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Sandra Chaplan

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Mark S Tichenor; Michael Webb; Michelle L Wennerholm; Sandy J Wilson; Filip Woestenborghs; Dominiek Beerens; Marlies De Boeck; Sean M Brown; Sandra R Chaplan; Natalie Hawryluk; William M Jones; Mark J Karbarz; John M Keith; Lin Luo; Jeff Merit; James A Palmer; Joan M Pierce; Mark Seierstad; J Guy Breitenbucher
Heteroaryl urea inhibitors of fatty acid amide hydrolase: structure-mutagenicity relationships for arylamine metabolites.
Kelly J McClure; Alan D Wickenden; Nancy Wu; Brett Allison; J Guy Breitenbucher; Sandra R Chaplan; William A Eckert; Natalie Hawryluk; Michelle Hermann; Dong H Lee; Michael Maher; Cheryl A Grice
Discovery of a novel series of selective HCN1 blockers.
Michael P Maher; Jason C Rech; Michele Rizzolio; Brian Scott; Kia Sepassi; Nadia Swanson; Alan D Wickenden; Nyan-Tsz Wu; William A Eckert; Anne Fitzgerald; Jamie Freedman; Mena Kansagara; Alec D Lebsack; Dong H Li; Jing Liu; Yi Liu; Hong Ao; Anindya Bhattacharya; Bryan J Branstetter; J Guy Breitenbucher; Sandra R Chaplan
Characterization of 2-(2,6-dichloro-benzyl)-thiazolo[5,4-d]pyrimidin-7-yl]-(4-trifluoromethyl-phenyl)-amine (JNJ-39729209) as a novel TRPV1 antagonist.

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All Publications

2012: Mark S Tichenor; Michael Webb; Michelle L Wennerholm; Sandy J Wilson; Filip Woestenborghs; Dominiek Beerens; Marlies De Boeck; Sean M Brown; Sandra R Chaplan; Natalie Hawryluk; William M Jones; Mark J Karbarz; John M Keith; Lin Luo; Jeff Merit; James A Palmer; Joan M Pierce; Mark Seierstad; J Guy Breitenbucher
Heteroaryl urea inhibitors of fatty acid amide hydrolase: structure-mutagenicity relationships for arylamine metabolites.
Bioorganic & medicinal chemistry letters 2012;22(24):7357-62.
2011: Kelly J McClure; Alan D Wickenden; Nancy Wu; Brett Allison; J Guy Breitenbucher; Sandra R Chaplan; William A Eckert; Natalie Hawryluk; Michelle Hermann; Dong H Lee; Michael Maher; Cheryl A Grice
Discovery of a novel series of selective HCN1 blockers.
Bioorganic & medicinal chemistry letters 2011;21(18):5197-201.
2011: Michael P Maher; Jason C Rech; Michele Rizzolio; Brian Scott; Kia Sepassi; Nadia Swanson; Alan D Wickenden; Nyan-Tsz Wu; William A Eckert; Anne Fitzgerald; Jamie Freedman; Mena Kansagara; Alec D Lebsack; Dong H Li; Jing Liu; Yi Liu; Hong Ao; Anindya Bhattacharya; Bryan J Branstetter; J Guy Breitenbucher; Sandra R Chaplan
Characterization of 2-(2,6-dichloro-benzyl)-thiazolo[5,4-d]pyrimidin-7-yl]-(4-trifluoromethyl-phenyl)-amine (JNJ-39729209) as a novel TRPV1 antagonist.
European journal of pharmacology 2011;663(1-3):40-50.
2010: Natalie A Hawryluk; Jeffrey E Merit; Alec D Lebsack; Bryan J Branstetter; Michael D Hack; Nadia Swanson; Hong Ao; Michael P Maher; Anindya Bhattacharya; Qi Wang; Jamie M Freedman; Brian P Scott; Alan D Wickenden; Sandra R Chaplan; J Guy Breitenbucher
Discovery and synthesis of 6,7,8,9-tetrahydro-5H-pyrimido-[4,5-d]azepines as novel TRPV1 antagonists.
