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Susan Charman

Research Profile

Chemicals & Drugs

Living Beings

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Anatomy

Lymphatic System

Disorders

Malaria

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Publications

TOP 3
Xiaofang Wang; Sergio Wittlin; Susan A Charman; Francis C K Chiu; Jacques Chollet; Yuxiang Dong; Kasiram Katneni; Janne Mannila; Julia Morizzi; Eileen Ryan; Josefina Santo Tomas; Christian Scheurer; Christopher Snyder; Jessica Steuten; Jonathan L Vennerstrom
Comparative antimalarial activities and ADME profiles of ozonides (1,2,4-trioxolanes) OZ277, OZ439, and their 1,2-dioxolane, 1,2,4-trioxane, and 1,2,4,5-tetraoxane isosteres.
Cindy J Carroux; Susan A Charman; Kasiram Katneni; Marie Lopez; Janina Moeker; Julia Morizzi; Josephine Motte; Eileen Ryan; David M Shackleford; Laurent F Bornaghi; Sally-Ann Poulsen
Synthesis of acylated glycoconjugates as templates to investigate in vitro biopharmaceutical properties.
Hywel D Williams; Susan A Charman; William N Charman; Colin W Pouton; Ravi M Shanker; Natalie Trevaskis; Christopher J H Porter
Strategies to address low drug solubility in discovery and development.

