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Reidar Albrechtsen

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Camilla Fröhlich; Marie Klitgaard; Alexander Kotzsch; Pauliina Kronqvist; Marie Kveiborg; Camilla Nehammer; Julie B Noer; Reidar Albrechtsen; Jens Berthelsen; Carl Blobel; Ulla M Wewer
ADAM12 is expressed in the tumour vasculature and mediates ectodomain shedding of several membrane-anchored endothelial proteins.
Dorte Stautz; Bo van Deurs; Ulla M Wewer; Reidar Albrechtsen; Michael V Grandal; Anthony Leyme; Marie Kveiborg
Cell-surface metalloprotease ADAM12 is internalized by a clathrin- and Grb2-dependent mechanism.
Camilla Fröhlich; Pauliina Kronqvist; Marie Kveiborg; Arthur M Mercurio; Camilla Nehammer; Atsuko Sehara-Fujisawa; Reidar Albrechtsen; Ulla M Wewer
ADAM12 produced by tumor cells rather than stromal cells accelerates breast tumor progression.

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All Publications

2013: Camilla Fröhlich; Marie Klitgaard; Alexander Kotzsch; Pauliina Kronqvist; Marie Kveiborg; Camilla Nehammer; Julie B Noer; Reidar Albrechtsen; Jens Berthelsen; Carl Blobel; Ulla M Wewer
ADAM12 is expressed in the tumour vasculature and mediates ectodomain shedding of several membrane-anchored endothelial proteins.
The Biochemical journal 2013;452(1):97-109.
2012: Dorte Stautz; Bo van Deurs; Ulla M Wewer; Reidar Albrechtsen; Michael V Grandal; Anthony Leyme; Marie Kveiborg
Cell-surface metalloprotease ADAM12 is internalized by a clathrin- and Grb2-dependent mechanism.
Traffic (Copenhagen, Denmark) 2012;13(11):1532-46.
2011: Camilla Fröhlich; Pauliina Kronqvist; Marie Kveiborg; Arthur M Mercurio; Camilla Nehammer; Atsuko Sehara-Fujisawa; Reidar Albrechtsen; Ulla M Wewer
ADAM12 produced by tumor cells rather than stromal cells accelerates breast tumor progression.
Molecular cancer research : MCR 2011;9(11):1449-61.
2011: Reidar Albrechtsen; Dorte Stautz; Archana Sanjay; Marie Kveiborg; Ulla M Wewer
Extracellular engagement of ADAM12 induces clusters of invadopodia with localized ectodomain shedding activity.
Experimental cell research 2011;317(2):195-209.
2010: Dorte Stautz; Archana Sanjay; Matilde Thye Hansen; Reidar Albrechtsen; Ulla M Wewer; Marie Kveiborg
ADAM12 localizes with c-Src to actin-rich structures at the cell periphery and regulates Src kinase activity.
Experimental cell research 2010;316(1):55-67.
2008: Hans Peter Sørensen; Romain R Vivès; Christina Manetopoulos; Reidar Albrechtsen; Magnus C Lydolph; Jonas Jacobsen; John R Couchman; Ulla M Wewer
Heparan sulfate regulates ADAM12 through a molecular switch mechanism.
The Journal of biological chemistry 2008;283(46):31920-32.
2008: Marie Kveiborg; Reidar Albrechtsen; John R Couchman; Ulla M Wewer
Cellular roles of ADAM12 in health and disease.
The international journal of biochemistry & cell biology 2008;40(9):1685-702.
2006: Camilla Fröhlich; Reidar Albrechtsen; Lars Dyrskjøt; Lise Rudkjaer; Torben F Ørntoft; Ulla M Wewer
Molecular profiling of ADAM12 in human bladder cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 2006;12(24):7359-68.
2006: Marie Kveiborg; Reidar Albrechtsen; Lise Rudkjaer; Guanmei Wen; Karen Damgaard-Pedersen; Ulla M Wewer
ADAM12-S stimulates bone growth in transgenic mice by modulating chondrocyte proliferation and maturation.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2006;21(8):1288-96.