Bioorganic & medicinal chemistry letters 2010;20(23):7137-41.
2010: Alec D Lebsack; Jason C Rech; Bryan J Branstetter; Natalie A Hawryluk; Jeffrey E Merit; Brett Allison; Raymond Rynberg; Johnathan Buma; Michele Rizzolio; Nadia Swanson; Hong Ao; Michael P Maher; Michelle Herrmann; Jamie Freedman; Brian P Scott; Lin Luo; Anindya Bhattacharya; Qi Wang; Sandra R Chaplan; Alan D Wickenden; J Guy Breitenbucher
1,2-diamino-ethane-substituted-6,7,8,9-tetrahydro-5H-pyrimido[4,5-d]azepines as TRPV1 antagonists with improved properties.
Bioorganic & medicinal chemistry letters 2010;20(23):7142-6.
2009: Anindya Bhattacharya; Alan D Wickenden; Sandra R Chaplan
Sodium channel blockers for the treatment of neuropathic pain.
Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics 2009;6(4):663-78.
2009: Alan D Wickenden; Sandra R Chaplan
Once is not enough: improved efficacy following repeated dosing with a TRPV1 antagonist.
Pain 2009;142(1-2):5-6.
2009: Alan D Wickenden; M P Maher; Sandra R Chaplan
HCN pacemaker channels and pain: a drug discovery perspective.
Current pharmaceutical design 2009;15(18):2149-68.
2009: Michael P Maher; Nyan-Tsz Wu; Hong-Qing Guo; Adrienne E Dubin; Sandra R Chaplan; Alan D Wickenden
HCN channels as targets for drug discovery.
Combinatorial chemistry & high throughput screening 2009;12(1):64-72.
2009: Alec D Lebsack; Bryan J Branstetter; Michael D Hack; Wei Xiao; Matthew L Peterson; Nadia Nasser; Michael P Maher; Hong Ao; Anindya Bhattacharya; Mena Kansagara; Brian P Scott; Lin Luo; Raymond Rynberg; Michele Rizzolio; Sandra R Chaplan; Alan D Wickenden; J Guy Breitenbucher
Identification and synthesis of 2,7-diamino-thiazolo[5,4-d]pyrimidine derivatives as TRPV1 antagonists.
Bioorganic & medicinal chemistry letters 2009;19(1):40-6.
2008: Michael Maher; Hong Ao; Tue Banke; Nadia Nasser; Nyan-Tsz Wu; J Guy Breitenbucher; Sandra R Chaplan; Alan D Wickenden
Activation of TRPA1 by farnesyl thiosalicylic acid.
Molecular pharmacology 2008;73(4):1225-34.
2008: Amy Timmons; Mark Seierstad; Richard Apodaca; Matt Epperson; Dan Pippel; Sean Brown; Leon Chang; Brian Scott; Michael Webb; Sandra R Chaplan; J Guy Breitenbucher
Novel ketooxazole based inhibitors of fatty acid amide hydrolase (FAAH).
Bioorganic & medicinal chemistry letters 2008;18(6):2109-13.
2007: Anindya Bhattacharya; Brian P Scott; Nadia Nasser; Hong Ao; Michael P Maher; Adrienne E Dubin; Devin M Swanson; Nigel P Shankley; Alan D Wickenden; Sandra R Chaplan
Pharmacology and antitussive efficacy of 4-(3-trifluoromethyl-pyridin-2-yl)-piperazine-1-carboxylic acid (5-trifluoromethyl-pyridin-2-yl)-amide (JNJ17203212), a transient receptor potential vanilloid 1 antagonist in guinea pigs.
The Journal of pharmacology and experimental therapeutics 2007;323(2):665-74.
2007: Lin Luo; Leon Chang; Sean M Brown; Hong Ao; D H Lee; Emiliano S Higuera; Adrienne E Dubin; Sandra R Chaplan
Role of peripheral hyperpolarization-activated cyclic nucleotide-modulated channel pacemaker channels in acute and chronic pain models in the rat.
