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Dharminder Chauhan

Research Profile

Disorders

Multiple Myeloma

Anatomy

Chemicals & Drugs

Physiology

Living Beings

Mouse

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Publications

TOP 3
Panisinee Lawasut; Michelle Maglio; Constantine Mitsiades; Kenneth C Anderson; Dharminder Chauhan; Claire Fabre; Catriona Hayes; Teru Hideshima; Jacob Laubach; Paul G Richardson
New proteasome inhibitors in myeloma.
Ze Tian; Jian-jun Zhao; Samir B Amin; Allison J Berger; Dharminder Chauhan; Yiguo Hu; Paul Richardson; Yu-Tzu Tai; Kenneth C Anderson
Investigational agent MLN9708/2238 targets tumor-suppressor miR33b in MM cells.
Michele Cea; Dharminder Chauhan; Francesca Cottini; Mariateresa Fulciniti; Marco Gobbi; Teru Hideshima; Jana Jakubikova; Sun-Young Kong; Nikhil Munshi; Alessio Nencioni; Franco Patrone; Paul Richardson; Aldo Roccaro; Antonio Sacco; Yu-Tzu Tai; Antonia Cagnetta; Teresa Calimeri; Kenneth C Anderson
Targeting NAD+ salvage pathway induces autophagy in multiple myeloma cells via mTORC1 and extracellular signal-regulated kinase (ERK1/2) inhibition.

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All Publications

2012: Panisinee Lawasut; Michelle Maglio; Constantine Mitsiades; Kenneth C Anderson; Dharminder Chauhan; Claire Fabre; Catriona Hayes; Teru Hideshima; Jacob Laubach; Paul G Richardson
New proteasome inhibitors in myeloma.
Current hematologic malignancy reports 2012;7(4):258-66.
2012: Ze Tian; Jian-jun Zhao; Samir B Amin; Allison J Berger; Dharminder Chauhan; Yiguo Hu; Paul Richardson; Yu-Tzu Tai; Kenneth C Anderson
Investigational agent MLN9708/2238 targets tumor-suppressor miR33b in MM cells.
Blood 2012;120(19):3958-67.
2012: Michele Cea; Dharminder Chauhan; Francesca Cottini; Mariateresa Fulciniti; Marco Gobbi; Teru Hideshima; Jana Jakubikova; Sun-Young Kong; Nikhil Munshi; Alessio Nencioni; Franco Patrone; Paul Richardson; Aldo Roccaro; Antonio Sacco; Yu-Tzu Tai; Antonia Cagnetta; Teresa Calimeri; Kenneth C Anderson
Targeting NAD+ salvage pathway induces autophagy in multiple myeloma cells via mTORC1 and extracellular signal-regulated kinase (ERK1/2) inhibition.
Blood 2012;120(17):3519-29.
2012: Dharminder Chauhan; Mariaterresa Fulcinniti; Teru Hideshima; Benedikt M Kessler; William D Kingsbury; Matthew P Kodrasov; K G Suresh Kumar; Craig A Leach; Jeffrey L McDermott; Stephane Minvielle; Nikhil Munshi; Benjamin Nicholson; Robert Orlowski; Paul Richardson; Parantu K Shah; Ze Tian; Joseph Weinstock; Bin Zhou; Mikael Altun; Ruben Carrasco; Kenneth C Anderson
A small molecule inhibitor of ubiquitin-specific protease-7 induces apoptosis in multiple myeloma cells and overcomes bortezomib resistance.
Cancer cell 2012;22(3):345-58.
2011: Dharminder Chauhan; Noopur Raje; Arghya Ray; Paul Richardson; Ajita V Singh; Madhavi Bandi; Kenneth C Anderson
Preclinical evaluation of a novel SIRT1 modulator SRT1720 in multiple myeloma cells.
British journal of haematology 2011;155(5):588-98.
2011: klaus podar; Martin Sattler; Yu-Tzu Tai; Giovanni Tonon; Sonia Vallet; Alexander Zimmerhackl; Dharminder Chauhan; Mariateresa Fulciniti; Ursula Hainz; Niels Halama; Dirk Jäger; Dian L Olson; Kenneth C Anderson
The selective adhesion molecule inhibitor Natalizumab decreases multiple myeloma cell growth in the bone marrow microenvironment: therapeutic implications.
British journal of haematology 2011;155(4):438-48.
2011: Dharminder Chauhan; Deborah Kuhn; Robert Z Orlowski; Noopur Raje; Paul G Richardson; Ze Tian; Bin Zhou; Kenneth C Anderson
In vitro and in vivo selective antitumor activity of a novel orally bioavailable proteasome inhibitor MLN9708 against multiple myeloma cells.
Clinical cancer research : an official journal of the American Association for Cancer Research 2011;17(16):5311-21.
2011: Ajita V Singh; Madhavi Bandi; Noopur Raje; Paul Richardson; Michael A Palladino; Dharminder Chauhan; Kenneth C Anderson
A novel vascular disrupting agent plinabulin triggers JNK-mediated apoptosis and inhibits angiogenesis in multiple myeloma cells.
Blood 2011;117(21):5692-700.
2011: Loredana Santo; Teru Hideshima; Diana Cirstea; Madhavi Bandi; Erik A Nelson; Gullu Gorgun; Scott Rodig; Sonia Vallet; Samantha Pozzi; Kishan Patel; Christine Unitt; Matt Squires; Yiguo Hu; Dharminder Chauhan; Anuj Mahindra; Nikhil C Munshi; Kenneth C Anderson; Noopur Raje
Antimyeloma activity of a multitargeted kinase inhibitor, AT9283, via potent Aurora kinase and STAT3 inhibition either alone or in combination with lenalidomide.
Clinical cancer research : an official journal of the American Association for Cancer Research 2011;17(10):3259-71.
2011: Dharminder Chauhan; Kenneth C Anderson
Proteasome inhibition, the pursuit of new cancer therapeutics, and the adaptor molecule p130Cas.
BMC biology 2011;9():72.
2011: Ajita V Singh; Madhavi Bandi; Monette A Aujay; Christopher J Kirk; David E Hark; Noopur Raje; Dharminder Chauhan; Kenneth C Anderson
PR-924, a selective inhibitor of the immunoproteasome subunit LMP-7, blocks multiple myeloma cell growth both in vitro and in vivo.
British journal of haematology 2011;152(2):155-63.
2011: W Song; Yu-Tzu Tai; Z Tian; Teru Hideshima; Dharminder Chauhan; P Nanjappa; Mark A Exley; Kenneth C Anderson; Nikhil C Munshi
HDAC inhibition by LBH589 affects the phenotype and function of human myeloid dendritic cells.
Leukemia 2011;25(1):161-8.
2010: Dharminder Chauhan; Ajita V Singh; Monette Aujay; Christopher J Kirk; Madhavi Bandi; Bryan Ciccarelli; Noopur Raje; Paul Richardson; Kenneth C Anderson
A novel orally active proteasome inhibitor ONX 0912 triggers in vitro and in vivo cytotoxicity in multiple myeloma.
Blood 2010;116(23):4906-15.
2010: Teru Hideshima; Constantine S Mitsiades; Hiroshi Ikeda; Dharminder Chauhan; Noopur Raje; Gullu Gorgun; Hiromasa Hideshima; Nikhil C Munshi; Paul G Richardson; Daniel R Carrasco; Kenneth C Anderson
A proto-oncogene BCL6 is up-regulated in the bone marrow microenvironment in multiple myeloma cells.
Blood 2010;115(18):3772-5.
2010: Kihyun Kim; Sun-Young Kong; Mariateresa Fulciniti; Xianfeng Li; Weihua Song; Sabikun Nahar; Peter C Burger; Mathew J Rumizen; klaus podar; Dharminder Chauhan; Teru Hideshima; Nikhil C Munshi; Paul Richardson; Ann Clark; Janet Ogden; Andreas Goutopoulos; Luca Rastelli; Kenneth C Anderson; Yu-Tzu Tai
Blockade of the MEK/ERK signalling cascade by AS703026, a novel selective MEK1/2 inhibitor, induces pleiotropic anti-myeloma activity in vitro and in vivo.
British journal of haematology 2010;149(4):537-49.
2010: Ajita V Singh; Michael A Palladino; George Kenneth Lloyd; Barbara C Potts; Dharminder Chauhan; Kenneth C Anderson
Pharmacodynamic and efficacy studies of the novel proteasome inhibitor NPI-0052 (marizomib) in a human plasmacytoma xenograft murine model.
British journal of haematology 2010;149(4):550-9.
2010: Sonia Vallet; Siddhartha Mukherjee; Nileshwari Vaghela; Teru Hideshima; Mariateresa Fulciniti; Samantha Pozzi; Loredana Santo; Diana Cirstea; Kishan Patel; Aliyah R Sohani; Alex Guimaraes; Wanling Xie; Dharminder Chauhan; Jesse A Schoonmaker; Eyal Attar; Michael Churchill; Edie Weller; Nikhil Munshi; Jasbir S Seehra; Ralph Weissleder; Kenneth C Anderson; David T Scadden; Noopur Raje
Activin A promotes multiple myeloma-induced osteolysis and is a promising target for myeloma bone disease.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(11):5124-9.
2010: Dharminder Chauhan; Ajita V Singh; Bryan Ciccarelli; Paul G Richardson; Michael A Palladino; Kenneth C Anderson
Combination of novel proteasome inhibitor NPI-0052 and lenalidomide trigger in vitro and in vivo synergistic cytotoxicity in multiple myeloma.
Blood 2010;115(4):834-45.
2009: Melissa G Ooi; Patrick J Hayden; Vassiliki Kotoula; Douglas W McMillin; Elpida Charalambous; Emily Daskalaki; Noopur S Raje; Nikhil C Munshi; Dharminder Chauhan; Teru Hideshima; Leutz Buon; Martin Clynes; Peter O'Gorman; Paul G Richardson; Constantine S Mitsiades; Kenneth C Anderson; Nicholas Mitsiades
Interactions of the Hdm2/p53 and proteasome pathways may enhance the antitumor activity of bortezomib.
Clinical cancer research : an official journal of the American Association for Cancer Research 2009;15(23):7153-60.
2009: Joseph M Negri; Douglas W McMillin; Jake Delmore; Nicholas Mitsiades; Patrick Hayden; Steffen Klippel; Teru Hideshima; Dharminder Chauhan; Nikhil C Munshi; Carolyn A Buser; John Pollard; Paul G Richardson; Kenneth C Anderson; Constantine S Mitsiades
In vitro anti-myeloma activity of the Aurora kinase inhibitor VE-465.
