; Keith M Channon
Prolonged temporary cardiac pacing using subcutaneous tunnelled active-fixation permanent pacing leads.
Heart (British Cardiac Society) 2003;89(2):209-10.
2003: Gemma A Figtree; Denise McDonald; Hugh Watkins; Keith M Channon
Truncated estrogen receptor alpha 46-kDa isoform in human endothelial cells: relationship to acute activation of nitric oxide synthase.
Circulation 2003;107(1):120-6.
2003: Christina A Bursill; Shijie Cai; Keith M Channon; David Greaves
Adenoviral-mediated delivery of a viral chemokine binding protein blocks CC-chemokine activity in vitro and in vivo.
Immunobiology 2003;207(3):187-96.
2003: Madhava J Naik; Yasir Abu-Omar; A Alvi; N Wright; A Henderson; Keith M Channon; J Colin Forfar; David P Taggart
Total arterial revascularisation as a primary strategy for coronary artery bypass grafting.
Postgraduate medical journal 2003;79(927):43-8.
2002: Ravi M Mohan; Daniel A Heaton; E J F Danson; S P R Krishnan; S Cai; Keith M Channon; David J Paterson
Neuronal nitric oxide synthase gene transfer promotes cardiac vagal gain of function.
Circulation research 2002;91(12):1089-91.
2002: Keith M Channon; Tomasz Guzik
Mechanisms of superoxide production in human blood vessels: relationship to endothelial dysfunction, clinical and genetic risk factors.
Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 2002;53(4 Pt 1):515-24.
2002: Keith M Channon
Oxidative stress and coronary plaque stability.
Arteriosclerosis, thrombosis, and vascular biology 2002;22(11):1751-2.
2002: David Greaves; Keith M Channon
Inflammation and immune responses in atherosclerosis.
Trends in immunology 2002;23(11):535-41.
2002: Kyriakos Anastasiadis; Keith M Channon; Chandana Ratnatunga
Traumatic innominate artery transection.
The Journal of cardiovascular surgery 2002;43(5):697-700.
2002: Nicholas J Alp; Nick E J West; Nadine Arnold; Julian Gunn; Adrian P Banning; Keith M Channon
Increased intimal hyperplasia in experimental vein graft stenting compared to arterial stenting: comparisons in a new rabbit model of stent injury.
Cardiovascular research 2002;56(1):164-72.
2002: Edward A Black; R Karen Campbell; Keith M Channon; Chandana Ratnatunga; Ravi Pillai
Minimally invasive vein harvesting significantly reduces pain and wound morbidity.
European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery 2002;22(3):381-6.
2002: Shijie Cai; Nicholas J Alp; Denise McDonald; Ian Smith; Jonathan Kay; Laura Canevari; Simon J R Heales; Keith M Channon
GTP cyclohydrolase I gene transfer augments intracellular tetrahydrobiopterin in human endothelial cells: effects on nitric oxide synthase activity, protein levels and dimerisation.
Cardiovascular research 2002;55(4):838-49.
2002: John D Ferguson; William P Orr; Charles J McKenna; Daniel J Blackman; Keith M Channon; J Colin Forfar; Oliver J Ormerod; Adrian P Banning
Percutaneous coronary intervention in octogenarians with refractory angina.
Heart (British Cardiac Society) 2002;88(1):85-6.
2002: Tomasz Guzik; Nick E J West; Ravi Pillai; David P Taggart; Keith M Channon
Nitric oxide modulates superoxide release and peroxynitrite formation in human blood vessels.
Hypertension 2002;39(6):1088-94.
2002: Tomasz Guzik; Shafi Mussa; Daniela Gastaldi; Jerzy Sadowski; Chandana Ratnatunga; Ravi Pillai; Keith M Channon
Mechanisms of increased vascular superoxide production in human diabetes mellitus: role of NAD(P)H oxidase and endothelial nitric oxide synthase.
Circulation 2002;105(14):1656-62.
2002: Yi-Fan Li; Shyamal K Roy; Keith M Channon; Irving H Zucker; Kaushik P Patel
Effect of in vivo gene transfer of nNOS in the PVN on renal nerve discharge in rats.
American journal of physiology. Heart and circulatory physiology 2002;282(2):H594-601.
2001: Nick E J West; H Qian; Tomasz Guzik; Edward Black; Shijie Cai; S E George; Keith M Channon
Nitric oxide synthase (nNOS) gene transfer modifies venous bypass graft remodeling: effects on vascular smooth muscle cell differentiation and superoxide production.
Circulation 2001;104(13):1526-32.
2001: Dicken D H Koo; Ken I Welsh; Nick E J West; Keith M Channon; A J Penington; JA Roake; Peter J Morris; Susan V Fuggle
Endothelial cell protection against ischemia/reperfusion injury by lecithinized superoxide dismutase.
Kidney international 2001;60(2):786-96.