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All Publications

2013: Xiaofang Wang; Sergio Wittlin; Susan A Charman; Francis C K Chiu; Jacques Chollet; Yuxiang Dong; Kasiram Katneni; Janne Mannila; Julia Morizzi; Eileen Ryan; Josefina Santo Tomas; Christian Scheurer; Christopher Snyder; Jessica Steuten; Jonathan L Vennerstrom
Comparative antimalarial activities and ADME profiles of ozonides (1,2,4-trioxolanes) OZ277, OZ439, and their 1,2-dioxolane, 1,2,4-trioxane, and 1,2,4,5-tetraoxane isosteres.
Journal of medicinal chemistry 2013;56(6):2547-55.
2013: Cindy J Carroux; Susan A Charman; Kasiram Katneni; Marie Lopez; Janina Moeker; Julia Morizzi; Josephine Motte; Eileen Ryan; David M Shackleford; Laurent F Bornaghi; Sally-Ann Poulsen
Synthesis of acylated glycoconjugates as templates to investigate in vitro biopharmaceutical properties.
Bioorganic & medicinal chemistry letters 2013;23(2):455-9.
2013: Hywel D Williams; Susan A Charman; William N Charman; Colin W Pouton; Ravi M Shanker; Natalie Trevaskis; Christopher J H Porter
Strategies to address low drug solubility in discovery and development.
Pharmacological reviews 2013;65(1):315-499.
2012: Diego González Cabrera; Jayan T Joseph; Jolanda Kamber; Kasiram Katneni; Claire Le Manach; Oliver D Montagnat; Aloysius T Nchinda; Eileen Ryan; Christian Scheurer; Leslie J Street; David Waterson; Karen L White; Sergio Wittlin; Michael J Witty; Yassir Younis; K Mohammed Zabiulla; Sridevi Bashyam; Susan A Charman; Frederic Douelle; Tzu-Shean Feng; Kelly Chibale
Structure-activity relationship studies of orally active antimalarial 3,5-substituted 2-aminopyridines.
Journal of medicinal chemistry 2012;55(24):11022-30.
2012: Christel A S Bergström; Susan A Charman; Joseph A Nicolazzo
Computational prediction of CNS drug exposure based on a novel in vivo dataset.
Pharmaceutical research 2012;29(11):3131-42.
2012: Yongyuth Yuthavong; Jirundon Yuvaniyama; Uthai Arwon; Emily Bongard; Susan A Charman; William N Charman; Penchit Chitnumsub; Pascal Fantauzzi; Sumalee Kamchonwongpaisan; Danielle N McLennan; Roonglawan Rattanajak; Bongkoch Tarnchompoo; Supannee Taweechai; Chawanee Thongphanchang; Jarunee Vanichtanankul; Tirayut Vilaivan; Livia Vivas; Karen L White; David Matthews
Malarial dihydrofolate reductase as a paradigm for drug development against a resistance-compromised target.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(42):16823-8.
2012: J Stone Doggett; Isaac Forquer; David J Hinrichs; LORRAINE BRANDO; Kasiram Katneni; Brigitte Meunier; Aaron Nilsen; Claudia Bordón; Jeremy N Burrows; Vernon Bruce Carruthers; Susan A Charman; Tracey Schultz; Keith W Wegmann; Robert H Yolken; Michael K Riscoe
Endochin-like quinolones are highly efficacious against acute and latent experimental toxoplasmosis.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(39):15936-41.
2012: Anne Mannila; Michelle P McIntosh; Julia Morizzi; Thuy Tien Nguyen; Susan A Charman; David M Shackleford
Probing a potential in vivo drug-excipient interaction: temporal effects of a modified β-cyclodextrin on the intravenous pharmacokinetics of a model high-affinity drug ligand.
Journal of pharmaceutical sciences 2012;101(9):3381-9.
2012: Yassir Younis; K Mohammed Zabiulla; Claire Le Manach; Diego González Cabrera; Vicky Avery; Sridevi Bashyam; Ravi Bhamidipati; Susan A Charman; Frederic Douelle; Sandra Duffy; Tzu-Shean Feng; David Hardick; Jayan T Joseph; Kasiram Katneni; Janne Mannila; Julia Morizzi; Aloysius T Nchinda; David M Shackleford; David Waterson; Karen L White; Sergio Wittlin; Michael J Witty; Kelly Chibale
3,5-Diaryl-2-aminopyridines as a novel class of orally active antimalarials demonstrating single dose cure in mice and clinical candidate potential.
