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Edwin Chapman

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TOP 3
Huisheng Liu; Edwin R Chapman; Camin Dean
"Self" versus "Non-Self" Connectivity Dictates Properties of Synaptic Transmission and Plasticity.
Sung E Kwon; Edwin R Chapman
Glycosylation is dispensable for sorting of synaptotagmin 1 but is critical for targeting of SV2 and synaptophysin to recycling synaptic vesicles.
Yao Wu; Jun Yao; Felix L Yeh; Min Dong; Yiwen Gu; Mary K Morphew; Edwin R Chapman
All three components of the neuronal SNARE complex contribute to secretory vesicle docking.

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All Publications

2013: Huisheng Liu; Edwin R Chapman; Camin Dean
"Self" versus "Non-Self" Connectivity Dictates Properties of Synaptic Transmission and Plasticity.
PloS one 2013;8(4):e62414.
2012: Sung E Kwon; Edwin R Chapman
Glycosylation is dispensable for sorting of synaptotagmin 1 but is critical for targeting of SV2 and synaptophysin to recycling synaptic vesicles.
The Journal of biological chemistry 2012;287(42):35658-68.
2012: Yao Wu; Jun Yao; Felix L Yeh; Min Dong; Yiwen Gu; Mary K Morphew; Edwin R Chapman
All three components of the neuronal SNARE complex contribute to secretory vesicle docking.
The Journal of cell biology 2012;198(3):323-30.
2012: Camin Dean; F Mark Dunning; Huisheng Liu; Henrik Martens; Saheeb Ahmed; Vinita Bharat; Ewa Bomba-Warczak; Edwin R Chapman
Axonal and dendritic synaptotagmin isoforms revealed by a pHluorin-syt functional screen.
Molecular biology of the cell 2012;23(9):1715-27.
2012: Jun Yao; F Mark Dunning; Jon D Gaffaney; Sung E Kwon; Edwin R Chapman
Uncoupling the roles of synaptotagmin I during endo- and exocytosis of synaptic vesicles.
Nature neuroscience 2012;15(2):243-9.
2011: Felix L Yeh; Yiming Zhu; Paul J Bertics; Eric A Johnson; William H Tepp; Edwin R Chapman
Retargeted clostridial neurotoxins as novel agents for treating chronic diseases.
Biochemistry 2011;50(48):10419-21.
2011: Jun Yao; Jon D Gaffaney; Sung E Kwon; Edwin R Chapman
Doc2 is a Ca2+ sensor required for asynchronous neurotransmitter release.
Cell 2011;147(3):666-77.
2011: Shihu Sun; Swetha Suresh; William H Tepp; J Michael Edwardson; Eric A Johnson; Huisheng Liu; Edwin R Chapman
Receptor binding enables botulinum neurotoxin B to sense low pH for translocation channel assembly.
Cell host & microbe 2011;10(3):237-47.
2011: Yao Wu; Hagan Bayley; Stephen Cheley; Qiang Cui; Liang Ma; Edwin R Chapman
Permeation of styryl dyes through nanometer-scale pores in membranes.
Biochemistry 2011;50(35):7493-502.
2011: Enfu Hui; Colin P Johnson; Zhao Wang; Chantell S Evans; Jon D Gaffaney; Edwin R Chapman
Mechanism and function of synaptotagmin-mediated membrane apposition.
Nature structural & molecular biology 2011;18(7):813-21.
2011: Zhen Zhang; Edwin R Chapman; F Mark Dunning; Deepshika Ramanan; Jonathan Rehfuss; Zhao Wang; Yao Wu; Meyer B Jackson
Release mode of large and small dense-core vesicles specified by different synaptotagmin isoforms in PC12 cells.
Molecular biology of the cell 2011;22(13):2324-36.
2011: Sung E Kwon; Edwin R Chapman
Synaptophysin regulates the kinetics of synaptic vesicle endocytosis in central neurons.
Neuron 2011;70(5):847-54.
2011: Dongsheng Wang; Zhen Zhang; Min Dong; Shihu Sun; Edwin R Chapman; Meyer B Jackson
Syntaxin requirement for Ca2+-triggered exocytosis in neurons and endocrine cells demonstrated with an engineered neurotoxin.
Biochemistry 2011;50(14):2711-3.
2010: Colin P Johnson; Edwin R Chapman
Otoferlin is a calcium sensor that directly regulates SNARE-mediated membrane fusion.