British journal of haematology 2009;147(5):672-6.
2009: Dharminder Chauhan; Ajita V Singh; Mohan Brahmandam; Ruben Carrasco; Madhavi Bandi; Teru Hideshima; Giada Bianchi; klaus podar; Yu-Tzu Tai; Constantine Mitsiades; Noopur Raje; David L Jaye; Shaji K Kumar; Paul Richardson; Nikhil C Munshi; Kenneth C Anderson
Functional interaction of plasmacytoid dendritic cells with multiple myeloma cells: a therapeutic target.
Cancer cell 2009;16(4):309-23.
2009: Jacob P Laubach; Constantine S Mitsiades; Anuj Mahindra; Robert L Schlossman; Teru Hideshima; Dharminder Chauhan; Nicole A Carreau; Irene M Ghobrial; Noopur Raje; Nikhil C Munshi; Kenneth C Anderson; Paul G Richardson
Novel therapies in the treatment of multiple myeloma.
Journal of the National Comprehensive Cancer Network : JNCCN 2009;7(9):947-60.
2009: Teru Hideshima; Hiroshi Ikeda; Dharminder Chauhan; Yutaka Okawa; Noopur Raje; klaus podar; Constantine S Mitsiades; Nikhil C Munshi; Paul G Richardson; Ruben D Carrasco; Kenneth C Anderson
Bortezomib induces canonical nuclear factor-kappaB activation in multiple myeloma cells.
Blood 2009;114(5):1046-52.
2009: Mariateresa Fulciniti; Pierfrancesco Tassone; Teru Hideshima; Sonia Vallet; Puru Nanjappa; Seth A Ettenberg; Zhenxin Shen; Nipun Patel; Yu-Tzu Tai; Dharminder Chauhan; Constantine S Mitsiades; Rao H Prabhala; Noopur Raje; Kenneth C Anderson; David R Stover; Nikhil C Munshi
Anti-DKK1 mAb (BHQ880) as a potential therapeutic agent for multiple myeloma.
Blood 2009;114(2):371-9.
2009: Jing Zhang; Martin Sattler; Giovanni Tonon; Clemens Grabher; Samir Lababidi; Alexander Zimmerhackl; Marc S Raab; Sonia Vallet; Yiming Zhou; Marie-Astrid Cartron; Teru Hideshima; Yu-Tzu Tai; Dharminder Chauhan; Kenneth C Anderson; Klaus Podar
Targeting angiogenesis via a c-Myc/hypoxia-inducible factor-1alpha-dependent pathway in multiple myeloma.
Cancer research 2009;69(12):5082-90.
2009: Teru Hideshima; Dharminder Chauhan; Tanyel Kiziltepe; Hiroshi Ikeda; Yutaka Okawa; klaus podar; Noopur Raje; Alexei Protopopov; Nikhil C Munshi; Paul G Richardson; Ruben D Carrasco; Kenneth C Anderson
Biologic sequelae of I{kappa}B kinase (IKK) inhibition in multiple myeloma: therapeutic implications.
Blood 2009;113(21):5228-36.
2009: Constantine S Mitsiades; Teru Hideshima; Dharminder Chauhan; Douglas W McMillin; Steffen Klippel; Jacob P Laubach; Nikhil C Munshi; Kenneth C Anderson; Paul G Richardson
Emerging treatments for multiple myeloma: beyond immunomodulatory drugs and bortezomib.
Seminars in hematology 2009;46(2):166-75.
2009: Marc S Raab; Iris Breitkreutz; Giovanni Tonon; Jing Zhang; Patrick J Hayden; Thu Nguyen; Johannes H Fruehauf; Boris K Lin; Dharminder Chauhan; Teru Hideshima; Nikhil C Munshi; Kenneth C Anderson; Klaus Podar
Targeting PKC: a novel role for beta-catenin in ER stress and apoptotic signaling.
Blood 2009;113(7):1513-21.
2009: Jacob P Laubach; Constantine S Mitsiades; Teru Hideshima; Robert Schlossman; Dharminder Chauhan; Nikhil Munshi; Irene Ghobrial; Nicole Carreau; Kenneth C Anderson; Paul G Richardson
Bortezomib in the management of multiple myeloma.
Cancer management and research 2009;1():107-17.
2009: Renate Burger; Steven Le Gouill; Yu-Tzu Tai; Reshma Shringarpure; Pierfrancesco Tassone; Paola Neri; klaus podar; Laurence Catley; Teru Hideshima; Dharminder Chauhan; Eian Caulder; Claire L Neilan; Kris Vaddi; Jun Li; Martin Gramatzki; Jordan S Fridman; Kenneth C Anderson
Janus kinase inhibitor INCB20 has antiproliferative and apoptotic effects on human myeloma cells in vitro and in vivo.
Molecular cancer therapeutics 2009;8(1):26-35.
2008: Erik A Nelson; Sarah R Walker; Alicia Kepich; Laurie B Gashin; Teru Hideshima; Hiroshi Ikeda; Dharminder Chauhan; Kenneth C Anderson; David A Frank
Nifuroxazide inhibits survival of multiple myeloma cells by directly inhibiting STAT3.
Blood 2008;112(13):5095-102.
2008: Constantine S Mitsiades; Enrique M Ocio; Atanasio Pandiella; Patricia Maiso; Consuelo Gajate; Mercedes Garayoa; David Vilanova; Juan Carlos Montero; Nicholas Mitsiades; Ciaran J McMullan; Nikhil C Munshi; Teru Hideshima; Dharminder Chauhan; Pablo Aviles; Gabriel Otero; Glynn Faircloth; M Victoria Mateos; Paul G Richardson; Faustino Mollinedo; Jesus F San-Miguel; Kenneth C Anderson
Aplidin, a marine organism-derived compound with potent antimyeloma activity in vitro and in vivo.
Cancer research 2008;68(13):5216-25.
2008: Kenji Ishitsuka; Teru Hideshima; Paola Neri; Sonia Vallet; Norihiko Shiraishi; Yutaka Okawa; Zhenxin Shen; Noopur Raje; Tanyel Kiziltepe; Enrique M Ocio; Dharminder Chauhan; Pierfrancesco Tassone; Nikhil C Munshi; Robert M Campbell; Alfonso De Dios; Chuan Shih; James J Starling; Kazuo Tamura; Kenneth C Anderson
p38 mitogen-activated protein kinase inhibitor LY2228820 enhances bortezomib-induced cytotoxicity and inhibits osteoclastogenesis in multiple myeloma; therapeutic implications.
British journal of haematology 2008;141(5):598-606.
2008: Aldo Roccaro; Xavier Leleu; Antonio Sacco; Xiaoying Jia; Molly Melhem; Anne-Sophie Moreau; Hai T Ngo; Judith M Runnels; Abdelkareem Azab; Feda Azab; Nicholas Burwick; Mena Farag; Steve P Treon; Michael A Palladino; Teru Hideshima; Dharminder Chauhan; Kenneth C Anderson; Irene M Ghobrial
Dual targeting of the proteasome regulates survival and homing in Waldenstrom macroglobulinemia.
Blood 2008;111(9):4752-63.
2008: Dharminder Chauhan; Ajita Singh; Mohan Brahmandam; klaus podar; Teru Hideshima; Paul Richardson; Nikhil C Munshi; Michael A Palladino; Kenneth C Anderson
Combination of proteasome inhibitors bortezomib and NPI-0052 trigger in vivo synergistic cytotoxicity in multiple myeloma.
Blood 2008;111(3):1654-64.
2008: klaus podar; S L Gouill; J Zhang; J T Opferman; E Zorn; Yu-Tzu Tai; Teru Hideshima; M Amiot; Dharminder Chauhan; Jean-Luc Harousseau; Kenneth C Anderson
A pivotal role for Mcl-1 in Bortezomib-induced apoptosis.
Oncogene 2008;27(6):721-31.
2008: Dharminder Chauhan; Giada Bianchi; Kenneth C Anderson
Targeting the UPS as therapy in multiple myeloma.
BMC biochemistry 2008;9 Suppl 1():S1.
2008: Dharminder Chauhan; Teru Hideshima; Kenneth C Anderson
Targeting proteasomes as therapy in multiple myeloma.
Advances in experimental medicine and biology 2008;615():251-60.
2007: klaus podar; Paul G Richardson; Teru Hideshima; Dharminder Chauhan; Kenneth C Anderson
The malignant clone and the bone-marrow environment.
Best practice & research. Clinical haematology 2007;20(4):597-612.
2007: Constantine S Mitsiades; Douglas W McMillin; Steffen Klippel; Teru Hideshima; Dharminder Chauhan; Paul G Richardson; Nikhil C Munshi; Kenneth C Anderson
The role of the bone marrow microenvironment in the pathophysiology of myeloma and its significance in the development of more effective therapies.
Hematology/oncology clinics of North America 2007;21(6):1007-34, vii-viii.
2007: Paola Neri; Pierfrancesco Tassone; Masood Ahmad Shammas; Hiroshi Yasui; Ernestina Schipani; Ramesh Babu Batchu; Simona Blotta; Rao H Prabhala; Laurence Catley; Makoto Hamasaki; Teru Hideshima; Dharminder Chauhan; Gary S Jacob; Donald Picker; Salvatore Venuta; Kenneth C Anderson; Nikhil C Munshi
Biological pathways and in vivo antitumor activity induced by Atiprimod in myeloma.
Leukemia 2007;21(12):2519-26.
2007: klaus podar; Marc S Raab; Dharminder Chauhan; Kenneth C Anderson
The therapeutic role of targeting protein kinase C in solid and hematologic malignancies.
Expert opinion on investigational drugs 2007;16(10):1693-707.
2007: Paola Neri; Shaji Kumar; Mariateresa Fulciniti; Sonia Vallet; Shweta Chhetri; Sidhartha Mukherjee; Yu-Tzu Tai; Dharminder Chauhan; Pierfrancesco Tassone; Salvatore Venuta; Nikhil C Munshi; Teru Hideshima; Kenneth C Anderson; Noopur Raje
Neutralizing B-cell activating factor antibody improves survival and inhibits osteoclastogenesis in a severe combined immunodeficient human multiple myeloma model.
Clinical cancer research : an official journal of the American Association for Cancer Research 2007;13(19):5903-9.
