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Hiromi Abe

Research Profile

Living Beings

Chemicals & Drugs

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Anatomy

Hepatocytes

Genes & Molecular Sequences

Single Nucleotide Polymorphism

Physiology

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Drug Therapy, Combination

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Publications

TOP 3
Keiko Arataki; Hiromi Abe; Hiroshi Aikata; Sakura Akamatsu; Rie Akiyama; C Nelson Hayes; Nobuhiko Hiraga; Michio Imamura; Hiroiku Kawakami; Tomokazu Kawaoka; Daiki Miki; Hidenori Ochi; Waka Ohishi; Shoichi Takahashi; Masataka Tsuge; Kazuaki Chayama
Circulating microRNA-22 correlates with microRNA-122 and represents viral replication and liver injury in patients with chronic hepatitis B.
Yuji Urabe; Hiromi Abe; Kazuaki Chayama; Naoya Hosono; Naoyuki Kamatani; Naoya Kato; Kazuhiko Koike; Michiaki Kubo; Hiromitsu Kumada; Vinod Kumar; Paulisally Hau Yi Lo; Daiki Miki; Ryosuke Muroyama; Yusuke Nakamura; Hidenori Ochi; Masao Omata; Motoyuki Otsuka; Atsushi Takahashi; Chizu Tanikawa; Ryosuke Tateishi; Joji Toyota; Koichi Matsuda
A genome-wide association study of HCV-induced liver cirrhosis in the Japanese population identifies novel susceptibility loci at the MHC region.
Akihito Okazaki; Shoichi Takahashi; Chise Tateno; Masataka Tsuge; Katsutoshi Yoshizato; C Nelson Hayes; Nobuhiko Hiraga; Michio Imamura; Daiki Miki; Hidenori Ochi; Hideki Ohdan; Hiromi Abe; Hiroshi Aikata; Kazuaki Chayama
Severe necroinflammatory reaction caused by natural killer cell-mediated Fas/Fas ligand interaction and dendritic cells in human hepatocyte chimeric mouse.

