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Dharminder Chauhan
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171
Anderson, Kenneth
132
Hideshima, Teru
74
Munshi, Nikhil
69
podar, klaus
53
Mitsiades, Constantine
50
Tai, Yu-Tzu
46
Raje, Noopur
43
Richardson, Paul
32
Treon, Steve
32
Mitsiades, Nicholas
28
Catley, Laurence
28
Richardson, Paul
27
Schlossman, Robert
21
Urashima, Mitsuyoshi
20
Teoh, G
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All Publications
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2009: Negri Joseph M; McMillin Douglas W; Delmore Jake; Mitsiades Nicholas; Hayden Patrick; Klippel Steffen; Hideshima Teru; Chauhan Dharminder; Munshi Nikhil C; Buser Carolyn A; Pollard John; Richardson Paul G; Anderson Kenneth C; Mitsiades Constantine S
In vitro anti-myeloma activity of the Aurora kinase inhibitor VE-465.
British journal of haematology 2009;147(5):672-6.
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2009: Laubach Jacob P; Mitsiades Constantine S; Mahindra Anuj; Schlossman Robert L; Hideshima Teru; Chauhan Dharminder; Carreau Nicole A; Ghobrial Irene M; Raje Noopur; Munshi Nikhil C; Anderson Kenneth C; Richardson Paul G
Novel therapies in the treatment of multiple myeloma.
Journal of the National Comprehensive Cancer Network : JNCCN 2009;7(9):947-60.
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2009: Chauhan Dharminder; Singh Ajita V; Brahmandam Mohan; Carrasco Ruben; Bandi Madhavi; Hideshima Teru; Bianchi Giada; Podar Klaus; Tai Yu-Tzu; Mitsiades Constantine; Raje Noopur; Jaye David L; Kumar Shaji K; Richardson Paul; Munshi Nikhil; Anderson Kenneth C
Functional interaction of plasmacytoid dendritic cells with multiple myeloma cells: a therapeutic target.
Cancer cell 2009;16(4):309-23.
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2009: Hideshima Teru; Ikeda Hiroshi; Chauhan Dharminder; Okawa Yutaka; Raje Noopur; Podar Klaus; Mitsiades Constantine; Munshi Nikhil C; Richardson Paul G; Carrasco Ruben D; Anderson Kenneth C
Bortezomib induces canonical nuclear factor-kappaB activation in multiple myeloma cells.
Blood 2009;114(5):1046-52.
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2009: Fulciniti Mariateresa; Tassone Pierfrancesco; Hideshima Teru; Vallet Sonia; Nanjappa Puru; Ettenberg Seth A; Shen Zhenxin; Patel Nipun; Tai Yu-Tzu; Chauhan Dharminder; Mitsiades Constantine; Prabhala Rao; Raje Noopur; Anderson Kenneth C; Stover David R; Munshi Nikhil C
Anti-DKK1 mAb (BHQ880) as a potential therapeutic agent for multiple myeloma.
Blood 2009;114(2):371-9.
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2009: Zhang Jing; Sattler Martin; Tonon Giovanni; Grabher Clemens; Lababidi Samir; Zimmerhackl Alexander; Raab Marc S; Vallet Sonia; Zhou Yiming; Cartron Marie-Astrid; Hideshima Teru; Tai Yu-Tzu; Chauhan Dharminder; Anderson Kenneth C; Podar Klaus
Targeting angiogenesis via a c-Myc/hypoxia-inducible factor-1alpha-dependent pathway in multiple myeloma.
Cancer research 2009;69(12):5082-90.
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2009: Hideshima Teru; Chauhan Dharminder; Kiziltepe Tanyel; Ikeda Hiroshi; Okawa Yutaka; Podar Klaus; Raje Noopur; Protopopov Alexei; Munshi Nikhil C; Richardson Paul G; Carrasco Ruben D; Anderson Kenneth C
Biologic sequelae of I{kappa}B kinase (IKK) inhibition in multiple myeloma: therapeutic implications.
Blood 2009;113(21):5228-36.
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2009: Mitsiades Constantine S; Hideshima Teru; Chauhan Dharminder; McMillin Douglas W; Klippel Steffen; Laubach Jacob P; Munshi Nikhil C; Anderson Kenneth C; Richardson Paul G
Emerging treatments for multiple myeloma: beyond immunomodulatory drugs and bortezomib.
Seminars in hematology 2009;46(2):166-75.
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2009: Raab Marc S; Breitkreutz Iris; Tonon Giovanni; Zhang Jing; Hayden Patrick J; Nguyen Thu; Fruehauf Johannes H; Lin Boris K; Chauhan Dharminder; Hideshima Teru; Munshi Nikhil C; Anderson Kenneth C; Podar Klaus
Targeting PKC: a novel role for beta-catenin in ER stress and apoptotic signaling.
Blood 2009;113(7):1513-21.
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2009: Burger Renate; Le Gouill Steven; Tai Yu-Tzu; Shringarpure Reshma; Tassone Pierfrancesco; Neri Paola; Podar Klaus; Catley Laurence; Hideshima Teru; Chauhan Dharminder; Caulder Eian; Neilan Claire L; Vaddi Kris; Li Jun; Gramatzki Martin; Fridman Jordan S; Anderson Kenneth C
Janus kinase inhibitor INCB20 has antiproliferative and apoptotic effects on human myeloma cells in vitro and in vivo.
Molecular cancer therapeutics 2009;8(1):26-35.
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2008: Nelson Erik A; Walker Sarah R; Kepich Alicia; Gashin Laurie B; Hideshima Teru; Ikeda Hiroshi; Chauhan Dharminder; Anderson Kenneth C; Frank David A
Nifuroxazide inhibits survival of multiple myeloma cells by directly inhibiting STAT3.
Blood 2008;112(13):5095-102.
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2008: Mitsiades Constantine S; Ocio Enrique M; Pandiella Atanasio; Maiso Patricia; Gajate Consuelo; Garayoa Mercedes; Vilanova David; Montero Juan Carlos; Mitsiades Nicholas; McMullan Ciaran J; Munshi Nikhil C; Hideshima Teru; Chauhan Dharminder; Aviles Pablo; Otero Gabriel; Faircloth Glynn; Mateos M Victoria; Richardson Paul G; Mollinedo Faustino; San-Miguel Jesus F; Anderson Kenneth C
Aplidin, a marine organism-derived compound with potent antimyeloma activity in vitro and in vivo.
Cancer research 2008;68(13):5216-25.
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2008: Ishitsuka Kenji; Hideshima Teru; Neri Paola; Vallet Sonia; Shiraishi Norihiko; Okawa Yutaka; Shen Zhenxin; Raje Noopur; Kiziltepe Tanyel; Ocio Enrique M; Chauhan Dharminder; Tassone Pierfrancesco; Munshi Nikhil; Campbell Robert M; Dios Alfonso De; Shih Chuan; Starling James J; Tamura Kazuo; Anderson Kenneth C
p38 mitogen-activated protein kinase inhibitor LY2228820 enhances bortezomib-induced cytotoxicity and inhibits osteoclastogenesis in multiple myeloma; therapeutic implications.
British journal of haematology 2008;141(5):598-606.
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2008: Roccaro Aldo M; Leleu Xavier; Sacco Antonio; Jia Xiaoying; Melhem Molly; Moreau Anne-Sophie; Ngo Hai T; Runnels Judith; Azab Abdelkareem; Azab Feda; Burwick Nicholas; Farag Mena; Treon Steven P; Palladino Michael A; Hideshima Teru; Chauhan Dharminder; Anderson Kenneth C; Ghobrial Irene M
Dual targeting of the proteasome regulates survival and homing in Waldenstrom macroglobulinemia.
Blood 2008;111(9):4752-63.
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2008: Chauhan Dharminder; Singh Ajita; Brahmandam Mohan; Podar Klaus; Hideshima Teru; Richardson Paul; Munshi Nikhil; Palladino Michael A; Anderson Kenneth C
Combination of proteasome inhibitors bortezomib and NPI-0052 trigger in vivo synergistic cytotoxicity in multiple myeloma.
Blood 2008;111(3):1654-64.
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2008: Podar K; Gouill S L; Zhang J; Opferman J T; Zorn E; Tai Y-T; Hideshima T; Amiot M; Chauhan D; Harousseau J-L; Anderson K C
A pivotal role for Mcl-1 in Bortezomib-induced apoptosis.
Oncogene 2008;27(6):721-31.
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2008: Chauhan Dharminder; Bianchi Giada; Anderson Kenneth C
Targeting the UPS as therapy in multiple myeloma.
BMC biochemistry 2008;9 Suppl 1():S1.
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2008: Chauhan Dharminder; Hideshima Teru; Anderson Kenneth C
Targeting proteasomes as therapy in multiple myeloma.
Advances in experimental medicine and biology 2008;615():251-60.
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2007: Podar Klaus; Richardson Paul G; Hideshima Teru; Chauhan Dharminder; Anderson Kenneth C
The malignant clone and the bone-marrow environment.
