FIND

researchers

DISCOVER

relevant articles

PROMOTE

your research

now for free

Steven Chatfield

Research Profile

Chemicals & Drugs

Living Beings

Procedures

Co-author Network

Publications

TOP 3
S Khan; Steven N Chatfield; Richard Stratford; J Bedwell; Matthew Bentley; S Sulsh; Rafaela Giemza; S Smith; E Bongard; Catherine Cosgrove; J Johnson; Gordon Dougan; George E Griffin; Jill Makin; David J M Lewis
Ability of SPI2 mutant of S. typhi to effectively induce antibody responses to the mucosal antigen enterotoxigenic E. coli heat labile toxin B subunit after oral delivery to humans.
Beth D Kirkpatrick; Robin McKenzie; J Patrick O'Neill; Catherine J Larsson; A Louis Bourgeois; Janet Shimko; Matthew Bentley; Jill Makin; Steven N Chatfield; Zoë Hindle; Christine Fidler; Brad E Robinson; Cassandra Ventrone; Nivedita Bansal; Colleen M Carpenter; Deborah Kutzko; Sandra Hamlet; Casey LaPointe; David N Taylor
Evaluation of Salmonella enterica serovar Typhi (Ty2 aroC-ssaV-) M01ZH09, with a defined mutation in the Salmonella pathogenicity island 2, as a live, oral typhoid vaccine in human volunteers.
Beth D Kirkpatrick; Katherine M Tenney; Catherine J Larsson; J Patrick O'Neill; Cassandra Ventrone; Matthew Bentley; Anthony Upton; Zoë Hindle; Christine Fidler; Deborah Kutzko; Regan Holdridge; Casey Lapointe; Sandra Hamlet; Steven N Chatfield
The novel oral typhoid vaccine M01ZH09 is well tolerated and highly immunogenic in 2 vaccine presentations.

Register for free to view:

Visualized networks:

See your personal network in
sophisticated graphical views

GeoTargeted Searches:

Locate experts around the world
and connect with global collaborators

Research Profiles:

See the research activity
of experts around the globe

Geonetwork of Steven Chatfield (preview)

Cities where this author has publications
Cities where co-authors of this author have publications

