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Israel Charo

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Nicholas H Varvel; Christian Liebig; Richard M Ransohoff; Dietmar R Thal; Adriano Aguzzi; Frank Baumann; Andrea Bosch; Bianca Brawek; Israel F Charo; Olga Garaschuk; Stefan A Grathwohl; Frank L Heppner; Mathias Jucker
Microglial repopulation model reveals a robust homeostatic process for replacing CNS myeloid cells.
Timothy J Sullivan; Chia-Lin Tsou; Solomon Ungashe; Yu Wang; Zheng Wei; Bin N Zhao; Dan Johnson; Antoni Krasinski; Shichang Miao; Zhenhua Miao; Andrew Pennell; Thomas J Schall; Lisa Seitz; Trageen Baumgart; Pirow Bekker; Rob Berahovich; Landin Boring; Israel F Charo; Daniel J Dairaghi; Linda S Ertl; Juan C Jaen
Characterization of CCX140-B, an orally bioavailable antagonist of the CCR2 chemokine receptor, for the treatment of type 2 diabetes and associated complications.
Kanako L Lewis; Kang Liu; Miriam Merad; Dennis Ng; Milena Bogunovic; Michele L Caton; Israel F Charo; Jennifer L Gommerman; Lucja T Grajkowska; Melanie Greter; Ivaylo I Ivanov; Steffen Jung; Apostolos Klinakis; Boris Reizis
Notch2 receptor signaling controls functional differentiation of dendritic cells in the spleen and intestine.

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2012: Nicholas H Varvel; Christian Liebig; Richard M Ransohoff; Dietmar R Thal; Adriano Aguzzi; Frank Baumann; Andrea Bosch; Bianca Brawek; Israel F Charo; Olga Garaschuk; Stefan A Grathwohl; Frank L Heppner; Mathias Jucker
Microglial repopulation model reveals a robust homeostatic process for replacing CNS myeloid cells.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(44):18150-5.
2012: Timothy J Sullivan; Chia-Lin Tsou; Solomon Ungashe; Yu Wang; Zheng Wei; Bin N Zhao; Dan Johnson; Antoni Krasinski; Shichang Miao; Zhenhua Miao; Andrew Pennell; Thomas J Schall; Lisa Seitz; Trageen Baumgart; Pirow Bekker; Rob Berahovich; Landin Boring; Israel F Charo; Daniel J Dairaghi; Linda S Ertl; Juan C Jaen
Characterization of CCX140-B, an orally bioavailable antagonist of the CCR2 chemokine receptor, for the treatment of type 2 diabetes and associated complications.
The Journal of pharmacology and experimental therapeutics 2012;():.
2011: Kanako L Lewis; Kang Liu; Miriam Merad; Dennis Ng; Milena Bogunovic; Michele L Caton; Israel F Charo; Jennifer L Gommerman; Lucja T Grajkowska; Melanie Greter; Ivaylo I Ivanov; Steffen Jung; Apostolos Klinakis; Boris Reizis
Notch2 receptor signaling controls functional differentiation of dendritic cells in the spleen and intestine.
Immunity 2011;35(5):780-91.
2011: Israel F Charo; Rebecca Taub
Anti-inflammatory therapeutics for the treatment of atherosclerosis.
Nature reviews. Drug discovery 2011;10(5):365-76.
2011: Koh-Hei Sonoda; Takeru Yoshimura; Kensuke Egashira; Israel F Charo; Tatsuro Ishibashi
Neutrophil-dominant experimental autoimmune uveitis in CC-chemokine receptor 2 knockout mice.
Acta ophthalmologica 2011;89(2):e180-8.
2011: Sabina A Islam; Daniel S Chang; Richard A Colvin; Mike H Byrne; Michelle L McCully; Bernhard Moser; Sergio A Lira; Israel F Charo; Andrew D Luster
Mouse CCL8, a CCR8 agonist, promotes atopic dermatitis by recruiting IL-5+ T(H)2 cells.
Nature immunology 2011;12(2):167-77.
2011: Haiyan Lu; Danping Huang; Noah Saederup; Israel F Charo; Richard M Ransohoff; Lan Zhou
Macrophages recruited via CCR2 produce insulin-like growth factor-1 to repair acute skeletal muscle injury.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2011;25(1):358-69.