Best practice & research. Clinical haematology 2007;20(4):597-612.
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2007: Mitsiades Constantine S; McMillin Douglas W; Klippel Steffen; Hideshima Teru; Chauhan Dharminder; Richardson Paul G; Munshi Nikhil C; Anderson Kenneth C
The role of the bone marrow microenvironment in the pathophysiology of myeloma and its significance in the development of more effective therapies.
Hematology/oncology clinics of North America 2007;21(6):1007-34, vii-viii.
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2007: Neri P; Tassone P; Shammas M; Yasui H; Schipani E; Batchu R B; Blotta S; Prabhala R; Catley L; Hamasaki M; Hideshima T; Chauhan D; Jacob G S; Picker D; Venuta S; Anderson K C; Munshi N C
Biological pathways and in vivo antitumor activity induced by Atiprimod in myeloma.
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 2007;21(12):2519-26.
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2007: Podar Klaus; Raab Marc S; Chauhan Dharminder; Anderson Kenneth C
The therapeutic role of targeting protein kinase C in solid and hematologic malignancies.
Expert opinion on investigational drugs 2007;16(10):1693-707.
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2007: Neri Paola; Kumar Shaji; Fulciniti Maria Teresa; Vallet Sonia; Chhetri Shweta; Mukherjee Sidhartha; Tai Yutzu; Chauhan Dharminder; Tassone Pierfrancesco; Venuta Salvatore; Munshi Nikhil C; Hideshima Teru; Anderson Kenneth C; Raje Noopur
Neutralizing B-cell activating factor antibody improves survival and inhibits osteoclastogenesis in a severe combined immunodeficient human multiple myeloma model.
Clinical cancer research : an official journal of the American Association for Cancer Research 2007;13(19):5903-9.
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2007: Breitkreutz Iris; Raab Marc S; Vallet Sonia; Hideshima Teru; Raje Noopur; Chauhan Dharminder; Munshi Nikhil C; Richardson Paul G; Anderson Kenneth C
Targeting MEK1/2 blocks osteoclast differentiation, function and cytokine secretion in multiple myeloma.
British journal of haematology 2007;139(1):55-63.
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2007: Hideshima Teru; Catley Laurence; Raje Noopur; Chauhan Dharminder; Podar Klaus; Mitsiades Constantine; Tai Yu-Tzu; Vallet Sonia; Kiziltepe Tanyel; Ocio Enrique; Ikeda Hiroshi; Okawa Yutaka; Hideshima Hiromasa; Munshi Nikhil C; Yasui Hiroshi; Richardson Paul G; Anderson Kenneth C
Inhibition of Akt induces significant downregulation of survivin and cytotoxicity in human multiple myeloma cells.
British journal of haematology 2007;138(6):783-91.
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2007: Tai Yu-Tzu; Fulciniti Mariateresa; Hideshima Teru; Song Weihua; Leiba Merav; Li Xian-Feng; Rumizen Matthew; Burger Peter; Morrison Aileen; Podar Klaus; Chauhan Dharminder; Tassone Pierfrancesco; Richardson Paul; Munshi Nikhil C; Ghobrial Irene M; Anderson Kenneth C
Targeting MEK induces myeloma-cell cytotoxicity and inhibits osteoclastogenesis.
Blood 2007;110(5):1656-63.
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2007: Catley Laurence; Hideshima Teru; Chauhan Dharminder; Neri Paola; Tassone Pierfrancesco; Bronson Roderick; Song Weihua; Tai Yu-Tzu; Munshi Nikhil C; Anderson Kenneth C
Alkyl phospholipid perifosine induces myeloid hyperplasia in a murine myeloma model.
Experimental hematology 2007;35(7):1038-46.
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2007: Kiziltepe Tanyel; Hideshima Teru; Ishitsuka Kenji; Ocio Enrique M; Raje Noopur; Catley Laurence; Li Chun-Qi; Trudel Laura J; Yasui Hiroshi; Vallet Sonia; Kutok Jeffery L; Chauhan Dharminder; Mitsiades Constantine S; Saavedra Joseph E; Wogan Gerald N; Keefer Larry K; Shami Paul J; Anderson Kenneth C
JS-K, a GST-activated nitric oxide generator, induces DNA double-strand breaks, activates DNA damage response pathways, and induces apoptosis in vitro and in vivo in human multiple myeloma cells.
Blood 2007;110(2):709-18.
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2007: Kiziltepe Tanyel; Hideshima Teru; Catley Laurence; Raje Noopur; Yasui Hiroshi; Shiraishi Norihiko; Okawa Yutaka; Ikeda Hiroshi; Vallet Sonia; Pozzi Samantha; Ishitsuka Kenji; Ocio Enrique M; Chauhan Dharminder; Anderson Kenneth C
5-Azacytidine, a DNA methyltransferase inhibitor, induces ATR-mediated DNA double-strand break responses, apoptosis, and synergistic cytotoxicity with doxorubicin and bortezomib against multiple myeloma cells.
Molecular cancer therapeutics 2007;6(6):1718-27.
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2007: Podar Klaus; Richardson Paul G; Chauhan Dharminder; Anderson Kenneth C
Targeting the vascular endothelial growth factor pathway in the treatment of multiple myeloma.
Expert review of anticancer therapy 2007;7(4):551-66.
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2007: Chauhan D; Velankar M; Brahmandam M; Hideshima T; Podar K; Richardson P; Schlossman R; Ghobrial I; Raje N; Munshi N; Anderson K C
A novel Bcl-2/Bcl-X(L)/Bcl-w inhibitor ABT-737 as therapy in multiple myeloma.
Oncogene 2007;26(16):2374-80.
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2007: Yasui H; Hideshima T; Ikeda H; Ocio E M; Kiziltepe T; Vallet S; Okawa Y; Neri P; Sukhdeo K; Podar K; Chauhan D; Richardson P G; Raje N; Carrasco D R; Anderson K C
Novel etodolac analog SDX-308 (CEP-18082) induces cytotoxicity in multiple myeloma cells associated with inhibition of beta-catenin/TCF pathway.
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 2007;21(3):535-40.
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2007: Podar Klaus; Raab Marc S; Tonon Giovanni; Sattler Martin; Barilà Daniela; Zhang Jing; Tai Yu-Tzu; Yasui Hiroshi; Raje Noopur; DePinho Ronald A; Hideshima Teru; Chauhan Dharminder; Anderson Kenneth C
Up-regulation of c-Jun inhibits proliferation and induces apoptosis via caspase-triggered c-Abl cleavage in human multiple myeloma.
Cancer research 2007;67(4):1680-8.
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2007: Chauhan Dharminder; Neri Paola; Velankar Mugdha; Podar Klaus; Hideshima Teru; Fulciniti Mariateresa; Tassone Pierfrancesco; Raje Noopur; Mitsiades Constantine; Mitsiades Nicholas; Richardson Paul; Zawel Leigh; Tran Mary; Munshi Nikhil; Anderson Kenneth C
Targeting mitochondrial factor Smac/DIABLO as therapy for multiple myeloma (MM).
Blood 2007;109(3):1220-7.
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2007: Podar Klaus; Raab Marc S; Zhang Jing; McMillin Douglas; Breitkreutz Iris; Tai Yu-Tzu; Lin Boris K; Munshi Nikhil; Hideshima Teru; Chauhan Dharminder; Anderson Kenneth C
Targeting PKC in multiple myeloma: in vitro and in vivo effects of the novel, orally available small-molecule inhibitor enzastaurin (LY317615.HCl).
Blood 2007;109(4):1669-77.
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2007: Richardson Paul; Mitsiades Constantine; Schlossman Robert; Ghobrial Irene; Hideshima Teru; Chauhan Dharminder; Munshi Nikhil; Anderson Kenneth
The treatment of relapsed and refractory multiple myeloma.
Hematology / the Education Program of the American Society of Hematology. American Society of Hematology. Education Program 2007;():317-23.
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2006: Podar Klaus; Tonon Giovanni; Sattler Martin; Tai Yu-Tzu; Legouill Steven; Yasui Hiroshi; Ishitsuka Kenji; Kumar Shaji; Kumar Rakesh; Pandite Lini N; Hideshima Teru; Chauhan Dharminder; Anderson Kenneth C
The small-molecule VEGF receptor inhibitor pazopanib (GW786034B) targets both tumor and endothelial cells in multiple myeloma.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(51):19478-83.
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2006: Catley Laurence; Weisberg Ellen; Kiziltepe Tanyel; Tai Yu-Tzu; Hideshima Teru; Neri Paola; Tassone Pierfrancesco; Atadja Peter; Chauhan Dharminder; Munshi Nikhil C; Anderson Kenneth C
Aggresome induction by proteasome inhibitor bortezomib and alpha-tubulin hyperacetylation by tubulin deacetylase (TDAC) inhibitor LBH589 are synergistic in myeloma cells.
Blood 2006;108(10):3441-9.
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2006: Chauhan D; Hideshima T; Anderson K C
A novel proteasome inhibitor NPI-0052 as an anticancer therapy.