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All Publications

2013: Keiko Arataki; Hiromi Abe; Hiroshi Aikata; Sakura Akamatsu; Rie Akiyama; C Nelson Hayes; Nobuhiko Hiraga; Michio Imamura; Hiroiku Kawakami; Tomokazu Kawaoka; Daiki Miki; Hidenori Ochi; Waka Ohishi; Shoichi Takahashi; Masataka Tsuge; Kazuaki Chayama
Circulating microRNA-22 correlates with microRNA-122 and represents viral replication and liver injury in patients with chronic hepatitis B.
Journal of medical virology 2013;85(5):789-98.
2013: Yuji Urabe; Hiromi Abe; Kazuaki Chayama; Naoya Hosono; Naoyuki Kamatani; Naoya Kato; Kazuhiko Koike; Michiaki Kubo; Hiromitsu Kumada; Vinod Kumar; Paulisally Hau Yi Lo; Daiki Miki; Ryosuke Muroyama; Yusuke Nakamura; Hidenori Ochi; Masao Omata; Motoyuki Otsuka; Atsushi Takahashi; Chizu Tanikawa; Ryosuke Tateishi; Joji Toyota; Koichi Matsuda
A genome-wide association study of HCV-induced liver cirrhosis in the Japanese population identifies novel susceptibility loci at the MHC region.
Journal of hepatology 2013;58(5):875-82.
2012: Akihito Okazaki; Shoichi Takahashi; Chise Tateno; Masataka Tsuge; Katsutoshi Yoshizato; C Nelson Hayes; Nobuhiko Hiraga; Michio Imamura; Daiki Miki; Hidenori Ochi; Hideki Ohdan; Hiromi Abe; Hiroshi Aikata; Kazuaki Chayama
Severe necroinflammatory reaction caused by natural killer cell-mediated Fas/Fas ligand interaction and dendritic cells in human hepatocyte chimeric mouse.
Hepatology (Baltimore, Md.) 2012;56(2):555-66.
2012: Mayu Ohnishi; Shoichi Takahashi; Shinji Tanaka; Masataka Tsuge; Yizhou Zhang; Hiromi Abe; Koji Arihiro; C Nelson Hayes; Nobuhiko Hiraga; Hideyuki Hyogo; Michio Imamura; Yuki Kimura; Tomohiko Kohno; Daiki Miki; Hidenori Ochi; Kazuaki Chayama
IL28B polymorphism is associated with fatty change in the liver of chronic hepatitis C patients.
Journal of gastroenterology 2012;47(7):834-44.
2012: Norimitsu Morioka; Yoki Nakamura; Hiromi Abe; Toshihiro Dohi; Kazue Hisaoka; Tatsuhiko Sugimoto; Masato Tokuhara; Yoshihiro Nakata
Spinal astrocytes contribute to the circadian oscillation of glutamine synthase, cyclooxygenase-1 and clock genes in the lumbar spinal cord of mice.
Neurochemistry international 2012;60(8):817-26.
2012: C Nelson Hayes; Nobuhiko Hiraga; Michio Imamura; Yoshiiku Kawakami; Tomokazu Kawaoka; Daiki Miki; Hidenori Ochi; Waka Ohishi; Shoichi Takahashi; Masataka Tsuge; Hiromi Abe; Hiroshi Aikata; Sakura Akamatsu; Rie Akiyama; Kazuaki Chayama
Hepatitis B virus-specific miRNAs and Argonaute2 play a role in the viral life cycle.
PloS one 2012;7(10):e47490.
2012: Tomohiko Kohno; Daiki Miki; Hidenori Ochi; Mayu Ohnishi; Shoichi Takahashi; Shinji Tanaka; Masataka Tsuge; Tsuyoshi Hatakeyama; C Nelson Hayes; Nobuhiko Hiraga; Michio Imamura; Hiromi Abe; Kazuaki Chayama
Identification of novel HCV deletion mutants in chronic hepatitis C patients.
Antiviral therapy 2012;17(8):1551-61.
2011: Hiromi Abe; C Nelson Hayes; Nobuhiko Hiraga; Michio Imamura; Naoyuki Kamatani; Michiaki Kubo; Daiki Miki; Yusuke Nakamura; Hidenori Ochi; Shoichi Takahashi; Masataka Tsuge; Kazuaki Chayama
Inverse association of IL28B genotype and liver mRNA expression of genes promoting or suppressing antiviral state.
Journal of medical virology 2011;83(9):1597-607.
2011: Daiki Miki; Takashi Morizono; Yusuke Nakamura; Hidenori Ochi; Joji Toyota; Tatsuhiko Tsunoda; Tadahiko Yoshima; C Nelson Hayes; Kenji Ikeda; Naoyuki Kamatani; Michiaki Kubo; Hiromitsu Kumada; Hiromi Abe; Hiroshi Aikata; Kazuaki Chayama
Variation in the DEPDC5 locus is associated with progression to hepatocellular carcinoma in chronic hepatitis C virus carriers.
