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Jun-ichi Abe

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Chemicals & Drugs

Physiology

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Protein Structure, Tertiary

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Patrizia Nigro; Kimio Satoh; Michael R O'Dell; Nwe Nwe Soe; Zhaoqiang Cui; Amy Mohan; Jun-ichi Abe; Jeffrey D Alexis; Janet D Sparks; Bradford C Berk
Cyclophilin A is an inflammatory mediator that promotes atherosclerosis in apolipoprotein E-deficient mice.
Clint L Miller; Masayoshi Oikawa; Yujun Cai; Andrew P Wojtovich; David J Nagel; Xiangbin Xu; Haodong Xu; Vince Florio; Sergei D Rybalkin; Joseph A Beavo; Yiu-Fai Chen; Jian-Dong Li; Burns C Blaxall; Jun-ichi Abe; Chen Yan
Role of Ca2+/calmodulin-stimulated cyclic nucleotide phosphodiesterase 1 in mediating cardiomyocyte hypertrophy.
Zhibo Lu; Jun-ichi Abe; Jack Taunton; Yan Lu; Tetsuro Shishido; Carolyn McClain; Chen Yan; Sheng Ping Xu; Thomas M Spangenberg; Haodong Xu
Reactive oxygen species-induced activation of p90 ribosomal S6 kinase prolongs cardiac repolarization through inhibiting outward K+ channel activity.

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All Publications

2011: Patrizia Nigro; Kimio Satoh; Michael R O'Dell; Nwe Nwe Soe; Zhaoqiang Cui; Amy Mohan; Jun-ichi Abe; Jeffrey D Alexis; Janet D Sparks; Bradford C Berk
Cyclophilin A is an inflammatory mediator that promotes atherosclerosis in apolipoprotein E-deficient mice.
The Journal of experimental medicine 2011;208(1):53-66.
2009: Clint L Miller; Masayoshi Oikawa; Yujun Cai; Andrew P Wojtovich; David J Nagel; Xiangbin Xu; Haodong Xu; Vince Florio; Sergei D Rybalkin; Joseph A Beavo; Yiu-Fai Chen; Jian-Dong Li; Burns C Blaxall; Jun-ichi Abe; Chen Yan
Role of Ca2+/calmodulin-stimulated cyclic nucleotide phosphodiesterase 1 in mediating cardiomyocyte hypertrophy.
Circulation research 2009;105(10):956-64.
2008: Zhibo Lu; Jun-ichi Abe; Jack Taunton; Yan Lu; Tetsuro Shishido; Carolyn McClain; Chen Yan; Sheng Ping Xu; Thomas M Spangenberg; Haodong Xu
Reactive oxygen species-induced activation of p90 ribosomal S6 kinase prolongs cardiac repolarization through inhibiting outward K+ channel activity.
Circulation research 2008;103(3):269-78.
2008: Kimio Satoh; Tetsuya Matoba; Jun Suzuki; Michael R O'Dell; Patrizia Nigro; Zhaoqiang Cui; Amy Mohan; Shi Pan; Lingli Li; Zheng-Gen Jin; Chen Yan; Jun-ichi Abe; Bradford C Berk
Cyclophilin A mediates vascular remodeling by promoting inflammation and vascular smooth muscle cell proliferation.
Circulation 2008;117(24):3088-98.
2008: Tetsuro Shishido; Chang-Hoon Woo; Bo Ding; Carolyn McClain; Carlos A Molina; Chen Yan; Jay Yang; Jun-ichi Abe
Effects of MEK5/ERK5 association on small ubiquitin-related modification of ERK5: implications for diabetic ventricular dysfunction after myocardial infarction.
Circulation research 2008;102(11):1416-25.
2008: Lingli Li; Revati J Tatake; Kanchana Natarajan; Yoji Taba; Gwenaele Garin; Caspar Tai; Ed Leung; James Surapisitchat; Masanori Yoshizumi; Chen Yan; Jun-ichi Abe; Bradford C Berk
Fluid shear stress inhibits TNF-mediated JNK activation via MEK5-BMK1 in endothelial cells.
Biochemical and biophysical research communications 2008;370(1):159-63.
2008: Chang-Hoon Woo; Tetsuro Shishido; Carolyn McClain; Jae Hyang Lim; Jian-Dong Li; Jay Yang; Chen Yan; Jun-ichi Abe
Extracellular signal-regulated kinase 5 SUMOylation antagonizes shear stress-induced antiinflammatory response and endothelial nitric oxide synthase expression in endothelial cells.