The Journal of cell biology 2010;191(1):187-97.
2010: Zhao Wang; Edwin R Chapman
Rat and Drosophila synaptotagmin 4 have opposite effects during SNARE-catalyzed membrane fusion.
The Journal of biological chemistry 2010;285(40):30759-66.
2010: Zhen Zhang; Enfu Hui; Edwin R Chapman; Meyer B Jackson
Regulation of exocytosis and fusion pores by synaptotagmin-effector interactions.
Molecular biology of the cell 2010;21(16):2821-31.
2010: Pål Stenmark; Min Dong; Jérôme Dupuy; Edwin R Chapman; Raymond C Stevens
Crystal structure of the botulinum neurotoxin type G binding domain: insight into cell surface binding.
Journal of molecular biology 2010;397(5):1287-97.
2010: Felix L Yeh; Min Dong; Jun Yao; William H Tepp; Guangyun Lin; Eric A Johnson; Edwin R Chapman
SV2 mediates entry of tetanus neurotoxin into central neurons.
PLoS pathogens 2010;6(11):e1001207.
2009: Zhen Zhang; Enfu Hui; Edwin R Chapman; Meyer B Jackson
Phosphatidylserine regulation of Ca2+-triggered exocytosis and fusion pores in PC12 cells.
Molecular biology of the cell 2009;20(24):5086-95.
2009: Enfu Hui; Colin P Johnson; Jun Yao; F Mark Dunning; Edwin R Chapman
Synaptotagmin-mediated bending of the target membrane is a critical step in Ca(2+)-regulated fusion.
Cell 2009;138(4):709-21.
2009: Yao Wu; Felix L Yeh; Fei Mao; Edwin R Chapman
Biophysical characterization of styryl dye-membrane interactions.
Biophysical journal 2009;97(1):101-9.
2009: Huisheng Liu; Camin Dean; Christopher P Arthur; Min Dong; Edwin R Chapman
Autapses and networks of hippocampal neurons exhibit distinct synaptic transmission phenotypes in the absence of synaptotagmin I.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2009;29(23):7395-403.
2009: Camin Dean; Huisheng Liu; F Mark Dunning; Payne Y Chang; Meyer B Jackson; Edwin R Chapman
Synaptotagmin-IV modulates synaptic function and long-term potentiation by regulating BDNF release.
Nature neuroscience 2009;12(6):767-76.
2009: Tingting Wang; Elizabeth A Smith; Edwin R Chapman; James C Weisshaar
Lipid mixing and content release in single-vesicle, SNARE-driven fusion assay with 1-5 ms resolution.
Biophysical journal 2009;96(10):4122-31.
2009: Michael C Chicka; Edwin R Chapman
Concurrent binding of complexin and synaptotagmin to liposome-embedded SNARE complexes.
Biochemistry 2009;48(4):657-9.
2009: Zhenjie Zhang; Akhil Bhalla; Camin Dean; Edwin R Chapman; Meyer B Jackson
Synaptotagmin IV: a multifunctional regulator of peptidergic nerve terminals.
Nature neuroscience 2009;12(2):163-71.
2008: Min Dong; Huisheng Liu; William H Tepp; Eric A Johnson; Roger Janz; Edwin R Chapman
Glycosylated SV2A and SV2B mediate the entry of botulinum neurotoxin E into neurons.
Molecular biology of the cell 2008;19(12):5226-37.
2008: Jon D Gaffaney; F Mark Dunning; Zhao Wang; Enfu Hui; Edwin R Chapman
Synaptotagmin C2B domain regulates Ca2+-triggered fusion in vitro: critical residues revealed by scanning alanine mutagenesis.
The Journal of biological chemistry 2008;283(46):31763-75.
2008: Michael C Chicka; Enfu Hui; Huisheng Liu; Edwin R Chapman
Synaptotagmin arrests the SNARE complex before triggering fast, efficient membrane fusion in response to Ca2+.
Nature structural & molecular biology 2008;15(8):827-35.
2008: Akhil Bhalla; Michael C Chicka; Edwin R Chapman
Analysis of the synaptotagmin family during reconstituted membrane fusion. Uncovering a class of inhibitory isoforms.
The Journal of biological chemistry 2008;283(31):21799-807.
2008: Meyer B Jackson; Edwin R Chapman
The fusion pores of Ca2+ -triggered exocytosis.
Nature structural & molecular biology 2008;15(7):684-9.