2007: Iris Breitkreutz; Marc S Raab; Sonia Vallet; Teru Hideshima; Noopur Raje; Dharminder Chauhan; Nikhil C Munshi; Paul G Richardson; Kenneth C Anderson
Targeting MEK1/2 blocks osteoclast differentiation, function and cytokine secretion in multiple myeloma.
British journal of haematology 2007;139(1):55-63.
2007: Teru Hideshima; Laurence Catley; Noopur Raje; Dharminder Chauhan; klaus podar; Constantine S Mitsiades; Yu-Tzu Tai; Sonia Vallet; Tanyel Kiziltepe; Enrique M Ocio; Hiroshi Ikeda; Yutaka Okawa; Hiromasa Hideshima; Nikhil C Munshi; Hiroshi Yasui; Paul G Richardson; Kenneth C Anderson
Inhibition of Akt induces significant downregulation of survivin and cytotoxicity in human multiple myeloma cells.
British journal of haematology 2007;138(6):783-91.
2007: Yu-Tzu Tai; Mariateresa Fulciniti; Teru Hideshima; Weihua Song; Merav Leiba; Xian-Feng Li; Matthew Rumizen; Peter C Burger; Aileen Morrison; klaus podar; Dharminder Chauhan; Pierfrancesco Tassone; Paul Richardson; Nikhil C Munshi; Irene M Ghobrial; Kenneth C Anderson
Targeting MEK induces myeloma-cell cytotoxicity and inhibits osteoclastogenesis.
Blood 2007;110(5):1656-63.
2007: Tanyel Kiziltepe; Teru Hideshima; Kenji Ishitsuka; Enrique M Ocio; Noopur Raje; Laurence Catley; Chun-Qi Li; Laura J Trudel; Hiroshi Yasui; Sonia Vallet; Jeffery L Kutok; Dharminder Chauhan; Constantine S Mitsiades; Joseph E Saavedra; Gerald N Wogan; Larry K Keefer; Paul J Shami; Kenneth C Anderson
JS-K, a GST-activated nitric oxide generator, induces DNA double-strand breaks, activates DNA damage response pathways, and induces apoptosis in vitro and in vivo in human multiple myeloma cells.
Blood 2007;110(2):709-18.
2007: Laurence Catley; Teru Hideshima; Dharminder Chauhan; Paola Neri; Pierfrancesco Tassone; Roderick Bronson; Weihua Song; Yu-Tzu Tai; Nikhil C Munshi; Kenneth C Anderson
Alkyl phospholipid perifosine induces myeloid hyperplasia in a murine myeloma model.
Experimental hematology 2007;35(7):1038-46.
2007: Tanyel Kiziltepe; Teru Hideshima; Laurence Catley; Noopur Raje; Hiroshi Yasui; Norihiko Shiraishi; Yutaka Okawa; Hiroshi Ikeda; Sonia Vallet; Samantha Pozzi; Kenji Ishitsuka; Enrique M Ocio; Dharminder Chauhan; Kenneth C Anderson
5-Azacytidine, a DNA methyltransferase inhibitor, induces ATR-mediated DNA double-strand break responses, apoptosis, and synergistic cytotoxicity with doxorubicin and bortezomib against multiple myeloma cells.
Molecular cancer therapeutics 2007;6(6):1718-27.
2007: Dharminder Chauhan; Mugdha Velankar; M Brahmandam; Teru Hideshima; klaus podar; Paul Richardson; Robert Schlossman; Irene M Ghobrial; Noopur Raje; Nikhil C Munshi; Kenneth C Anderson
A novel Bcl-2/Bcl-X(L)/Bcl-w inhibitor ABT-737 as therapy in multiple myeloma.
Oncogene 2007;26(16):2374-80.
2007: klaus podar; Paul G Richardson; Dharminder Chauhan; Kenneth C Anderson
Targeting the vascular endothelial growth factor pathway in the treatment of multiple myeloma.
Expert review of anticancer therapy 2007;7(4):551-66.
2007: Hiroshi Yasui; Teru Hideshima; H Ikeda; Enrique M Ocio; Tanyel Kiziltepe; Sonia Vallet; Y Okawa; Paola Neri; Kumar Sukhdeo; klaus podar; Dharminder Chauhan; Paul G Richardson; Noopur Raje; Daniel R Carrasco; Kenneth C Anderson
Novel etodolac analog SDX-308 (CEP-18082) induces cytotoxicity in multiple myeloma cells associated with inhibition of beta-catenin/TCF pathway.
Leukemia 2007;21(3):535-40.
2007: klaus podar; Marc S Raab; Giovanni Tonon; Martin Sattler; Daniela Barilà; Jing Zhang; Yu-Tzu Tai; Hiroshi Yasui; Noopur Raje; Ronald A DePinho; Teru Hideshima; Dharminder Chauhan; Kenneth C Anderson
Up-regulation of c-Jun inhibits proliferation and induces apoptosis via caspase-triggered c-Abl cleavage in human multiple myeloma.
Cancer research 2007;67(4):1680-8.
2007: klaus podar; Marc S Raab; Jing Zhang; Douglas W McMillin; Iris Breitkreutz; Yu-Tzu Tai; Boris K Lin; Nikhil C Munshi; Teru Hideshima; Dharminder Chauhan; Kenneth C Anderson
Targeting PKC in multiple myeloma: in vitro and in vivo effects of the novel, orally available small-molecule inhibitor enzastaurin (LY317615.HCl).
Blood 2007;109(4):1669-77.
2007: Dharminder Chauhan; Paola Neri; Mugdha Velankar; klaus podar; Teru Hideshima; Mariateresa Fulciniti; Pierfrancesco Tassone; Noopur Raje; Constantine S Mitsiades; Nicholas Mitsiades; Paul Richardson; Leigh Zawel; Mary Tran; Nikhil C Munshi; Kenneth C Anderson
Targeting mitochondrial factor Smac/DIABLO as therapy for multiple myeloma (MM).
Blood 2007;109(3):1220-7.
2007: Paul G Richardson; Constantine S Mitsiades; Robert Schlossman; Irene M Ghobrial; Teru Hideshima; Dharminder Chauhan; Nikhil C Munshi; Kenneth C Anderson
The treatment of relapsed and refractory multiple myeloma.
Hematology / the Education Program of the American Society of Hematology. American Society of Hematology. Education Program 2007;():317-23.
2006: klaus podar; Giovanni Tonon; Martin Sattler; Yu-Tzu Tai; Steven Legouill; Hiroshi Yasui; Kenji Ishitsuka; Shaji Kumar; Rakesh Kumar; Lini Pandite; Teru Hideshima; Dharminder Chauhan; Kenneth C Anderson
The small-molecule VEGF receptor inhibitor pazopanib (GW786034B) targets both tumor and endothelial cells in multiple myeloma.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(51):19478-83.
2006: Laurence Catley; Ellen Weisberg; Tanyel Kiziltepe; Yu-Tzu Tai; Teru Hideshima; Paola Neri; Pierfrancesco Tassone; Peter Atadja; Dharminder Chauhan; Nikhil C Munshi; Kenneth C Anderson
Aggresome induction by proteasome inhibitor bortezomib and alpha-tubulin hyperacetylation by tubulin deacetylase (TDAC) inhibitor LBH589 are synergistic in myeloma cells.
Blood 2006;108(10):3441-9.
2006: Dharminder Chauhan; Teru Hideshima; Kenneth C Anderson
A novel proteasome inhibitor NPI-0052 as an anticancer therapy.
British journal of cancer 2006;95(8):961-5.
2006: Teru Hideshima; Paola Neri; Pierfrancesco Tassone; Hiroshi Yasui; Kenji Ishitsuka; Noopur Raje; Dharminder Chauhan; klaus podar; Constantine S Mitsiades; Lenny Dang; Nikhil C Munshi; Paul Richardson; David P Schenkein; Kenneth C Anderson
MLN120B, a novel IkappaB kinase beta inhibitor, blocks multiple myeloma cell growth in vitro and in vivo.
Clinical cancer research : an official journal of the American Association for Cancer Research 2006;12(19):5887-94.
2006: Reshma Shringarpure; Laurence Catley; Deepak Bhole; Renate Burger; klaus podar; Yu-Tzu Tai; Benedikt Kessler; Paul J Galardy; Hidde L Ploegh; Pierfrancesco Tassone; Teru Hideshima; Constantine S Mitsiades; Nikhil C Munshi; Dharminder Chauhan; Kenneth C Anderson
Gene expression analysis of B-lymphoma cells resistant and sensitive to bortezomib.
British journal of haematology 2006;134(2):145-56.
2006: Yu-Tzu Tai; Xian-Feng Li; Iris Breitkreutz; Weihua Song; Paola Neri; Laurence Catley; klaus podar; Teru Hideshima; Dharminder Chauhan; Noopur Raje; Robert Schlossman; Paul Richardson; Nikhil C Munshi; Kenneth C Anderson
Role of B-cell-activating factor in adhesion and growth of human multiple myeloma cells in the bone marrow microenvironment.
Cancer research 2006;66(13):6675-82.
2006: Lisa J A Crawford; Brian Walker; Huib Ovaa; Dharminder Chauhan; Kenneth C Anderson; T C M Morris; Alexandra E Irvine
Comparative selectivity and specificity of the proteasome inhibitors BzLLLCOCHO, PS-341, and MG-132.
Cancer research 2006;66(12):6379-86.
2006: Teru Hideshima; Laurence Catley; Hiroshi Yasui; Kenji Ishitsuka; Noopur Raje; Constantine S Mitsiades; klaus podar; Nikhil C Munshi; Dharminder Chauhan; Paul G Richardson; Kenneth C Anderson
Perifosine, an oral bioactive novel alkylphospholipid, inhibits Akt and induces in vitro and in vivo cytotoxicity in human multiple myeloma cells.
Blood 2006;107(10):4053-62.
2006: Shaji Kumar; Noopur Raje; Teru Hideshima; Kenji Ishitsuka; klaus podar; Steven Le Gouille; Dharminder Chauhan; Paul Richardson; Nikhil C Munshi; Kenneth C Anderson
FQPD, a novel immunomodulatory drug, has significant in vitro activity in multiple myeloma.
British journal of haematology 2006;132(6):698-704.
2006: Constantine S Mitsiades; Nicholas Mitsiades; Ciaran McMullan; Vassiliki Poulaki; Andrew L Kung; Faith E Davies; Gareth Morgan; Masaharu Akiyama; Reshma Shringarpure; Nikhil C Munshi; Paul G Richardson; Teru Hideshima; Dharminder Chauhan; Xuesong Gu; Charles Bailey; Marie Joseph; Towia Libermann; Neal Rosen; Kenneth C Anderson
Antimyeloma activity of heat shock protein-90 inhibition.
