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Madan Chaturvedi

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Byoungduck Park; Bokyung Sung; Vivek R Yadav; Madan M Chaturvedi; Bharat B Aggarwal
Triptolide, histone acetyltransferase inhibitor, suppresses growth and chemosensitizes leukemic cells through inhibition of gene expression regulated by TNF-TNFR1-TRADD-TRAF2-NIK-TAK1-IKK pathway.
Bharat B Aggarwal; Madan M Chaturvedi; Subash C Gupta; Ramaswamy Kannappan; Ji Hye Kim; Byoungduck Park; Kanokkarn Phromnoi; Sahdeo Prasad; Seema Prasad; Simone Reuter; Chitra Sundaram; Vivek R Yadev; Bokyung Sung
Identification of novel anti-inflammatory agents from Ayurvedic medicine for prevention of chronic diseases: "reverse pharmacology" and "bedside to bench" approach.
Madan M Chaturvedi; B Sung; V R Yadav; R Kannappan; B B Aggarwal
NF-κB addiction and its role in cancer: 'one size does not fit all'.

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All Publications

2011: Byoungduck Park; Bokyung Sung; Vivek R Yadav; Madan M Chaturvedi; Bharat B Aggarwal
Triptolide, histone acetyltransferase inhibitor, suppresses growth and chemosensitizes leukemic cells through inhibition of gene expression regulated by TNF-TNFR1-TRADD-TRAF2-NIK-TAK1-IKK pathway.
Biochemical pharmacology 2011;82(9):1134-44.
2011: Bharat B Aggarwal; Madan M Chaturvedi; Subash C Gupta; Ramaswamy Kannappan; Ji Hye Kim; Byoungduck Park; Kanokkarn Phromnoi; Sahdeo Prasad; Seema Prasad; Simone Reuter; Chitra Sundaram; Vivek R Yadev; Bokyung Sung
Identification of novel anti-inflammatory agents from Ayurvedic medicine for prevention of chronic diseases: "reverse pharmacology" and "bedside to bench" approach.
Current drug targets 2011;12(11):1595-653.
2011: Madan M Chaturvedi; B Sung; V R Yadav; R Kannappan; B B Aggarwal
NF-κB addiction and its role in cancer: 'one size does not fit all'.
Oncogene 2011;30(14):1615-30.
2010: Hareesh B. Nair; Bokyung Sung; Vivek R Yadav; Ramaswamy Kannappan; Madan M Chaturvedi; Bharat B Aggarwal
Delivery of antiinflammatory nutraceuticals by nanoparticles for the prevention and treatment of cancer.
Biochemical pharmacology 2010;80(12):1833-43.
2010: Vivek R Yadav; Bokyung Sung; Sahdeo Prasad; Ramaswamy Kannappan; Sung Gook Cho; Mingyao Liu; Madan M Chaturvedi; Bharat B Aggarwal
Celastrol suppresses invasion of colon and pancreatic cancer cells through the downregulation of expression of CXCR4 chemokine receptor.
Journal of molecular medicine (Berlin, Germany) 2010;88(12):1243-53.
2010: Subash C Gupta; Sahdeo Prasad; Simone Reuter; Ramaswamy Kannappan; Vivek R Yadav; Jayaraj Ravindran; Padmanabhan S Hema; Madan M Chaturvedi; Mangalam Nair; Bharat B Aggarwal
Modification of cysteine 179 of IkappaBalpha kinase by nimbolide leads to down-regulation of NF-kappaB-regulated cell survival and proliferative proteins and sensitization of tumor cells to chemotherapeutic agents.
The Journal of biological chemistry 2010;285(46):35406-17.
2010: Simone Reuter; Sahdeo Prasad; Kanokkarn Phromnoi; Jayaraj Ravindran; Bokyung Sung; Vivek R Yadav; Ramaswamy Kannappan; Madan M Chaturvedi; Bharat B Aggarwal
Thiocolchicoside exhibits anticancer effects through downregulation of NF-κB pathway and its regulated gene products linked to inflammation and cancer.
Cancer prevention research (Philadelphia, Pa.) 2010;3(11):1462-72.
2010: Vivek R Yadav; Sahdeo Prasad; Ramaswamy Kannappan; Jayaraj Ravindran; Madan M Chaturvedi; Lauri Vaahtera; Jaakko Parkkinen; Bharat B Aggarwal
Cyclodextrin-complexed curcumin exhibits anti-inflammatory and antiproliferative activities superior to those of curcumin through higher cellular uptake.
Biochemical pharmacology 2010;80(7):1021-32.
2010: Sahdeo Prasad; Vivek R Yadav; Chitra Sundaram; Simone Reuter; Padmanabhan S Hema; Mangalam S Nair; Madan M Chaturvedi; Bharat B Aggarwal
Crotepoxide chemosensitizes tumor cells through inhibition of expression of proliferation, invasion, and angiogenic proteins linked to proinflammatory pathway.