Neuroscience 2007;144(4):1477-85.
2006: Leon Chang; Lin Luo; James A Palmer; Steven Sutton; Sandy J Wilson; Ann J Barbier; J Guy Breitenbucher; Sandra R Chaplan; Michael Webb
Inhibition of fatty acid amide hydrolase produces analgesia by multiple mechanisms.
British journal of pharmacology 2006;148(1):102-13.
2005: Doo H Lee; Leon Chang; Linda S Sorkin; Sandra R Chaplan
Hyperpolarization-activated, cation-nonselective, cyclic nucleotide-modulated channel blockade alleviates mechanical allodynia and suppresses ectopic discharge in spinal nerve ligated rats.
The journal of pain : official journal of the American Pain Society 2005;6(7):417-24.
2005: Devin M Swanson; Adrienne E Dubin; Chandra Shah; Nadia Nasser; Leon Chang; Scott L Dax; Michele C Jetter; J Guy Breitenbucher; Changlu Liu; Curt Mazur; Brian Lord; Lisa Gonzales; Kenway Hoey; Michele Rizzolio; Michael Bogenstaetter; Ellen E Codd; Doo H Lee; Sui-Po Zhang; Sandra R Chaplan; Nicholas I Carruthers
Identification and biological evaluation of 4-(3-trifluoromethylpyridin-2-yl)piperazine-1-carboxylic acid (5-trifluoromethylpyridin-2-yl)amide, a high affinity TRPV1 (VR1) vanilloid receptor antagonist.
Journal of medicinal chemistry 2005;48(6):1857-72.
2005: Joseph R Ghilardi; Heidi Röhrich; Theodore H Lindsay; Molly A Sevcik; Matthew J Schwei; Kazufumi Kubota; Kyle G Halvorson; Jeannie Poblete; Sandra R Chaplan; Adrienne E Dubin; Nicholas I Carruthers; Devin Swanson; Michael Kuskowski; Christopher M Flores; David Julius; Patrick W Mantyh
Selective blockade of the capsaicin receptor TRPV1 attenuates bone cancer pain.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2005;25(12):3126-31.
2005: Adrienne E Dubin; Nadia Nasser; Jutta Rohrbacher; An Hermans; Roger Marrannes; Christopher Grantham; Koen Van Rossem; Miroslav Cik; Sandra R Chaplan; David Gallacher; Jia Xu; Antonio Guia; Nicholas G Byrne; Chris Mathes
Identifying modulators of hERG channel activity using the PatchXpress planar patch clamp.
Journal of biomolecular screening 2005;10(2):168-81.
2004: Sean M Brown; Adrienne E Dubin; Sandra R Chaplan
The role of pacemaker currents in neuropathic pain.
Pain practice : the official journal of World Institute of Pain 2004;4(3):182-93.
2004: Hong Qing Guo; Sandra R Chaplan
Semi-quantitative real-time PCR for pain research.
Methods in molecular medicine 2004;99():225-38.
2003: Sandra R Chaplan; Hong-Qing Guo; Doo Hyun Lee; Lin Luo; Changlu Liu; Chester Kuei; Alexander A Velumian; Matthew P Butler; Sean M Brown; Adrienne E Dubin
Neuronal hyperpolarization-activated pacemaker channels drive neuropathic pain.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2003;23(4):1169-78.
2001: N Nozaki-Taguchi; Sandra R Chaplan; Emiliano S Higuera; R C Ajakwe; Tony L Yaksh
Vincristine-induced allodynia in the rat.
Pain 2001;93(1):69-76.
2001: Z David Luo; Sandra R Chaplan; Emiliano S Higuera; Linda S Sorkin; K A Stauderman; M E Williams; Tony L Yaksh
Upregulation of dorsal root ganglion (alpha)2(delta) calcium channel subunit and its correlation with allodynia in spinal nerve-injured rats.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2001;21(6):1868-75.
2000: Sandra R Chaplan
Neuropathic pain: role of voltage-dependent calcium channels.