Journal of medicinal chemistry 2012;55(7):3479-87.
2012: Sander A A Kooijmans; Muguntha M Mezhiselvam; Julia Morizzi; Susan A Charman; Pierre-Olivier Couraud; Ignacio-Andres Romero; Danielle Senyschyn; Babette Weksler; Joseph A Nicolazzo
The involvement of a Na⁺- and Cl⁻-dependent transporter in the brain uptake of amantadine and rimantadine.
Molecular pharmaceutics 2012;9(4):883-93.
2011: Jose M Coteron; Xiaoyi Deng; Farah El Mazouni; Jorge Esquivias; Santiago B Ferrer; David Floyd; Francisco-Javier Gamo; Elizabeth J Goldsmith; María Belén Jiménez-Díaz; Kasiram Katneni; Sreekanth Kokkonda; Maria Koltun; María Marco; David Matthews; Iñigo Angulo-Barturen; Ian Bathurst; Ravi Bhamidipati; Jeremy N Burrows; Susan A Charman; William N Charman; Pradipsinh K Rathod; David M Shackleford; John White; Karen L White; Margaret A Phillips
Structure-guided lead optimization of triazolopyrimidine-ring substituents identifies potent Plasmodium falciparum dihydroorotate dehydrogenase inhibitors with clinical candidate potential.
Journal of medicinal chemistry 2011;54(15):5540-61.
2011: Susan A Charman; Sarah Arbe-Barnes; Ian C Bathurst; Reto Brun; Michael Campbell; William N Charman; Francis C K Chiu; Jacques Chollet; J Carl Craft; Darren J Creek; Yuxiang Dong; Hugues Matile; Melanie Maurer; Julia Morizzi; Tien Nguyen; Petros Papastogiannidis; Christian Scheurer; David M Shackleford; Kamaraj Sriraghavan; Lukas Stingelin; Yuanqing Tang; Heinrich Urwyler; Xiaofang Wang; Karen L White; Sergio Wittlin; Lin Zhou; Jonathan L Vennerstrom
Synthetic ozonide drug candidate OZ439 offers new hope for a single-dose cure of uncomplicated malaria.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(11):4400-5.
2010: Maria Koltun; Julia Morizzi; Kasiram Katneni; Susan A Charman; David M Shackleford; Michelle P McIntosh
Preclinical comparison of intravenous melphalan pharmacokinetics administered in formulations containing either (SBE)7 m-β-cyclodextrin or a co-solvent system.
Biopharmaceutics & drug disposition 2010;31(8-9):450-4.
2010: Joseph A Nicolazzo; Jessica A Steuten; Susan A Charman; Nerida Taylor; Philip J Davies; Steven Petrou
Brain uptake of diazepam and phenytoin in a genetic animal model of absence epilepsy.
Clinical and experimental pharmacology & physiology 2010;37(5-6):647-9.
2010: Yuanqing Tang; Sergio Wittlin; Susan A Charman; Jacques Chollet; Francis C K Chiu; Julia Morizzi; Lisa M Johnson; Josefina Santo Tomas; Christian Scheurer; Chistopher Snyder; Lin Zhou; Yuxiang Dong; William N Charman; Hugues Matile; Heinrich Urwyler; Arnulf Dorn; Jonathan L Vennerstrom
The comparative antimalarial properties of weak base and neutral synthetic ozonides.
Bioorganic & medicinal chemistry letters 2010;20(2):563-6.
2010: Yuxiang Dong; Sergio Wittlin; Kamaraj Sriraghavan; Jacques Chollet; Susan A Charman; William N Charman; Christian Scheurer; Heinrich Urwyler; Josefina Santo Tomas; Christopher Snyder; Darren J Creek; Julia Morizzi; Maria Koltun; Hugues Matile; Xiaofang Wang; Maniyan Padmanilayam; Yuanqing Tang; Arnulf Dorn; Reto Brun; Jonathan L Vennerstrom
The structure-activity relationship of the antimalarial ozonide arterolane (OZ277).
Journal of medicinal chemistry 2010;53(1):481-91.
2009: Ravi K Bhamidipati; Julia Morizzi; Francis C K Chiu; David M Shackleford; Susan A Charman
Simultaneous determination of OZ277, a synthetic 1,2,4-trioxolane antimalarial, and its polar metabolites in rat plasma using hydrophilic interaction chromatography.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2009;877(27):2989-95.
