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Paulette Charlier

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Pablo Power; Paulette Charlier; Georges Dive; Moreno Galleni; Gabriel Gutkind; Raphaël Herman; Frédéric Kerff; Paola Sandra Mercuri; Eric Sauvage
Novel fragments of clavulanate observed in the structure of the class A β-lactamase from Bacillus licheniformis BS3.
Astrid Zervosen; Eric Sauvage; Ana Amoroso; André Bouillez; Paulette Charlier; Alexandre Herman; Bernard Joris; André Luxen
Synthesis and evaluation of boronic acids as inhibitors of Penicillin Binding Proteins of classes A, B and C.
Astrid Zervosen; Eric Sauvage; Paulette Charlier; Jean-Marie Frère; André Luxen
Development of new drugs for an old target: the penicillin binding proteins.

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2012: Pablo Power; Paulette Charlier; Georges Dive; Moreno Galleni; Gabriel Gutkind; Raphaël Herman; Frédéric Kerff; Paola Sandra Mercuri; Eric Sauvage
Novel fragments of clavulanate observed in the structure of the class A β-lactamase from Bacillus licheniformis BS3.
The Journal of antimicrobial chemotherapy 2012;67(10):2379-87.
2012: Astrid Zervosen; Eric Sauvage; Ana Amoroso; André Bouillez; Paulette Charlier; Alexandre Herman; Bernard Joris; André Luxen
Synthesis and evaluation of boronic acids as inhibitors of Penicillin Binding Proteins of classes A, B and C.
Bioorganic & medicinal chemistry 2012;20(12):3915-24.
2012: Astrid Zervosen; Eric Sauvage; Paulette Charlier; Jean-Marie Frère; André Luxen
Development of new drugs for an old target: the penicillin binding proteins.
Molecules (Basel, Switzerland) 2012;17(11):12478-505.
2011: Astrid Zervosen; André Bouillez; Paulette Charlier; Jean-Marie Frère; Alexandre Herman; Raphaël Herman; Bernard Joris; Frédéric Kerff; André Luxen; Fabio Prati; Rex F Pratt; Eric Sauvage
Unexpected tricovalent binding mode of boronic acids within the active site of a penicillin-binding protein.
Journal of the American Chemical Society 2011;133(28):10839-48.
2010: Lionel Vercheval; Cédric Bauvois; Alexandre di Paolo; Franck Borel; Jean-Luc Ferrer; Eric Sauvage; Alain Matagne; Jean-Marie Frère; Paulette Charlier; Moreno Galleni; Frédéric Kerff
Three factors that modulate the activity of class D β-lactamases and interfere with the post-translational carboxylation of Lys70.
The Biochemical journal 2010;432(3):495-504.
2010: Liudmila Dzhekieva; Mathieu Rocaboy; Frédéric Kerff; Paulette Charlier; Eric Sauvage; Rex F Pratt
Crystal structure of a complex between the Actinomadura R39 DD-peptidase and a peptidoglycan-mimetic boronate inhibitor: interpretation of a transition state analogue in terms of catalytic mechanism.
Biochemistry 2010;49(30):6411-9.
2010: Frédéric Kerff; Stephanie Petrella; Frédéric Mercier; Eric Sauvage; Raphaël Herman; Anne Pennartz; Astrid Zervosen; André Luxen; Jean-Marie Frère; Bernard Joris; Paulette Charlier
Specific structural features of the N-acetylmuramoyl-L-alanine amidase AmiD from Escherichia coli and mechanistic implications for enzymes of this family.
Journal of molecular biology 2010;397(1):249-59.
2009: Stéphane Baurin; Lionel Vercheval; Fabrice Bouillenne; Claudia Falzone; Alain Brans; Lilian Jacquamet; Jean-Luc Ferrer; Eric Sauvage; Dominique Dehareng; Jean-Marie Frère; Paulette Charlier; Moreno Galleni; Frédéric Kerff
Critical role of tryptophan 154 for the activity and stability of class D beta-lactamases.
Biochemistry 2009;48(47):11252-63.
2009: Eric Sauvage; Astrid Zervosen; Georges Dive; Raphaël Herman; Ana Amoroso; Bernard Joris; Eveline Fonzé; Rex F Pratt; André Luxen; Paulette Charlier; Frédéric Kerff
Structural basis of the inhibition of class A beta-lactamases and penicillin-binding proteins by 6-beta-iodopenicillanate.
Journal of the American Chemical Society 2009;131(42):15262-9.
2008: Frédéric Kerff; Ana Amoroso; Raphaël Herman; Eric Sauvage; Stephanie Petrella; Patrice Filée; Paulette Charlier; Bernard Joris; Akira Tabuchi; Nikolas Nikolaidis; Daniel J Cosgrove
Crystal structure and activity of Bacillus subtilis YoaJ (EXLX1), a bacterial expansin that promotes root colonization.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(44):16876-81.