British journal of cancer 2006;95(8):961-5.
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2006: Hideshima Teru; Neri Paola; Tassone Pierfranchesco; Yasui Hiroshi; Ishitsuka Kenji; Raje Noopur; Chauhan Dharminder; Podar Klaus; Mitsiades Constantine; Dang Lenny; Munshi Nikhil; Richardson Paul; Schenkein David; Anderson Kenneth C
MLN120B, a novel IkappaB kinase beta inhibitor, blocks multiple myeloma cell growth in vitro and in vivo.
Clinical cancer research : an official journal of the American Association for Cancer Research 2006;12(19):5887-94.
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2006: Shringarpure Reshma; Catley Laurence; Bhole Deepak; Burger Renate; Podar Klaus; Tai Yu-Tzu; Kessler Benedikt; Galardy Paul; Ploegh Hidde; Tassone Pierfrancesco; Hideshima Teru; Mitsiades Constantine; Munshi Nikhil C; Chauhan Dharminder; Anderson Kenneth C
Gene expression analysis of B-lymphoma cells resistant and sensitive to bortezomib.
British journal of haematology 2006;134(2):145-56.
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2006: Tai Yu-Tzu; Li Xian-Feng; Breitkreutz Iris; Song Weihua; Neri Paola; Catley Laurence; Podar Klaus; Hideshima Teru; Chauhan Dharminder; Raje Noopur; Schlossman Robert; Richardson Paul; Munshi Nikhil C; Anderson Kenneth C
Role of B-cell-activating factor in adhesion and growth of human multiple myeloma cells in the bone marrow microenvironment.
Cancer research 2006;66(13):6675-82.
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2006: Crawford Lisa J A; Walker Brian; Ovaa Huib; Chauhan Dharminder; Anderson Kenneth C; Morris Treen C M; Irvine Alexandra E
Comparative selectivity and specificity of the proteasome inhibitors BzLLLCOCHO, PS-341, and MG-132.
Cancer research 2006;66(12):6379-86.
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2006: Hideshima Teru; Catley Laurence; Yasui Hiroshi; Ishitsuka Kenji; Raje Noopur; Mitsiades Constantine; Podar Klaus; Munshi Nikhil C; Chauhan Dharminder; Richardson Paul G; Anderson Kenneth C
Perifosine, an oral bioactive novel alkylphospholipid, inhibits Akt and induces in vitro and in vivo cytotoxicity in human multiple myeloma cells.
Blood 2006;107(10):4053-62.
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2006: Kumar Shaji; Raje Noopur; Hideshima Teru; Ishitsuka Kenji; Podar Klaus; Le Gouille Steven; Chauhan Dharminder; Richardson Paul; Munshi Nikhil C; Anderson Kenneth
FQPD, a novel immunomodulatory drug, has significant in vitro activity in multiple myeloma.
British journal of haematology 2006;132(6):698-704.
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2006: Mitsiades Constantine S; Mitsiades Nicholas S; McMullan Ciaran J; Poulaki Vassiliki; Kung Andrew L; Davies Faith E; Morgan Gareth; Akiyama Masaharu; Shringarpure Reshma; Munshi Nikhil C; Richardson Paul G; Hideshima Teru; Chauhan Dharminder; Gu Xuesong; Bailey Charles; Joseph Marie; Libermann Towia A; Rosen Neal S; Anderson Kenneth C
Antimyeloma activity of heat shock protein-90 inhibition.
Blood 2006;107(3):1092-100.
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2006: Prabhala Rao H; Neri Paola; Bae Jooeun E; Tassone Pierfrancesco; Shammas Masood A; Allam Charles K; Daley John F; Chauhan Dharminder; Blanchard Elizabeth; Thatte Hemant S; Anderson Kenneth C; Munshi Nikhil C
Dysfunctional T regulatory cells in multiple myeloma.
Blood 2006;107(1):301-4.
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2005: Hideshima Teru; Bradner James E; Chauhan Dharminder; Anderson Kenneth C
Intracellular protein degradation and its therapeutic implications.
Clinical cancer research : an official journal of the American Association for Cancer Research 2005;11(24 Pt 1):8530-3.
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2005: Tai Yu-Tzu; Li Xian-Feng; Catley Laurence; Coffey Rory; Breitkreutz Iris; Bae Jooeun; Song Weihua; Podar Klaus; Hideshima Teru; Chauhan Dharminder; Schlossman Robert; Richardson Paul; Treon Steven P; Grewal Iqbal S; Munshi Nikhil C; Anderson Kenneth C
Immunomodulatory drug lenalidomide (CC-5013, IMiD3) augments anti-CD40 SGN-40-induced cytotoxicity in human multiple myeloma: clinical implications.
Cancer research 2005;65(24):11712-20.
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2005: Chauhan Dharminder; Catley Laurence; Li Guilan; Podar Klaus; Hideshima Teru; Velankar Mugdha; Mitsiades Constantine; Mitsiades Nicolas; Yasui Hiroshi; Letai Anthony; Ovaa Huib; Berkers Celia; Nicholson Benjamin; Chao Ta-Hsiang; Neuteboom Saskia T C; Richardson Paul; Palladino Michael A; Anderson Kenneth C
A novel orally active proteasome inhibitor induces apoptosis in multiple myeloma cells with mechanisms distinct from Bortezomib.
Cancer cell 2005;8(5):407-19.
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2005: Chauhan Dharminder; Li Guilan; Podar Klaus; Hideshima Teru; Neri Paola; He Deli; Mitsiades Nicholas; Richardson Paul; Chang Yan; Schindler Joanne; Carver Bradley; Anderson Kenneth C
A novel carbohydrate-based therapeutic GCS-100 overcomes bortezomib resistance and enhances dexamethasone-induced apoptosis in multiple myeloma cells.
Cancer research 2005;65(18):8350-8.
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2005: Hideshima Teru; Chauhan Dharminder; Richardson Paul; Anderson Kenneth C
Identification and validation of novel therapeutic targets for multiple myeloma.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2005;23(26):6345-50.
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2005: Ishitsuka Kenji; Hideshima Teru; Hamasaki Makoto; Raje Noopur; Kumar Shaji; Podar Klaus; Le Gouill Steven; Shiraishi Norihiko; Yasui Hiroshi; Roccaro Aldo M; Tai Yu-Zu; Chauhan Dharminder; Fram Robert; Tamura Kazuo; Jain Jugnu; Anderson Kenneth C
Novel inosine monophosphate dehydrogenase inhibitor VX-944 induces apoptosis in multiple myeloma cells primarily via caspase-independent AIF/Endo G pathway.
Oncogene 2005;24(38):5888-96.
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2005: Ishitsuka Kenji; Hideshima Teru; Hamasaki Makoto; Raje Noopur; Kumar Shaji; Hideshima Hiromasa; Shiraishi Norihiko; Yasui Hiroshi; Roccaro Aldo M; Richardson Paul; Podar Klaus; Le Gouill Steven; Chauhan Dharminder; Tamura Kazuo; Arbiser Jack; Anderson Kenneth C
Honokiol overcomes conventional drug resistance in human multiple myeloma by induction of caspase-dependent and -independent apoptosis.
Blood 2005;106(5):1794-800.
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2005: Yasui Hiroshi; Hideshima Teru; Raje Noopur; Roccaro Aldo M; Shiraishi Norihiko; Kumar Shaji; Hamasaki Makoto; Ishitsuka Kenji; Tai Yu-Tzu; Podar Klaus; Catley Laurence; Mitsiades Constantine S; Richardson Paul G; Albert Rainer; Brinkmann Volker; Chauhan Dharminder; Anderson Kenneth C
FTY720 induces apoptosis in multiple myeloma cells and overcomes drug resistance.
Cancer research 2005;65(16):7478-84.
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2005: Catley Laurence; Tai Yu-Tzu; Chauhan Dharminder; Anderson Kenneth C
Perspectives for combination therapy to overcome drug-resistant multiple myeloma.
Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy 2005;8(4):205-18.
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2005: Raje Noopur; Kumar Shaji; Hideshima Teru; Roccaro Aldo; Ishitsuka Kenji; Yasui Hiroshi; Shiraishi Norihiko; Chauhan Dharminder; Munshi Nikhil C; Green Simon R; Anderson Kenneth C
Seliciclib (CYC202 or R-roscovitine), a small-molecule cyclin-dependent kinase inhibitor, mediates activity via down-regulation of Mcl-1 in multiple myeloma.
Blood 2005;106(3):1042-7.
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2005: Yasui Hiroshi; Hideshima Teru; Hamasaki Makoto; Roccaro Aldo M; Shiraishi Norihiko; Kumar Shaji; Tassone Pierfrancesco; Ishitsuka Kenji; Raje Noopur; Tai Yu-Tzu; Podar Klaus; Chauhan Dharminder; Leoni Lorenzo M; Kanekal Sarath; Elliott Gary; Munshi Nikhil C; Anderson Kenneth C
SDX-101, the R-enantiomer of etodolac, induces cytotoxicity, overcomes drug resistance, and enhances the activity of dexamethasone in multiple myeloma.