2008: Victor Shahin; Debajyoti Datta; Enfu Hui; Robert Henderson; Edwin R Chapman; J Michael Edwardson
Synaptotagmin perturbs the structure of phospholipid bilayers.
Biochemistry 2008;47(7):2143-52.
2008: Tingting Liu; Tingting Wang; Edwin R Chapman; James C Weisshaar
Productive hemifusion intermediates in fast vesicle fusion driven by neuronal SNAREs.
Biophysical journal 2008;94(4):1303-14.
2008: Edwin R Chapman
How does synaptotagmin trigger neurotransmitter release?
Annual review of biochemistry 2008;77():615-41.
2007: Min Dong; William H Tepp; Huisheng Liu; Eric A Johnson; Edwin R Chapman
Mechanism of botulinum neurotoxin B and G entry into hippocampal neurons.
The Journal of cell biology 2007;179(7):1511-22.
2006: Qing Chai; Joseph W Arndt; Min Dong; William H Tepp; Eric A Johnson; Edwin R Chapman; Raymond C Stevens
Structural basis of cell surface receptor recognition by botulinum neurotoxin B.
Nature 2006;444(7122):1096-100.
2006: Cecilia Czibener; Nathan M Sherer; Steven M Becker; Marc Pypaert; Enfu Hui; Edwin R Chapman; Walther Mothes; Norma W Andrews
Ca2+ and synaptotagmin VII-dependent delivery of lysosomal membrane to nascent phagosomes.
The Journal of cell biology 2006;174(7):997-1007.
2006: Enfu Hui; Jihong Bai; Edwin R Chapman
Ca2+-triggered simultaneous membrane penetration of the tandem C2-domains of synaptotagmin I.
Biophysical journal 2006;91(5):1767-77.
2006: Min Dong; Felix Yeh; William H Tepp; Camin Dean; Eric A Johnson; Roger Janz; Edwin R Chapman
SV2 is the protein receptor for botulinum neurotoxin A.
Science (New York, N.Y.) 2006;312(5773):592-6.
2006: Akhil Bhalla; Michael C Chicka; Ward C Tucker; Edwin R Chapman
Ca(2+)-synaptotagmin directly regulates t-SNARE function during reconstituted membrane fusion.
Nature structural & molecular biology 2006;13(4):323-30.
2006: Chih-Tien Wang; Jihong Bai; Payne Y Chang; Edwin R Chapman; Meyer B Jackson
Synaptotagmin-Ca2+ triggers two sequential steps in regulated exocytosis in rat PC12 cells: fusion pore opening and fusion pore dilation.
The Journal of physiology 2006;570(Pt 2):295-307.
2006: Meyer B Jackson; Edwin R Chapman
Fusion pores and fusion machines in Ca2+-triggered exocytosis.
Annual review of biophysics and biomolecular structure 2006;35():135-60.
2005: Ping Wang; Michael C Chicka; Akhil Bhalla; David A Richards; Edwin R Chapman
Synaptotagmin VII is targeted to secretory organelles in PC12 cells, where it functions as a high-affinity calcium sensor.
Molecular and cellular biology 2005;25(19):8693-702.
2005: Akhil Bhalla; Ward C Tucker; Edwin R Chapman
Synaptotagmin isoforms couple distinct ranges of Ca2+, Ba2+, and Sr2+ concentration to SNARE-mediated membrane fusion.
Molecular biology of the cell 2005;16(10):4755-64.
2005: Tingting Liu; Ward C Tucker; Akhil Bhalla; Edwin R Chapman; James C Weisshaar
SNARE-driven, 25-millisecond vesicle fusion in vitro.
Biophysical journal 2005;89(4):2458-72.
2005: Enfu Hui; Jihong Bai; Ping Wang; Mutsuyuki Sugimori; Rodolfo R Llinas; Edwin R Chapman
Three distinct kinetic groupings of the synaptotagmin family: candidate sensors for rapid and delayed exocytosis.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(14):5210-4.
2005: David A Richards; Jihong Bai; Edwin R Chapman
Two modes of exocytosis at hippocampal synapses revealed by rate of FM1-43 efflux from individual vesicles.
The Journal of cell biology 2005;168(6):929-39.
2005: Michael T Madziva; Jihong Bai; Akhil Bhalla; Edwin R Chapman; J Michael Edwardson
Effects of synaptotagmin reveal two distinct mechanisms of agonist-stimulated internalization of the M4 muscarinic acetylcholine receptor.