2009: Xiaofang Wang; Darren J Creek; Charles E Schiaffo; Yuxiang Dong; Jacques Chollet; Christian Scheurer; Sergio Wittlin; Susan A Charman; Patrick H Dussault; James K Wood; Jonathan L Vennerstrom
Spiroadamantyl 1,2,4-trioxolane, 1,2,4-trioxane, and 1,2,4-trioxepane pairs: relationship between peroxide bond iron(II) reactivity, heme alkylation efficiency, and antimalarial activity.
Bioorganic & medicinal chemistry letters 2009;19(16):4542-5.
2009: Darren J Creek; Eileen Ryan; William N Charman; Francis C K Chiu; Richard J Prankerd; Jonathan L Vennerstrom; Susan A Charman
Stability of peroxide antimalarials in the presence of human hemoglobin.
Antimicrobial agents and chemotherapy 2009;53(8):3496-500.
2008: Kasiram Katneni; Susan A Charman; Christopher J H Porter
An evaluation of the relative roles of the unstirred water layer and receptor sink in limiting the in-vitro intestinal permeability of drug compounds of varying lipophilicity.
The Journal of pharmacy and pharmacology 2008;60(10):1311-9.
2008: Darren J Creek; William N Charman; Francis C K Chiu; Richard J Prankerd; Yuxiang Dong; Jonathan L Vennerstrom; Susan A Charman
Relationship between antimalarial activity and heme alkylation for spiro- and dispiro-1,2,4-trioxolane antimalarials.
Antimicrobial agents and chemotherapy 2008;52(4):1291-6.
2008: Lin Zhou; André Alker; Armin Ruf; Xiaofang Wang; Francis C K Chiu; Julia Morizzi; Susan A Charman; William N Charman; Christian Scheurer; Sergio Wittlin; Yuxiang Dong; Daniel Hunziker; Jonathan L Vennerstrom
Characterization of the two major CYP450 metabolites of ozonide (1,2,4-trioxolane) OZ277.
Bioorganic & medicinal chemistry letters 2008;18(5):1555-8.
2008: Joseph A Nicolazzo; Tien T Nguyen; Kasiram Katneni; Jessica A Steuten; Gregg Smith; Bevyn Jarrott; Jennifer K Callaway; Susan A Charman
Pharmacokinetics and brain uptake of AM-36, a novel neuroprotective agent, following intravenous administration to rats.
The Journal of pharmacy and pharmacology 2008;60(2):171-8.
2008: Kasiram Katneni; Susan A Charman; Christopher J H Porter
Use of plasma proteins as solubilizing agents in in vitro permeability experiments: correction for unbound drug concentration using the reciprocal permeability approach.
Journal of pharmaceutical sciences 2008;97(1):209-24.
2007: Jagannath Kota; Krishna K Machavaram; Danielle N McLennan; Glenn A Edwards; Christopher J H Porter; Susan A Charman
Lymphatic absorption of subcutaneously administered proteins: influence of different injection sites on the absorption of darbepoetin alfa using a sheep model.
Drug metabolism and disposition: the biological fate of chemicals 2007;35(12):2211-7.
2007: Xiaofang Wang; Yuxiang Dong; Sergio Wittlin; Darren J Creek; Jacques Chollet; Susan A Charman; Josefina Santo Tomas; Christian Scheurer; Christopher Snyder; Jonathan L Vennerstrom
Spiro- and dispiro-1,2-dioxolanes: contribution of iron(II)-mediated one-electron vs two-electron reduction to the activity of antimalarial peroxides.
Journal of medicinal chemistry 2007;50(23):5840-7.
2007: Darren J Creek; William N Charman; Francis C K Chiu; Richard J Prankerd; Kevin J McCullough; Yuxiang Dong; Jonathan L Vennerstrom; Susan A Charman
Iron-mediated degradation kinetics of substituted dispiro-1,2,4-trioxolane antimalarials.
Journal of pharmaceutical sciences 2007;96(11):2945-56.
2007: Yuxiang Dong; Darren J Creek; Jacques Chollet; Hugues Matile; Susan A Charman; Sergio Wittlin; James K Wood; Jonathan L Vennerstrom
Comparative antimalarial activities of six pairs of 1,2,4,5-tetraoxanes (peroxide dimers) and 1,2,4,5,7,8-hexaoxonanes (peroxide trimers).
Antimicrobial agents and chemotherapy 2007;51(8):3033-5.