The Journal of biological chemistry 2010;285(35):26987-97.
2010: Ramaswamy Kannappan; Jayaraj Ravindran; Sahdeo Prasad; Bokyung Sung; Vivek R Yadav; Simone Reuter; Madan M Chaturvedi; Bharat B Aggarwal
Gamma-tocotrienol promotes TRAIL-induced apoptosis through reactive oxygen species/extracellular signal-regulated kinase/p53-mediated upregulation of death receptors.
Molecular cancer therapeutics 2010;9(8):2196-207.
2010: Sahdeo Prasad; Kannokarn Phromnoi; Vivek R Yadav; Madan M Chaturvedi; Bharat B Aggarwal
Targeting inflammatory pathways by flavonoids for prevention and treatment of cancer.
Planta medica 2010;76(11):1044-63.
2008: Gautam Sethi; Kwang Seok Ahn; Bokyung Sung; Ajaikumar Kunnumakkara; Madan M Chaturvedi; Bharat B Aggarwal
SH-5, an AKT inhibitor potentiates apoptosis and inhibits invasion through the suppression of anti-apoptotic, proliferative and metastatic gene products regulated by IkappaBalpha kinase activation.
Biochemical pharmacology 2008;76(11):1404-16.
2008: Kwang Seok Ahn; Gautam Sethi; Madan M Chaturvedi; Bharat B Aggarwal
Simvastatin, 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor, suppresses osteoclastogenesis induced by receptor activator of nuclear factor-kappaB ligand through modulation of NF-kappaB pathway.
International journal of cancer. Journal international du cancer 2008;123(8):1733-40.
2008: Manoj Pandey; Bokyung Sung; Ajaikumar Kunnumakkara; Gautam Sethi; Madan M Chaturvedi; Bharat B Aggarwal
Berberine modifies cysteine 179 of IkappaBalpha kinase, suppresses nuclear factor-kappaB-regulated antiapoptotic gene products, and potentiates apoptosis.
Cancer research 2008;68(13):5370-9.
2008: Bokyung Sung; Manoj Pandey; Kwang Seok Ahn; Tingfang Yi; Madan M Chaturvedi; Mingyao Liu; Bharat B Aggarwal
Anacardic acid (6-nonadecyl salicylic acid), an inhibitor of histone acetyltransferase, suppresses expression of nuclear factor-kappaB-regulated gene products involved in cell survival, proliferation, invasion, and inflammation through inhibition of the inhibitory subunit of nuclear factor-kappaBalpha kinase, leading to potentiation of apoptosis.
Blood 2008;111(10):4880-91.
2008: Bokyung Sung; Manoj Pandey; Yuki Nakajima; Hiroshi Nishida; Tetsuya Konishi; Madan M Chaturvedi; Bharat B Aggarwal
Identification of a novel blocker of IkappaBalpha kinase activation that enhances apoptosis and inhibits proliferation and invasion by suppressing nuclear factor-kappaB.
Molecular cancer therapeutics 2008;7(1):191-201.
2007: Manoj Pandey; Bokyung Sung; Kwang Seok Ahn; Ajaikumar Kunnumakkara; Madan M Chaturvedi; Bharat B Aggarwal
Gambogic acid, a novel ligand for transferrin receptor, potentiates TNF-induced apoptosis through modulation of the nuclear factor-kappaB signaling pathway.
Blood 2007;110(10):3517-25.
2007: Gautam Sethi; Kwang Seok Ahn; Madan M Chaturvedi; Bharat B Aggarwal
Epidermal growth factor (EGF) activates nuclear factor-kappaB through IkappaBalpha kinase-independent but EGF receptor-kinase dependent tyrosine 42 phosphorylation of IkappaBalpha.
Oncogene 2007;26(52):7324-32.
2007: Kwang Seok Ahn; Xing Gong; Gautam Sethi; Madan M Chaturvedi; Anil K Jaiswal; Bharat B Aggarwal
Deficiency of NRH:quinone oxidoreductase 2 differentially regulates TNF signaling in keratinocytes: up-regulation of apoptosis correlates with down-regulation of cell survival kinases.
Cancer research 2007;67(20):10004-11.
2007: Yasunari Takada; Bokyung Sung; Gautam Sethi; Madan M Chaturvedi; Bharat B Aggarwal
Evidence that genetic deletion of the TNF receptor p60 or p80 inhibits Fas mediated apoptosis in macrophages.
Biochemical pharmacology 2007;74(7):1057-64.