Flash Player Required

All Publications

2007: S Khan; Steven N Chatfield; Richard Stratford; J Bedwell; Matthew Bentley; S Sulsh; Rafaela Giemza; S Smith; E Bongard; Catherine Cosgrove; J Johnson; Gordon Dougan; George E Griffin; Jill Makin; David J M Lewis
Ability of SPI2 mutant of S. typhi to effectively induce antibody responses to the mucosal antigen enterotoxigenic E. coli heat labile toxin B subunit after oral delivery to humans.
Vaccine 2007;25(21):4175-82.
2006: Beth D Kirkpatrick; Robin McKenzie; J Patrick O'Neill; Catherine J Larsson; A Louis Bourgeois; Janet Shimko; Matthew Bentley; Jill Makin; Steven N Chatfield; Zoë Hindle; Christine Fidler; Brad E Robinson; Cassandra Ventrone; Nivedita Bansal; Colleen M Carpenter; Deborah Kutzko; Sandra Hamlet; Casey LaPointe; David N Taylor
Evaluation of Salmonella enterica serovar Typhi (Ty2 aroC-ssaV-) M01ZH09, with a defined mutation in the Salmonella pathogenicity island 2, as a live, oral typhoid vaccine in human volunteers.
Vaccine 2006;24(2):116-23.
2005: Beth D Kirkpatrick; Katherine M Tenney; Catherine J Larsson; J Patrick O'Neill; Cassandra Ventrone; Matthew Bentley; Anthony Upton; Zoë Hindle; Christine Fidler; Deborah Kutzko; Regan Holdridge; Casey Lapointe; Sandra Hamlet; Steven N Chatfield
The novel oral typhoid vaccine M01ZH09 is well tolerated and highly immunogenic in 2 vaccine presentations.
The Journal of infectious diseases 2005;192(3):360-6.
2005: Richard Stratford; Nicola D Mckelvie; Nicky Hughes; Emma Aldred; Claire Wiseman; Johanna Curtis; Trevor Bellaby; Matthew Bentley; Zoë Hindle; Frank R Brennan; Steven N Chatfield; Gordon Dougan; Shahid A Khan
Optimization of Salmonella enterica serovar typhi DeltaaroC DeltassaV derivatives as vehicles for delivering heterologous antigens by chromosomal integration and in vivo inducible promoters.
Infection and immunity 2005;73(1):362-8.
2004: Nicola D Mckelvie; Richard Stratford; Tao Wu; Trevor Bellaby; Emma Aldred; Nicky Hughes; Steven N Chatfield; Derek Pickard; Christine Hale; Gordon Dougan; Shahid A Khan
Expression of heterologous antigens in Salmonella Typhimurium vaccine vectors using the in vivo-inducible, SPI-2 promoter, ssaG.
Vaccine 2004;22(25-26):3243-55.
2003: Shahid A Khan; Richard Stratford; Tao Wu; Nicola D Mckelvie; Trevor Bellaby; Zoë Hindle; Katharine A Sinha; Shayne Eltze; Pietro Mastroeni; Derek Pickard; Gordon Dougan; Steven N Chatfield; Frank R Brennan
Salmonella typhi and S typhimurium derivatives harbouring deletions in aromatic biosynthesis and Salmonella Pathogenicity Island-2 (SPI-2) genes as vaccines and vectors.
Vaccine 2003;21(5-6):538-48.
2002: Zoë Hindle; Steven N Chatfield; Jo Phillimore; Matthew Bentley; Julie Johnson; Catherine Cosgrove; Marjan Ghaem-Maghami; Amy Sexton; Mohammad Khan; Frank R Brennan; Paul Everest; Tao Wu; Derek Pickard; David W Holden; Gordon Dougan; George E Griffin; Deborah House; Joseph D Santangelo; Shahid A Khan; Jaqueline E Shea; Robert G Feldman; David J M Lewis
Characterization of Salmonella enterica derivatives harboring defined aroC and Salmonella pathogenicity island 2 type III secretion system (ssaV) mutations by immunization of healthy volunteers.
Infection and immunity 2002;70(7):3457-67.
2000: Carol O Tacket; James E Galen; Marcelo B Sztein; Genevieve A Losonsky; Timothy L Wyant; James P Nataro; Steven Wasserman; Robert Edelman; Steven N Chatfield; Gordon Dougan; Myron M Levine
Safety and immune responses to attenuated Salmonella enterica serovar typhi oral live vector vaccines expressing tetanus toxin fragment C.
Clinical immunology (Orlando, Fla.) 2000;97(2):146-53.
2000: Mark Roberts; Steven N Chatfield; D Pickard; J Li; A Bacon
Comparison of abilities of Salmonella enterica serovar typhimurium aroA aroD and aroA htrA mutants to act as live vectors.