Blood 2006;107(3):1092-100.
2006: Rao H Prabhala; Paola Neri; Jooeun E Bae; Pierfrancesco Tassone; Masood Ahmad Shammas; Charles K Allam; John F Daley; Dharminder Chauhan; Elizabeth Blanchard; Hemant S Thatte; Kenneth C Anderson; Nikhil C Munshi
Dysfunctional T regulatory cells in multiple myeloma.
Blood 2006;107(1):301-4.
2005: Teru Hideshima; James E Bradner; Dharminder Chauhan; Kenneth C Anderson
Intracellular protein degradation and its therapeutic implications.
Clinical cancer research : an official journal of the American Association for Cancer Research 2005;11(24 Pt 1):8530-3.
2005: Yu-Tzu Tai; Xian-Feng Li; Laurence Catley; Rory Coffey; Iris Breitkreutz; Jooeun Bae; Weihua Song; klaus podar; Teru Hideshima; Dharminder Chauhan; Robert Schlossman; Paul Richardson; Steve P Treon; Iqbal Grewal; Nikhil C Munshi; Kenneth C Anderson
Immunomodulatory drug lenalidomide (CC-5013, IMiD3) augments anti-CD40 SGN-40-induced cytotoxicity in human multiple myeloma: clinical implications.
Cancer research 2005;65(24):11712-20.
2005: Dharminder Chauhan; Laurence Catley; Guilan Li; klaus podar; Teru Hideshima; Mugdha Velankar; Constantine S Mitsiades; Nicholas Mitsiades; Hiroshi Yasui; Anthony Letai; Huib Ovaa; Celia R Berkers; Benjamin Nicholson; Ta-Hsiang Chao; Saskia T C Neuteboom; Paul Richardson; Michael A Palladino; Kenneth C Anderson
A novel orally active proteasome inhibitor induces apoptosis in multiple myeloma cells with mechanisms distinct from Bortezomib.
Cancer cell 2005;8(5):407-19.
2005: Dharminder Chauhan; Guilan Li; klaus podar; Teru Hideshima; Paola Neri; Deli He; Nicholas Mitsiades; Paul Richardson; Yan Chang; Joanne Schindler; Bradley Carver; Kenneth C Anderson
A novel carbohydrate-based therapeutic GCS-100 overcomes bortezomib resistance and enhances dexamethasone-induced apoptosis in multiple myeloma cells.
Cancer research 2005;65(18):8350-8.
2005: Teru Hideshima; Dharminder Chauhan; Paul Richardson; Kenneth C Anderson
Identification and validation of novel therapeutic targets for multiple myeloma.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2005;23(26):6345-50.
2005: Kenji Ishitsuka; Teru Hideshima; Makoto Hamasaki; Noopur Raje; Shaji Kumar; klaus podar; Steven Le Gouill; Norihiko Shiraishi; Hiroshi Yasui; Aldo Roccaro; Yu-Zu Tai; Dharminder Chauhan; Robert Fram; Kazuo Tamura; Jugnu Jain; Kenneth C Anderson
Novel inosine monophosphate dehydrogenase inhibitor VX-944 induces apoptosis in multiple myeloma cells primarily via caspase-independent AIF/Endo G pathway.
Oncogene 2005;24(38):5888-96.
2005: Kenji Ishitsuka; Teru Hideshima; Makoto Hamasaki; Noopur Raje; Shaji Kumar; Hiromasa Hideshima; Norihiko Shiraishi; Hiroshi Yasui; Aldo Roccaro; Paul Richardson; klaus podar; Steven Le Gouill; Dharminder Chauhan; Kazuo Tamura; Jack Arbiser; Kenneth C Anderson
Honokiol overcomes conventional drug resistance in human multiple myeloma by induction of caspase-dependent and -independent apoptosis.
Blood 2005;106(5):1794-800.
2005: Hiroshi Yasui; Teru Hideshima; Noopur Raje; Aldo Roccaro; Norihiko Shiraishi; Shaji Kumar; Makoto Hamasaki; Kenji Ishitsuka; Yu-Tzu Tai; klaus podar; Laurence Catley; Constantine S Mitsiades; Paul G Richardson; Rainer Albert; Volker Brinkmann; Dharminder Chauhan; Kenneth C Anderson
FTY720 induces apoptosis in multiple myeloma cells and overcomes drug resistance.
Cancer research 2005;65(16):7478-84.
2005: Laurence Catley; Yu-Tzu Tai; Dharminder Chauhan; Kenneth C Anderson
Perspectives for combination therapy to overcome drug-resistant multiple myeloma.
Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy 2005;8(4):205-18.
2005: Noopur Raje; Shaji Kumar; Teru Hideshima; Aldo Roccaro; Kenji Ishitsuka; Hiroshi Yasui; Norihiko Shiraishi; Dharminder Chauhan; Nikhil C Munshi; Simon R Green; Kenneth C Anderson
Seliciclib (CYC202 or R-roscovitine), a small-molecule cyclin-dependent kinase inhibitor, mediates activity via down-regulation of Mcl-1 in multiple myeloma.
Blood 2005;106(3):1042-7.
2005: Hiroshi Yasui; Teru Hideshima; Makoto Hamasaki; Aldo Roccaro; Norihiko Shiraishi; Shaji Kumar; Pierfrancesco Tassone; Kenji Ishitsuka; Noopur Raje; Yu-Tzu Tai; klaus podar; Dharminder Chauhan; Lorenzo Leoni; Sarath Kanekal; Gary Elliott; Nikhil C Munshi; Kenneth C Anderson
SDX-101, the R-enantiomer of etodolac, induces cytotoxicity, overcomes drug resistance, and enhances the activity of dexamethasone in multiple myeloma.
Blood 2005;106(2):706-12.
2005: Teru Hideshima; James E Bradner; Jason Wong; Dharminder Chauhan; Paul Richardson; Stuart L Schreiber; Kenneth C Anderson
Small-molecule inhibition of proteasome and aggresome function induces synergistic antitumor activity in multiple myeloma.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(24):8567-72.
2005: Pierfrancesco Tassone; Paola Neri; Renate Burger; Rocco Savino; Masood Ahmad Shammas; Laurence Catley; klaus podar; Dharminder Chauhan; Serena Masciari; Antonella Gozzini; Pierosandro Tagliaferri; Salvatore Venuta; Nikhil C Munshi; Kenneth C Anderson
Combination therapy with interleukin-6 receptor superantagonist Sant7 and dexamethasone induces antitumor effects in a novel SCID-hu In vivo model of human multiple myeloma.
Clinical cancer research : an official journal of the American Association for Cancer Research 2005;11(11):4251-8.
2005: Teru Hideshima; Dharminder Chauhan; Kenji Ishitsuka; Hiroshi Yasui; Noopur Raje; Shaji Kumar; klaus podar; Constantine S Mitsiades; Hiromasa Hideshima; Lynn Bonham; Nikhil C Munshi; Paul G Richardson; Jack W Singer; Kenneth C Anderson
Molecular characterization of PS-341 (bortezomib) resistance: implications for overcoming resistance using lysophosphatidic acid acyltransferase (LPAAT)-beta inhibitors.
Oncogene 2005;24(19):3121-9.
2005: klaus podar; Teru Hideshima; Dharminder Chauhan; Kenneth C Anderson
Targeting signalling pathways for the treatment of multiple myeloma.
Expert opinion on therapeutic targets 2005;9(2):359-81.
2005: Dharminder Chauhan; Teru Hideshima; Constantine S Mitsiades; Paul Richardson; Kenneth C Anderson
Proteasome inhibitor therapy in multiple myeloma.
Molecular cancer therapeutics 2005;4(4):686-92.
2005: Jeong H Kim; Stephanie C Chu; Jessica L Gramlich; Yuri B Pride; Emily Babendreier; Dharminder Chauhan; Ravi Salgia; klaus podar; James D Griffin; Martin Sattler
Activation of the PI3K/mTOR pathway by BCR-ABL contributes to increased production of reactive oxygen species.
Blood 2005;105(4):1717-23.
2005: Teru Hideshima; klaus podar; Dharminder Chauhan; Kenneth C Anderson
Cytokines and signal transduction.
Best practice & research. Clinical haematology 2005;18(4):509-24.
2005: Dharminder Chauhan; Teru Hideshima; Kenneth C Anderson
Proteasome inhibition in multiple myeloma: therapeutic implication.
Annual review of pharmacology and toxicology 2005;45():465-76.
2005: Toshiaki Hayashi; Teru Hideshima; Masaharu Akiyama; klaus podar; Hiroshi Yasui; Noopur Raje; Shaji Kumar; Dharminder Chauhan; Steve P Treon; Paul G Richardson; Kenneth C Anderson
Molecular mechanisms whereby immunomodulatory drugs activate natural killer cells: clinical application.
British journal of haematology 2005;128(2):192-203.
2005: Boris Lin; Laurence Catley; Richard LeBlanc; Constantine S Mitsiades; Renate Burger; Yu-Tzu Tai; klaus podar; Markus Wartmann; Dharminder Chauhan; James D Griffin; Kenneth C Anderson
Patupilone (epothilone B) inhibits growth and survival of multiple myeloma cells in vitro and in vivo.
Blood 2005;105(1):350-7.
2004: Noopur Raje; Shaji Kumar; Teru Hideshima; Kenji Ishitsuka; Dharminder Chauhan; Constantine S Mitsiades; klaus podar; Steven Le Gouill; Paul Richardson; Nikhil C Munshi; David I Stirling; Joseph H Antin; Kenneth C Anderson
Combination of the mTOR inhibitor rapamycin and CC-5013 has synergistic activity in multiple myeloma.
Blood 2004;104(13):4188-93.
2004: Laurence Catley; Yu-Tzu Tai; Reshma Shringarpure; Renate Burger; Moni Thi Son; klaus podar; Pierfrancesco Tassone; Dharminder Chauhan; Teru Hideshima; Louis Denis; Paul Richardson; Nikhil C Munshi; Kenneth C Anderson
Proteasomal degradation of topoisomerase I is preceded by c-Jun NH2-terminal kinase activation, Fas up-regulation, and poly(ADP-ribose) polymerase cleavage in SN38-mediated cytotoxicity against multiple myeloma.
Cancer research 2004;64(23):8746-53.