Circulation research 2008;102(5):538-45.
2007: Gwenaele Garin; Jun-ichi Abe; Amy Mohan; Weimin Lu; Chen Yan; Andrew C Newby; Arshad Rhaman; Bradford C Berk
Flow antagonizes TNF-alpha signaling in endothelial cells by inhibiting caspase-dependent PKC zeta processing.
Circulation research 2007;101(1):97-105.
2007: Chen Yan; Clint L Miller; Jun-ichi Abe
Regulation of phosphodiesterase 3 and inducible cAMP early repressor in the heart.
Circulation research 2007;100(4):489-501.
2007: Chen Yan; Bo Ding; Tetsuro Shishido; Chang-Hoon Woo; Seigo Itoh; Kye-Im Jeon; Weimin Liu; Haodong Xu; Carolyn McClain; Carlos A Molina; Burns C Blaxall; Jun-ichi Abe
Activation of extracellular signal-regulated kinase 5 reduces cardiac apoptosis and dysfunction via inhibition of a phosphodiesterase 3A/inducible cAMP early repressor feedback loop.
Circulation research 2007;100(4):510-9.
2006: Chang-Hoon Woo; Michael P Massett; Tetsuro Shishido; Seigo Itoh; Bo Ding; Carolyn McClain; Wenyi Che; Sreesatya Raju Vulapalli; Chen Yan; Jun-ichi Abe
ERK5 activation inhibits inflammatory responses via peroxisome proliferator-activated receptor delta (PPARdelta) stimulation.
The Journal of biological chemistry 2006;281(43):32164-74.
2006: Naoya Maekawa; Jun-ichi Abe; Tetsuro Shishido; Seigo Itoh; Bo Ding; Virendra K Sharma; Shey-Shing Sheu; Burns C Blaxall; Bradford C Berk
Inhibiting p90 ribosomal S6 kinase prevents (Na+)-H+ exchanger-mediated cardiac ischemia-reperfusion injury.
Circulation 2006;113(21):2516-23.
2006: Seigo Itoh; Bo Ding; Tetsuro Shishido; nicole lerner-marmarosh; Nadan Wang; Naoya Maekawa; Bradford C Berk; Yasuchika Takeishi; Chen Yan; Burns C Blaxall; Jun-ichi Abe
Role of p90 ribosomal S6 kinase-mediated prorenin-converting enzyme in ischemic and diabetic myocardium.
Circulation 2006;113(14):1787-98.
2005: Bo Ding; Jun-ichi Abe; Heng Wei; Haodong Xu; Wenyi Che; Toru Aizawa; Weimin Liu; Carlos A Molina; Junichi Sadoshima; Burns C Blaxall; Bradford C Berk; Chen Yan
A positive feedback loop of phosphodiesterase 3 (PDE3) and inducible cAMP early repressor (ICER) leads to cardiomyocyte apoptosis.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(41):14771-6.
2005: Seigo Itoh; Serge Lemay; Masaki Osawa; Wenyi Che; Yuntao Duan; Andrew J Tompkins; Paul S Brookes; Shey-Shing Sheu; Jun-ichi Abe
Mitochondrial Dok-4 recruits Src kinase and regulates NF-kappaB activation in endothelial cells.
The Journal of biological chemistry 2005;280(28):26383-96.
2005: Seigo Itoh; Bo Ding; Christopher P Bains; Nadan Wang; Yasuchika Takeishi; Thunder Jalili; George L King; Richard A Walsh; Chen Yan; Jun-ichi Abe
Role of p90 ribosomal S6 kinase (p90RSK) in reactive oxygen species and protein kinase C beta (PKC-beta)-mediated cardiac troponin I phosphorylation.
The Journal of biological chemistry 2005;280(25):24135-42.
2005: Xinchun Pi; Gwenaele Garin; Liang Xie; Qinlei Zheng; Heng Wei; Jun-ichi Abe; Chen Yan; Bradford C Berk
BMK1/ERK5 is a novel regulator of angiogenesis by destabilizing hypoxia inducible factor 1alpha.
Circulation research 2005;96(11):1145-51.
2005: Bo Ding; Jun-ichi Abe; Heng Wei; Qunhua Huang; Richard A Walsh; Carlos A Molina; Allan Zhao; Junichi Sadoshima; Burns C Blaxall; Bradford C Berk; Chen Yan
Functional role of phosphodiesterase 3 in cardiomyocyte apoptosis: implication in heart failure.