2010: Wei Yan; Yue Si; Sarah Slaymaker; Jiachen Li; Huili Zheng; David L Young; Ara Aslanian; Laura Saunders; Eric Verdin; Israel F Charo
Zmynd15 encodes a histone deacetylase-dependent transcriptional repressor essential for spermiogenesis and male fertility.
The Journal of biological chemistry 2010;285(41):31418-26.
2010: Alan Daugherty; Debra L Rateri; Israel F Charo; A Phillip Owens; Deborah A Howatt; Lisa A Cassis
Angiotensin II infusion promotes ascending aortic aneurysms: attenuation by CCR2 deficiency in apoE-/- mice.
Clinical science (London, England : 1979) 2010;118(11):681-9.
2010: Yue Si; Chia-Lin Tsou; Kelsey Croft; Israel F Charo
CCR2 mediates hematopoietic stem and progenitor cell trafficking to sites of inflammation in mice.
The Journal of clinical investigation 2010;120(4):1192-203.
2010: Noah Saederup; Astrid E Cardona; Kelsey Croft; Makiko Mizutani; Anne C Cotleur; Chia-Lin Tsou; Richard M Ransohoff; Israel F Charo
Selective chemokine receptor usage by central nervous system myeloid cells in CCR2-red fluorescent protein knock-in mice.
PloS one 2010;5(10):e13693.
2008: Andrea P Martin; Sara Rankin; Simon Pitchford; Israel F Charo; Glaucia C Furtado; sergio lira
Increased expression of CCL2 in insulin-producing cells of transgenic mice promotes mobilization of myeloid cells from the bone marrow, marked insulitis, and diabetes.
Diabetes 2008;57(11):3025-33.
2008: Ting Jia; Natalya V Serbina; Katharina Brandl; Maggie X Zhong; Ingrid M Leiner; Israel F Charo; Eric G Pamer
Additive roles for MCP-1 and MCP-3 in CCR2-mediated recruitment of inflammatory monocytes during Listeria monocytogenes infection.
Journal of immunology (Baltimore, Md. : 1950) 2008;180(10):6846-53.
2008: Noah Saederup; Liana Chan; sergio lira; Israel F Charo
Fractalkine deficiency markedly reduces macrophage accumulation and atherosclerotic lesion formation in CCR2-/- mice: evidence for independent chemokine functions in atherogenesis.
Circulation 2008;117(13):1642-8.
2008: Jeffrey D Alexis; Robert T Pyo; Igor Chereshnev; Jonathan Katz; Barrett J Rollins; Israel F Charo; Mark B Taubman
Inhibition of MCP-1/CCR2 signaling does not inhibit intimal proliferation in a mouse aortic transplant model.
Journal of vascular research 2008;45(6):538-46.
2007: Israel F Charo
Macrophage polarization and insulin resistance: PPARgamma in control.
Cell metabolism 2007;6(2):96-8.
2007: Chia-Lin Tsou; Wendy Peters; Yue Si; Sarah Slaymaker; Ara M Aslanian; Stuart P Weisberg; Matthias Mack; Israel F Charo
Critical roles for CCR2 and MCP-3 in monocyte mobilization from bone marrow and recruitment to inflammatory sites.
The Journal of clinical investigation 2007;117(4):902-9.
2006: Nathan B Sautter; Elizabeth H Shick; Richard M Ransohoff; Israel F Charo; Keiko Hirose
CC chemokine receptor 2 is protective against noise-induced hair cell death: studies in CX3CR1(+/GFP) mice.
Journal of the Association for Research in Otolaryngology : JARO 2006;7(4):361-72.
2006: Davide Ragozzino; Silvia Di Angelantonio; Flavia Trettel; Cristina Bertollini; Laura Maggi; Cornelius Gross; Israel F Charo; Cristina Limatola; Fabrizio Eusebi
Chemokine fractalkine/CX3CL1 negatively modulates active glutamatergic synapses in rat hippocampal neurons.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2006;26(41):10488-98.
2006: Ara M Aslanian; Israel F Charo
Targeted disruption of the scavenger receptor and chemokine CXCL16 accelerates atherosclerosis.