Blood 2005;106(2):706-12.
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2005: Hideshima Teru; Bradner James E; Wong Jason; Chauhan Dharminder; Richardson Paul; Schreiber Stuart L; Anderson Kenneth C
Small-molecule inhibition of proteasome and aggresome function induces synergistic antitumor activity in multiple myeloma.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(24):8567-72.
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2005: Tassone Pierfrancesco; Neri Paola; Burger Renate; Savino Rocco; Shammas Masood; Catley Laurence; Podar Klaus; Chauhan Dharminder; Masciari Serena; Gozzini Antonella; Tagliaferri Pierosandro; Venuta Salvatore; Munshi Nikhil C; Anderson Kenneth C
Combination therapy with interleukin-6 receptor superantagonist Sant7 and dexamethasone induces antitumor effects in a novel SCID-hu In vivo model of human multiple myeloma.
Clinical cancer research : an official journal of the American Association for Cancer Research 2005;11(11):4251-8.
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2005: Podar Klaus; Hideshima Teru; Chauhan Dharminder; Anderson Kenneth C
Targeting signalling pathways for the treatment of multiple myeloma.
Expert opinion on therapeutic targets 2005;9(2):359-81.
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2005: Chauhan Dharminder; Hideshima Teru; Mitsiades Constantine; Richardson Paul; Anderson Kenneth C
Proteasome inhibitor therapy in multiple myeloma.
Molecular cancer therapeutics 2005;4(4):686-92.
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2005: Hideshima Teru; Chauhan Dharminder; Ishitsuka Kenji; Yasui Hiroshi; Raje Noopur; Kumar Shaji; Podar Klaus; Mitsiades Constantine; Hideshima Hiromasa; Bonham Lynn; Munshi Nikhil C; Richardson Paul G; Singer Jack W; Anderson Kenneth C
Molecular characterization of PS-341 (bortezomib) resistance: implications for overcoming resistance using lysophosphatidic acid acyltransferase (LPAAT)-beta inhibitors.
Oncogene 2005;24(19):3121-9.
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2005: Kim Jeong H; Chu Stephanie C; Gramlich Jessica L; Pride Yuri B; Babendreier Emily; Chauhan Dharminder; Salgia Ravi; Podar Klaus; Griffin James D; Sattler Martin
Activation of the PI3K/mTOR pathway by BCR-ABL contributes to increased production of reactive oxygen species.
Blood 2005;105(4):1717-23.
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2005: Hayashi Toshiaki; Hideshima Teru; Akiyama Masaharu; Podar Klaus; Yasui Hiroshi; Raje Noopur; Kumar Shaji; Chauhan Dharminder; Treon Steven P; Richardson Paul; Anderson Kenneth C
Molecular mechanisms whereby immunomodulatory drugs activate natural killer cells: clinical application.
British journal of haematology 2005;128(2):192-203.
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2005: Lin Boris; Catley Laurence; LeBlanc Richard; Mitsiades Constantine; Burger Renate; Tai Yu-Tzu; Podar Klaus; Wartmann Markus; Chauhan Dharminder; Griffin James D; Anderson Kenneth C
Patupilone (epothilone B) inhibits growth and survival of multiple myeloma cells in vitro and in vivo.
Blood 2005;105(1):350-7.
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2005: Hideshima Teru; Podar Klaus; Chauhan Dharminder; Anderson Kenneth C
Cytokines and signal transduction.
Best practice & research. Clinical haematology 2005;18(4):509-24.
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2005: Chauhan Dharminder; Hideshima Teru; Anderson Kenneth C
Proteasome inhibition in multiple myeloma: therapeutic implication.
Annual review of pharmacology and toxicology 2005;45():465-76.
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2004: Catley Laurence; Tai Yu-Tzu; Shringarpure Reshma; Burger Renate; Son Moni Thi; Podar Klaus; Tassone Pierfrancesco; Chauhan Dharminder; Hideshima Teru; Denis Louis; Richardson Paul; Munshi Nikhil C; Anderson Kenneth C
Proteasomal degradation of topoisomerase I is preceded by c-Jun NH2-terminal kinase activation, Fas up-regulation, and poly(ADP-ribose) polymerase cleavage in SN38-mediated cytotoxicity against multiple myeloma.
Cancer research 2004;64(23):8746-53.
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2004: Raje Noopur; Kumar Shaji; Hideshima Teru; Ishitsuka Kenji; Chauhan Dharminder; Mitsiades Constantine; Podar Klaus; Le Gouill Steven; Richardson Paul; Munshi Nikhil C; Stirling David I; Antin Joseph H; Anderson Kenneth C
Combination of the mTOR inhibitor rapamycin and CC-5013 has synergistic activity in multiple myeloma.
Blood 2004;104(13):4188-93.
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2004: Hayashi Toshiaki; Hideshima Teru; Nguyen Aaron N; Munoz Olivier; Podar Klaus; Hamasaki Makoto; Ishitsuka Kenji; Yasui Hiroshi; Richardson Paul; Chakravarty Sarvajit; Murphy Alison; Chauhan Dharminder; Higgins Linda S; Anderson Kenneth C
Transforming growth factor beta receptor I kinase inhibitor down-regulates cytokine secretion and multiple myeloma cell growth in the bone marrow microenvironment.
Clinical cancer research : an official journal of the American Association for Cancer Research 2004;10(22):7540-6.
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2004: Hideshima Teru; Podar Klaus; Chauhan Dharminder; Ishitsuka Kenji; Mitsiades Constantine; Tai Yu-Tzu; Hamasaki Makoto; Raje Noopur; Hideshima Hiromasa; Schreiner George; Nguyen Aaron N; Navas Tony; Munshi Nikhil C; Richardson Paul G; Higgins Linda S; Anderson Kenneth C
p38 MAPK inhibition enhances PS-341 (bortezomib)-induced cytotoxicity against multiple myeloma cells.
Oncogene 2004;23(54):8766-76.
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2004: Le Gouill Steven; Podar Klaus; Amiot Martine; Hideshima Teru; Chauhan Dharminder; Ishitsuka Kenji; Kumar Shaji; Raje Noopur; Richardson Paul G; Harousseau Jean-Luc; Anderson Kenneth C
VEGF induces Mcl-1 up-regulation and protects multiple myeloma cells against apoptosis.
Blood 2004;104(9):2886-92.
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2004: Podar Klaus; Shringarpure Reshma; Tai Yu-Tzu; Simoncini Melissa; Sattler Martin; Ishitsuka Kenji; Richardson Paul G; Hideshima Teru; Chauhan Dharminder; Anderson Kenneth C
Caveolin-1 is required for vascular endothelial growth factor-triggered multiple myeloma cell migration and is targeted by bortezomib.
Cancer research 2004;64(20):7500-6.
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2004: Chauhan Dharminder; Li Guilan; Podar Klaus; Hideshima Teru; Mitsiades Constantine; Schlossman Robert; Munshi Nikhil; Richardson Paul; Cotter Finbarr E; Anderson Kenneth C
Targeting mitochondria to overcome conventional and bortezomib/proteasome inhibitor PS-341 resistance in multiple myeloma (MM) cells.
Blood 2004;104(8):2458-66.
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2004: Raje Noopur; Hideshima Teru; Davies Faith E; Chauhan Dharminder; Treon Steven P; Young Gloria; Tai Yu-Tzu; Avigan David; Gong Jianlin; Schlossman Robert L; Richardson Paul; Kufe Donald W; Anderson Kenneth C
Tumour cell/dendritic cell fusions as a vaccination strategy for multiple myeloma.
British journal of haematology 2004;125(3):343-52.
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2004: Podar Klaus; Mostoslavsky Gustavo; Sattler Martin; Tai Yu-Tzu; Hayashi Toshiaki; Catley Laurence P; Hideshima Teru; Mulligan Richard C; Chauhan Dharminder; Anderson Kenneth C
Critical role for hematopoietic cell kinase (Hck)-mediated phosphorylation of Gab1 and Gab2 docking proteins in interleukin 6-induced proliferation and survival of multiple myeloma cells.
The Journal of biological chemistry 2004;279(20):21658-65.
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2004: Podar Klaus; Catley Laurence P; Tai Yu-Tzu; Shringarpure Reshma; Carvalho Pedro; Hayashi Toshiaki; Burger Renate; Schlossman Robert L; Richardson Paul G; Pandite Lini N; Kumar Rakesh; Hideshima Teru; Chauhan Dharminder; Anderson Kenneth C
GW654652, the pan-inhibitor of VEGF receptors, blocks the growth and migration of multiple myeloma cells in the bone marrow microenvironment.
Blood 2004;103(9):3474-9.
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2004: Chauhan Dharminder; Li Guilan; Hideshima Teru; Podar Klaus; Shringarpure Reshma; Mitsiades Constantine; Munshi Nikhil; Yew P Renee; Anderson Kenneth C
Blockade of ubiquitin-conjugating enzyme CDC34 enhances anti-myeloma activity of Bortezomib/Proteasome inhibitor PS-341.