Infection and immunity 2000;68(10):6041-3.
2000: A Bacon; Jill Makin; P J Sizer; Inderjit Jabbal-Gill; Michael Hinchcliffe; Lisbeth Illum; Steven N Chatfield; Mark Roberts
Carbohydrate biopolymers enhance antibody responses to mucosally delivered vaccine antigens.
Infection and immunity 2000;68(10):5764-70.
2000: Carol O Tacket; Marcelo B Sztein; Steven Wasserman; Genevieve A Losonsky; Karen L Kotloff; Timothy L Wyant; James P Nataro; Robert Edelman; J Perry; P Bedford; David M Brown; Steven N Chatfield; Gordon Dougan; Myron M Levine
Phase 2 clinical trial of attenuated Salmonella enterica serovar typhi oral live vector vaccine CVD 908-htrA in U.S. volunteers.
Infection and immunity 2000;68(3):1196-201.
2000: M Sydenham; G Douce; Frances Bowe; S Ahmed; Steven N Chatfield; Gordon Dougan
Salmonella enterica serovar typhimurium surA mutants are attenuated and effective live oral vaccines.
Infection and immunity 2000;68(3):1109-15.
1999: Mark Roberts; A Bacon; J Li; Steven N Chatfield
Prior immunity to homologous and heterologous Salmonella serotypes suppresses local and systemic anti-fragment C antibody responses and protection from tetanus toxin in mice immunized with Salmonella strains expressing fragment C.
Infection and immunity 1999;67(8):3810-5.
1999: CD Jones; M Page; A Bacon; E Cahill; Matthew Bentley; Steven N Chatfield
T-cell and antibody response characterisation of a new recombinant pre-S1, pre-S2 and SHBs antigen-containing hepatitis B vaccine; demonstration of superior anti-SHBs antibody induction in responder mice.
Vaccine 1999;17(20-21):2528-37.
1999: DC Lowe; Tor C Savidge; Derek Pickard; Lars Eckmann; Martin F Kagnoff; Gordon Dougan; Steven N Chatfield
Characterization of candidate live oral Salmonella typhi vaccine strains harboring defined mutations in aroA, aroC, and htrA.
Infection and immunity 1999;67(2):700-7.
1998: CD Jones; M Page; A Bacon; E Cahill; Matthew Bentley; Steven N Chatfield
Characterization of the T- and B-cell immune response to a new recombinant pre-S1, pre-S2 and SHBs antigen containing hepatitis B vaccine (Hepagene); evidence for superior anti-SHBs antibody induction in responder mice.
Journal of viral hepatitis 1998;5 Suppl 2():5-8.
1998: Mark Roberts; J Li; A Bacon; Steven N Chatfield
Oral vaccination against tetanus: comparison of the immunogenicities of Salmonella strains expressing fragment C from the nirB and htrA promoters.
Infection and immunity 1998;66(7):3080-7.
1997: Myron M Levine; James E Galen; Eileen M Barry; FR Noriega; Carol O Tacket; Marcelo B Sztein; Steven N Chatfield; Gordon Dougan; Genevieve A Losonsky; Karen L Kotloff
Attenuated Salmonella typhi and Shigella as live oral vaccines and as live vectors.
Behring Institute Mitteilungen 1997;(98):120-3.
1997: Carol O Tacket; Marcelo B Sztein; Genevieve A Losonsky; Steven Wasserman; James P Nataro; Robert Edelman; Derek Pickard; Gordon Dougan; Steven N Chatfield; Myron M Levine
Safety of live oral Salmonella typhi vaccine strains with deletions in htrA and aroC aroD and immune response in humans.
Infection and immunity 1997;65(2):452-6.
1996: Paul Everest; J Li; G Douce; Ian G Charles; J De Azavedo; Steven N Chatfield; Gordon Dougan; Mark Roberts
Role of the Bordetella pertussis P.69/pertactin protein and the P.69/pertactin RGD motif in the adherence to and invasion of mammalian cells.
Microbiology (Reading, England) 1996;142 ( Pt 11)():3261-8.
1996: Eileen M Barry; OG Gómez-Duarte; Steven N Chatfield; R Rappuoli; Mariagrazia Pizza; Genevieve A Losonsky; James E Galen; Myron M Levine
Expression and immunogenicity of pertussis toxin S1 subunit-tetanus toxin fragment C fusions in Salmonella typhi vaccine strain CVD 908.
Infection and immunity 1996;64(10):4172-81.
1996: N Okahashi; Masato Yamamoto; John L VanCott; Steven N Chatfield; M Roberts; H Bluethmann; T Hiroi; Hiroshi Kiyono; Jerry R McGhee