2008: Eric Sauvage; Ailsa J Powell; Jason Heilemann; Helen R Josephine; Paulette Charlier; Christopher Davies; Rex F Pratt
Crystal structures of complexes of bacterial DD-peptidases with peptidoglycan-mimetic ligands: the substrate specificity puzzle.
Journal of molecular biology 2008;381(2):383-93.
2008: Eric Sauvage; Frédéric Kerff; Mohammed Terrak; Juan A Ayala; Paulette Charlier
The penicillin-binding proteins: structure and role in peptidoglycan biosynthesis.
FEMS microbiology reviews 2008;32(2):234-58.
2008: Waldemar Vollmer; Bernard Joris; Paulette Charlier; Simon Foster
Bacterial peptidoglycan (murein) hydrolases.
FEMS microbiology reviews 2008;32(2):259-86.
2008: Annabelle Lejeune; RH Pain; Paulette Charlier; Jean-Marie Frère; Alain Matagne
TEM-1 beta-lactamase folds in a nonhierarchical manner with transient non-native interactions involving the C-terminal region.
Biochemistry 2008;47(4):1186-93.
2007: Eric Sauvage; Colette Duez; Raphaël Herman; Frédéric Kerff; Stephanie Petrella; John W Anderson; Suara A Adediran; Rex F Pratt; Jean-Marie Frère; Paulette Charlier
Crystal structure of the Bacillus subtilis penicillin-binding protein 4a, and its complex with a peptidoglycan mimetic peptide.
Journal of molecular biology 2007;371(2):528-39.
2006: Helen R Josephine; Paulette Charlier; Christopher Davies; Robert A Nicholas; Rex F Pratt
Reactivity of penicillin-binding proteins with peptidoglycan-mimetic beta-lactams: what's wrong with these enzymes?
Biochemistry 2006;45(51):15873-83.
2006: Eric Sauvage; Eveline Fonzé; Birgit Quinting; Moreno Galleni; Jean-Marie Frère; Paulette Charlier
Crystal structure of the Mycobacterium fortuitum class A beta-lactamase: structural basis for broad substrate specificity.
Antimicrobial agents and chemotherapy 2006;50(7):2516-21.
2005: Eric Sauvage; Raphaël Herman; Stephanie Petrella; Colette Duez; Fabrice Bouillenne; Jean-Marie Frère; Paulette Charlier
Crystal structure of the Actinomadura R39 DD-peptidase reveals new domains in penicillin-binding proteins.
The Journal of biological chemistry 2005;280(35):31249-56.
2003: Frédéric Kerff; Paulette Charlier; Maria-Luigi Colombo; Eric Sauvage; Alain Brans; Jean-Marie Frère; Bernard Joris; Eveline Fonzé
Crystal structure of the sensor domain of the BlaR penicillin receptor from Bacillus licheniformis.
Biochemistry 2003;42(44):12835-43.
2003: Johan Wouters; Eveline Fonzé; Marcel Vermeire; Jean-Marie Frère; Paulette Charlier
Crystal structure of Enterobacter cloacae 908R class C beta-lactamase bound to iodo-acetamido-phenyl boronic acid, a transition-state analogue.
Cellular and molecular life sciences : CMLS 2003;60(8):1764-73.
2003: John W Anderson; Suara A Adediran; Paulette Charlier; Martine Nguyen-Distèche; Jean-Marie Frère; Robert A Nicholas; Rex F Pratt
On the substrate specificity of bacterial DD-peptidases: evidence from two series of peptidoglycan-mimetic peptides.
The Biochemical journal 2003;373(Pt 3):949-55.
2003: Noureddine Rhazi; Paulette Charlier; Dominique Dehareng; Danièle Engher; Marcel Vermeire; Jean-Marie Frère; Martine Nguyen-Distèche; Eveline Fonzé
Catalytic mechanism of the Streptomyces K15 DD-transpeptidase/penicillin-binding protein probed by site-directed mutagenesis and structural analysis.
Biochemistry 2003;42(10):2895-906.
2002: Eric Sauvage; Frédéric Kerff; Eveline Fonzé; Raphaël Herman; Bernard SCHOOT; Jean-Pierre Marquette; Y Taburet; D Prevost; J Dumas; G Leonard; P Stefanic; Jacques Coyette; Paulette Charlier
The 2.4-A crystal structure of the penicillin-resistant penicillin-binding protein PBP5fm from Enterococcus faecium in complex with benzylpenicillin.
Cellular and molecular life sciences : CMLS 2002;59(7):1223-32.
2002: Eveline Fonzé; Marc Vanhove; Georges Dive; Eric Sauvage; Jean-Marie Frère; Paulette Charlier
Crystal structures of the Bacillus licheniformis BS3 class A beta-lactamase and of the acyl-enzyme adduct formed with cefoxitin.