Oncogene 2004;23(20):3597-602.
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2004: Tai Yu-Tzu; Catley Laurence P; Mitsiades Constantine S; Burger Renate; Podar Klaus; Shringpaure Reshma; Hideshima Teru; Chauhan Dharminder; Hamasaki Makoto; Ishitsuka Kenji; Richardson Paul; Treon Steven P; Munshi Nikhil C; Anderson Kenneth C
Mechanisms by which SGN-40, a humanized anti-CD40 antibody, induces cytotoxicity in human multiple myeloma cells: clinical implications.
Cancer research 2004;64(8):2846-52.
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2004: Chauhan Dharminder; Li Guilan; Podar Klaus; Hideshima Teru; Shringarpure Reshma; Catley Laurence; Mitsiades Constantine; Munshi Nikhil; Tai Yu Tzu; Suh Nanjoo; Gribble Gordon W; Honda Tadashi; Schlossman Robert; Richardson Paul; Sporn Michael B; Anderson Kenneth C
The bortezomib/proteasome inhibitor PS-341 and triterpenoid CDDO-Im induce synergistic anti-multiple myeloma (MM) activity and overcome bortezomib resistance.
Blood 2004;103(8):3158-66.
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2004: Mitsiades Constantine S; Mitsiades Nicholas S; McMullan Ciaran J; Poulaki Vassiliki; Shringarpure Reshma; Akiyama Masaharu; Hideshima Teru; Chauhan Dharminder; Joseph Marie; Libermann Towia A; García-Echeverría Carlos; Pearson Mark A; Hofmann Francesco; Anderson Kenneth C; Kung Andrew L
Inhibition of the insulin-like growth factor receptor-1 tyrosine kinase activity as a therapeutic strategy for multiple myeloma, other hematologic malignancies, and solid tumors.
Cancer cell 2004;5(3):221-30.
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2004: Chauhan D; Li G; Auclair D; Hideshima T; Podar K; Mitsiades N; Mitsiades C; Chen L B; Munshi N; Saxena S; Anderson K C
2-Methoxyestardiol and bortezomib/proteasome-inhibitor overcome dexamethasone-resistance in multiple myeloma cells by modulating Heat Shock Protein-27.
Apoptosis : an international journal on programmed cell death 2004;9(2):149-55.
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2004: LeBlanc Richard; Hideshima Teru; Catley Laurence P; Shringarpure Reshma; Burger Renate; Mitsiades Nicholas; Mitsiades Constantine; Cheema Puneet; Chauhan Dharminder; Richardson Paul G; Anderson Kenneth C; Munshi Nikhil C
Immunomodulatory drug costimulates T cells via the B7-CD28 pathway.
Blood 2004;103(5):1787-90.
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2004: Munshi Nikhil C; Hideshima Teru; Carrasco Daniel; Shammas Masood; Auclair Daniel; Davies Faith; Mitsiades Nicholas; Mitsiades Constantine; Kim Ryung Suk; Li Cheng; Rajkumar S Vincent; Fonseca Rafael; Bergsagel Lief; Chauhan Dharminder; Anderson Kenneth C
Identification of genes modulated in multiple myeloma using genetically identical twin samples.
Blood 2004;103(5):1799-806.
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2004: Mitsiades Constantine S; Mitsiades Nicholas S; McMullan Ciaran J; Poulaki Vassiliki; Shringarpure Reshma; Hideshima Teru; Akiyama Masaharu; Chauhan Dharminder; Munshi Nikhil; Gu Xuesong; Bailey Charles; Joseph Marie; Libermann Towia A; Richon Victoria M; Marks Paul A; Anderson Kenneth C
Transcriptional signature of histone deacetylase inhibition in multiple myeloma: biological and clinical implications.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(2):540-5.
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2003: Hideshima Teru; Chauhan Dharminder; Hayashi Toshiaki; Podar Klaus; Akiyama Masaharu; Mitsiades Constantine; MItsiades Nicholas; Gong Baoqing; Bonham Lynn; de Vries Peter; Munshi Nikhil; Richardson Paul G; Singer Jack W; Anderson Kenneth C
Antitumor activity of lysophosphatidic acid acyltransferase-beta inhibitors, a novel class of agents, in multiple myeloma.
Cancer research 2003;63(23):8428-36.
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2003: Davies Faith E; Dring Ann M; Li Cheng; Rawstron Andrew C; Shammas Masood A; O'Connor Sheila M; Fenton James A L; Hideshima Teru; Chauhan Dharminder; Tai Isabella T; Robinson Elizabeth; Auclair Daniel; Rees Karen; Gonzalez David; Ashcroft A John; Dasgupta Ranjit; Mitsiades Constantine; Mitsiades Nicholas; Chen Lan B; Wong Wing H; Munshi Nikhil C; Morgan Gareth J; Anderson Kenneth C
Insights into the multistep transformation of MGUS to myeloma using microarray expression analysis.
Blood 2003;102(13):4504-11.
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2003: Hideshima Teru; Hayashi Toshiaki; Chauhan Dharminder; Akiyama Masaharu; Richardson Paul; Anderson Kenneth
Biologic sequelae of c-Jun NH(2)-terminal kinase (JNK) activation in multiple myeloma cell lines.
Oncogene 2003;22(54):8797-801.
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2003: Hideshima Teru; Chauhan Dharminder; Hayashi Toshiaki; Akiyama Masaharu; Mitsiades Nicholas; Mitsiades Constantine; Podar Klaus; Munshi Nikhil C; Richardson Paul G; Anderson Kenneth C
Proteasome inhibitor PS-341 abrogates IL-6 triggered signaling cascades via caspase-dependent downregulation of gp130 in multiple myeloma.
Oncogene 2003;22(52):8386-93.
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2003: Chauhan Dharminder; Li Guilan; Hideshima Teru; Podar Klaus; Mitsiades Constantine; Mitsiades Nicholas; Catley Laurence; Tai Yu Tzu; Hayashi Toshiaki; Shringarpure Reshma; Burger Renate; Munshi Nikhil; Ohtake Yasuyuki; Saxena Satya; Anderson Kenneth C
Hsp27 inhibits release of mitochondrial protein Smac in multiple myeloma cells and confers dexamethasone resistance.
Blood 2003;102(9):3379-86.
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2003: Mitsiades Constantine S; Mitsiades Nicholas S; Bronson Ron T; Chauhan Dharminder; Munshi Nikhil; Treon Steven P; Maxwell Christopher A; Pilarski Linda; Hideshima Teru; Hoffman Robert M; Anderson Kenneth C
Fluorescence imaging of multiple myeloma cells in a clinically relevant SCID/NOD in vivo model: biologic and clinical implications.
Cancer research 2003;63(20):6689-96.
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2003: Chauhan Dharminder; Li Guilan; Shringarpure Reshma; Podar Klaus; Ohtake Yasuyuki; Hideshima Teru; Anderson Kenneth C
Blockade of Hsp27 overcomes Bortezomib/proteasome inhibitor PS-341 resistance in lymphoma cells.
Cancer research 2003;63(19):6174-7.
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2003: Catley Laurence; Weisberg Ellen; Tai Yu-Tzu; Atadja Peter; Remiszewski Stacy; Hideshima Teru; Mitsiades Nicholas; Shringarpure Reshma; LeBlanc Richard; Chauhan Dharminder; Munshi Nikhil C; Schlossman Robert; Richardson Paul; Griffin James; Anderson Kenneth C
NVP-LAQ824 is a potent novel histone deacetylase inhibitor with significant activity against multiple myeloma.
Blood 2003;102(7):2615-22.
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2003: Shammas Masood A; Shmookler Reis Robert J; Akiyama Masaharu; Koley Hemanta; Chauhan Dharminder; Hideshima Teru; Goyal Raj K; Hurley Laurence H; Anderson Kenneth C; Munshi Nikhil C
Telomerase inhibition and cell growth arrest by G-quadruplex interactive agent in multiple myeloma.
Molecular cancer therapeutics 2003;2(9):825-33.
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2003: Tai Yu-Tzu; Podar Klaus; Catley Laurence; Tseng Yu-Hua; Akiyama Masaharu; Shringarpure Reshma; Burger Renate; Hideshima Teru; Chauhan Dharminder; Mitsiades Nicholas; Richardson Paul; Munshi Nikhil C; Kahn C Ronald; Mitsiades Constantine; Anderson Kenneth C
Insulin-like growth factor-1 induces adhesion and migration in human multiple myeloma cells via activation of beta1-integrin and phosphatidylinositol 3'-kinase/AKT signaling.
Cancer research 2003;63(18):5850-8.
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2003: Chauhan Dharminder; Li Guilan; Sattler Martin; Podar Klaus; Mitsiades Constantine; Mitsiades Nicholas; Munshi Nikhil; Hideshima Teru; Anderson Kenneth C
Superoxide-dependent and -independent mitochondrial signaling during apoptosis in multiple myeloma cells.