2007: Yuanqing Tang; Yuxiang Dong; Sergio Wittlin; Susan A Charman; Jacques Chollet; Francis C K Chiu; William N Charman; Hugues Matile; Heinrich Urwyler; Arnulf Dorn; Saroj Bajpai; Xiaofang Wang; Maniyan Padmanilayam; Jean M Karle; Reto Brun; Jonathan L Vennerstrom
Weak base dispiro-1,2,4-trioxolanes: potent antimalarial ozonides.
Bioorganic & medicinal chemistry letters 2007;17(5):1260-5.
2007: Kasiram Katneni; Susan A Charman; Christopher J H Porter
Impact of cremophor-EL and polysorbate-80 on digoxin permeability across rat jejunum: delineation of thermodynamic and transporter related events using the reciprocal permeability approach.
Journal of pharmaceutical sciences 2007;96(2):280-93.
2006: Maniyan Padmanilayam; Bernard Scorneaux; Yuxiang Dong; Jacques Chollet; Hugues Matile; Susan A Charman; Darren J Creek; William N Charman; Josefina Santo Tomas; Christian Scheurer; Sergio Wittlin; Reto Brun; Jonathan L Vennerstrom
Antimalarial activity of N-alkyl amine, carboxamide, sulfonamide, and urea derivatives of a dispiro-1,2,4-trioxolane piperidine.
Bioorganic & medicinal chemistry letters 2006;16(21):5542-5.
2006: Kasiram Katneni; Susan A Charman; Christopher J H Porter
Permeability assessment of poorly water-soluble compounds under solubilizing conditions: the reciprocal permeability approach.
Journal of pharmaceutical sciences 2006;95(10):2170-85.
2006: Yuxiang Dong; Yuanqing Tang; Jacques Chollet; Hugues Matile; Sergio Wittlin; Susan A Charman; William N Charman; Josefina Santo Tomas; Christian Scheurer; Christopher Snyder; Bernard Scorneaux; Saroj Bajpai; Scott A Alexander; Xiaofang Wang; Maniyan Padmanilayam; Srinivasa R Cheruku; Reto Brun; Jonathan L Vennerstrom
Effect of functional group polarity on the antimalarial activity of spiro and dispiro-1,2,4-trioxolanes.
Bioorganic & medicinal chemistry 2006;14(18):6368-82.
2006: Danielle N McLennan; Christopher J H Porter; Glenn A Edwards; Anne C Heatherington; Steven W Martin; Susan A Charman
The absorption of darbepoetin alfa occurs predominantly via the lymphatics following subcutaneous administration to sheep.
Pharmaceutical research 2006;23(9):2060-6.
2006: Sonja Maerki; Reto Brun; Susan A Charman; Arnulf Dorn; Hugues Matile; Sergio Wittlin
In vitro assessment of the pharmacodynamic properties and the partitioning of OZ277/RBx-11160 in cultures of Plasmodium falciparum.
The Journal of antimicrobial chemotherapy 2006;58(1):52-8.
2006: Christine S Perry; Susan A Charman; Richard J Prankerd; Francis C K Chiu; Yuxiang Dong; Jonathan L Vennerstrom; William N Charman
Chemical kinetics and aqueous degradation pathways of a new class of synthetic ozonide antimalarials.
Journal of pharmaceutical sciences 2006;95(4):737-47.
2006: Joseph A Nicolazzo; Susan A Charman; William N Charman
Methods to assess drug permeability across the blood-brain barrier.
The Journal of pharmacy and pharmacology 2006;58(3):281-93.
2006: Susan A Charman; Christine S Perry; Francis C K Chiu; Kylie A McIntosh; Richard J Prankerd; William N Charman
Alteration of the intravenous pharmacokinetics of a synthetic ozonide antimalarial in the presence of a modified cyclodextrin.
Journal of pharmaceutical sciences 2006;95(2):256-67.
2006: Christine S Perry; Susan A Charman; Richard J Prankerd; Francis C K Chiu; Martin Scanlon; David Chalmers; William N Charman
The binding interaction of synthetic ozonide antimalarials with natural and modified beta-cyclodextrins.
Journal of pharmaceutical sciences 2006;95(1):146-58.
2005: Darren J Creek; Francis C K Chiu; Richard J Prankerd; Susan A Charman; William N Charman
Kinetics of iron-mediated artemisinin degradation: effect of solvent composition and iron salt.
Journal of pharmaceutical sciences 2005;94(8):1820-9.