2004: Teru Hideshima; klaus podar; Dharminder Chauhan; Kenji Ishitsuka; Constantine S Mitsiades; Yu-Tzu Tai; Makoto Hamasaki; Noopur Raje; Hiromasa Hideshima; George F Schreiner; Aaron N Nguyen; Tony A Navas; Nikhil C Munshi; Paul G Richardson; Linda S Higgins; Kenneth C Anderson
p38 MAPK inhibition enhances PS-341 (bortezomib)-induced cytotoxicity against multiple myeloma cells.
Oncogene 2004;23(54):8766-76.
2004: Toshiaki Hayashi; Teru Hideshima; Aaron N Nguyen; Olivier Munoz; klaus podar; Makoto Hamasaki; Kenji Ishitsuka; Hiroshi Yasui; Paul Richardson; Sarvajit Chakravarty; Alison Murphy; Dharminder Chauhan; Linda S Higgins; Kenneth C Anderson
Transforming growth factor beta receptor I kinase inhibitor down-regulates cytokine secretion and multiple myeloma cell growth in the bone marrow microenvironment.
Clinical cancer research : an official journal of the American Association for Cancer Research 2004;10(22):7540-6.
2004: Steven Le Gouill; klaus podar; Martine Amiot; Teru Hideshima; Dharminder Chauhan; Kenji Ishitsuka; Shaji Kumar; Noopur Raje; Paul G Richardson; Jean-Luc Harousseau; Kenneth C Anderson
VEGF induces Mcl-1 up-regulation and protects multiple myeloma cells against apoptosis.
Blood 2004;104(9):2886-92.
2004: klaus podar; Reshma Shringarpure; Yu-Tzu Tai; Melissa Simoncini; Martin Sattler; Kenji Ishitsuka; Paul G Richardson; Teru Hideshima; Dharminder Chauhan; Kenneth C Anderson
Caveolin-1 is required for vascular endothelial growth factor-triggered multiple myeloma cell migration and is targeted by bortezomib.
Cancer research 2004;64(20):7500-6.
2004: Dharminder Chauhan; Guilan Li; klaus podar; Teru Hideshima; Constantine S Mitsiades; Robert Schlossman; Nikhil C Munshi; Paul Richardson; Finbarr E Cotter; Kenneth C Anderson
Targeting mitochondria to overcome conventional and bortezomib/proteasome inhibitor PS-341 resistance in multiple myeloma (MM) cells.
Blood 2004;104(8):2458-66.
2004: klaus podar; Gustavo Mostoslavsky; Martin Sattler; Yu-Tzu Tai; Toshiaki Hayashi; Laurence Catley; Teru Hideshima; Richard C Mulligan; Dharminder Chauhan; Kenneth C Anderson
Critical role for hematopoietic cell kinase (Hck)-mediated phosphorylation of Gab1 and Gab2 docking proteins in interleukin 6-induced proliferation and survival of multiple myeloma cells.
The Journal of biological chemistry 2004;279(20):21658-65.
2004: Noopur Raje; Teru Hideshima; Faith E Davies; Dharminder Chauhan; Steve P Treon; Gloria Young; Yu-Tzu Tai; David Avigan; Jianlin Gong; Robert Schlossman; Paul Richardson; Donald Kufe; Kenneth C Anderson
Tumour cell/dendritic cell fusions as a vaccination strategy for multiple myeloma.
British journal of haematology 2004;125(3):343-52.
2004: klaus podar; Laurence Catley; Yu-Tzu Tai; Reshma Shringarpure; Pedro Carvalho; Toshiaki Hayashi; Renate Burger; Robert Schlossman; Paul G Richardson; Lini Pandite; Rakesh Kumar; Teru Hideshima; Dharminder Chauhan; Kenneth C Anderson
GW654652, the pan-inhibitor of VEGF receptors, blocks the growth and migration of multiple myeloma cells in the bone marrow microenvironment.
Blood 2004;103(9):3474-9.
2004: Dharminder Chauhan; Guilan Li; Teru Hideshima; klaus podar; Reshma Shringarpure; Constantine S Mitsiades; Nikhil C Munshi; Patricia Yew; Kenneth C Anderson
Blockade of ubiquitin-conjugating enzyme CDC34 enhances anti-myeloma activity of Bortezomib/Proteasome inhibitor PS-341.
Oncogene 2004;23(20):3597-602.
2004: Yu-Tzu Tai; Laurence Catley; Constantine S Mitsiades; Renate Burger; klaus podar; Reshma Shringpaure; Teru Hideshima; Dharminder Chauhan; Makoto Hamasaki; Kenji Ishitsuka; Paul Richardson; Steve P Treon; Nikhil C Munshi; Kenneth C Anderson
Mechanisms by which SGN-40, a humanized anti-CD40 antibody, induces cytotoxicity in human multiple myeloma cells: clinical implications.
Cancer research 2004;64(8):2846-52.
2004: Dharminder Chauhan; Guilan Li; klaus podar; Teru Hideshima; Reshma Shringarpure; Laurence Catley; Constantine S Mitsiades; Nikhil C Munshi; Yu-Tzu Tai; Nanjoo Suh; Gordon W Gribble; Tadashi Honda; Robert Schlossman; Paul Richardson; Michael B. Sporn; Kenneth C Anderson
The bortezomib/proteasome inhibitor PS-341 and triterpenoid CDDO-Im induce synergistic anti-multiple myeloma (MM) activity and overcome bortezomib resistance.
Blood 2004;103(8):3158-66.
2004: Constantine S Mitsiades; Nicholas Mitsiades; Ciaran McMullan; Vassiliki Poulaki; Reshma Shringarpure; Masaharu Akiyama; Teru Hideshima; Dharminder Chauhan; Marie Joseph; Towia Libermann; Carlos García-Echeverría; Mark A Pearson; Francesco Hofmann; Kenneth C Anderson; Andrew L Kung
Inhibition of the insulin-like growth factor receptor-1 tyrosine kinase activity as a therapeutic strategy for multiple myeloma, other hematologic malignancies, and solid tumors.
Cancer cell 2004;5(3):221-30.
2004: Dharminder Chauhan; Guilan Li; Daniel Auclair; Teru Hideshima; klaus podar; Nicholas Mitsiades; Constantine S Mitsiades; Lan Bo Chen; Nikhil C Munshi; S Saxena; Kenneth C Anderson
2-Methoxyestardiol and bortezomib/proteasome-inhibitor overcome dexamethasone-resistance in multiple myeloma cells by modulating Heat Shock Protein-27.
Apoptosis : an international journal on programmed cell death 2004;9(2):149-55.
2004: Richard LeBlanc; Teru Hideshima; Laurence Catley; Reshma Shringarpure; Renate Burger; Nicholas Mitsiades; Constantine S Mitsiades; Puneet Cheema; Dharminder Chauhan; Paul G Richardson; Kenneth C Anderson; Nikhil C Munshi
Immunomodulatory drug costimulates T cells via the B7-CD28 pathway.
Blood 2004;103(5):1787-90.
2004: Nikhil C Munshi; Teru Hideshima; Daniel R Carrasco; Masood Ahmad Shammas; Daniel Auclair; Faith Davies; Nicholas Mitsiades; Constantine S Mitsiades; Ryung S. Kim; Cheng Li; S Vincent Rajkumar; Rafael Fonseca; Lief Bergsagel; Dharminder Chauhan; Kenneth C Anderson
Identification of genes modulated in multiple myeloma using genetically identical twin samples.
Blood 2004;103(5):1799-806.
2004: Constantine S Mitsiades; Nicholas Mitsiades; Ciaran McMullan; Vassiliki Poulaki; Reshma Shringarpure; Teru Hideshima; Masaharu Akiyama; Dharminder Chauhan; Nikhil C Munshi; Xuesong Gu; Charles Bailey; Marie Joseph; Towia Libermann; Victoria M Richon; Paul A Marks; Kenneth C Anderson
Transcriptional signature of histone deacetylase inhibition in multiple myeloma: biological and clinical implications.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(2):540-5.
2003: Faith E Davies; Ann M Dring; Cheng Li; Andy C Rawstron; Masood Ahmad Shammas; Sheila M O'Connor; James A L Fenton; Teru Hideshima; Dharminder Chauhan; Isabella T Tai; Elizabeth Robinson; Daniel Auclair; Karen Rees; David Gonzalez; A John Ashcroft; Ranjit DasGupta; Constantine S Mitsiades; Nicholas Mitsiades; Lan Bo Chen; Wing H Wong; Nikhil C Munshi; Gareth J Morgan; Kenneth C Anderson
Insights into the multistep transformation of MGUS to myeloma using microarray expression analysis.
Blood 2003;102(13):4504-11.
2003: Teru Hideshima; Dharminder Chauhan; Toshiaki Hayashi; klaus podar; Masaharu Akiyama; Constantine S Mitsiades; Nicholas Mitsiades; Baoqing Gong; Lynn Bonham; Peter de Vries; Nikhil C Munshi; Paul G Richardson; Jack W Singer; Kenneth C Anderson
Antitumor activity of lysophosphatidic acid acyltransferase-beta inhibitors, a novel class of agents, in multiple myeloma.
Cancer research 2003;63(23):8428-36.
2003: Teru Hideshima; Toshiaki Hayashi; Dharminder Chauhan; Masaharu Akiyama; Paul Richardson; Kenneth C Anderson
Biologic sequelae of c-Jun NH(2)-terminal kinase (JNK) activation in multiple myeloma cell lines.
Oncogene 2003;22(54):8797-801.
2003: Teru Hideshima; Dharminder Chauhan; Toshiaki Hayashi; Masaharu Akiyama; Nicholas Mitsiades; Constantine S Mitsiades; klaus podar; Nikhil C Munshi; Paul G Richardson; Kenneth C Anderson
Proteasome inhibitor PS-341 abrogates IL-6 triggered signaling cascades via caspase-dependent downregulation of gp130 in multiple myeloma.
Oncogene 2003;22(52):8386-93.
2003: Dharminder Chauhan; Guilan Li; Teru Hideshima; klaus podar; Constantine S Mitsiades; Nicholas Mitsiades; Laurence Catley; Yu-Tzu Tai; Toshiaki Hayashi; Reshma Shringarpure; Renate Burger; Nikhil C Munshi; Yasuyuki Ohtake; Satya Saxena; Kenneth C Anderson
Hsp27 inhibits release of mitochondrial protein Smac in multiple myeloma cells and confers dexamethasone resistance.
Blood 2003;102(9):3379-86.