Circulation 2006;114(6):583-90.
2006: Simone R Green; Ki Hoon Han; Yiming Chen; Felicidad Almazan; Israel F Charo; Yury I Miller; Oswald Quehenberger
The CC chemokine MCP-1 stimulates surface expression of CX3CR1 and enhances the adhesion of monocytes to fractalkine/CX3CL1 via p38 MAPK.
Journal of immunology (Baltimore, Md. : 1950) 2006;176(12):7412-20.
2006: Tahir Ali; Julia Humphries; Kevin G Burnand; Barbara Sawyer; Christina Bursill; Keith Channon; David Greaves; Barrett J Rollins; Israel F Charo; Alberto Smith
Monocyte recruitment in venous thrombus resolution.
Journal of vascular surgery 2006;43(3):601-8.
2006: Israel F Charo; Richard M Ransohoff
The many roles of chemokines and chemokine receptors in inflammation.
The New England journal of medicine 2006;354(6):610-21.
2006: Toru Oshima; Koh-Hei Sonoda; Chikako Tsutsumi-Miyahara; Hong Qiao; Toshio Hisatomi; Shintaro Nakao; Shinjiro Hamano; Kensuke Egashira; Israel F Charo; Tatsuro Ishibashi
Analysis of corneal inflammation induced by cauterisation in CCR2 and MCP-1 knockout mice.
The British journal of ophthalmology 2006;90(2):218-22.
2006: Stuart P Weisberg; Deborah Hunter; Reid Huber; Jacob Lemieux; Sarah Slaymaker; Kris Vaddi; Israel F Charo; Rudolph L Leibel; Anthony W Ferrante
CCR2 modulates inflammatory and metabolic effects of high-fat feeding.
The Journal of clinical investigation 2006;116(1):115-24.
2005: Niels R Veillard; Sabine Steffens; Graziano Pelli; B Lu; Brenda R Kwak; Craig Gerard; Israel F Charo; François Mach
Differential influence of chemokine receptors CCR2 and CXCR3 in development of atherosclerosis in vivo.
Circulation 2005;112(6):870-8.
2005: Deren Huang; Jerome R Wujek; Grahame J Kidd; Toby T He; Astrid E Cardona; Margaret E Sasse; Erica J Stein; Jacqueline Kish; Marie Tani; Israel F Charo; Amanda E Proudfoot; Barrett J Rollins; Tracy Handel; Richard M Ransohoff
Chronic expression of monocyte chemoattractant protein-1 in the central nervous system causes delayed encephalopathy and impaired microglial function in mice.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2005;19(7):761-72.
2005: Ara M Aslanian; Harold A Chapman; Israel F Charo
Transient role for CD1d-restricted natural killer T cells in the formation of atherosclerotic lesions.
Arteriosclerosis, thrombosis, and vascular biology 2005;25(3):628-32.
2004: Chunfeng Qu; Emmerson W Edwards; Frank Tacke; Véronique Angeli; Jaime Llodrá; Guzman Sanchez-Schmitz; Alexandre Garin; Nasreen Haque; Wendy Peters; Nico van Rooijen; Carmen Sanchez-Torres; Jonathan Bromberg; Israel F Charo; Steffen Jung; sergio lira; Gwendalyn J Randolph
Role of CCR8 and other chemokine pathways in the migration of monocyte-derived dendritic cells to lymph nodes.
The Journal of experimental medicine 2004;200(10):1231-41.
2004: Minako Ishibashi; Kensuke Egashira; Qingwei Zhao; Ken-ichi Hiasa; Kisho Ohtani; Yoshiko Ihara; Israel F Charo; Shinobu Kura; Teruhisa Tsuzuki; Akira Takeshita; Kenji Sunagawa
Bone marrow-derived monocyte chemoattractant protein-1 receptor CCR2 is critical in angiotensin II-induced acceleration of atherosclerosis and aneurysm formation in hypercholesterolemic mice.
Arteriosclerosis, thrombosis, and vascular biology 2004;24(11):e174-8.
2004: Israel F Charo; Mark B Taubman
Chemokines in the pathogenesis of vascular disease.
Circulation research 2004;95(9):858-66.