Nature genetics 2011;43(8):797-800.
2011: Masataka Tsuge; Yizhou Zhang; Hiromi Abe; Yoshifumi Fujimoto; C Nelson Hayes; Nobuhiko Hiraga; Michio Imamura; Tomokazu Kawaoka; Fukiko Mitsui; Hidenori Ochi; Shoichi Takahashi; Kazuaki Chayama
Effects of hepatitis B virus infection on the interferon response in immunodeficient human hepatocyte chimeric mice.
The Journal of infectious diseases 2011;204(2):224-8.
2011: Kazuaki Chayama; C Nelson Hayes; Hiromi Abe; Daiki Miki; Hidenori Ochi; Yoshiyasu Karino; Joji Toyota; Yusuke Nakamura; Naoyuki Kamatani; Hitomi Sezaki; Mariko Kobayashi; Norio Akuta; Fumitaka Suzuki; Hiromitsu Kumada
IL28B but not ITPA polymorphism is predictive of response to pegylated interferon, ribavirin, and telaprevir triple therapy in patients with genotype 1 hepatitis C.
The Journal of infectious diseases 2011;204(1):84-93.
2011: Hiromi Abe; Kenji Asai; C Nelson Hayes; Nobuhiko Hiraga; Michio Imamura; Tomokazu Kawaoka; Toshiro Maekawa; Takashi Matsuhira; Fukiko Mitsui; Shoichi Murakami; Hidenori Ochi; Shoichi Takahashi; Chise Tateno; Masataka Tsuge; Nobuyuki Yamashita; Katsutoshi Yoshizato; Kazuaki Chayama
ME3738 enhances the effect of interferon and inhibits hepatitis C virus replication both in vitro and in vivo.
Journal of hepatology 2011;55(1):11-8.
2011: Takahiro Azakami; C Nelson Hayes; Hitomi Sezaki; Mariko Kobayashi; Norio Akuta; Fumitaka Suzuki; Hiromitsu Kumada; Hiromi Abe; Daiki Miki; Masataka Tsuge; Michio Imamura; Yoshiiku Kawakami; Shoichi Takahashi; Hidenori Ochi; Yusuke Nakamura; Naoyuki Kamatani; Kazuaki Chayama
Common genetic polymorphism of ITPA gene affects ribavirin-induced anemia and effect of peg-interferon plus ribavirin therapy.
Journal of medical virology 2011;83(6):1048-57.
2011: Yoshimasa Hashimoto; Hidenori Ochi; Hiromi Abe; Yasufumi Hayashida; Masataka Tsuge; Fukiko Mitsui; Nobuhiko Hiraga; Michio Imamura; Shoichi Takahashi; C Nelson Hayes; Waka Ohishi; Michaki Kubo; Tatsuhiko Tsunoda; Naoyuki Kamatani; Yusuke Nakamura; Kazuaki Chayama
Prediction of response to peginterferon-alfa-2b plus ribavirin therapy in Japanese patients infected with hepatitis C virus genotype 1b.
Journal of medical virology 2011;83(6):981-8.
2011: Hiromi Abe; C Nelson Hayes; Hidenori Ochi; Toshiro Maekawa; Masataka Tsuge; Daiki Miki; Fukiko Mitsui; Nobuhiko Hiraga; Michio Imamura; Shoichi Takahashi; Michiaki Kubo; Yusuke Nakamura; Kazuaki Chayama
IL28 variation affects expression of interferon stimulated genes and peg-interferon and ribavirin therapy.
Journal of hepatology 2011;54(6):1094-101.
2011: Hidenori Ochi; Toshiro Maekawa; Hiromi Abe; Yasufumi Hayashida; Rikita Nakano; Michio Imamura; Nobuhiko Hiraga; Yoshiiku Kawakami; Shiomi Aimitsu; Jia-Horng Kao; Michiaki Kubo; Tatsuhiko Tsunoda; Hiromitsu Kumada; Yusuke Nakamura; C Nelson Hayes; Kazuaki Chayama
IL-28B predicts response to chronic hepatitis C therapy--fine-mapping and replication study in Asian populations.
The Journal of general virology 2011;92(Pt 5):1071-81.
2011: Eiji Ohara; Nobuhiko Hiraga; Michio Imamura; Eiji Iwao; Naohiro Kamiya; Ichimaro Yamada; Tomohiko Kono; Mayu Onishi; Daizaburo Hirata; Fukiko Mitsui; Tomokazu Kawaoka; Masataka Tsuge; Shoichi Takahashi; Hiromi Abe; C Nelson Hayes; Hidenori Ochi; Chise Tateno; Katsutoshi Yoshizato; Shinji Tanaka; Kazuaki Chayama
Elimination of hepatitis C virus by short term NS3-4A and NS5B inhibitor combination therapy in human hepatocyte chimeric mice.
Journal of hepatology 2011;54(5):872-8.