2003: Constantine S Mitsiades; Nicholas Mitsiades; Ron T Bronson; Dharminder Chauhan; Nikhil C Munshi; Steve P Treon; Christopher A Maxwell; Linda M Pilarski; Teru Hideshima; Robert M Hoffman; Kenneth C Anderson
Fluorescence imaging of multiple myeloma cells in a clinically relevant SCID/NOD in vivo model: biologic and clinical implications.
Cancer research 2003;63(20):6689-96.
2003: Dharminder Chauhan; Guilan Li; Reshma Shringarpure; klaus podar; Yasuyuki Ohtake; Teru Hideshima; Kenneth C Anderson
Blockade of Hsp27 overcomes Bortezomib/proteasome inhibitor PS-341 resistance in lymphoma cells.
Cancer research 2003;63(19):6174-7.
2003: Laurence Catley; Ellen Weisberg; Yu-Tzu Tai; Peter Atadja; Stacy W Remiszewski; Teru Hideshima; Nicholas Mitsiades; Reshma Shringarpure; Richard LeBlanc; Dharminder Chauhan; Nikhil C Munshi; Robert Schlossman; Paul Richardson; James Griffin; Kenneth C Anderson
NVP-LAQ824 is a potent novel histone deacetylase inhibitor with significant activity against multiple myeloma.
Blood 2003;102(7):2615-22.
2003: Dharminder Chauhan; Guilan Li; Martin Sattler; klaus podar; Constantine S Mitsiades; Nicholas Mitsiades; Nikhil C Munshi; Teru Hideshima; Kenneth C Anderson
Superoxide-dependent and -independent mitochondrial signaling during apoptosis in multiple myeloma cells.
Oncogene 2003;22(40):6296-300.
2003: Yu-Tzu Tai; klaus podar; Laurence Catley; Yu-Hua Tseng; Masaharu Akiyama; Reshma Shringarpure; Renate Burger; Teru Hideshima; Dharminder Chauhan; Nicholas Mitsiades; Paul Richardson; Nikhil C Munshi; C Ronald Kahn; Constantine S Mitsiades; Kenneth C Anderson
Insulin-like growth factor-1 induces adhesion and migration in human multiple myeloma cells via activation of beta1-integrin and phosphatidylinositol 3'-kinase/AKT signaling.
Cancer research 2003;63(18):5850-8.
2003: Masood Ahmad Shammas; Robert J Shmookler Reis; Masaharu Akiyama; Hemanta Koley; Dharminder Chauhan; Teru Hideshima; Raj K Goyal; Laurence H Hurley; Kenneth C Anderson; Nikhil C Munshi
Telomerase inhibition and cell growth arrest by G-quadruplex interactive agent in multiple myeloma.
Molecular cancer therapeutics 2003;2(9):825-33.
2003: Toshiaki Hayashi; Teru Hideshima; Masaharu Akiyama; Noopur Raje; Paul Richardson; Dharminder Chauhan; Kenneth C Anderson
Ex vivo induction of multiple myeloma-specific cytotoxic T lymphocytes.
Blood 2003;102(4):1435-42.
2003: Dharminder Chauhan; Teru Hideshima; Kenneth C Anderson
Apoptotic signaling in multiple myeloma: therapeutic implications.
International journal of hematology 2003;78(2):114-20.
2003: Dharminder Chauhan; Kenneth C Anderson
Mechanisms of cell death and survival in multiple myeloma (MM): Therapeutic implications.
Apoptosis : an international journal on programmed cell death 2003;8(4):337-43.
2003: Dharminder Chauhan; Guilan Li; Teru Hideshima; klaus podar; Constantine S Mitsiades; Nicholas Mitsiades; Nikhil C Munshi; Surender Kharbanda; Kenneth C Anderson
JNK-dependent release of mitochondrial protein, Smac, during apoptosis in multiple myeloma (MM) cells.
The Journal of biological chemistry 2003;278(20):17593-6.
2003: Nicholas Mitsiades; Constantine S Mitsiades; Paul G Richardson; Ciaran McMullan; Vassiliki Poulaki; Galinos Fanourakis; Robert Schlossman; Dharminder Chauhan; Nikhil C Munshi; Teru Hideshima; Victoria M Richon; Paul A Marks; Kenneth C Anderson
Molecular sequelae of histone deacetylase inhibition in human malignant B cells.
Blood 2003;101(10):4055-62.
2003: Toshiaki Hayashi; Steve P Treon; Teru Hideshima; Yu-Tzu Tai; Masaharu Akiyama; Paul Richardson; Dharminder Chauhan; Iqbal Grewal; Kenneth C Anderson
Recombinant humanized anti-CD40 monoclonal antibody triggers autologous antibody-dependent cell-mediated cytotoxicity against multiple myeloma cells.
British journal of haematology 2003;121(4):592-6.
2003: Dharminder Chauhan; Guilan Li; Daniel Auclair; Teru Hideshima; Paul Richardson; klaus podar; Nicholas Mitsiades; Constantine S Mitsiades; Cheng Li; Ryung S. Kim; Nikhil C Munshi; Lan Bo Chen; Wing Wong; Kenneth C Anderson
Identification of genes regulated by 2-methoxyestradiol (2ME2) in multiple myeloma cells using oligonucleotide arrays.
Blood 2003;101(9):3606-14.
2003: Stephanie Greenstein; Nancy L Krett; Yoshihiro Kurosawa; Chunguang Ma; Dharminder Chauhan; Teru Hideshima; Kenneth C Anderson; Steven T Rosen
Characterization of the MM.1 human multiple myeloma (MM) cell lines: a model system to elucidate the characteristics, behavior, and signaling of steroid-sensitive and -resistant MM cells.
Experimental hematology 2003;31(4):271-82.
2003: Nicholas Mitsiades; Constantine S Mitsiades; Paul G Richardson; Vassiliki Poulaki; Yu-Tzu Tai; Dharminder Chauhan; Galinos Fanourakis; Xuesong Gu; Charles Bailey; Marie Joseph; Towia Libermann; Robert Schlossman; Nikhil C Munshi; Teru Hideshima; Kenneth C Anderson
The proteasome inhibitor PS-341 potentiates sensitivity of multiple myeloma cells to conventional chemotherapeutic agents: therapeutic applications.
Blood 2003;101(6):2377-80.
2003: klaus podar; Yu-Tzu Tai; Craig E Cole; Teru Hideshima; Martin Sattler; Angela Hamblin; Nicholas Mitsiades; Robert Schlossman; Faith E Davies; Gareth J Morgan; Nikhil C Munshi; Dharminder Chauhan; Kenneth C Anderson
Essential role of caveolae in interleukin-6- and insulin-like growth factor I-triggered Akt-1-mediated survival of multiple myeloma cells.
The Journal of biological chemistry 2003;278(8):5794-801.
2003: Teru Hideshima; Constantine S Mitsiades; Masaharu Akiyama; Toshiaki Hayashi; Dharminder Chauhan; Paul Richardson; Robert Schlossman; klaus podar; Nikhil C Munshi; Nicholas Mitsiades; Kenneth C Anderson
Molecular mechanisms mediating antimyeloma activity of proteasome inhibitor PS-341.
Blood 2003;101(4):1530-4.
2003: Teru Hideshima; Masaharu Akiyama; Toshiaki Hayashi; Paul Richardson; Robert Schlossman; Dharminder Chauhan; Kenneth C Anderson
Targeting p38 MAPK inhibits multiple myeloma cell growth in the bone marrow milieu.
Blood 2003;101(2):703-5.
2003: Masaharu Akiyama; Teru Hideshima; Toshiaki Hayashi; Yu-Tzu Tai; Constantine S Mitsiades; Nicholas Mitsiades; Dharminder Chauhan; Paul Richardson; Nikhil C Munshi; Kenneth C Anderson
Nuclear factor-kappaB p65 mediates tumor necrosis factor alpha-induced nuclear translocation of telomerase reverse transcriptase protein.
Cancer research 2003;63(1):18-21.
2002: Toru Yamaguchi; Mika Yamauchi; Toshitsugu Sugimoto; Dharminder Chauhan; Kenneth C Anderson; Edward M Brown; Kazuo Chihara
The extracellular calcium Ca2+o-sensing receptor is expressed in myeloma cells and modulates cell proliferation.
Biochemical and biophysical research communications 2002;299(4):532-8.
2002: Paul G Richardson; Robert Schlossman; Edie Weller; Teru Hideshima; Constantine S Mitsiades; Faith Davies; Richard LeBlanc; Laurence Catley; Deborah Doss; Kathleen Kelly; Mary McKenney; Julie Mechlowicz; Andrea Freeman; Reggie Deocampo; Rebecca Rich; Joan J Ryoo; Dharminder Chauhan; Kathe Balinski; Jerome B Zeldis; Kenneth C Anderson
Immunomodulatory drug CC-5013 overcomes drug resistance and is well tolerated in patients with relapsed multiple myeloma.
Blood 2002;100(9):3063-7.
2002: Nicholas Mitsiades; Constantine S Mitsiades; Vassiliki Poulaki; Dharminder Chauhan; Galinos Fanourakis; Xuesong Gu; Charles Bailey; Marie Joseph; Towia Libermann; Steve P Treon; Nikhil C Munshi; Paul G Richardson; Teru Hideshima; Kenneth C Anderson
Molecular sequelae of proteasome inhibition in human multiple myeloma cells.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(22):14374-9.
2002: Dharminder Chauhan; Laurence Catley; Teru Hideshima; Guilan Li; Richard LeBlanc; Deepak Gupta; Martin Sattler; Paul Richardson; Robert Schlossman; klaus podar; Edie Weller; Nikhil C Munshi; Kenneth C Anderson
2-Methoxyestradiol overcomes drug resistance in multiple myeloma cells.
Blood 2002;100(6):2187-94.
2002: Constantine S Mitsiades; Nicholas Mitsiades; Vassiliki Poulaki; Robert Schlossman; Masaharu Akiyama; Dharminder Chauhan; Teru Hideshima; Steve P Treon; Nikhil C Munshi; Paul G Richardson; Kenneth C Anderson
Activation of NF-kappaB and upregulation of intracellular anti-apoptotic proteins via the IGF-1/Akt signaling in human multiple myeloma cells: therapeutic implications.
Oncogene 2002;21(37):5673-83.
2002: Toshiaki Hayashi; Teru Hideshima; Masaharu Akiyama; Paul Richardson; Robert Schlossman; Dharminder Chauhan; Nikhil C Munshi; Samuel Waxman; Kenneth C Anderson
Arsenic trioxide inhibits growth of human multiple myeloma cells in the bone marrow microenvironment.
Molecular cancer therapeutics 2002;1(10):851-60.