Oral immunization of interleukin-4 (IL-4) knockout mice with a recombinant Salmonella strain or cholera toxin reveals that CD4+ Th2 cells producing IL-6 and IL-10 are associated with mucosal immunoglobulin A responses.
Infection and immunity 1996;64(5):1516-25.
1996: L P Londoño; Steven N Chatfield; Robert W Tindle; Karen A Herd; X M Gao; Ian H Frazer; Gordon Dougan
Immunisation of mice using Salmonella typhimurium expressing human papillomavirus type 16 E7 epitopes inserted into hepatitis B virus core antigen.
Vaccine 1996;14(6):545-52.
1996: John L VanCott; H F Staats; David W Pascual; M Roberts; Steven N Chatfield; Masato Yamamoto; M Coste; P B Carter; Hiroshi Kiyono; Jerry R McGhee
Regulation of mucosal and systemic antibody responses by T helper cell subsets, macrophages, and derived cytokines following oral immunization with live recombinant Salmonella.
Journal of immunology (Baltimore, Md. : 1950) 1996;156(4):1504-14.
1996: Masato Yamamoto; John L VanCott; N Okahashi; M Marinaro; Hiroshi Kiyono; Kohtaro Fujihashi; Raymond J Jackson; Steven N Chatfield; H Bluethmann; Jerry R McGhee
The role of Th1 and Th2 cells for mucosal IgA responses.
Annals of the New York Academy of Sciences 1996;778():64-71.
1996: Raymond J Jackson; M Marinaro; John L VanCott; Masato Yamamoto; N Okahashi; Kohtaro Fujihashi; Hiroshi Kiyono; Steven N Chatfield; Jerry R McGhee
Mucosal immunity: regulation by helper T cells and a novel method for detection.
Journal of biotechnology 1996;44(1-3):209-16.
1996: Myron M Levine; James E Galen; Eileen M Barry; FR Noriega; Steven N Chatfield; Marcelo B Sztein; Gordon Dougan; Carol O Tacket
Attenuated Salmonella as live oral vaccines against typhoid fever and as live vectors.
Journal of biotechnology 1996;44(1-3):193-6.
1995: I Cropley; G Douce; Mark Roberts; Steven N Chatfield; Mariagrazia Pizza; I Marsili; Rino Rappuoli; Gordon Dougan
Mucosal and systemic immunogenicity of a recombinant, non-ADP-ribosylating pertussis toxin: effects of formaldehyde treatment.
Vaccine 1995;13(17):1643-8.
1995: OG Gómez-Duarte; James E Galen; Steven N Chatfield; R Rappuoli; L Eidels; Myron M Levine
Expression of fragment C of tetanus toxin fused to a carboxyl-terminal fragment of diphtheria toxin in Salmonella typhi CVD 908 vaccine strain.
Vaccine 1995;13(16):1596-602.
1995: J A Chabalgoity; B Villareal-Ramos; C M Anjam Khan; Steven N Chatfield; R D de Hormaeche; Carlos E Hormaeche
Influence of preimmunization with tetanus toxoid on immune responses to tetanus toxin fragment C-guest antigen fusions in a Salmonella vaccine carrier.
Infection and immunity 1995;63(7):2564-9.
1995: Mark Roberts; A Bacon; Rino Rappuoli; Mariagrazia Pizza; I Cropley; G Douce; Gordon Dougan; M Marinaro; J McGhee; Steven N Chatfield
A mutant pertussis toxin molecule that lacks ADP-ribosyltransferase activity, PT-9K/129G, is an effective mucosal adjuvant for intranasally delivered proteins.
Infection and immunity 1995;63(6):2100-8.
1995: Paul Everest; Gad Frankel; J Li; P Lund; Steven N Chatfield; Gordon Dougan
Expression of LacZ from the htrA, nirB and groE promoters in a Salmonella vaccine strain: influence of growth in mammalian cells.
FEMS microbiology letters 1995;126(1):97-101.
1995: Steven N Chatfield; Mark Roberts; Gordon Dougan; Carlos E Hormaeche; C M Anjam Khan
The development of oral vaccines against parasitic diseases utilizing live attenuated Salmonella.
Parasitology 1995;110 Suppl():S17-24.
1994: C M Anjam Khan; B Villarreal-Ramos; R J Pierce; Raquel Demarco de Hormaeche; H McNeill; T Ali; Steven N Chatfield; André Capron; Gordon Dougan; Carlos E Hormaeche
Construction, expression, and immunogenicity of multiple tandem copies of the Schistosoma mansoni peptide 115-131 of the P28 glutathione S-transferase expressed as C-terminal fusions to tetanus toxin fragment C in a live aro-attenuated vaccine strain of Salmonella.