Biochemistry 2002;41(6):1877-85.
2001: Johan Wouters; J Georis; D Engher; Jean Vandenhaute; Jean Dusart; J M Frere; Eric Depiereux; Paulette Charlier
Crystallographic analysis of family 11 endo-beta-1,4-xylanase Xyl1 from Streptomyces sp. S38.
Acta crystallographica. Section D, Biological crystallography 2001;57(Pt 12):1813-9.
2001: Johan Wouters; Paulette Charlier; D Monnaie; Jean-Marie Frère; Eveline Fonzé
Expression, purification, crystallization and preliminary X-ray analysis of the native class C beta-lactamase from Enterobacter cloacae 908R and two mutants.
Acta crystallographica. Section D, Biological crystallography 2001;57(Pt 1):162-4.
1999: Eveline Fonzé; Marcel Vermeire; Martine Nguyen-Distèche; Robert Brasseur; Paulette Charlier
The crystal structure of a penicilloyl-serine transferase of intermediate penicillin sensitivity. The DD-transpeptidase of streptomyces K15.
The Journal of biological chemistry 1999;274(31):21853-60.
1998: Judith A Kelly; Alexandre P Kuzin; Paulette Charlier; Eveline Fonzé
X-ray studies of enzymes that interact with penicillins.
Cellular and molecular life sciences : CMLS 1998;54(4):353-8.
1997: Philippe Ledent; Colette Duez; Marc Vanhove; Annabelle Lejeune; Eveline Fonzé; Paulette Charlier; F Rhazi-Filali; Iris Thamm; Gilliane Guillaume; Bart Samyn; Bart Devreese; Jozef Van Beeumen; Josette Lamotte-Brasseur; Jean-Marie Frère
Unexpected influence of a C-terminal-fused His-tag on the processing of an enzyme and on the kinetic and folding parameters.
FEBS letters 1997;413(2):194-6.
1996: C Damblon; X Raquet; L Y Lian; Josette Lamotte-Brasseur; E Fonze; Paulette Charlier; Gordon Roberts; Jean-Marie Frère
The catalytic mechanism of beta-lactamases: NMR titration of an active-site lysine residue of the TEM-1 enzyme.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(5):1747-52.
1996: Jean-Marie Ghuysen; Paulette Charlier; Jacques Coyette; Colette Duez; Eveline Fonzé; Claudine Fraipont; Colette Goffin; Bernard Joris; Martine Nguyen-Distèche
Penicillin and beyond: evolution, protein fold, multimodular polypeptides, and multiprotein complexes.
Microbial drug resistance (Larchmont, N.Y.) 1996;2(2):163-75.
1995: Eveline Fonzé; Paulette Charlier; Y To'th; M Vermeire; X Raquet; Alain Dubus; Jean-Marie Frère
TEM1 beta-lactamase structure solved by molecular replacement and refined structure of the S235A mutant.
Acta crystallographica. Section D, Biological crystallography 1995;51(Pt 5):682-94.
1994: S Englebert; Paulette Charlier; Eveline Fonzé; Y To'th; M Vermeire; J Van Beeumen; J Grandchamps; K Hoffmann; M Leyh-Bouille; Martine Nguyen-Distèche
Crystallization and X-ray diffraction study of the Streptomyces K15 penicillin-binding DD-transpeptidase.
Journal of molecular biology 1994;241(2):295-7.
1994: M Jamin; C Damblon; A M Bauduin-Misselyn; F Durant; Gordon Roberts; Paulette Charlier; G Llabres; Jean-Marie Frère
Direct n.m.r. evidence for substrate-induced conformational changes in a beta-lactamase.
The Biochemical journal 1994;301 ( Pt 1)():199-203.
1994: Josette Lamotte-Brasseur; J Knox; J A Kelly; Paulette Charlier; Eveline Fonzé; Otto Dideberg; J M Frére
The structures and catalytic mechanisms of active-site serine beta-lactamases.
Biotechnology & genetic engineering reviews 1994;12():189-230.
1993: Paulette Charlier; G Buisson; Otto Dideberg; J Wierenga; W Keck; G Laible; Regine Hakenbeck
Crystallization of a genetically engineered water-soluble primary penicillin target enzyme. The high molecular mass PBP2x of Streptococcus pneumoniae.
Journal of molecular biology 1993;232(3):1007-9.
1991: Josette Lamotte-Brasseur; Georges Dive; Otto Dideberg; Paulette Charlier; Jean-Marie Frère; Jean-Marie Ghuysen
Mechanism of acyl transfer by the class A serine beta-lactamase of Streptomyces albus G.
The Biochemical journal 1991;279 ( Pt 1)():213-21.