2002: Nikhil C Munshi; Teru Hideshima; Dharminder Chauhan; Paul G Richardson; Kenneth C Anderson
Novel biologically based therapies for multiple myeloma.
International journal of hematology 2002;76 Suppl 1():340-1.
2002: Deepak Gupta; klaus podar; Yu-Tzu Tai; Boris Lin; Teru Hideshima; Masaharu Akiyama; Richard LeBlanc; Laurence Catley; Nicholas Mitsiades; Constantine S Mitsiades; Dharminder Chauhan; Nikhil C Munshi; Kenneth C Anderson
beta-lapachone, a novel plant product, overcomes drug resistance in human multiple myeloma cells.
Experimental hematology 2002;30(7):711-20.
2002: Masaharu Akiyama; Teru Hideshima; Toshiaki Hayashi; Yu-Tzu Tai; Constantine S Mitsiades; Nicholas Mitsiades; Dharminder Chauhan; Paul Richardson; Nikhil C Munshi; Kenneth C Anderson
Cytokines modulate telomerase activity in a human multiple myeloma cell line.
Cancer research 2002;62(13):3876-82.
2002: Nicholas Mitsiades; Constantine S Mitsiades; Vassiliki Poulaki; Dharminder Chauhan; Paul G Richardson; Teru Hideshima; Nikhil C Munshi; Steve P Treon; Kenneth C Anderson
Apoptotic signaling induced by immunomodulatory thalidomide analogs in human multiple myeloma cells: therapeutic implications.
Blood 2002;99(12):4525-30.
2002: Nicholas Mitsiades; Constantine S Mitsiades; Vassiliki Poulaki; Dharminder Chauhan; Paul G Richardson; Teru Hideshima; Nikhil C Munshi; Steve P Treon; Kenneth C Anderson
Biologic sequelae of nuclear factor-kappaB blockade in multiple myeloma: therapeutic applications.
Blood 2002;99(11):4079-86.
2002: Teru Hideshima; Dharminder Chauhan; Paul Richardson; Constantine S Mitsiades; Nicholas Mitsiades; Toshiaki Hayashi; Nikhil C Munshi; Lenny Dang; Alfredo Castro; Vito J Palombella; Julian Adams; Kenneth C Anderson
NF-kappa B as a therapeutic target in multiple myeloma.
The Journal of biological chemistry 2002;277(19):16639-47.
2002: Teru Hideshima; Dharminder Chauhan; Toshiaki Hayashi; klaus podar; Masaharu Akiyama; Deepak Gupta; Paul Richardson; Nikhil C Munshi; Kenneth C Anderson
The biological sequelae of stromal cell-derived factor-1alpha in multiple myeloma.
Molecular cancer therapeutics 2002;1(7):539-44.
2002: klaus podar; Yu-Tzu Tai; Boris K Lin; Radha P Narsimhan; Martin Sattler; Takashi Kijima; Ravi Salgia; Deepak Gupta; Dharminder Chauhan; Kenneth C Anderson
Vascular endothelial growth factor-induced migration of multiple myeloma cells is associated with beta 1 integrin- and phosphatidylinositol 3-kinase-dependent PKC alpha activation.
The Journal of biological chemistry 2002;277(10):7875-81.
2002: Igor Semenov; Canan Akyuz; Vera Roginskaya; Dharminder Chauhan; Seth J Corey
Growth inhibition and apoptosis of myeloma cells by the CDK inhibitor flavopiridol.
Leukemia research 2002;26(3):271-80.
2002: Dharminder Chauhan; Daniel Auclair; Elisabeth K Robinson; Teru Hideshima; Guilan Li; klaus podar; Deepak Gupta; Paul Richardson; Robert Schlossman; Nancy L Krett; Lan Bo Chen; Nikhil C Munshi; Kenneth C Anderson
Identification of genes regulated by dexamethasone in multiple myeloma cells using oligonucleotide arrays.
Oncogene 2002;21(9):1346-58.
2001: Deepak Gupta; Steve P Treon; Y Shima; Teru Hideshima; klaus podar; Yu-Tzu Tai; Boris Lin; Suzanne Lentzsch; Faith E Davies; Dharminder Chauhan; Robert Schlossman; Paul Richardson; P Ralph; Lei Wu; Faribourz Payvandi; G Muller; David I Stirling; Kenneth C Anderson
Adherence of multiple myeloma cells to bone marrow stromal cells upregulates vascular endothelial growth factor secretion: therapeutic applications.
Leukemia 2001;15(12):1950-61.
2001: Teru Hideshima; Dharminder Chauhan; klaus podar; Robert Schlossman; Paul Richardson; Kenneth C Anderson
Novel therapies targeting the myeloma cell and its bone marrow microenvironment.
Seminars in oncology 2001;28(6):607-12.
2001: Teru Hideshima; N Nakamura; Dharminder Chauhan; Kenneth C Anderson
Biologic sequelae of interleukin-6 induced PI3-K/Akt signaling in multiple myeloma.
Oncogene 2001;20(42):5991-6000.
2001: Teru Hideshima; Dharminder Chauhan; Robert Schlossman; Paul Richardson; Kenneth C Anderson
The role of tumor necrosis factor alpha in the pathophysiology of human multiple myeloma: therapeutic applications.
Oncogene 2001;20(33):4519-27.
2001: klaus podar; Yu-Tzu Tai; Faith E Davies; Suzanne Lentzsch; Martin Sattler; Teru Hideshima; Boris K Lin; Deepak Gupta; Y Shima; Dharminder Chauhan; Constantine S Mitsiades; Noopur Raje; Paul Richardson; Kenneth C Anderson
Vascular endothelial growth factor triggers signaling cascades mediating multiple myeloma cell growth and migration.
Blood 2001;98(2):428-35.
2001: Dharminder Chauhan; Teru Hideshima; S Rosen; J C Reed; S Kharbanda; Kenneth C Anderson
Apaf-1/cytochrome c-independent and Smac-dependent induction of apoptosis in multiple myeloma (MM) cells.
The Journal of biological chemistry 2001;276(27):24453-6.
2001: Faith E Davies; Noopur Raje; Teru Hideshima; Suzanne Lentzsch; Gloria Young; Yu-Tzu Tai; Boris Lin; klaus podar; Deepak Gupta; Dharminder Chauhan; Steve P Treon; Paul G Richardson; Robert Schlossman; G J Morgan; George W Muller; David I Stirling; Kenneth C Anderson
Thalidomide and immunomodulatory derivatives augment natural killer cell cytotoxicity in multiple myeloma.
Blood 2001;98(1):210-6.
2001: Teru Hideshima; Paul Richardson; Dharminder Chauhan; Vito J Palombella; Peter J Elliott; Julian Adams; Kenneth C Anderson
The proteasome inhibitor PS-341 inhibits growth, induces apoptosis, and overcomes drug resistance in human multiple myeloma cells.
Cancer research 2001;61(7):3071-6.
2001: Dharminder Chauhan; Kenneth C Anderson
Apoptosis in multiple myeloma: therapeutic implications.
Apoptosis : an international journal on programmed cell death 2001;6(1-2):47-55.
2000: Yu-Tzu Tai; G Teoh; Boris Lin; FE Davies; Dharminder Chauhan; Steve P Treon; Noopur Raje; Teru Hideshima; Y Shima; klaus podar; Kenneth C Anderson
Ku86 variant expression and function in multiple myeloma cells is associated with increased sensitivity to DNA damage.
Journal of immunology (Baltimore, Md. : 1950) 2000;165(11):6347-55.
2000: Steve P Treon; P Maimonis; D Bua; Gloria Young; Noopur Raje; Joseph A Mollick; Dharminder Chauhan; Yu-Tzu Tai; Teru Hideshima; Y Shima; JH Hilgers; Silvia von Mensdorff-Pouilly; Andrew R Belch; Linda M Pilarski; Kenneth C Anderson
Elevated soluble MUC1 levels and decreased anti-MUC1 antibody levels in patients with multiple myeloma.
Blood 2000;96(9):3147-53.
2000: Teru Hideshima; Dharminder Chauhan; Y Shima; Noopur Raje; Faith E Davies; Yu-Tzu Tai; Steve P Treon; Boris Lin; Robert Schlossman; Paul Richardson; G Muller; David I Stirling; Kenneth C Anderson
Thalidomide and its analogs overcome drug resistance of human multiple myeloma cells to conventional therapy.
Blood 2000;96(9):2943-50.
2000: Dharminder Chauhan; Pramod Pandey; Teru Hideshima; Steve P Treon; Noopur Raje; Faith E Davies; Y Shima; Yu-Tzu Tai; S Rosen; S Avraham; Surender Kharbanda; Kenneth C Anderson
SHP2 mediates the protective effect of interleukin-6 against dexamethasone-induced apoptosis in multiple myeloma cells.
The Journal of biological chemistry 2000;275(36):27845-50.
2000: Noopur Raje; G Kica; Dharminder Chauhan; Yana Zhang; G Teoh; Steve P Treon; Teru Hideshima; Jian-Hong Deng; Shou-Jiang Gao; M Alsina; J Wally; FE Davies; Yu-Tzu Tai; Geraldine S Pinkus; Jack L Pinkus; Martha Skinner; Raymond Comenzo; Kenneth C Anderson
Kaposi's sarcoma-associated herpesvirus gene sequences are detectable at low copy number in primary amyloidosis.
Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis 2000;7(2):126-32.
2000: Teru Hideshima; Dharminder Chauhan; G Teoh; Noopur Raje; Steve P Treon; Yu-Tzu Tai; Y Shima; Kenneth C Anderson
Characterization of signaling cascades triggered by human interleukin-6 versus Kaposi's sarcoma-associated herpes virus-encoded viral interleukin 6.
Clinical cancer research : an official journal of the American Association for Cancer Research 2000;6(3):1180-9.
2000: Yu-Tzu Tai; G Teoh; Y Shima; Dharminder Chauhan; Steve P Treon; Noopur Raje; Teru Hideshima; FE Davies; Kenneth C Anderson
Isolation and characterization of human multiple myeloma cell enriched populations.
Journal of immunological methods 2000;235(1-2):11-9.
2000: G Teoh; Yu-Tzu Tai; Mitsuyoshi Urashima; S Shirahama; M Matsuzaki; Dharminder Chauhan; Steve P Treon; Noopur Raje; Teru Hideshima; Y Shima; Kenneth C Anderson
CD40 activation mediates p53-dependent cell cycle regulation in human multiple myeloma cell lines.
Blood 2000;95(3):1039-46.