Circulation 2005;111(19):2469-76.
2004: Masashi Akaike; Wenyi Che; Nicole-Lerner Marmarosh; Shinsuke Ohta; Masaki Osawa; Bo Ding; Bradford C Berk; Chen Yan; Jun-ichi Abe
The hinge-helix 1 region of peroxisome proliferator-activated receptor gamma1 (PPARgamma1) mediates interaction with extracellular signal-regulated kinase 5 and PPARgamma1 transcriptional activation: involvement in flow-induced PPARgamma activation in endothelial cells.
Molecular and cellular biology 2004;24(19):8691-704.
2004: Masaki Osawa; Seigo Itoh; Shinsuke Ohta; Qunhua Huang; Bradford C Berk; Nicole-Lerner Marmarosh; Wenyi Che; Bo Ding; Chen Yan; Jun-ichi Abe
ERK1/2 associates with the c-Met-binding domain of growth factor receptor-bound protein 2 (Grb2)-associated binder-1 (Gab1): role in ERK1/2 and early growth response factor-1 (Egr-1) nuclear accumulation.
The Journal of biological chemistry 2004;279(28):29691-9.
2004: Scott J Cameron; Seigo Itoh; Christopher P Baines; Changxi Zhang; Shinsuke Ohta; Wenyi Che; Michael Glassman; Jiing-Dwan Lee; Chen Yan; Jay Yang; Jun-ichi Abe
Activation of big MAP kinase 1 (BMK1/ERK5) inhibits cardiac injury after myocardial ischemia and reperfusion.
FEBS letters 2004;566(1-3):255-60.
2004: Scott J Cameron; Jun-ichi Abe; Sundeep Malik; Wenyi Che; Jay Yang
Differential role of MEK5alpha and MEK5beta in BMK1/ERK5 activation.
The Journal of biological chemistry 2004;279(2):1506-12.
2003: nicole lerner-marmarosh; Masanori Yoshizumi; Wenyi Che; James Surapisitchat; Hisaaki Kawakatsu; Masashi Akaike; Bo Ding; Qunhua Huang; Chen Yan; Bradford C Berk; Jun-ichi Abe
Inhibition of tumor necrosis factor-[alpha]-induced SHP-2 phosphatase activity by shear stress: a mechanism to reduce endothelial inflammation.
Arteriosclerosis, thrombosis, and vascular biology 2003;23(10):1775-81.
2003: Toru Aizawa; Heng Wei; Joseph M Miano; Jun-ichi Abe; Bradford C Berk; Chen Yan
Role of phosphodiesterase 3 in NO/cGMP-mediated antiinflammatory effects in vascular smooth muscle cells.
Circulation research 2003;93(5):406-13.
2003: Scott J Cameron; Sundeep Malik; Masashi Akaike; nicole lerner-marmarosh; Chen Yan; Jiing-Dwan Lee; Jun-ichi Abe; Jay Yang
Regulation of epidermal growth factor-induced connexin 43 gap junction communication by big mitogen-activated protein kinase1/ERK5 but not ERK1/2 kinase activation.
The Journal of biological chemistry 2003;278(20):18682-8.
2002: Lung-Kuo Tai; Masanori Okuda; Jun-ichi Abe; Chen Yan; Bradford C Berk
Fluid shear stress activates proline-rich tyrosine kinase via reactive oxygen species-dependent pathway.
Arteriosclerosis, thrombosis, and vascular biology 2002;22(11):1790-6.
2002: Qunhua Huang; nicole lerner-marmarosh; Wenyi Che; Shinsuke Ohta; Masaki Osawa; Masanori Yoshizumi; Michael Glassman; Chen Yan; Bradford C Berk; Jun-ichi Abe
The novel role of the C-terminal region of SHP-2. Involvement of Gab1 and SHP-2 phosphatase activity in Elk-1 activation.
The Journal of biological chemistry 2002;277(32):29330-41.
2002: Yuji Saito; Yukihiro Hojo; Tatsuo Tanimoto; Jun-ichi Abe; Bradford C Berk
Protein kinase C-alpha and protein kinase C-epsilon are required for Grb2-associated binder-1 tyrosine phosphorylation in response to platelet-derived growth factor.
The Journal of biological chemistry 2002;277(26):23216-22.