2005: Yuxiang Dong; Jacques Chollet; Hugues Matile; Susan A Charman; Francis C K Chiu; William N Charman; Bernard Scorneaux; Heinrich Urwyler; Josefina Santo Tomas; Christian Scheurer; Christopher Snyder; Arnulf Dorn; Xiaofang Wang; Jean M Karle; Yuanqing Tang; Sergio Wittlin; Reto Brun; Jonathan L Vennerstrom
Spiro and dispiro-1,2,4-trioxolanes as antimalarial peroxides: charting a workable structure-activity relationship using simple prototypes.
Journal of medicinal chemistry 2005;48(15):4953-61.
2005: Danielle N McLennan; Christopher J H Porter; Glenn A Edwards; Steven W Martin; Anne C Heatherington; Susan A Charman
Lymphatic absorption is the primary contributor to the systemic availability of epoetin Alfa following subcutaneous administration to sheep.
The Journal of pharmacology and experimental therapeutics 2005;313(1):345-51.
2004: Jonathan L Vennerstrom; Sarah Arbe-Barnes; Reto Brun; Susan A Charman; Francis C K Chiu; Jacques Chollet; Yuxiang Dong; Arnulf Dorn; Daniel Hunziker; Hugues Matile; Kylie McIntosh; Maniyan Padmanilayam; Josefina Santo Tomas; Christian Scheurer; Bernard Scorneaux; Yuanqing Tang; Heinrich Urwyler; Sergio Wittlin; William N Charman
Identification of an antimalarial synthetic trioxolane drug development candidate.
Nature 2004;430(7002):900-4.
2004: Alicia M Segrave; Donald E Mager; Susan A Charman; Glenn A Edwards; Christopher J H Porter
Pharmacokinetics of recombinant human leukemia inhibitory factor in sheep.
The Journal of pharmacology and experimental therapeutics 2004;309(3):1085-92.
2003: Danielle N McLennan; Christopher J H Porter; Glenn A Edwards; Maria Brumm; Steven W Martin; Susan A Charman
Pharmacokinetic model to describe the lymphatic absorption of r-metHu-leptin after subcutaneous injection to sheep.
Pharmaceutical research 2003;20(8):1156-62.
2002: D F Vine; Susan A Charman; Peter R Gibson; A J Sinclair; Christopher J H Porter
Effect of dietary fatty acids on the intestinal permeability of marker drug compounds in excised rat jejunum.
The Journal of pharmacy and pharmacology 2002;54(6):809-19.
2001: Susan A Charman; Danielle N McLennan; Glenn A Edwards; Christopher J H Porter
Lymphatic absorption is a significant contributor to the subcutaneous bioavailability of insulin in a sheep model.
Pharmaceutical research 2001;18(11):1620-6.
2001: Christopher J H Porter; Glenn A Edwards; Susan A Charman
Lymphatic transport of proteins after s.c. injection: implications of animal model selection.
Advanced drug delivery reviews 2001;50(1-2):157-71.
2000: Christopher J H Porter; Susan A Charman
Lymphatic transport of proteins after subcutaneous administration.
Journal of pharmaceutical sciences 2000;89(3):297-310.
2000: Susan A Charman; A M Segrave; Glenn A Edwards; Christopher J H Porter
Systemic availability and lymphatic transport of human growth hormone administered by subcutaneous injection.
Journal of pharmaceutical sciences 2000;89(2):168-77.
1998: Kylie A McIntosh; Susan A Charman; L A Borgen; William N Charman
Analytical methods and stability assessment of liquid yeast derived sucrase.
Journal of pharmaceutical and biomedical analysis 1998;17(6-7):1037-45.
1998: Kylie A McIntosh; William N Charman; Susan A Charman
The application of capillary electrophoresis for monitoring effects of excipients on protein conformation.
Journal of pharmaceutical and biomedical analysis 1998;16(6):1097-105.
1996: M M Doherty; P J Hughes; Susan A Charman; K V Brock; N V Korszniak; William N Charman
Biphasic drug absorption from the epidural space of the dog may limit the utility of a slow release medium molecular weight hyaluronic acid-lidocaine ionic complex formulation.
Anesthesia and analgesia 1996;83(6):1244-50.