British journal of pharmacology 2005;144(6):761-71.
2005: Sheldon S Shen; Ward C Tucker; Edwin R Chapman; Richard A Steinhardt
Molecular regulation of membrane resealing in 3T3 fibroblasts.
The Journal of biological chemistry 2005;280(2):1652-60.
2004: Min Dong; William H Tepp; Eric A Johnson; Edwin R Chapman
Using fluorescent sensors to detect botulinum neurotoxin activity in vitro and in living cells.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(41):14701-6.
2004: Ruslan Grishanin; Judith A Kowalchyk; Vadim A Klenchin; Kyoungsook Ann; Cynthia A Earles; Edwin R Chapman; Roy R L Gerona; Thomas F J Martin
CAPS acts at a prefusion step in dense-core vesicle exocytosis as a PIP2 binding protein.
Neuron 2004;43(4):551-62.
2004: Bakhrom K Berdiev; Biljana Jovov; Ward C Tucker; Anjaparavanda P Naren; Catherine M Fuller; Edwin R Chapman; Dale J Benos
ENaC subunit-subunit interactions and inhibition by syntaxin 1A.
American journal of physiology. Renal physiology 2004;286(6):F1100-6.
2004: Ward C Tucker; Thomas Weber; Edwin R Chapman
Reconstitution of Ca2+-regulated membrane fusion by synaptotagmin and SNAREs.
Science (New York, N.Y.) 2004;304(5669):435-8.
2004: Xue Han; Chih-Tien Wang; Jihong Bai; Edwin R Chapman; Meyer B Jackson
Transmembrane segments of syntaxin line the fusion pore of Ca2+-triggered exocytosis.
Science (New York, N.Y.) 2004;304(5668):289-92.
2004: Evelina Chieregatti; Michael C Chicka; Edwin R Chapman; Giovanna Baldini
SNAP-23 functions in docking/fusion of granules at low Ca2+.
Molecular biology of the cell 2004;15(4):1918-30.
2004: Jihong Bai; Chih-Tien Wang; David A Richards; Meyer B Jackson; Edwin R Chapman
Fusion pore dynamics are regulated by synaptotagmin*t-SNARE interactions.
Neuron 2004;41(6):929-42.
2004: Jihong Bai; Edwin R Chapman
The C2 domains of synaptotagmin--partners in exocytosis.
Trends in biochemical sciences 2004;29(3):143-51.
2004: Jihong Bai; Ward C Tucker; Edwin R Chapman
PIP2 increases the speed of response of synaptotagmin and steers its membrane-penetration activity toward the plasma membrane.
Nature structural & molecular biology 2004;11(1):36-44.
2003: Ping Wang; Chih-Tien Wang; Jihong Bai; Meyer B Jackson; Edwin R Chapman
Mutations in the effector binding loops in the C2A and C2B domains of synaptotagmin I disrupt exocytosis in a nonadditive manner.
The Journal of biological chemistry 2003;278(47):47030-7.
2003: Min Dong; David A Richards; Michael C Goodnough; William H Tepp; Eric A Johnson; Edwin R Chapman
Synaptotagmins I and II mediate entry of botulinum neurotoxin B into cells.
The Journal of cell biology 2003;162(7):1293-303.
2003: Chih-Tien Wang; Juu-Chin Lu; Jihong Bai; Payne Y Chang; Thomas F J Martin; Edwin R Chapman; Meyer B Jackson
Different domains of synaptotagmin control the choice between kiss-and-run and full fusion.
Nature 2003;424(6951):943-7.
2003: J Michael Edwardson; Chih-Tien Wang; Belvin Gong; Andreas Wyttenbach; Jihong Bai; Meyer B Jackson; Edwin R Chapman; A Jennifer Morton
Expression of mutant huntingtin blocks exocytosis in PC12 cells by depletion of complexin II.
The Journal of biological chemistry 2003;278(33):30849-53.
2003: Ward C Tucker; J Michael Edwardson; Jihong Bai; Hyun-Jung Kim; Thomas F J Martin; Edwin R Chapman
Identification of synaptotagmin effectors via acute inhibition of secretion from cracked PC12 cells.
The Journal of cell biology 2003;162(2):199-209.
2003: Yi Wu; Yuhong He; Jihong Bai; Shang-Rong Ji; Ward C Tucker; Edwin R Chapman; Sen-Fang Sui
Visualization of synaptotagmin I oligomers assembled onto lipid monolayers.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(4):2082-7.