2004: Gale Tang; David N Charo; Rong Wang; Israel F Charo; Louis M Messina
CCR2-/- knockout mice revascularize normally in response to severe hindlimb ischemia.
Journal of vascular surgery 2004;40(4):786-95.
2004: Bo-Chin Chiu; Christine M Freeman; Valerie R Stolberg; Jerry S Hu; Kyriaki Zeibecoglou; Bao Lu; Craig Gerard; Israel F Charo; sergio lira; Stephen W Chensue
Impaired lung dendritic cell activation in CCR2 knockout mice.
The American journal of pathology 2004;165(4):1199-209.
2004: Chikako Tsutsumi-Miyahara; Koh-Hei Sonoda; Kensuke Egashira; Minako Ishibashi; Hong Qiao; Toru Oshima; Toshinori Murata; M Miyazaki; Israel F Charo; Shinjiro Hamano; Tatsuro Ishibashi
The relative contributions of each subset of ocular infiltrated cells in experimental choroidal neovascularisation.
The British journal of ophthalmology 2004;88(9):1217-22.
2004: Wendy Peters; Jason G Cyster; Matthias Mack; Detlef Schlöndorff; Andrea J Wolf; Joel D Ernst; Israel F Charo
CCR2-dependent trafficking of F4/80dim macrophages and CD11cdim/intermediate dendritic cells is crucial for T cell recruitment to lungs infected with Mycobacterium tuberculosis.
Journal of immunology (Baltimore, Md. : 1950) 2004;172(12):7647-53.
2004: Alison D Schecter; Adriane B Berman; Lin Yi; Harry Ma; Christine M Daly; Kenzo Soejima; Barrett J Rollins; Israel F Charo; Mark B Taubman
MCP-1-dependent signaling in CCR2(-/-) aortic smooth muscle cells.
Journal of leukocyte biology 2004;75(6):1079-85.
2004: Minako Ishibashi; Ken-ichi Hiasa; Qingwei Zhao; Shujiro Inoue; Kisho Ohtani; Shiro Kitamoto; Miyuki Tsuchihashi; Takeshi Sugaya; Israel F Charo; Shinobu Kura; Teruhisa Tsuzuki; Tatsuro Ishibashi; Akira Takeshita; Kensuke Egashira
Critical role of monocyte chemoattractant protein-1 receptor CCR2 on monocytes in hypertension-induced vascular inflammation and remodeling.
Circulation research 2004;94(9):1203-10.
2004: Miriam Merad; Petra Hoffmann; Erik Ranheim; Sarah Slaymaker; Markus G Manz; sergio lira; Israel F Charo; Donald N Cook; Irving L Weissman; Samuel Strober; Edgar G Engleman
Depletion of host Langerhans cells before transplantation of donor alloreactive T cells prevents skin graft-versus-host disease.
Nature medicine 2004;10(5):510-7.
2004: Angela Panoskaltsis-Mortari; John R Hermanson; Elizabeth Taras; O Douglas Wangensteen; Israel F Charo; Barrett J Rollins; Bruce R Blazar
Post-BMT lung injury occurs independently of the expression of CCL2 or its receptor, CCR2, on host cells.
American journal of physiology. Lung cellular and molecular physiology 2004;286(2):L284-92.
2004: Laura L Koth; Madeleine W Rodriguez; Xin Liu Bernstein; Salina Chan; Xiaozhu Huang; Israel F Charo; Barrett J Rollins; David J Erle
Aspergillus antigen induces robust Th2 cytokine production, inflammation, airway hyperreactivity and fibrosis in the absence of MCP-1 or CCR2.
Respiratory research 2004;5():12.
2003: Mehrnaz Gharaee-Kermani; Robert E McCullumsmith; Israel F Charo; Steven Kunkel; Sem H Phan
CC-chemokine receptor 2 required for bleomycin-induced pulmonary fibrosis.
Cytokine 2003;24(6):266-76.
2003: Chikako Tsutsumi; Koh-Hei Sonoda; Kensuke Egashira; Hong Qiao; Toshio Hisatomi; Shintaro Nakao; Minako Ishibashi; Israel F Charo; Taiji Sakamoto; Toshinori Murata; Tatsuro Ishibashi
The critical role of ocular-infiltrating macrophages in the development of choroidal neovascularization.