2006: Ulla M Wewer; Matthias Mörgelin; Peter Holck; Jonas Jacobsen; Magnus C Lydolph; Anders H Johnsen; Marie Kveiborg; Reidar Albrechtsen
ADAM12 is a four-leafed clover: the excised prodomain remains bound to the mature enzyme.
The Journal of biological chemistry 2006;281(14):9418-22.
2005: Charles Kumar Thodeti; Camilla Fröhlich; Christian Kamp Nielsen; Yoshikazu Takada; Reinhard Fässler; Reidar Albrechtsen; Ulla M Wewer
ADAM12-mediated focal adhesion formation is differently regulated by beta1 and beta3 integrins.
FEBS letters 2005;579(25):5589-95.
2005: Charles Kumar Thodeti; Camilla Fröhlich; Christian Kamp Nielsen; Peter Holck; Christina Sundberg; Marie Kveiborg; Yashithra Mahalingam; Reidar Albrechtsen; John R Couchman; Ulla M Wewer
Hierarchy of ADAM12 binding to integrins in tumor cells.
Experimental cell research 2005;309(2):438-50.
2005: Marie Kveiborg; Camilla Fröhlich; Reidar Albrechtsen; Verena Tischler; Nikolaj Dietrich; Peter Holck; Pauliina Kronqvist; Fritz Rank; Arthur M Mercurio; Ulla M Wewer
A role for ADAM12 in breast tumor progression and stromal cell apoptosis.
Cancer research 2005;65(11):4754-61.
2004: Christina Sundberg; Charles Kumar Thodeti; Marie Kveiborg; Christer Larsson; Peter Parker; Reidar Albrechtsen; Ulla M Wewer
Regulation of ADAM12 cell-surface expression by protein kinase C epsilon.
The Journal of biological chemistry 2004;279(49):51601-11.
2003: Jennie Laigaard; Tina Sørensen; Camilla Fröhlich; Bent Nørgaard Pedersen; Michael Christiansen; Kirsten Schiøtt; Niels Uldbjerg; Reidar Albrechtsen; Helle V Clausen; Bent Ottesen; Ulla M Wewer
ADAM12: a novel first-trimester maternal serum marker for Down syndrome.
Prenatal diagnosis 2003;23(13):1086-91.
2003: Nobuko Kawaguchi; Christina Sundberg; Marie Kveiborg; Behzad Moghadaszadeh; Meena Asmar; Nikolaj Dietrich; Charles Kumar Thodeti; Omid Niazi; Peter Möller; Arthur M Mercurio; Reidar Albrechtsen; Ulla M Wewer
ADAM12 induces actin cytoskeleton and extracellular matrix reorganization during early adipocyte differentiation by regulating beta1 integrin function.
Journal of cell science 2003;116(Pt 19):3893-904.
2003: Behzad Moghadaszadeh; Reidar Albrechtsen; Ling T Guo; Michaela Zaik; Nobuko Kawaguchi; Rehannah Borup; Pauliina Kronqvist; Henrik D Schroder; Kay E Davies; Thomas Voit; Omid Niazi; Eva Engvall; Ulla M Wewer
Compensation for dystrophin-deficiency: ADAM12 overexpression in skeletal muscle results in increased alpha 7 integrin, utrophin and associated glycoproteins.
Human molecular genetics 2003;12(19):2467-79.
2003: Charles Kumar Thodeti; Reidar Albrechtsen; Morten Grauslund; Meena Asmar; Christer Larsson; Yoshikazu Takada; Arthur M Mercurio; John R Couchman; Ulla M Wewer
ADAM12/syndecan-4 signaling promotes beta 1 integrin-dependent cell spreading through protein kinase Calpha and RhoA.
The Journal of biological chemistry 2003;278(11):9576-84.
2002: Pauliina Kronqvist; Nobuko Kawaguchi; Reidar Albrechtsen; Xiufeng Xu; Henrik Daa Schrøder; Behzad Moghadaszadeh; Omid Niazi; Camilla Fröhlich; Eva Engvall; Ulla M Wewer
ADAM12 alleviates the skeletal muscle pathology in mdx dystrophic mice.