Oncogene 2003;22(40):6296-300.
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2003: Chauhan Dharminder; Hideshima Teru; Anderson Kenneth C
Apoptotic signaling in multiple myeloma: therapeutic implications.
International journal of hematology 2003;78(2):114-20.
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2003: Chauhan D; Anderson K C
Mechanisms of cell death and survival in multiple myeloma (MM): Therapeutic implications.
Apoptosis : an international journal on programmed cell death 2003;8(4):337-43.
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2003: Hayashi Toshiaki; Hideshima Teru; Akiyama Masaharu; Raje Noopur; Richardson Paul; Chauhan Dharminder; Anderson Kenneth C
Ex vivo induction of multiple myeloma-specific cytotoxic T lymphocytes.
Blood 2003;102(4):1435-42.
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2003: Hayashi Toshiaki; Treon Steven P; Hideshima Teru; Tai Yu-Tzu; Akiyama Masaharu; Richardson Paul; Chauhan Dharminder; Grewal Iqbal S; Anderson Kenneth C
Recombinant humanized anti-CD40 monoclonal antibody triggers autologous antibody-dependent cell-mediated cytotoxicity against multiple myeloma cells.
British journal of haematology 2003;121(4):592-6.
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2003: Chauhan Dharminder; Li Guilan; Hideshima Teru; Podar Klaus; Mitsiades Constantine; Mitsiades Nicholas; Munshi Nikhil; Kharbanda Surender; Anderson Kenneth C
JNK-dependent release of mitochondrial protein, Smac, during apoptosis in multiple myeloma (MM) cells.
The Journal of biological chemistry 2003;278(20):17593-6.
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2003: Mitsiades Nicholas; Mitsiades Constantine S; Richardson Paul G; McMullan Ciaran; Poulaki Vassiliki; Fanourakis Galinos; Schlossman Robert; Chauhan Dharminder; Munshi Nikhil C; Hideshima Teru; Richon Victoria M; Marks Paul A; Anderson Kenneth C
Molecular sequelae of histone deacetylase inhibition in human malignant B cells.
Blood 2003;101(10):4055-62.
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2003: Chauhan Dharminder; Li Guilan; Auclair Daniel; Hideshima Teru; Richardson Paul; Podar Klaus; Mitsiades Nicholas; Mitsiades Constantine; Li Cheng; Kim Ryung Suk; Munshi Nikhil; Chen Lan Bo; Wong Wing; Anderson Kenneth C
Identification of genes regulated by 2-methoxyestradiol (2ME2) in multiple myeloma cells using oligonucleotide arrays.
Blood 2003;101(9):3606-14.
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2003: Greenstein Stephanie; Krett Nancy L; Kurosawa Yoshihiro; Ma Chunguang; Chauhan Dharminder; Hideshima Teru; Anderson Kenneth C; Rosen Steven T
Characterization of the MM.1 human multiple myeloma (MM) cell lines: a model system to elucidate the characteristics, behavior, and signaling of steroid-sensitive and -resistant MM cells.
Experimental hematology 2003;31(4):271-82.
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2003: Mitsiades Nicholas; Mitsiades Constantine S; Richardson Paul G; Poulaki Vassiliki; Tai Yu-Tzu; Chauhan Dharminder; Fanourakis Galinos; Gu Xuesong; Bailey Charles; Joseph Marie; Libermann Towia A; Schlossman Robert; Munshi Nikhil C; Hideshima Teru; Anderson Kenneth C
The proteasome inhibitor PS-341 potentiates sensitivity of multiple myeloma cells to conventional chemotherapeutic agents: therapeutic applications.
Blood 2003;101(6):2377-80.
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2003: Podar Klaus; Tai Yu-Tzu; Cole Craig E; Hideshima Teru; Sattler Martin; Hamblin Angela; Mitsiades Nicholas; Schlossman Robert L; Davies Faith E; Morgan Gareth J; Munshi Nikhil C; Chauhan Dharminder; Anderson Kenneth C
Essential role of caveolae in interleukin-6- and insulin-like growth factor I-triggered Akt-1-mediated survival of multiple myeloma cells.
The Journal of biological chemistry 2003;278(8):5794-801.
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2003: Hideshima Teru; Mitsiades Constantine; Akiyama Masaharu; Hayashi Toshiaki; Chauhan Dharminder; Richardson Paul; Schlossman Robert; Podar Klaus; Munshi Nikhil C; Mitsiades Nicholas; Anderson Kenneth C
Molecular mechanisms mediating antimyeloma activity of proteasome inhibitor PS-341.
Blood 2003;101(4):1530-4.
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2003: Akiyama Masaharu; Hideshima Teru; Hayashi Toshiaki; Tai Yu-Tzu; Mitsiades Constantine S; Mitsiades Nicholas; Chauhan Dharminder; Richardson Paul; Munshi Nikhil C; Anderson Kenneth C
Nuclear factor-kappaB p65 mediates tumor necrosis factor alpha-induced nuclear translocation of telomerase reverse transcriptase protein.
Cancer research 2003;63(1):18-21.
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2003: Hideshima Teru; Akiyama Masaharu; Hayashi Toshiaki; Richardson Paul; Schlossman Robert; Chauhan Dharminder; Anderson Kenneth C
Targeting p38 MAPK inhibits multiple myeloma cell growth in the bone marrow milieu.
Blood 2003;101(2):703-5.
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2002: Yamaguchi Toru; Yamauchi Mika; Sugimoto Toshitsugu; Chauhan Dharminder; Anderson Kenneth C; Brown Edward M; Chihara Kazuo
The extracellular calcium Ca2+o-sensing receptor is expressed in myeloma cells and modulates cell proliferation.
Biochemical and biophysical research communications 2002;299(4):532-8.
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2002: Richardson Paul G; Schlossman Robert L; Weller Edie; Hideshima Teru; Mitsiades Constantine; Davies Faith; LeBlanc Richard; Catley Laurence P; Doss Deborah; Kelly Kathleen; McKenney Mary; Mechlowicz Julie; Freeman Andrea; Deocampo Reggie; Rich Rebecca; Ryoo Joan J; Chauhan Dharminder; Balinski Kathe; Zeldis Jerome; Anderson Kenneth C
Immunomodulatory drug CC-5013 overcomes drug resistance and is well tolerated in patients with relapsed multiple myeloma.
Blood 2002;100(9):3063-7.
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2002: Mitsiades Nicholas; Mitsiades Constantine S; Poulaki Vassiliki; Chauhan Dharminder; Fanourakis Galinos; Gu Xuesong; Bailey Charles; Joseph Marie; Libermann Towia A; Treon Steven P; Munshi Nikhil C; Richardson Paul G; Hideshima Teru; Anderson Kenneth C
Molecular sequelae of proteasome inhibition in human multiple myeloma cells.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(22):14374-9.
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2002: Chauhan Dharminder; Catley Laurence; Hideshima Teru; Li Guilan; Leblanc Richard; Gupta Deepak; Sattler Martin; Richardson Paul; Schlossman Robert L; Podar Klaus; Weller Edie; Munshi Nikhil; Anderson Kenneth C
2-Methoxyestradiol overcomes drug resistance in multiple myeloma cells.
Blood 2002;100(6):2187-94.
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2002: Hayashi Toshiaki; Hideshima Teru; Akiyama Masaharu; Richardson Paul; Schlossman Robert L; Chauhan Dharminder; Munshi Nikhil C; Waxman Samuel; Anderson Kenneth C
Arsenic trioxide inhibits growth of human multiple myeloma cells in the bone marrow microenvironment.
Molecular cancer therapeutics 2002;1(10):851-60.
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2002: Munshi Nikhil C; Hideshima Teru; Chauhan Dharminder; Richardson Paul; Anderson Kenneth C
Novel biologically based therapies for multiple myeloma.
International journal of hematology 2002;76 Suppl 1():340-1.
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2002: Mitsiades Constantine S; Mitsiades Nicholas; Poulaki Vassiliki; Schlossman Robert; Akiyama Masaharu; Chauhan Dharminder; Hideshima Teru; Treon Steven P; Munshi Nikhil C; Richardson Paul G; Anderson Kenneth C
Activation of NF-kappaB and upregulation of intracellular anti-apoptotic proteins via the IGF-1/Akt signaling in human multiple myeloma cells: therapeutic implications.
Oncogene 2002;21(37):5673-83.
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2002: Gupta Deepak; Podar Klaus; Tai Yu Tzu; Lin Boris; Hideshima Teru; Akiyama Masaharu; LeBlanc Richard; Catley Laurence; Mitsiades Nicholas; Mitsiades Constantine; Chauhan Dharminder; Munshi Nikhil C; Anderson Kenneth C
beta-lapachone, a novel plant product, overcomes drug resistance in human multiple myeloma cells.
Experimental hematology 2002;30(7):711-20.
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2002: Akiyama Masaharu; Hideshima Teru; Hayashi Toshiaki; Tai Yu-Tzu; Mitsiades Constantine S; Mitsiades Nicholas; Chauhan Dharminder; Richardson Paul; Munshi Nikhil C; Anderson Kenneth C
Cytokines modulate telomerase activity in a human multiple myeloma cell line.