Journal of leukocyte biology 2003;74(1):25-32.
2003: Israel F Charo; Wendy Peters
Chemokine receptor 2 (CCR2) in atherosclerosis, infectious diseases, and regulation of T-cell polarization.
Microcirculation (New York, N.Y. : 1994) 2003;10(3-4):259-64.
2003: Philippe Lesnik; Christopher A Haskell; Israel F Charo
Decreased atherosclerosis in CX3CR1-/- mice reveals a role for fractalkine in atherogenesis.
The Journal of clinical investigation 2003;111(3):333-40.
2003: Olga Stein; Yedida Dabach; Mazal Ben-Naim; Gideon Halperin; Israel F Charo; Yechezkiel Stein
In CCR2-/- mice monocyte recruitment and egress of LDL cholesterol in vivo is impaired.
Biochemical and biophysical research communications 2003;300(2):477-81.
2002: DeRen Huang; Marie Tani; Jintang Wang; Yulong Han; Toby T He; Jennifer Weaver; Israel F Charo; Vincent K Tuohy; Barrett J Rollins; Richard M Ransohoff
Pertussis toxin-induced reversible encephalopathy dependent on monocyte chemoattractant protein-1 overexpression in mice.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2002;22(24):10633-42.
2002: Miriam Merad; Markus G Manz; Holger Karsunky; Amy J Wagers; Wendy Peters; Israel F Charo; Irving L Weissman; Jason G Cyster; Edgar G Engleman
Langerhans cells renew in the skin throughout life under steady-state conditions.
Nature immunology 2002;3(12):1135-41.
2002: Manhong Ma; Tao Wei; Landin Boring; Israel F Charo; Richard M Ransohoff; Lyn B Jakeman
Monocyte recruitment and myelin removal are delayed following spinal cord injury in mice with CCR2 chemokine receptor deletion.
Journal of neuroscience research 2002;68(6):691-702.
2002: Kensuke Egashira; Qingwei Zhao; Chu Kataoka; Kisho Ohtani; Makoto Usui; Israel F Charo; Ken-Ichi Nishida; Shujiro Inoue; Makoto Katoh; Toshihiro Ichiki; Akira Takeshita
Importance of monocyte chemoattractant protein-1 pathway in neointimal hyperplasia after periarterial injury in mice and monkeys.
Circulation research 2002;90(11):1167-72.
2002: Laurie A Tylaska; Landin Boring; W Weng; Robert J Aiello; Israel F Charo; Barrett J Rollins; Ronald P Gladue
Ccr2 regulates the level of MCP-1/CCL2 in vitro and at inflammatory sites and controls T cell activation in response to alloantigen.
Cytokine 2002;18(4):184-90.
2002: Merce Roque; William J H Kim; Michaela Gazdoin; Alia Malik; Ernane D Reis; John T Fallon; Juan J Badimon; Israel F Charo; Mark B Taubman
CCR2 deficiency decreases intimal hyperplasia after arterial injury.
Arteriosclerosis, thrombosis, and vascular biology 2002;22(4):554-9.
2002: Oliver T Keppler; Frank Welte; Tuan A Ngo; Peggy S Chin; Kathryn S Patton; Chia-Lin Tsou; Nancy W Abbey; Mark E Sharkey; Robert M Grant; Yun You; John D Scarborough; Wilfried Ellmeier; Dan R Littman; Mario Stevenson; Israel F Charo; Brian G Herndier; Roberto F Speck; Mark A Goldsmith
Progress toward a human CD4/CCR5 transgenic rat model for de novo infection by human immunodeficiency virus type 1.
The Journal of experimental medicine 2002;195(6):719-36.
2002: Zhou Zhu; Bing Ma; Tao Zheng; Robert J Homer; Chun Geun Lee; Israel F Charo; Paul Noble; Jack A Elias
IL-13-induced chemokine responses in the lung: role of CCR2 in the pathogenesis of IL-13-induced inflammation and remodeling.
Journal of immunology (Baltimore, Md. : 1950) 2002;168(6):2953-62.
2001: Chia-Lin Tsou; Christopher A Haskell; Israel F Charo
Tumor necrosis factor-alpha-converting enzyme mediates the inducible cleavage of fractalkine.