Regional anesthesia and pain medicine 2000;25(3):283-5.
1999: Z David Luo; Sandra R Chaplan; Brian P Scott; Dasa Cizkova; Nigel A Calcutt; Tony L Yaksh
Neuronal nitric oxide synthase mRNA upregulation in rat sensory neurons after spinal nerve ligation: lack of a role in allodynia development.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1999;19(21):9201-8.
1998: Matthew B Weinger; Sandra R Chaplan; B E Girten; Frank L Powell
The respiratory effects of the cytokine regulating agent HP 228 alone and in combination with morphine in human volunteers.
Pharmacology, biochemistry, and behavior 1998;59(3):759-66.
1998: B J Partridge; Sandra R Chaplan; E Sakamoto; Tony L Yaksh
Characterization of the effects of gabapentin and 3-isobutyl-gamma-aminobutyric acid on substance P-induced thermal hyperalgesia.
Anesthesiology 1998;88(1):196-205.
1997: Nigel A Calcutt; Sandra R Chaplan
Spinal pharmacology of tactile allodynia in diabetic rats.
British journal of pharmacology 1997;122(7):1478-82.
1997: S S Rossi; A C Moore; lee hagey; Tony L Yaksh; Sandra R Chaplan
An improved method for the measurement of lidocaine and its metabolites in rat plasma.
Therapeutic drug monitoring 1997;19(2):179-84.
1997: Sandra R Chaplan; Annika B Malmberg; Tony L Yaksh
Efficacy of spinal NMDA receptor antagonism in formalin hyperalgesia and nerve injury evoked allodynia in the rat.
The Journal of pharmacology and experimental therapeutics 1997;280(2):829-38.
1997: Kenji Okuse; Sandra R Chaplan; Stephen McMahon; Z David Luo; Nigel A Calcutt; Brian P Scott; Armen Akopian; John N Wood
Regulation of expression of the sensory neuron-specific sodium channel SNS in inflammatory and neuropathic pain.
Molecular and cellular neurosciences 1997;10(3-4):196-207.
1996: Nigel A Calcutt; M C Jorge; Tony L Yaksh; Sandra R Chaplan
Tactile allodynia and formalin hyperalgesia in streptozotocin-diabetic rats: effects of insulin, aldose reductase inhibition and lidocaine.
Pain 1996;68(2-3):293-9.
1995: Y W Lee; Sandra R Chaplan; Tony L Yaksh
Systemic and supraspinal, but not spinal, opiates suppress allodynia in a rat neuropathic pain model.
Neuroscience letters 1995;199(2):111-4.
1995: Sandra R Chaplan; F W Bach; Steven Shafer; Tony L Yaksh
Prolonged alleviation of tactile allodynia by intravenous lidocaine in neuropathic rats.
Anesthesiology 1995;83(4):775-85.
1995: F W Bach; Sandra R Chaplan; J Jang; Tony L Yaksh
Cerebrospinal fluid beta-endorphin in models of hyperalgesia in the rat.
Regulatory peptides 1995;59(1):79-86.
1995: Tony L Yaksh; Sandra R Chaplan; A B Malmberg
Future directions in the pharmacological management of hyperalgesic and allodynic pain states: the NMDA receptor.
NIDA research monograph 1995;147():84-103.
1995: Tony L Yaksh; J W Pogrel; Y W Lee; Sandra R Chaplan
Reversal of nerve ligation-induced allodynia by spinal alpha-2 adrenoceptor agonists.
The Journal of pharmacology and experimental therapeutics 1995;272(1):207-14.
1994: Sandra R Chaplan; F W Bach; J W Pogrel; J M Chung; Tony L Yaksh
Quantitative assessment of tactile allodynia in the rat paw.
Journal of neuroscience methods 1994;53(1):55-63.
1994: Sandra R Chaplan; J W Pogrel; Tony L Yaksh
Role of voltage-dependent calcium channel subtypes in experimental tactile allodynia.
The Journal of pharmacology and experimental therapeutics 1994;269(3):1117-23.