The American journal of pathology 2002;161(5):1535-40.
2002: Nobuko Kawaguchi; Xiufeng Xu; Rie Tajima; Pauliina Kronqvist; Christina Sundberg; Frosty Loechel; Reidar Albrechtsen; Ulla M Wewer
ADAM 12 protease induces adipogenesis in transgenic mice.
The American journal of pathology 2002;160(5):1895-903.
2001: K Iba; ME Durkin; Lise Lyck; E Hunziker; K Damgaard-Pedersen; H Zhang; Eva Engvall; Reidar Albrechtsen; Ulla M Wewer
Mice with a targeted deletion of the tetranectin gene exhibit a spinal deformity.
Molecular and cellular biology 2001;21(22):7817-25.
2001: ME Durkin; Omid Niazi; Frosty Loechel; Reidar Albrechtsen; Ulla M Wewer
Regulation of laminin beta2 chain gene expression in human cancer cell lines.
European journal of biochemistry / FEBS 2001;268(13):3797-806.
2001: X Xu; BJ Gilpin; K Iba; A Maier; Eva Engvall; Reidar Albrechtsen; Ulla M Wewer
Tetranectin in slow intra- and extrafusal chicken muscle fibers.
Journal of muscle research and cell motility 2001;22(2):121-32.
2000: Frosty Loechel; J W Fox; G Murphy; Reidar Albrechtsen; Ulla M Wewer
ADAM 12-S cleaves IGFBP-3 and IGFBP-5 and is inhibited by TIMP-3.
Biochemical and biophysical research communications 2000;278(3):511-5.
2000: S Hougaard; Frosty Loechel; Xiufeng Xu; R Tajima; Reidar Albrechtsen; Ulla M Wewer
Trafficking of human ADAM 12-L: retention in the trans-Golgi network.
Biochemical and biophysical research communications 2000;275(2):261-7.
2000: K Iba; Reidar Albrechtsen; BJ Gilpin; Camilla Fröhlich; Frosty Loechel; A Zolkiewska; K Ishiguro; T Kojima; Wei Liu; J Kevin Langford; Ralph D Sanderson; Cord Brakebusch; Reinhard Fässler; Ulla M Wewer
The cysteine-rich domain of human ADAM 12 supports cell adhesion through syndecans and triggers signaling events that lead to beta1 integrin-dependent cell spreading.
The Journal of cell biology 2000;149(5):1143-56.
1999: Frosty Loechel; M T Overgaard; Claus Oxvig; Reidar Albrechtsen; Ulla M Wewer
Regulation of human ADAM 12 protease by the prodomain. Evidence for a functional cysteine switch.
The Journal of biological chemistry 1999;274(19):13427-33.
1999: K Iba; Reidar Albrechtsen; BJ Gilpin; Frosty Loechel; Ulla M Wewer
Cysteine-rich domain of human ADAM 12 (meltrin alpha) supports tumor cell adhesion.
The American journal of pathology 1999;154(5):1489-501.
1999: M E Durkin; Anne Charlotte Jäger; T S Khurana; Omid Niazi; Reidar Albrechtsen; Ulla M Wewer
Characterization of the human laminin beta2 chain locus (LAMB2): linkage to a gene containing a nonprocessed, transcribed LAMB2-like pseudogene (LAMB2L) and to the gene encoding glutaminyl tRNA synthetase (QARS).
Cytogenetics and cell genetics 1999;84(3-4):173-8.
1998: M E Durkin; Reidar Albrechtsen; DM Chambers; CM Abbott; Ulla M Wewer
Evaluation of Lama5 as a candidate for the mouse ragged (Ra) mutation.
Biochemical and biophysical research communications 1998;250(1):125-30.
1998: Ulla M Wewer; K Iba; ME Durkin; Omid Niazi; Frosty Loechel; BJ Gilpin; W Kuang; Eva Engvall; Reidar Albrechtsen
Tetranectin is a novel marker for myogenesis during embryonic development, muscle regeneration, and muscle cell differentiation in vitro.