The Journal of biological chemistry 2001;276(48):44622-6.
2001: Christopher A Haskell; Wayne W Hancock; David J Salant; Wei Gao; V Csizmadia; Wendy Peters; KL Faia; O Fituri; J B Rottman; Israel F Charo
Targeted deletion of CX(3)CR1 reveals a role for fractalkine in cardiac allograft rejection.
The Journal of clinical investigation 2001;108(5):679-88.
2001: Wendy Peters; Holly M Scott; H F Chambers; J L Flynn; Israel F Charo; Joel D Ernst
Chemokine receptor 2 serves an early and essential role in resistance to Mycobacterium tuberculosis.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(14):7958-63.
2001: Penelope M Drake; M D Gunn; Israel F Charo; Chia-Lin Tsou; Y Zhou; L Huang; Susan J Fisher
Human placental cytotrophoblasts attract monocytes and CD56(bright) natural killer cells via the actions of monocyte inflammatory protein 1alpha.
The Journal of experimental medicine 2001;193(10):1199-212.
2000: Wendy Peters; M Dupuis; Israel F Charo
A mechanism for the impaired IFN-gamma production in C-C chemokine receptor 2 (CCR2) knockout mice: role of CCR2 in linking the innate and adaptive immune responses.
Journal of immunology (Baltimore, Md. : 1950) 2000;165(12):7072-7.
2000: Christopher A Haskell; M D Cleary; Israel F Charo
Unique role of the chemokine domain of fractalkine in cell capture. Kinetics of receptor dissociation correlate with cell adhesion.
The Journal of biological chemistry 2000;275(44):34183-9.
2000: Kate Blease; Borna Mehrad; Theodore J Standiford; Nicholas W Lukacs; J Gosling; Landin Boring; Israel F Charo; Steven Kunkel; Cory M Hogaboam
Enhanced pulmonary allergic responses to Aspergillus in CCR2-/- mice.
Journal of immunology (Baltimore, Md. : 1950) 2000;165(5):2603-11.
2000: Cory M Hogaboam; Cynthia L Bone-Larson; ML Steinhauser; Akihiro Matsukawa; J Gosling; Landin Boring; Israel F Charo; Kenneth J Simpson; Nicholas W Lukacs; Steven Kunkel
Exaggerated hepatic injury due to acetaminophen challenge in mice lacking C-C chemokine receptor 2.
The American journal of pathology 2000;156(4):1245-52.
1999: EM Campbell; Israel F Charo; Steven Kunkel; Robert M Strieter; Landin Boring; J Gosling; Nicholas W Lukacs
Monocyte chemoattractant protein-1 mediates cockroach allergen-induced bronchial hyperreactivity in normal but not CCR2-/- mice: the role of mast cells.
Journal of immunology (Baltimore, Md. : 1950) 1999;163(4):2160-7.
1999: Christopher A Haskell; M D Cleary; Israel F Charo
Molecular uncoupling of fractalkine-mediated cell adhesion and signal transduction. Rapid flow arrest of CX3CR1-expressing cells is independent of G-protein activation.
The Journal of biological chemistry 1999;274(15):10053-8.
1999: J Gosling; Sarah Slaymaker; L Gu; S Tseng; CH Zlot; Stephen G Young; Barrett J Rollins; Israel F Charo
MCP-1 deficiency reduces susceptibility to atherosclerosis in mice that overexpress human apolipoprotein B.
The Journal of clinical investigation 1999;103(6):773-8.
1999: S Reid; A Ritchie; Landin Boring; J Gosling; Scott Cooper; Giao Hangoc; Israel F Charo; Hal E Broxmeyer
Enhanced myeloid progenitor cell cycling and apoptosis in mice lacking the chemokine receptor, CCR2.
Blood 1999;93(5):1524-33.
1999: Israel F Charo
CCR2: from cloning to the creation of knockout mice.
Chemical immunology 1999;72():30-41.
1998: Landin Boring; J Gosling; M Cleary; Israel F Charo
Decreased lesion formation in CCR2-/- mice reveals a role for chemokines in the initiation of atherosclerosis.
Nature 1998;394(6696):894-7.