2003: Jihong Bai; Edwin R Chapman
Application of fluorescent probes to study mechanics and dynamics of Ca2+-triggered synaptotagmin C2 domain-membrane interactions.
Methods in enzymology 2003;360():238-58.
2002: Ward C Tucker; Edwin R Chapman
Role of synaptotagmin in Ca2+-triggered exocytosis.
The Biochemical journal 2002;366(Pt 1):1-13.
2002: Edwin R Chapman
Synaptotagmin: a Ca(2+) sensor that triggers exocytosis?
Nature reviews. Molecular cell biology 2002;3(7):498-508.
2002: Jihong Bai; Ping Wang; Edwin R Chapman
C2A activates a cryptic Ca(2+)-triggered membrane penetration activity within the C2B domain of synaptotagmin I.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(3):1665-70.
2001: Chih-Tien Wang; Ruslan Grishanin; Cynthia A Earles; Payne Y Chang; Thomas F J Martin; Edwin R Chapman; Meyer B Jackson
Synaptotagmin modulation of fusion pore kinetics in regulated exocytosis of dense-core vesicles.
Science (New York, N.Y.) 2001;294(5544):1111-5.
2001: J Troy Littleton; R J Barnard; Steven A Titus; J Slind; Edwin R Chapman; Barry Ganetzky
SNARE-complex disassembly by NSF follows synaptic-vesicle fusion.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(21):12233-8.
2001: Cynthia A Earles; Jihong Bai; Ping Wang; Edwin R Chapman
The tandem C2 domains of synaptotagmin contain redundant Ca2+ binding sites that cooperate to engage t-SNAREs and trigger exocytosis.
The Journal of cell biology 2001;154(6):1117-23.
2001: JL Lewis; M Dong; Cynthia A Earles; Edwin R Chapman
The transmembrane domain of syntaxin 1A is critical for cytoplasmic domain protein-protein interactions.
The Journal of biological chemistry 2001;276(18):15458-65.
2001: J Troy Littleton; J Bai; B Vyas; R Desai; A E Baltus; MB Garment; SD Carlson; Barry Ganetzky; Edwin R Chapman
synaptotagmin mutants reveal essential functions for the C2B domain in Ca2+-triggered fusion and recycling of synaptic vesicles in vivo.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2001;21(5):1421-33.
2000: Volker Haucke; Markus R Wenk; Edwin R Chapman; Khashayar Farsad; Pietro De Camilli
Dual interaction of synaptotagmin with mu2- and alpha-adaptin facilitates clathrin-coated pit nucleation.
The EMBO journal 2000;19(22):6011-9.
2000: R C Desai; B Vyas; Cynthia A Earles; J Troy Littleton; J A Kowalchyck; Thomas F J Martin; Edwin R Chapman
The C2B domain of synaptotagmin is a Ca(2+)-sensing module essential for exocytosis.
The Journal of cell biology 2000;150(5):1125-36.
2000: Jihong Bai; Cynthia A Earles; JL Lewis; Edwin R Chapman
Membrane-embedded synaptotagmin penetrates cis or trans target membranes and clusters via a novel mechanism.
The Journal of biological chemistry 2000;275(33):25427-35.
1999: AF Davis; Jihong Bai; D Fasshauer; M J Wolowick; JL Lewis; Edwin R Chapman
Kinetics of synaptotagmin responses to Ca2+ and assembly with the core SNARE complex onto membranes.
Neuron 1999;24(2):363-76.
1999: J Troy Littleton; T L Serano; G M Rubin; Barry Ganetzky; Edwin R Chapman
Synaptic function modulated by changes in the ratio of synaptotagmin I and IV.
Nature 1999;400(6746):757-60.
1998: Edwin R Chapman; R C Desai; AF Davis; C K Tornehl
Delineation of the oligomerization, AP-2 binding, and synprint binding region of the C2B domain of synaptotagmin.
The Journal of biological chemistry 1998;273(49):32966-72.
1998: J Troy Littleton; Edwin R Chapman; Robert Kreber; MB Garment; SD Carlson; Barry Ganetzky
Temperature-sensitive paralytic mutations demonstrate that synaptic exocytosis requires SNARE complex assembly and disassembly.
Neuron 1998;21(2):401-13.
1998: Edwin R Chapman; AF Davis
Direct interaction of a Ca2+-binding loop of synaptotagmin with lipid bilayers.
The Journal of biological chemistry 1998;273(22):13995-4001.