Journal of immunology (Baltimore, Md. : 1950) 1994;153(12):5634-42.
1994: C M Anjam Khan; B Villarreal-Ramos; R J Pierce; Gilles Riveau; Raquel Demarco de Hormaeche; H McNeill; T Ali; Neil Fairweather; Steven N Chatfield; André Capron
Construction, expression, and immunogenicity of the Schistosoma mansoni P28 glutathione S-transferase as a genetic fusion to tetanus toxin fragment C in a live Aro attenuated vaccine strain of Salmonella.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(23):11261-5.
1994: Derek Pickard; J Li; Mark Roberts; Duncan J Maskell; David Hone; Myron M Levine; Gordon Dougan; Steven N Chatfield
Characterization of defined ompR mutants of Salmonella typhi: ompR is involved in the regulation of Vi polysaccharide expression.
Infection and immunity 1994;62(9):3984-93.
1994: Raymond J Jackson; H F Staats; J Xu-Amano; I Takahashi; Hiroshi Kiyono; M E Hudson; R M Gilley; Steven N Chatfield; Jerry R McGhee
Oral vaccine models: multiple delivery systems employing tetanus toxoid.
Annals of the New York Academy of Sciences 1994;730():217-34.
1994: JA Harrison; Derek Pickard; Christopher F Higgins; A Khan; Steven N Chatfield; T Ali; Charles J Dorman; Carlos E Hormaeche; Gordon Dougan
Role of hns in the virulence phenotype of pathogenic salmonellae.
Molecular microbiology 1994;13(1):133-40.
1994: Robert W Tindle; Karen A Herd; P Londoño; Germain Fernando; Steven N Chatfield; K Malcolm; Gordon Dougan
Chimeric hepatitis B core antigen particles containing B- and Th-epitopes of human papillomavirus type 16 E7 protein induce specific antibody and T-helper responses in immunised mice.
Virology 1994;200(2):547-57.
1994: Steven N Chatfield; Mark Roberts; J Li; A Starns; Gordon Dougan
The use of live attenuated Salmonella for oral vaccination.
Developments in biological standardization 1994;82():35-42.
1993: Steven N Chatfield; Mark Roberts; P Londono; I Cropley; G Douce; Gordon Dougan
The development of oral vaccines based on live attenuated Salmonella strains.
FEMS immunology and medical microbiology 1993;7(1):1-7.
1993: Mark Roberts; I Cropley; Steven N Chatfield; Gordon Dougan
Protection of mice against respiratory Bordetella pertussis infection by intranasal immunization with P.69 and FHA.
Vaccine 1993;11(8):866-72.
1992: R Strugnell; Gordon Dougan; Steven N Chatfield; Ian G Charles; Neil Fairweather; John Tite; J L Li; J Beesley; M Roberts
Characterization of a Salmonella typhimurium aro vaccine strain expressing the P.69 antigen of Bordetella pertussis.
Infection and immunity 1992;60(10):3994-4002.
1992: Steven N Chatfield; Ian G Charles; A J Makoff; M D Oxer; Gordon Dougan; Derek Pickard; D Slater; Neil Fairweather
Use of the nirB promoter to direct the stable expression of heterologous antigens in Salmonella oral vaccine strains: development of a single-dose oral tetanus vaccine.
Bio/technology (Nature Publishing Company) 1992;10(8):888-92.
1992: K Strahan; Steven N Chatfield; John Tite; G Dougan; Carlos E Hormaeche
Impaired resistance to infection does not increase the virulence of Salmonella htrA live vaccines for mice.
Microbial pathogenesis 1992;12(4):311-7.
1992: M J Carrier; Steven N Chatfield; Gordon Dougan; U T Nowicka; D O'Callaghan; J E Beesley; Salvatore Milano; Enrico Cillari; Foo Y Liew
Expression of human IL-1 beta in Salmonella typhimurium. A model system for the delivery of recombinant therapeutic proteins in vivo.
Journal of immunology (Baltimore, Md. : 1950) 1992;148(4):1176-81.
1992: Steven N Chatfield; K Strahan; Derek Pickard; Ian G Charles; Carlos E Hormaeche; Gordon Dougan
Evaluation of Salmonella typhimurium strains harbouring defined mutations in htrA and aroA in the murine salmonellosis model.
Microbial pathogenesis 1992;12(2):145-51.