1998: Chia-Lin Tsou; Ronald P Gladue; Lauren A Carroll; Timothy J Paradis; J G Boyd; Robin T Nelson; Kuldeep S Neote; Israel F Charo
Identification of C-C chemokine receptor 1 (CCR1) as the monocyte hemofiltrate C-C chemokine (HCC)-1 receptor.
The Journal of experimental medicine 1998;188(3):603-8.
1997: H Arai; Chia-Lin Tsou; Israel F Charo
Chemotaxis in a lymphocyte cell line transfected with C-C chemokine receptor 2B: evidence that directed migration is mediated by betagamma dimers released by activation of Galphai-coupled receptors.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(26):14495-9.
1997: Landin Boring; J Gosling; Stephen W Chensue; Steven Kunkel; Robert V Farese; Hal E Broxmeyer; Israel F Charo
Impaired monocyte migration and reduced type 1 (Th1) cytokine responses in C-C chemokine receptor 2 knockout mice.
The Journal of clinical investigation 1997;100(10):2552-61.
1997: Alison D Schecter; Barrett J Rollins; Y J Zhang; Israel F Charo; John T Fallon; M Rossikhina; peter giesen; Yale Nemerson; Mark B Taubman
Tissue factor is induced by monocyte chemoattractant protein-1 in human aortic smooth muscle and THP-1 cells.
The Journal of biological chemistry 1997;272(45):28568-73.
1997: H Arai; FS Monteclaro; Chia-Lin Tsou; C Franci; Israel F Charo
Dissociation of chemotaxis from agonist-induced receptor internalization in a lymphocyte cell line transfected with CCR2B. Evidence that directed migration does not require rapid modulation of signaling at the receptor level.
The Journal of biological chemistry 1997;272(40):25037-42.
1997: FS Monteclaro; Israel F Charo
The amino-terminal domain of CCR2 is both necessary and sufficient for high affinity binding of monocyte chemoattractant protein 1. Receptor activation by a pseudo-tethered ligand.
The Journal of biological chemistry 1997;272(37):23186-90.
1997: Roberto F Speck; Kathy Wehrly; Emily J Platt; RE Atchison; Israel F Charo; David Kabat; Bruce Chesebro; Mark A Goldsmith
Selective employment of chemokine receptors as human immunodeficiency virus type 1 coreceptors determined by individual amino acids within the envelope V3 loop.
Journal of virology 1997;71(9):7136-9.
1997: J Gosling; FS Monteclaro; RE Atchison; H Arai; Chia-Lin Tsou; Mark A Goldsmith; Israel F Charo
Molecular uncoupling of C-C chemokine receptor 5-induced chemotaxis and signal transduction from HIV-1 coreceptor activity.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(10):5061-6.
1997: L M Wong; S J Myers; Chia-Lin Tsou; J Gosling; H Arai; Israel F Charo
Organization and differential expression of the human monocyte chemoattractant protein 1 receptor gene. Evidence for the role of the carboxyl-terminal tail in receptor trafficking.
The Journal of biological chemistry 1997;272(2):1038-45.
1997: FS Monteclaro; H Arai; Israel F Charo
Molecular approaches to identifying ligand binding and signaling domains of C-C chemokine receptors.
Methods in enzymology 1997;288():70-84.
1996: C Franci; J Gosling; Chia-Lin Tsou; Shaun R Coughlin; Israel F Charo
Phosphorylation by a G protein-coupled kinase inhibits signaling and promotes internalization of the monocyte chemoattractant protein-1 receptor. Critical role of carboxyl-tail serines/threonines in receptor function.
Journal of immunology (Baltimore, Md. : 1950) 1996;157(12):5606-12.
1996: RE Atchison; J Gosling; FS Monteclaro; C Franci; L Digilio; Israel F Charo; Mark A Goldsmith
Multiple extracellular elements of CCR5 and HIV-1 entry: dissociation from response to chemokines.
Science (New York, N.Y.) 1996;274(5294):1924-6.
1996: H Arai; Israel F Charo
Differential regulation of G-protein-mediated signaling by chemokine receptors.
The Journal of biological chemistry 1996;271(36):21814-9.