2001: John D Ferguson; N Lever; Keith M Channon; Yaver Bashir
A simplified approach to temporary DDD pacing using a single lead, balloon-tipped catheter with overlapping biphasic impulse stimulation.
Pacing and clinical electrophysiology : PACE 2001;24(6):939-44.
2001: Edward A Black; Tomasz Guzik; Nick E J West; K Campbell; Ravi Pillai; Chandana Ratnatunga; Keith M Channon
Minimally invasive saphenous vein harvesting: effects on endothelial and smooth muscle function.
The Annals of thoracic surgery 2001;71(5):1503-7.
2001: Tomasz Guzik; Edward Black; Nick E J West; Denise McDonald; Chandana Ratnatunga; Ravi Pillai; Keith M Channon
Relationship between the G894T polymorphism (Glu298Asp variant) in endothelial nitric oxide synthase and nitric oxide-mediated endothelial function in human atherosclerosis.
American journal of medical genetics 2001;100(2):130-7.
2001: N West; Tomasz Guzik; Edward Black; Keith M Channon
Enhanced superoxide production in experimental venous bypass graft intimal hyperplasia: role of NAD(P)H oxidase.
Arteriosclerosis, thrombosis, and vascular biology 2001;21(2):189-94.
2000: Tomasz Guzik; Nick E J West; Edward Black; Denise McDonald; Chandana Ratnatunga; Ravi Pillai; Keith M Channon
Functional effect of the C242T polymorphism in the NAD(P)H oxidase p22phox gene on vascular superoxide production in atherosclerosis.
Circulation 2000;102(15):1744-7.
2000: Keith M Channon; H Qian; S E George
Nitric oxide synthase in atherosclerosis and vascular injury: insights from experimental gene therapy.
Arteriosclerosis, thrombosis, and vascular biology 2000;20(8):1873-81.
2000: John D Ferguson; N Lever; Yaver Bashir; Keith M Channon
Images in cardiology. Emergency DDD pacing using a single lead, balloon tip catheter.
Heart (British Cardiac Society) 2000;84(2):210.
2000: Tomasz Guzik; Nick E J West; Edward Black; Denise McDonald; Chandana Ratnatunga; Ravi Pillai; Keith M Channon
Vascular superoxide production by NAD(P)H oxidase: association with endothelial dysfunction and clinical risk factors.
Circulation research 2000;86(9):E85-90.
2000: Keith M Channon; B H Annex
Antithrombotic strategies in gene therapy.
Current cardiology reports 2000;2(1):34-8.
1999: Keith M Channon; A P Banning
Echocardiography in stroke and thromboembolism: transoesophageal imaging for all?
QJM : monthly journal of the Association of Physicians 1999;92(11):619-21.
1998: Keith M Channon; S Wadsworth; Yaver Bashir
Giant coronary artery aneurysm presenting as a mediastinal mass.
The American journal of cardiology 1998;82(10):1307-8, A11.
1998: Keith M Channon; Adrian P Banning; C H Davies; Yaver Bashir
Coronary artery aneurysm rupture mimicking dissection of the thoracic aorta.
International journal of cardiology 1998;65(1):115-7.
1997: C H Davies; Adrian P Banning; Keith M Channon; Oliver J Ormerod
Coronary stenting of unprotected left main stem stenoses in elderly patients unsuitable for coronary surgery.
International journal of cardiology 1997;62(1):13-8.
1997: Keith M Channon; M R Hargreaves; M Gardner; Oliver J Ormerod
Noninvasive beat-to-beat arterial blood pressure measurement during VVI and DDD pacing: relationship to symptomatic benefit from DDD pacing.
Pacing and clinical electrophysiology : PACE 1997;20(1 Pt 1):25-33.
1995: M R Hargreaves; Keith M Channon; T R Cripps; M Gardner; Oliver J Ormerod
Comparison of dual chamber and ventricular rate responsive pacing in patients over 75 with complete heart block.
British heart journal 1995;74(4):397-402.
1994: M Hargreaves; Keith M Channon
Mechanism of pacemaker induced cough.
British heart journal 1994;71(5):484-6.
1994: Keith M Channon; M R Hargreaves; T R Cripps; M Gardner; Oliver J Ormerod
DDD vs. VVI pacing in patients aged over 75 years with complete heart block: a double-blind crossover comparison.
The Quarterly journal of medicine 1994;87(4):245-51.
1993: M Hargreaves; Keith M Channon; O Ormerod
Emergency percutaneous transluminal coronary angioplasty (PTCA) for intractable ventricular arrhythmias associated with acute anterior myocardial infarction.
British heart journal 1993;70(5):485-6.
1992: Keith M Channon; T R Cripps; Oliver J Ormerod
Recommendations for pacing.
BMJ (Clinical research ed.) 1992;305(6866):1431; author reply 1432.