1991: S Marcq; A Diaz-Ruano; Paulette Charlier; Otto Dideberg; Catherine Tricot; A Piérard; Victor Stalon
Molecular size and symmetry of Pseudomonas aeruginosa catabolic ornithine carbamoyltransferase. An X-ray crystallography analysis.
Journal of molecular biology 1991;220(1):9-12.
1990: P C Moews; James R Knox; Otto Dideberg; Paulette Charlier; Jean-Marie Frère
Beta-lactamase of Bacillus licheniformis 749/C at 2 A resolution.
Proteins 1990;7(2):156-71.
1988: Jean-Marie Frère; Bernard Joris; Otto Dideberg; Paulette Charlier; J M Ghuysen
Penicillin-recognizing enzymes.
Biochemical Society transactions 1988;16(6):934-8.
1988: Bernard Joris; Jean-Marie Ghuysen; Georges Dive; A Renard; Otto Dideberg; Paulette Charlier; Jean-Marie Frère; J A Kelly; J C Boyington; P C Moews
The active-site-serine penicillin-recognizing enzymes as members of the Streptomyces R61 DD-peptidase family.
The Biochemical journal 1988;250(2):313-24.
1988: Luís C S Ferreira; U Schwarz; W Keck; Paulette Charlier; Otto Dideberg; J M Ghuysen
Properties and crystallization of a genetically engineered, water-soluble derivative of penicillin-binding protein 5 of Escherichia coli K12.
European journal of biochemistry / FEBS 1988;171(1-2):11-6.
1987: Otto Dideberg; Paulette Charlier; J P Wéry; P Dehottay; Jean Dusart; T Erpicum; Jean-Marie Frère; Jean-Marie Ghuysen
The crystal structure of the beta-lactamase of Streptomyces albus G at 0.3 nm resolution.
The Biochemical journal 1987;245(3):911-3.
1986: J A Kelly; Otto Dideberg; Paulette Charlier; J P Wery; M Libert; P C Moews; James R Knox; Colette Duez; Claudine Fraipont; Bernard Joris
On the origin of bacterial resistance to penicillin: comparison of a beta-lactamase and a penicillin target.
Science (New York, N.Y.) 1986;231(4744):1429-31.
1985: Otto Dideberg; M Libert; J M Frère; Paulette Charlier; H Zhao; James R Knox
Crystallization and preliminary X-ray data for the exocellular beta-lactamase of Bacillus licheniformis 749/C.
Journal of molecular biology 1985;181(1):145-6.
1984: Paulette Charlier; Otto Dideberg; J C Jamoulle; Jean-Marie Frère; Jean-Marie Ghuysen; Georges Dive; Josette Lamotte-Brasseur
Active-site-directed inactivators of the Zn2+-containing D-alanyl-D-alanine-cleaving carboxypeptidase of Streptomyces albus G.
The Biochemical journal 1984;219(3):763-72.
1984: Harald Labischinski; P Giesbrecht; E Fischer; G Barnickel; H Bradaczek; J M Frère; C Houssier; Paulette Charlier; Otto Dideberg; J M Ghuysen
Study of the Zn-containing DD-carboxypeptidase of Streptomyces albus G by small-angle X-ray scattering in solution.
European journal of biochemistry / FEBS 1984;138(1):83-7.
1984: Jean-Marie Ghuysen; Jean-Marie Frère; M Leyh-Bouille; Martine Nguyen-Distèche; Jacques Coyette; Jean Dusart; Bernard Joris; Colette Duez; Otto Dideberg; Paulette Charlier
Bacterial wall peptidoglycan, DD-peptidases and beta-lactam antibiotics.
Scandinavian journal of infectious diseases. Supplementum 1984;42():17-37.
1983: Paulette Charlier; Otto Dideberg; Jean-Marie Frère; P C Moews; James R Knox
Crystallographic data for the beta-lactamase from Enterobacter cloacae P99.
Journal of molecular biology 1983;171(2):237-8.
1982: Otto Dideberg; Paulette Charlier; Georges Dive; Bernard Joris; Jean-Marie Frère; Jean-Marie Ghuysen
Structure of a Zn2+-containing D-alanyl-D-alanine-cleaving carboxypeptidase at 2.5 A resolution.
Nature 1982;299(5882):469-70.
1981: G Hamoir; Otto Dideberg; Paulette Charlier
Crystallization and preliminary X-ray data for parvalbumin IIIf of Opsanus tau.
Journal of molecular biology 1981;153(2):487-9.
1980: Otto Dideberg; Paulette Charlier; L Dupont; M Vermeire; Jean-Marie Frere; Jean-Marie Ghuysen
The 4.5 A resolution structure analysis of the exocellular DD-carboxypeptidase of Streptomyces albus G.
FEBS letters 1980;117(1):212-4.