1996: FS Monteclaro; Israel F Charo
The amino-terminal extracellular domain of the MCP-1 receptor, but not the RANTES/MIP-1alpha receptor, confers chemokine selectivity. Evidence for a two-step mechanism for MCP-1 receptor activation.
The Journal of biological chemistry 1996;271(32):19084-92.
1996: CJ Raport; J Gosling; VL Schweickart; Patrick W Gray; Israel F Charo
Molecular cloning and functional characterization of a novel human CC chemokine receptor (CCR5) for RANTES, MIP-1beta, and MIP-1alpha.
The Journal of biological chemistry 1996;271(29):17161-6.
1996: Landin Boring; J Gosling; FS Monteclaro; A J Lusis; Chia-Lin Tsou; Israel F Charo
Molecular cloning and functional expression of murine JE (monocyte chemoattractant protein 1) and murine macrophage inflammatory protein 1alpha receptors: evidence for two closely linked C-C chemokine receptors on chromosome 9.
The Journal of biological chemistry 1996;271(13):7551-8.
1995: C Franci; L M Wong; J Van Damme; P Proost; Israel F Charo
Monocyte chemoattractant protein-3, but not monocyte chemoattractant protein-2, is a functional ligand of the human monocyte chemoattractant protein-1 receptor.
Journal of immunology (Baltimore, Md. : 1950) 1995;154(12):6511-7.
1995: S J Myers; L M Wong; Israel F Charo
Signal transduction and ligand specificity of the human monocyte chemoattractant protein-1 receptor in transfected embryonic kidney cells.
The Journal of biological chemistry 1995;270(11):5786-92.
1994: Israel F Charo; S J Myers; A Herman; C Franci; A J Connolly; Shaun R Coughlin
Molecular cloning and functional expression of two monocyte chemoattractant protein 1 receptors reveals alternative splicing of the carboxyl-terminal tails.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(7):2752-6.
1992: Nicolas Nelken; Scott J Soifer; J O'Keefe; T K Vu; Israel F Charo; Shaun R Coughlin
Thrombin receptor expression in normal and atherosclerotic human arteries.
The Journal of clinical investigation 1992;90(4):1614-21.
1992: D T Hung; T K Vu; V I Wheaton; Israel F Charo; Nicolas Nelken; N Esmon; Charles T Esmon; Shaun R Coughlin
"Mirror image" antagonists of thrombin-induced platelet activation based on thrombin receptor structure.
The Journal of clinical investigation 1992;89(2):444-50.
1991: T K Vu; V I Wheaton; D T Hung; Israel F Charo; Shaun R Coughlin
Domains specifying thrombin-receptor interaction.
Nature 1991;353(6345):674-7.
1989: D L Brown; D R Phillips; Caroline Damsky; Israel F Charo
Synthesis and expression of the fibroblast fibronectin receptor in human monocytes.
The Journal of clinical investigation 1989;84(1):366-70.
1988: D R Phillips; Israel F Charo; Leslie V Parise; L A Fitzgerald
The platelet membrane glycoprotein IIb-IIIa complex.
Blood 1988;71(4):831-43.
1987: Israel F Charo; L S Bekeart; D R Phillips
Platelet glycoprotein IIb-IIIa-like proteins mediate endothelial cell attachment to adhesive proteins and the extracellular matrix.
The Journal of biological chemistry 1987;262(21):9935-8.
1987: D R Phillips; L A Fitzgerald; Israel F Charo; Leslie V Parise
The platelet membrane glycoprotein IIb/IIIa complex. Structure, function, and relationship to adhesive protein receptors in nucleated cells.
Annals of the New York Academy of Sciences 1987;509():177-87.
1986: Israel F Charo; L A Fitzgerald; B Steiner; SC Rall; L S Bekeart; D R Phillips
Platelet glycoproteins IIb and IIIa: evidence for a family of immunologically and structurally related glycoproteins in mammalian cells.
Proceedings of the National Academy of Sciences of the United States of America 1986;83(21):8351-5.
1985: L A Fitzgerald; Israel F Charo; D R Phillips
Human and bovine endothelial cells synthesize membrane proteins similar to human platelet glycoproteins IIb and IIIa.
The Journal of biological chemistry 1985;260(20):10893-6.