1999: Dharminder Chauhan; Teru Hideshima; P Pandey; Steve P Treon; G Teoh; Noopur Raje; S Rosen; N Krett; H Husson; S Avraham; S Kharbanda; Kenneth C Anderson
RAFTK/PYK2-dependent and -independent apoptosis in multiple myeloma cells.
Oncogene 1999;18(48):6733-40.
1999: Dharminder Chauhan; Teru Hideshima; Steve P Treon; G Teoh; Noopur Raje; S Yoshihimito; Yu-Tzu Tai; W Li; J Fan; James A DeCaprio; Kenneth C Anderson
Functional interaction between retinoblastoma protein and stress-activated protein kinase in multiple myeloma cells.
Cancer research 1999;59(6):1192-5.
1999: Noopur Raje; J Gong; Dharminder Chauhan; G Teoh; David Avigan; Z Wu; D Chen; Steve P Treon; Iain Webb; Donald Kufe; Kenneth C Anderson
Bone marrow and peripheral blood dendritic cells from patients with multiple myeloma are phenotypically and functionally normal despite the detection of Kaposi's sarcoma herpesvirus gene sequences.
Blood 1999;93(5):1487-95.
1999: Dharminder Chauhan; A Bharti; Noopur Raje; EA Gustafson; Geraldine S Pinkus; Jack L Pinkus; G Teoh; Teru Hideshima; Steve P Treon; Joyce Diane Fingeroth; Kenneth C Anderson
Detection of Kaposi's sarcoma herpesvirus DNA sequences in multiple myeloma bone marrow stromal cells.
Blood 1999;93(5):1482-6.
1999: Steve P Treon; Joseph A Mollick; Mitsuyoshi Urashima; G Teoh; Dharminder Chauhan; A Ogata; Noopur Raje; JH Hilgers; Lee M Nadler; Andrew R Belch; Linda M Pilarski; Kenneth C Anderson
Muc-1 core protein is expressed on multiple myeloma cells and is induced by dexamethasone.
Blood 1999;93(4):1287-98.
1998: G Teoh; L Chen; Mitsuyoshi Urashima; Yu-Tzu Tai; L A Celi; D Chen; Dharminder Chauhan; A Ogata; Robert W Finberg; Iain Webb; Donald Kufe; Kenneth C Anderson
Adenovirus vector-based purging of multiple myeloma cells.
Blood 1998;92(12):4591-601.
1998: Steve P Treon; G Teoh; Mitsuyoshi Urashima; A Ogata; Dharminder Chauhan; Iain Webb; Kenneth C Anderson
Anti-estrogens induce apoptosis of multiple myeloma cells.
Blood 1998;92(5):1749-57.
1998: G Teoh; Mitsuyoshi Urashima; Edward Greenfield; K A Nguyen; J F Lee; Dharminder Chauhan; A Ogata; Steve P Treon; Kenneth C Anderson
The 86-kD subunit of Ku autoantigen mediates homotypic and heterotypic adhesion of multiple myeloma cells.
The Journal of clinical investigation 1998;101(6):1379-88.
1997: Mitsuyoshi Urashima; James A DeCaprio; Dharminder Chauhan; G Teoh; A Ogata; Steve P Treon; Y Hoshi; Kenneth C Anderson
p16INK4A promotes differentiation and inhibits apoptosis of JKB acute lymphoblastic leukemia cells.
Blood 1997;90(10):4106-15.
1997: Mitsuyoshi Urashima; G Teoh; A Ogata; Dharminder Chauhan; Steve P Treon; Y Sugimoto; C Kaihara; M Matsuzaki; Y Hoshi; James A DeCaprio; Kenneth C Anderson
Characterization of p16(INK4A) expression in multiple myeloma and plasma cell leukemia.
Clinical cancer research : an official journal of the American Association for Cancer Research 1997;3(11):2173-9.
1997: G Teoh; Mitsuyoshi Urashima; A Ogata; Dharminder Chauhan; James A DeCaprio; Steve P Treon; Robert Schlossman; Kenneth C Anderson
MDM2 protein overexpression promotes proliferation and survival of multiple myeloma cells.
Blood 1997;90(5):1982-92.
1997: A Ogata; Dharminder Chauhan; Mitsuyoshi Urashima; G Teoh; Steve P Treon; Kenneth C Anderson
Blockade of mitogen-activated protein kinase cascade signaling in interleukin 6-independent multiple myeloma cells.
Clinical cancer research : an official journal of the American Association for Cancer Research 1997;3(6):1017-22.
1997: Dharminder Chauhan; S Kharbanda; A Ogata; Mitsuyoshi Urashima; G Teoh; M Robertson; Donald Kufe; Kenneth C Anderson
Interleukin-6 inhibits Fas-induced apoptosis and stress-activated protein kinase activation in multiple myeloma cells.
Blood 1997;89(1):227-34.
1996: Mitsuyoshi Urashima; Y Hoshi; Y Sugimoto; C Kaihara; M Matsuzaki; Dharminder Chauhan; A Ogata; G Teoh; James A DeCaprio; Kenneth C Anderson
A novel pre-B acute lymphoblastic leukemia cell line with chromosomal translocation between p16(INK4A)/p15(INK4B) tumor suppressor and immunoglobulin heavy chain genes: TGFbeta/IL-7 inhibitory signaling mechanism.
Leukemia 1996;10(10):1576-83.
1996: Mitsuyoshi Urashima; A Ogata; Dharminder Chauhan; M B Vidriales; G Teoh; Y Hoshi; Robert Schlossman; James A DeCaprio; Kenneth C Anderson
Interleukin-6 promotes multiple myeloma cell growth via phosphorylation of retinoblastoma protein.
Blood 1996;88(6):2219-27.
1996: D A Dedera; Mitsuyoshi Urashima; Dharminder Chauhan; D P LeBrun; R T Bronson; Kenneth C Anderson
Interleukin-6 is required for pristane-induced plasma cell hyperplasia in mice.
British journal of haematology 1996;94(1):53-61.
1996: Mitsuyoshi Urashima; Dharminder Chauhan; M Hatziyanni; A Ogata; D Hollenbaugh; A Aruffo; Kenneth C Anderson
CD40 ligand triggers interleukin-6 mediated B cell differentiation.
Leukemia research 1996;20(6):507-15.
1996: Mitsuyoshi Urashima; A Ogata; Dharminder Chauhan; M Hatziyanni; M B Vidriales; D A Dedera; Robert Schlossman; Kenneth C Anderson
Transforming growth factor-beta1: differential effects on multiple myeloma versus normal B cells.
Blood 1996;87(5):1928-38.
1996: Dharminder Chauhan; H Uchiyama; Yasmin Akbarali; Mitsuyoshi Urashima; K Yamamoto; Towia Libermann; Kenneth C Anderson
Multiple myeloma cell adhesion-induced interleukin-6 expression in bone marrow stromal cells involves activation of NF-kappa B.
Blood 1996;87(3):1104-12.
1995: Dharminder Chauhan; S M Kharbanda; A Ogata; Mitsuyoshi Urashima; D Frank; N Malik; Donald Kufe; Kenneth C Anderson
Oncostatin M induces association of Grb2 with Janus kinase JAK2 in multiple myeloma cells.
The Journal of experimental medicine 1995;182(6):1801-6.
1995: Dharminder Chauhan; H Uchiyama; Mitsuyoshi Urashima; K Yamamoto; Kenneth C Anderson
Regulation of interleukin 6 in multiple myeloma and bone marrow stromal cells.
Stem cells (Dayton, Ohio) 1995;13 Suppl 2():35-9.
1995: Dharminder Chauhan; S M Kharbanda; H Uchiyama; Mitsuyoshi Urashima; Kenneth C Anderson
Activation of pp90rsk and early growth response-1 gene expression by pokeweed mitogen in human B cells.
Leukemia research 1995;19(5):337-44.
1995: Mitsuyoshi Urashima; Dharminder Chauhan; H Uchiyama; Gordon J Freeman; Kenneth C Anderson
CD40 ligand triggered interleukin-6 secretion in multiple myeloma.
Blood 1995;85(7):1903-12.
1994: Dharminder Chauhan; S Kharbanda; H Uchiyama; Mitsuyoshi Urashima; Ruben Fragoso; Jyoti Misra Sen; Donald Kufe; Kenneth C Anderson
Identification of upstream signals regulating interleukin-6 gene expression during in vitro treatment of human B cells with pokeweed mitogen.
Blood 1994;84(7):2243-52.
1994: I Kim; H Uchiyama; Dharminder Chauhan; Kenneth C Anderson
Cell surface expression and functional significance of adhesion molecules on human myeloma-derived cell lines.
British journal of haematology 1994;87(3):483-93.
1994: Dharminder Chauhan; S M Kharbanda; H Uchiyama; V P Sukhatme; Donald Kufe; Kenneth C Anderson
Involvement of serum response element in okadaic acid-induced EGR-1 transcription in human T-cells.
Cancer research 1994;54(8):2234-9.
1993: H Uchiyama; B A Barut; A F Mohrbacher; Dharminder Chauhan; Kenneth C Anderson
Adhesion of human myeloma-derived cell lines to bone marrow stromal cells stimulates interleukin-6 secretion.
Blood 1993;82(12):3712-20.
1993: B Barut; Dharminder Chauhan; H Uchiyama; Kenneth C Anderson
Interleukin-6 functions as an intracellular growth factor in hairy cell leukemia in vitro.
The Journal of clinical investigation 1993;92(5):2346-52.
1993: Dharminder Chauhan; S M Kharbanda; E Rubin; B A Barut; A Mohrbacher; Donald Kufe; Kenneth C Anderson
Regulation of c-jun gene expression in human T lymphocytes.
Blood 1993;81(6):1540-8.
1992: Kenneth C Anderson; Chikao Morimoto; S R Paul; Dharminder Chauhan; D Williams; M Cochran; B A Barut
Interleukin-11 promotes accessory cell-dependent B-cell differentiation in humans.
Blood 1992;80(11):2797-804.
1992: H Uchiyama; B A Barut; Dharminder Chauhan; Stephen A Cannistra; Kenneth C Anderson
Characterization of adhesion molecules on human myeloma cell lines.
Blood 1992;80(9):2306-14.
1992: B A Barut; L I Zon; M K Cochran; S R Paul; Dharminder Chauhan; A Mohrbacher; Joyce Diane Fingeroth; Kenneth C Anderson
Role of interleukin 6 in the growth of myeloma-derived cell lines.
Leukemia research 1992;16(10):951-9.