2002: Wenyi Che; nicole lerner-marmarosh; Qunhua Huang; Masaki Osawa; Shinsuke Ohta; Masanori Yoshizumi; Michael Glassman; Jiing-Dwan Lee; Chen Yan; Bradford C Berk; Jun-ichi Abe
Insulin-like growth factor-1 enhances inflammatory responses in endothelial cells: role of Gab1 and MEKK3 in TNF-alpha-induced c-Jun and NF-kappaB activation and adhesion molecule expression.
Circulation research 2002;90(11):1222-30.
2002: Yasuchika Takeishi; Qunhua Huang; Jun-ichi Abe; Wenyi Che; Jiing-Dwan Lee; Hisaaki Kawakatsu; Brian D Hoit; Bradford C Berk; Richard A Walsh
Activation of mitogen-activated protein kinases and p90 ribosomal S6 kinase in failing human hearts with dilated cardiomyopathy.
Cardiovascular research 2002;53(1):131-7.
2001: Bradford C Berk; Jun-ichi Abe; W Min; James Surapisitchat; Chen Yan
Endothelial atheroprotective and anti-inflammatory mechanisms.
Annals of the New York Academy of Sciences 2001;947():93-109; discussion 109-11.
2001: Jun-ichi Abe; Wenyi Che; Masanori Yoshizumi; Qunhua Huang; Michael Glassman; Shinsuke Ohta; Y Wu; R Arlinghaus; Bradford C Berk
Bcr in vascular smooth muscle cells involvement of Ras and Raf-1 activation by Bcr.
Annals of the New York Academy of Sciences 2001;947():341-3.
2001: Yasuchika Takeishi; Qunhua Huang; T Wang; Michael Glassman; M Yoshizumi; Christopher P Baines; Jiing-Dwan Lee; Hisaaki Kawakatsu; Wenyi Che; nicole lerner-marmarosh; Changxi Zhang; Chen Yan; Shinsuke Ohta; Richard A Walsh; Bradford C Berk; Jun-ichi Abe
Src family kinase and adenosine differentially regulate multiple MAP kinases in ischemic myocardium: modulation of MAP kinases activation by ischemic preconditioning.
Journal of molecular and cellular cardiology 2001;33(11):1989-2005.
2001: Wenyi Che; Jun-ichi Abe; Masanori Yoshizumi; Qunhua Huang; Michael Glassman; Shinsuke Ohta; Matthew G Melaragno; Veronica Poppa; Chen Yan; nicole lerner-marmarosh; Changxi Zhang; Y Wu; R Arlinghaus; Bradford C Berk
p160 Bcr mediates platelet-derived growth factor activation of extracellular signal-regulated kinase in vascular smooth muscle cells.
Circulation 2001;104(12):1399-406.
2001: Yasuchika Takeishi; Qunhua Huang; Jun-ichi Abe; Michael Glassman; Wenyi Che; Jiing-Dwan Lee; Hisaaki Kawakatsu; E G Lawrence; Brian D Hoit; Bradford C Berk; Richard A Walsh
Src and multiple MAP kinase activation in cardiac hypertrophy and congestive heart failure under chronic pressure-overload: comparison with acute mechanical stretch.
Journal of molecular and cellular cardiology 2001;33(9):1637-48.
2001: Chen Yan; H Luo; Jiing-Dwan Lee; Jun-ichi Abe; Bradford C Berk
Molecular cloning of mouse ERK5/BMK1 splice variants and characterization of ERK5 functional domains.
The Journal of biological chemistry 2001;276(14):10870-8.
2000: Masanori Yoshizumi; Jun-ichi Abe; Judith Haendeler; Qunhua Huang; Bradford C Berk
Src and Cas mediate JNK activation but not ERK1/2 and p38 kinases by reactive oxygen species.
The Journal of biological chemistry 2000;275(16):11706-12.
2000: Jun-ichi Abe; M Okuda; Qunhua Huang; Masanori Yoshizumi; Bradford C Berk
Reactive oxygen species activate p90 ribosomal S6 kinase via Fyn and Ras.
The Journal of biological chemistry 2000;275(3):1739-48.
1999: Yasuchika Takeishi; Jun-ichi Abe; Jiing-Dwan Lee; Hisaaki Kawakatsu; Richard A Walsh; Bradford C Berk
Differential regulation of p90 ribosomal S6 kinase and big mitogen-activated protein kinase 1 by ischemia/reperfusion and oxidative stress in perfused guinea pig hearts.
Circulation research 1999;85(12):1164-72.
1999: Jun-ichi Abe; Bradford C Berk
Fyn and JAK2 mediate Ras activation by reactive oxygen species.
The Journal of biological chemistry 1999;274(30):21003-10.