2007: Kwang Seok Ahn; Gautam Sethi; Ta-Hsiang Chao; Saskia T C Neuteboom; Madan M Chaturvedi; Michael A Palladino; Anas Younes; Bharat B Aggarwal
Salinosporamide A (NPI-0052) potentiates apoptosis, suppresses osteoclastogenesis, and inhibits invasion through down-modulation of NF-kappaB regulated gene products.
Blood 2007;110(7):2286-95.
2007: D G Jackson-Bernitsas; Haruyo Ichikawa; Yasunari Takada; Jeffrey N Myers; X L Lin; Bryant G Darnay; Madan M Chaturvedi; Bharat B Aggarwal
Evidence that TNF-TNFR1-TRADD-TRAF2-RIP-TAK1-IKK pathway mediates constitutive NF-kappaB activation and proliferation in human head and neck squamous cell carcinoma.
Oncogene 2007;26(10):1385-97.
2006: Gautam Sethi; Kwang Seok Ahn; Santosh K Sandur; Xin Lin; Madan M Chaturvedi; Bharat B Aggarwal
Indirubin enhances tumor necrosis factor-induced apoptosis through modulation of nuclear factor-kappa B signaling pathway.
The Journal of biological chemistry 2006;281(33):23425-35.
2000: gagan chainy; Sunil K Manna; Madan M Chaturvedi; Bharat B Aggarwal
Anethole blocks both early and late cellular responses transduced by tumor necrosis factor: effect on NF-kappaB, AP-1, JNK, MAPKK and apoptosis.
Oncogene 2000;19(25):2943-50.
1998: K Natarajan; Sunil K Manna; Madan M Chaturvedi; Bharat B Aggarwal
Protein tyrosine kinase inhibitors block tumor necrosis factor-induced activation of nuclear factor-kappaB, degradation of IkappaBalpha, nuclear translocation of p65, and subsequent gene expression.
Archives of biochemistry and biophysics 1998;352(1):59-70.
1998: R Mukherjee; S Singh; Madan M Chaturvedi; Bharat B Aggarwal
Evidence for a synergistic role of two types of human tumor necrosis factor receptors for the ligand-dependent activation of the nuclear transcription factor NF-kappaB.
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 1998;18(2):117-23.
1997: Madan M Chaturvedi; Addanki Kumar; Bryant G Darnay; gagan chainy; S Agarwal; Bharat B Aggarwal
Sanguinarine (pseudochelerythrine) is a potent inhibitor of NF-kappaB activation, IkappaBalpha phosphorylation, and degradation.
The Journal of biological chemistry 1997;272(48):30129-34.
1995: Bryant G Darnay; Saurabh Singh; Madan M Chaturvedi; Bharat B Aggarwal
The p60 tumor necrosis factor (TNF) receptor-associated kinase (TRAK) binds residues 344-397 within the cytoplasmic domain involved in TNF signaling.
The Journal of biological chemistry 1995;270(25):14867-70.
1995: K Totpal; Madan M Chaturvedi; Ruth Lapushin; Bharat B Aggarwal
Retinoids downregulate both p60 and p80 forms of tumor necrosis factor receptors in human histiocytic lymphoma U-937 cells.
Blood 1995;85(12):3547-55.
1995: Bharat B Aggarwal; K Totpal; Ruth Lapushin; Madan M Chaturvedi; Olivia M Pereira-Smith; J R Smith
Diminished responsiveness of senescent normal human fibroblasts to TNF-dependent proliferation and interleukin production is not due to its effect on the receptors or on the activation of a nuclear factor NF-kappa B.
Experimental cell research 1995;218(1):381-8.
1994: Shrikanth A G Reddy; Madan M Chaturvedi; Bryant G Darnay; H Chan; M Higuchi; Bharat B Aggarwal
Reconstitution of nuclear factor kappa B activation induced by tumor necrosis factor requires membrane-associated components. Comparison with pathway activated by ceramide.
The Journal of biological chemistry 1994;269(41):25369-72.
1994: Madan M Chaturvedi; M Higuchi; Bharat B Aggarwal
Effect of tumor necrosis factors, interferons, interleukins, and growth factors on the activation of NF-kappa B: evidence for lack of correlation with cell proliferation.
Lymphokine and cytokine research 1994;13(5):309-13.
1994: Madan M Chaturvedi; Ruth Lapushin; Bharat B Aggarwal
Tumor necrosis factor and lymphotoxin. Qualitative and quantitative differences in the mediation of early and late cellular response.
The Journal of biological chemistry 1994;269(20):14575-83.
1994: L Zhang; M Higuchi; K Totpal; Madan M Chaturvedi; Bharat B Aggarwal
Staurosporine induces the cell surface expression of both forms of human tumor necrosis factor receptors on myeloid and epithelial cells and modulates ligand-induced cellular response.
The Journal of biological chemistry 1994;269(14):10270-9.