2011: Yoshifumi Fujimoto; Hidenori Ochi; Toshiro Maekawa; Hiromi Abe; C Nelson Hayes; Hiromitsu Kumada; Yusuke Nakamura; Kazuaki Chayama
A single nucleotide polymorphism in activated Cdc42 associated tyrosine kinase 1 influences the interferon therapy in hepatitis C patients.
Journal of hepatology 2011;54(4):629-39.
2011: Tomokazu Kawaoka; C Nelson Hayes; Waka Ohishi; Hidenori Ochi; Toshiro Maekawa; Hiromi Abe; Masataka Tsuge; Fukiko Mitsui; Nobuhiko Hiraga; Michio Imamura; Shoichi Takahashi; Michaki Kubo; Tatsuhiko Tsunoda; Yusuke Nakamura; Hiromitsu Kumada; Kazuaki Chayama
Predictive value of the IL28B polymorphism on the effect of interferon therapy in chronic hepatitis C patients with genotypes 2a and 2b.
Journal of hepatology 2011;54(3):408-14.
2011: C Nelson Hayes; Mariko Kobayashi; Norio Akuta; Fumitaka Suzuki; Hiromitsu Kumada; Hiromi Abe; Daiki Miki; Michio Imamura; Hidenori Ochi; Naoyuki Kamatani; Yusuke Nakamura; Kazuaki Chayama
HCV substitutions and IL28B polymorphisms on outcome of peg-interferon plus ribavirin combination therapy.
Gut 2011;60(2):261-7.
2011: Masataka Tsuge; Tatsuhiko Tsunoda; Yizhou Zhang; Hiromi Abe; Yoshifumi Fujimoto; C Nelson Hayes; Nobuhiko Hiraga; Michio Imamura; Tomohiko Kohno; Daiki Miki; Fuyuki Miya; Hidenori Ochi; Mayu Ohnishi; Shoichi Takahashi; Kazuaki Chayama
Hepatitis C virus infection suppresses the interferon response in the liver of the human hepatocyte chimeric mouse.
PloS one 2011;6(8):e23856.
2011: Kazuaki Chayama; C Nelson Hayes; Nobuhiko Hiraga; Hiromi Abe; Masataka Tsuge; Michio Imamura
Animal model for study of human hepatitis viruses.
Journal of gastroenterology and hepatology 2011;26(1):13-8.
2010: Hidenori Ochi; Toshiro Maekawa; Hiromi Abe; Yasufumi Hayashida; Rikita Nakano; Michaki Kubo; Tatsuhiko Tsunoda; C Nelson Hayes; Hiromitsu Kumada; Yusuke Nakamura; Kazuaki Chayama
ITPA polymorphism affects ribavirin-induced anemia and outcomes of therapy--a genome-wide study of Japanese HCV virus patients.
Gastroenterology 2010;139(4):1190-7.
2010: Fukiko Mitsui; Masataka Tsuge; Takashi Kimura; Shosuke Kitamura; Hiromi Abe; Hiromi Saneto; Tomokazu Kawaoka; Daiki Miki; Tsuyoshi Hatakeyama; Nobuhiko Hiraga; Michio Imamura; Yoshiiku Kawakami; Hiroshi Aikata; Shoichi Takahashi; C Nelson Hayes; Harue Igarashi; Kentaro Morimoto; Masao Shimizu; Kazuaki Chayama
Importance of serum concentration of adefovir for Lamivudine-adefovir combination therapy in patients with lamivudine-resistant chronic hepatitis B.
Antimicrobial agents and chemotherapy 2010;54(8):3205-11.
2010: Masataka Tsuge; Nobuhiko Hiraga; Rie Akiyama; Sachi Tanaka; Miyuki Matsushita; Fukiko Mitsui; Hiromi Abe; Shosuke Kitamura; Tsuyoshi Hatakeyama; Takashi Kimura; Daiki Miki; Nami Mori; Michio Imamura; Shoichi Takahashi; C Nelson Hayes; Kazuaki Chayama
HBx protein is indispensable for development of viraemia in human hepatocyte chimeric mice.
The Journal of general virology 2010;91(Pt 7):1854-64.
2010: Masataka Tsuge; Chiemi Noguchi; Rie Akiyama; Miyuki Matsushita; Kana Kunihiro; Sachi Tanaka; Hiromi Abe; Fukiko Mitsui; Shosuke Kitamura; Tsuyoshi Hatakeyama; Takashi Kimura; Daiki Miki; Nobuhiko Hiraga; Michio Imamura; Shoichi Takahashi; C Nelson Hayses; Kazuaki Chayama
G to A hypermutation of TT virus.
Virus research 2010;149(2):211-6.
2010: Shosuke Kitamura; Masataka Tsuge; Tsuyoshi Hatakeyama; Hiromi Abe; Michio Imamura; Nami Mori; Hiromi Saneto; Tomokazu Kawaoka; Fukiko Mitsui; Nobuhiko Hiraga; Shintaro Takaki; Yoshiiku Kawakami; Hiroshi Aikata; Shoichi Takahashi; Waka Ohishi; Hidenori Ochi; C Nelson Hayes; Kazuaki Chayama