Developmental biology 1998;200(2):247-59.
1998: Frosty Loechel; BJ Gilpin; Eva Engvall; Reidar Albrechtsen; Ulla M Wewer
Human ADAM 12 (meltrin alpha) is an active metalloprotease.
The Journal of biological chemistry 1998;273(27):16993-7.
1998: BJ Gilpin; Frosty Loechel; M G Mattei; Eva Engvall; Reidar Albrechtsen; Ulla M Wewer
A novel, secreted form of human ADAM 12 (meltrin alpha) provokes myogenesis in vivo.
The Journal of biological chemistry 1998;273(1):157-66.
1997: Ulla M Wewer; Leslie M Shaw; Reidar Albrechtsen; Arthur M Mercurio
The integrin alpha 6 beta 1 promotes the survival of metastatic human breast carcinoma cells in mice.
The American journal of pathology 1997;151(5):1191-8.
1997: Ulla M Wewer; Lars-Eric Thornell; Frosty Loechel; X Zhang; ME Durkin; S Amano; R E Burgeson; Eva Engvall; Reidar Albrechtsen; I Virtanen
Extrasynaptic location of laminin beta 2 chain in developing and adult human skeletal muscle.
The American journal of pathology 1997;151(2):621-31.
1997: ME Durkin; Frosty Loechel; M G Mattei; BJ Gilpin; Reidar Albrechtsen; Ulla M Wewer
Tissue-specific expression of the human laminin alpha5-chain, and mapping of the gene to human chromosome 20q13.2-13.3 and to distal mouse chromosome 2 near the locus for the ragged (Ra) mutation.
FEBS letters 1997;411(2-3):296-300.
1997: M E Durkin; Susan Naylor; Reidar Albrechtsen; Ulla M Wewer
Assignment of the gene for human tetranectin (TNA) to chromosome 3p22-->p21.3 by somatic cell hybrid mapping.
Cytogenetics and cell genetics 1997;76(1-2):39-40.
1996: ME Durkin; M Gautam; Frosty Loechel; Joshua R Sanes; J P Merlie; Reidar Albrechtsen; Ulla M Wewer
Structural organization of the human and mouse laminin beta2 chain genes, and alternative splicing at the 5' end of the human transcript.
The Journal of biological chemistry 1996;271(23):13407-16.
1995: Ulla M Wewer; ME Durkin; X Zhang; H Laursen; N H Nielsen; J Towfighi; Eva Engvall; Reidar Albrechtsen
Laminin beta 2 chain and adhalin deficiency in the skeletal muscle of Walker-Warburg syndrome (cerebro-ocular dysplasia-muscular dystrophy).
Neurology 1995;45(11):2099-101.
1995: K Ibaraki; Christine A Kozak; U M Wewer; Reidar Albrechtsen; Marian F Young
Mouse tetranectin: cDNA sequence, tissue-specific expression, and chromosomal mapping.
Mammalian genome : official journal of the International Mammalian Genome Society 1995;6(10):693-6.
1994: Ulla M Wewer; K Ibaraki; P Schjørring; ME Durkin; Marian F Young; Reidar Albrechtsen
A potential role for tetranectin in mineralization during osteogenesis.
The Journal of cell biology 1994;127(6 Pt 1):1767-75.
1994: Ulla M Wewer; D R Gerecke; ME Durkin; K S Kurtz; M G Mattei; Marie-France Champliaud; Robert E Burgeson; Reidar Albrechtsen
Human beta 2 chain of laminin (formerly S chain): cDNA cloning, chromosomal localization, and expression in carcinomas.
Genomics 1994;24(2):243-52.
1994: U M Wewer; E A Wayner; B G Hoffstrom; F Lan; B Meyer-Nielsen; Eva Engvall; Reidar Albrechtsen
Selective assembly of laminin variants by human carcinoma cells.
Laboratory investigation; a journal of technical methods and pathology 1994;71(5):719-30.
1992: U M Wewer; Reidar Albrechtsen
Tetranectin, a plasminogen kringle 4-binding protein. Cloning and gene expression pattern in human colon cancer.