1992: Steven N Chatfield; Neil Fairweather; Ian G Charles; Derek Pickard; Myron M Levine; David Hone; M Posada; R A Strugnell; Gordon Dougan
Construction of a genetically defined Salmonella typhi Ty2 aroA, aroC mutant for the engineering of a candidate oral typhoid-tetanus vaccine.
Vaccine 1992;10(1):53-60.
1991: John Tite; Gordon Dougan; Steven N Chatfield
The involvement of tumor necrosis factor in immunity to Salmonella infection.
Journal of immunology (Baltimore, Md. : 1950) 1991;147(9):3161-4.
1991: David Hone; A M Harris; Steven N Chatfield; Gordon Dougan; Myron M Levine
Construction of genetically defined double aro mutants of Salmonella typhi.
Vaccine 1991;9(11):810-6.
1991: Ian G Charles; B C Rodgers; A J Makoff; Steven N Chatfield; D E Slater; Neil Fairweather
Synthesis of tetanus toxin fragment C in insect cells by use of a baculovirus expression system.
Infection and immunity 1991;59(5):1627-32.
1991: S Servos; Steven N Chatfield; David Hone; Myron M Levine; G Dimitriadis; Derek Pickard; Gordon Dougan; Neil Fairweather; Ian G Charles
Molecular cloning and characterization of the aroD gene encoding 3-dehydroquinase from Salmonella typhi.
Journal of general microbiology 1991;137(1):147-52.
1991: Steven N Chatfield; Charles J Dorman; C Hayward; Gordon Dougan
Role of ompR-dependent genes in Salmonella typhimurium virulence: mutants deficient in both ompC and ompF are attenuated in vivo.
Infection and immunity 1991;59(1):449-52.
1990: Steven N Chatfield; Gordon Dougan; Ian G Charles
Complete nucleotide sequence of the aroA gene from Salmonella typhi encoding 5-enolpyruvylshikimate 3-phosphate synthase.
Nucleic acids research 1990;18(20):6133.
1990: Gordon Dougan; Steven N Chatfield; M Roberts; Ian G Charles; S Comerford; L J Li; Neil Fairweather
Bacterial pathogens--a route to oral drug delivery.
Biochemical Society transactions 1990;18(5):746-8.
1990: Neil Fairweather; Steven N Chatfield; Ian G Charles; M Roberts; M Lipscombe; L J Li; D Strugnell; S Comerford; John Tite; Gordon Dougan
Use of live attenuated bacteria to stimulate immunity.
Research in microbiology 1990;141(7-8):769-73.
1990: Neil Fairweather; Steven N Chatfield; A J Makoff; R A Strugnell; J Bester; Duncan J Maskell; Gordon Dougan
Oral vaccination of mice against tetanus by use of a live attenuated Salmonella carrier.
Infection and immunity 1990;58(5):1323-6.
1989: Steven N Chatfield; R A Strugnell; Gordon Dougan
Live Salmonella as vaccines and carriers of foreign antigenic determinants.
Vaccine 1989;7(6):495-8.
1989: Ian G Charles; Gordon Dougan; Derek Pickard; Steven N Chatfield; M Smith; P Novotny; P Morrissey; Neil Fairweather
Molecular cloning and characterization of protective outer membrane protein P.69 from Bordetella pertussis.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(10):3554-8.
1989: I A Miller; Steven N Chatfield; Gordon Dougan; L Desilva; H S Joysey; Carlos E Hormaeche
Bacteriophage P22 as a vehicle for transducing cosmid gene banks between smooth strains of Salmonella typhimurium: use in identifying a role for aroD in attenuating virulent Salmonella strains.
Molecular & general genetics : MGG 1989;215(2):312-6.
1988: Gordon Dougan; Steven N Chatfield; Derek Pickard; J Bester; D O'Callaghan; Duncan J Maskell
Construction and characterization of vaccine strains of Salmonella harboring mutations in two different aro genes.
The Journal of infectious diseases 1988;158(6):1329-35.
1988: Steven N Chatfield; D S Fernie; C Penn; Gordon Dougan
Identification of the major antigens of Treponema hyodysenteriae and comparison with those of Treponema innocens.
Infection and immunity 1988;56(5):1070-5.
1988: Gordon Dougan; Duncan J Maskell; D O'Callaghan; Steven N Chatfield; Ian G Charles; Carlos E Hormaeche
Oral vaccination.
Antonie van Leeuwenhoek 1988;54(5):447-51.