Amino acid substitutions in core and NS5A regions of the HCV genome can predict virological decrease with pegylated interferon plus ribavirin therapy.
Antiviral therapy 2010;15(8):1087-97.
2009: Nobuhiko Hiraga; Michio Imamura; Tsuyoshi Hatakeyama; Shosuke Kitamura; Fukiko Mitsui; Shinji Tanaka; Masataka Tsuge; Shoichi Takahashi; Hiromi Abe; Toshiro Maekawa; Hidenori Ochi; Chise Tateno; Katsutoshi Yoshizato; Takaji Wakita; Kazuaki Chayama
Absence of viral interference and different susceptibility to interferon between hepatitis B virus and hepatitis C virus in human hepatocyte chimeric mice.
Journal of hepatology 2009;51(6):1046-54.
2009: Chiemi Noguchi; Michio Imamura; Masataka Tsuge; Nobuhiko Hiraga; Nami Mori; Daiki Miki; Takashi Kimura; Shoichi Takahashi; Yoshifumi Fujimoto; Hidenori Ochi; Hiromi Abe; Toshiro Maekawa; Chise Tateno; Katsutoshi Yoshizato; Kazuaki Chayama
G-to-A hypermutation in hepatitis B virus (HBV) and clinical course of patients with chronic HBV infection.
The Journal of infectious diseases 2009;199(11):1599-607.
2008: Takashi Kimura; Michio Imamura; Nobuhiko Hiraga; Tsuyoshi Hatakeyama; Daiki Miki; Chiemi Noguchi; Nami Mori; Masataka Tsuge; Shoichi Takahashi; Yoshifumi Fujimoto; Eiji Iwao; Hidenori Ochi; Hiromi Abe; Toshiro Maekawa; Keiko Arataki; Chise Tateno; Katsutoshi Yoshizato; Takaji Wakita; Toru Okamoto; Y Matsuura; Kazuaki Chayama
Establishment of an infectious genotype 1b hepatitis C virus clone in human hepatocyte chimeric mice.
The Journal of general virology 2008;89(Pt 9):2108-13.
2007: Hiromi Yatsuji; Nobuhiko Hiraga; Nami Mori; Tsuyoshi Hatakeyama; Masataka Tsuge; Michio Imamura; Shoichi Takahashi; Yoshifumi Fujimoto; Hidenori Ochi; Hiromi Abe; Toshiro Maekawa; Fumitaka Suzuki; Hiromitsu Kumada; Kazuaki Chayama
Successful treatment of an entecavir-resistant hepatitis B virus variant.
Journal of medical virology 2007;79(12):1811-7.
2007: Nobuhiko Hiraga; Michio Imamura; Masataka Tsuge; Chiemi Noguchi; Shoichi Takahashi; Eiji Iwao; Yoshifumi Fujimoto; Hiromi Abe; Toshiro Maekawa; Hidenori Ochi; Chise Tateno; Katsutoshi Yoshizato; Akihito Sakai; Yoshio Sakai; Masao Honda; Shuichi Kaneko; Takaji Wakita; Kazuaki Chayama
Infection of human hepatocyte chimeric mouse with genetically engineered hepatitis C virus and its susceptibility to interferon.
FEBS letters 2007;581(10):1983-7.
2007: Tsuyoshi Hatakeyama; Chiemi Noguchi; Nobuhiko Hiraga; Nami Mori; Masataka Tsuge; Michio Imamura; Shoichi Takahashi; Yoshiiku Kawakami; Yoshifumi Fujimoto; Hidenori Ochi; Hiromi Abe; Toshiro Maekawa; Hiroiku Kawakami; Hiromi Yatsuji; Yasuyuki Aisaka; Hiroshi Kohno; Shiomi Aimitsu; Kazuaki Chayama
Serum HBV RNA is a predictor of early emergence of the YMDD mutant in patients treated with lamivudine.
Hepatology (Baltimore, Md.) 2007;45(5):1179-86.
2007: Chiemi Noguchi; Nobuhiko Hiraga; Nami Mori; Masataka Tsuge; Michio Imamura; Shoichi Takahashi; Yoshifumi Fujimoto; Hidenori Ochi; Hiromi Abe; Toshiro Maekawa; Hiromi Yatsuji; Kotaro Shirakawa; Akifumi Takaori-Kondo; Kazuaki Chayama
Dual effect of APOBEC3G on Hepatitis B virus.
The Journal of general virology 2007;88(Pt 2):432-40.
2006: Hiromi Yatsuji; Chiemi Noguchi; Nobuhiko Hiraga; Nami Mori; Masataka Tsuge; Michio Imamura; Shoichi Takahashi; Eiji Iwao; Yoshifumi Fujimoto; Hidenori Ochi; Hiromi Abe; Toshiro Maekawa; Chise Tateno; Katsutoshi Yoshizato; Fumitaka Suzuki; Hiromitsu Kumada; Kazuaki Chayama
Emergence of a novel lamivudine-resistant hepatitis B virus variant with a substitution outside the YMDD motif.
Antimicrobial agents and chemotherapy 2006;50(11):3867-74.