Cancer research 2002;62(13):3876-82.
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2002: Mitsiades Nicholas; Mitsiades Constantine S; Poulaki Vassiliki; Chauhan Dharminder; Richardson Paul G; Hideshima Teru; Munshi Nikhil C; Treon Steven P; Anderson Kenneth C
Apoptotic signaling induced by immunomodulatory thalidomide analogs in human multiple myeloma cells: therapeutic implications.
Blood 2002;99(12):4525-30.
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2002: Mitsiades Nicholas; Mitsiades Constantine S; Poulaki Vassiliki; Chauhan Dharminder; Richardson Paul G; Hideshima Teru; Munshi Nikhil; Treon Steven P; Anderson Kenneth C
Biologic sequelae of nuclear factor-kappaB blockade in multiple myeloma: therapeutic applications.
Blood 2002;99(11):4079-86.
-
2002: Hideshima Teru; Chauhan Dharminder; Hayashi Toshiaki; Podar Klaus; Akiyama Masaharu; Gupta Deepak; Richardson Paul; Munshi Nikhil; Anderson Kenneth C
The biological sequelae of stromal cell-derived factor-1alpha in multiple myeloma.
Molecular cancer therapeutics 2002;1(7):539-44.
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2002: Hideshima Teru; Chauhan Dharminder; Richardson Paul; Mitsiades Constantine; Mitsiades Nicholas; Hayashi Toshiaki; Munshi Nikhil; Dang Lenny; Castro Alfredo; Palombella Vito; Adams Julian; Anderson Kenneth C
NF-kappa B as a therapeutic target in multiple myeloma.
The Journal of biological chemistry 2002;277(19):16639-47.
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2002: Semenov Igor; Akyuz Canan; Roginskaya Vera; Chauhan Dharminder; Corey Seth J
Growth inhibition and apoptosis of myeloma cells by the CDK inhibitor flavopiridol.
Leukemia research 2002;26(3):271-80.
-
2002: Podar Klaus; Tai Yu-Tzu; Lin Boris K; Narsimhan Radha P; Sattler Martin; Kijima Takashi; Salgia Ravi; Gupta Deepak; Chauhan Dharminder; Anderson Kenneth C
Vascular endothelial growth factor-induced migration of multiple myeloma cells is associated with beta 1 integrin- and phosphatidylinositol 3-kinase-dependent PKC alpha activation.
The Journal of biological chemistry 2002;277(10):7875-81.
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2002: Chauhan Dharminder; Auclair Daniel; Robinson Elisabeth K; Hideshima Teru; Li Guilan; Podar Klaus; Gupta Deepak; Richardson Paul; Schlossman Robert L; Krett Nancy; Chen Lan Bo; Munshi Nikhil C; Anderson Kenneth C
Identification of genes regulated by dexamethasone in multiple myeloma cells using oligonucleotide arrays.
Oncogene 2002;21(9):1346-58.
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2001: Gupta D; Treon S P; Shima Y; Hideshima T; Podar K; Tai Y T; Lin B; Lentzsch S; Davies F E; Chauhan D; Schlossman R L; Richardson P; Ralph P; Wu L; Payvandi F; Muller G; Stirling D I; Anderson K C
Adherence of multiple myeloma cells to bone marrow stromal cells upregulates vascular endothelial growth factor secretion: therapeutic applications.
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 2001;15(12):1950-61.
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2001: Hideshima T; Chauhan D; Podar K; Schlossman R L; Richardson P; Anderson K C
Novel therapies targeting the myeloma cell and its bone marrow microenvironment.
Seminars in oncology 2001;28(6):607-12.
-
2001: Hideshima T; Nakamura N; Chauhan D; Anderson K C
Biologic sequelae of interleukin-6 induced PI3-K/Akt signaling in multiple myeloma.
Oncogene 2001;20(42):5991-6000.
-
2001: Hideshima T; Chauhan D; Schlossman R; Richardson P; Anderson K C
The role of tumor necrosis factor alpha in the pathophysiology of human multiple myeloma: therapeutic applications.
Oncogene 2001;20(33):4519-27.
-
2001: Podar K; Tai Y T; Davies F E; Lentzsch S; Sattler M; Hideshima T; Lin B K; Gupta D; Shima Y; Chauhan D; Mitsiades C; Raje N; Richardson P; Anderson K C
Vascular endothelial growth factor triggers signaling cascades mediating multiple myeloma cell growth and migration.
Blood 2001;98(2):428-35.
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2001: Davies F E; Raje N; Hideshima T; Lentzsch S; Young G; Tai Y T; Lin B; Podar K; Gupta D; Chauhan D; Treon S P; Richardson P G; Schlossman R L; Morgan G J; Muller G W; Stirling D I; Anderson K C
Thalidomide and immunomodulatory derivatives augment natural killer cell cytotoxicity in multiple myeloma.
Blood 2001;98(1):210-6.
-
2001: Chauhan D; Hideshima T; Rosen S; Reed J C; Kharbanda S; Anderson K C
Apaf-1/cytochrome c-independent and Smac-dependent induction of apoptosis in multiple myeloma (MM) cells.
The Journal of biological chemistry 2001;276(27):24453-6.
-
2001: Hideshima T; Richardson P; Chauhan D; Palombella V J; Elliott P J; Adams J; Anderson K C
The proteasome inhibitor PS-341 inhibits growth, induces apoptosis, and overcomes drug resistance in human multiple myeloma cells.
Cancer research 2001;61(7):3071-6.
-
2001: Chauhan D; Anderson K C
Apoptosis in multiple myeloma: therapeutic implications.
Apoptosis : an international journal on programmed cell death 2001;6(1-2):47-55.
-
2000: Tai Y T; Teoh G; Lin B; Davies F E; Chauhan D; Treon S P; Raje N; Hideshima T; Shima Y; Podar K; Anderson K C
Ku86 variant expression and function in multiple myeloma cells is associated with increased sensitivity to DNA damage.
Journal of immunology (Baltimore, Md. : 1950) 2000;165(11):6347-55.
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2000: Treon S P; Maimonis P; Bua D; Young G; Raje N; Mollick J; Chauhan D; Tai Y T; Hideshima T; Shima Y; Hilgers J; von Mensdorff-Pouilly S; Belch A R; Pilarski L M; Anderson K C
Elevated soluble MUC1 levels and decreased anti-MUC1 antibody levels in patients with multiple myeloma.
Blood 2000;96(9):3147-53.
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2000: Hideshima T; Chauhan D; Shima Y; Raje N; Davies F E; Tai Y T; Treon S P; Lin B; Schlossman R L; Richardson P; Muller G; Stirling D I; Anderson K C
Thalidomide and its analogs overcome drug resistance of human multiple myeloma cells to conventional therapy.
Blood 2000;96(9):2943-50.
-
2000: Chauhan D; Pandey P; Hideshima T; Treon S; Raje N; Davies F E; Shima Y; Tai Y T; Rosen S; Avraham S; Kharbanda S; Anderson K C
SHP2 mediates the protective effect of interleukin-6 against dexamethasone-induced apoptosis in multiple myeloma cells.
The Journal of biological chemistry 2000;275(36):27845-50.
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2000: Raje N; Kica G; Chauhan D; Zhang Y; Teoh G; Treon S P; Hideshima T; Deng J H; Gao S J; Alsina M; Wally J; Davies F E; Tai Y T; Pinkus G S; Pinkus J L; Skinner M; Comenzo R L; Anderson K C
Kaposi's sarcoma-associated herpesvirus gene sequences are detectable at low copy number in primary amyloidosis.
Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis 2000;7(2):126-32.
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2000: Hideshima T; Chauhan D; Teoh G; Raje N; Treon S P; Tai Y T; Shima Y; Anderson K C
Characterization of signaling cascades triggered by human interleukin-6 versus Kaposi's sarcoma-associated herpes virus-encoded viral interleukin 6.
Clinical cancer research : an official journal of the American Association for Cancer Research 2000;6(3):1180-9.
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2000: Tai Y T; Teoh G; Shima Y; Chauhan D; Treon S P; Raje N; Hideshima T; Davies F E; Anderson K C
Isolation and characterization of human multiple myeloma cell enriched populations.
Journal of immunological methods 2000;235(1-2):11-9.
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2000: Teoh G; Tai Y T; Urashima M; Shirahama S; Matsuzaki M; Chauhan D; Treon S P; Raje N; Hideshima T; Shima Y; Anderson K C
CD40 activation mediates p53-dependent cell cycle regulation in human multiple myeloma cell lines.
Blood 2000;95(3):1039-46.
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1999: Chauhan D; Hideshima T; Pandey P; Treon S; Teoh G; Raje N; Rosen S; Krett N; Husson H; Avraham S; Kharbanda S; Anderson K C
RAFTK/PYK2-dependent and -independent apoptosis in multiple myeloma cells.