Laboratory investigation; a journal of technical methods and pathology 1992;67(2):253-62.
1992: U M Wewer; E Engvall; M Paulsson; Y Yamada; Reidar Albrechtsen
Laminin A, B1, B2, S and M subunits in the postnatal rat liver development and after partial hepatectomy.
Laboratory investigation; a journal of technical methods and pathology 1992;66(3):378-89.
1992: U M Wewer; Reidar Albrechtsen
Carcinoma-associated perisinusoidal laminin may signal tumour cell metastasis to the liver.
Virchows Archiv. A, Pathological anatomy and histopathology 1992;421(2):87-93.
1990: U M Wewer; A M Mercurio; S Y Chung; Reidar Albrechtsen
Deoxyribonucleic-binding homeobox proteins are augmented in human cancer.
Laboratory investigation; a journal of technical methods and pathology 1990;63(4):447-54.
1988: U M Wewer; Reidar Albrechtsen; Larry W Fisher; Marian F Young; J D Termine
Osteonectin/SPARC/BM-40 in human decidua and carcinoma, tissues characterized by de novo formation of basement membrane.
The American journal of pathology 1988;132(2):345-55.
1988: S Holck; U M Wewer; Reidar Albrechtsen
Heterogeneity of secretory granules of silent pituitary adenomas.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 1988;1(3):212-5.
1988: Reidar Albrechtsen; U M Wewer; Snorri S Thorgeirsson
De novo deposition of laminin-positive basement membrane in vitro by normal hepatocytes and during hepatocarcinogenesis.
Hepatology (Baltimore, Md.) 1988;8(3):538-46.
1987: U M Wewer; G Taraboletti; M E Sobel; Reidar Albrechtsen; Lance A Liotta
Role of laminin receptor in tumor cell migration.
Cancer research 1987;47(21):5691-8.
1987: S Holck; Reidar Albrechtsen; U M Wewer
Laminin in the anterior pituitary gland of the rat. Laminin in the gonadotrophic cells correlates with their functional state.
Laboratory investigation; a journal of technical methods and pathology 1987;56(5):481-8.
1987: S Holck; U M Wewer; Reidar Albrechtsen
Light bodies in human pituitary adenomas.
Virchows Archiv. A, Pathological anatomy and histopathology 1987;411(4):311-4.
1986: U M Wewer; Lance A Liotta; Michael Jaye; G A Ricca; W N Drohan; A P Claysmith; C N Rao; P Wirth; J E Coligan; Reidar Albrechtsen
Altered levels of laminin receptor mRNA in various human carcinoma cells that have different abilities to bind laminin.
Proceedings of the National Academy of Sciences of the United States of America 1986;83(19):7137-41.
1986: M Faber; U M Wewer; J G Berthelsen; L A Liotta; Reidar Albrechtsen
Laminin production by human endometrial stromal cells relates to the cyclic and pathologic state of the endometrium.
The American journal of pathology 1986;124(3):384-91.
1986: Reidar Albrechtsen; U M Wewer; L A Liotta
Basement membranes in human cancer.
Pathology annual 1986;21 Pt 2():251-76.
1986: S Holck; U M Wewer; Reidar Albrechtsen
Intercellular deposits of basement membrane material in active human pituitary adenomas detected by immunostaining for laminin and electron microscopy.
Acta neuropathologica 1986;71(3-4):326-31.
1985: U M Wewer; M Faber; L A Liotta; Reidar Albrechtsen
Immunochemical and ultrastructural assessment of the nature of the pericellular basement membrane of human decidual cells.
Laboratory investigation; a journal of technical methods and pathology 1985;53(6):624-33.
1985: U M Wewer; Reidar Albrechtsen
[Laminin, a component of the basement membrane].
Ugeskrift for laeger 1985;147(27):2146-9.
1985: U M Wewer; Reidar Albrechtsen; J R Hassell
Heparan sulfate proteoglycans made by different basement-membrane-producing tumors have immunological and structural similarities.
Differentiation; research in biological diversity 1985;30(1):61-7.