Oncogene 1999;18(48):6733-40.
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1999: Chauhan D; Hideshima T; Treon S; Teoh G; Raje N; Yoshihimito S; Tai Y T; Li W; Fan J; DeCaprio J; Anderson K C
Functional interaction between retinoblastoma protein and stress-activated protein kinase in multiple myeloma cells.
Cancer research 1999;59(6):1192-5.
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1999: Raje N; Gong J; Chauhan D; Teoh G; Avigan D; Wu Z; Chen D; Treon S P; Webb I J; Kufe D W; Anderson K C
Bone marrow and peripheral blood dendritic cells from patients with multiple myeloma are phenotypically and functionally normal despite the detection of Kaposi's sarcoma herpesvirus gene sequences.
Blood 1999;93(5):1487-95.
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1999: Chauhan D; Bharti A; Raje N; Gustafson E; Pinkus G S; Pinkus J L; Teoh G; Hideshima T; Treon S P; Fingeroth J D; Anderson K C
Detection of Kaposi's sarcoma herpesvirus DNA sequences in multiple myeloma bone marrow stromal cells.
Blood 1999;93(5):1482-6.
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1999: Treon S P; Mollick J A; Urashima M; Teoh G; Chauhan D; Ogata A; Raje N; Hilgers J H; Nadler L; Belch A R; Pilarski L M; Anderson K C
Muc-1 core protein is expressed on multiple myeloma cells and is induced by dexamethasone.
Blood 1999;93(4):1287-98.
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1998: Teoh G; Chen L; Urashima M; Tai Y T; Celi L A; Chen D; Chauhan D; Ogata A; Finberg R W; Webb I J; Kufe D W; Anderson K C
Adenovirus vector-based purging of multiple myeloma cells.
Blood 1998;92(12):4591-601.
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1998: Treon S P; Teoh G; Urashima M; Ogata A; Chauhan D; Webb I J; Anderson K C
Anti-estrogens induce apoptosis of multiple myeloma cells.
Blood 1998;92(5):1749-57.
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1998: Teoh G; Urashima M; Greenfield E A; Nguyen K A; Lee J F; Chauhan D; Ogata A; Treon S P; Anderson K C
The 86-kD subunit of Ku autoantigen mediates homotypic and heterotypic adhesion of multiple myeloma cells.
The Journal of clinical investigation 1998;101(6):1379-88.
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1997: Urashima M; Teoh G; Ogata A; Chauhan D; Treon S P; Sugimoto Y; Kaihara C; Matsuzaki M; Hoshi Y; DeCaprio J A; Anderson K C
Characterization of p16(INK4A) expression in multiple myeloma and plasma cell leukemia.
Clinical cancer research : an official journal of the American Association for Cancer Research 1997;3(11):2173-9.
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1997: Urashima M; DeCaprio J A; Chauhan D; Teoh G; Ogata A; Treon S P; Hoshi Y; Anderson K C
p16INK4A promotes differentiation and inhibits apoptosis of JKB acute lymphoblastic leukemia cells.
Blood 1997;90(10):4106-15.
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1997: Teoh G; Urashima M; Ogata A; Chauhan D; DeCaprio J A; Treon S P; Schlossman R L; Anderson K C
MDM2 protein overexpression promotes proliferation and survival of multiple myeloma cells.
Blood 1997;90(5):1982-92.
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1997: Ogata A; Chauhan D; Urashima M; Teoh G; Treon S P; Anderson K C
Blockade of mitogen-activated protein kinase cascade signaling in interleukin 6-independent multiple myeloma cells.
Clinical cancer research : an official journal of the American Association for Cancer Research 1997;3(6):1017-22.
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1997: Chauhan D; Kharbanda S; Ogata A; Urashima M; Teoh G; Robertson M; Kufe D W; Anderson K C
Interleukin-6 inhibits Fas-induced apoptosis and stress-activated protein kinase activation in multiple myeloma cells.
Blood 1997;89(1):227-34.
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1996: Urashima M; Hoshi Y; Sugimoto Y; Kaihara C; Matsuzaki M; Chauhan D; Ogata A; Teoh G; DeCaprio J A; Anderson K C
A novel pre-B acute lymphoblastic leukemia cell line with chromosomal translocation between p16(INK4A)/p15(INK4B) tumor suppressor and immunoglobulin heavy chain genes: TGFbeta/IL-7 inhibitory signaling mechanism.
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 1996;10(10):1576-83.
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1996: Urashima M; Ogata A; Chauhan D; Vidriales M B; Teoh G; Hoshi Y; Schlossman R L; DeCaprio J A; Anderson K C
Interleukin-6 promotes multiple myeloma cell growth via phosphorylation of retinoblastoma protein.
Blood 1996;88(6):2219-27.
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1996: Dedera D A; Urashima M; Chauhan D; LeBrun D P; Bronson R T; Anderson K C
Interleukin-6 is required for pristane-induced plasma cell hyperplasia in mice.
British journal of haematology 1996;94(1):53-61.
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1996: Urashima M; Chauhan D; Hatziyanni M; Ogata A; Hollenbaugh D; Aruffo A; Anderson K C
CD40 ligand triggers interleukin-6 mediated B cell differentiation.
Leukemia research 1996;20(6):507-15.
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1996: Urashima M; Ogata A; Chauhan D; Hatziyanni M; Vidriales M B; Dedera D A; Schlossman R L; Anderson K C
Transforming growth factor-beta1: differential effects on multiple myeloma versus normal B cells.
Blood 1996;87(5):1928-38.
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1996: Chauhan D; Uchiyama H; Akbarali Y; Urashima M; Yamamoto K; Libermann T A; Anderson K C
Multiple myeloma cell adhesion-induced interleukin-6 expression in bone marrow stromal cells involves activation of NF-kappa B.
Blood 1996;87(3):1104-12.
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1995: Chauhan D; Kharbanda S M; Ogata A; Urashima M; Frank D; Malik N; Kufe D W; Anderson K C
Oncostatin M induces association of Grb2 with Janus kinase JAK2 in multiple myeloma cells.
The Journal of experimental medicine 1995;182(6):1801-6.
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1995: Chauhan D; Uchiyama H; Urashima M; Yamamoto K; Anderson K C
Regulation of interleukin 6 in multiple myeloma and bone marrow stromal cells.
Stem cells (Dayton, Ohio) 1995;13 Suppl 2():35-9.
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1995: Chauhan D; Kharbanda S M; Uchiyama H; Urashima M; Anderson K C
Activation of pp90rsk and early growth response-1 gene expression by pokeweed mitogen in human B cells.
Leukemia research 1995;19(5):337-44.
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1995: Urashima M; Chauhan D; Uchiyama H; Freeman G J; Anderson K C
CD40 ligand triggered interleukin-6 secretion in multiple myeloma.
Blood 1995;85(7):1903-12.
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1994: Chauhan D; Kharbanda S; Uchiyama H; Urashima M; Fragoso R; Sen J; Kufe D W; Anderson K C
Identification of upstream signals regulating interleukin-6 gene expression during in vitro treatment of human B cells with pokeweed mitogen.
Blood 1994;84(7):2243-52.
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1994: Kim I; Uchiyama H; Chauhan D; Anderson K C
Cell surface expression and functional significance of adhesion molecules on human myeloma-derived cell lines.
British journal of haematology 1994;87(3):483-93.
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1994: Chauhan D; Kharbanda S M; Uchiyama H; Sukhatme V P; Kufe D W; Anderson K C
Involvement of serum response element in okadaic acid-induced EGR-1 transcription in human T-cells.
Cancer research 1994;54(8):2234-9.
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1993: Uchiyama H; Barut B A; Mohrbacher A F; Chauhan D; Anderson K C
Adhesion of human myeloma-derived cell lines to bone marrow stromal cells stimulates interleukin-6 secretion.
Blood 1993;82(12):3712-20.
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1993: Barut B; Chauhan D; Uchiyama H; Anderson K C
Interleukin-6 functions as an intracellular growth factor in hairy cell leukemia in vitro.
The Journal of clinical investigation 1993;92(5):2346-52.
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1993: Chauhan D; Kharbanda S M; Rubin E; Barut B A; Mohrbacher A; Kufe D W; Anderson K C
Regulation of c-jun gene expression in human T lymphocytes.
Blood 1993;81(6):1540-8.
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1992: Anderson K C; Morimoto C; Paul S R; Chauhan D; Williams D; Cochran M; Barut B A
Interleukin-11 promotes accessory cell-dependent B-cell differentiation in humans.
Blood 1992;80(11):2797-804.
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1992: Uchiyama H; Barut B A; Chauhan D; Cannistra S A; Anderson K C
Characterization of adhesion molecules on human myeloma cell lines.
Blood 1992;80(9):2306-14.
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1992: Barut B A; Zon L I; Cochran M K; Paul S R; Chauhan D; Mohrbacher A; Fingeroth J; Anderson K C
Role of interleukin 6 in the growth of myeloma-derived cell lines.
Leukemia research 1992;16(10):951-9.
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